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Bisected full-thickness skin graft for reconstruction after Mohs micrographic surgery 莫氏显微外科手术后用于重建的分段全厚皮肤移植术
JAAD International
Pub Date : 2024-09-07 DOI: 10.1016/j.jdin.2024.08.008
Hoon Choi MD, Jun Ho Kwak MD, In Ho Bae MD, Chan-Ho Na MD, Bong Seok Shin MD, PhD, Min Sung Kim MD, PhD
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引用次数: 0
Demographics and lifestyle factors of patients with hidradenitis suppurativa: An All of Us database analysis 化脓性扁桃体炎患者的人口统计学和生活方式因素：我们所有人数据库分析
JAAD International
Pub Date : 2024-09-03 DOI: 10.1016/j.jdin.2024.08.002
Gaurav N. Pathak PharmD , Timothy Makkar MD , Suraj S. Pathak BS , Shazli Razi MD , Cindy Wassef MD , Babar Rao MD
{"title":"Demographics and lifestyle factors of patients with hidradenitis suppurativa: An All of Us database analysis","authors":"Gaurav N. Pathak PharmD , Timothy Makkar MD , Suraj S. Pathak BS , Shazli Razi MD , Cindy Wassef MD , Babar Rao MD","doi":"10.1016/j.jdin.2024.08.002","DOIUrl":"10.1016/j.jdin.2024.08.002","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"17 ","pages":"Pages 67-70"},"PeriodicalIF":0.0,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk factors that limit use of oral JAK inhibitors in chronic hand eczema: Findings from the Danish Skin Cohort 限制慢性手部湿疹患者使用口服 JAK 抑制剂的风险因素：丹麦皮肤队列研究结果
JAAD International
Pub Date : 2024-09-02 DOI: 10.1016/j.jdin.2024.08.006
Yuki M.F. Andersen MD, PhD , Johan Sieborg MSc , Lea Nymand MSc , Tiago Torres MD, PhD , Andrea Chiricozzi MD , Simon Francis Thomsen MD, PhD, DMSc , Jacob P. Thyssen MD, PhD, DMSc , Alexander Egeberg MD, PhD, DMSc

Background

Oral Janus kinase inhibitors (JAKis) have black-box warnings of infections, cancer risk, and cardiovascular and venous thromboembolic events. They may be used off-label for chronic hand eczema (CHE).

Objectives

Assess the prevalence of risk factors potentially impacting oral JAKi safety in CHE patients.

Methods

In the Danish Skin Cohort, CHE patients were examined for risk factors affecting oral JAKi use at baseline and followed for 12 months. Data were collected through register linkage (eg, cancer history) and through patient interviews (eg, smoking habits).

Results

Of 941 adults with CHE (66.2% women; mean age 55.5 [SD 13.3] years), 768 (81.6%) patients had at least one risk factor potentially impacting oral JAKi use, of which 682 (72.5%) had nonmodifiable risk factors. Most common risk factors were current or former heavy smoking (62.8%, n = 591), obesity (28.1%, n = 264), hypercholesterolemia (21.5%, n = 202), and hypertension (18.8%, n = 177). Among patients without any risk factors at baseline (n = 173), 20.2% (n = 35) developed ≥1 risk factor during the following 12 months.

Limitations

Certain risk factors may be underreported.

Conclusion

Most CHE patients have risk factors limiting appropriateness of oral JAKi use. Health care providers should assess risk factors in their patients when choosing treatment for CHE.
背景口服 Janus 激酶抑制剂 (JAKis) 有感染、癌症风险、心血管和静脉血栓栓塞事件的黑框警告。目的 评估可能影响慢性手部湿疹（CHE）患者口服 JAKi 安全性的风险因素的普遍性。方法 在丹麦皮肤队列中，对慢性手部湿疹患者进行基线调查，了解影响口服 JAKi 的风险因素，并随访 12 个月。结果在941名成年CHE患者（66.2%为女性；平均年龄55.5 [SD 13.3]岁）中，768名患者（81.6%）至少有一个风险因素可能影响口服JAKi的使用，其中682名患者（72.5%）有不可改变的风险因素。最常见的风险因素是目前或曾经大量吸烟（62.8%，n = 591）、肥胖（28.1%，n = 264）、高胆固醇血症（21.5%，n = 202）和高血压（18.8%，n = 177）。在基线时无任何危险因素的患者（n = 173）中，20.2%（n = 35）的患者在随后的 12 个月中出现了≥1 个危险因素。医疗服务提供者在选择CHE治疗方法时应评估患者的风险因素。
{"title":"Risk factors that limit use of oral JAK inhibitors in chronic hand eczema: Findings from the Danish Skin Cohort","authors":"Yuki M.F. Andersen MD, PhD ,&nbsp;Johan Sieborg MSc ,&nbsp;Lea Nymand MSc ,&nbsp;Tiago Torres MD, PhD ,&nbsp;Andrea Chiricozzi MD ,&nbsp;Simon Francis Thomsen MD, PhD, DMSc ,&nbsp;Jacob P. Thyssen MD, PhD, DMSc ,&nbsp;Alexander Egeberg MD, PhD, DMSc","doi":"10.1016/j.jdin.2024.08.006","DOIUrl":"10.1016/j.jdin.2024.08.006","url":null,"abstract":"<div><h3>Background</h3><div>Oral Janus kinase inhibitors (JAKis) have black-box warnings of infections, cancer risk, and cardiovascular and venous thromboembolic events. They may be used off-label for chronic hand eczema (CHE).</div></div><div><h3>Objectives</h3><div>Assess the prevalence of risk factors potentially impacting oral JAKi safety in CHE patients.</div></div><div><h3>Methods</h3><div>In the Danish Skin Cohort, CHE patients were examined for risk factors affecting oral JAKi use at baseline and followed for 12 months. Data were collected through register linkage (eg, cancer history) and through patient interviews (eg, smoking habits).</div></div><div><h3>Results</h3><div>Of 941 adults with CHE (66.2% women; mean age 55.5 [SD 13.3] years), 768 (81.6%) patients had at least one risk factor potentially impacting oral JAKi use, of which 682 (72.5%) had nonmodifiable risk factors. Most common risk factors were current or former heavy smoking (62.8%, <em>n</em> = 591), obesity (28.1%, <em>n</em> = 264), hypercholesterolemia (21.5%, <em>n</em> = 202), and hypertension (18.8%, <em>n</em> = 177). Among patients without any risk factors at baseline (<em>n</em> = 173), 20.2% (<em>n</em> = 35) developed ≥1 risk factor during the following 12 months.</div></div><div><h3>Limitations</h3><div>Certain risk factors may be underreported.</div></div><div><h3>Conclusion</h3><div>Most CHE patients have risk factors limiting appropriateness of oral JAKi use. Health care providers should assess risk factors in their patients when choosing treatment for CHE.</div></div>","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"17 ","pages":"Pages 61-66"},"PeriodicalIF":0.0,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk of multiple primary cancers in patients with atypical fibroxanthoma/pleomorphic dermal sarcoma: A SEER analysis 非典型纤维黄瘤/真皮肉瘤患者罹患多种原发性癌症的风险：SEER 分析
JAAD International
Pub Date : 2024-09-02 DOI: 10.1016/j.jdin.2024.08.003
Vraj K. Shah BS , Rajiv I. Nijhawan MD
{"title":"Risk of multiple primary cancers in patients with atypical fibroxanthoma/pleomorphic dermal sarcoma: A SEER analysis","authors":"Vraj K. Shah BS ,&nbsp;Rajiv I. Nijhawan MD","doi":"10.1016/j.jdin.2024.08.003","DOIUrl":"10.1016/j.jdin.2024.08.003","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"17 ","pages":"Pages 51-52"},"PeriodicalIF":0.0,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patients with severe cutaneous adverse drug reactions have extremely high hair cortisol concentrations that do not correlate with the presence of depression 严重皮肤药物不良反应患者的毛发皮质醇浓度极高，但这与是否患有抑郁症无关
JAAD International
Pub Date : 2024-09-01 DOI: 10.1016/j.jdin.2024.07.027
Eddy M. Zitha MSc, MD , Ogheneochuko U. Oputu PhD , Sthomo Mevana ND, BTECH , Bukiwe Thwala MPH , Lovemore Mapahla MSc , Aneliswa Mpungose BCMP , Thuraya Isaacs MD, MFamMed, MMed , Jonny Peter MD, PhD , Rannakoe J. Lehloenya BSc, MD , Nonhlanhla P. Khumalo MD, PhD
{"title":"Patients with severe cutaneous adverse drug reactions have extremely high hair cortisol concentrations that do not correlate with the presence of depression","authors":"Eddy M. Zitha MSc, MD ,&nbsp;Ogheneochuko U. Oputu PhD ,&nbsp;Sthomo Mevana ND, BTECH ,&nbsp;Bukiwe Thwala MPH ,&nbsp;Lovemore Mapahla MSc ,&nbsp;Aneliswa Mpungose BCMP ,&nbsp;Thuraya Isaacs MD, MFamMed, MMed ,&nbsp;Jonny Peter MD, PhD ,&nbsp;Rannakoe J. Lehloenya BSc, MD ,&nbsp;Nonhlanhla P. Khumalo MD, PhD","doi":"10.1016/j.jdin.2024.07.027","DOIUrl":"10.1016/j.jdin.2024.07.027","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"17 ","pages":"Pages 163-166"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biopsy-proven diagnoses associated with monodactylous longitudinal nail plate change in a diverse patient population: A retrospective cross-sectional study 不同患者群体中与单足纵甲板变化相关的活检确诊：回顾性横断面研究
JAAD International
Pub Date : 2024-09-01 DOI: 10.1016/j.jdin.2024.08.005
Jeffrey N. Li MD, Ryan J. Scheinkman MEng, Brian W. Morrison MD
{"title":"Biopsy-proven diagnoses associated with monodactylous longitudinal nail plate change in a diverse patient population: A retrospective cross-sectional study","authors":"Jeffrey N. Li MD,&nbsp;Ryan J. Scheinkman MEng,&nbsp;Brian W. Morrison MD","doi":"10.1016/j.jdin.2024.08.005","DOIUrl":"10.1016/j.jdin.2024.08.005","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"17 ","pages":"Pages 58-60"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Social vulnerability and outcomes of head and neck cutaneous squamous cell carcinoma: A retrospective cohort study 头颈部皮肤鳞状细胞癌的社会脆弱性与预后：一项回顾性队列研究
JAAD International
Pub Date : 2024-08-31 DOI: 10.1016/j.jdin.2024.07.025
Lillian McCampbell BS , David Jun Fei-Zhang BA , Daniel Chelius MD , Ling-Lun Bob Hsia MD , Jeffrey Rastatter MD , Anthony Sheyn MD
{"title":"Social vulnerability and outcomes of head and neck cutaneous squamous cell carcinoma: A retrospective cohort study","authors":"Lillian McCampbell BS ,&nbsp;David Jun Fei-Zhang BA ,&nbsp;Daniel Chelius MD ,&nbsp;Ling-Lun Bob Hsia MD ,&nbsp;Jeffrey Rastatter MD ,&nbsp;Anthony Sheyn MD","doi":"10.1016/j.jdin.2024.07.025","DOIUrl":"10.1016/j.jdin.2024.07.025","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"17 ","pages":"Pages 48-50"},"PeriodicalIF":0.0,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human leukocyte antigen type does not improve risk stratification for SUNTRAC score in solid organ transplant recipients: A cohort study 人类白细胞抗原类型并不能改善实体器官移植受者 SUNTRAC 评分的风险分层：一项队列研究
JAAD International
Pub Date : 2024-08-31 DOI: 10.1016/j.jdin.2024.07.026
Dominique Mosley BS, MD , Christopher Madden BS , Jacqueline Ike MHS , Isabelle T. Smith , Sarah Grossarth MPH , Lee Wheless MD, PhD
{"title":"Human leukocyte antigen type does not improve risk stratification for SUNTRAC score in solid organ transplant recipients: A cohort study","authors":"Dominique Mosley BS, MD ,&nbsp;Christopher Madden BS ,&nbsp;Jacqueline Ike MHS ,&nbsp;Isabelle T. Smith ,&nbsp;Sarah Grossarth MPH ,&nbsp;Lee Wheless MD, PhD","doi":"10.1016/j.jdin.2024.07.026","DOIUrl":"10.1016/j.jdin.2024.07.026","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"17 ","pages":"Pages 80-81"},"PeriodicalIF":0.0,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142415956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sociodemographic factors have very little influence on adherence to topical drugs in patients with psoriasis 社会人口因素对银屑病患者坚持使用外用药物的影响很小
JAAD International
Pub Date : 2024-08-27 DOI: 10.1016/j.jdin.2024.07.013
Mathias Tiedemann Svendsen MD, PhD , Klaus Ejner Andersen MD, DMSc , Steven R. Feldman MD, PhD , Sören Möller MSc, PhD , Line Planck Kongstad MSc, PhD , Anna Mejldal MSc, PhD
{"title":"Sociodemographic factors have very little influence on adherence to topical drugs in patients with psoriasis","authors":"Mathias Tiedemann Svendsen MD, PhD ,&nbsp;Klaus Ejner Andersen MD, DMSc ,&nbsp;Steven R. Feldman MD, PhD ,&nbsp;Sören Möller MSc, PhD ,&nbsp;Line Planck Kongstad MSc, PhD ,&nbsp;Anna Mejldal MSc, PhD","doi":"10.1016/j.jdin.2024.07.013","DOIUrl":"10.1016/j.jdin.2024.07.013","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"17 ","pages":"Pages 160-162"},"PeriodicalIF":0.0,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improving efficacy and maintaining safety in the treatment of alopecia with low-dose oral minoxidil and spironolactone combination therapy: A retrospective review 用小剂量口服米诺地尔和螺内酯联合疗法治疗脱发，既能提高疗效，又能保证安全：回顾性研究
JAAD International
Pub Date : 2024-08-27 DOI: 10.1016/j.jdin.2024.07.023
Ambika Nohria BA , Deesha Desai BS , Michelle Sikora BS , Nnaemeka Anyanwu BA , Avrom Caplan MD , Jerry Shapiro MD , Kristen Lo Sicco MD
{"title":"Improving efficacy and maintaining safety in the treatment of alopecia with low-dose oral minoxidil and spironolactone combination therapy: A retrospective review","authors":"Ambika Nohria BA ,&nbsp;Deesha Desai BS ,&nbsp;Michelle Sikora BS ,&nbsp;Nnaemeka Anyanwu BA ,&nbsp;Avrom Caplan MD ,&nbsp;Jerry Shapiro MD ,&nbsp;Kristen Lo Sicco MD","doi":"10.1016/j.jdin.2024.07.023","DOIUrl":"10.1016/j.jdin.2024.07.023","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"17 ","pages":"Pages 24-26"},"PeriodicalIF":0.0,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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