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Starry Sky on MRI Brain: Unusually Observed in a Pediatric Case of Japanese Encephalitis MRI脑上的星空:一例日本脑炎患儿的异常观察
Pub Date : 2022-11-13 DOI: 10.18502/crcp.v7i3.11128
Durgesh Kumar, D. Kumar, Rajesh Kumar Yadav
A 13-year-old girl presented with fever, nausea and projectile vomiting and altered sensorium. On physical examination, the meningeal signs were presented without focal neurological deficits and Grade Ⅱ papilledema was presented on fundus examination. The patient was found to be positive for Japanese encephalitis virus in cerebrospinal fluid. Focal neurological deficit in the form of right hemiparesis was noticed at day 6 of hospitalisation. Multiple lesions with minimal enhancement with perilesional edema were observed in cerebral cortex in contrast with enhanced magnetic resonance imaging of the brain, givingrise to starry sky appearance. No tests for neurotuberculosis were found positive. Serum IgG enzyme-linked immunosorbent assay test was negative for Cysticercosis, but magnetic resonance spectroscopy was suggestive of cysticercal meningitis. During treatment, she had intermittent episodes of nausea and vomiting with waxing and waning sensorium. Subsequently, it was planned to start Albendazole after steroids coverage and anticonvulsants but the patient did not improve and succumbed to her illness.
一名13岁女孩出现发烧、恶心、抛射性呕吐和感觉功能改变。体格检查显示脑膜体征无局灶性神经功能缺损,眼底检查显示Ⅱ级视乳头水肿。病人的脑脊液中发现日本脑炎病毒呈阳性。在住院的第6天注意到以右偏瘫形式出现的局灶性神经功能缺损。在大脑皮层观察到多处病变,病变周围水肿,与增强的大脑磁共振成像形成对比,导致星空出现。没有发现神经营养不良的测试呈阳性。血清IgG酶联免疫吸附试验对囊尾蚴病呈阴性,但磁共振波谱提示为囊尾蚴脑膜炎。在治疗过程中,她出现了间歇性恶心和呕吐,并伴有感觉功能的增强和减弱。随后,计划在服用类固醇和抗惊厥药物后开始服用阿苯达唑,但患者没有好转,最终死于疾病。
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引用次数: 1
Endoscopic Endonasal Approach to Cavernous Sinus Hemangioma: A Report of Two Cases and Review of the Literature 内窥镜入路治疗海绵窦血管瘤2例报告并文献复习
Pub Date : 2022-11-13 DOI: 10.18502/crcp.v7i3.11121
A. Fathi, M. Rashidbeygi, Maryamalsadat Mousavi, Zahra Azizan, S. Sadrehosseini, Azin Tabari, Mehdi Zeinalizadeh
Cavernous sinus hemangiomas (CSHs) are rare, benign, slow-growing neoplasms within the cavernous sinus. Laterally located to these lesions, the cranial nerves and carotid artery are subject to injury during removal of hemangiomas through a transcranial route. Therefore, forsurgi- cal management of cavernous sinus hemangiomas a medial corridor granted through an endoscop- ic endonasal approach may be less traumatic to the neurovascular bundle. Case-1 describes a 23-year old male who presented with intermittent blurred vision and very mild ptosis on the right side for two yearsbefore admission. Fundoscopic exam, visual acuity and perimetry tests were normal. With intense enhancement after contrastadministration, both brain MRI and CT scan demonstrated an extra-axial mass in the right cavernous sinus. Case-2 presents a 59-year-old male, a known case of renal oncocytoma who underwent nephrec- tomy a year before, with chief complain ofmoderate intermittent headaches. Imaging study of the brain by MRI revealed a sellar mass. Near-total resection for case-1 and gross total resection for case-2 were performed through the an extended endoscopic endonasal approach. We report two cases of near-total and gross total resection of CSHs via an extend- ed endoscopic endonasal approach substantiatingadvances in minimal access neurosurgery to the treatment of such grim lesions of an intricate vicinity of the skull base. At the same time, we focus to review extensively the growing yet heterogenous literature of the past twenty years on the broached topic. The evolution of extended endoscopic endonasal approach over the past two decades changes the dynamism of the surgical practices steeped in tradition and provides a safer alternate route for preserving cranial nerves of this anatomic region.
海绵窦血管瘤(CSHs)是一种罕见的、良性的、生长缓慢的海绵窦肿瘤。颅神经和颈动脉位于这些病变的外侧,在经颅切除血管瘤的过程中容易受到损伤。因此,对于海绵窦血管瘤的手术治疗,经内窥镜鼻内入路给予内侧通道可能对神经血管束的创伤较小。病例1描述了一名23岁男性,入院前两年出现间歇性视力模糊和右侧非常轻微的上睑下垂。眼底检查、视力及周边检查均正常。脑MRI和CT扫描均显示右侧海绵窦轴外肿块。病例2为一名59岁男性,一年前行肾切除术,已知患有肾嗜瘤细胞瘤,主诉为中度间歇性头痛。脑部核磁共振成像显示有鞍状肿块。病例1的近全切除和病例2的全切除均通过扩大内镜鼻内入路进行。我们报告两例经扩大内窥镜鼻内入路近全和全切除CSHs的病例,证实了微创神经外科治疗颅底复杂附近这种严重病变的进展。与此同时,我们将重点广泛回顾过去二十年来关于这一主题的日益增长但异质性的文献。在过去的二十年中,扩展内窥镜鼻内入路的发展改变了传统手术实践的活力,并为保存该解剖区域的脑神经提供了更安全的替代途径。
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引用次数: 0
Prenatal Diagnosis of Congenitally Corrected Transposition of the Great Arteries (CCTGA): A Case Report 先天性大动脉转位(CCTGA)的产前诊断:1例报告
Pub Date : 2022-11-13 DOI: 10.18502/crcp.v7i3.11119
Nasir Hematian, S. Torabi, S. Hantoushzadeh, Maasoumeh Saleh, Mahboubeh Saleh
CCTGA, also known as levo- or L-loop transposition (L-TGA), double discordance, or ventricular inversion, is a rare cardiovascular anomaly with inversion of the ventricles and great arteries. In this anomaly, the right atrium communicates with the morpho- logic left ventricle, which gives rise to the pulmonary artery, while the left atrium communicates with the morphologic right ventricle, which gives rise to the aorta. Thus, atrioventricular and ventriculoarterial discordance (double discordance) exist, and although the blood flows in the normal direction, it passes through the wrong ventricular chambers. It is a unique conotruncal anomaly, inwhich the four-chamber view is abnormal. It may be associated with other heart disorders. In most fetuses, TGA remains undiagnosed before birth. The diagnosis of TGA can be made by care- fully and appropriately evaluating the anatomic locationsof cardiac chambers and the connections between the atria, ventricles, and great arteries with high-resolution ultrasound. Patients with isolated CTGA generally present later in life with signs and symptoms related to either arrhythmias or heart failure. TGA is rarely associated with chromosomal abnormality and amniocentesis is usually not undertaken. We report a case of CTGA detected at 18 week’s gestation on screening ultrasound.
CCTGA,也被称为左旋或左旋环转位(L-TGA),双不一致或心室倒置,是一种罕见的心血管异常,伴有心室和大动脉倒置。在这种异常中,右心房与形态上的左心室相通,后者产生肺动脉,而左心房与形态上的右心室相通,后者产生主动脉。因此,存在房室和室动脉不协调(双重不协调),尽管血液在正常方向流动,但它通过错误的心室。这是一个独特的圆锥锥体异常,其中四腔视图是异常的。它可能与其他心脏疾病有关。在大多数胎儿中,TGA在出生前仍未被诊断出来。TGA的诊断可以通过高分辨率超声仔细、适当地评估心腔的解剖位置以及心房、心室和大动脉之间的连接来进行。孤立性CTGA患者通常在生命后期出现与心律失常或心力衰竭相关的体征和症状。TGA很少与染色体异常相关,通常不进行羊膜穿刺术。我们报告一例CTGA发现在18周妊娠超声筛查。
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引用次数: 0
Sarcoidosis in Close Family Members and Susceptibility to High Grade B-Cell Lymphoma: A Case Report Study 近亲属结节病与高级别b细胞淋巴瘤易感性:一个病例报告研究
Pub Date : 2022-11-13 DOI: 10.18502/crcp.v7i3.11120
Hana Magrooni, N. Javadian, Ghasem Farahmand, Sakineh Ranji-Burachaloo
The presented case is an 81- year-old woman who had experienced episodes of facial twitching without loss of consciousness and flu like symptoms for a few weeks prior to her admission. examinations were unremarkable except for left 3rd nerve and right 6th nerve palsy, right peripheral facial palsy and right -side hemiparesis. FH was positive for sarcoidosis. neuroimaging were in favor of PCNSL. Sarcoidosis and malignancy maybe etiologically related in at least 25% of cases. Coexis- tence of sarcoidosis and lymphoma have been reported previously. Our patient had two daughters with sarcoidosis and her chest CT scan showed multiple lymph nodes inmedias- tinum. Unfortunately, due to the location and the technical restriction, biopsy of mediasti- nal lymph nodes was not performedfor our patient and we could not differentiate whether it was reactive, paraneoplastic or granulomatous. We present this case as concurrence of lymphoma and sarcoidosis in a family, which could guide a new concern for the patient with granulomatous infiltrative disease for early diagnosis and familial screening.
该病例是一名81岁的女性,在入院前的几周内,她经历了面部抽搐,没有失去意识和流感样症状。除左侧第3神经和右侧第6神经麻痹、右侧周围性面瘫和右侧偏瘫外,其余检查均无异常。FH结节病阳性。神经影像学检查有利于PCNSL。结节病和恶性肿瘤可能在至少25%的病例中与病因有关。结节病和淋巴瘤的并发症已有报道。我们的病人有两个女儿患有结节病,她的胸部CT扫描显示中间有多个淋巴结。不幸的是,由于位置和技术限制,我们的患者没有进行中间淋巴结活检,我们无法区分它是反应性的、副肿瘤性的还是肉芽肿性的。我们将该病例描述为淋巴瘤和结节病在一个家族中同时发生,这可能为肉芽肿性浸润性疾病患者的早期诊断和家族筛查提供新的关注点。
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引用次数: 0
Appendicovesical Fistula, as the First Presentation of Mucinous Adenocarcinoma of Appendix: A Case Report 阑尾粘液腺癌首次表现为阑尾膀胱瘘1例报告
Pub Date : 2022-11-13 DOI: 10.18502/crcp.v7i3.11118
Narjes Mohammadzadeh, S. Hashemi
In this case report, a man presenting with a rare symptom of appendix cancer is dis- cussed. Hematuria, which was the key diagnostic feature in this patient, has never been re- ported as a presenting feature of appendix cancer which may explain why this patient has been experiencing this symptom for months and yet have not get the proper di- agnosis. As we discussed in the case report, although appendiceal cancer is a potentially life-threatening issue, it is frequently missed in patients. Therefore, we believe report- ing this key symptom in this journal would help physicians to make a more accurate diagnosis in this matter.
在这个病例报告中,我们讨论了一个罕见的阑尾癌症状。血尿是该患者的主要诊断特征,但从未被报道为阑尾癌的表现特征,这可能解释了为什么该患者经历了数月的症状但仍未得到适当的诊断。正如我们在病例报告中所讨论的,虽然阑尾癌是一个潜在的危及生命的问题,但它经常被患者忽视。因此,我们相信在杂志上报道这一关键症状将有助于医生对这一问题做出更准确的诊断。
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引用次数: 0
Hereditary Hemochromatosis and Alpha-Thalassemia Presenting with Diabetes Mellitus: A Rare Case Report 糖尿病并发遗传性血色素沉着症和α地中海贫血:一例罕见病例报告
Pub Date : 2022-11-13 DOI: 10.18502/crcp.v7i3.11125
Pourya Farhangi, M. Hajmiri, N. Shirzad, M. Hemmatabadi
Hereditary hemochromatosis (HH) is a rare genetic disorder, causing systemic iron overload. High amounts of iron in the bloodstream gradually oversaturate the trans- ferrin which can cause sedimentation of iron in the pancreas, liver, heart, pituitaryand joints, though it can establish multiorgan involvements. We present a case of TFR2 (type 3) HH who had minor α-thalassemia and uncontrolled diabetes mellitus, and discuss the clinical presentation and patient management. A 33-year-old man with type 3 HH and alpha-thalassemia trait, presented with uncon- trolled diabetes mellitus, skin hyperpigmentation and hypogonadism. The patient had high blood glucose ,despite the administration of 80 units of Glargineand 80 units of Aspart insulins per day, but after changing them into human insulins, his diabetes mellitus was surprisingly controlled with only 32 units of NPH and 18 units of Regular insulins. Furthermore, he was treated with testosterone (due to hypogonadism) and Deferasirox (due to iron overload).
遗传性血色素沉着症(HH)是一种罕见的遗传性疾病,可引起全身铁过载。血液中大量的铁会使反式铁蛋白逐渐过饱和,这会导致胰腺、肝脏、心脏、垂体和关节中的铁沉积,尽管它会导致多器官受累。我们报告了一例TFR2(3型)HH,其患有轻微的α-地中海贫血和未控制的糖尿病,并讨论了其临床表现和患者管理。一名33岁男性,具有3型HH和α地中海贫血特征,表现为糖尿病、皮肤色素沉着和性腺功能减退。尽管患者每天服用80单位甘精氨酸和80单位天冬氨酸胰岛素,但血糖仍很高,但在将其改为人胰岛素后,他的糖尿病仅用32单位NPH和18单位常规胰岛素得到了令人惊讶的控制。此外,他还接受了睾酮(由于性腺功能减退)和去甲罗克斯(由于铁过载)的治疗。
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引用次数: 1
Pancreatic Tuberculosis Mimicking a Mass: A Case Report 模拟肿块的胰腺结核一例报告
Pub Date : 2022-11-13 DOI: 10.18502/crcp.v7i3.11127
S. Deme, Bhaskar Kakarla, R. Thakur, Purushotham Ramireddygari, Nageswara Rao Modugu
Tuberculosis, a preventable and curable disease caused by Mycobacterium tuberculosis, is the leading infectious cause of mortality worldwide. Organs commonly affected are lungs and extrapulmonary organs like lymph nodes, meninges, bones, genitourinary and gastrointestinal tract. Ileocaecal tuberculosis is the commonest form of the gastrointestinal tract. Disseminated infection can involve almost all organs in the body but isolated pancreatic tuberculosis is rarely reported in the literature. Hereby,we report a case of a young female presenting with abdominal pain and further evaluation with imaging revealed pancreatic mass raising suspicion of malignancy. Endoscopic ultrasound (EUS) guided FNAC of pancreatic mass surprisingly revealed necrotizing granulomatous lesions favoring tuberculosis. This was further supported by the complete resolution of the mass with Antituberculous Therapy (ATT). What is important: All pancreatic masses are not malignant. Infectious causes like tuberculosis should be considered in the differential diagnosis which is curable by medication. With a high index of suspicion and adequate workup, unnecessary invasive procedures can be avoided.    
结核病是由结核分枝杆菌引起的一种可预防和可治愈的疾病,是全球死亡的主要传染原因。通常受影响的器官是肺和肺外器官,如淋巴结、脑膜、骨骼、泌尿生殖道和胃肠道。盲肠结核是最常见的胃肠道疾病。播散性感染几乎可以涉及身体的所有器官,但文献中很少报道孤立的胰腺结核。在此,我们报告了一例年轻女性出现腹痛的病例,进一步的影像学评估显示胰腺肿块引起了恶性肿瘤的怀疑。内镜超声(EUS)引导的胰腺肿块FNAC令人惊讶地显示有利于结核的坏死性肉芽肿性病变。这进一步得到了抗结核治疗(ATT)完全解决肿块的支持。重要的是:所有胰腺肿块都不是恶性的。在鉴别诊断中应考虑像肺结核这样的传染病病因,这是可以通过药物治愈的。有了高怀疑指数和充分的检查,就可以避免不必要的侵入性手术。
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引用次数: 0
Case Series of Pneumomediastinum and Subcutaneous Emphysema in COVID-19 Patients COVID-19患者纵隔气肿与皮下肺气肿病例系列分析
Pub Date : 2022-11-13 DOI: 10.18502/crcp.v7i3.11126
Y. Tan, Vivek Vijayan, K. K. Sia
Spontaneous pneumomediastinum has been reported in association with COVID-19. Pneumomediastinum could remainelusive until computed tomogra- phy is performed. Hence, we need to be vigilant even though it generally has a benign clinical course. We presented four confirmed COVID-19 cases with typical ground glass opacity on chest radiograph. All four had the computedtomography that re- vealed pneumomediastinum, pneumothorax and subcutaneous emphysema. Only one patient had pneumomediastinum after intubation. Pneumomediastinum is a devastating finding which should be picked up as early as possible and must be excluded in COVID patients whom deteriorate quickly, as adequate time may pass before any viable intervention can be done to expedite the patients’ recovery.
自发性纵隔肺炎已被报道与COVID-19相关。纵隔气肿在进行计算机断层扫描之前可能难以发现。因此,我们需要保持警惕,即使它通常有一个良性的临床过程。我们报告了4例确诊的COVID-19胸片上典型的磨玻璃影。4例患者均行计算机断层扫描,发现纵膈气肿、气胸和皮下肺气肿。只有1例患者插管后出现纵隔气肿。纵隔肺炎是一种毁灭性的发现,应尽早发现,并且在病情迅速恶化的COVID患者中必须排除,因为在采取任何可行的干预措施以加速患者康复之前可能需要足够的时间。
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引用次数: 0
Abdominal Wall Synovial Sarcoma, a Rare Presentation 罕见的腹壁滑膜肉瘤
Pub Date : 2022-11-13 DOI: 10.18502/crcp.v7i3.11117
E. Nazar, Zohre Shabanzade, Amir Ahmadi
Synovial sarcoma is a malignant mesenchymal neoplasm which com- monly arises in the extremities of adults, in close associationwith joint capsules. Only a few cases of synovial sarcoma occurring in the abdominal wall have been reported. We report an extremely rare case of monophasic synovial sarcoma of abdominal wall in a 58-year-old woman who had presented with painless left ante- rior abdominal wall mass. The patient underwent excisional surgery. Histological and immunohistochemistry examinations revealed monophasic synovial sarcoma. Base on the diagnosis, the patientreceived chemoradiation.Primary synovial sarcoma is rarely found in the anterior abdominal wall. But, it should be included in the differential diagnosis.
滑膜肉瘤是一种恶性间质肿瘤,常见于成人四肢,与关节囊密切相关。滑膜肉瘤发生在腹壁只有少数病例被报道。我们报告一例极其罕见的单纯性腹壁滑膜肉瘤病例,患者为58岁女性,表现为左侧腹壁前无痛性肿块。病人接受了切除手术。组织学及免疫组化检查显示为单相滑膜肉瘤。根据诊断,患者接受了放化疗。原发性滑膜肉瘤很少见于前腹壁。但是,它应该包括在鉴别诊断中。
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引用次数: 0
Massive Enlargement of The Tongue: A Report of Unusual Case 舌肿大:一罕见病例报告
Pub Date : 2022-10-11 DOI: 10.18502/crcp.v7i2.10823
R. Erfanian, F. Heidari, Saeed Sohrabpour, S. Shakiba
A 35- year- old woman presented with massive enlargement of the tongue. She had suffered this problem since a week ago when her tongue became enlarged with a sudden onset and eventually did not fit her mouth. Chronic tongue enlargement since childhood is noted. Patient had history of mental problems, namely cerebral palsy, and as she is not able to walk, she uses a wheelchair. Furthermore, due to severe scoliosis, right lung was atelectatic. Soon after initial assessments, she was carried to surgery room and as she could not lie down to supine position, was intubated in sitting position with a rigid laryngoscope. During the whole process, patient was sedated. Afterwards, tracheostomy was performed. After 5 days, no improvement in the size of tongue was observed. Diagnosis was revised in a medical commission and despite inflammatory pathology, the bulging tongue was resected. After recovery, patient could bear oral feeding and was dismissed with good general health. After a week, the devised airway created by tracheostomy was removed without any complication. During one-year follow up, no sequelae were observed.
一位35岁的女性出现了巨大的舌头肿大。自从一周前她的舌头突然变大,最终不适合她的嘴以来,她就一直患有这个问题。注意到儿童时期的慢性舌头肿大。患者有精神病史,即脑瘫,由于无法行走,她只能坐轮椅。此外,由于严重的脊柱侧弯,右肺不张。在初步评估后不久,她被抬到手术室,由于她无法躺到仰卧位,用刚性喉镜以坐姿插管。在整个过程中,病人服用了镇静剂。之后,进行了气管造口术。5天后,未观察到舌头大小的改善。医疗委员会对诊断进行了修订,尽管有炎症病理,但还是切除了隆起的舌头。康复后,患者可耐受口服喂养,出院后总体健康状况良好。一周后,气管造口术形成的气道被切除,没有任何并发症。在一年的随访中,没有观察到后遗症。
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引用次数: 0
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Case Reports in Clinical Practice
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