Pub Date : 2025-11-03DOI: 10.1016/j.jdin.2025.10.015
Benjamin D. Hu BS , Brandon R. Block BA , Grace Rabinowitz BA , Raphaella Lambert BA , Andrew Zhu MSc , Hannah Verma BA , Jón Gunnlaugur Jónasson MD , Bardur Sigurgeirsson MD, PhD , Shane Meehan MD , Jonathan Ungar MD , Jesse M. Lewin MD , Nicholas Gulati MD, PhD , Jonas A. Adalsteinsson MD, PhD
{"title":"Relative survival analysis of Merkel cell carcinoma across intersectional demographics using the Surveillance, Epidemiology, and End Results (SEER) database","authors":"Benjamin D. Hu BS , Brandon R. Block BA , Grace Rabinowitz BA , Raphaella Lambert BA , Andrew Zhu MSc , Hannah Verma BA , Jón Gunnlaugur Jónasson MD , Bardur Sigurgeirsson MD, PhD , Shane Meehan MD , Jonathan Ungar MD , Jesse M. Lewin MD , Nicholas Gulati MD, PhD , Jonas A. Adalsteinsson MD, PhD","doi":"10.1016/j.jdin.2025.10.015","DOIUrl":"10.1016/j.jdin.2025.10.015","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"24 ","pages":"Pages 126-128"},"PeriodicalIF":5.2,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145615323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-03DOI: 10.1016/j.jdin.2025.10.014
Veena Vanchinathan MD , Michael Hartmann MS , Noah M. Contreras BS , Andrew L. Avins MD, MPH , Amara A. Lieberman MD
{"title":"Clinical practice style is associated with greater isotretinoin use for acne in an integrated health system: An ecological study","authors":"Veena Vanchinathan MD , Michael Hartmann MS , Noah M. Contreras BS , Andrew L. Avins MD, MPH , Amara A. Lieberman MD","doi":"10.1016/j.jdin.2025.10.014","DOIUrl":"10.1016/j.jdin.2025.10.014","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"24 ","pages":"Pages 166-168"},"PeriodicalIF":5.2,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145614354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-28DOI: 10.1016/j.jdin.2025.10.008
Chang Chuen Tan , Krystal Valerie Soh , Eugene Wang , Ellie Ci-En Choi MBBS, MMed, MRCP, MCI
Background
Stress is a well-established trigger for many skin diseases; yet its biological mechanisms are poorly understood.
Objective
To synthesize current evidence on brain-skin pathways, emphasizing key mediators and feedback loops that explain how stress exacerbates skin disease and vice versa.
Methods
A comprehensive search through August 25, 2025, using terms related to brain-skin communication, psychodermatology, and stress-related pathophysiology included both in-vivo and in-vitro animal and human studies.
Results
159 articles were included and synthesized. Key findings highlight a bidirectional brain-skin axis involving the brain and pituitary, adrenal glands, peripheral nerves and skin. Stress triggers the brain and pituitary to release corticotropin-releasing hormone and adrenocorticotropic hormone; adrenal glands to secrete cortisol, catecholamines and androgens; and peripheral nerves to release neuropeptides such as Substance P and calcitonin gene-related peptide. These are implicated in skin inflammation while skin-derived mediators (cytokines, chemokines, neurotrophins) may disrupt and cross the blood-brain barrier, amplifying neuroinflammation, and psychiatric symptoms. Together, these form a self-sustaining feedback perpetuating both dermatologic and psychological disease.
Limitations
Much of the mechanistic understanding is derived from animal models; high-quality human data remain limited.
Conclusion
Understanding the brain-skin axis identifies therapeutic targets and guides future research on stress-related skin disease.
{"title":"The brain-skin connection: A narrative review of neuroendocrine and immune pathways","authors":"Chang Chuen Tan , Krystal Valerie Soh , Eugene Wang , Ellie Ci-En Choi MBBS, MMed, MRCP, MCI","doi":"10.1016/j.jdin.2025.10.008","DOIUrl":"10.1016/j.jdin.2025.10.008","url":null,"abstract":"<div><h3>Background</h3><div>Stress is a well-established trigger for many skin diseases; yet its biological mechanisms are poorly understood.</div></div><div><h3>Objective</h3><div>To synthesize current evidence on brain-skin pathways, emphasizing key mediators and feedback loops that explain how stress exacerbates skin disease and vice versa.</div></div><div><h3>Methods</h3><div>A comprehensive search through August 25, 2025, using terms related to brain-skin communication, psychodermatology, and stress-related pathophysiology included both in-vivo and in-vitro animal and human studies.</div></div><div><h3>Results</h3><div>159 articles were included and synthesized. Key findings highlight a bidirectional brain-skin axis involving the brain and pituitary, adrenal glands, peripheral nerves and skin. Stress triggers the brain and pituitary to release corticotropin-releasing hormone and adrenocorticotropic hormone; adrenal glands to secrete cortisol, catecholamines and androgens; and peripheral nerves to release neuropeptides such as Substance P and calcitonin gene-related peptide. These are implicated in skin inflammation while skin-derived mediators (cytokines, chemokines, neurotrophins) may disrupt and cross the blood-brain barrier, amplifying neuroinflammation, and psychiatric symptoms. Together, these form a self-sustaining feedback perpetuating both dermatologic and psychological disease.</div></div><div><h3>Limitations</h3><div>Much of the mechanistic understanding is derived from animal models; high-quality human data remain limited.</div></div><div><h3>Conclusion</h3><div>Understanding the brain-skin axis identifies therapeutic targets and guides future research on stress-related skin disease.</div></div>","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"24 ","pages":"Pages 112-123"},"PeriodicalIF":5.2,"publicationDate":"2025-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145615222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The global hair color market is valued over 23 billion dollars with over 2 billion in sales in the United States. Permanent hair dye accounts for approximately 80% of hair dye products on the market.
Objective
To systematically review the association between hair dye use and cancer risk and identify vulnerable populations.
Methods
A systematic search of PubMed and MEDLINE from January 1964 to March 2025 was conducted. Articles were reviewed independently by 3 assessors.
Results
The review included 96 articles including 2 on both adults and children, and 5 on maternal exposure and pediatric cancer risk. Some studies suggested potential associations between hair dye use and cancer risk. Trends include increased risk of estrogen receptor + breast cancer among African American women and elevated bladder cancer in both genders. risk in frequent users. Individuals with slow acetylator N-acetyltransferase 2 genotypes or CYP1A2 had elevated cancer risk with dye use. Maternal use during the first trimester significantly increased offspring risk of acute lymphoblastic leukemia further elevated by continued use during lactation.
Limitations
Limitations include elements of study design, study populations, and confounders.
Conclusion
There is evidence to suggest possible increased cancer risks for frequent, long-term hair dye use in specific populations.
{"title":"Association between hair dye use and human cancers: A systematic review","authors":"Rachel K. Greene MD , Jalal Maghfour MD , Cristina Nguyen MD, MSBS, MHA , Gabrielle Baker BS , Natasha Atanaskova Mesinkovska MD, PhD","doi":"10.1016/j.jdin.2025.10.009","DOIUrl":"10.1016/j.jdin.2025.10.009","url":null,"abstract":"<div><h3>Background</h3><div>The global hair color market is valued over 23 billion dollars with over 2 billion in sales in the United States. Permanent hair dye accounts for approximately 80% of hair dye products on the market.</div></div><div><h3>Objective</h3><div>To systematically review the association between hair dye use and cancer risk and identify vulnerable populations.</div></div><div><h3>Methods</h3><div>A systematic search of PubMed and MEDLINE from January 1964 to March 2025 was conducted. Articles were reviewed independently by 3 assessors.</div></div><div><h3>Results</h3><div>The review included 96 articles including 2 on both adults and children, and 5 on maternal exposure and pediatric cancer risk. Some studies suggested potential associations between hair dye use and cancer risk. Trends include increased risk of estrogen receptor + breast cancer among African American women and elevated bladder cancer in both genders. risk in frequent users. Individuals with slow acetylator N-acetyltransferase 2 genotypes or <em>CYP1A2</em> had elevated cancer risk with dye use. Maternal use during the first trimester significantly increased offspring risk of acute lymphoblastic leukemia further elevated by continued use during lactation.</div></div><div><h3>Limitations</h3><div>Limitations include elements of study design, study populations, and confounders.</div></div><div><h3>Conclusion</h3><div>There is evidence to suggest possible increased cancer risks for frequent, long-term hair dye use in specific populations.</div></div>","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"24 ","pages":"Pages 205-233"},"PeriodicalIF":5.2,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145615226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-25DOI: 10.1016/j.jdin.2025.10.010
Mercedes Sanchez-Diaz MD , Juan Rivera-Quispe MD , Leandro Huayanay MD, MS , Erika Romero-Sandoval MD , Frine Samalvides MD, MS
{"title":"Efficacy and tolerability of cryosurgery followed by a topical agent for multiple actinic keratosis: A systematic review and network meta-analysis","authors":"Mercedes Sanchez-Diaz MD , Juan Rivera-Quispe MD , Leandro Huayanay MD, MS , Erika Romero-Sandoval MD , Frine Samalvides MD, MS","doi":"10.1016/j.jdin.2025.10.010","DOIUrl":"10.1016/j.jdin.2025.10.010","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"24 ","pages":"Pages 250-252"},"PeriodicalIF":5.2,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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