Pub Date : 2025-12-19DOI: 10.1016/j.jdin.2025.12.003
Joong Heon Suh MD, PhD , Jungyoon Ohn MD, PhD , Keunyoung Hur MD , Je-Ho Mun MD, PhD
{"title":"Surgical management of green nail syndrome","authors":"Joong Heon Suh MD, PhD , Jungyoon Ohn MD, PhD , Keunyoung Hur MD , Je-Ho Mun MD, PhD","doi":"10.1016/j.jdin.2025.12.003","DOIUrl":"10.1016/j.jdin.2025.12.003","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"24 ","pages":"Pages 346-348"},"PeriodicalIF":5.2,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145976178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-17DOI: 10.1016/j.jdin.2025.11.028
Maria Angeliki Gkini MD, MSc, PhD , Helen Alexander MD , Maria Barfoot MSc , Alberto Barea RN, BSc, MSc , Paula E. Beattie MBBCh, BaO, BSc, MRCP, MD , Firas C. Kreeshan MBBS, MSc, MRCP , Deborah Moffitt BSc, MBBS, MRCP , Padma Mohandas MRCP, MRCGP, MSc , Andrew E. Pink BMed Sci (Hons), BMBS, PhD, MRCP , Andrew Proctor BSc (Hons) , Ann Sergeant MBChB , Laura J. Savage PhD
Background
Guidelines for the management and treatment of atopic dermatitis have been extensively published in Europe and globally, however these are not always relevant to the United Kingdom (UK) clinical setting.
Objectives
To develop consensus statements for the optimized management of adults and children with atopic dermatitis in the UK.
Method
Consensus statements were developed by an expert advisory panel following a targeted literature review, based on 5 topics (patient centric approach, assessing severity consistently, setting treatment targets, early intervention, and optimizing treatment). Consensus statements were voted on using a 5-point Likert scale in a Delphi over 3 rounds by 12 multidisciplinary, geographically spread participants. Consensus was reached if ≥75% of the voting participants rated the statement as 4 or 5.
Results
Strong consensus (≥90%) was achieved for 24 out of 27 statements. The level of consensus by topic was: Patient centric approach (92%-100%); Assessing severity consistently (75%-100%); Setting treatment targets (83%-100%); Intervening early (92%-100%); Optimizing treatment (92%).
Limitations
Due to the design and objectives of the study only a small number of participants were invited to take part.
Conclusions
The following recommendations have been developed to be practical and easy to implement within everyday clinical practice.
{"title":"Set targets, assess response, intervene early to achieve minimal disease activity in atopic dermatitis (STRIVE AD): A modified Delphi consensus project to optimize management of atopic dermatitis in the United Kingdom","authors":"Maria Angeliki Gkini MD, MSc, PhD , Helen Alexander MD , Maria Barfoot MSc , Alberto Barea RN, BSc, MSc , Paula E. Beattie MBBCh, BaO, BSc, MRCP, MD , Firas C. Kreeshan MBBS, MSc, MRCP , Deborah Moffitt BSc, MBBS, MRCP , Padma Mohandas MRCP, MRCGP, MSc , Andrew E. Pink BMed Sci (Hons), BMBS, PhD, MRCP , Andrew Proctor BSc (Hons) , Ann Sergeant MBChB , Laura J. Savage PhD","doi":"10.1016/j.jdin.2025.11.028","DOIUrl":"10.1016/j.jdin.2025.11.028","url":null,"abstract":"<div><h3>Background</h3><div>Guidelines for the management and treatment of atopic dermatitis have been extensively published in Europe and globally, however these are not always relevant to the United Kingdom (UK) clinical setting.</div></div><div><h3>Objectives</h3><div>To develop consensus statements for the optimized management of adults and children with atopic dermatitis in the UK.</div></div><div><h3>Method</h3><div>Consensus statements were developed by an expert advisory panel following a targeted literature review, based on 5 topics (patient centric approach, assessing severity consistently, setting treatment targets, early intervention, and optimizing treatment). Consensus statements were voted on using a 5-point Likert scale in a Delphi over 3 rounds by 12 multidisciplinary, geographically spread participants. Consensus was reached if ≥75% of the voting participants rated the statement as 4 or 5.</div></div><div><h3>Results</h3><div>Strong consensus (≥90%) was achieved for 24 out of 27 statements. The level of consensus by topic was: Patient centric approach (92%-100%); Assessing severity consistently (75%-100%); Setting treatment targets (83%-100%); Intervening early (92%-100%); Optimizing treatment (92%).</div></div><div><h3>Limitations</h3><div>Due to the design and objectives of the study only a small number of participants were invited to take part.</div></div><div><h3>Conclusions</h3><div>The following recommendations have been developed to be practical and easy to implement within everyday clinical practice.</div></div>","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"25 ","pages":"Pages 56-68"},"PeriodicalIF":5.2,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146080314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-17DOI: 10.1016/j.jdin.2025.11.027
Dezhao Bi MMed , Songmao Hua MMed , Yunyao Hu MMed , Jinrui Zhang MMed , Haolong Ran MMed , Lei Han MMed , Jin Tong Tey MMed , Shun Guo MD
{"title":"Global, regional, and national burden of alopecia areata from 1990 to 2021: An analysis from the Global Burden of Disease Study 2021","authors":"Dezhao Bi MMed , Songmao Hua MMed , Yunyao Hu MMed , Jinrui Zhang MMed , Haolong Ran MMed , Lei Han MMed , Jin Tong Tey MMed , Shun Guo MD","doi":"10.1016/j.jdin.2025.11.027","DOIUrl":"10.1016/j.jdin.2025.11.027","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"24 ","pages":"Pages 326-328"},"PeriodicalIF":5.2,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-16DOI: 10.1016/j.jdin.2025.11.026
Carlota Abbad-Jaime de Aragon PhD , Emilio Berna-Rico MD, PhD , Alba Lecumberri MD , Javier Perez-Bootello MD , María Davó-Mogica MSc , Fernando Neria-Serrano PhD , Diana Monge MD , María Asunción Ballester-Martínez MD , Cristina Pindado-Ortega MD, PhD , María Castellanos-González MD, PhD , Mar Llamas-Velasco MD, PhD , Samantha Wasniewski MD, PhD , María G. Barderas PhD , Pedro Jaén MD, PhD , Joel M. Gelfand MD, MSCE , Nehal N. Mehta MD, MSCE , Jorge Solís MD, PhD , Leticia Fernández-Friera MD, PhD , Álvaro González-Cantero MD, PhD
Background
Psoriasis increases atherosclerosis risk due to inflammation. To date, subclinical atherosclerosis (SA) in psoriasis has only been studied in individual vascular territories by imaging.
Objective
To conduct a comprehensive evaluation of multiterritorial SA prevalence in psoriasis by imaging and establish its relationships with cardiovascular (CV) risk scores.
Methods
A total of 120 patients with moderate-to-severe psoriasis without CV disease from the Early Detection of Subclinical Atherosclerosis in Psoriasis (EDSAP) cohort underwent vascular ultrasound of carotid/femoral arteries and noncontrast/contrast-coronary computed tomography angiography. SA was defined by the presence of any plaque or a coronary artery calcium score ≥1.
Results
The median age was 48.04 (8.25) years, 73% were male, and 77% of participants had SA. Femoral arteries were most affected (57.1%), followed by the coronaries (51.3%) and carotid arteries (49.6%). Femoral plaques exhibited the strongest associations with coronary parameters. CV risk scores underestimated SA, as at least 60% low-risk and 90% moderate-risk patients had SA.
Limitations
The main limitation is the small sample size.
Conclusions
This study provides the first multiterritorial assessment of SA in psoriasis, revealing a high prevalence of early disease. Femoral arteries were most affected, correlating with coronary atherosclerosis. The high SA detection within low-/intermediate-risk individuals suggests recalibrating CV scores for establishing effective preventive measures.
{"title":"Prevalence, multiterritorial vascular distribution, and burden of subclinical atherosclerosis in psoriasis: The EDSAP study","authors":"Carlota Abbad-Jaime de Aragon PhD , Emilio Berna-Rico MD, PhD , Alba Lecumberri MD , Javier Perez-Bootello MD , María Davó-Mogica MSc , Fernando Neria-Serrano PhD , Diana Monge MD , María Asunción Ballester-Martínez MD , Cristina Pindado-Ortega MD, PhD , María Castellanos-González MD, PhD , Mar Llamas-Velasco MD, PhD , Samantha Wasniewski MD, PhD , María G. Barderas PhD , Pedro Jaén MD, PhD , Joel M. Gelfand MD, MSCE , Nehal N. Mehta MD, MSCE , Jorge Solís MD, PhD , Leticia Fernández-Friera MD, PhD , Álvaro González-Cantero MD, PhD","doi":"10.1016/j.jdin.2025.11.026","DOIUrl":"10.1016/j.jdin.2025.11.026","url":null,"abstract":"<div><h3>Background</h3><div>Psoriasis increases atherosclerosis risk due to inflammation. To date, subclinical atherosclerosis (SA) in psoriasis has only been studied in individual vascular territories by imaging.</div></div><div><h3>Objective</h3><div>To conduct a comprehensive evaluation of multiterritorial SA prevalence in psoriasis by imaging and establish its relationships with cardiovascular (CV) risk scores.</div></div><div><h3>Methods</h3><div>A total of 120 patients with moderate-to-severe psoriasis without CV disease from the Early Detection of Subclinical Atherosclerosis in Psoriasis (EDSAP) cohort underwent vascular ultrasound of carotid/femoral arteries and noncontrast/contrast-coronary computed tomography angiography. SA was defined by the presence of any plaque or a coronary artery calcium score ≥1.</div></div><div><h3>Results</h3><div>The median age was 48.04 (8.25) years, 73% were male, and 77% of participants had SA. Femoral arteries were most affected (57.1%), followed by the coronaries (51.3%) and carotid arteries (49.6%). Femoral plaques exhibited the strongest associations with coronary parameters. CV risk scores underestimated SA, as at least 60% low-risk and 90% moderate-risk patients had SA.</div></div><div><h3>Limitations</h3><div>The main limitation is the small sample size.</div></div><div><h3>Conclusions</h3><div>This study provides the first multiterritorial assessment of SA in psoriasis, revealing a high prevalence of early disease. Femoral arteries were most affected, correlating with coronary atherosclerosis. The high SA detection within low-/intermediate-risk individuals suggests recalibrating CV scores for establishing effective preventive measures.</div></div>","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"25 ","pages":"Pages 44-55"},"PeriodicalIF":5.2,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146039511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-13DOI: 10.1016/j.jdin.2025.11.025
Zheng Su MB, Chen Sun MB, Wen-Hui Yao MB, Pan Wang MB, Yue-Ping Zeng MD
{"title":"Off-label use of abrocitinib in dermatology: A systematic literature review with narrative summary","authors":"Zheng Su MB, Chen Sun MB, Wen-Hui Yao MB, Pan Wang MB, Yue-Ping Zeng MD","doi":"10.1016/j.jdin.2025.11.025","DOIUrl":"10.1016/j.jdin.2025.11.025","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"24 ","pages":"Pages 315-317"},"PeriodicalIF":5.2,"publicationDate":"2025-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145920683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-10DOI: 10.1016/j.jdin.2025.11.022
Karen Louise Herbst MD, PhD , Yu-Fang Ling MS , An-Yi Sheu MS , Daniel Isaac Schlessinger MD , Szu-Yi Wu BA
{"title":"Efficacy and safety of CBL-514 for Dercum disease lipomas: A randomized phase 2a study","authors":"Karen Louise Herbst MD, PhD , Yu-Fang Ling MS , An-Yi Sheu MS , Daniel Isaac Schlessinger MD , Szu-Yi Wu BA","doi":"10.1016/j.jdin.2025.11.022","DOIUrl":"10.1016/j.jdin.2025.11.022","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"25 ","pages":"Pages 1-4"},"PeriodicalIF":5.2,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145986690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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