Pub Date : 2025-10-18DOI: 10.1016/j.jdin.2025.10.003
Yi-Han Chang MD , Yi-Hsuan Huang MD , Shin-Chen Pan MD, PhD , Julia Yu-Yun Lee MD , Cheng-Lin Wu MD , Tak-Wah Wong MD, PhD , Hsi-Huei Lu MD , Wei-Ting Liu MD
{"title":"Preoperative primary tumor SUVmax on PET/CT correlates with Breslow thickness and is associated with survival in melanoma: A retrospective cohort study","authors":"Yi-Han Chang MD , Yi-Hsuan Huang MD , Shin-Chen Pan MD, PhD , Julia Yu-Yun Lee MD , Cheng-Lin Wu MD , Tak-Wah Wong MD, PhD , Hsi-Huei Lu MD , Wei-Ting Liu MD","doi":"10.1016/j.jdin.2025.10.003","DOIUrl":"10.1016/j.jdin.2025.10.003","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"24 ","pages":"Pages 109-111"},"PeriodicalIF":5.2,"publicationDate":"2025-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145615227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-16DOI: 10.1016/j.jdin.2025.09.020
Zhichao Wang MD , Xing Hu MD, PhD , Haoyang Mo MD , Minxue Shen PhD , Carlos G. Romo MD, PhD , Katya Vera BA , Zhixiong Liu MD, PhD , Qingfeng Li MD, PhD , Chuntao Li MD, PhD , Kavita Y. Sarin MD, PhD
Background
Neurofibromatosis type 1 (NF1) is a multisystemic genetic disorder characterized by NF1 gene mutations. The well-described manifestations of NF1 are primarily derived from European populations.
Objective
To evaluate the phenotypic characteristics of Chinese patients with NF1.
Methods
This cross-sectional, multicenter study involved patients with NF1 from Chinese and U.S. populations. Clinical data were obtained from NF1 clinics and patient-reported outcome assessments.
Findings
1313 patients with Chinese NF1 were included. We found that Chinese patients were diagnosed later in life and exhibited a lower prevalence of spinal neurofibromas and fractures but a higher rate of malignant peripheral nerve sheath tumors as compared to U.S. patients. Four distinct NF1 subtypes were identified: severe neural, cutaneous, hereditary, and mild. Significant correlations were observed between freckles and cutaneous neurofibromas and between bone lesions and pseudarthrosis. Cutaneous manifestations were correlated with systemic manifestations, and the risk of developing plexiform neurofibromas was inversely proportional to the number of cutaneous neurofibromas and freckles.
Limitations
The use of self-report data may introduce subjectivity and recall bias.
Conclusion
This study provides the first comprehensive analysis of clinical phenotypes in Chinese patients with NF1. The identification of distinct NF1 subtypes, phenotypic correlations, and ethnic differences supports more personalized management strategies for NF1 patients.
{"title":"Phenotypic characterization of neurofibromatosis type 1 in a large Chinese cohort: A cross-sectional study","authors":"Zhichao Wang MD , Xing Hu MD, PhD , Haoyang Mo MD , Minxue Shen PhD , Carlos G. Romo MD, PhD , Katya Vera BA , Zhixiong Liu MD, PhD , Qingfeng Li MD, PhD , Chuntao Li MD, PhD , Kavita Y. Sarin MD, PhD","doi":"10.1016/j.jdin.2025.09.020","DOIUrl":"10.1016/j.jdin.2025.09.020","url":null,"abstract":"<div><h3>Background</h3><div>Neurofibromatosis type 1 (NF1) is a multisystemic genetic disorder characterized by <em>NF1</em> gene mutations. The well-described manifestations of NF1 are primarily derived from European populations.</div></div><div><h3>Objective</h3><div>To evaluate the phenotypic characteristics of Chinese patients with NF1.</div></div><div><h3>Methods</h3><div>This cross-sectional, multicenter study involved patients with NF1 from Chinese and U.S. populations. Clinical data were obtained from NF1 clinics and patient-reported outcome assessments.</div></div><div><h3>Findings</h3><div>1313 patients with Chinese NF1 were included. We found that Chinese patients were diagnosed later in life and exhibited a lower prevalence of spinal neurofibromas and fractures but a higher rate of malignant peripheral nerve sheath tumors as compared to U.S. patients. Four distinct NF1 subtypes were identified: severe neural, cutaneous, hereditary, and mild. Significant correlations were observed between freckles and cutaneous neurofibromas and between bone lesions and pseudarthrosis. Cutaneous manifestations were correlated with systemic manifestations, and the risk of developing plexiform neurofibromas was inversely proportional to the number of cutaneous neurofibromas and freckles.</div></div><div><h3>Limitations</h3><div>The use of self-report data may introduce subjectivity and recall bias.</div></div><div><h3>Conclusion</h3><div>This study provides the first comprehensive analysis of clinical phenotypes in Chinese patients with NF1. The identification of distinct NF1 subtypes, phenotypic correlations, and ethnic differences supports more personalized management strategies for NF1 patients.</div></div>","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"24 ","pages":"Pages 181-190"},"PeriodicalIF":5.2,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145615225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-16DOI: 10.1016/j.jdin.2025.10.001
Jacqueline Penn MD , Kathryn Achuck MD , Christine Deng BS , Richard Hass PhD , Elizabeth Jones MD
{"title":"Use of hybrid versus video-only teledermatology varies by condition: A cross-sectional study of 2064 encounters","authors":"Jacqueline Penn MD , Kathryn Achuck MD , Christine Deng BS , Richard Hass PhD , Elizabeth Jones MD","doi":"10.1016/j.jdin.2025.10.001","DOIUrl":"10.1016/j.jdin.2025.10.001","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"24 ","pages":"Pages 124-125"},"PeriodicalIF":5.2,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145615229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-14DOI: 10.1016/j.jdin.2025.09.019
Yuming Sun PhD , Zehao Luo MD , Furong Zeng PhD , Guangtong Deng PhD
{"title":"Nonkeratinocyte skin cancer in survivors of childhood, adolescent, and young adult cancer with and without radiotherapy","authors":"Yuming Sun PhD , Zehao Luo MD , Furong Zeng PhD , Guangtong Deng PhD","doi":"10.1016/j.jdin.2025.09.019","DOIUrl":"10.1016/j.jdin.2025.09.019","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"24 ","pages":"Pages 92-94"},"PeriodicalIF":5.2,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145520945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-13DOI: 10.1016/j.jdin.2025.09.017
Jia Yi Chua BSocSci (Hons) , Valencia Long MBBS, MRCP , Pei Ming Yeo MBBS, MRCP , Jiayan Ding MBBS candidate , Janet Dua MBBS, MRCP , Nisha Suyien Chandran MBBS, MRCP , Qasrina Lim BSc, MPH , Hui Xin See Tow MBBS candidate , Wilson Sim MBBS , Wan Ing Chong BCouns (Hons), MA (Applied Psych) , Oliver Suendermann PhD, D.Clin.Psy, Diplom-Psychologe , Diego Pitta De Araujo PhD , Jose Maria Valderas MBBS, PhD , Phillip Phan PhD , Kean J. Hsu PhD , Ellie Choi MBBS, MRCP
Background
Although cognitive and behavioral factors significantly impact dermatological outcomes, psychobehavioral interventions remain inaccessible and underused.
Objective
To develop and test a psychobehavioral intervention (MindMySkin) delivered via a mobile application.
Methods
Needs assessment, evidence-based module development, and formative user-centered evaluation were conducted in participants with eczema, psoriasis, or chronic urticaria. The developed prototype modules were further iteratively refined following additional qualitative and quantitative feedback.
Results
27 participants contributed to 24 1:1 interviews and 231 responses between June 2023 and November 2024. Modules were highly rated (median score 4 or 5/5) for utility, interest, understandability, and recommendation for inclusion, underscoring strong acceptability. Participants valued the informative content and conversational tone but highlighted skepticism toward reflection exercises and oversimplification of patient difficulties. Design challenges include balancing time demanding but effective modules with shorter more appealing content. The final intervention comprised 74 modules addressing illness coherence, symptom management, functional impairment, emotional impairment, and the patient–physician relationship.
Limitations
No participant reviewed the full program and modules were assigned, limiting insights on voluntary adherence.
Conclusion
This study establishes the unmet need for psychotherapeutic support and demonstrates the acceptability, appropriateness, and usability of a self-administered psychobehavioral intervention in improving dermatological care.
{"title":"Digital psychotherapeutic interventions to reduce dermatological symptom burden: Development and testing of MindMySkin","authors":"Jia Yi Chua BSocSci (Hons) , Valencia Long MBBS, MRCP , Pei Ming Yeo MBBS, MRCP , Jiayan Ding MBBS candidate , Janet Dua MBBS, MRCP , Nisha Suyien Chandran MBBS, MRCP , Qasrina Lim BSc, MPH , Hui Xin See Tow MBBS candidate , Wilson Sim MBBS , Wan Ing Chong BCouns (Hons), MA (Applied Psych) , Oliver Suendermann PhD, D.Clin.Psy, Diplom-Psychologe , Diego Pitta De Araujo PhD , Jose Maria Valderas MBBS, PhD , Phillip Phan PhD , Kean J. Hsu PhD , Ellie Choi MBBS, MRCP","doi":"10.1016/j.jdin.2025.09.017","DOIUrl":"10.1016/j.jdin.2025.09.017","url":null,"abstract":"<div><h3>Background</h3><div>Although cognitive and behavioral factors significantly impact dermatological outcomes, psychobehavioral interventions remain inaccessible and underused.</div></div><div><h3>Objective</h3><div>To develop and test a psychobehavioral intervention (MindMySkin) delivered via a mobile application.</div></div><div><h3>Methods</h3><div>Needs assessment, evidence-based module development, and formative user-centered evaluation were conducted in participants with eczema, psoriasis, or chronic urticaria. The developed prototype modules were further iteratively refined following additional qualitative and quantitative feedback.</div></div><div><h3>Results</h3><div>27 participants contributed to 24 1:1 interviews and 231 responses between June 2023 and November 2024. Modules were highly rated (median score 4 or 5/5) for utility, interest, understandability, and recommendation for inclusion, underscoring strong acceptability. Participants valued the informative content and conversational tone but highlighted skepticism toward reflection exercises and oversimplification of patient difficulties. Design challenges include balancing time demanding but effective modules with shorter more appealing content. The final intervention comprised 74 modules addressing illness coherence, symptom management, functional impairment, emotional impairment, and the patient–physician relationship.</div></div><div><h3>Limitations</h3><div>No participant reviewed the full program and modules were assigned, limiting insights on voluntary adherence.</div></div><div><h3>Conclusion</h3><div>This study establishes the unmet need for psychotherapeutic support and demonstrates the acceptability, appropriateness, and usability of a self-administered psychobehavioral intervention in improving dermatological care.</div></div>","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"24 ","pages":"Pages 134-146"},"PeriodicalIF":5.2,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145615221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-10DOI: 10.1016/j.jdin.2025.09.014
Marianne Cortes DO , Jorge O. Santana BA , John Strasswimmer MD, PhD
{"title":"Neoadjuvant cemiplimab to facilitate Mohs micrographic surgery tumor extirpation and reduce surgical morbidity","authors":"Marianne Cortes DO , Jorge O. Santana BA , John Strasswimmer MD, PhD","doi":"10.1016/j.jdin.2025.09.014","DOIUrl":"10.1016/j.jdin.2025.09.014","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"24 ","pages":"Pages 90-91"},"PeriodicalIF":5.2,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145520946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-10DOI: 10.1016/j.jdin.2025.09.016
Clayton Frazier MS , Congcong Miao MS , Sara Shalin MD, PhD , Hanna Jensen MD, PhD , Emily Frazier PhD
{"title":"A network-based cross-sectional study of geographic access disparities to Medicare-participating dermatologists in the United States","authors":"Clayton Frazier MS , Congcong Miao MS , Sara Shalin MD, PhD , Hanna Jensen MD, PhD , Emily Frazier PhD","doi":"10.1016/j.jdin.2025.09.016","DOIUrl":"10.1016/j.jdin.2025.09.016","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"24 ","pages":"Pages 70-72"},"PeriodicalIF":5.2,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145468582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-09DOI: 10.1016/j.jdin.2025.09.015
Ravi Ramessur MD, PhD , Zelma C. Chiesa Fuxench MD, MSCE , Daniel Shin PhD , Jennifer B. Mason MPH , Anabel C. Mason BS, BA , Maryte Papadopoulos MBE , Bruna Galvao de Oliveira Wafae MD, MMSc , Megan H. Noe MD, MPH, MSCE , Joel M. Gelfand MD, MSCE
{"title":"Deucravacitinib for the treatment of moderate-to-severe palmoplantar pustulosis: Results from an early-terminated open-label trial","authors":"Ravi Ramessur MD, PhD , Zelma C. Chiesa Fuxench MD, MSCE , Daniel Shin PhD , Jennifer B. Mason MPH , Anabel C. Mason BS, BA , Maryte Papadopoulos MBE , Bruna Galvao de Oliveira Wafae MD, MMSc , Megan H. Noe MD, MPH, MSCE , Joel M. Gelfand MD, MSCE","doi":"10.1016/j.jdin.2025.09.015","DOIUrl":"10.1016/j.jdin.2025.09.015","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"24 ","pages":"Pages 84-86"},"PeriodicalIF":5.2,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145468037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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