Pub Date : 2025-11-04DOI: 10.1016/j.opresp.2025.100510
Lucía Ortega Ruiz , Juan Margallo Iribarnegaray , Begoña Peña del Cura , Clara Seghers Carreras , Ana Belén Enguita Valls , Alicia De Pablo Gafas , Rodrigo Alonso Moralejo , María Teresa Tejedor Ortiz , Carlos Andrés Quezada Loaiza
{"title":"An Unusual Cause of Pulmonary Nodules","authors":"Lucía Ortega Ruiz , Juan Margallo Iribarnegaray , Begoña Peña del Cura , Clara Seghers Carreras , Ana Belén Enguita Valls , Alicia De Pablo Gafas , Rodrigo Alonso Moralejo , María Teresa Tejedor Ortiz , Carlos Andrés Quezada Loaiza","doi":"10.1016/j.opresp.2025.100510","DOIUrl":"10.1016/j.opresp.2025.100510","url":null,"abstract":"","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"8 1","pages":"Article 100510"},"PeriodicalIF":0.0,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145790202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-04DOI: 10.1016/j.opresp.2025.100512
Daniel Carrillos Seguí , Joan B. Soriano
{"title":"Case-finding of COPD and AI","authors":"Daniel Carrillos Seguí , Joan B. Soriano","doi":"10.1016/j.opresp.2025.100512","DOIUrl":"10.1016/j.opresp.2025.100512","url":null,"abstract":"","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"8 1","pages":"Article 100512"},"PeriodicalIF":0.0,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145568916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-27DOI: 10.1016/j.opresp.2025.100509
Juan Luís García-Rivero , Rocío García-García , Alicia Padilla Galo , Astrid Crespo-Lessmann , Marina Blanco-Aparicio , Juan Ignacio Aguiló-Anento , José Ángel Carretero-Gracia
Asthma is a disease that, due to its increasing prevalence and wide-ranging impact, continues to be studied in order to better understand its underlying mechanisms and thus improve both its management and the quality of life of those who suffer from it.
In the context of developing a document of recommendations based on expert opinion following the RAND/UCLA methodology through a Delphi survey on infection and asthma, this non-systematic review of the literature delves into the complex interactions between microorganisms and asthma, providing a comprehensive view, in question and answer mode, on six major aspects relating infection and asthma: 1) the possible infectious origin of asthma, with reference to the respiratory microbiota and the influence of certain respiratory viruses, 2) the role that certain immunodeficiencies may play in the development of bronchial hyperresponsiveness and bronchial infections, 3) the bidirectional association between bronchiectasis and asthma and its identification as a distinguishable phenotype, 4) the importance of the hypersecretory phenotype and infectious exacerbations in the control of asthma and in the assessment of the response to biological treatments, 5) the usefulness of infection prevention and treatment strategies to control asthma, and 6) the curious association between tuberculous infection and disease and the development of atopy and asthma.
{"title":"Infección y asma","authors":"Juan Luís García-Rivero , Rocío García-García , Alicia Padilla Galo , Astrid Crespo-Lessmann , Marina Blanco-Aparicio , Juan Ignacio Aguiló-Anento , José Ángel Carretero-Gracia","doi":"10.1016/j.opresp.2025.100509","DOIUrl":"10.1016/j.opresp.2025.100509","url":null,"abstract":"<div><div>Asthma is a disease that, due to its increasing prevalence and wide-ranging impact, continues to be studied in order to better understand its underlying mechanisms and thus improve both its management and the quality of life of those who suffer from it.</div><div>In the context of developing a document of recommendations based on expert opinion following the RAND/UCLA methodology through a Delphi survey on infection and asthma, this non-systematic review of the literature delves into the complex interactions between microorganisms and asthma, providing a comprehensive view, in question and answer mode, on six major aspects relating infection and asthma: 1) the possible infectious origin of asthma, with reference to the respiratory microbiota and the influence of certain respiratory viruses, 2) the role that certain immunodeficiencies may play in the development of bronchial hyperresponsiveness and bronchial infections, 3) the bidirectional association between bronchiectasis and asthma and its identification as a distinguishable phenotype, 4) the importance of the hypersecretory phenotype and infectious exacerbations in the control of asthma and in the assessment of the response to biological treatments, 5) the usefulness of infection prevention and treatment strategies to control asthma, and 6) the curious association between tuberculous infection and disease and the development of atopy and asthma.</div></div>","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"8 1","pages":"Article 100509"},"PeriodicalIF":0.0,"publicationDate":"2025-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145568917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Antibiotic-resistant respiratory infections necessitate alternative or adjunctive therapeutic strategies to reduce the bacterial burden in patients, particularly in the context of hospital-acquired infections. Bacteriophage therapy has emerged as a promising tool, with a resurgence of research in Western countries for various infectious diseases. The application of phage therapy against pulmonary infections has been primarily investigated for pathogens such as Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter baumannii in in vivo experiments and for Mycobacterium abscessus and P. aeruginosa in compassionate use cases. This review summarizes recent work on phage therapy targeting clinically relevant drug-resistant bacteria that cause nosocomial pulmonary infections, encompassing animal research, clinical cases, and clinical trials.
{"title":"Phage Therapy for Hospital-Acquired Respiratory Bacterial Infections: A Review","authors":"Maria-Carmen Muñoz-Egea , Alianet Rodríguez , Jaime Esteban , Meritxell García-Quintanilla","doi":"10.1016/j.opresp.2025.100507","DOIUrl":"10.1016/j.opresp.2025.100507","url":null,"abstract":"<div><div>Antibiotic-resistant respiratory infections necessitate alternative or adjunctive therapeutic strategies to reduce the bacterial burden in patients, particularly in the context of hospital-acquired infections. Bacteriophage therapy has emerged as a promising tool, with a resurgence of research in Western countries for various infectious diseases. The application of phage therapy against pulmonary infections has been primarily investigated for pathogens such as <em>Pseudomonas aeruginosa</em>, <em>Klebsiella pneumoniae</em>, and <em>Acinetobacter baumannii</em> in in vivo experiments and for <em>Mycobacterium abscessus</em> and <em>P. aeruginosa</em> in compassionate use cases. This review summarizes recent work on phage therapy targeting clinically relevant drug-resistant bacteria that cause nosocomial pulmonary infections, encompassing animal research, clinical cases, and clinical trials.</div></div>","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"8 1","pages":"Article 100507"},"PeriodicalIF":0.0,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145520286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-24DOI: 10.1016/j.opresp.2025.100508
Jorge Mora Pinilla , Fernando García Prieto , Diego Durán Barata , María Teresa Río Ramírez
{"title":"Giant Bronchoesophageal Fistula in Advanced Lung Cancer: A Case Report","authors":"Jorge Mora Pinilla , Fernando García Prieto , Diego Durán Barata , María Teresa Río Ramírez","doi":"10.1016/j.opresp.2025.100508","DOIUrl":"10.1016/j.opresp.2025.100508","url":null,"abstract":"","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"8 1","pages":"Article 100508"},"PeriodicalIF":0.0,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145568920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-16DOI: 10.1016/j.opresp.2025.100506
Eva Cabrera-Cesar , Javier López Garcia , Ivan Perez de Pedro
Pulmonary amyloidosis is an uncommon condition that can mimic interstitial lung diseases (ILDs), leading to diagnostic delays. We describe two cases of diffuse alveoloseptal amyloidosis initially misdiagnosed as ILD. The first involved a 47-year-old woman with systemic AL amyloidosis, successfully treated with CyBorD (Cyclophosphamide, Bortezomib, Dexamethasone) and autologous stem cell transplantation. The second case was a 72-year-old man with localized pulmonary amyloidosis, managed empirically with azathioprine and prednisone, showing slow progression but clinical stability. Histological confirmation using Congo red staining and immunohistochemistry was essential for diagnosis, and systemic disease was excluded through a comprehensive workup. These cases highlight the importance of considering pulmonary amyloidosis in the differential diagnosis of ILDs, especially in patients with unexplained interstitial patterns and monoclonal gammopathy. A multidisciplinary approach is crucial to avoid inappropriate treatment and ensure timely management.
{"title":"Pulmonary Amyloidosis as a Differential Diagnosis in Interstitial Lung Diseases","authors":"Eva Cabrera-Cesar , Javier López Garcia , Ivan Perez de Pedro","doi":"10.1016/j.opresp.2025.100506","DOIUrl":"10.1016/j.opresp.2025.100506","url":null,"abstract":"<div><div>Pulmonary amyloidosis is an uncommon condition that can mimic interstitial lung diseases (ILDs), leading to diagnostic delays. We describe two cases of diffuse alveoloseptal amyloidosis initially misdiagnosed as ILD. The first involved a 47-year-old woman with systemic AL amyloidosis, successfully treated with CyBorD (Cyclophosphamide, Bortezomib, Dexamethasone) and autologous stem cell transplantation. The second case was a 72-year-old man with localized pulmonary amyloidosis, managed empirically with azathioprine and prednisone, showing slow progression but clinical stability. Histological confirmation using Congo red staining and immunohistochemistry was essential for diagnosis, and systemic disease was excluded through a comprehensive workup. These cases highlight the importance of considering pulmonary amyloidosis in the differential diagnosis of ILDs, especially in patients with unexplained interstitial patterns and monoclonal gammopathy. A multidisciplinary approach is crucial to avoid inappropriate treatment and ensure timely management.</div></div>","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"8 1","pages":"Article 100506"},"PeriodicalIF":0.0,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145520285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Modifiable factors such as obesity, vitamin D deficiency, and eosinophilia may contribute to increased asthma severity, but their combined impact remains underexplored, especially in resource-limited settings. This study aimed to investigate the independent and combined associations of obesity, vitamin D deficiency, and eosinophilia with asthma severity in children aged 6–18 years in Arak, Iran.
Material and methods
In this cross-sectional study, 177 children with physician-diagnosed asthma were recruited from the Amir-Kabir Hospital in 2024. Data on body mass index, serum 25-hydroxy vitamin D levels, and eosinophil counts were collected. Asthma severity was categorized as mild, moderate, or severe according to clinical guidelines. Statistical analyses included chi-square tests, ANOVA, and multivariate logistic regression adjusting for age, sex, and family history.
Results
The mean age of participants was 10.4 ± 3.1 years, and 69.5% were male. Overweight/obesity was observed in 30.5%, vitamin D deficiency in 56.5%, and eosinophilia in 10.2% of the children. Asthma severity was mild in 74.6%, moderate in 15.3%, and severe in 10.2% of cases. All three risk factors were significantly more prevalent in children with moderate–severe asthma (p < 0.001). Multivariate analysis revealed that overweight/obesity (adjusted overall risk (OR): 3.21; 95% confidence interval (95% CI): 1.87–5.51), vitamin D deficiency (adjusted OR: 2.76; 95% CI: 1.45–5.25), and eosinophilia (adjusted OR: 8.42; 95% CI: 3.24–21.89) were independently associated with increased asthma severity.
Conclusion
Obesity, vitamin D deficiency, and eosinophilia are independently associated with greater asthma severity in children. Addressing these risk factors through integrated clinical assessments and public health interventions may improve asthma outcomes.
{"title":"Investigating the Role of Obesity, Vitamin D Deficiency, and Eosinophilia in Pediatric Asthma Severity: A Cross-sectional Study","authors":"Mobina Rabiei , Maryam Mohammadi , Saeed Amini , Javad Nazari","doi":"10.1016/j.opresp.2025.100505","DOIUrl":"10.1016/j.opresp.2025.100505","url":null,"abstract":"<div><h3>Introduction</h3><div>Modifiable factors such as obesity, vitamin D deficiency, and eosinophilia may contribute to increased asthma severity, but their combined impact remains underexplored, especially in resource-limited settings. This study aimed to investigate the independent and combined associations of obesity, vitamin D deficiency, and eosinophilia with asthma severity in children aged 6–18 years in Arak, Iran.</div></div><div><h3>Material and methods</h3><div>In this cross-sectional study, 177 children with physician-diagnosed asthma were recruited from the Amir-Kabir Hospital in 2024. Data on body mass index, serum 25-hydroxy vitamin D levels, and eosinophil counts were collected. Asthma severity was categorized as mild, moderate, or severe according to clinical guidelines. Statistical analyses included chi-square tests, ANOVA, and multivariate logistic regression adjusting for age, sex, and family history.</div></div><div><h3>Results</h3><div>The mean age of participants was 10.4<!--> <!-->±<!--> <!-->3.1 years, and 69.5% were male. Overweight/obesity was observed in 30.5%, vitamin D deficiency in 56.5%, and eosinophilia in 10.2% of the children. Asthma severity was mild in 74.6%, moderate in 15.3%, and severe in 10.2% of cases. All three risk factors were significantly more prevalent in children with moderate–severe asthma (<em>p</em> <!--><<!--> <!-->0.001). Multivariate analysis revealed that overweight/obesity (adjusted overall risk (OR): 3.21; 95% confidence interval (95% CI): 1.87–5.51), vitamin D deficiency (adjusted OR: 2.76; 95% CI: 1.45–5.25), and eosinophilia (adjusted OR: 8.42; 95% CI: 3.24–21.89) were independently associated with increased asthma severity.</div></div><div><h3>Conclusion</h3><div>Obesity, vitamin D deficiency, and eosinophilia are independently associated with greater asthma severity in children. Addressing these risk factors through integrated clinical assessments and public health interventions may improve asthma outcomes.</div></div>","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"8 1","pages":"Article 100505"},"PeriodicalIF":0.0,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145468260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-09DOI: 10.1016/j.opresp.2025.100501
David Peña-Otero , Andrés Tenes , María Dolores Martínez Pitarch , Teresa García-Barredo Restegui , Esperanza Salcedo Lobera , Marta Bascuas Arribas , Carmen Fernández-Arias , Ester Zamarrón de Lucas , Miguel Ángel Sánchez de Toro
The 58th SEPAR Congress, held in Bilbao, June 2025, consolidated its position as a scientific benchmark and forum for interdisciplinary dialogue for the international respiratory community. New clinical guidelines, advances in respiratory care, cutting-edge technologies, e-health, accessibility to artificial intelligence applied to early diagnosis and telemonitoring, the ecosystemic approach, and equity applied to respiratory diseases were critically and constructively addressed.
Under the same theme, “Breathing Together”,’ the 8th SEPAR Patient Forum was held simultaneously, with active participation from the public, providing a transdisciplinary perspective and enabling their integration into healthcare management.
This article summarizes the most relevant aspects presented in 9 areas, in alphabetical order: asthma; pulmonary circulation; chronic obstructive pulmonary disease; respiratory nursing; respiratory physiotherapy; interventional pulmonology, lung function, and transplantation; pediatric pulmonology; thoracic oncology; tuberculosis, and respiratory infections.
{"title":"Highlights del 58.° Congreso de la Sociedad Española de Neumología y Cirugía Torácica (SEPAR)","authors":"David Peña-Otero , Andrés Tenes , María Dolores Martínez Pitarch , Teresa García-Barredo Restegui , Esperanza Salcedo Lobera , Marta Bascuas Arribas , Carmen Fernández-Arias , Ester Zamarrón de Lucas , Miguel Ángel Sánchez de Toro","doi":"10.1016/j.opresp.2025.100501","DOIUrl":"10.1016/j.opresp.2025.100501","url":null,"abstract":"<div><div>The 58<sup>th</sup> SEPAR Congress, held in Bilbao, June 2025, consolidated its position as a scientific benchmark and forum for interdisciplinary dialogue for the international respiratory community. New clinical guidelines, advances in respiratory care, cutting-edge technologies, e-health, accessibility to artificial intelligence applied to early diagnosis and telemonitoring, the ecosystemic approach, and equity applied to respiratory diseases were critically and constructively addressed.</div><div>Under the same theme, “Breathing Together”,’ the 8th SEPAR Patient Forum was held simultaneously, with active participation from the public, providing a transdisciplinary perspective and enabling their integration into healthcare management.</div><div>This article summarizes the most relevant aspects presented in 9<!--> <!-->areas, in alphabetical order: asthma; pulmonary circulation; chronic obstructive pulmonary disease; respiratory nursing; respiratory physiotherapy; interventional pulmonology, lung function, and transplantation; pediatric pulmonology; thoracic oncology; tuberculosis, and respiratory infections.</div></div>","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"8 1","pages":"Article 100501"},"PeriodicalIF":0.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145419591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}