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The role of p63 myoepithelial cell marker in problematic breast lesion p63肌上皮细胞标记物在乳腺病变中的作用
Pub Date : 2023-01-01 DOI: 10.4103/hmj.hmj_78_23
Sufian Zaheer, Durre Aden, Nishat Afroze, Aaliya Ehsan, Zainab Hassan, Meher Aziz
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引用次数: 0
Aphonia following general anaesthesia 全身麻醉后失音
Pub Date : 2023-01-01 DOI: 10.4103/hmj.hmj_95_22
Shweta Dhiman, AnjuRomina Bhalotra
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引用次数: 0
Retrospective analysis of maternal near miss and the applicability of previous caesarean section delivery as a predictor of risk at a tertiary level hospital of India 印度一家三级医院产妇未遂事件的回顾性分析及既往剖腹产作为风险预测指标的适用性
Pub Date : 2023-01-01 DOI: 10.4103/hmj.hmj_69_22
J. Biswas, M. Datta, K. Kar, Divyangana Mitra, P. Reddy, Anti Biswas
Background: Caesarean section (CS) rate is showing an alarming increase in India, as a result, high-risk pregnancies with previous CS are becoming more frequent. Objective: The present study compared the additional risk for previous CS among a retrospective cohort of women who had maternal near miss (MNM). Materials and Methods: Record analysis of women with MNM between April 2019 and March 2020 at the tertiary level teaching hospital of Kolkata, India. Data for the selected study variables were extracted from the patient's case record forms. The main outcome measures were crude odd's ratio for risk of post-partum haemorrhage (PPH), repeat CS and adverse birth outcome; difference of mean for units of blood products transfused, number of clinical signs and hospital stay and adjusted odds ratio for PPH. Results: In this study, 100 records were analysed. The mean age of the cohort was 27.65 years with a standard deviation (SD) of 6.25 years. Forty women had previous CS, among whom 27 (67.5%) had a single CS while 13 (32.5%) had CS twice. A number of clinical signs, duration of hospital stay, total units of packed red cells (PRBCs) and total units of blood products transfused were similar between the groups. Women with previous CS had a significantly higher risk for PPH and having a repeat CS in the present pregnancy. CS at the present pregnancy was the only predictor for PPH after adjusting for other variables. Conclusion: It is difficult to ascertain whether a patient's antepartum and intrapartum course prior to delivery is responsible for the patient's morbidity, or if the previous CS is responsible for some component of the adverse outcomes. Repeated, poor-quality, repeated, closely-spaced CS, can likely result in maternal morbidity, especially PPH. The effect of CS not only affects the incident pregnancy, but future ones as well.
背景:在印度,剖腹产(CS)率呈惊人的增长,因此,有CS病史的高危妊娠越来越频繁。目的:本研究比较了母亲未遂事故(MNM)妇女的回顾性队列中既往CS的额外风险。材料和方法:2019年4月至2020年3月在印度加尔各答三级教学医院对MNM女性的记录分析。所选研究变量的数据从患者的病例记录表中提取。主要的结果指标是产后出血(PPH)风险的粗略奇数比、重复CS和不良分娩结果;输注血液制品单位、临床症状数和住院时间的平均值差异,以及PPH的调整比值比。结果:在这项研究中,分析了100份记录。该队列的平均年龄为27.65岁,标准差(SD)为6.25岁。40名女性既往有CS,其中27名(67.5%)有一次CS,13名(32.5%)有两次CS。两组之间的许多临床症状、住院时间、堆积红细胞(PRBCs)的总单位和输注的血液制品的总单位相似。既往患有CS的女性患PPH的风险明显更高,并且在本次妊娠中再次发生CS。在调整了其他变量后,目前妊娠期的CS是PPH的唯一预测因素。结论:很难确定患者分娩前的产前和产时过程是否是导致患者发病的原因,或者之前的CS是否是导致不良结果的部分原因。重复的、质量差的、重复的、间隔很近的CS可能会导致产妇发病,尤其是PPH。CS的影响不仅会影响意外怀孕,还会影响未来的怀孕。
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引用次数: 1
Large mesenteric cyst from the small bowel mesentery in a young pregnant female with calcular cholecystitis 患有结石性胆囊炎的年轻怀孕女性的小肠肠系膜大肠系膜囊肿
Pub Date : 2023-01-01 DOI: 10.4103/hmj.hmj_74_22
A. Al Ghrebawi, Salah Ibrahim, Gehad Bashir
Rationale: Mesenteric cysts are rare abdominal tumours that can originate from any part of the mesentery of the bowel but have been found mostly in the mesentery of the small bowel. Patient Concerns: Because they lack specific clinical signs, mesenteric cysts can be difficult to diagnose. Diagnosis: Especially when there are concomitant abdominal conditions. In some circumstances, these cysts can grow to considerable sizes making resection almost impossible as different structures can be compromised. Intervention: Surgery is the treatment of choice as complete resection is the only curative treatment. Outcome: We present the case of a 27-year-old pregnant female patient who presented with recurrent abdominal pain and was discovered to have calcular cholecystitis along with a huge mesenteric cyst. She underwent laparoscopic cholecystectomy with complete excision of the mesenteric cyst without the need for bowel resection and anastomosis.
理由:肠系膜囊肿是一种罕见的腹部肿瘤,可起源于肠系膜的任何部位,但主要发现于小肠系膜。患者担忧:由于缺乏特定的临床症状,肠系膜囊肿可能难以诊断。诊断:尤其是当伴有腹部疾病时。在某些情况下,这些囊肿可以长到相当大的尺寸,使得切除几乎不可能,因为不同的结构可能会受到损害。干预:手术是治疗的选择,因为完全切除是唯一的治疗方法。结果:我们报告了一例27岁的孕妇,她表现为反复腹痛,并被发现患有结石性胆囊炎和巨大的肠系膜囊肿。她接受了腹腔镜胆囊切除术,完全切除了肠系膜囊肿,无需进行肠道切除和吻合。
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引用次数: 0
Assessment of the Hepatotoxicity of Intratracheally Instilled Silver Nanoparticles in Hypertensive Mice 气管内注射银纳米粒子对高血压小鼠肝毒性的评估
Pub Date : 2023-01-01 DOI: 10.4103/hmj.hmj_80_22
A. Nemmar, S. Al-Salam, S. Beegam, N. Zaaba, Ozaz Elzaki, J. Yasin, B. Ali
Background: Silver nanoparticles (AgNPs) are extensively used in numerous engineering and biomedical fields. Inhaled nanoparticles can induce lung inflammation and translocate into secondary organs including the liver. However, the possible impact of these nanoparticles on the liver received only scant attention, especially following intratracheal (i.t.) instillation in an animal model of hypertension. Aims and Objectives: Here, we evaluated the hepatotoxicity and mechanism of action of polyethylene glycol (PEG)-coated AgNPs in a mouse model of hypertension. Materials and Methods: Mice were made hypertensive (HT) by inserting osmotic minipump infusing angiotensin II (ANG II) or vehicle (control) normotensive (NT). Either saline (control) or PEG-AgNPs (0.5 mg/kg) were i.t. instilled on days 7, 14, 21 and 28 post-ANG II or vehicle infusion. Twenty-four hours after the last exposure (day 29), lung histopathology and several markers of liver function, inflammation, oxidative stress, DNA damage and apoptosis were evaluated in all mice. Results: In comparison with either saline-treated HT group or PEG-AgNPs-treated NT group, lung histology of PEG-AgNPs-treated HT mice showed more focal areas of widening of interalveolar septae with inflammatory cells consisting mainly in macrophages and neutrophil polymorphs. In PEG-AgNPs-treated HT mice, the activities of lactate dehydrogenase, aspartate transaminase, alanine transaminase, gamma-glutamyl transferase and alkaline phosphatase in plasma were increased, compared with either saline-treated HT or PEG-AgNPs-treated NT mice. Similarly, markers of hepatic oxidative stress (lipid peroxidation, glutathione and catalase), inflammation (interleukin [IL]-6, IL-1 β and tumour necrosis factor α), DNA damage (8-hydroxy-2′-deoxyguanosine) and apoptosis (cleaved caspase-3) were significantly increased in PEG-AgNPs-treated HT mice, compared with either saline-treated HT or PEG-AgNPs-treated NT mice. Conclusion: Our data provide novel evidence on the aggravation of liver damage following pulmonary administration of PEG-AgNPs in hypertension through mechanisms involving inflammation oxidative stress, DNA damage and apoptosis.
背景:银纳米粒子(AgNPs)广泛应用于许多工程和生物医学领域。吸入的纳米颗粒可以诱导肺部炎症并转移到包括肝脏在内的次要器官。然而,这些纳米颗粒对肝脏的可能影响很少受到关注,尤其是在高血压动物模型中气管内(i.t.)滴注之后。目的和目的:在此,我们评估了聚乙二醇(PEG)包被的AgNPs在高血压小鼠模型中的肝毒性和作用机制。材料和方法:小鼠通过插入微渗透泵输注血管紧张素II(ANG II)或载体(对照)血压正常(NT)制备高血压(HT)。在ANG II或载体输注后第7、14、21和28天,静脉滴注生理盐水(对照)或PEG-AgNPs(0.5mg/kg)。最后一次暴露后24小时(第29天),对所有小鼠的肺组织病理学和肝功能、炎症、氧化应激、DNA损伤和细胞凋亡的几种标志物进行了评估。结果:与生理盐水处理的HT组或PEG-AgNPs处理的NT组相比,PEG-AgNP处理的HT小鼠的肺组织学显示更多的脑室间隔膜增宽的局灶性区域,炎性细胞主要由巨噬细胞和中性粒细胞多晶型组成。在PEG-AgNPs处理的HT小鼠中,与盐水处理的HT或PEG-AgNP处理的NT小鼠相比,血浆中乳酸脱氢酶、天冬氨酸转氨酶、丙氨酸转氨酶、γ-谷氨酰转移酶和碱性磷酸酶的活性增加。类似地,与盐水处理的HT或PEG-AgNPs处理的NT小鼠相比,PEG-AgNP处理的HT小鼠的肝脏氧化应激(脂质过氧化、谷胱甘肽和过氧化氢酶)、炎症(白细胞介素[IL]-6、IL-1β和肿瘤坏死因子α)、DNA损伤(8-羟基-2′-脱氧鸟苷)和凋亡(裂解的胱天蛋白酶-3)的标志物显著增加。结论:我们的数据通过炎症、氧化应激、DNA损伤和细胞凋亡等机制,为高血压患者肺给药后肝损伤的加重提供了新的证据。
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引用次数: 0
Intrahepatic biliary cystadenoma with mesenchymal (ovarian) stroma in an elderly female: A rare entity 老年女性肝内胆道囊腺瘤合并间质(卵巢)间质:罕见病例
Pub Date : 2023-01-01 DOI: 10.4103/hmj.hmj_39_23
Sabina Khan, Nehal Ahmad, Rubeena Mohroo, Sujata Jetley
Rationale: Intrahepatic Biliary cystadenoma is a family of rare cystic neoplasms of liver that accounts for less than 5% of nonparasitic hepatic cystic lesions. It usually occurs in middle-aged females. It is a slowly growing benign tumor with nonspecific clinical manifestations that has malignant potential, especially those with mesenchymal ovarian stroma. Patient Concerns: 42-year-old female who presented in OPD with right upper abdominal pain associated with vomiting that was clinico-radiologically diagnosed as Hydatid cyst of the liver. Diagnosis: Exploratory laparotomy was done for the cystic lesion present in the left lobe of liver and the excised cystic tissue piece was sent for histopathological examination. A final diagnosis of Intrahepatic biliary cystadenoma with mesenchymal stroma was made after thorough histopathological examination. Interventions: Deroofing of the cyst with partial capitonnaging with omentopexy was done. Outcome: Our patient was followed up after management and since then no abnormality or sign of recurrence was seen. This also relates to its good prognostic value. Lessons: Intrahepatic Biliary cystadenoma with mesenchymal stroma, when compared to other benign cystic lesion of the liver, have more chances of recurrence as well as malignant transformation if not completely excised. Therefore, through this case report we wish to raise awareness amongst clinicians regarding this rare cystic lesion of liver especially when surgical management of hepatic cystic lesions is considered.
理由:肝内胆道囊腺瘤是一种罕见的肝脏囊性肿瘤,占非寄生虫性肝囊性病变的不到5%。它通常发生在中年女性身上。它是一种生长缓慢的良性肿瘤,临床表现非特异性,有恶性潜能,尤其是伴有卵巢间质间质的肿瘤。患者关注:42岁女性,因右上腹部疼痛伴呕吐就诊于门诊,临床放射诊断为肝包虫病。诊断:肝左叶囊性病变行开腹探查,切除囊性组织块行组织病理学检查。最终诊断为肝内胆道囊腺瘤合并间质间质瘤是经过彻底的组织病理学检查。干预措施:用网膜固定术对囊肿进行部分资本化去除。结果:我们的患者在治疗后随访,此后未见异常或复发迹象。这也与其良好的预后价值有关。结论:肝内胆道囊腺瘤合并间充质间质,如果不完全切除,其复发和恶性转化的几率高于肝脏其他良性囊性病变。因此,通过本病例报告,我们希望提高临床医生对这种罕见的肝脏囊性病变的认识,特别是在考虑肝囊性病变的手术治疗时。
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引用次数: 0
Renal replacement lipomatosis and xanthogranulomatous pyelonephritis: A rare coexistence 肾脏替代脂肪瘤病和黄色肉芽肿性肾盂肾炎:罕见的共存
Pub Date : 2023-01-01 DOI: 10.4103/hmj.hmj_57_23
Sana Ahuja, NehaKawatra Madan, Meetu Agrawal
Xanthogranulomatous pyelonephritis (XGP) is a granulomatous inflammation caused by chronic infection. Renal replacement lipomatosis represents a condition in which there is extensive proliferation of fat within the perirenal space and renal sinus, replacing the renal parenchyma. Coexistence of XGP and replacement lipomatosis in the same kidney is a very rare phenomenon. We report a rare such case with gross, histopathological and immunohistochemical findings in a 61-year-old male patient who presented with gross haematuria and right flank pain.
黄色肉芽肿性肾盂肾炎(XGP)是由慢性感染引起的肉芽肿性炎症。肾脏替代脂肪瘤病是指肾周间隙和肾窦内脂肪广泛增生,取代肾实质的一种疾病。同一肾脏同时存在XGP和替代脂肪瘤病是一种非常罕见的现象。我们报告一例罕见的此类病例,其大体、组织病理学和免疫组织化学发现为61岁男性患者,其表现为大体血尿和右侧疼痛。
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引用次数: 0
Role of fine-needle aspiration cytology as an inexpensive tool for diagnosis of idiopathic granulomatous mastitis 细针穿刺细胞学作为特发性肉芽肿性乳腺炎廉价诊断工具的作用
Pub Date : 2023-01-01 DOI: 10.4103/hmj.hmj_42_23
Saikat Bhattacharya, Aniket Halder, Sumanta Bhattacharya, TapanJyoti Banerjee
Introduction: Idiopathic granulomatous mastitis (IGM) is a benign chronic inflammatory disease of the breast. The diagnosis depends on histopathological examination after ruling out all other diseases causing granulomatous lesions. Although diagnosis by cytology is a challenging task, especially in a tuberculosis-prevalent country, it helps in early diagnosis if certain protocols are followed and helps to avoid the complications related to biopsy. Aims and Objective: In this study, 52 cases of IGM were followed retrospectively to analyse the cytological findings, which are helpful for a conclusive diagnosis of the disease. Materials and Methods: An institution-based retrospective observational study conducted over a period of 7 years, and patients with histologically proven cases of granulomatous mastitis were selected for this study. Fifty-two cases were analysed. For cytologic evaluation, parameters evaluated were – (1) presence of granulomas, (2) predominant cell of infiltration, (3) presence of fibrocapillary fragments, (4) presence or absence of caseation necrosis, (5) morphology of multinucleated giant cells and if present, (6) ductal cells – normal or atypical. Statistical Analysis: Conducted in MS Excel and R 4.2.1. Results: Epithelioid cell granuloma is the most consistent finding, as it was present in 90% of cases. Other findings such as neutrophilic infiltrate (76.9%), presence of fibrocapillary fragments (86.5%), absence of caseation necrosis (98.1%) and lack of ductal cell atypia (94.2%) carry significance in diagnosis. Conclusion: Cytological findings such as epithelioid cell granulomas with the absence of caseation necrosis, predominant neutrophilic infiltrates, presence of fibrocapillary fragments and absence of ductal cell atypia when collaborated with special stains for fungus and acid-fast bacilli, will correctly help in diagnosing IGM by fine-needle aspiration cytology.
简介:特发性肉芽肿性乳腺炎(IGM)是一种乳腺良性慢性炎症性疾病。诊断依赖于组织病理学检查后,排除所有其他疾病引起肉芽肿病变。虽然细胞学诊断是一项具有挑战性的任务,特别是在结核病流行的国家,但如果遵循某些方案,它有助于早期诊断,并有助于避免与活检有关的并发症。目的和目的:回顾性分析52例IGM患者的细胞学表现,为本病的明确诊断提供依据。材料和方法:一项以机构为基础的回顾性观察研究,进行了为期7年的研究,并选择了组织学证实的肉芽肿性乳腺炎患者。分析了52例病例。对于细胞学评估,评估的参数是(1)肉芽肿的存在,(2)浸润的主要细胞,(3)纤维毛细血管碎片的存在,(4)干酪化坏死的存在或不存在,(5)多核巨细胞的形态,如果存在,(6)导管细胞-正常或非典型。统计分析:在MS Excel和r4.2.1中进行。结果:上皮样细胞肉芽肿是最一致的发现,因为它存在于90%的病例。其他表现如中性粒细胞浸润(76.9%)、纤维毛细血管碎片(86.5%)、无干酪样坏死(98.1%)和无导管细胞异型性(94.2%)对诊断具有重要意义。结论:细针抽吸细胞学检查结果为上皮样细胞肉芽肿,无干酪样坏死,中性粒细胞浸润为主,有纤维毛细血管碎片,无导管细胞异型,配合真菌和抗酸杆菌的特殊染色,可正确诊断IGM。
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引用次数: 0
Agenda setting of 'sexual harassment of women at workplace act, 2013:' an analysis of decadal training programme of healthcare providers on gender-based violence 制定《2013年工作场所对妇女性骚扰法》的议程:对医疗保健提供者关于性别暴力问题的十年培训方案的分析
Pub Date : 2023-01-01 DOI: 10.4103/hmj.hmj_31_23
Meerambika Mahapatro, MokshM Prasad, Uplabdhi Sahu
Background: Training of healthcare providers on gender-based violence has emerged as a way of teaching them how to address gender-based health inequalities in their work. For a long time, the National Institute of Health and Family Welfare (NIHFW) has been training healthcare professionals on gender-based violence (GBV) and policy-related issues. Aims and Objectives: The article tries to document the analysis of the decadal training programme on GBV by NIHFW on various aspects of the trainees nominated by the state health authorities or policymakers in India, with a focus on the changing scenario before and after the enactment of the Sexual Harassment of Women at Workplace Act, 2013. Materials and Methods: The study design was a descriptive cross-sectional analysis of secondary data from 10 years gathered by NIHFW. A total of 250 healthcare providers were nominated from different states of India by the higher authorities to attend the training programme. Participants’ variables such as sex, professional qualifications and feedback in terms of narratives were analysed to compare issues that emerged before and after the enactment of the Act. Results: Two phenomena impede gender mainstreaming in the healthcare system. First, women’s participation with a limited male nomination in the gender training programmes inherently reinforces stereotypes of gender roles in the healthcare system. Second, gender training has yet to entail medical professionals’ participation, so it remains that gender is a ‘non medical’ social concern for the health professional. Conclusion: In order to achieve policy objectives, the capacity to integrate the gender divide across healthcare professionals is essential. While medical and non-medical convergence is critical in light of the health consequences of GBV, the continued exclusion of men from the capacity-building strategy will impede seamless policy implementation and gender-sensitive internalisation of organisational behaviours.
背景:对保健提供者进行关于基于性别的暴力的培训已成为一种教育他们如何在工作中解决基于性别的保健不平等问题的方法。长期以来,国家卫生和家庭福利研究所(NIHFW)一直在就基于性别的暴力和与政策有关的问题对卫生保健专业人员进行培训。目的和目标:本文试图记录NIHFW对印度国家卫生当局或政策制定者提名的受训者各方面性别暴力问题十年培训方案的分析,重点关注2013年《工作场所妇女性骚扰法》颁布前后不断变化的情况。材料和方法:本研究设计是对NIHFW收集的10年二手资料进行描述性横断面分析。上级当局从印度不同的邦共提名了250名保健提供者参加培训方案。分析了参与者的变量,如性别、专业资格和叙述方面的反馈,以比较该法案颁布前后出现的问题。结果:两种现象阻碍了卫生保健系统中的性别主流化。首先,女性参与性别培训项目,而男性提名有限,这从本质上强化了医疗系统中性别角色的刻板印象。第二,性别问题培训尚未涉及医疗专业人员的参与,因此性别问题仍然是卫生专业人员的"非医学"社会关切。结论:为了实现政策目标,在保健专业人员之间整合性别差异的能力至关重要。鉴于性别暴力对健康造成的后果,医疗和非医疗融合至关重要,但继续将男子排除在能力建设战略之外将妨碍政策的无缝执行和对性别问题敏感的组织行为内部化。
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引用次数: 0
Assessment of glycaemic control and associated factors among types 2 diabetes mellitus patients attending outpatients department clinic of Kubwa general hospital, Abuja 阿布贾库巴总医院门诊2型糖尿病患者血糖控制及相关因素评估
Pub Date : 2023-01-01 DOI: 10.4103/hmj.hmj_120_22
Olaolorunpo Olorunfemi, OgunleyeGrace Adedunmade
Background: Glycaemic management is crucial to the effective treatment of type 2 diabetes mellitus (DM) because it reduces or eliminates Complications caused by diabetes. Aims and Objectives: To evaluate glycaemic control and the factors that contributed to it. Materials and Methods: The study employed a cross-sectional hospital-based descriptive research design, and 190 patients with type 2 DM were selected through a systematic sampling process. Data were gathered using a self-administered questionnaire and validated in accordance with the study’s specific objectives. The acquired data were coded, put into SPSS (version 21.0 Inc., Chicago IL, USA), and subjected to Chi-square testing and descriptive analysis with a 0.05 level of significance. Results: More than half of the respondents, 64.2%, had substantial risk factors for poor glycaemic control, and the majority of respondents, 60.0%, had poor glycaemic control. The contributing factors to poor glycaemic control were patients who had been coming to the clinic for more than 10 years, poor medication adherence, forgetting to take their prescription and stopping their medication when their symptoms were under control. The study also found a significant (P = 0.05) correlation between haemoglobin A1c level, age and household income. Conclusion: Amazingly, 60.5% of patients with type 2 diabetes had inadequate glycaemic control. Age and low monthly household income compared with the cost of medications were found to have a major impact on glycaemic control. Therefore, we recommend that the government of Nigeria needs to subsidise the cost of DM medication and establish a policy and environment that will promote a better blood glucose control among people with diabetes.
背景:血糖管理对2型糖尿病(DM)的有效治疗至关重要,因为它可以减少或消除糖尿病引起的并发症。目的和目的:评价血糖控制及影响血糖控制的因素。材料与方法:本研究采用基于医院的横断面描述性研究设计,通过系统抽样方法选择190例2型糖尿病患者。数据采用自我管理的问卷收集,并根据研究的具体目标进行验证。对所得数据进行编码,放入SPSS (version 21.0 Inc., Chicago IL, USA)软件中,卡方检验和描述性分析,显著性水平为0.05。结果:超过一半的受访者(64.2%)存在严重的血糖控制不良危险因素,大多数受访者(60.0%)血糖控制不良。导致血糖控制不佳的因素是就诊时间超过10年的患者、服药依从性差、忘记服药以及在症状得到控制后停药。研究还发现,血红蛋白A1c水平与年龄和家庭收入之间存在显著相关性(P = 0.05)。结论:令人惊讶的是,60.5%的2型糖尿病患者血糖控制不足。年龄和较低的家庭月收入与药物费用相比,被发现对血糖控制有主要影响。因此,我们建议尼日利亚政府需要补贴糖尿病药物的费用,并建立政策和环境,以促进糖尿病患者更好地控制血糖。
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引用次数: 0
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Hamdan Medical Journal
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