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The driving factors facilitating non-medical use of tramadol: a qualitative study of Nigerian youths 促进曲马多非医疗使用的驱动因素:对尼日利亚青年的定性研究
Pub Date : 2023-06-20 DOI: 10.32457/ijmss.v10i2.2128
I. Molobe, V. Yesufu, I. Idigbe
Background: The paper explores the opinions of Nigerian youth regarding their reasons behind the use of tramadol for non-medical purposes and learns their preferences in choosing tramadol. Methods: We conducted In-depth Interviews (IDIs) and Focus Group Discussions (FGDs) among students in secondary schools, tertiary schools and out-of-school youths in Lagos, Ekiti, Edo and Delta states in Nigeria. A total of 20 IDIs and 6 FGDs were conducted among 92 Nigerian youths of age 15 – 25 years. Data was also complemented from school reports, participants’ feedback from youth drug abuse sensitization workshops and desk reviews. Data were analyzed using thematic analysis to describe emerging themes. Results: The sex distribution of the participants was 60.1% males and 39.1% females. The main findings for non-medical use of tramadol among the youths were; to enhance sexual excitement (prolong ejaculation), to feel less hungry (reduce the desire for and food) to sustain hard labor (reduce pain, withstand prolong manual labor). The respondents also revealed that tramadol in combination with other substances will give them a euphoric effect. However, many of youths are ignorant of the risk of the non-medical use of tramadol. Conclusion: Tramadol abuse has become widespread in the Nigerian environment among the youths. The findings from this study revealed that the choice of tramadol use for non-medical purposes is a result of different effects discovered in the use which could pose potential harm to the abuser. Therefore, public health approaches should be adopted in preventing the abuse of tramadol among the youth.
背景:本文探讨了尼日利亚青年的意见关于他们的原因背后使用曲马多的非医疗目的,并了解他们的偏好在选择曲马多。方法:我们对尼日利亚拉各斯、埃基蒂、埃多和三角洲州的中学、大学学生和失学青年进行了深度访谈(IDIs)和焦点小组讨论(FGDs)。在92名15 - 25岁的尼日利亚青年中,共进行了20次IDIs和6次fgd。数据还得到了学校报告、青少年药物滥用敏感化讲习班参与者的反馈和案头审查的补充。数据分析采用专题分析来描述新出现的主题。结果:参与者的性别分布为男性60.1%,女性39.1%。青少年非医疗使用曲马多的主要发现是;增强性兴奋(延长射精时间),减少饥饿感(减少对食物的渴望),维持艰苦的劳动(减轻疼痛,承受延长体力劳动)。受访者还透露,曲马多与其他物质结合会给他们带来愉悦的效果。然而,许多年轻人对曲马多非医疗使用的风险一无所知。结论:曲马多的滥用在尼日利亚的青少年中非常普遍。这项研究的结果表明,选择曲马多用于非医疗目的是由于在使用过程中发现的不同效果可能对滥用者造成潜在伤害。因此,应采取公共卫生措施防止青少年滥用曲马多。
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引用次数: 0
Vol. 10 No. 2 (2023): June, 2023 第10卷第2期(2023):2023年6月
Pub Date : 2023-06-20 DOI: 10.32457/ijmss.v10i2
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引用次数: 0
Approach of Preeclampsia without Signs of Severity 没有严重征兆的先兆子痫的方法
Pub Date : 2023-06-20 DOI: 10.32457/ijmss.v10i2.2116
Jesús Nicolás Larco-Coloma, Diana Brigitte Ágreda-Saraguro, Cinthya Victoria Bailón-Pereira, Stephany Granja-Casanova, Eduardo Javier Eduardo Javier, Francisco Xavier Cevallos-Ariza
Preeclampsia represents one of the main causes of death in pregnancy, worldwide the WHO indicates that 20% of maternal deaths are caused by hypertensive problems. The problems that represent the highest risk index are hypertension and proteinuria, which are often generated from the 20th week of gestation, up to six weeks after delivery, values that generate a rapid increase of serious complications in preeclampsia including the death of the mother and fetus, However, if the gestational age of the fetus exceeds 36 weeks, the best treatment is the induction of labor, because it reduces the risk of complications, however if it is less than 33 weeks, expectant management including imaging, laboratory and welfare studies for the fetus should be initiated. Thus, it is of significant importance the study that provides the best prenatal control, diagnosis and adequate management of this disease, which are the most effective measures to reduce the mortality rate due to this cause.References
子痫前期是妊娠期死亡的主要原因之一,世界卫生组织指出,全世界20%的孕产妇死亡是由高血压问题引起的。代表最高的风险指数的问题是高血压和蛋白尿,通常产生的妊娠20周,6周后交付,值生成一个快速增长的子痫前期严重的并发症,包括母亲和胎儿的死亡,然而,如果胎儿的胎龄超过36周,最好的治疗方法是引产术,因为它可以减少并发症的风险,但是如果小于33周,应开始对胎儿进行影像学、实验室和福利研究等待产管理。因此,研究提供最好的产前控制、诊断和适当的治疗,这是减少因这一原因造成的死亡率的最有效措施,具有重要意义。参考文献
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引用次数: 0
Rhino-Orbito-Cerebral Mucormycosis associated with COVID-19. Case report and literature review 与COVID-19相关的鼻-眶-脑毛霉菌病。病例报告及文献复习
Pub Date : 2023-06-20 DOI: 10.32457/ijmss.v10i2.2156
Rodrigo González Insfrán, Raúl Tornaco, Alberto Lezcano Machi, Enrique Pérez Girala, Carlos Mena Canata
La rinosinusitis fúngica invasiva aguda es una entidad infecciosa poco frecuente, con alta mortalidad (50-80%), caracterizada por angioinvasión primaria, trombosis, isquemia y necrosis. Puede deberse a hongos Zygomycetes (como el Mucor) y Aspergillus. Se ve en pacientes con inmunocompromiso como diabéticos mal controlados, neoplasias hematológicas, régimen quimioterápico, síndrome de inmunodeficiencia adquirida y trasplantados. Se presenta un caso de Mucormicosis RinoOrbito-Cerebral en una paciente con antecedente de Síndrome de Dificultad Respiratoria Severa por el Nuevo Coronavirus y posteriormente se revisa la literatura pertinente.
急性侵袭性真菌性鼻窦炎是一种罕见的感染实体,死亡率高(50-80%),以原发性血管浸润、血栓形成、缺血和坏死为特征。它可能是由接合真菌(如粘液)和曲霉引起的。在免疫功能受损的患者中,它被视为控制不良的糖尿病、血液系统肿瘤、化疗方案、获得性免疫缺陷综合征和移植。本研究的目的是评估一种新型冠状病毒引起的鼻脑毛霉病的临床表现。
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引用次数: 0
Inflammatory and endothelial dysfunction markers in hypertensive patients with type 2 diabetes mellitus 高血压合并2型糖尿病患者的炎症和内皮功能障碍标志物
Pub Date : 2023-06-20 DOI: 10.32457/ijmss.v10i2.2190
Diego Tene, J. Robalino, A. Pedreáñez
Hypertension and diabetes are two of the main risk factors for the development of cardiovascular disease, and both pathologies overlap significantly in their pathophysiological mechanisms. The aim of this study was to determine the concentration of inflammatory markers and endothelial dysfunction in patients with hypertension and type 2 diabetes mellitus, to compare with healthy individuals, and to determine whether the coexistence of both pathologies has a different effect on the behavior of these markers. A descriptive, correlational, cross-sectional research was carried out from July 2022 to February 2023. A total of 120 individuals were selected for this study (30 controls, 30 with type 2 diabetes mellitus, 30 with hypertension and 30 with diabetes plus hypertension). Each subject had a fasting blood sample drawn for determination of total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol, ultrasensitive C-reactive protein (hs-CRP), glycosylated hemoglobin, sICAM-1, sE-selectin, IL-6 and TNF-α. A significant increase in the concentration of sICAM-1, sE-selectin, IL-6 and TNF-α was found in diabetic, hypertensive and diabetic patients with hypertension when compared to controls (p<0.0001). The coexistence of diabetes and hypertension did not represent a significant elevation in the concentration of markers of endothelial dysfunction and inflammation. In conclusion, our results suggest endothelial activation as well as an inflammatory state in patients with diabetes and hypertension, indicated by elevated levels of circulating adhesion molecules and proinflammatory cytokines. The simultaneous presence of diabetes and hypertension did not have an additive effect on the levels of these molecules.
高血压和糖尿病是心血管疾病发生的两个主要危险因素,两种病理在病理生理机制上有明显的重叠。本研究的目的是确定高血压和2型糖尿病患者的炎症标志物和内皮功能障碍的浓度,并与健康人群进行比较,并确定两种病理的共存是否对这些标志物的行为有不同的影响。从2022年7月到2023年2月进行了一项描述性、相关性、横断面研究。本研究共选取120人(对照组30人,2型糖尿病患者30人,高血压患者30人,糖尿病合并高血压患者30人)。每位受试者空腹采血,测定总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、超敏c反应蛋白(hs-CRP)、糖化血红蛋白、sICAM-1、硒选择素、IL-6和TNF-α。糖尿病、高血压及糖尿病合并高血压患者血清中sICAM-1、硒选择素、IL-6、TNF-α的浓度较对照组显著升高(p<0.0001)。糖尿病和高血压共存并不代表内皮功能障碍和炎症标志物浓度的显著升高。总之,我们的研究结果表明,糖尿病和高血压患者的内皮细胞激活和炎症状态,表现为循环黏附分子和促炎细胞因子水平升高。糖尿病和高血压同时存在对这些分子的水平没有叠加效应。
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引用次数: 0
Arteriovenous fistula, pulmonary hypertension, and tricuspid dysfunction in renal transplant recipients. A possible solution 肾移植受者的动静脉瘘、肺动脉高压和三尖瓣功能障碍。一个可能的解决方案
Pub Date : 2023-06-02 DOI: 10.32457/ijmss.v10i1.2065
R. C. Cruz Abascal, José Ignacio Ramírez Gómez, Carlos Genaro Gutiérrez Gutiérrez, Lisbel Pérez Delgado
Introduction: Cardiovascular dysfunction is the first cause of death in patients with chronic kidney disease.Methods: Observational, longitudinal and prospective study, which included 58 patients with functioning renal transplant who were studied different echocardiographic variables, before and six months after the closure of the arteriovenous fistula.Results: The average age was 46.62 years and the most frequent was male 30 (51.72%). The flow of angioaccesses at the wrist level was demonstrated in 28 patients (45.9%) with evidence of regression of mean pulmonary artery pressure from 25.56 to 19.58 mmHg (p=0.002), more connoted for those of intermediate flow; 14. Also, the area of tricuspid insufficiency was greater for that group; from 3.15 to 1.96 cm2 (p=0.001). The pattern of mild dysfunction was observed in 38 patients (62.3%) prior to closure. Subsequent to this 27; (51.9%), exhibited minimal valvular insufficiency and 9 individuals (14.9%) did not show any degree of valvular dysfunction.Conclusions: Closure of the arteriovenous fistula in patients with functioning renal transplantation contributed to decrease the risk of pulmonary hypertension and progression of tricuspid valve dysfunction.
简介:心血管功能障碍是慢性肾病患者死亡的首要原因。方法:观察性、纵向和前瞻性研究,纳入58例功能性肾移植患者,研究动静脉瘘关闭前和关闭后6个月的不同超声心动图变量。结果:患者平均年龄46.62岁,以30岁男性居多,占51.72%。28例患者(45.9%)出现手腕水平的血管通路血流,平均肺动脉压从25.56降至19.58 mmHg (p=0.002),中间血流的患者更为明显;14. 另外,三尖瓣功能不全的面积也更大;从3.15到1.96 cm2 (p=0.001)。38例患者(62.3%)在关闭前出现轻度功能障碍。在这之后27;(51.9%)表现出轻微的瓣膜功能不全,9人(14.9%)没有表现出任何程度的瓣膜功能障碍。结论:功能肾移植患者关闭动静脉瘘有助于降低肺动脉高压和三尖瓣功能障碍进展的风险。
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引用次数: 0
Incidence of complications in patients with spontaneous subarachnoid hemorrhage 自发性蛛网膜下腔出血患者并发症的发生率
Pub Date : 2023-06-02 DOI: 10.32457/ijmss.v10i1.2074
Mercedes Soledad Corona Fonseca, Ada Sánchez Lozano, Ernesto Castro López, Luis Alberto Corona Martínez
The occurrence of complications affects the evolution and darkens the prognosis of patients with spontaneous subarachnoid hemorrhage. The objective was to determine the incidence of neurological and non-neurological complications in a series of patients with spontaneous subarachnoid hemorrhage. An observational, descriptive-correlational and retrospective study of 96 patients with spontaneous subarachnoid hemorrhage between 2016 and 2021 was carried out. The frequency of different neurological and non-neurological complications was determined, as well as the relationship between the presence of neurological complications and other variables through analysis. bivariate (Odds Ratio and its confidence interval). Among the results it is found that 53% of the patients presented some type of neurological complication, which prevailed in those 60 years of age or older (62% vs 45%), in aneurysmal etiology (54% vs 27%) and when the diagnosis was made. in the first 48 hours of the onset of symptoms (56% vs 43%). The frequency of complicated patients increased from grade I to grade V on the Hunt and Hess scale (OR 30.6[8.2;113]), the same as on the Fisher scale (OR 11.6[3 ,1;43,2]). The most frequent neurological complication was intracranial hypertension (39%), while the non-neurological one was pneumonia (24%). It is concluded that the series of patients was characterized by a high frequency of neurological complications, among which intracranial hypertension predominated. An evident relationship was demonstrated between the worst grades on the Hunt and Hess and Fisher imaging scales, obtained in the patient's assessment on admission, and the higher incidence of neurological complications.
并发症的发生影响自发性蛛网膜下腔出血患者病情的发展,使其预后恶化。目的是确定一系列自发性蛛网膜下腔出血患者的神经和非神经并发症的发生率。对2016年至2021年间96例自发性蛛网膜下腔出血患者进行了观察性、描述性相关和回顾性研究。通过分析,确定不同神经系统和非神经系统并发症的发生频率,以及神经系统并发症的发生与其他变量的关系。双变量(优势比及其置信区间)。结果发现,53%的患者出现某种类型的神经系统并发症,主要见于60岁及以上的患者(62%对45%)、动脉瘤病因(54%对27%)和诊断时。在症状出现的前48小时内(56%对43%)。Hunt and Hess评分从I级上升到V级(OR为30.6[8.2;113]),Fisher评分的OR为11.6[3,1;43,2])。最常见的神经系统并发症是颅内高压(39%),而非神经系统并发症是肺炎(24%)。结论:该系列患者的特点是神经系统并发症发生率高,其中以颅内高压为主。在患者入院时的评估中获得的Hunt, Hess和Fisher成像量表的最差评分与神经系统并发症的高发生率之间存在明显的关系。
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引用次数: 0
Artificial Intelligence in Human Medicine 人类医学中的人工智能
Pub Date : 2023-06-02 DOI: 10.32457/ijmss.v10i1.2150
Iván Suazo Galdames
This editorial reflects on the emergence of artificial intelligence and how it is applied in the field of health. AI is a technology that mimics the functioning of the human brain and uses algorithms, machine learning, pattern recognition and cognitive computing to process large amounts of data and extract useful insights. AI can improve health and well-being of people in various areas of medicine, such as medical image analysis, diagnosis, treatment, genetics, pregnancy and smart prosthetics. These applications can help medical professionals make better clinical decisions, accelerate research and development of new drugs, personalize patient care and reduce costs and human errors. AI can also empower users to access relevant information about their health and actively participate in their care. However, AI also poses ethical, legal and social challenges that must be addressed with responsibility and transparency.
这篇社论反映了人工智能的出现及其在卫生领域的应用。人工智能是一种模仿人类大脑功能的技术,它使用算法、机器学习、模式识别和认知计算来处理大量数据并提取有用的见解。人工智能可以在医学的各个领域改善人们的健康和福祉,如医学图像分析、诊断、治疗、遗传学、怀孕和智能假肢。这些应用程序可以帮助医疗专业人员做出更好的临床决策,加速新药的研究和开发,个性化患者护理,降低成本和人为错误。人工智能还可以使用户获得有关其健康的相关信息,并积极参与其护理。然而,人工智能也带来了道德、法律和社会挑战,必须以负责任和透明的方式应对。
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引用次数: 0
volumen 10, número 1 2023 第10卷第1期2023年
Pub Date : 2023-05-02 DOI: 10.32457/ijmss.v10i1
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引用次数: 0
Video Laryngoscopy as a Screening Tool for Laryngeal Changes in Chronic Smokers and Alcoholics 视频喉镜作为慢性吸烟者和酗酒者喉部病变的筛查工具
Pub Date : 2023-04-11 DOI: 10.1055/s-0043-1761619
P. S., G. K., N. B., Raghvi A., R. S
Abstract Aim and Objectives  The main aim of this study was to identify the evolving, early changes, premalignant and malignant lesions of larynx among smokers, and alcoholics by video laryngoscopy and to correlate the duration, frequency, and amount of smoking and alcohol with spectrum of symptoms presented and laryngeal morphology. Methods and Methodology  This study was prospective study done on a total of 165 patients who attended the department of otorhinolaryngology, at a tertiary care center in South India with various ENT complaints. Patients who were above 18 years of age from both sexes and gave history of smoking and alcohol consumption were included in this study irrespective of their complaints. All these patients underwent video laryngoscopy, which helped in early diagnosing various laryngeal lesions and screening tool for development of laryngeal lesions. Following diagnosis, patients were treated accordingly with lifestyle modifications and abstinence from smoking and alcohol. The primary outcome measure is screening for laryngeal morphology and secondary outcome measures are identifiable laryngeal benign and malignant lesions among smokers and alcoholics who required appropriate treatment. Results  There was a significant association between the type of lesion and age group, type of lesion and smoking, and type of lesion and alcohol when compared with nonsmokers and non-alcoholics. As the pack years and amount of alcohol consumption increased, there was a significant increase in the severity and association of lesions. Conclusion  We were able to diagnose a large number of laryngeal lesions that helped in the early detection of premalignant and malignant lesions and their early treatment. The patients who were diagnosed with premalignant and malignant changes underwent microlaryngeal excision of the lesion and were in close follow-up to detect any recurrence.
目的和目的本研究的主要目的是通过视频喉镜识别吸烟者和酗酒者喉部的演变、早期变化、癌前病变和恶性病变,并将吸烟和饮酒的持续时间、频率和数量与症状谱和喉部形态联系起来。方法和方法本研究是一项前瞻性研究,共对165名在印度南部一家三级保健中心耳鼻喉科就诊的患者进行了前瞻性研究。年龄在18岁以上、有吸烟和饮酒史的男女患者都包括在这项研究中,无论他们的抱怨是什么。所有患者均行视频喉镜检查,有助于早期诊断各种喉部病变,为喉部病变的发展提供筛查工具。诊断后,患者接受相应的生活方式改变和戒烟戒酒治疗。主要结局指标是喉部形态学筛查,次要结局指标是需要适当治疗的吸烟者和酗酒者中可识别的喉部良性和恶性病变。结果病变类型与年龄组、病变类型与吸烟、病变类型与酒精有显著相关性。随着年龄和饮酒量的增加,病变的严重程度和相关性显著增加。结论我们能够诊断出大量的喉部病变,有助于早期发现癌前病变和恶性病变并进行早期治疗。诊断为癌前病变和恶性病变的患者行喉部小病变切除术,并密切随访以发现任何复发。
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引用次数: 0
期刊
International Journal of Recent Surgical and Medical Sciences
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