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Thermodilution assessment of vasoreactivity and microvascular function in the absence of obstructive coronary artery disease 无阻塞性冠状动脉疾病时血管反应性和微血管功能的热稀释评估
Q2 Medicine Pub Date : 2023-06-07 DOI: 10.24875/recice.m23000376
Pau Federico Zaragoza, T. Castelló Viguer, Luis Martínez Ortiz de Urbina, Ana Planas del Viejo, E. Peris Domingo, F. Pomar Domingo
Introduction and objectives: Invasive diagnosis of vasoreactivity and microvascular function may be useful to optimize the management of patients with signs and/or symptoms of myocardial ischemia in the absence of significant coronary stenosis (INOCA). We analyzed the prevalence of the different endotypes, as well as the concordance between 2 diagnostic methods based on ther-modilution assessment. Methods: We prospectively included 60 patients with INOCA who underwent a vasoreactivity test with intracoronary acetylcholine, and measurement of absolute coronary blood flow (Q) and minimum microvascular resistance (R) using continuous thermodilution assessment. Finally, calculations of the coronary flow reserve (CFR) and index of microcirculatory resistance index (IMR) were made using the bolus thermodilution method considering CFR < 2 and MRI ≥ 25 as established pathological cut-off values. Results: The invasive functional diagnostic procedure allowed patients to be categorized into 4 subgroups: microvascular dysfunction (40%), epicardial vasospasm (17%), mixed disorder (20%), and normal study (23%). No correlation was seen between the Q and the CFR. Using ROC curves, an R > 435 UW was estimated as the optimal cut-off value to identify patients with IMR ≥ 25 with an area under the curve of 0.67 (95%CI, 0.51-0.82; P = .04). Conclusions: The invasive study of vasoreactivity and microcirculation was feasible and safe. Prevalence of vasospasm and microvascular dysfunction in patients with INOCA was high. The CFR/MRI/Q combined study allowed us to unmask a subtype of microvascular dysfunction characterized by an abnormally high coronary flow at baseline. The concordance seen between the microvascular resistance obtained by continuous thermodilution measurements and the reference method was low so future studies are justified to determine the usefulness of this technique.
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引用次数: 0
Drug-eluting balloon angioplasty for bifurcated chronic total coronary occlusion 药物洗脱球囊成形术治疗慢性冠脉分叉性全闭塞
Q2 Medicine Pub Date : 2023-06-02 DOI: 10.24875/recice.m23000390
Marcel Alméndarez, Rut Álvarez-Velasco, Alberto Alperi Garcia, P. Avanzas, Cesar Morís de la Tassa, and Isaac Pascual
This is the case of a 67-year-old woman admitted due to a 6-month history of exertional angina. Stress echocardiography showed severe anterior wall ischemia. The patient was referred for coronary angiography that revealed the presence of a chronic total coronary occlusion of the proximal left anterior descending coronary artery (LAD) immediately before the bifurcation with the first diagonal branch (D1) from the septal collaterals of the right coronary artery (figure 1A, video 1 of the supplementary data). The patient signed the written informed consent, and a chronic total coronary occlusion recanalization was performed 6 months after the index angiography.
这是一例67岁的女性,因6个月的劳累性心绞痛病史而入院。超声心动图显示前壁严重缺血。患者接受冠状动脉造影检查,发现左前降支(LAD)近端存在慢性全冠状动脉闭塞,就在右冠状动脉间隔侧支的第一对角分支(D1)分叉之前(图1A,补充数据的视频1)。患者签署书面知情同意书,在指数血管造影6个月后行慢性全冠状动脉闭塞再通术。
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引用次数: 0
Design of the ROLLERCOASTR trial: rotational atherectomy, lithotripsy or laser for the management of calcified coronary stenosis ROLLERCOASTR试验的设计:旋磨、碎石或激光治疗钙化性冠状动脉狭窄
Q2 Medicine Pub Date : 2023-05-22 DOI: 10.24875/recice.m23000381
A. Jurado-Román, A. Gómez-Menchero, I. Amat-Santos, J. Caballero-Borrego, S. Ojeda, R. Ocaranza-Sanchez, S. Jiménez-Valero, G. Galeote, and Raúl Moreno
Introduction and objectives: Coronary calcification is one of the leading factors that affect negatively the safety and effectiveness of percutaneous coronary intervention. Several calcium modification techniques exist. However, there is a lack of randomized evidence on the therapy of choice in this scenario. Methods: The ROLLERCOASTR is a prospective, multicenter, randomized clinical trial designed to compare the safety and efficacy profile of 3 plaque modification techniques in the moderate-to-severe coronary calcification setting: rotational atherectomy (RA), excimer laser coronary angioplasty (ELCA), and intravascular lithotripsy (IVL). The study primary endpoint is stent expansion evaluated by optical coherence tomography. An intention-to-treat analysis will be conducted with an alpha coefficient of 0.05 between the reference group (RA) and the remaining 2 groups (ELCA and IVL). An analysis of the study primary endpoint per protocol will be conducted for consistency purposes. If the non-inferiority hypothesis is confirmed, a superiority 2-sided analysis will be conducted. Both the clinical events committee and the independent core laboratory will be blinded to the treatment arm. Assuming an α error of 0.05, an β error of 0.2 (80% power), a margin of irrelevance ( ε ) of 7, and losses of 10% due to measurement difficulty or impossibility to complete the intervention, we estimate a sample size of 56 cases per group. The study secondary endpoints are device success, procedural success, crossover rate among the different techniques used, and the occurrence of major adverse cardiovascular events at 1-year follow-up. Conclusions: The ROLLERCOASTR trial will evaluate and compare the safety and effectiveness of 3 plaque modification techniques: RA, ELCA, and IVL in patients with calcified coronary stenosis. This trial was registered at clinicaltrials.gov with identifier NCT04181268.
引言和目的:冠状动脉钙化是影响经皮冠状动脉介入治疗安全性和有效性的主要因素之一。存在几种钙改性技术。然而,在这种情况下,缺乏关于选择治疗的随机证据。方法:ROLLERCOASTR是一项前瞻性、多中心、随机临床试验,旨在比较3种斑块修饰技术在中重度冠状动脉钙化环境中的安全性和有效性:旋磨术(RA)、准分子激光冠状动脉成形术(ELCA)和血管内碎石术(IVL)。研究的主要终点是通过光学相干断层扫描评估支架扩张。将在参考组(RA)和其余2组(ELCA和IVL)之间进行意向治疗分析,α系数为0.05。出于一致性目的,将根据方案对研究主要终点进行分析。如果非劣效性假设得到证实,则将进行优效性双侧分析。临床事件委员会和独立核心实验室都将对治疗部门视而不见。假设α误差为0.05,β误差为0.2(80%的幂),不相关裕度(ε)为7,由于测量困难或无法完成干预而损失10%,我们估计每组样本量为56例。研究的次要终点是器械成功率、手术成功率、所用不同技术的交叉率以及1年随访中主要心血管不良事件的发生率。结论:ROLLERCOASTR试验将评估和比较3种斑块修饰技术:RA、ELCA和IVL在钙化性冠状动脉狭窄患者中的安全性和有效性。该试验在clinicaltrials.gov上注册,标识符为NCT04181268。
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引用次数: 0
The mystery of the Dragon�s tail solved by 3D reconstruction 龙之谜�三维重建求解s尾
Q2 Medicine Pub Date : 2023-05-22 DOI: 10.24875/recice.m23000385
S. Santos-Martínez, Miguel Leiva-Gordillo, R. García-Belenguer, Paula Tejedor-Viñuela, and Pedro Morillas-Blasco
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引用次数: 0
Transcatheter closure of aorto-left atrial fistula 经导管主动脉-左房瘘闭合术
Q2 Medicine Pub Date : 2023-05-17 DOI: 10.24875/recice.m23000387
M. Tamargo, J. Elízaga, and Francisco Fernández-Avilés
1. Mamas MA, Fraser DG, Ratib K, et al. Minimising radial injury: prevention is better than cure. EuroIntervention. 2014;10:824-832. 2. Hausenloy DJ, Kharbanda RK, Møller UK, et al. Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial. Lancet. 2019;394(10207):1415-1424. 3. Kume T, Akasaka T, Kawamoto T, et al. Assessment of coronary intimamedia thickness by optical coherence tomography: comparison with intravascular ultrasound. Circ J. 2005;69:903-907. 4. Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium. Circulation. 1986;74:1124-1136.
1. Mamas MA, Fraser DG, Ratib K等。减少桡骨损伤:预防胜于治疗。EuroIntervention。2014; 10:824 - 832。2. 王晓明,王晓明,王晓明,等。远程缺血调节对急性心肌梗死患者临床结局的影响(cdi -2/ERIC-PPCI):一项单盲随机对照试验柳叶刀》。2019;394(10207):1415 - 1424。3.Kume T, Akasaka T, Kawamoto T等。光学相干断层扫描评估冠状动脉内膜厚度:与血管内超声的比较。中华医学杂志。2005;69:903-907。4. 默里CE,詹宁斯RB,雷默KA。缺血预处理:缺血心肌致死性细胞损伤的延迟。循环。1986;74:1124 - 1136。
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引用次数: 0
Syphilitic aortitis as a rare cause of coronary ostial stenosis 梅毒性大动脉炎是冠状动脉口狭窄的罕见原因
Q2 Medicine Pub Date : 2023-05-11 DOI: 10.24875/recice.m23000375
Rui Flores, F. Mané, C. Braga, and Cátia Oliveira
1. Woo EJ, Ogilvie RA, Krueger VS, Lundin M, Williams DM. Iliac vein compression syndrome from anterior perforation of a pedicle screw. J Surg Case Rep. 2016;2016:rjw003. 2. Cannon KA, Badiee J, Wallace JD, et al. The prevalence of chronic deep venous thrombosis in trauma: Implications for hospitals and patients. J Trauma Acute Care Surg. 2018;84:170-174. 3. Galea R, Roten L, Siontis GCM, Brugger N, Windecker S, Räber L. Percutaneous left atrial appendage closure with superior vascular access. EuroIntervention. 2022;18:e695-e696. 4. Zare P, Rechani L, Smithson S. Left atrial appendage closure device implantation via transhepatic vascular access: a case report. Eur Heart J Case Rep. 2020;4:1-5. CONFLICTS OF INTEREST
1. Woo EJ, Ogilvie RA, Krueger VS, Lundin M, Williams DM.椎弓根螺钉前穿孔引起的髂静脉压迫综合征。中华外科杂志2016;2016:rjw003。2. Cannon KA, Badiee J, Wallace JD,等。创伤中慢性深静脉血栓的流行:对医院和患者的意义。中华创伤急症外科杂志,2018;34(4):391 - 391。3.王晓明,王晓明,王晓明,等。经皮左心耳闭合术。EuroIntervention。2022; 18: e695-e696。4. Zare P, Rechani L, Smithson S.经肝血管通道左心耳封闭装置植入一例报告。欧洲心脏杂志,2020;4:1-5。利益冲突
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引用次数: 0
The MANTA vascular closure device in transfemoral TAVI: a real-world cohort MANTA血管闭合装置在经股TAVI中的应用:一个真实世界的队列
Q2 Medicine Pub Date : 2023-05-11 DOI: 10.24875/recice.m23000380
Sofia Martinho, E. Jorge, V. Marinho, R. Baptista, Marco Costa, and Lino Gonçalves
Introduction and objectives: Transcatheter aortic valve implantation (TAVI) is an established treatment option for patients with symptomatic severe aortic stenosis often performed via transfemoral access route (TF-TAVI). Therefore, successful closure of large-bore access sites is essential. This study aims to investigate the safety and effectiveness of the MANTA (Teleflex/Essential Medical, United States) vascular closure device (VCD) in patients undergoing TF-TAVI in an unselected and consecutive cohort of patients. Methods: We conducted a single-center, observational study of 245 consecutive patients undergoing TF-TAVI in whom the arterial large-bore femoral access was closed with a MANTA device from March 2020 through February 2022. The primary efficacy outcome measure was the rate of VCD failure according to the VARC-3 definition. Results: Successful closure of the large-bore access site occurred in 92.2% of the patients (n = 226). According to the VARC-3 definition, no major vascular or bleeding complications related to the plug-based VCD were reported. Patients with failed VCDs (7.8%) had significantly smaller minimal femoral artery diameters (6.6 ± 1.1 mm vs 7.6 ± 1.4 mm; P = .005) and consequently, significant higher sheath-to-femoral artery diameter ratios (0.78 ± 0.16 vs 0.69 ± 0.15; P = .019). No other inter-group differences were found. Conclusions: In this single-center, real-world, unselected large cohort of consecutive patients treated with TF-TAVI, a plug-based VCD for large-bore arteriotomy closure turned out effective and safe, and enabled arterial access-site management with a low rate of complications.
引言和目的:经导管主动脉瓣植入术(TAVI)是症状性严重主动脉瓣狭窄患者的一种既定治疗选择,通常通过经股动脉途径(TF-TAVI)进行。因此,成功关闭大口径接入点至关重要。本研究旨在调查MANTA(美国Teleflex/Essential Medical)血管闭合装置(VCD)在未经选择的连续患者队列中接受TF-TAVI的患者中的安全性和有效性。方法:我们对245名连续接受TF-TAVI的患者进行了一项单中心观察性研究,这些患者在2020年3月至2022年2月期间使用MANTA装置关闭了动脉大径股动脉通路。根据VARC-3的定义,主要疗效指标是VCD失败率。结果:92.2%的患者(n=226)成功闭合了大口径进入部位。根据VARC-3的定义,没有报告与基于栓塞的VCD相关的主要血管或出血并发症。VCD失败的患者(7.8%)的最小股动脉直径显著较小(6.6±1.1 mm vs 7.6±1.4 mm;P=0.005),因此鞘管与股动脉的直径比显著较高(0.78±0.16 vs 0.69±0.15;P=0.019)。未发现其他组间差异。结论:在这个由TF-TAVI治疗的单中心、真实世界、未经选择的连续大队列患者中,一种用于大口径动脉切开术闭合的基于栓塞的VCD是有效和安全的,并且能够以较低的并发症发生率管理动脉入路部位。
{"title":"The MANTA vascular closure device in transfemoral TAVI: a real-world cohort","authors":"Sofia Martinho, E. Jorge, V. Marinho, R. Baptista, Marco Costa, and Lino Gonçalves","doi":"10.24875/recice.m23000380","DOIUrl":"https://doi.org/10.24875/recice.m23000380","url":null,"abstract":"Introduction and objectives: Transcatheter aortic valve implantation (TAVI) is an established treatment option for patients with symptomatic severe aortic stenosis often performed via transfemoral access route (TF-TAVI). Therefore, successful closure of large-bore access sites is essential. This study aims to investigate the safety and effectiveness of the MANTA (Teleflex/Essential Medical, United States) vascular closure device (VCD) in patients undergoing TF-TAVI in an unselected and consecutive cohort of patients. Methods: We conducted a single-center, observational study of 245 consecutive patients undergoing TF-TAVI in whom the arterial large-bore femoral access was closed with a MANTA device from March 2020 through February 2022. The primary efficacy outcome measure was the rate of VCD failure according to the VARC-3 definition. Results: Successful closure of the large-bore access site occurred in 92.2% of the patients (n = 226). According to the VARC-3 definition, no major vascular or bleeding complications related to the plug-based VCD were reported. Patients with failed VCDs (7.8%) had significantly smaller minimal femoral artery diameters (6.6 ± 1.1 mm vs 7.6 ± 1.4 mm; P = .005) and consequently, significant higher sheath-to-femoral artery diameter ratios (0.78 ± 0.16 vs 0.69 ± 0.15; P = .019). No other inter-group differences were found. Conclusions: In this single-center, real-world, unselected large cohort of consecutive patients treated with TF-TAVI, a plug-based VCD for large-bore arteriotomy closure turned out effective and safe, and enabled arterial access-site management with a low rate of complications.","PeriodicalId":34613,"journal":{"name":"REC Interventional Cardiology English Ed","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42463556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intracoronary fibrinolysis as a bailout strategy for massive thrombotic catastrophe. Case resolution 冠状动脉内纤溶作为大规模血栓形成灾难的救助策略。案例解析
Q2 Medicine Pub Date : 2023-05-10 DOI: 10.24875/recice.m22000306
Rui Flores, João Costa, Carlos Braga, Catarina Vieira, and, Catarina Quina-Rodrigues
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引用次数: 0
New TAVI technique for difficult valve crossing 新TAVI技术解决阀门交叉困难
Q2 Medicine Pub Date : 2023-05-04 DOI: 10.24875/recice.m23000379
J. M. T. Torre Hernández, Gabriela Veiga Fernández, S. Barrera, Fermín Sainz Laso, Daehyun Lee, and Tamara García Camarero
,
{"title":"New TAVI technique for difficult valve crossing","authors":"J. M. T. Torre Hernández, Gabriela Veiga Fernández, S. Barrera, Fermín Sainz Laso, Daehyun Lee, and Tamara García Camarero","doi":"10.24875/recice.m23000379","DOIUrl":"https://doi.org/10.24875/recice.m23000379","url":null,"abstract":",","PeriodicalId":34613,"journal":{"name":"REC Interventional Cardiology English Ed","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44370192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dosimetric parameters in congenital cardiac catheterizations in Spain: the GTH-SECPCC Radcong-21 multicenter registry 西班牙先天性心脏导管的剂量参数:GTH-SECPCC Radcong-21多中心注册
Q2 Medicine Pub Date : 2023-05-04 DOI: 10.24875/recice.m23000372
F. Rueda Núñez, C. Abelleira Pardeiro, B. Insa Albert, M. Álvarez-Fuente, Vanesa Balboa Barreiro, F. Ballesteros Tejerizo, P. Betrián-Blasco, Félix Coserría Sánchez, Juana María Espín López, Luis Fernández González, Dolores Herrera Linde, M. R. Romero Moreno, F. Sarnago Cebada, R. Sanz-Ruiz, and Juan Ignacio Zabala Argüelles
Introduction and objectives: The results of the Radcong-21 Registry of the Spanish Society of Pediatric Cardiology and Congenital Heart Disease Working Group on Hemodynamics are described to analyze data, establish updated reference parameters, and compare them to other registries. Methods: Retrospective, cross-sectional, observational, multicenter registry of patients with congenital heart disease undergoing cardiac catheterization in 2021. Each cath lab sent the last 100 cases performed prior to January 2022. A descriptive analysis was conducted of anthropomorphic variables, procedural (grouped by type and radiation exposure categories [REC]) and technical characteristics, and dosimetric parameters with additional review of all values outside the 95%CI of the median. Results: A total of 1090 procedures performed in 11 cath lab of 10 hospital centers were analyzed. Age distribution: 22.8% < 1 year, 60.7% between 1-18 years, and 16.4% > 18 years. In dose area product (DAP)/Kg and DAP/Kg/fluoroscopy, the distribution was very similar regardless of the type of cath lab as is the case with most pediatric patients in terms of age, weight, and REC group. The DAP/Kg was higher in the REC I and III groups compared to other countries with registries and improvement programs in this area (78% and 8,3%, respectively). Conclusions: Representative data of dosimetric parameters by age and procedures in congenital cardiac catheterizations were obtained in Spain back in 2021. DAP/Kg is the parameter with the lowest dispersion in the sample. There is room for improvement compared to other countries with optimization programs in this area.
{"title":"Dosimetric parameters in congenital cardiac catheterizations in Spain: the GTH-SECPCC Radcong-21 multicenter registry","authors":"F. Rueda Núñez, C. Abelleira Pardeiro, B. Insa Albert, M. Álvarez-Fuente, Vanesa Balboa Barreiro, F. Ballesteros Tejerizo, P. Betrián-Blasco, Félix Coserría Sánchez, Juana María Espín López, Luis Fernández González, Dolores Herrera Linde, M. R. Romero Moreno, F. Sarnago Cebada, R. Sanz-Ruiz, and Juan Ignacio Zabala Argüelles","doi":"10.24875/recice.m23000372","DOIUrl":"https://doi.org/10.24875/recice.m23000372","url":null,"abstract":"Introduction and objectives: The results of the Radcong-21 Registry of the Spanish Society of Pediatric Cardiology and Congenital Heart Disease Working Group on Hemodynamics are described to analyze data, establish updated reference parameters, and compare them to other registries. Methods: Retrospective, cross-sectional, observational, multicenter registry of patients with congenital heart disease undergoing cardiac catheterization in 2021. Each cath lab sent the last 100 cases performed prior to January 2022. A descriptive analysis was conducted of anthropomorphic variables, procedural (grouped by type and radiation exposure categories [REC]) and technical characteristics, and dosimetric parameters with additional review of all values outside the 95%CI of the median. Results: A total of 1090 procedures performed in 11 cath lab of 10 hospital centers were analyzed. Age distribution: 22.8% < 1 year, 60.7% between 1-18 years, and 16.4% > 18 years. In dose area product (DAP)/Kg and DAP/Kg/fluoroscopy, the distribution was very similar regardless of the type of cath lab as is the case with most pediatric patients in terms of age, weight, and REC group. The DAP/Kg was higher in the REC I and III groups compared to other countries with registries and improvement programs in this area (78% and 8,3%, respectively). Conclusions: Representative data of dosimetric parameters by age and procedures in congenital cardiac catheterizations were obtained in Spain back in 2021. DAP/Kg is the parameter with the lowest dispersion in the sample. There is room for improvement compared to other countries with optimization programs in this area.","PeriodicalId":34613,"journal":{"name":"REC Interventional Cardiology English Ed","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47454216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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REC Interventional Cardiology English Ed
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