Open Respiratory Archives最新文献

英文中文

An Unusual Cause of Pulmonary Nodules 肺结节的一种罕见病因

Q4 Medicine

Open Respiratory Archives

Pub Date : 2025-11-04 DOI: 10.1016/j.opresp.2025.100510

Lucía Ortega Ruiz , Juan Margallo Iribarnegaray , Begoña Peña del Cura , Clara Seghers Carreras , Ana Belén Enguita Valls , Alicia De Pablo Gafas , Rodrigo Alonso Moralejo , María Teresa Tejedor Ortiz , Carlos Andrés Quezada Loaiza

引用次数: 0

Pulmonary Alveolar Microlithiasis: Revisiting the First Lung Transplant Experience 肺泡微石症：回顾第一次肺移植的经验

Q4 Medicine

Open Respiratory Archives

Pub Date : 2025-11-04 DOI: 10.1016/j.opresp.2025.100515

Khaled Ebrahim Al Ebrahim

引用次数: 0

Case-finding of COPD and AI 慢性阻塞性肺病和人工智能的病例发现

Q4 Medicine

Open Respiratory Archives

Pub Date : 2025-11-04 DOI: 10.1016/j.opresp.2025.100512

Daniel Carrillos Seguí , Joan B. Soriano

引用次数: 0

Infección y asma 感染和哮喘

Q4 Medicine

Open Respiratory Archives

Pub Date : 2025-10-27 DOI: 10.1016/j.opresp.2025.100509

Juan Luís García-Rivero , Rocío García-García , Alicia Padilla Galo , Astrid Crespo-Lessmann , Marina Blanco-Aparicio , Juan Ignacio Aguiló-Anento , José Ángel Carretero-Gracia

Asthma is a disease that, due to its increasing prevalence and wide-ranging impact, continues to be studied in order to better understand its underlying mechanisms and thus improve both its management and the quality of life of those who suffer from it.

In the context of developing a document of recommendations based on expert opinion following the RAND/UCLA methodology through a Delphi survey on infection and asthma, this non-systematic review of the literature delves into the complex interactions between microorganisms and asthma, providing a comprehensive view, in question and answer mode, on six major aspects relating infection and asthma: 1) the possible infectious origin of asthma, with reference to the respiratory microbiota and the influence of certain respiratory viruses, 2) the role that certain immunodeficiencies may play in the development of bronchial hyperresponsiveness and bronchial infections, 3) the bidirectional association between bronchiectasis and asthma and its identification as a distinguishable phenotype, 4) the importance of the hypersecretory phenotype and infectious exacerbations in the control of asthma and in the assessment of the response to biological treatments, 5) the usefulness of infection prevention and treatment strategies to control asthma, and 6) the curious association between tuberculous infection and disease and the development of atopy and asthma.

哮喘是一种疾病，由于其日益流行和广泛的影响，继续进行研究，以便更好地了解其潜在机制，从而改善其管理和患者的生活质量。根据兰德/加州大学洛杉矶分校（RAND/UCLA）对感染和哮喘进行德尔菲调查的方法，根据专家意见制定了一份建议文件，在此背景下，本文对文献进行了非系统的回顾，深入研究了微生物与哮喘之间复杂的相互作用，以问答方式就与感染和哮喘有关的六个主要方面提供了全面的观点：1)哮喘可能的感染起源，与呼吸道微生物群和某些呼吸道病毒的影响有关；2)某些免疫缺陷可能在支气管高反应性和支气管感染的发展中起作用；3)支气管扩张与哮喘之间的双向关联及其作为可区分表型的鉴定。4)高分泌表型和感染加重在控制哮喘和评估生物治疗反应中的重要性，5)感染预防和治疗策略对控制哮喘的有用性，以及6)结核感染和疾病与特应性和哮喘发展之间的奇怪关联。

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引用次数: 0

Phage Therapy for Hospital-Acquired Respiratory Bacterial Infections: A Review 噬菌体治疗医院获得性呼吸道细菌感染的研究进展

Q4 Medicine

Open Respiratory Archives

Pub Date : 2025-10-24 DOI: 10.1016/j.opresp.2025.100507

Maria-Carmen Muñoz-Egea , Alianet Rodríguez , Jaime Esteban , Meritxell García-Quintanilla

Antibiotic-resistant respiratory infections necessitate alternative or adjunctive therapeutic strategies to reduce the bacterial burden in patients, particularly in the context of hospital-acquired infections. Bacteriophage therapy has emerged as a promising tool, with a resurgence of research in Western countries for various infectious diseases. The application of phage therapy against pulmonary infections has been primarily investigated for pathogens such as Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter baumannii in in vivo experiments and for Mycobacterium abscessus and P. aeruginosa in compassionate use cases. This review summarizes recent work on phage therapy targeting clinically relevant drug-resistant bacteria that cause nosocomial pulmonary infections, encompassing animal research, clinical cases, and clinical trials.

抗生素耐药呼吸道感染需要替代或辅助治疗策略，以减少患者的细菌负担，特别是在医院获得性感染的情况下。随着西方国家对各种传染病研究的复苏，噬菌体疗法已成为一种有前途的工具。噬菌体治疗肺部感染的应用主要研究了铜绿假单胞菌、肺炎克雷伯菌和鲍曼不动杆菌等病原体在体内实验中的应用，以及脓肿分枝杆菌和铜绿假单胞菌在同情用例中的应用。本文综述了近年来针对引起医院肺部感染的临床相关耐药细菌的噬菌体治疗的工作，包括动物研究、临床病例和临床试验。

引用次数: 0

Giant Bronchoesophageal Fistula in Advanced Lung Cancer: A Case Report 晚期肺癌巨大支气管食管瘘1例

Q4 Medicine

Open Respiratory Archives

Pub Date : 2025-10-24 DOI: 10.1016/j.opresp.2025.100508

Jorge Mora Pinilla , Fernando García Prieto , Diego Durán Barata , María Teresa Río Ramírez

引用次数: 0

Pulmonary Amyloidosis as a Differential Diagnosis in Interstitial Lung Diseases 肺淀粉样变与肺间质性疾病的鉴别诊断

Q4 Medicine

Open Respiratory Archives

Pub Date : 2025-10-16 DOI: 10.1016/j.opresp.2025.100506

Eva Cabrera-Cesar , Javier López Garcia , Ivan Perez de Pedro

Pulmonary amyloidosis is an uncommon condition that can mimic interstitial lung diseases (ILDs), leading to diagnostic delays. We describe two cases of diffuse alveoloseptal amyloidosis initially misdiagnosed as ILD. The first involved a 47-year-old woman with systemic AL amyloidosis, successfully treated with CyBorD (Cyclophosphamide, Bortezomib, Dexamethasone) and autologous stem cell transplantation. The second case was a 72-year-old man with localized pulmonary amyloidosis, managed empirically with azathioprine and prednisone, showing slow progression but clinical stability. Histological confirmation using Congo red staining and immunohistochemistry was essential for diagnosis, and systemic disease was excluded through a comprehensive workup. These cases highlight the importance of considering pulmonary amyloidosis in the differential diagnosis of ILDs, especially in patients with unexplained interstitial patterns and monoclonal gammopathy. A multidisciplinary approach is crucial to avoid inappropriate treatment and ensure timely management.

肺淀粉样变是一种罕见的疾病，可以模拟间质性肺疾病（ILDs），导致诊断延迟。我们报告两例弥漫性肺泡间隔淀粉样变最初误诊为ILD。第一例患者是一名47岁的系统性AL淀粉样变性女性，她成功地接受了CyBorD（环磷酰胺、硼替佐米、地塞米松）和自体干细胞移植治疗。第二例为72岁男性，局限性肺淀粉样变，经经验应用硫唑嘌呤和强的松治疗，进展缓慢，但临床稳定。使用刚果红染色和免疫组织化学进行组织学确认对诊断至关重要，通过全面检查排除全身性疾病。这些病例强调了考虑肺淀粉样变在ild鉴别诊断中的重要性，特别是在无法解释间质模式和单克隆γ病的患者中。多学科方法对于避免不当治疗和确保及时管理至关重要。

引用次数: 0

Investigating the Role of Obesity, Vitamin D Deficiency, and Eosinophilia in Pediatric Asthma Severity: A Cross-sectional Study 调查肥胖、维生素D缺乏和嗜酸性粒细胞增多在儿童哮喘严重程度中的作用：一项横断面研究

Q4 Medicine

Open Respiratory Archives

Pub Date : 2025-10-15 DOI: 10.1016/j.opresp.2025.100505

Mobina Rabiei , Maryam Mohammadi , Saeed Amini , Javad Nazari

Introduction

Modifiable factors such as obesity, vitamin D deficiency, and eosinophilia may contribute to increased asthma severity, but their combined impact remains underexplored, especially in resource-limited settings. This study aimed to investigate the independent and combined associations of obesity, vitamin D deficiency, and eosinophilia with asthma severity in children aged 6–18 years in Arak, Iran.

Material and methods

In this cross-sectional study, 177 children with physician-diagnosed asthma were recruited from the Amir-Kabir Hospital in 2024. Data on body mass index, serum 25-hydroxy vitamin D levels, and eosinophil counts were collected. Asthma severity was categorized as mild, moderate, or severe according to clinical guidelines. Statistical analyses included chi-square tests, ANOVA, and multivariate logistic regression adjusting for age, sex, and family history.

Results

The mean age of participants was 10.4 ± 3.1 years, and 69.5% were male. Overweight/obesity was observed in 30.5%, vitamin D deficiency in 56.5%, and eosinophilia in 10.2% of the children. Asthma severity was mild in 74.6%, moderate in 15.3%, and severe in 10.2% of cases. All three risk factors were significantly more prevalent in children with moderate–severe asthma (p < 0.001). Multivariate analysis revealed that overweight/obesity (adjusted overall risk (OR): 3.21; 95% confidence interval (95% CI): 1.87–5.51), vitamin D deficiency (adjusted OR: 2.76; 95% CI: 1.45–5.25), and eosinophilia (adjusted OR: 8.42; 95% CI: 3.24–21.89) were independently associated with increased asthma severity.

Conclusion

Obesity, vitamin D deficiency, and eosinophilia are independently associated with greater asthma severity in children. Addressing these risk factors through integrated clinical assessments and public health interventions may improve asthma outcomes.

可改变的因素如肥胖、维生素D缺乏和嗜酸性粒细胞增多可能导致哮喘严重程度增加，但它们的综合影响仍未得到充分探讨，特别是在资源有限的环境中。本研究旨在调查伊朗阿拉克6-18岁儿童中肥胖、维生素D缺乏和嗜酸性粒细胞增多与哮喘严重程度的独立和联合关联。材料和方法在这项横断面研究中，于2024年从Amir-Kabir医院招募了177名医生诊断为哮喘的儿童。收集体重指数、血清25-羟基维生素D水平和嗜酸性粒细胞计数数据。根据临床指南，哮喘严重程度分为轻度、中度和重度。统计分析包括卡方检验、方差分析和调整年龄、性别和家族史的多变量logistic回归。结果参与者平均年龄为10.4±3.1岁，男性占69.5%。超重/肥胖占30.5%，维生素D缺乏占56.5%，嗜酸性粒细胞增多占10.2%。轻度哮喘占74.6%，中度哮喘占15.3%，重度哮喘占10.2%。这三种危险因素在中重度哮喘患儿中更为普遍（p < 0.001）。多因素分析显示，超重/肥胖(调整总风险（OR）： 3.21；95%可信区间（95% CI）： 1.87-5.51)、维生素D缺乏（校正OR: 2.76; 95% CI: 1.45-5.25）和嗜酸性粒细胞增多（校正OR: 8.42; 95% CI: 3.24-21.89）与哮喘严重程度增加独立相关。结论肥胖、维生素D缺乏和嗜酸性粒细胞增多与儿童哮喘严重程度独立相关。通过综合临床评估和公共卫生干预措施解决这些风险因素可能会改善哮喘的预后。

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引用次数: 0

Bronchial Anthracostenosis: A Rare Entity 支气管炭疽管狭窄：一种罕见的疾病

Q4 Medicine

Open Respiratory Archives

Pub Date : 2025-10-14 DOI: 10.1016/j.opresp.2025.100504

Carla Nóvoa García, María José Bernabé Barrios, María Asunción Nieto Barbero

引用次数: 0

Highlights del 58.° Congreso de la Sociedad Española de Neumología y Cirugía Torácica (SEPAR) 第58集。西班牙肺病和胸外科学会（SEPAR）大会

Q4 Medicine

Open Respiratory Archives

Pub Date : 2025-10-09 DOI: 10.1016/j.opresp.2025.100501

David Peña-Otero , Andrés Tenes , María Dolores Martínez Pitarch , Teresa García-Barredo Restegui , Esperanza Salcedo Lobera , Marta Bascuas Arribas , Carmen Fernández-Arias , Ester Zamarrón de Lucas , Miguel Ángel Sánchez de Toro

The 58^th SEPAR Congress, held in Bilbao, June 2025, consolidated its position as a scientific benchmark and forum for interdisciplinary dialogue for the international respiratory community. New clinical guidelines, advances in respiratory care, cutting-edge technologies, e-health, accessibility to artificial intelligence applied to early diagnosis and telemonitoring, the ecosystemic approach, and equity applied to respiratory diseases were critically and constructively addressed.

Under the same theme, “Breathing Together”,’ the 8th SEPAR Patient Forum was held simultaneously, with active participation from the public, providing a transdisciplinary perspective and enabling their integration into healthcare management.

This article summarizes the most relevant aspects presented in 9 areas, in alphabetical order: asthma; pulmonary circulation; chronic obstructive pulmonary disease; respiratory nursing; respiratory physiotherapy; interventional pulmonology, lung function, and transplantation; pediatric pulmonology; thoracic oncology; tuberculosis, and respiratory infections.

第58届SEPAR大会于2025年6月在毕尔巴鄂举行，巩固了其作为国际呼吸界跨学科对话的科学基准和论坛的地位。新的临床指南、呼吸系统护理的进展、尖端技术、电子卫生、应用于早期诊断和远程监测的人工智能的可及性、生态系统方法以及应用于呼吸系统疾病的公平性得到了批判性和建设性的讨论。第八届SEPAR患者论坛以“一起呼吸”为主题，同时举行，公众积极参与，提供跨学科的视角，并使其融入医疗管理。本文总结了9个领域中最相关的方面，按字母顺序排列：哮喘；肺循环;慢性阻塞性肺病；呼吸道护理;呼吸理疗;介入肺脏学、肺功能和移植；小儿肺学;胸部肿瘤;肺结核和呼吸道感染。

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