clinical practice guidelines that Abstract Chronic kidney disease is a growing syndrome of high prevalence, characterized by alterations in water, mineral and acid-base balance. It is strongly associated with other comorbidities, one of which being cardiovascular disease which not only is a causative factor but most importantly the result of the progression of renal disease. Sedentary life, dysregulation of blood pressure and lipid metabolism, inflammation, oxidative stress and endothelial dysfunction are considered to be the principal factors leading to cardiovascular deterioration in these patients. Aerobic exercise is a main therapeutic strategy targeting better cardiovascular outcomes in the general population with proven benefits on physical fitness status, visceral fat reduction and blood pressure control. In our review, we assessed the effects of aerobic exercise on cardiovascular function of renal disease patients and confirmed its beneficial effects on traditional risk factors of cardiovascular disease such as physical fitness status, body mass index and visceral fat reduction. However, no significant alterations in non-traditional aspects of cardiovascular disease such as inflammation, vascular function, and lipid metabolism were found because chronic kidney disease patients are rarely encouraged to exercise and there is a lack in adequate evidence from big trials to clarify the potency of aerobic exercise on these factors.
{"title":"The effect of exercise on cardiovascular function of patients with chronic kidney disease","authors":"K. Kanellopoulou","doi":"10.22540/jrpms-06-088","DOIUrl":"https://doi.org/10.22540/jrpms-06-088","url":null,"abstract":"clinical practice guidelines that Abstract Chronic kidney disease is a growing syndrome of high prevalence, characterized by alterations in water, mineral and acid-base balance. It is strongly associated with other comorbidities, one of which being cardiovascular disease which not only is a causative factor but most importantly the result of the progression of renal disease. Sedentary life, dysregulation of blood pressure and lipid metabolism, inflammation, oxidative stress and endothelial dysfunction are considered to be the principal factors leading to cardiovascular deterioration in these patients. Aerobic exercise is a main therapeutic strategy targeting better cardiovascular outcomes in the general population with proven benefits on physical fitness status, visceral fat reduction and blood pressure control. In our review, we assessed the effects of aerobic exercise on cardiovascular function of renal disease patients and confirmed its beneficial effects on traditional risk factors of cardiovascular disease such as physical fitness status, body mass index and visceral fat reduction. However, no significant alterations in non-traditional aspects of cardiovascular disease such as inflammation, vascular function, and lipid metabolism were found because chronic kidney disease patients are rarely encouraged to exercise and there is a lack in adequate evidence from big trials to clarify the potency of aerobic exercise on these factors.","PeriodicalId":348886,"journal":{"name":"Journal of Research and Practice on the Musculoskeletal System","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124435953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
the diagnostic Abstract Objectives : The present study was carried out to evaluate diagnostic accuracy of ultrasound (US) in delineating various rotator cuff and associated non rotator cuff pathologies (RCPs) of shoulder joint compared to Magnetic Resonance Imaging (MRI). Methods : Fifty consecutive symptomatic subjects in age-group 18-75 years (mean ± SD: 56.0 ± 13.6 years; 39-male, 11-female) were evaluated. US performer and MRI reporting radiologists were blinded to results of each-other. The sensitivity, specificity, and accuracy of US was measured for diagnosing various musculo-tendinous pathologies of shoulder against MRI gold standard. Results : MRI detected RCPs in all subjects while US was abnormal in 46(92%) cases. Supraspinatus was the most frequently affected tendon. Remarkably, 28% patient had polytendon abnormalities. US showed sensitivity of 84% and specificity of 87.5% for tendinosis; sensitivity of 78.1% and specificity of 94.4% for partial thickness tear (PTT) and 100% sensitivity and specificity for diagnosing full thickness tear. However, sensitivity of US for diagnosing PTT of infraspinatus tendon, subscapularis tendinosis and teres-minor atrophy was low. US had high specificity for diagnosing non-RCPs but sensitivity was low. Conclusions : A normal shoulder US may not rule out with certainty some rotator cuff and associated non-rotator cuff abnormalities. It is suggested to search for polytendon abnormalities which may be missed.
{"title":"Diagnostic accuracy of ultrasound in rotator cuff and associated non-rotator cuff pathologies of shoulder joint compared to magnetic resonance imaging","authors":"A. Gupta, S. R. Nayak, P. Bahinipati","doi":"10.22540/jrpms-06-072","DOIUrl":"https://doi.org/10.22540/jrpms-06-072","url":null,"abstract":"the diagnostic Abstract Objectives : The present study was carried out to evaluate diagnostic accuracy of ultrasound (US) in delineating various rotator cuff and associated non rotator cuff pathologies (RCPs) of shoulder joint compared to Magnetic Resonance Imaging (MRI). Methods : Fifty consecutive symptomatic subjects in age-group 18-75 years (mean ± SD: 56.0 ± 13.6 years; 39-male, 11-female) were evaluated. US performer and MRI reporting radiologists were blinded to results of each-other. The sensitivity, specificity, and accuracy of US was measured for diagnosing various musculo-tendinous pathologies of shoulder against MRI gold standard. Results : MRI detected RCPs in all subjects while US was abnormal in 46(92%) cases. Supraspinatus was the most frequently affected tendon. Remarkably, 28% patient had polytendon abnormalities. US showed sensitivity of 84% and specificity of 87.5% for tendinosis; sensitivity of 78.1% and specificity of 94.4% for partial thickness tear (PTT) and 100% sensitivity and specificity for diagnosing full thickness tear. However, sensitivity of US for diagnosing PTT of infraspinatus tendon, subscapularis tendinosis and teres-minor atrophy was low. US had high specificity for diagnosing non-RCPs but sensitivity was low. Conclusions : A normal shoulder US may not rule out with certainty some rotator cuff and associated non-rotator cuff abnormalities. It is suggested to search for polytendon abnormalities which may be missed.","PeriodicalId":348886,"journal":{"name":"Journal of Research and Practice on the Musculoskeletal System","volume":"158 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123427354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The role of long non-coding RNAs in bone diseases","authors":"Cristina Elena Atudorei, Eleana Fitsi, S. Rizou","doi":"10.22540/jrpms-06-042","DOIUrl":"https://doi.org/10.22540/jrpms-06-042","url":null,"abstract":"","PeriodicalId":348886,"journal":{"name":"Journal of Research and Practice on the Musculoskeletal System","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131394625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association of the B-complex vitamins with osteoporosis and osteoporotic fractures","authors":"Elpida D. Sachinidi","doi":"10.22540/jrpms-06-048","DOIUrl":"https://doi.org/10.22540/jrpms-06-048","url":null,"abstract":"","PeriodicalId":348886,"journal":{"name":"Journal of Research and Practice on the Musculoskeletal System","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114438374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Current treatment of infected arthroplasties","authors":"Elisavet Mantzila, E. Chronopoulos","doi":"10.22540/jrpms-06-031","DOIUrl":"https://doi.org/10.22540/jrpms-06-031","url":null,"abstract":"","PeriodicalId":348886,"journal":{"name":"Journal of Research and Practice on the Musculoskeletal System","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122477213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"RANK, RANK-L and OPG system as a prognostic and severity indicator for metastatic bone disease","authors":"A. Chaliasou, Christos Zafeiris","doi":"10.22540/jrpms-06-037","DOIUrl":"https://doi.org/10.22540/jrpms-06-037","url":null,"abstract":"","PeriodicalId":348886,"journal":{"name":"Journal of Research and Practice on the Musculoskeletal System","volume":"440 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116020576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Communication of patients and healthcare personnel during the diagnostic radiological process","authors":"Kalliopi Alamanioti, G. Lambrou","doi":"10.22540/jrpms-06-055","DOIUrl":"https://doi.org/10.22540/jrpms-06-055","url":null,"abstract":"","PeriodicalId":348886,"journal":{"name":"Journal of Research and Practice on the Musculoskeletal System","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128661731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Vatkar, S. Kale, S. Mehra, P. Bhor, A. Gunjotikar, Nikhil Isaacs
A rare autosomal recessive genetic disease, Xeroderma Pigmentosum (XP) starts in the childhood. Clinically, it develops as cutaneous photosensitivity and pigmentary changes in UV exposed areas of the body. DNA damage that is unrepaired and unresolved by the mutated XP genes leads to an increased risk of development of cancer. Continued exposure to UV radiation may lead to development of skin cancer. In 30% of XP patients, there is also development of neurological disorders with more chances for CNS neoplasms. Patients with XP have reduced interferon IFN-γ production, lower natural killer (NK) cell activation, and less circulating T cell numbers. These NK cells and T cells are important in preventing infection and neoplasm. The ratio of CD3+ to CD4+ circulating lymphocyte is reduced in XP. Studies have shown the role of an inhibitory serum factor to Phytohemagglutinin (PHA) stimulation in XP patients which might cause a serious hampering of the delayed hypersensitivity response. Activated macrophages are the main effector cells involved in the elimination of M. tuberculosis. This activation of macrophages is clearly led by lymphocyte products, mainly IFN-γ, and proinflammatory cytokines like TNF-α. Delayed hypersensitivity is a major mechanism of defense against many intracellular pathogenic organisms. These include mycobacteria, fungi, and certain parasites. Immunodeficiency in XP patients is not only associated with increased chances of neoplasms, but also increased susceptibility to infections like tuberculosis.
{"title":"Primary Multi Drug Resistant Tuberculosis (MDR TB) Osteomyelitis in Sternum associated with Xeroderma Pigmentosa: A Case Report","authors":"A. Vatkar, S. Kale, S. Mehra, P. Bhor, A. Gunjotikar, Nikhil Isaacs","doi":"10.22540/jrpms-06-014","DOIUrl":"https://doi.org/10.22540/jrpms-06-014","url":null,"abstract":"A rare autosomal recessive genetic disease, Xeroderma Pigmentosum (XP) starts in the childhood. Clinically, it develops as cutaneous photosensitivity and pigmentary changes in UV exposed areas of the body. DNA damage that is unrepaired and unresolved by the mutated XP genes leads to an increased risk of development of cancer. Continued exposure to UV radiation may lead to development of skin cancer. In 30% of XP patients, there is also development of neurological disorders with more chances for CNS neoplasms. Patients with XP have reduced interferon IFN-γ production, lower natural killer (NK) cell activation, and less circulating T cell numbers. These NK cells and T cells are important in preventing infection and neoplasm. The ratio of CD3+ to CD4+ circulating lymphocyte is reduced in XP. Studies have shown the role of an inhibitory serum factor to Phytohemagglutinin (PHA) stimulation in XP patients which might cause a serious hampering of the delayed hypersensitivity response. Activated macrophages are the main effector cells involved in the elimination of M. tuberculosis. This activation of macrophages is clearly led by lymphocyte products, mainly IFN-γ, and proinflammatory cytokines like TNF-α. Delayed hypersensitivity is a major mechanism of defense against many intracellular pathogenic organisms. These include mycobacteria, fungi, and certain parasites. Immunodeficiency in XP patients is not only associated with increased chances of neoplasms, but also increased susceptibility to infections like tuberculosis.","PeriodicalId":348886,"journal":{"name":"Journal of Research and Practice on the Musculoskeletal System","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126667916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Efthimia Tsoukala, Georgia Chochtoula, Iosifina Theodorou, G. Lambrou
{"title":"Dentinogenesis imperfecta: An update","authors":"Efthimia Tsoukala, Georgia Chochtoula, Iosifina Theodorou, G. Lambrou","doi":"10.22540/jrpms-06-009","DOIUrl":"https://doi.org/10.22540/jrpms-06-009","url":null,"abstract":"","PeriodicalId":348886,"journal":{"name":"Journal of Research and Practice on the Musculoskeletal System","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117161624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bone defects in the oral cavity differ greatly, ranging from limited alveolar bone loss to large-scale bone atrophy. A “jaw (bone) defect” is defined as the lack of bone volume where it should normally exist. A variety of reasons can cause jaw deformities such as extractions/ tooth loss, periodontitis, periapical infections, injuries due to facial trauma, tumors or cyst resections, congenitally missing teeth or developmental conditions (cleft palate defects), osteomyelitis, osteoradionecrosis and druginduced osteonecrosis. The most common cause is the post-extraction alveolar ridge collapse, which is inevitable and leads to bone loss in both horizontal and vertical dimensions. The above is clinically relevant when implant replacements are to be inserted as their position in the jaws should be driven by the restorative plan. Regardless of the cause of jaw deficiencies, reconstruction of the maxilla and the mandible is imperative for the return to form and function. Reconstructive jaw surgery may involve a multitude of different bone grafting materials such as autografts, allografts, xenografts and alloplasts. Autologous bone grafts are considered to be the gold standard for bone regeneration because of histocompatibility and their osteogenic, osteoconductive and osteoinductive properties. However, autografts show some disadvantages due to their limited supply, donor-site morbidity and potential infections. On the other hand, allografts and xenografts do not have the problem of limited supply and do not require a donor site but they have poor osteoinductive properties due to the absence of cell populations. To overcome these difficulties, new advanced techniques have been employed and one of the most promising is the use of stem cells. By the term “stem cells” we define the cells with the ability to grow into anyone of the human body’s more than 200 cell types, responsible for the foundation of each and every organ and tissue. They have two defining characteristics; the ability of unlimited self-renewal and the ability to differentiate into specialized adult cell type with specific functions, when stimulated by both external and internal signals. Abstract
{"title":"The role of stem cells in oral bone regeneration","authors":"Garyfallia Kremmyda","doi":"10.22540/jrpms-06-001","DOIUrl":"https://doi.org/10.22540/jrpms-06-001","url":null,"abstract":"Bone defects in the oral cavity differ greatly, ranging from limited alveolar bone loss to large-scale bone atrophy. A “jaw (bone) defect” is defined as the lack of bone volume where it should normally exist. A variety of reasons can cause jaw deformities such as extractions/ tooth loss, periodontitis, periapical infections, injuries due to facial trauma, tumors or cyst resections, congenitally missing teeth or developmental conditions (cleft palate defects), osteomyelitis, osteoradionecrosis and druginduced osteonecrosis. The most common cause is the post-extraction alveolar ridge collapse, which is inevitable and leads to bone loss in both horizontal and vertical dimensions. The above is clinically relevant when implant replacements are to be inserted as their position in the jaws should be driven by the restorative plan. Regardless of the cause of jaw deficiencies, reconstruction of the maxilla and the mandible is imperative for the return to form and function. Reconstructive jaw surgery may involve a multitude of different bone grafting materials such as autografts, allografts, xenografts and alloplasts. Autologous bone grafts are considered to be the gold standard for bone regeneration because of histocompatibility and their osteogenic, osteoconductive and osteoinductive properties. However, autografts show some disadvantages due to their limited supply, donor-site morbidity and potential infections. On the other hand, allografts and xenografts do not have the problem of limited supply and do not require a donor site but they have poor osteoinductive properties due to the absence of cell populations. To overcome these difficulties, new advanced techniques have been employed and one of the most promising is the use of stem cells. By the term “stem cells” we define the cells with the ability to grow into anyone of the human body’s more than 200 cell types, responsible for the foundation of each and every organ and tissue. They have two defining characteristics; the ability of unlimited self-renewal and the ability to differentiate into specialized adult cell type with specific functions, when stimulated by both external and internal signals. Abstract","PeriodicalId":348886,"journal":{"name":"Journal of Research and Practice on the Musculoskeletal System","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126252389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：