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Impact of time of intervention in patients with NSTEMI. The IMPACT-TIMING-GO trial design 干预时间对非stemi患者的影响。冲击-定时- go试验设计
Q2 Medicine Pub Date : 2022-10-24 DOI: 10.24875/recice.m22000338
F. Díez-Delhoyo, P. Díez-Villanueva, M. T. López Lluva, M. Abellás, I. Amat-Santos, P. Bazal-Chacón, A. Carrasquer, M. Corbí, D. Escribano, Ane Elorriaga, S. García-Blas, T. Giralt-Borrell, A. Jurado-Román, I. Llaó, L. Matute-Blanco, Martín Negreira-Caamaño, Lucía Pérez-Cebey, R. Rivera-López, Carolina Robles‐Gamboa, P. Salinas, Fernando José Torres Mezcúa, Iván Olavarri-Miguel, Jessica Vaquero-Luna, and, P. Cepas-Guillen
Introduction and objectives: The optimal time to perform a diagnostic coronary angiography in patients admitted due to non-ST-seg- ment elevation acute coronary syndrome (NSTEACS) and start pretreatment with dual antiplatelet therapy is controversial. Our study aims to identify the current diagnostic and therapeutic approach, and clinical progression of patients with NSTEACS in our country. Methods: The IMPACT-TIMING-GO trial (Impact of time of intervention in patients with myocardial infarction with non-ST segment elevation. Management and outcomes) is a national, observational, prospective, and multicenter registry that will include consecutive patients from 24 Spanish centers with a clinical diagnosis of NSTEACS treated with diagnostic coronary angiography and with present unstable or causal atherosclerotic coronary artery disease. The study primary endpoint is to assess the level of compliance to clinical practice guidelines in patients admitted due to NSTEACS undergoing coronary angiography in Spain, describe the use of antithrombotic treatment prior to cardiac catheterization, and register the time elapsed until it is performed. Major adverse cardiovascular events will also be described like all-cause mortality, non-fatal myocardial infarction and non-fatal stroke, and the rate of major bleeding according to the BARC (Bleeding Academic Research Consortium) scale at 1- and 3-year follow-up. Results: This study will provide more information on the impact of different early management strategies in patients admitted with NSTEACS in Spain, and the degree of implementation of current recommendations into the routine clinical practice. It will also provide information on these patients’ baseline and clinical characteristics. ManaGe- la incidencia de hemorragia mayor según la escala BARC (Bleeding Academic Research Consortium) durante el seguimiento a 1 y 3 años. Resultados: Este registro permitirá mejorar el conocimiento en relación con el abordaje terapéutico inicial en pacientes que ingresan por SCASEST en España. Contribuirá a conocer sus características basales y su evolución clínica, así como el grado de adherencia y cumplimiento de las recomendaciones de las que se dispone actualmente. Conclusiones: Se trata del primer estudio prospectivo realizado en España que permitirá conocer las estrategias terapéuticas iniciales, tanto farmacológicas como intervencionistas, que se realizan en nuestro país en pacientes con SCASEST tras la publicación de las guías europeas de 2020, y la evolución clínica de estos pacientes a corto y largo plazo. Conclusions: This is the first prospective study conducted in Spain that will be reporting on the early therapeutic strategies—both pharmacological and interventional—implemented in our country in patients with NSTEACS after the publication of the 2020 European guidelines, and on the clinical short- and long-term outcomes of these patients. sin
引言和目的:对因非ST段抬高型急性冠状动脉综合征(NSTEACS)入院的患者进行诊断性冠状动脉造影并开始双重抗血小板治疗的最佳时间存在争议。我们的研究旨在确定我国NSTEACS患者的当前诊断和治疗方法以及临床进展。方法:IMPACT-TIMING-GO试验(非ST段抬高心肌梗死患者干预时间的影响。管理和结果)是一项全国性、观察性、前瞻性、,以及多中心注册,将包括来自24个西班牙中心的连续患者,这些患者临床诊断为NSTEACS,接受诊断性冠状动脉造影治疗,并患有不稳定或因果性动脉粥样硬化性冠状动脉疾病。研究的主要终点是评估在西班牙接受冠状动脉造影的NSTEACS患者对临床实践指南的依从性水平,描述心导管插入术前抗血栓治疗的使用情况,并记录进行治疗前的时间。主要心血管不良事件也将被描述为全因死亡率、非致命性心肌梗死和非致命性中风,以及根据BARC(出血学术研究联盟)量表在1年和3年随访中的大出血率。结果:这项研究将提供更多关于西班牙NSTEACS患者不同早期管理策略的影响,以及当前建议在常规临床实践中的实施程度的信息。它还将提供有关这些患者的基线和临床特征的信息。ManaGe-la incidencia de hemorragia市长según la escala BARC(出血学术研究联合会)在1到3年的时间里。结果:Este registro peritirámejorar el conocimiento en relación con el abordaje terapéutico inicial en pacientes que incresan por SCASEST en España。控制基础的特征和演变,作为对实际情况的遵守和建议的补充。结论:在2020年欧洲公共卫生研究所(SCASEST)的基础上,在西班牙进行了初步的前瞻性研究。结论:这是西班牙进行的第一项前瞻性研究,将报告2020年欧洲指南发布后,我国对NSTEACS患者实施的早期治疗策略,包括药物和干预策略,以及这些患者的临床短期和长期结果。罪
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引用次数: 1
Ischemic postconditioning fails to reduce infarct size in pig models of intermediate and prolonged ischemia 在中度和长期缺血的猪模型中,缺血后处理不能减少梗死面积
Q2 Medicine Pub Date : 2022-10-19 DOI: 10.24875/recice.m22000333
J. Nuche, Carlos Galán‐Arriola, R. Fernández-Jiménez, María Isabel Higuero Verdejo, Victoria I. González Pastor, Ravi Vazirani, Arturo Lanaspa, María Anguita-Gámez, Gonzalo J. López Martín, Javier Sánchez-González, and, B. Ibáñez
Introduction and objectives: Ischemic postconditioning (iPost, coronary intermittent re-occlusion maneuvers immediately after PCI-mediated reperfusion) has been proposed to limit infarct size (IS). However, a few experimental and clinical contradictory results have been reported. We hypothesized that iPost cardioprotection is affected by the duration of ischemia. Our objective was to assess IS in the presence/absence of iPost in a pig model of myocardial infarction of variable ischemia duration. Methods: Large white pigs (n = 38) underwent angioplasty balloon-induced coronary ischemia followed by reperfusion. Two set of experiments were carried out: intermediate (30 min) and prolonged (40 min) ischemia. In both, pigs were allocated on a 1:1 ratio to receive iPost (4 cycles of “1 min balloon inflation followed by 1 min deflation” upon reperfusion) or control. Animals underwent contrast-enhanced multiparametric cardiac magnetic resonance scan on day 7. Primary outcome measure was cardiac magnetic resonance-based IS (% of left ventricular mass). The interaction between treatment allocation and ischemia duration was assessed using a 2-way ANOVA test. Results: iPost was not associated with smaller IS in any of the ischemia duration protocols (intermediate ischemia: 0.3% [0.0 – 3.9] vs 0.9% [0.0 – 2.6] in iPost and control, respectively; P = .378; long ischemia: 31.1% [27.3 – 32.8] vs 27.3% [25.1 – 27.5]; P = .248). When both ischemia-duration protocols were combined, iPost was not associated with smaller IS (3.9% [0.0 – 30.9] vs 4.6% [0.2 – 25.1]; P = .672). T1 relaxation times were longer in animals undergoing iPost compared to controls (1306.2 ms [1190.7 – 1492.7] vs 1240.7 ms [1167.1 – 1304.5]; P = .024). Conclusions: In a pig model of reperfused myocardial infarction of variable ischemia duration, iPost failed to reduce IS. T1 relaxation times were longer in animals undergoing iPost indicative of the potential harm involved in this procedure.
引言和目的:缺血后处理(iPost,PCI介导的再灌注后立即进行冠状动脉间歇性再闭塞操作)已被提出用于限制梗死面积(IS)。然而,已经报道了一些实验和临床上相互矛盾的结果。我们假设iPost的心脏保护作用受缺血持续时间的影响。我们的目的是在不同缺血时间的猪心肌梗死模型中,在iPost存在/不存在的情况下评估IS。方法:大白猪(n=38)接受血管成形术球囊诱导的冠状动脉缺血再灌注。进行了两组实验:中间(30分钟)和延长(40分钟)缺血。在这两种情况下,猪以1:1的比例被分配接受iPost(再灌注后“1分钟球囊膨胀,然后1分钟放气”的4个周期)或对照。动物在第7天接受对比增强多参数心脏磁共振扫描。主要转归指标是基于心脏磁共振的IS(占左心室质量的%)。使用双向ANOVA检验评估治疗分配和缺血持续时间之间的相互作用。结果:在任何缺血持续时间方案中,iPost都与较小的IS无关(iPost和对照组中,中度缺血:分别为0.3%[0.0-3.9]和0.9%[0.0-2.6];P=.378;长期缺血:31.1%[27.3-32.8]和27.3%[25.1-27.5];P=.248),iPost与较小的IS无关(3.9%[0.0-30.9]vs 4.6%[0.2-25.1];P=.672)。与对照组相比,接受iPost的动物的T1弛豫时间更长(1306.2 ms[110.7–1492.7]vs 1240.7 ms[1167.1–1304.5];P=.024)。结论:在可变缺血时间的再灌注心肌梗死猪模型中,iPost未能降低IS。在接受iPost的动物中,T1弛豫时间更长,这表明该过程中涉及的潜在危害。
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引用次数: 0
Cost-effectiveness of SAPIEN 3 transcatheter aortic valve implantation in low surgical mortality risk patients in Spain 西班牙SAPIEN3经导管主动脉瓣植入术治疗低手术死亡率患者的成本效益
Q2 Medicine Pub Date : 2022-10-19 DOI: 10.24875/recice.m22000340
J. V. Vázquez Rodríguez, E. Pinar Bermúdez, J. Luis Zamorano, J. Moreu Burgos, J. Díaz-Fernández, Bruno García del Blanco, A. Sarmah, P. Candolfi, Judith Shore, and, Michelle Green
Introduction and objectives: Transcatheter aortic valve implantation (TAVI) was first introduced in 2007 as an alternative to open heart surgery to treat patients with severe symptomatic aortic stenosis (sSAS) with various indication expansions since that date. Recently, the PARTNER 3 study (Placement of aortic transcatheter valve) demonstrated clinical benefits with TAVI with the SAPIEN 3 valve vs surgical aortic valve replacement (SAVR) in selected low surgical mortality risk patients. We reviewed data from the PARTNER 3 and economic data from Spain to assess the cost-effectiveness ratio of TAVI vs SAVR in patients with sSAS and low surgical mortality risk. Methods: A 2-stage model was used to estimate direct healthcare costs and health-related quality of life data regarding TAVI with the SAPIEN 3 valve and SAVR. Early adverse events associated with TAVI from the PARTNER 3 were fed into a Markov model that captured longer-term outcomes after TAVI or SAVR. Results: TAVI with SAPIEN 3 improved quality-adjusted life years per patient (+ 1.00) with an increase in costs vs SAVR (€6971 per patient). This meant an incremental cost-effectiveness ratio/quality-adjusted life year of €6952 per patient. The results were robust with TAVI with the SAPIEN 3 valve remaining cost-effective across several sensitivity analyses. Conclusions: TAVI with the SAPIEN 3 valve is cost effective compared to SAVR in patients with sSAS and low surgical mortality risk. These findings can inform policymakers to facilitate policy development in Spain on intervention selection in this patient population. 3 valve was more clinically favorable compared to SAVR in patients with sSAS and low surgical mortality risk. The results of this robust, cost-effective- ness analysis indicate that, in Spain, TAVI could provide a cost-effective option over SAVR for this population with an estimated ICER/QALY value well below the national threshold. Data from the PARTNER 3 together with data from this cost-effectiveness analysis can support policy makers and healthcare budget holders to optimize the management of Spanish patients with sSAS.
简介和目的:经导管主动脉瓣植入术(TAVI)于2007年首次引入,作为心脏直视手术的替代方案,用于治疗自那时起各种适应症扩大的严重症状性主动脉瓣狭窄(sSAS)患者。最近,PARTNER 3研究(经导管主动脉瓣置入术)表明,在选择的低手术死亡率患者中,使用SAPIEN 3瓣膜的TAVI与手术主动脉瓣置换术(SAVR)相比具有临床益处。我们回顾了PARTNER 3的数据和西班牙的经济数据,以评估TAVI与SAVR在低手术死亡风险的sSAS患者中的成本-效果比。方法:采用两阶段模型估计与SAPIEN 3瓣膜和SAVR相关的TAVI的直接医疗保健费用和健康相关的生活质量数据。PARTNER 3中与TAVI相关的早期不良事件被输入马尔可夫模型,该模型捕获了TAVI或SAVR后的长期结果。结果:与SAVR相比,SAPIEN 3的TAVI提高了每位患者的质量调整生命年(+ 1.00),成本增加(每位患者6971欧元)。这意味着每位患者的增量成本效益比/质量调整生命年为6952欧元。TAVI的结果是稳健的,SAPIEN 3阀在几个敏感性分析中仍然具有成本效益。结论:在sSAS患者中,与SAVR相比,SAPIEN 3瓣膜的TAVI具有成本效益,手术死亡率低。这些发现可以为决策者提供信息,以促进西班牙在这一患者群体中选择干预措施的政策制定。在sSAS患者中,与SAVR相比,3瓣在临床上更有利,手术死亡率低。这一强有力的、具有成本效益的分析结果表明,在西班牙,TAVI可以为这一人群提供比SAVR更具成本效益的选择,其估计的ICER/QALY值远低于国家门槛。PARTNER 3的数据以及本成本效益分析的数据可以支持政策制定者和医疗保健预算持有人优化对西班牙sSAS患者的管理。
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引用次数: 1
Impella-Clip: a secure and effective strategy in cardiogenic shock due to acute severe mitral regurgitation 叶轮夹:急性严重二尖瓣反流所致心源性休克的一种安全有效的治疗策略
Q2 Medicine Pub Date : 2022-10-19 DOI: 10.24875/recice.m22000317
C. Ugueto-Rodrigo, A. Jurado-Román, Lucía Fernández-Gassó, Guillermo Galeote-García, and, Raúl Moreno
PRESENTATION This is the case of a 61-year-old man with cardiovascular risk factors who presents with a 3-day history of intermittent oppressive pain in the middle of his chest. The electrocardiogram confirmed the presence of an inferior-posterior wall ST-segment elevation. The emergency coronary angiography revealed the acute occlusion of a dominant left circumflex artery (videos 1 and 2 of the supplementary data) that was revascularized with 2 drug-eluting stents in the proximal left circumflex artery (bifurcation with the first obtuse marginal artery) using the TAP technique (T and small protrusion) (figure 1 and video 3 of the supplementary data). No other significant epicardial lesions were found. During the procedure the patient became desaturated, developed progressive hypotension, and eventually required invasive mechanical ventilation and intra-aortic
这是一例61岁的男性心血管危险因素,他有3天的胸部中部间歇性压迫性疼痛病史。心电图证实存在下后壁ST段抬高。急诊冠状动脉造影显示,主旋左动脉急性闭塞(补充数据的视频1和2),该动脉使用TAP技术(T和小突起)在旋左动脉近端(与第一钝缘动脉分叉)用2个药物洗脱支架进行血运重建(补充数据图1和视频3)。没有发现其他明显的心外膜病变。在手术过程中,患者变得不饱和,出现进行性低血压,最终需要有创机械通气和主动脉内通气
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引用次数: 0
Impella-Clip: a secure and effective strategy in cardiogenic shock due to acute severe mitral regurgitation. How would I approach it? Impella Clip:一种安全有效的治疗急性严重二尖瓣反流引起的心源性休克的策略。我该如何处理?
Q2 Medicine Pub Date : 2022-10-19 DOI: 10.24875/recice.m22000318
I. Pascual
As in the case presented here, these are often inferior or inferior-posterior wall myocardial infarctions due to the occlusions of very-well developed left circumflex arteries or very dominant right coronary arteries. These are high-surgical risk patients following their poor clinical and hemodynamic situation. Although, traditionally, the only possible procedure for these patients was mitral valve repair or replacement surgery, surgical results are associated with a high in-hospital mortality rate due to both these patients’ unstable clinical situation and procedural complications.1
如本文所述,这些通常是由于发育良好的左回旋支或占主导地位的右冠状动脉闭塞而引起的下壁或下壁后壁心肌梗死。这些患者的临床和血流动力学状况不佳,属于高手术风险患者。尽管传统上,这些患者唯一可能的手术是二尖瓣修复或置换手术,但由于这些患者的临床状况不稳定和手术并发症,手术结果与高住院死亡率相关。1
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引用次数: 0
REC: Interventional Cardiology: on the right track REC:介入心脏病学:在正确的轨道上
Q2 Medicine Pub Date : 2022-10-03 DOI: 10.24875/recice.m22000335
J. M. Torre-Hernández, F. Alfonso, Raúl Moreno, S. Ojeda, Armando Pérez de Prado, and, R. Romaguera
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引用次数: 1
Role of transseptal approach during TAVI in a patient with uncrossable severe bicuspid aortic stenosis 经中隔入路在TAVI中对一例无法跨越的严重二尖瓣主动脉狭窄患者的作用
Q2 Medicine Pub Date : 2022-09-26 DOI: 10.24875/recice.m22000310
Julia Martínez-Solé, S. Lozano-Edo, F. Ten-Morro, L. Andrés-Lalaguna, Jorge Sanz-Sánchez, and, J. L. Diez-Gil
As it was shown in the case presented here, patients with BAV disease undergoing TAVI represent a challenging scenario
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引用次数: 0
Role of transseptal approach during TAVI in a patient with uncrossable severe bicuspid aortic stenosis. How would I approach it? 经中隔入路在TAVI中对一例不可交叉的严重二叶主动脉狭窄患者的作用。我该如何处理?
Q2 Medicine Pub Date : 2022-09-26 DOI: 10.24875/recice.m22000311
J. A. Baz Alonso
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引用次数: 0
The forgotten stent 被遗忘的支架
Q2 Medicine Pub Date : 2022-09-23 DOI: 10.24875/recice.m22000339
Daniel Tébar, Alfonso Jurado Román, S. Jiménez Valero, Guillermo Galeote, and, Raúl Moreno
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引用次数: 0
Vascular access approach for structural heart procedures 结构性心脏手术的血管通路方法
Q2 Medicine Pub Date : 2022-09-23 DOI: 10.24875/recice.m22000331
X. Freixa, R. Romaguera, J. Botas, R. Trillo, Javier Martín-Moreiras, and, Alfonso Jurado-Román
Vascular access is an essential part of all interventional procedures whether coronary or structural. Over the last 15 to 20 years, in coronary interventions, traditional femoral access has been mostly replaced by the radial approach. Nonetheless, the femoral approach through both artery and vein is still the main approach for structural heart procedures. Over the last few years, femoral access has evolved from a puncture guided by anatomical references to more accurate ultrasound-guided approaches. The relatively recent introduction of interventions such as transcatheter aortic valve replacement has conditioned the use of large introducers and ultimately the need for specific hemostatic systems, above all, percutaneous closure devices. This manuscript reviews different anatomical concepts, puncture techniques, diagnostic assessments, and closure strategies of the main arterial and venous approaches for the diagnosis and treatment of different structural heart procedures. El acceso vascular es una parte esencial de
血管通路是所有介入手术的重要组成部分,无论是冠状动脉介入还是结构性介入。在过去的15到20年里,在冠状动脉介入治疗中,传统的股骨入路大多被放射入路取代。尽管如此,通过动脉和静脉的股骨入路仍然是结构性心脏手术的主要入路。在过去的几年里,股骨入路已经从解剖学参考引导的穿刺发展到更准确的超声引导入路。最近引入的干预措施,如经导管主动脉瓣置换术,限制了大型导入器的使用,并最终需要特定的止血系统,最重要的是,经皮封堵装置。本文综述了用于诊断和治疗不同结构心脏手术的主要动脉和静脉入路的不同解剖概念、穿刺技术、诊断评估和闭合策略。血管的一部分
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引用次数: 1
期刊
REC Interventional Cardiology English Ed
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