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Assessment of The Therapeutic Role of Mangifera indica Leaves Extract in Diabetic Albino Rats 芒果叶提取物对糖尿病白化大鼠的治疗作用评价
Pub Date : 2022-10-09 DOI: 10.21608/eajbsz.2022.265796
Raga Maghfur, M. Shahat, M. Soliman
Because synthetic antidiabetic medications have undesirable side effects and are expensive, various studies on medicinal plants with hypoglycemic properties have continued looking for alternative ways to prevent and manage type 2 diabetes (T2D) that may be more efficient, cost-effective and secure. Efficient bioactive substances such as flavonoids, tannins, alkaloids, terpenoids, anthraquinones, saponins, cardiac glycosides, and steroids were discovered in Mangifera indica leaves (MIL). The study's goal was to evaluate the MIL's therapeutic potential in diabetic rats treated with streptozotocin (STZ). In the experiment, forty male adult albino rats were employed. The animals were separated into four groups, each with ten rats, and evaluated as follows: group 1 (healthy control, HC); group 2 (untreated diabetic, UD); group 3 (mango treated diabetic, MTD); and group 4 (mango treated, MT). After 8 weeks of MIL extract administration, blood samples were taken to assess several biochemical and hematological markers. The treatment of MIL extract in diabetic rats resulted in significant reductions in blood glucose, glycated hemoglobin (HbA-1c), and amylase enzyme activity. The levels of insulin, vitamin C, and vitamin E were significantly increased with MIL extract treatment. Further, the extract showed significant antihyperlipidemic activity and renoprotective and hepatoprotective effects in diabetic rats. These findings suggested a beneficial effect of MIL extract in the treatment of T2D associated with hyperlipidemia, and liver and kidney complications.
由于合成的抗糖尿病药物有不良的副作用,而且价格昂贵,对具有降糖特性的药用植物的各种研究一直在继续寻找预防和治疗2型糖尿病(T2D)的替代方法,这些方法可能更有效、更经济、更安全。在芒果叶中发现了黄酮类、单宁类、生物碱类、萜类、蒽醌类、皂苷类、心苷类和甾体等有效的生物活性物质。本研究的目的是评估MIL对链脲佐菌素(STZ)治疗糖尿病大鼠的治疗潜力。实验选用成年雄性白化大鼠40只。将动物分为4组,每组10只大鼠,评估如下:1组(健康对照,HC);2组(未经治疗的糖尿病,UD);3组(芒果治疗糖尿病,MTD);第4组(芒果处理,MT)。在给予MIL提取物8周后,取血样评估几种生化和血液学指标。MIL提取物对糖尿病大鼠的治疗导致血糖、糖化血红蛋白(HbA-1c)和淀粉酶活性显著降低。胰岛素、维生素C和维生素E的水平在MIL提取物治疗后显著升高。此外,该提取物对糖尿病大鼠具有显著的抗高脂血症活性和保护肾、保护肝的作用。这些发现表明,MIL提取物在治疗与高脂血症相关的T2D和肝肾并发症方面具有有益的作用。
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引用次数: 2
Bioindication of Beetles and Spiders for the Ecotoxicological Study of the Impact of Heavy Metals and their Interaction with Detoxification Enzymes 重金属对甲虫和蜘蛛的生态毒理学影响及其与解毒酶相互作用的生物指示
Pub Date : 2022-10-04 DOI: 10.21608/eajbsz.2022.263627
M. Mahmoud, Eman I. El Surtasi
become a great mean for a fast and accurate trend in the ecotoxicological study. Tenebrionid beetle ( Mesostena angustata ) and carnivorous spider ( Galeodes arabs ) were chosen as bioindicators to evaluate the industrial impact in El Sadat industrial region, Menofia, Egypt. Three categories of industries; light, medium, and heavy industries compared with the natural environment were selected. Bioaccumulation of heavy metal body burden and the interacted activity of detoxification enzymes: Acetylcholinesterase and Lactate Dehydrogenase were assessed in both species during four successive seasons. Results showed significant variations in the seasonal and spatial bioaccumulation of heavy metals in tested species. Summer was the highest season with heavy metal accumulation amongst the heavy industries, followed by the medium industries. That was confirmed later with the Metal pollution index. M. angustata was more susceptible to heavy metal accumulation than G. arabs. The major accumulated elements were; iron and zinc opposite to cadmium in both species . Consequently, the increased activity of both detoxifying enzymes revealed they are related to the bioaccumulation of heavy metals, particularly in the zone of heavy industries during the summer season. For confirmation, the significant positive relationship was between total accumulated heavy metals and detoxification enzyme activity.
成为生态毒理学研究快速、准确的重要手段。选取拟步甲(Mesostena angustata)和肉食性蜘蛛(Galeodes arabs)作为生物指标,对埃及Menofia El Sadat工业区的工业影响进行了评价。三大类产业;选取了与自然环境相比较的轻、中、重工业。连续4个季节对两种植物体内重金属负荷的生物积累和解毒酶乙酰胆碱酯酶和乳酸脱氢酶的相互作用活性进行了研究。结果表明,受试树种重金属的季节和空间生物积累存在显著差异。夏季是重工业重金属积累最多的季节,其次是中等工业。后来的金属污染指数证实了这一点。古石竹对重金属的积累比阿拉伯石竹更敏感。主要累积元素为;铁和锌在这两个物种中与镉相反。因此,两种解毒酶活性的增加表明它们与重金属的生物积累有关,特别是在夏季重工业区。重金属总积累量与解毒酶活性呈显著正相关。
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引用次数: 0
Therapeutic Potential of Adipose-Derived Mesenchymal Stem Cells (ADMSCs) with/without Taurine in Aluminum Chloride-Induced Alzheimer's Disease Rat Model 添加/不添加牛磺酸的脂肪源性间充质干细胞(ADMSCs)在氯化铝诱导的阿尔茨海默病大鼠模型中的治疗潜力
Pub Date : 2022-10-03 DOI: 10.21608/eajbsz.2022.262121
M. Hosney, Alaa Sakraan, Asaad, M., E. F., Emad Elzayat
Alzheimer's (AD) of characterized by its progression, neurobehavioral and neuro-pathological characteristics. Adipose-derived mesenchymal stem cells (ADMSCs) have previously proved a potential role in preventing the pathogenesis of several neurodegenerative disorders, so it is regarded as a promising new approach for AD regenerative therapy. Taurine was found to enhance stem cell activation and propagation, yielding a higher concentration of neural progenitors and stem cells, and reducing the number of activated microglia leading to down-regulated inflammation in vitro . The present study aimed to investigate the possible therapeutic potential of ADMSCs with/without taurine in treating the AD rat model. It was planned to include three successive phases: induction, withdrawal, and therapeutic phases. Fifty male Wistar rats were divided into two main groups: control (C) and AD model. Behavioral changes, as manifested by the T-maze experiment, had been recorded. β - amyloid levels had been measured in brain homogenate and serum by ELISA. Oxidative stress marker (MDA), brain and serum antioxidant enzyme activities (SOD, GSH, and CAT) as well serum acetylcholine esterase activity were spectrophotometrically determined. Pro-apoptotic (p53 and Bax) and anti-apoptotic (Bcl2) gene expression in the brain were evaluated using RT-qPCR. The histopathological alterations in brain tissues were also observed.
阿尔茨海默病(AD)以其进展、神经行为和神经病理特征为特征。脂肪源性间充质干细胞(ADMSCs)先前已被证明在预防几种神经退行性疾病的发病机制中具有潜在作用,因此它被认为是一种有希望的AD再生治疗新方法。牛磺酸被发现增强干细胞的激活和繁殖,产生更高浓度的神经祖细胞和干细胞,并减少激活的小胶质细胞的数量,导致体外炎症下调。本研究旨在探讨ADMSCs加牛磺酸/不加牛磺酸对AD大鼠模型的治疗潜力。计划包括三个连续的阶段:诱导、停药和治疗阶段。50只雄性Wistar大鼠分为两组:对照组(C)和AD模型组。在t型迷宫实验中表现出来的行为变化已经被记录下来。ELISA法测定大鼠脑匀浆及血清中β -淀粉样蛋白水平。用分光光度法测定氧化应激标志物(MDA)、脑和血清抗氧化酶(SOD、GSH和CAT)活性以及血清乙酰胆碱酯酶活性。采用RT-qPCR检测脑内促凋亡基因(p53、Bax)和抗凋亡基因(Bcl2)的表达。脑组织的组织病理学改变也被观察到。
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引用次数: 0
Melanomacrophage Centers: Comparative Histological Insights among Three Reptilian Species 黑素巨噬细胞中心:三种爬行动物的比较组织学见解
Pub Date : 2022-09-27 DOI: 10.21608/eajbsz.2022.260921
R. Ahmed
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引用次数: 0
House Crow Habitats and Habits. 家鸦的栖息地和习性。
Pub Date : 2022-09-04 DOI: 10.21608/eajbsz.2022.259410
S. m, Eldnasory, A., Anany, E.
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引用次数: 0
The Toxic Influence of The Fungicide Remilitine and Chromium Ion on Reproduction of Earthworm, Eisnia feditia 杀菌剂Remilitine和铬离子对蚯蚓繁殖的毒性影响
Pub Date : 2022-09-02 DOI: 10.21608/eajbsz.2022.259407
Ali Ali, A. Farag
In The present study, The E.fetida has maintained in a glass aquaria on a culture media as described by Organization for Economic Cooperation and
在本研究中,费迪达E.fetida在一个玻璃水族箱中,用经济合作组织描述的一种培养基饲养
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引用次数: 0
Effects of Physico-Chemical Parameters on The Efficiency of Stations and Water Lifting Pumps of Al-Salam Canal, Egypt 理化参数对埃及Al-Salam运河站水泵效率的影响
Pub Date : 2022-08-29 DOI: 10.21608/eajbsz.2022.258263
M. El-Kady, A. Hasan, A. M., M. Abuzeid
----------------------Keywords have a positive impact on the expansion of agricultural production, redistribution of the Egyptian population through resettlement, increase in employment and establishment of new rural communities. However, it may have some negative impacts on the waterways in relation to pollution of water that may have a serious effect on the operation and maintenance of the lifting pumps. In order to keep the project sustainable and protect the distribution system including the water lifting pumps, monitoring the quality of surface water in the main drains (Faraskur Drain, Sirw Drain and Bahr Hadous) and Al-Salam Canal was determined within 14 locations along Al-Salam network system during the summer season (2018). The present results indicated that it is difficult to make an overall assessment of the degree of contamination of the surface water along Al-Salam network system because there is considerable spatial variability between locations. Also, the present study showed locations that containing a high level of TSS, TDS, EC, BOD, COD, cations, anions, ammonia, heavy metals and oil and grease were displayed quite directly or indirectly corrosive to all the components of water lifting pump system.
----------------------关键词对扩大农业生产、通过安置重新分配埃及人口、增加就业和建立新农村社区有积极影响。然而,它可能会对水道产生一些负面影响,涉及水污染,可能会对提升泵的操作和维护产生严重影响。为了保持项目的可持续性并保护包括升水泵在内的分配系统,在夏季(2018年)确定了沿Al-Salam网络系统的14个地点监测主要排水沟(Faraskur排水沟、Sirw排水沟和Bahr haous)和Al-Salam运河的地表水质量。目前的结果表明,由于地点之间存在相当大的空间变异性,很难对Al-Salam网络系统地表水的污染程度进行全面评估。此外,研究还表明,TSS、TDS、EC、BOD、COD、阳离子、阴离子、氨、重金属、油脂等污染物含量较高的部位对升水泵系统各部件具有直接或间接的腐蚀性。
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引用次数: 0
Effect of Microwave Energy on Some Stored Product Mites 微波能对某些储存品螨的影响
Pub Date : 2022-08-24 DOI: 10.21608/eajbsz.2022.257249
E. Ayad, O. Roshdy, Hosnia A. Afifi
siro L., Caloglyphus berlesei (Michael) and Carpoglyphus lactis (L.). The results indicated that the mortality increased gradually when exposure time and power increased. The mortality rate for all stages of mites in the untreated treatment is zero. The mortality in C. lactis was higher than in other mite species. The mortality experiments were conducted with an exposure time ranging from 120–300 sec. at the powers of 180, 300 and 450 W. Acarus siro , C. berlesei and C. lactis larvae died at a higher rate than protonymph and adults. The protonymph died at a higher rate than adults when exposed to the same microwave energy. Mortality percent for larvae of A. siro was 94% using microwave energy at 180 W for 300 sec. The mortality of A. siro adults was 94% at 450W for 120 sec., and the mortality of C. berlesei adults was 82% at 450W for 240 sec. While the mortality of C. lactis larvae was 96% at 450W for 120 sec. These results indicated that the exposure time is more effect on acarid mites than power energy.
siro L., Caloglyphus berlesei (Michael)和Carpoglyphus lactis (L.)。结果表明,随着暴露时间和功率的增加,死亡率逐渐升高。在未经治疗的情况下,所有阶段螨虫的死亡率为零。乳螨的死亡率高于其他螨种。在180、300和450瓦的功率下,在120 ~ 300秒的时间内进行死亡实验。绿僵螨、白僵螨和乳僵螨幼虫的死亡率高于原淋巴和成虫。当暴露在相同的微波能量下时,原淋巴细胞的死亡率高于成人。在180 W微波照射300 s下,银粉螨幼虫死亡率为94%,450W微波照射120 s下银粉螨成虫死亡率为94%,贝氏银粉螨成虫死亡率为82%,而乳粉螨成虫死亡率为96%。结果表明,微波照射时间对银粉螨的影响大于功率。
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引用次数: 1
Milk and Dairy Products: Good or Bad for Human Health 牛奶和奶制品:对人体健康是好是坏
Pub Date : 2022-08-12 DOI: 10.21608/eajbsz.2022.253340
Athraa H. Ali
Numerous macro- and micronutrients are thought to be present in milk. It has a healthy mix of protein, fat, carbs, and other nutrients that support good nutrition and advantageous health effects. When compared to the milk of other animals, goat milk is thought to be superior in terms of a host of health advantages and a lower risk of allergy. To improve the quality and shelf life of goat milk and its products, a number of processing procedures have been used, including pasteurization, ultrafiltration, microfiltration, and ultrasound. A wide variety of dairy products are made with goat milk, including yogurt and cheese, Marketable products made by the use of cutting-edge processing methods include goat milk powder, fermented milk, and others. It has been demonstrated that goats raised on pasture-based feeding methods produce milk with a higher level of nutrients than their counterparts. Potential bioactive components found in goat milk support the maintenance of the body's normal metabolism and function. This review sheds light on the essential nutritional components and bioactive elements found in goat milk, as well as their potential contribution to the creation of diverse functional foods employing various processing techniques. In comparison to other milk options.
人们认为牛奶中含有大量的宏量营养素和微量营养素。它含有蛋白质、脂肪、碳水化合物和其他营养物质的健康组合,这些营养物质支持良好的营养和有益的健康效果。与其他动物的奶相比,羊奶被认为在许多健康优势和较低的过敏风险方面更胜一筹。为了提高羊奶及其产品的质量和保质期,人们使用了许多加工方法,包括巴氏杀菌、超滤、微滤和超声波。各种各样的乳制品都是用山羊奶制成的,包括酸奶和奶酪,市场上使用尖端加工方法制成的产品包括山羊奶粉、发酵奶等。已经证明,以牧场为基础的喂养方法饲养的山羊所产的奶比同类的营养水平更高。在羊奶中发现的潜在生物活性成分支持维持身体的正常代谢和功能。本文综述了羊奶中的基本营养成分和生物活性元素,以及它们对利用各种加工技术创造各种功能食品的潜在贡献。与其他牛奶相比。
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引用次数: 2
Study on Toxic Effects of Lead Acetate on Haematological Parameters of Adult Albino Rats and The Role of Mesenchymal Stem Cells and Flax Seeds Oil as Therapeutic Agents 醋酸铅对成年白化病大鼠血液学指标的毒性作用及间充质干细胞和亚麻籽油治疗作用的研究
Pub Date : 2022-08-10 DOI: 10.21608/eajbsz.2022.253274
A. EL-Shater, Rana A. Ali, M. Fawy
{"title":"Study on Toxic Effects of Lead Acetate on Haematological Parameters of Adult Albino Rats and The Role of Mesenchymal Stem Cells and Flax Seeds Oil as Therapeutic Agents","authors":"A. EL-Shater, Rana A. Ali, M. Fawy","doi":"10.21608/eajbsz.2022.253274","DOIUrl":"https://doi.org/10.21608/eajbsz.2022.253274","url":null,"abstract":"","PeriodicalId":34551,"journal":{"name":"Egyptian Academic Journal of Biological Sciences B Zoology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78233127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
期刊
Egyptian Academic Journal of Biological Sciences B Zoology
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