A. C. Hadjimichael, A. Foukas, A. Antonopoulos, O. Savvidou, P. Papagelopoulos
Argyris Costa Hadjimichael, Athanasios Fotios Foukas, Athanasios Antonopoulos, Olga Savvidou, Panayiotis Papagelopoulos 3 Orthopaedic Department, KAT Hospital, Athens, Greece; Postgraduate MSc program “Metabolic Bone Diseases”, National and Kapodistrian University of Athens, Medical School; 1 Department of Orthopedic Surgery, National and Kapodistrian University of Athens, Medical School, ATTIKON University Hospital, Athens, Greece
Argyris Costa hadjimmichael, Athanasios Fotios Foukas, Athanasios Antonopoulos, Olga Savvidou, Panayiotis Papagelopoulos 3希腊雅典KAT医院骨科;雅典国立和Kapodistrian大学医学院“代谢性骨病”研究生硕士课程;1雅典国立和卡波迪斯特里安大学医学院，雅典ATTIKON大学医院骨科，希腊雅典
{"title":"Risk factors for periprosthetic joint infection following total hip and knee arthroplasty","authors":"A. C. Hadjimichael, A. Foukas, A. Antonopoulos, O. Savvidou, P. Papagelopoulos","doi":"10.22540/jrpms-03-087","DOIUrl":"https://doi.org/10.22540/jrpms-03-087","url":null,"abstract":"Argyris Costa Hadjimichael, Athanasios Fotios Foukas, Athanasios Antonopoulos, Olga Savvidou, Panayiotis Papagelopoulos 3 Orthopaedic Department, KAT Hospital, Athens, Greece; Postgraduate MSc program “Metabolic Bone Diseases”, National and Kapodistrian University of Athens, Medical School; 1 Department of Orthopedic Surgery, National and Kapodistrian University of Athens, Medical School, ATTIKON University Hospital, Athens, Greece","PeriodicalId":348886,"journal":{"name":"Journal of Research and Practice on the Musculoskeletal System","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114929284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giant cell tumors (GCTs) are primary locally aggressive bone tumors that represent 5% of all bone neoplasms. They have a female predominance and they are most common in patients aged 20 to 40 years. In Oriental and Asian populations incidence may reach 20% of bone neoplasms while it is more uncommon in Caucasians. Pain is the most common presenting symptom while pathologic fractures may occur in 11-37% of the cases. Distal femur, proximal tibia and distal radius are the most common sites involved with 50% of the cases diagnosed around the knee area (Figure 1). These neoplasms are characterized by osteoclast-like giant multinucleate cells (Figure 2). Thus, radiographically they appear as pure osteolytic eccentric lesions of the epiphysis extending to the articular surface or the diaphysis (Figure 3). GCTs are usually highly destructive solitary lesions commonly extending to the surrounding soft tissue, however 1% to 2% may simultaneously or sequentially be multicentric. Although classified as primary benign bone tumors, in 1-3% of GCTs spontaneous transformation to a high-grade Abstract
{"title":"Malignant giant cell tumor of bone","authors":"E. Neonakis, G. Antoniou, I. Triantafyllopoulos","doi":"10.22540/jrpms-03-083","DOIUrl":"https://doi.org/10.22540/jrpms-03-083","url":null,"abstract":"Giant cell tumors (GCTs) are primary locally aggressive bone tumors that represent 5% of all bone neoplasms. They have a female predominance and they are most common in patients aged 20 to 40 years. In Oriental and Asian populations incidence may reach 20% of bone neoplasms while it is more uncommon in Caucasians. Pain is the most common presenting symptom while pathologic fractures may occur in 11-37% of the cases. Distal femur, proximal tibia and distal radius are the most common sites involved with 50% of the cases diagnosed around the knee area (Figure 1). These neoplasms are characterized by osteoclast-like giant multinucleate cells (Figure 2). Thus, radiographically they appear as pure osteolytic eccentric lesions of the epiphysis extending to the articular surface or the diaphysis (Figure 3). GCTs are usually highly destructive solitary lesions commonly extending to the surrounding soft tissue, however 1% to 2% may simultaneously or sequentially be multicentric. Although classified as primary benign bone tumors, in 1-3% of GCTs spontaneous transformation to a high-grade Abstract","PeriodicalId":348886,"journal":{"name":"Journal of Research and Practice on the Musculoskeletal System","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134178094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Postgraduate Program “Metabolic Bones Diseases”, National and Kapodistrian University of Athens, Medical School, Athens, Greece; “G.Gennimatas” General Hospital, Athens, Greece; Laboratory for Research of the Musculoskeletal System “Th. Garofalidis”, Medical School, National and Kapodistrian University of Athens, General Hospital of Athens KAT, Greece; First Department of Pediatrics, National and Kapodistrian University of Athens, Choremeio Research Laboratory, Athens, Greece
{"title":"Imaging methods for the control and treatment of sarcopenia","authors":"Eleni Gioutlaki, Thomas Karyakatzis, G. Lambrou","doi":"10.22540/jrpms-03-102","DOIUrl":"https://doi.org/10.22540/jrpms-03-102","url":null,"abstract":"Postgraduate Program “Metabolic Bones Diseases”, National and Kapodistrian University of Athens, Medical School, Athens, Greece; “G.Gennimatas” General Hospital, Athens, Greece; Laboratory for Research of the Musculoskeletal System “Th. Garofalidis”, Medical School, National and Kapodistrian University of Athens, General Hospital of Athens KAT, Greece; First Department of Pediatrics, National and Kapodistrian University of Athens, Choremeio Research Laboratory, Athens, Greece","PeriodicalId":348886,"journal":{"name":"Journal of Research and Practice on the Musculoskeletal System","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126581938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ioanna Skoufou, Maria Yavropoulou, Christos Zafeiris Postgraduate Program “Metabolic Bone Diseases”, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece; Division of Endocrinology and Metabolism, 1st Propaedeutic Department of Internal Medicine LAIKO General Hospital of Athens, National and Kapodistrian University of Athens, Greece; Laboratory for Research of Musculoskeletal System “Theodoros Garofalidis”, University of Athens, KAT Hospital, Athens, Greece
Ioanna Skoufou, Maria Yavropoulou, Christos Zafeiris研究生项目“代谢性骨病”，雅典国立和Kapodistrian大学医学院，雅典，希腊;希腊雅典国立和卡波distrian大学雅典LAIKO总医院内科第一妇产科内分泌与代谢科;雅典大学肌肉骨骼系统“Theodoros Garofalidis”研究实验室，希腊雅典KAT医院
{"title":"Could treating periodontitis prevent osteoporosis? An update of the last decade","authors":"Ioanna Skoufou, M. Yavropoulou, Christos Zafeiris","doi":"10.22540/jrpms-03-096","DOIUrl":"https://doi.org/10.22540/jrpms-03-096","url":null,"abstract":"Ioanna Skoufou, Maria Yavropoulou, Christos Zafeiris Postgraduate Program “Metabolic Bone Diseases”, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece; Division of Endocrinology and Metabolism, 1st Propaedeutic Department of Internal Medicine LAIKO General Hospital of Athens, National and Kapodistrian University of Athens, Greece; Laboratory for Research of Musculoskeletal System “Theodoros Garofalidis”, University of Athens, KAT Hospital, Athens, Greece","PeriodicalId":348886,"journal":{"name":"Journal of Research and Practice on the Musculoskeletal System","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131091057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Papachrysanthou, M. Aktsiali, I. Griveas, Christos Andriopoulos, Panagiotis Sitaras, G. Lambrou
Theodora Papachrysanthou, Maria Aktsiali, Ioannis Griveas, Christos Andriopoulos, Panagiotis Sitaras, George I. Lambrou Private Dialysis Unit “Nefroiatriki”, Athens, Greece; Graduate Program “Metabolic Bones Diseases”, National and Kapodistrian University of Athens, Medical School, Athens, Greece; 417 Veterans Army Administration Hospital of Athens, Athens, Greece; National and Kapodistrian University of Athens, Medical School, Laboratory for the Research of Musculoskeletal Disorders, Athens, Greece; First Department of Pediatrics, University of Athens, Choremeio Research Laboratory, National and Kapodistrian University of Athens, Athens, Greece
Theodora Papachrysanthou、Maria Aktsiali、Ioannis Griveas、Christos Andriopoulos、Panagiotis Sitaras、George I. Lambrou私人透析单位Nefroiatriki，希腊雅典;研究生项目“代谢性骨骼疾病”，雅典国立和Kapodistrian大学医学院，雅典，希腊;417雅典退伍军人管理局医院，希腊雅典;雅典国立和Kapodistrian大学医学院肌肉骨骼疾病研究实验室，雅典，希腊;雅典大学第一儿科系，舞蹈研究实验室，雅典国立和卡波迪斯特里安大学，希腊雅典
{"title":"The relation of parathyroid hormone and hematologic parameters under erythropoetin administration in hemodialysis patients","authors":"T. Papachrysanthou, M. Aktsiali, I. Griveas, Christos Andriopoulos, Panagiotis Sitaras, G. Lambrou","doi":"10.22540/jrpms-03-106","DOIUrl":"https://doi.org/10.22540/jrpms-03-106","url":null,"abstract":"Theodora Papachrysanthou, Maria Aktsiali, Ioannis Griveas, Christos Andriopoulos, Panagiotis Sitaras, George I. Lambrou Private Dialysis Unit “Nefroiatriki”, Athens, Greece; Graduate Program “Metabolic Bones Diseases”, National and Kapodistrian University of Athens, Medical School, Athens, Greece; 417 Veterans Army Administration Hospital of Athens, Athens, Greece; National and Kapodistrian University of Athens, Medical School, Laboratory for the Research of Musculoskeletal Disorders, Athens, Greece; First Department of Pediatrics, University of Athens, Choremeio Research Laboratory, National and Kapodistrian University of Athens, Athens, Greece","PeriodicalId":348886,"journal":{"name":"Journal of Research and Practice on the Musculoskeletal System","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133001728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
It is well accepted for more than a century, that thyroid hormones are crucial for linear growth and skeletal maintenance. However, the empiric use of sponge and seaweed in the treatment of congenital hypothyroidism dates back to 1600 BC. In the middle of 18 century the first cases of hyperthyroidism have been reported and in 1840 Carl Adolf von Basedow contributed with a more complete description of the syndrome. However, it was Paul Möbius in1886 who linked the symptomatology to a hyperactive thyroid. In 1891, Friedrich Von Recklinghausen was the first to establish a connection between osteoporotic fractures and thyrotoxicosis. During the last 25 years, this topic has attracted substantial attention, guiding to important progress in comprehending the impact of thyroid disease on the growing and adult skeleton. This review aims to present the current knowledge of the consequences of both endogenous and exogenous subclinical hyperthyroidism (SH) on bone mineral density (BMD) and risk of fracture separately in men, pre-menopausal and post-menopausal women. At last, treatment management in accordance to recent international guidelines is also reported.
一个多世纪以来，人们普遍认为甲状腺激素对线性生长和骨骼维持至关重要。然而，使用海绵和海藻治疗先天性甲状腺功能减退的经验可以追溯到公元前1600年。18世纪中叶，甲亢的第一例病例被报道，1840年，卡尔·阿道夫·冯·巴塞多对该综合征做出了更完整的描述。然而，是保罗Möbius在1886年将症状学与甲状腺亢进联系起来。1891年，弗里德里希·冯·雷克林豪森(Friedrich Von Recklinghausen)首先建立了骨质疏松性骨折和甲状腺毒症之间的联系。在过去的25年中，这一主题引起了广泛的关注，在理解甲状腺疾病对生长和成人骨骼的影响方面取得了重要进展。本综述旨在介绍内源性和外源性亚临床甲状腺功能亢进(SH)对男性、绝经前和绝经后女性骨密度(BMD)和骨折风险的影响。最后，还报道了按照国际最新指南进行的治疗管理。
{"title":"Impact of subclinical hyperthyroidism on bone","authors":"S. Koutroumpi, T. Stratigou, V. Vlassopoulou","doi":"10.22540/JRPMS-03-060","DOIUrl":"https://doi.org/10.22540/JRPMS-03-060","url":null,"abstract":"It is well accepted for more than a century, that thyroid hormones are crucial for linear growth and skeletal maintenance. However, the empiric use of sponge and seaweed in the treatment of congenital hypothyroidism dates back to 1600 BC. In the middle of 18 century the first cases of hyperthyroidism have been reported and in 1840 Carl Adolf von Basedow contributed with a more complete description of the syndrome. However, it was Paul Möbius in1886 who linked the symptomatology to a hyperactive thyroid. In 1891, Friedrich Von Recklinghausen was the first to establish a connection between osteoporotic fractures and thyrotoxicosis. During the last 25 years, this topic has attracted substantial attention, guiding to important progress in comprehending the impact of thyroid disease on the growing and adult skeleton. This review aims to present the current knowledge of the consequences of both endogenous and exogenous subclinical hyperthyroidism (SH) on bone mineral density (BMD) and risk of fracture separately in men, pre-menopausal and post-menopausal women. At last, treatment management in accordance to recent international guidelines is also reported.","PeriodicalId":348886,"journal":{"name":"Journal of Research and Practice on the Musculoskeletal System","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131210768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Osteoporosis is a common, under-diagnosed and poorly treated complication of liver cirrhosis. The prevalence of osteoporosis in patients awaiting liver transplantation ranges from 12 to 55% and the prevalence of fractures is up to 22%, depending on the etiology of cirrhosis, the degree of liver insufficiency and the presence of additional predisposing factors, such as chronic cholestasis or use of corticoids. Overall, the fracture risk is estimated as double in cirrhotic patients compared to healthy individuals. In patients that undergo orthotopic liver transplantation (OLT), the pre-existing osteoporosis aggravates, mainly due to the immunosuppressive treatment with glucocorticoids and calcineurin inhibitors. The prevalence of bone disease after liver transplantations reaches 25% , and 15-30% of liver transplant recipients develop fractures shortly after the OLT, mainly vertebral ones. Improved survival rates of transplanted patients and the increased number of transplantations performed nowadays, have turned osteoporosis and its complications into an important cause of morbidity and mortality among this population.
{"title":"Multiple vertebral fractures in a liver transplant recipient with HCV cirrhosis: A case report","authors":"Elpida E. Ntofi, S. Tournis","doi":"10.22540/JRPMS-03-052","DOIUrl":"https://doi.org/10.22540/JRPMS-03-052","url":null,"abstract":"Osteoporosis is a common, under-diagnosed and poorly treated complication of liver cirrhosis. The prevalence of osteoporosis in patients awaiting liver transplantation ranges from 12 to 55% and the prevalence of fractures is up to 22%, depending on the etiology of cirrhosis, the degree of liver insufficiency and the presence of additional predisposing factors, such as chronic cholestasis or use of corticoids. Overall, the fracture risk is estimated as double in cirrhotic patients compared to healthy individuals. In patients that undergo orthotopic liver transplantation (OLT), the pre-existing osteoporosis aggravates, mainly due to the immunosuppressive treatment with glucocorticoids and calcineurin inhibitors. The prevalence of bone disease after liver transplantations reaches 25% , and 15-30% of liver transplant recipients develop fractures shortly after the OLT, mainly vertebral ones. Improved survival rates of transplanted patients and the increased number of transplantations performed nowadays, have turned osteoporosis and its complications into an important cause of morbidity and mortality among this population.","PeriodicalId":348886,"journal":{"name":"Journal of Research and Practice on the Musculoskeletal System","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126360495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
George E. Diakos and George I. Lambrou Laboratory for Research of the Musculoskeletal System “Th. Garofalidis”, Medical School, National and Kapodistrian University of Athens, General Hospital of Athens KAT, Greece; Postgraduate Program “Metabolic Bones Diseases”, National and Kapodistrian University of Athens, Medical School, Goudi, Athens, Greece; First Department of Pediatrics, National and Kapodistrian University of Athens, Choremeio Research Laboratory, Goudi, Athens, Greece
George E. Diakos和George I. Lambrou肌肉骨骼系统研究实验室。Garofalidis "，雅典国立和卡波迪斯特大学医学院，希腊雅典总医院;研究生课程“代谢性骨骼疾病”，雅典国立和卡波迪大学，医学院，古迪，雅典，希腊;雅典国立和卡波迪斯特兰大学第一儿科，希腊雅典古迪的Choremeio研究实验室
{"title":"The role of miRNAs in ankylosing spondylitis: a narrative review","authors":"G. Diakos, G. Lambrou","doi":"10.22540/JRPMS-03-045","DOIUrl":"https://doi.org/10.22540/JRPMS-03-045","url":null,"abstract":"George E. Diakos and George I. Lambrou Laboratory for Research of the Musculoskeletal System “Th. Garofalidis”, Medical School, National and Kapodistrian University of Athens, General Hospital of Athens KAT, Greece; Postgraduate Program “Metabolic Bones Diseases”, National and Kapodistrian University of Athens, Medical School, Goudi, Athens, Greece; First Department of Pediatrics, National and Kapodistrian University of Athens, Choremeio Research Laboratory, Goudi, Athens, Greece","PeriodicalId":348886,"journal":{"name":"Journal of Research and Practice on the Musculoskeletal System","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129512516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
the therapeutic approach chosen shortly after the onset of the disease, which may not include Methotrexate Abstract Rheumatoid Arthritis (RA) is a chronic, systemic, inflammatory disease that is characterised by inflammation of the synovial membrane and progressive destruction of articular cartilage and bone. Furthermore, RA is often associated with extra-articular manifestations. A multidisciplinary approach is required for patients with RA in the peri-operative period. This review discusses the pre-operative, peri-operative and post-operative management of patients with RA and attempts to provide plausible answers to challenging questions that arise often when patients with RA undergo surgery. The key issues a physician has to address include controlling disease activity, assisting the wound-healing process by eliminating any delaying factors related to RA and preventing post-operative complications that may occur. The peri-operative care of patients with RA must be (strictly) personalised, given that it has to take into account a wide set of factors such as the type of surgery and the anaesthesia needed, the disease activity, the current medication the patient receives and the risk factors of co-morbidity such as age, smoking and decreased cardiac, renal, pulmonary or peripheral vascular function.
{"title":"Perioperative medication management of patiens with Rheumatoid Arthritis","authors":"K. Zoupidou","doi":"10.22540/JRPMS-03-071","DOIUrl":"https://doi.org/10.22540/JRPMS-03-071","url":null,"abstract":"the therapeutic approach chosen shortly after the onset of the disease, which may not include Methotrexate Abstract Rheumatoid Arthritis (RA) is a chronic, systemic, inflammatory disease that is characterised by inflammation of the synovial membrane and progressive destruction of articular cartilage and bone. Furthermore, RA is often associated with extra-articular manifestations. A multidisciplinary approach is required for patients with RA in the peri-operative period. This review discusses the pre-operative, peri-operative and post-operative management of patients with RA and attempts to provide plausible answers to challenging questions that arise often when patients with RA undergo surgery. The key issues a physician has to address include controlling disease activity, assisting the wound-healing process by eliminating any delaying factors related to RA and preventing post-operative complications that may occur. The peri-operative care of patients with RA must be (strictly) personalised, given that it has to take into account a wide set of factors such as the type of surgery and the anaesthesia needed, the disease activity, the current medication the patient receives and the risk factors of co-morbidity such as age, smoking and decreased cardiac, renal, pulmonary or peripheral vascular function.","PeriodicalId":348886,"journal":{"name":"Journal of Research and Practice on the Musculoskeletal System","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131092654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Idiopathic primary hypoparathyroidism is an infrequent disease among adults, especially if not associated with genetic disease such as Di George syndrome. Most commonly hypoparathyroidism is a result of surgical removal of the parathyroid glands during operation in the cervical area. Sarcoidosis is a multiorgan granulomatous disease, more frequently encountered than primary hypothyroidism. Hypocalcaemia is the most common finding in hypoparathyroidism. The opposite characterizes, hypercalcaemia is finding, in some cases of sarcoidosis due to 1.25(OH) 2 D 3 from granulomas. Concomitant idiopathic hypoparathyroidism and sarcoidosis has rarely been described. Here, we describe a rare case of an elderly woman with idiopathic primary hypoparathyroidism who developed hypercalcaemia attributed to underlying sarcoidosis.
{"title":"Hypercalcaemia in an idiopathic hypoparathyroidism patient, due to sarcoidosis","authors":"Irena Karabella, Maria Meliou","doi":"10.22540/JRPMS-03-067","DOIUrl":"https://doi.org/10.22540/JRPMS-03-067","url":null,"abstract":"Idiopathic primary hypoparathyroidism is an infrequent disease among adults, especially if not associated with genetic disease such as Di George syndrome. Most commonly hypoparathyroidism is a result of surgical removal of the parathyroid glands during operation in the cervical area. Sarcoidosis is a multiorgan granulomatous disease, more frequently encountered than primary hypothyroidism. Hypocalcaemia is the most common finding in hypoparathyroidism. The opposite characterizes, hypercalcaemia is finding, in some cases of sarcoidosis due to 1.25(OH) 2 D 3 from granulomas. Concomitant idiopathic hypoparathyroidism and sarcoidosis has rarely been described. Here, we describe a rare case of an elderly woman with idiopathic primary hypoparathyroidism who developed hypercalcaemia attributed to underlying sarcoidosis.","PeriodicalId":348886,"journal":{"name":"Journal of Research and Practice on the Musculoskeletal System","volume":"139 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131247126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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