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Prognostic Value of Consolidation in Lung Tomography in Patients With Acute Respiratory Distress Syndrome 肺断层扫描对急性呼吸窘迫综合征患者合并症的预后价值
Q4 Medicine Pub Date : 2024-10-01 DOI: 10.1016/j.opresp.2024.100366
Santa Cruz Roberto , Domeniconi Gustavo , Favot Carolina , Pagano Fernando , Choi Marcelo
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引用次数: 0
Flecainide-associated Pneumonitis, a Case Report: COVID is Not All That it Seems 弗莱凯尼德相关性肺炎,病例报告:COVID 并非看上去那么简单
Q4 Medicine Pub Date : 2024-10-01 DOI: 10.1016/j.opresp.2024.100372
Diego Ferrer-Pargada , David Iturbe , Sandra Tello , Sheila Izquierdo , Elena Peña , Cristina Castrillo Bustamante , Javier Gómez-Roman
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引用次数: 0
Organizing Pneumonia Associated With Subclinical HSV Extrapulmonary Infection in an Immunocompetent Host: A Case Report 免疫功能正常宿主亚临床 HSV 肺外感染引发的组织性肺炎:病例报告
Q4 Medicine Pub Date : 2024-10-01 DOI: 10.1016/j.opresp.2024.100367
Anna Michela Gaeta , Anna Annunziata , Giuseppe Fiorentino
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引用次数: 0
Pulmonary Embolism: Is AI One of the Team? 肺栓塞:人工智能是团队中的一员吗?
Q4 Medicine Pub Date : 2024-10-01 DOI: 10.1016/j.opresp.2024.100371
Sara Lojo-Lendoiro , Ignacio Díaz-Lorenzo , Jose Andrés Guirola Ortíz , Fernando Gómez Muñoz
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引用次数: 0
Personalized Medicine in Severe Asthma: Bridging the Gaps 重症哮喘的个性化医疗:缩小差距
Q4 Medicine Pub Date : 2024-10-01 DOI: 10.1016/j.opresp.2024.100368
Juan Luis García-Rivero , Ismael García-Moguel
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引用次数: 0
COPD Exacerbation by SARS-CoV-2. A Cause of Future Poor Disease Control? SARS-CoV-2导致慢性阻塞性肺病恶化。未来疾病控制不力的原因?
Q4 Medicine Pub Date : 2024-10-01 DOI: 10.1016/j.opresp.2024.100369
Juan Marco Figueira-Gonçalves , Rafael Golpe
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引用次数: 0
Older Patients With Interstitial Lung Disease Feature a Distinct Clinical Profile 老年间质性肺病患者具有独特的临床特征。
Q4 Medicine Pub Date : 2024-10-01 DOI: 10.1016/j.opresp.2024.100374
Laura Feltrer-Martínez , Sandra Orozco , Ana Alonso , Paloma Millan-Billi , Silvia Barril , Gisela Ruibal , Joel Francesqui , David Lobo-Prat , Ana Gimenez , Laura Lopez , Laura Martinez-Martinez , Ivan Castellvi , Diego Castillo

Introduction

There are few studies investigating the clinical profile of older patients with interstitial lung disease (ILD), so this study investigated the characteristics of the older population diagnosed with ILD.

Material and methods

Retrospective study in a population of new referrals at an ILD clinic from January 2013 to September 2017. Patients over 64 years were selected. Data collection included diseases variables, diagnostic procedures and comorbidities. Gender-age-physiology (GAP) stage, composite physiologic index (CPI) and Charlson index was calculated. Statistical analysis was performed to investigate risk factors associated with survival.

Results

A total of 232 patients were included in this study. Mean age was 76.3 years (SD 6.5). As per protocol, 69.3% completed the initial assessment but this was lower in the elderly group (61.5%). The most frequent diagnosis was unclassifiable ILD (24.1%), followed by ILD associated with connective tissue disease (21.6%), IPF (12.1%) and hypersensitivity pneumonitis (10.3%). During follow-up (36.7 months (SD 28.6)) a significant proportion of patients died (55 cases, 23.7% of the cohort), especially in the late older group (30.4%). Kaplan–Meier curves showed that those over 75 years have a worse survival even when adjusted by covariables (p < 0.001). CPI was the only score with statistical significance in a multivariate analysis (HR 1.06. p 0.006).

Conclusions

Older adults with ILD featured a distinct clinical profile. Our findings highlight the need to develop non-invasive biomarkers and specific scores adapted to this age-group.
导论:关于老年间质性肺疾病(ILD)患者临床特征的研究很少,因此本研究探讨了老年间质性肺疾病患者的特征。材料和方法:对2013年1月至2017年9月间一家ILD诊所的新转诊人群进行回顾性研究。选择年龄超过64岁的患者。数据收集包括疾病变量、诊断程序和合并症。计算性别-年龄-生理(GAP)分期、综合生理指数(CPI)和Charlson指数。统计分析与生存相关的危险因素。结果:本研究共纳入232例患者。平均年龄76.3岁(SD 6.5)。根据方案,69.3%的患者完成了初步评估,但这一比例在老年组中较低(61.5%)。最常见的诊断是无法分类的ILD(24.1%),其次是与结缔组织病相关的ILD (21.6%), IPF(12.1%)和超敏性肺炎(10.3%)。在随访期间(36.7个月(SD 28.6)),有相当比例的患者死亡(55例,占队列的23.7%),特别是在老年晚期组(30.4%)。Kaplan-Meier曲线显示,即使经协变量调整,75岁以上患者的生存率也较低(p < 0.006)。结论:老年ILD患者具有独特的临床特征。我们的研究结果强调了开发适合该年龄组的非侵入性生物标志物和特定评分的必要性。
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引用次数: 0
Innovación en sueño
Q4 Medicine Pub Date : 2024-10-01 DOI: 10.1016/j.opresp.2025.100402
Laura Vigil, Toni Zapata, Andrea Grau, Marta Bonet, Montserrat Montaña, María Piñar
Advances in sleep medicine have driven significant improvements in the diagnosis and treatment of sleep disorders such as obstructive sleep apnea (OSA). This disorder affects one billion people worldwide and traditionally, diagnosis is based on polysomnography (PSG), a laborious method that requires specialized personnel. However, the integration of artificial intelligence (AI) in sleep medicine has made it possible to automate the analysis of sleep phases and respiratory events with high accuracy.
Machine learning algorithms and neural networks have proven to be effective in automatic sleep coding, with hit rates comparable to those of human experts. These advances make it possible to improve the efficiency of sleep labs and to personalize OSA treatment. In addition, techniques such as cluster analysis are used to identify symptomatic patterns and phenotypes, which improves understanding of OSA pathophysiology and optimizes CPAP treatment.
However, implementation of AI in hospitals faces technological, ethical, and legal barriers. Challenges include data quality, patient privacy, and the need for specialized personnel. Despite these obstacles, AI and Big Data have the potential to transform medical care for sleep disorders, improving both diagnosis and treatment adherence, provided regulatory and cultural barriers are overcome.
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引用次数: 0
Gemelos digitales pulmonares
Q4 Medicine Pub Date : 2024-10-01 DOI: 10.1016/j.opresp.2024.100394
Ana Fernández-Tena , Carlos Arnedo , Guillaume Houzeaux , Beatriz Eguzkitza
The development of lung digital twins (DTs) represents a significant advance in personalized medicine, providing a virtual framework that replicates the structure, function, and pathology of the respiratory system in an individualized manner. DTs integrate clinical data, high-resolution images, and mathematical models to simulate respiratory mechanics, gas diffusion, and fluid dynamics in real time. This technology improves diagnosis, treatment planning, and disease progression monitoring. One of the key applications of lung DTs is the ability to simulate patient-specific response to treatments and predict outcomes, allowing for personalized therapies. Despite advances, the implementation of DTs in clinical practice faces challenges related to data integration, computational efficiency, and ethical considerations regarding data privacy. Nevertheless, lung DTs offer clear promise for improving precision medicine, optimizing patient care, and improving clinical outcomes.
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引用次数: 0
Innovative Use of 3D Reconstruction Models of the Pulmonary Artery for Preoperative Planning 肺动脉三维重建模型在术前规划中的创新应用
Q4 Medicine Pub Date : 2024-10-01 DOI: 10.1016/j.opresp.2024.100380
Andres Obeso , Numan Balci , Yusuf Bayrak , Usman Ahmad
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引用次数: 0
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Open Respiratory Archives
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