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Combination secukinumab and surgical intervention for moderate-to-severe hidradenitis suppurativa: A retrospective cohort study 联合secukinumab和手术干预治疗中重度化脓性汗腺炎：一项回顾性队列研究
IF 5.2
JAAD International
Pub Date : 2026-02-01 Epub Date: 2025-10-02 DOI: 10.1016/j.jdin.2025.08.014
Qiuyun Xu MD , Yifan Xie MD , Zhuo Chen MD , Fang Fang MD , Shuyi Shen MD , Songyu Wang MD , Chengbei Bao MD , Ying Zou PhD , Dan Deng PhD , Chao Ji MD, PhD , Ting Gong PhD
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引用次数: 0
The brain-skin connection: A narrative review of neuroendocrine and immune pathways 脑-皮肤连接：神经内分泌和免疫途径的叙述性回顾
IF 5.2
JAAD International
Pub Date : 2026-02-01 Epub Date: 2025-10-28 DOI: 10.1016/j.jdin.2025.10.008
Chang Chuen Tan , Krystal Valerie Soh , Eugene Wang , Ellie Ci-En Choi MBBS, MMed, MRCP, MCI

Background

Stress is a well-established trigger for many skin diseases; yet its biological mechanisms are poorly understood.

Objective

To synthesize current evidence on brain-skin pathways, emphasizing key mediators and feedback loops that explain how stress exacerbates skin disease and vice versa.

Methods

A comprehensive search through August 25, 2025, using terms related to brain-skin communication, psychodermatology, and stress-related pathophysiology included both in-vivo and in-vitro animal and human studies.

Results

159 articles were included and synthesized. Key findings highlight a bidirectional brain-skin axis involving the brain and pituitary, adrenal glands, peripheral nerves and skin. Stress triggers the brain and pituitary to release corticotropin-releasing hormone and adrenocorticotropic hormone; adrenal glands to secrete cortisol, catecholamines and androgens; and peripheral nerves to release neuropeptides such as Substance P and calcitonin gene-related peptide. These are implicated in skin inflammation while skin-derived mediators (cytokines, chemokines, neurotrophins) may disrupt and cross the blood-brain barrier, amplifying neuroinflammation, and psychiatric symptoms. Together, these form a self-sustaining feedback perpetuating both dermatologic and psychological disease.

Limitations

Much of the mechanistic understanding is derived from animal models; high-quality human data remain limited.

Conclusion

Understanding the brain-skin axis identifies therapeutic targets and guides future research on stress-related skin disease.
压力是许多皮肤疾病的公认诱因；然而，人们对其生物学机制知之甚少。目的综合目前关于脑-皮肤通路的证据，强调解释应激如何加剧皮肤疾病的关键介质和反馈回路，反之亦然。方法综合检索到2025年8月25日，使用脑-皮肤通讯、皮肤心理病学和应激相关病理生理学相关术语，包括体内和体外动物和人体研究。结果共纳入合成文献159篇。主要发现强调了一个双向脑-皮肤轴，涉及大脑、垂体、肾上腺、周围神经和皮肤。压力触发大脑和垂体释放促肾上腺皮质激素释放激素和促肾上腺皮质激素；肾上腺分泌皮质醇、儿茶酚胺和雄激素；和周围神经释放神经肽，如P物质和降钙素基因相关肽。这些与皮肤炎症有关，而皮肤来源的介质（细胞因子、趋化因子、神经营养因子）可能破坏并穿过血脑屏障，放大神经炎症和精神症状。总之，这些形成了一种自我维持的反馈，使皮肤和心理疾病永久化。局限性：大部分的机理理解来自于动物模型；高质量的人类数据仍然有限。结论认识脑-皮肤轴确定了应激相关皮肤病的治疗靶点，指导了今后应激相关皮肤病的研究。
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引用次数: 0
Rosacea prevalence, severity, and phenotype by race, ethnicity, and gender: A cross-sectional study of a diverse patient cohort within a primary care population 酒渣鼻的患病率、严重程度和表型与种族、民族和性别有关：一项对初级保健人群中不同患者队列的横断面研究
IF 5.2
JAAD International
Pub Date : 2026-02-01 Epub Date: 2025-11-27 DOI: 10.1016/j.jdin.2025.11.016
Alexander R. Gomez-Lara BA, BS , Adam Zakaria MD, MAS , Maria Elena Sanchez-Anguiano BS , Erin H. Amerson MD
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引用次数: 0
Atopic dermatitis beyond the skin: Characterizing skin pain in the “Scars of Life” study 皮肤以外的特应性皮炎：“生命的伤疤”研究中皮肤疼痛的特征
IF 5.2
JAAD International
Pub Date : 2026-02-01 Epub Date: 2025-10-14 DOI: 10.1016/j.jdin.2025.09.018
Jonathan I. Silverberg MD, PhD , Roberto Takaoka MD , Jerry Tan MD, FRCPC , Thomas Luger MD , Chaoying Gu MD, PhD , Roni Dodiuk-Gad MD , Flavia Pretti Aslanian MD, PhD , Cita Rosita Sigit Prakoeswa MD , Bruno Halioua MD , Ann’Laure Demessant Flavigny PhD , Caroline Le Floc’h PhD , Nabil Kerrouche PhD , Stéphanie Merhand PE , Wendy Smith Begolka PE , África Luca de Tena Smith PE , Shulamit Burstein PE , Delphine Kerob MD , Charles Taieb MD, PhD , Charbel Skayem MD , Therdpong Tempark MD , Laurent Misery MD, PhD (Pr)
{"title":"Atopic dermatitis beyond the skin: Characterizing skin pain in the “Scars of Life” study","authors":"Jonathan I. Silverberg MD, PhD ,&nbsp;Roberto Takaoka MD ,&nbsp;Jerry Tan MD, FRCPC ,&nbsp;Thomas Luger MD ,&nbsp;Chaoying Gu MD, PhD ,&nbsp;Roni Dodiuk-Gad MD ,&nbsp;Flavia Pretti Aslanian MD, PhD ,&nbsp;Cita Rosita Sigit Prakoeswa MD ,&nbsp;Bruno Halioua MD ,&nbsp;Ann’Laure Demessant Flavigny PhD ,&nbsp;Caroline Le Floc’h PhD ,&nbsp;Nabil Kerrouche PhD ,&nbsp;Stéphanie Merhand PE ,&nbsp;Wendy Smith Begolka PE ,&nbsp;África Luca de Tena Smith PE ,&nbsp;Shulamit Burstein PE ,&nbsp;Delphine Kerob MD ,&nbsp;Charles Taieb MD, PhD ,&nbsp;Charbel Skayem MD ,&nbsp;Therdpong Tempark MD ,&nbsp;Laurent Misery MD, PhD (Pr)","doi":"10.1016/j.jdin.2025.09.018","DOIUrl":"10.1016/j.jdin.2025.09.018","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"24 ","pages":"Pages 202-204"},"PeriodicalIF":5.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145614500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relative survival analysis of Merkel cell carcinoma across intersectional demographics using the Surveillance, Epidemiology, and End Results (SEER) database 使用监测、流行病学和最终结果（SEER）数据库对默克尔细胞癌进行交叉人口统计学的相对生存分析
IF 5.2
JAAD International
Pub Date : 2026-02-01 Epub Date: 2025-11-03 DOI: 10.1016/j.jdin.2025.10.015
Benjamin D. Hu BS , Brandon R. Block BA , Grace Rabinowitz BA , Raphaella Lambert BA , Andrew Zhu MSc , Hannah Verma BA , Jón Gunnlaugur Jónasson MD , Bardur Sigurgeirsson MD, PhD , Shane Meehan MD , Jonathan Ungar MD , Jesse M. Lewin MD , Nicholas Gulati MD, PhD , Jonas A. Adalsteinsson MD, PhD
{"title":"Relative survival analysis of Merkel cell carcinoma across intersectional demographics using the Surveillance, Epidemiology, and End Results (SEER) database","authors":"Benjamin D. Hu BS ,&nbsp;Brandon R. Block BA ,&nbsp;Grace Rabinowitz BA ,&nbsp;Raphaella Lambert BA ,&nbsp;Andrew Zhu MSc ,&nbsp;Hannah Verma BA ,&nbsp;Jón Gunnlaugur Jónasson MD ,&nbsp;Bardur Sigurgeirsson MD, PhD ,&nbsp;Shane Meehan MD ,&nbsp;Jonathan Ungar MD ,&nbsp;Jesse M. Lewin MD ,&nbsp;Nicholas Gulati MD, PhD ,&nbsp;Jonas A. Adalsteinsson MD, PhD","doi":"10.1016/j.jdin.2025.10.015","DOIUrl":"10.1016/j.jdin.2025.10.015","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"24 ","pages":"Pages 126-128"},"PeriodicalIF":5.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145615323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Supporting evidence and recommendations for the management of patients with systemic-eligible atopic dermatitis: A Canadian consensus document 对全身性特应性皮炎患者管理的支持证据和建议：加拿大共识文件
IF 5.2
JAAD International
Pub Date : 2026-02-01 Epub Date: 2025-09-26 DOI: 10.1016/j.jdin.2025.06.009
Kerri Purdy MD , Melinda Gooderham MD , Mohannad Abu-Hilal MD , April Armstrong MD , Rachel Asiniwasis MD , Gurbir Dhadwal MD , Carolyn Jack MD , Perla Lansang MD , Fiona Lovegrove MD , Julien Ringuet MD , Shanna Spring MD

Background

Atopic dermatitis is a chronic, relapsing, and remitting inflammatory skin disease. Multiple systemic therapeutic options are available to treat atopic dermatitis.

Objective

To provide evidence-based recommendations on the use of systemic therapies for atopic dermatitis in Canada that consider the nuances of the Canadian healthcare system and provide guidance for populations of clinical interest.

Methods

A panel of 14 experts, including 11 dermatologists from Canada and 3 from the United States, reviewed available literature on systemic therapies for atopic dermatitis. The published evidence, along with clinical expertise and opinion, was used to draft a concise set of statements to guide healthcare providers in Canada on systemic treatment of atopic dermatitis.

Results

During 3 rounds of virtual meetings with all 14 experts voting in all meetings, a total of 29 statements reached the 75% agreement required for consensus.

Limitations

The consensus statements are based on expert opinions and consensus in the absence of evidence-based clinical research for patient outcomes. The statements represent considerations for patient management and not specific guidelines for patient treatment.

Conclusion

The recommendations and statements provided serve to guide Canadian healthcare providers on the practical aspects of managing systemic-eligible patients with atopic dermatitis.
背景：过敏性皮炎是一种慢性、复发性、缓解性炎症性皮肤病。多种系统治疗方案可用于治疗特应性皮炎。目的考虑到加拿大医疗保健系统的细微差别，为加拿大特应性皮炎的全身治疗提供循证建议，并为临床人群提供指导。方法一个由14名专家组成的小组，包括11名来自加拿大的皮肤科医生和3名来自美国的皮肤科医生，回顾了有关特应性皮炎全身治疗的现有文献。已发表的证据，连同临床专业知识和意见，被用来起草一套简明的声明，以指导加拿大的医疗保健提供者对特应性皮炎的全身治疗。结果在3轮虚拟会议中，所有14位专家在所有会议中投票，共有29个发言达到了达成共识所需的75%的一致意见。局限性共识声明是基于专家意见和共识，缺乏对患者结果的循证临床研究。这些陈述代表了对患者管理的考虑，而不是对患者治疗的具体指导。结论提供的建议和声明有助于指导加拿大医疗保健提供者在管理系统符合条件的特应性皮炎患者的实践方面。
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引用次数: 0
Histopathologic features of nutritional deficiency dermatoses: A two-center series 营养缺乏性皮肤病的组织病理学特征：双中心系列
IF 5.2
JAAD International
Pub Date : 2026-02-01 Epub Date: 2025-11-20 DOI: 10.1016/j.jdin.2025.10.018
Silvija Milanovic BS , Emily Draper BA , Milbrey Parke MD , Catherine G. Chung MD , Abena Minta MD , Kiran Motaparthi MD
{"title":"Histopathologic features of nutritional deficiency dermatoses: A two-center series","authors":"Silvija Milanovic BS ,&nbsp;Emily Draper BA ,&nbsp;Milbrey Parke MD ,&nbsp;Catherine G. Chung MD ,&nbsp;Abena Minta MD ,&nbsp;Kiran Motaparthi MD","doi":"10.1016/j.jdin.2025.10.018","DOIUrl":"10.1016/j.jdin.2025.10.018","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"24 ","pages":"Pages 263-265"},"PeriodicalIF":5.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and tolerability of cryosurgery followed by a topical agent for multiple actinic keratosis: A systematic review and network meta-analysis 冷冻手术后局部用药治疗多发性光化性角化病的疗效和耐受性：一项系统综述和网络荟萃分析
IF 5.2
JAAD International
Pub Date : 2026-02-01 Epub Date: 2025-10-25 DOI: 10.1016/j.jdin.2025.10.010
Mercedes Sanchez-Diaz MD , Juan Rivera-Quispe MD , Leandro Huayanay MD, MS , Erika Romero-Sandoval MD , Frine Samalvides MD, MS
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引用次数: 0
Baseline expression levels of WNT8B, KRT2, and TTLL13P are associated with abrocitinib response in atopic dermatitis WNT8B、KRT2和TTLL13P的基线表达水平与特应性皮炎患者的阿布替尼应答相关
IF 5.2
JAAD International
Pub Date : 2026-02-01 Epub Date: 2025-10-22 DOI: 10.1016/j.jdin.2025.10.007
Yuwen Gao MD, Yang Luo MSc, Yingxia Gao BSN, Xingyu Chen MD, Yu Zhang MD, PhD, Yuan Zhou MD, PhD, Beilei Xu MD, PhD, Xu Yao MD, PhD, Xiaochun Liu MD, PhD
{"title":"Baseline expression levels of WNT8B, KRT2, and TTLL13P are associated with abrocitinib response in atopic dermatitis","authors":"Yuwen Gao MD,&nbsp;Yang Luo MSc,&nbsp;Yingxia Gao BSN,&nbsp;Xingyu Chen MD,&nbsp;Yu Zhang MD, PhD,&nbsp;Yuan Zhou MD, PhD,&nbsp;Beilei Xu MD, PhD,&nbsp;Xu Yao MD, PhD,&nbsp;Xiaochun Liu MD, PhD","doi":"10.1016/j.jdin.2025.10.007","DOIUrl":"10.1016/j.jdin.2025.10.007","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"24 ","pages":"Pages 191-193"},"PeriodicalIF":5.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145614353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical practice style is associated with greater isotretinoin use for acne in an integrated health system: An ecological study 临床实践风格与更大的异维甲酸使用痤疮在综合卫生系统：生态学研究
IF 5.2
JAAD International
Pub Date : 2026-02-01 Epub Date: 2025-11-03 DOI: 10.1016/j.jdin.2025.10.014
Veena Vanchinathan MD , Michael Hartmann MS , Noah M. Contreras BS , Andrew L. Avins MD, MPH , Amara A. Lieberman MD
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引用次数: 0
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