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Primary Sclerosing Cholangitis Pruritus Treated with Plasmapheresis 血浆置换治疗原发性硬化性胆管炎瘙痒
Pub Date : 2023-04-04 DOI: 10.1055/s-0043-1761510
Katharine Tippins, Oyewale O. Shiyanbola, W. N. Rose
Abstract Evidence regarding the efficacy of plasmapheresis for pruritus due to hepatobiliary disease is sparse. The mechanism of pruritus in this context is poorly understood. Some candidates for the offending agents are bile salts and histamine. Primary sclerosing cholangitis is one such disease and appears to have an autoimmune component. The rationale for plasmapheresis for patients who are refractory to medical therapy has some plausibility because the nonspecific nature of plasmapheresis may significantly decrease one or more of the offending substances in the patient's plasma. We share our experience of a patient with pruritus due to primary sclerosing cholangitis who benefited from plasmapheresis.
关于血浆置换治疗肝胆疾病所致瘙痒的疗效的证据很少。在这种情况下,瘙痒的机制尚不清楚。一些候选的致病因子是胆盐和组胺。原发性硬化性胆管炎就是这样一种疾病,似乎有自身免疫成分。对药物治疗难治性患者进行血浆置换的理由有一定道理,因为血浆置换的非特异性可能会显著减少患者血浆中的一种或多种有害物质。我们分享我们的经验,患者瘙痒由于原发性硬化性胆管炎谁受益于血浆置换。
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引用次数: 0
Difficult Bronchoscopy and Foreign Body Removal: Our Experience 困难的支气管镜检查和异物清除:我们的经验
Pub Date : 2023-04-04 DOI: 10.1055/s-0043-1764365
P. S., N. Rb, G. K., Karthika Sr, R. S
Abstract Background  Foreign body in the airway is the most life-threatening situation. Most foreign bodies present as acute emergency and can be removed by endoscopy/bronchoscopy, while a few causes complication of a retained foreign body which requires emergency tracheostomy to secure airway followed by foreign body removal. Case Presentation  We report our experience in the management of three children who required tracheostomy through which bronchoscope was introduced and foreign body removed. All patients with unrecognized retained foreign body presented with respiratory distress with desaturation. Imaging was suggestive of atelectasis. After foreign body removal patients recovered well and decannulated by day 5. Subglottis is the narrowest part of pediatric airway. As these foreign bodies were vegetative they are hygroscopic in nature and hence would not be able to remove the foreign body by bronchoscopic guidance. Hence, tracheostomy was done to provide access followed by bronchoscopic removal. Conclusion  Aspirated foreign body present challenges to the ear, nose, and throat surgeon. Newer techniques enable removal of foreign body easier. Tracheostomy combined with bronchoscopy can be a life-saving and easy to perform procedure which involves removal of foreign body at the same time.
摘要背景呼吸道异物是最危及生命的情况。大多数异物是急性急诊,可通过内窥镜/支气管镜清除,而少数异物会引起并发症,需要紧急气管切开术以确保气道安全,然后取出异物。我们报告我们的经验,在处理三个儿童需要气管切开术,通过支气管镜和异物取出。所有未识别的异物残留患者均表现为呼吸窘迫伴去饱和。影像学提示肺不张。异物取出后患者恢复良好,第5天脱管。声门下是小儿气道最狭窄的部分。由于这些异物是植物性的,它们本质上是吸湿的,因此不能通过支气管镜引导去除异物。因此,气管切开术提供通道,然后支气管镜切除。结论吸入性异物是耳鼻喉外科医师面临的挑战。较新的技术使清除异物更容易。气管切开术联合支气管镜检查可以挽救生命,并且易于操作,同时可以清除异物。
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引用次数: 0
Mitochondrial Disease Masquerading as Recurrent Encephalopathy 线粒体疾病伪装成复发性脑病
Pub Date : 2023-04-04 DOI: 10.1055/s-0043-1761616
Rajalaxmi Satapathy, Pragateshnu Das
Abstract A young male who was a diabetic presented with gradually progressive hearing loss, recurrent episodic behavioral abnormality, easy fatigability, proximal weakness, and seizures. The patient was evaluated in detail to find out the etiology of encephalitis. The serum autoimmune encephalitis panel was negative. On magnetic resonance imaging of the Brain, there was temporoparietal T2 and fluid-attenuated inversion recovery hyperintensity. In the magnetic resonance spectroscopy study, a lactate peak was found. So, the patient was evaluated for mitochondrial illness mitochondrial encephalopathy lactic acidosis with stroke-like symptoms) and it was confirmed by a genetic study. This case illustrates that though it is a rare disease, always a strong clinical index of suspicion is required for the diagnosis of mitochondrial disorders in case of multisystem involvement so that diagnosis would not be missed.
摘要一位年轻男性糖尿病患者表现为逐渐进行性听力丧失,反复发作性行为异常,易疲劳,近端无力和癫痫发作。对患者进行了详细的评估,以查明脑炎的病因。血清自身免疫性脑炎检查结果为阴性。脑磁共振成像显示颞顶叶T2和液体衰减反转恢复高信号。在磁共振波谱研究中,发现一个乳酸峰。因此,患者被评估为线粒体疾病(线粒体脑病(有卒中样症状的乳酸性酸中毒),并通过基因研究得到证实。本病例说明,虽然是一种罕见的疾病,但在累及多系统的情况下,对线粒体疾病的诊断总是需要强烈的临床怀疑指标,以免漏诊。
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引用次数: 0
Knotted Stent—Emphasizing the Need of Radiology Assistance in Urology 结扎支架——强调泌尿外科放射辅助的需要
Pub Date : 2023-04-04 DOI: 10.1055/s-0043-1764364
S. P. Dhangar
Abstract Ureteral double-J stents have become a part and parcel in contemporary urologic practice. As the use of stents is increasing, the complications are also increasing. Knot formation in the double-J stent is rare phenomenon. Twenty-seven cases have been reported till now. This case would be the 28th case to be reported, in a young male with solitary left kidney and who was on regular periodic stent substitution.
输尿管双j型支架已成为当代泌尿外科的重要组成部分。随着支架使用的增加,并发症也在增加。双j型支架中结的形成是罕见的现象。截至目前已报告27例。该病例将是第28例报告的病例,在一个年轻的男性与孤立的左肾,谁是定期支架置换。
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引用次数: 0
“Clinicoradiological Score – Valuable Tool to Assess the Risk of Strangulated Small Bowel Obstruction in Tertiary Care Center” “临床放射学评分-评估三级保健中心绞窄性小肠阻塞风险的宝贵工具”
Pub Date : 2023-04-04 DOI: 10.1055/s-0043-1761416
Gunasekaran Monisha, M. S, H. Ranganath
Abstract Background  Small bowel obstruction accounts for about 3% of the emergency laparotomies, hence there is a need for early recognition of the risk associated with strangulated small bowel obstruction. However, there is no single reliable tool for evaluating the bowel strangulation risk precisely and quickly, hence we sought to assess the specificity and sensitivity of a scoring system named “Clinicoradiological score” as a tool to assess the risk of strangulated small bowel obstruction in tertiary care center for early intervention. Methods  The study was an observational study conducted on 50 patients with clinical symptoms of small intestinal obstruction, diagnosed by CT and admitted in-patient basis at the general surgery department in the hospitals attached to Bangalore Medical College and Research Institute, Bengaluru from November 2017 to May 2019. In this scoring system, one point was given to each factor which includes pain duration (4 or more days), guarding, leucocyte count at least 10 ×10 9 /L, C-reactive protein 75 mg/L or more, free fluid at least 500 mL (CT criteria), reduced wall contrast enhancement (CT criteria) leading to a maximum score of 6. Statistics  Based on standard treatment outcome, patients were grouped into three categories (conservative management, laparotomy without resection and anastomosis, and laparotomy with resection and anastomosis). Data was analyzed by descriptive statistics. The risk factors were compared between three patient groups and Chi-square test used for hypothesis testing. Sensitivity and specificity were evaluated for accuracy of score. Results  Out of the six factors of Clinicoradiological score, five factors were found to be predictors ( p -value <0.01), while history of pain more than 3 days did not have a significant p -value. In our study all 18 patients with score more than 3 had gangrenous changes and underwent resection. The p -value of the score was found to be significant. Conclusion  Clinicoradiological score has been proved to be a valuable tool in predicting the risk of strangulated small bowel obstruction and ascertained the need for subsequent intestinal resection.
背景小肠梗阻约占急诊剖腹手术的3%,因此需要早期认识绞窄性小肠梗阻的相关风险。然而,目前还没有一种可靠的工具可以准确、快速地评估肠绞窄风险,因此,我们试图评估一种名为“临床放射学评分”的评分系统的特异性和敏感性,作为评估三级保健中心绞窄性小肠梗阻风险的工具,以进行早期干预。方法对2017年11月至2019年5月在班加罗尔医学院附属医院普通外科住院的50例经CT诊断有小肠梗阻临床症状的患者进行观察性研究。在这个评分系统中,每个因素都给1分,包括疼痛持续时间(4天或更长)、保护、白细胞计数至少10 ×10 9 /L、c反应蛋白75 mg/L或更多、游离液至少500 mL (CT标准)、壁增强减弱(CT标准),最高得分为6分。根据标准治疗结果,将患者分为保守治疗、开腹不切除吻合、开腹切除吻合3组。数据采用描述性统计进行分析。比较三组患者的危险因素,采用卡方检验进行假设检验。对评分的准确性进行敏感性和特异性评估。结果在临床放射学评分的6个因素中,有5个因素是预测因子(p值<0.01),而疼痛史大于3 d无显著p值。在我们的研究中,所有18例评分超过3分的患者都发生了坏疽性改变并进行了切除。发现得分的p值具有显著性。结论临床放射学评分是预测绞窄性小肠梗阻风险和确定后续肠切除术必要性的重要工具。
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引用次数: 1
Clinical and Radiological Results of Minimally Invasive Two-Hole Dynamic Hip Screw Fixation of Stable Intertrochanteric Fractures: A Prospective Study of 50 Patients 微创双孔动力髋螺钉固定稳定转子间骨折的临床和影像学结果:一项50例患者的前瞻性研究
Pub Date : 2023-04-04 DOI: 10.1055/s-0043-1761618
F. A. Dar, Zaffar Iqbal, A. H. Lone, N. Ali
Abstract Background  Intertrochanteric fractures are fractures of elderly population and are known for morbidity and mortality. Early stabilization with minimal surgical trauma is important for early mobilization to prevent recumbence-related complications. Methods  This prospective study was conducted on 50 stable intertrochanteric fractures that were managed by fixation with a small two-hole dynamic hip screw –(DHS) side plate using a minimally invasive technique. The surgical time, intraoperative blood loss, length of the skin incision, duration of hospital stay, time to full weight bearing and fracture union, and complications were recorded. Results  The mean age of the patients was 60.2 years with 64% belonging to male sex. The mean operative time, average blood loss, and mean incision length were 35.6 minutes, 68.4 mL, and 3.7 cm, respectively. Time to bone healing ranged from 10 to 16 weeks (mean 13 weeks). Two patients had hip screw backout but that did not interfere with failure of fixation. Conclusion  Stabilization of stable intertrochanteric fractures with two-hole DHS using minimally invasive approach is a viable option with negligible complication rate related to failure of small DHS side plate.
摘要背景:股骨粗隆间骨折是老年人骨折,发病率和死亡率高。早期稳定与最小的手术创伤是重要的早期活动,以防止仰卧相关的并发症。方法对50例稳定的股骨粗隆间骨折进行前瞻性研究,这些骨折均采用微创技术用小的双孔动态髋螺钉-侧板固定。记录手术时间、术中出血量、皮肤切口长度、住院时间、完全负重时间、骨折愈合时间及并发症。结果患者平均年龄60.2岁,男性占64%。平均手术时间35.6分钟,平均出血量68.4 mL,平均切口长度3.7 cm。骨愈合时间为10 ~ 16周(平均13周)。2例患者髋螺钉退出,但不影响固定失败。结论微创入路固定稳定型转子间骨折是一种可行的方法,且小DHS侧板失效并发症发生率可忽略不计。
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引用次数: 0
A Case of Primary EAC Cholesteatoma Extending into Antrum with Normal Middle Ear 原发性EAC胆脂瘤延伸至正常中耳鼻窦1例
Pub Date : 2023-04-04 DOI: 10.1055/s-0043-1761458
S. Shrivastava, Rishita Kalra, Somyagupta Somyagupta, V. Pathak, P. Nayak, Stuti Shukla
Abstract Introduction  A cholesteatoma is a three-dimensional sac lined by keratinized squamous epithelium containing desquamated keratinized epithelial cell which secretes enzymes that have the tendency to expand and erode the bony structure underlying it and cause intracranial and extracranial complications. This cystic mass is in an abnormal location such as the middle ear, the petrous apex, or the external auditory canal (EAC). It is mostly found in the middle ear and rarely in the EAC. Here we have reported a rare case of unilateral primary EAC cholesteatoma with mild hearing loss in a middle-aged male. Case Report  We have reported a case of a 34-year-old male with complaints of right-sided ear discharge and right-sided decreased hearing for the last 5 to 6 years. On examination, right ear EAC was found to be dry, and a sac was observed in posterior wall extending to mastoid present with clear attic, and intact retracted tympanic membrane that was then followed by radiological evaluation to establish the diagnosis of EAC cholesteatoma. This was surgically treated and ear was cleared of all disease. Patient's symptoms improved postoperatively. Conclusion  Primary EAC cholesteatoma with disease-free middle ear is a rare finding and there is very less definitive literature available on the pathogenesis of the same.
胆脂瘤是一种由角质化的鳞状上皮内衬的三维囊,其中含有脱皮的角质化上皮细胞,其分泌的酶具有扩张和侵蚀其底层骨结构的倾向,并引起颅内和颅外并发症。囊性肿块位于异常位置,如中耳、岩尖或外耳道。它主要发生在中耳,很少发生在EAC。我们在此报告一例罕见的单侧原发性EAC胆脂瘤合并轻度听力损失的中年男性病例。病例报告我们报告了一例34岁男性,在过去的5至6年里,他的主诉是右耳分泌物和右侧听力下降。检查发现右耳EAC干燥,后壁可见囊囊延伸至乳突,有清晰的上盖,鼓膜完整缩回,影像学检查确定EAC胆脂瘤的诊断。手术治疗后,所有的疾病都被清除了。患者术后症状好转。结论原发性EAC胆脂瘤合并无病中耳是一种罕见的发现,其发病机制的明确文献很少。
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引用次数: 0
Atraumatic Isolated Bilateral Fibular Shaft Fragility Fracture: A Rare Case 非外伤性孤立性双侧腓骨干脆性骨折一例
Pub Date : 2023-04-04 DOI: 10.1055/s-0043-1764363
Suryakanth Kalluraya, AA Hosangadi, Prabhu P. Munavalli, Akash Kumar
Abstract Fragility fractures, a form of stress fracture brought on by physiological stress on weak bones, are not common. It might be challenging to diagnose a fragility fracture since a standard radiograph shows signs of fracture repair rather than the actual fracture. We present a case of a 32-year-old woman who has been complaining of both leg pain for the last 4 months and has been unable to stand for the last 1 week. Further analysis revealed that her vitamin D levels were insufficient.
摘要脆性骨折是一种由生理应力对弱骨造成的应力性骨折,并不常见。诊断脆性骨折可能具有挑战性,因为标准的x线片显示的是骨折修复的迹象,而不是实际的骨折。我们报告一个32岁的女性病例,她在过去的4个月里一直抱怨双腿疼痛,并且在过去的1周内无法站立。进一步的分析显示,她的维生素D水平不足。
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引用次数: 0
Prospective Comparative Short-Term Study of Autologous Leucocyte-Rich Platelet-Rich Plasma vs. Local Steroids in Chronic Plantar Fascitis 自体富白细胞富血小板血浆与局部类固醇治疗慢性足底筋膜炎的前瞻性短期比较研究
Pub Date : 2023-04-04 DOI: 10.1055/s-0043-1761456
Nilesh S. Sakharkar, P. Tathe, Prateek Jain, Aniket N. Adewar, Santosh Pol
Abstract Background  Plantar fasciitis is the most common cause of heel pain and is difficult to treat in most chronic and severe forms. Management of plantar fasciitis includes non-surgical options such as non-steroidal anti-inflammatory drugs and corticosteroids, physical therapy, orthotics, and surgical management includes plantar fasciotomy. Local injection of platelet-rich plasma as well as local steroids is an emerging concept in treating recalcitrant tendon and ligament pathology, including plantar fasciitis. Objectives  The aim of the study was to evaluate and compare the outcome of patients treated with a single injection of autologous leucocyte-rich platelet-rich plasma with single-injection local steroids triamcinolone in chronic plantar fasciitis. Methodology  The study was conducted for a duration of 24 months. In total, 60 patients with clinically diagnosed chronic plantar fasciitis were selected for study and divided in two groups using the single allocation randomization method as those treated with autologous injection leucocyte-rich platelet-rich plasma and those with injection local steroid triamcinolone and prospectively followed and compared. Results  Both groups were evaluated subjectively and functionally at primary visit and then on follow-up at 2 weeks, 4 weeks, 8 weeks, and 12 weeks by VAS and hind foot AOFAS score. Conclusion  We concluded that both injection platelet-rich plasma-treated and injection local steroid-treated patients provide symptomatic relief in the treatment of chronic plantar fasciitis both subjectively and functionally. The steroid treated group showed early symptomatic improvement at 2 weeks, and results at 12 weeks to further follow-up were suggestive that single-injection leucocyte-rich platelet-rich plasma provided better functional results.
摘要背景足底筋膜炎是引起足跟疼痛最常见的原因,并且在大多数慢性和严重的形式中难以治疗。足底筋膜炎的治疗包括非手术治疗,如非甾体类抗炎药和皮质类固醇、物理治疗、矫形术和手术治疗,包括足底筋膜切开术。局部注射富血小板血浆和局部类固醇是治疗顽固性肌腱和韧带病理(包括足底筋膜炎)的新兴概念。目的:评价和比较单次注射自体富白细胞富血小板血浆和单次注射局部类固醇曲安奈德治疗慢性足底筋膜炎的疗效。方法本研究为期24个月。选择60例临床诊断为慢性足底筋膜炎的患者进行研究,采用单分配随机法分为自体注射富白细胞富血小板血浆组和局部注射类固醇曲安奈德两组,进行前瞻性随访比较。结果两组在初次就诊时及随访2周、4周、8周、12周时分别采用VAS评分和后足AOFAS评分进行主观和功能评价。结论富血小板血浆注射治疗和局部类固醇注射治疗均能在主观上和功能上缓解慢性足底筋膜炎的症状。类固醇治疗组在2周时出现早期症状改善,进一步随访12周时的结果提示单次注射富白细胞富血小板血浆可提供更好的功能效果。
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引用次数: 0
Incidentally Detected Meckel Diverticulum during Cystectomy: An Unhinging Dilemma? 膀胱切除术中偶然发现的梅克尔憩室:一个令人费解的困境?
Pub Date : 2023-04-04 DOI: 10.1055/s-0043-1761468
Manjeet Kumar
Meckel ’ s diverticulum isfound in2% of the population, which makes it the commonest congenital abnormality of the gastrointestinal tract. It is diagnosed as an incidental fi nding during surgery for other reasons. It is found 100cm from the ileocecal junction, at the antimesenteric border. Other pre-sentations can be abdominal pain, infection, bleeding from ectopic mucosa, recurrent intestinal obstruction
梅克尔憩室在2%的人群中被发现,这使得它成为最常见的胃肠道先天性异常。由于其他原因,它被诊断为手术中偶然发现的。在离回盲交界处100厘米处的反肠边界处发现。其他表现为腹痛、感染、异位粘膜出血、反复肠梗阻
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引用次数: 0
期刊
International Journal of Recent Surgical and Medical Sciences
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