Meijin Lu, Silin Rao, Hong Yue, Junjie Han and Jingtao Wang*,
Crystals are integral to a variety of industrial applications, such as the development of pharmaceuticals and advancements in material science. To anticipate crystal behavior and pinpoint effective crystallization techniques, a thorough investigation of crystal structures, properties, and the associated processes is essential. However, conventional methods like experimental procedures and quantum mechanics calculations, while crucial, can be expensive and time-consuming. In response, machine learning has risen as an effective alternative, complementing the traditional approaches based on quantum mechanics and classical force fields. In the recent years, the deployment of machine learning in the realm of crystallization has yielded notable progress. This review offers a concise overview of the application of machine learning techniques in crystallization, focusing on the past five years. Our analysis of the literature indicates that machine learning has accelerated the prediction of crystal structures by streamlining the generation and evaluation of structures. Additionally, it has facilitated the prediction of key crystal properties such as solubility, melting point, and habit. The review further explores the role of machine learning in refining the control and optimization of crystallization processes, highlighting the restrictions of conventional algorithms and sensing technologies. The advantages of end-to-end processing for enhancing the accuracy of predictions and the combination of data-driven with mechanism-based models for robustness are also considered. In summary, this review provides insights into the current state of machine learning in the field of intelligent crystallization and suggests pathways for future research and development.
{"title":"Recent Advances in the Application of Machine Learning to Crystal Behavior and Crystallization Process Control","authors":"Meijin Lu, Silin Rao, Hong Yue, Junjie Han and Jingtao Wang*, ","doi":"10.1021/acs.cgd.3c01251","DOIUrl":"10.1021/acs.cgd.3c01251","url":null,"abstract":"<p >Crystals are integral to a variety of industrial applications, such as the development of pharmaceuticals and advancements in material science. To anticipate crystal behavior and pinpoint effective crystallization techniques, a thorough investigation of crystal structures, properties, and the associated processes is essential. However, conventional methods like experimental procedures and quantum mechanics calculations, while crucial, can be expensive and time-consuming. In response, machine learning has risen as an effective alternative, complementing the traditional approaches based on quantum mechanics and classical force fields. In the recent years, the deployment of machine learning in the realm of crystallization has yielded notable progress. This review offers a concise overview of the application of machine learning techniques in crystallization, focusing on the past five years. Our analysis of the literature indicates that machine learning has accelerated the prediction of crystal structures by streamlining the generation and evaluation of structures. Additionally, it has facilitated the prediction of key crystal properties such as solubility, melting point, and habit. The review further explores the role of machine learning in refining the control and optimization of crystallization processes, highlighting the restrictions of conventional algorithms and sensing technologies. The advantages of end-to-end processing for enhancing the accuracy of predictions and the combination of data-driven with mechanism-based models for robustness are also considered. In summary, this review provides insights into the current state of machine learning in the field of intelligent crystallization and suggests pathways for future research and development.</p>","PeriodicalId":34,"journal":{"name":"Crystal Growth & Design","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141381522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nea Baus Topić, Sibananda G. Dash, Edi Topić, Mihails Arhangelskis* and Dominik Cinčić*,
In this study, we examine the experimental and theoretical capabilities of two perhalogenated anilines, 2,3,5,6-tetrafluoro-4-bromoaniline (btfa) and 2,3,5,6-tetrafluoro-4-iodoaniline (itfa) as hydrogen and halogen bond donors. A series of 11 cocrystals derived from the two anilines and selected ditopic nitrogen-containing acceptors (4,4′-bipyridine, 1,2-bis(4-pyridyl)ethane, and 1,4-diazabicyclo[2.2.2]octane) in 1:1 and 2:1 stoichiometries were prepared by liquid-assisted grinding and crystallization from solution. Crystallographic analysis revealed bifunctional donor properties in both anilines. The dominant supramolecular interaction in four cocrystals of btfa is the N–H···Nacceptor hydrogen bond between btfa and acceptor molecules, while in the one remaining cocrystal, donor and acceptor molecules are connected via the N–H···Nacceptor hydrogen bond and the Br···Nacceptor halogen bond. In two cocrystals of itfa, the dominant supramolecular interaction is the I···Nacceptor halogen bond between itfa and acceptor molecules, while in the remaining four cocrystals, donor and acceptor molecules are additionally connected by the N–H···Nacceptor hydrogen bond. Periodic density-functional theory (DFT) calculations have been conducted to assess the formation energies of these cocrystals and the strengths of the established halogen and hydrogen bonds. Molecular DFT calculations on btfa and itfa indicate that the differences in electrostatic potential between the competing sites on the molecules are 261.6 and 157.0 kJ mol–1 e–1, respectively. The findings suggest that itfa, with a smaller electrostatic potential difference between donor sites, is more predisposed to act as a bifunctional donor.
The experimental and theoretical capability of two perhalogenated anilines, 2,3,5,6-tetrafluoro-4-bromoaniline and 2,3,5,6-tetrafluoro-4-iodoaniline, as hydrogen and halogen bond donors have been explored by cocrystallization with 4,4′-bipyridine, 1,2-bis(4-pyridyl)ethane, and 1,4-diazabicyclo[2.2.2]octane.
{"title":"Perhalogenated Anilines as Bifunctional Donors of Hydrogen and Halogen Bonds in Cocrystals with Ditopic Nitrogen-Containing Acceptors","authors":"Nea Baus Topić, Sibananda G. Dash, Edi Topić, Mihails Arhangelskis* and Dominik Cinčić*, ","doi":"10.1021/acs.cgd.4c00315","DOIUrl":"10.1021/acs.cgd.4c00315","url":null,"abstract":"<p >In this study, we examine the experimental and theoretical capabilities of two perhalogenated anilines, 2,3,5,6-tetrafluoro-4-bromoaniline (<b>btfa</b>) and 2,3,5,6-tetrafluoro-4-iodoaniline (<b>itfa</b>) as hydrogen and halogen bond donors. A series of 11 cocrystals derived from the two anilines and selected ditopic nitrogen-containing acceptors (4,4′-bipyridine, 1,2-bis(4-pyridyl)ethane, and 1,4-diazabicyclo[2.2.2]octane) in 1:1 and 2:1 stoichiometries were prepared by liquid-assisted grinding and crystallization from solution. Crystallographic analysis revealed bifunctional donor properties in both anilines. The dominant supramolecular interaction in four cocrystals of <b>btfa</b> is the N–H···N<sub>acceptor</sub> hydrogen bond between <b>btfa</b> and acceptor molecules, while in the one remaining cocrystal, donor and acceptor molecules are connected via the N–H···N<sub>acceptor</sub> hydrogen bond and the Br···N<sub>acceptor</sub> halogen bond. In two cocrystals of <b>itfa</b>, the dominant supramolecular interaction is the I···N<sub>acceptor</sub> halogen bond between <b>itfa</b> and acceptor molecules, while in the remaining four cocrystals, donor and acceptor molecules are additionally connected by the N–H···N<sub>acceptor</sub> hydrogen bond. Periodic density-functional theory (DFT) calculations have been conducted to assess the formation energies of these cocrystals and the strengths of the established halogen and hydrogen bonds. Molecular DFT calculations on <b>btfa</b> and <b>itfa</b> indicate that the differences in electrostatic potential between the competing sites on the molecules are 261.6 and 157.0 kJ mol<sup>–1</sup> e<sup>–1</sup>, respectively. The findings suggest that <b>itfa</b>, with a smaller electrostatic potential difference between donor sites, is more predisposed to act as a bifunctional donor.</p><p >The experimental and theoretical capability of two perhalogenated anilines, 2,3,5,6-tetrafluoro-4-bromoaniline and 2,3,5,6-tetrafluoro-4-iodoaniline, as hydrogen and halogen bond donors have been explored by cocrystallization with 4,4′-bipyridine, 1,2-bis(4-pyridyl)ethane, and 1,4-diazabicyclo[2.2.2]octane.</p>","PeriodicalId":34,"journal":{"name":"Crystal Growth & Design","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acs.cgd.4c00315","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141379652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mono- and bis-carbonyl hypoiodites incorporating the tertiary amines quinuclidine (1a–e) or 1,4-diazabicyclo[2.2.2]octane (DABCO; 2a, 2b, and 2e), respectively, have been synthesized and represent the first examples of hypoiodites stabilized by alkyl amines rather than aromatic Lewis bases (e.g., pyridine derivatives). These highly reactive complexes have been characterized in the solid state by SCXRD and DFT calculations. The DABCO hypoiodite derivatives are rare examples of ditopic bis(O–I–N) complexes and were found to display unexpected bonding parameters relative to iodine(I) complexes in which the DABCO is coordinating in a monotopic manner.
Mono- and bis-carbonyl hypoiodites incorporating the tertiary amines quinuclidine or 1,4-diazabicyclo[2.2.2]octane have been synthesized and represent the first examples of hypoiodites stabilized by alkyl amines rather than aromatic Lewis bases.
{"title":"Mono- and Bis-Carbonyl Hypoiodites of the Tertiary Amines Quinuclidine and DABCO","authors":"Shilin Yu, Kari Rissanen* and Jas S. Ward*, ","doi":"10.1021/acs.cgd.4c00377","DOIUrl":"10.1021/acs.cgd.4c00377","url":null,"abstract":"<p ><i>Mono</i>- and <i>bis</i>-carbonyl hypoiodites incorporating the tertiary amines quinuclidine (<b>1a</b>–<b>e</b>) or 1,4-diazabicyclo[2.2.2]octane (DABCO; <b>2a</b>, <b>2b</b>, and <b>2e</b>), respectively, have been synthesized and represent the first examples of hypoiodites stabilized by alkyl amines rather than aromatic Lewis bases (e.g., pyridine derivatives). These highly reactive complexes have been characterized in the solid state by SCXRD and DFT calculations. The DABCO hypoiodite derivatives are rare examples of ditopic <i>bis</i>(O–I–N) complexes and were found to display unexpected bonding parameters relative to iodine(I) complexes in which the DABCO is coordinating in a monotopic manner.</p><p ><i>Mono</i>- and <i>bis</i>-carbonyl hypoiodites incorporating the tertiary amines quinuclidine or 1,4-diazabicyclo[2.2.2]octane have been synthesized and represent the first examples of hypoiodites stabilized by alkyl amines rather than aromatic Lewis bases.</p>","PeriodicalId":34,"journal":{"name":"Crystal Growth & Design","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acs.cgd.4c00377","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141379644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shaheen Sultana, Rajorshi Mandal and Kumar Biradha*,
Coordination polymers serve as an important platform to promote highly selective solid-state reactions between organic struts. A new class of amide-containing cyclobutane molecules has been synthesized using a [2 + 2] photodimerization reaction in coordination polymers (CPs) of rigid and linear diene 3,3′-(1,4-phenylene)bis(N-(3-pyridyl)acrylamide), 4PMA, with rigid as well as flexible dicarboxylates as coligands. Four Co(II) CPs studied here produce 2D layers with rhomboidal grids (isophthalate (CP-1) and p-carboxy cinnamate (CP-2)), while p-phenylene acrylate (CP-3) yields a 3D framework with cds topology and p-phenylene diacetate forms 2D layers with a bimetallic secondary building unit (SBU). The [2 + 2] cycloaddition reaction upon exposure to 365 nm UV light on the methanol solvate of 4PMA remained elusive despite a favorable polymeric alignment in its crystal structure. Single crystals of CPs upon irradiation resulted in photodimerization; however, the crystal structure suggests polymerization (CP-1 and CP-2) or no reaction (CP-3). This unusual behavior is attributed to deviations in geometrical parameters from the ideal, serving as the driving force behind the photodimerization reaction. Nevertheless, the 2D CP of CP-4 exhibited resilience during dimerization, leading to the formation of a 3D coordination polymer of the fsc net of CP-4P through a single-crystal-to-single-crystal structural transformation. The separated dimer product displays quenched photoluminescence and blue-shifted spectra compared with the monomer.
{"title":"Exploration of Solid-State [2 + 2] Photodimerization in the Coordination Polymers of Rigid and Linear Diene: Single-Crystal-to-Single-Crystal Transformation of a 2D Coordination Polymer to a 3D Coordination Polymer","authors":"Shaheen Sultana, Rajorshi Mandal and Kumar Biradha*, ","doi":"10.1021/acs.cgd.4c00614","DOIUrl":"10.1021/acs.cgd.4c00614","url":null,"abstract":"<p >Coordination polymers serve as an important platform to promote highly selective solid-state reactions between organic struts. A new class of amide-containing cyclobutane molecules has been synthesized using a [2 + 2] photodimerization reaction in coordination polymers (CPs) of rigid and linear diene 3,3′-(1,4-phenylene)bis(<i>N</i>-(3-pyridyl)acrylamide), <b>4PMA</b>, with rigid as well as flexible dicarboxylates as coligands. Four Co(II) CPs studied here produce 2D layers with rhomboidal grids (isophthalate (<b>CP-1</b>) and <i>p</i>-carboxy cinnamate (<b>CP-2</b>)), while <i>p</i>-phenylene acrylate (<b>CP-3</b>) yields a 3D framework with <b>cds</b> topology and <i>p</i>-phenylene diacetate forms 2D layers with a bimetallic secondary building unit (SBU). The [2 + 2] cycloaddition reaction upon exposure to 365 nm UV light on the methanol solvate of <b>4PMA</b> remained elusive despite a favorable polymeric alignment in its crystal structure. Single crystals of CPs upon irradiation resulted in photodimerization; however, the crystal structure suggests polymerization (<b>CP-1</b> and <b>CP-2</b>) or no reaction (<b>CP-3</b>). This unusual behavior is attributed to deviations in geometrical parameters from the ideal, serving as the driving force behind the photodimerization reaction. Nevertheless, the 2D CP of <b>CP-4</b> exhibited resilience during dimerization, leading to the formation of a 3D coordination polymer of the <b>fsc</b> net of <b>CP-4P</b> through a single-crystal-to-single-crystal structural transformation. The separated dimer product displays quenched photoluminescence and blue-shifted spectra compared with the monomer.</p>","PeriodicalId":34,"journal":{"name":"Crystal Growth & Design","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141259333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Meritxell Toda-Casaban*, Carlos Frontera, Alberto Pomar, Javier Herrero-Martín, José Antonio Alonso, Lluís Balcells, Narcís Mestres and Benjamín Martínez,
Epitaxial thin films of the La1–xSrxMnO3 system, spanning a wide range of compositions (0.5 ≤ x ≤ 0.65), have been prepared, using the polymer-assisted deposition method, on SrTiO3 (100) substrates. The primary objective was to achieve the highly stable A-type antiferromagnetic (AF) phase associated with x = 0.5. However, the electronic and magnetic properties of the samples, with different substitution levels of La with Sr, exhibit deviations from the anticipated behavior according to the bulk phase diagram. Employing X-ray absorption spectroscopy, we demonstrate that the effective 0.5:0.5 ratio of Mn3+:Mn4+ is actually attained in the sample with x = 0.65, suggesting the presence of an alternative charge compensation mechanism. High oxygen pressure annealing processes allow us to demonstrate that oxygen vacancies, generated to accommodate the epitaxial structural strain, are responsible for the partial charge compensation and the observed deviations from the bulk phase diagram.
Epitaxial thin films of the La1−xSrxMnO3 system (0.5 ≤ x ≤ 0.65) have been prepared by PAD to achieve the A-type antiferromagnetic (AF) phase (x = 0.5). However, the samples show deviations from the bulk phase diagram, and this AF phase is found for x = 0.65, according to XAS. The presence of oxygen vacancies can justify these results.
利用聚合物辅助沉积法,在 SrTiO3 (100) 基底上制备了 La1-xSrxMnO3 系统的外延薄膜,其成分范围很广(0.5 ≤ x ≤ 0.65)。其主要目的是获得与 x = 0.5 相关的高度稳定的 A 型反铁磁(AF)相。然而,根据体相图,样品的电子和磁性能在 La 与 Sr 的不同替代水平下表现出与预期行为的偏差。利用 X 射线吸收光谱,我们证明了在 x = 0.65 的样品中,Mn3+:Mn4+ 的有效比例实际上达到了 0.5:0.5,这表明存在另一种电荷补偿机制。高氧压退火过程使我们能够证明,为适应外延结构应变而产生的氧空位是部分电荷补偿和观察到的体相图偏差的原因。
{"title":"Tuning of Antiferromagnetic Phase in La1–xSrxMnO3 Epitaxial Thin Films by Polymer-Assisted Deposition Synthesis","authors":"Meritxell Toda-Casaban*, Carlos Frontera, Alberto Pomar, Javier Herrero-Martín, José Antonio Alonso, Lluís Balcells, Narcís Mestres and Benjamín Martínez, ","doi":"10.1021/acs.cgd.4c00229","DOIUrl":"10.1021/acs.cgd.4c00229","url":null,"abstract":"<p >Epitaxial thin films of the La<sub>1–<i>x</i></sub>Sr<sub><i>x</i></sub>MnO<sub>3</sub> system, spanning a wide range of compositions (0.5 ≤ <i>x</i> ≤ 0.65), have been prepared, using the polymer-assisted deposition method, on SrTiO<sub>3</sub> (100) substrates. The primary objective was to achieve the highly stable A-type antiferromagnetic (AF) phase associated with <i>x</i> = 0.5. However, the electronic and magnetic properties of the samples, with different substitution levels of La with Sr, exhibit deviations from the anticipated behavior according to the bulk phase diagram. Employing X-ray absorption spectroscopy, we demonstrate that the effective 0.5:0.5 ratio of Mn<sup>3+</sup>:Mn<sup>4+</sup> is actually attained in the sample with <i>x</i> = 0.65, suggesting the presence of an alternative charge compensation mechanism. High oxygen pressure annealing processes allow us to demonstrate that oxygen vacancies, generated to accommodate the epitaxial structural strain, are responsible for the partial charge compensation and the observed deviations from the bulk phase diagram.</p><p >Epitaxial thin films of the La<sub>1−<i>x</i></sub>Sr<sub><i>x</i></sub>MnO<sub>3</sub> system (0.5 ≤ <i>x</i> ≤ 0.65) have been prepared by PAD to achieve the A-type antiferromagnetic (AF) phase (<i>x</i> = 0.5). However, the samples show deviations from the bulk phase diagram, and this AF phase is found for <i>x</i> = 0.65, according to XAS. The presence of oxygen vacancies can justify these results.</p>","PeriodicalId":34,"journal":{"name":"Crystal Growth & Design","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acs.cgd.4c00229","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141259450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michele Prencipe, Paolo P. Mazzeo*, Riccardo Montis, Bruno Famiani, Giuditta Cicconi and Alessia Bacchi*,
Azo-pyridinic derivatives are renowned for their ability to undergo reversible molecular switching when exposed to light. By combining the photoresponsive properties of azo-benzene with the supramolecular capabilities of pyridyl groups, azo-pyridines offer a route to develop multifunctional responsive materials through noncovalent interactions or reversible chemical reactions. Although azo-pyridine and its derivatives are commonly used in crystal engineering, their spectroscopic characterization is typically limited in solution and only poor attention has been given to their photoresponsive behavior in the solid state. Here, we present a library of azo-pyridinic derivatives designed as potential photoresponsive compounds with different spectroscopic behaviors based on the chemical decoration of the phenyl ring. Comprehensive characterization, including crystal structure, thermal analysis, and spectroscopic analysis, was performed for all compounds. Finally, their trans-to-cis isomerization propensity in the solid state is correlated with their crystal structures.
{"title":"Design of a Library of Azo-pyridinic Derivatives as Building Blocks for Photoresponsive Materials","authors":"Michele Prencipe, Paolo P. Mazzeo*, Riccardo Montis, Bruno Famiani, Giuditta Cicconi and Alessia Bacchi*, ","doi":"10.1021/acs.cgd.4c00380","DOIUrl":"10.1021/acs.cgd.4c00380","url":null,"abstract":"<p >Azo-pyridinic derivatives are renowned for their ability to undergo reversible molecular switching when exposed to light. By combining the photoresponsive properties of azo-benzene with the supramolecular capabilities of pyridyl groups, azo-pyridines offer a route to develop multifunctional responsive materials through noncovalent interactions or reversible chemical reactions. Although azo-pyridine and its derivatives are commonly used in crystal engineering, their spectroscopic characterization is typically limited in solution and only poor attention has been given to their photoresponsive behavior in the solid state. Here, we present a library of azo-pyridinic derivatives designed as potential photoresponsive compounds with different spectroscopic behaviors based on the chemical decoration of the phenyl ring. Comprehensive characterization, including crystal structure, thermal analysis, and spectroscopic analysis, was performed for all compounds. Finally, their <i>trans</i>-to-<i>cis</i> isomerization propensity in the solid state is correlated with their crystal structures.</p>","PeriodicalId":34,"journal":{"name":"Crystal Growth & Design","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141259619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Detailed crystallographic and computational analysis of solvates of dasatinib (DAS), an inhibitor of multiple tyrosine kinases, was performed by confirming the high structural similarity of most of the DAS crystal structures and identifying the differences in molecular conformation, hydrogen bonding, and molecular packing. The crystal structures of 14 new DAS solvates are presented, allowing the crystallographic analysis of 23 DAS solvates and one nonsolvated phase. The analysis of molecular conformation revealed that in most of the structures DAS adopts three slightly different conformations, even though computational analysis indicated the existence of alternative energetically competitive conformations. In almost all structures, DAS molecules form identical hydrogen-bonded layers. The lack of structural variation is believed to be the result of the limited ways for efficient packing of the large sized and specifically shaped DAS molecules. Detailed analysis, however, revealed three similar but somewhat different ways these layers are packed, resulting in the classification of DAS solvates in three structure groups I, II, and III. The different arrangements of the layers result in different hydrogen bonds formed by O1–H and the space available for the solvent, but, interestingly, this is not linked with the exact DAS conformation or solvent functionality, properties, or bonding with DAS molecules.
对多种酪氨酸激酶抑制剂达沙替尼(DAS)的溶胶进行了详细的晶体学和计算分析,确认了大多数 DAS 晶体结构的高度相似性,并确定了分子构象、氢键和分子堆积的差异。该研究展示了 14 种新的 DAS 溶剂的晶体结构,从而对 23 种 DAS 溶剂和一种非溶解相进行了晶体学分析。对分子构象的分析表明,在大多数结构中,DAS 采用了三种略有不同的构象,尽管计算分析表明存在其他能量竞争性构象。在几乎所有结构中,DAS 分子都形成了相同的氢键层。结构缺乏变化被认为是由于大尺寸和特殊形状的 DAS 分子有效堆积的途径有限。然而,详细分析发现,这些层的堆积方式有三种相似但略有不同的方式,因此将 DAS 溶剂分为 I、II 和 III 三个结构组。层的不同排列方式导致 O1-H 形成的氢键和溶剂的可用空间不同,但有趣的是,这与 DAS 的确切构象或溶剂的功能、特性或与 DAS 分子的结合并无关联。
{"title":"Similarity and Differences of Dasatinib Solvates: A Crystallographic Perspective","authors":"Aija Trimdale-Deksne, Ilze Grante, Anatoly Mishnev*, Lia̅na Orola and Agris Be̅rziṇš*, ","doi":"10.1021/acs.cgd.4c00248","DOIUrl":"10.1021/acs.cgd.4c00248","url":null,"abstract":"<p >Detailed crystallographic and computational analysis of solvates of dasatinib (DAS), an inhibitor of multiple tyrosine kinases, was performed by confirming the high structural similarity of most of the DAS crystal structures and identifying the differences in molecular conformation, hydrogen bonding, and molecular packing. The crystal structures of 14 new DAS solvates are presented, allowing the crystallographic analysis of 23 DAS solvates and one nonsolvated phase. The analysis of molecular conformation revealed that in most of the structures DAS adopts three slightly different conformations, even though computational analysis indicated the existence of alternative energetically competitive conformations. In almost all structures, DAS molecules form identical hydrogen-bonded layers. The lack of structural variation is believed to be the result of the limited ways for efficient packing of the large sized and specifically shaped DAS molecules. Detailed analysis, however, revealed three similar but somewhat different ways these layers are packed, resulting in the classification of DAS solvates in three structure groups I, II, and III. The different arrangements of the layers result in different hydrogen bonds formed by O1–H and the space available for the solvent, but, interestingly, this is not linked with the exact DAS conformation or solvent functionality, properties, or bonding with DAS molecules.</p>","PeriodicalId":34,"journal":{"name":"Crystal Growth & Design","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141259370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hui-Min Tang, Zheng-Yang Quan, Bo Ding, Xiu-Guang Wang, Bo Tang, Zheng-Guo Huang* and En-Cui Yang*,
Molecular crystals with desirable structures and tunable photoluminescence are highly important for multiscenario field applications as lasers, sensors, and light-emitting devices. However, purposeful controls on the photoluminescence are still challenging because of the high sensitivity of molecular stackings to molecular structures and surroundings. Herein, solid-state assembly and photoluminescent behavior of nine 5-(9H-carbazol-9-yl) isophthalic acid (CzIp)-based molecular crystals have been crystallographically, spectroscopically, and theoretically investigated by incorporation with electron-deficient acceptors and polar solvent molecules. As compared to the self-aggregation of green-emissive CzIp, methanol-solvated CzIp-CH3OH and hydrated CzIp-H2O exhibit tailorable structural overlaps for the π-stacked CzIp–CzIp dimers, emitting high-energy cyan and blue fluorescence upon excitation by UV light. These blue-shifted emissions are from different local excited states of the π-stacked dimers. By contrast, six cocrystals with 1:1 and 2:1 stoichiometry and/or cocrystallized solvent are constructed, respectively, from the π–π stacked CzIp-acceptor or CzIp–CzIp pairs, which are assembled into one-dimensional ribbons (for CzIp-OFN, CzIp-TCNB, CzIp-DCTFB, and CzIp-TCNQ, OFN = octafluoronaphthalene, TCNB = 1,2,4,5-tetracyanobenzene, DCTFB = 2,3,5,6-tetrafluoro-1,4-dicyanobenzene, and TCNQ = 7,7,8,8-tetracyanoquinodimethane), two-dimensional sheet (for CzIp-DITFB, DITFB = 1,4-diiodotetrafluorobenzene), and discrete cyclic tetramer (for CzIp-TND, TND = 1,4,5,8-naphthalenetetracarboxdiimide) through intermolecular hydrogen- and halogen-bonding interactions. These cocrystals emit switchable emissions from quenched fluorescence to intense blue, green, orange, and near-infrared photoluminescence. Further structural comparisons and theoretical calculations demonstrate that the wide-range multicolor luminescence is either from the local excited state or from the charge transfer, in which the π-stacked donor–acceptor pair, suitable energy levels, and band gap, as well as rational hole–electron distributions, manipulate synergistically the charge transfer-induced photoluminescence. These findings offer in-depth insights into the relationships of molecular stackings and photoluminescence, advancing the development of organic luminescence crystals with desirable optoelectronic properties.
{"title":"Solid-State Assembly and Photoluminescent Behavior of 5-(9H-Carbazol-9-yl)isophthalic Acid–Based Molecular Crystals Influenced by Solvents and Organic Counterparts","authors":"Hui-Min Tang, Zheng-Yang Quan, Bo Ding, Xiu-Guang Wang, Bo Tang, Zheng-Guo Huang* and En-Cui Yang*, ","doi":"10.1021/acs.cgd.4c00446","DOIUrl":"10.1021/acs.cgd.4c00446","url":null,"abstract":"<p >Molecular crystals with desirable structures and tunable photoluminescence are highly important for multiscenario field applications as lasers, sensors, and light-emitting devices. However, purposeful controls on the photoluminescence are still challenging because of the high sensitivity of molecular stackings to molecular structures and surroundings. Herein, solid-state assembly and photoluminescent behavior of nine 5-(9H-carbazol-9-yl) isophthalic acid (CzIp)-based molecular crystals have been crystallographically, spectroscopically, and theoretically investigated by incorporation with electron-deficient acceptors and polar solvent molecules. As compared to the self-aggregation of green-emissive <b>CzIp</b>, methanol-solvated <b>CzIp-CH</b><sub><b>3</b></sub><b>OH</b> and hydrated <b>CzIp-H</b><sub><b>2</b></sub><b>O</b> exhibit tailorable structural overlaps for the π-stacked CzIp–CzIp dimers, emitting high-energy cyan and blue fluorescence upon excitation by UV light. These blue-shifted emissions are from different local excited states of the π-stacked dimers. By contrast, six cocrystals with 1:1 and 2:1 stoichiometry and/or cocrystallized solvent are constructed, respectively, from the π–π stacked CzIp-acceptor or CzIp–CzIp pairs, which are assembled into one-dimensional ribbons (for <b>CzIp-OFN, CzIp-TCNB</b>, <b>CzIp-DCTFB</b>, and <b>CzIp-TCNQ</b>, OFN = octafluoronaphthalene, TCNB = 1,2,4,5-tetracyanobenzene, DCTFB = 2,3,5,6-tetrafluoro-1,4-dicyanobenzene, and TCNQ = 7,7,8,8-tetracyanoquinodimethane), two-dimensional sheet (for <b>CzIp-DITFB,</b> DITFB = 1,4-diiodotetrafluorobenzene), and discrete cyclic tetramer (for <b>CzIp-TND</b>, TND = 1,4,5,8-naphthalenetetracarboxdiimide) through intermolecular hydrogen- and halogen-bonding interactions. These cocrystals emit switchable emissions from quenched fluorescence to intense blue, green, orange, and near-infrared photoluminescence. Further structural comparisons and theoretical calculations demonstrate that the wide-range multicolor luminescence is either from the local excited state or from the charge transfer, in which the π-stacked donor–acceptor pair, suitable energy levels, and band gap, as well as rational hole–electron distributions, manipulate synergistically the charge transfer-induced photoluminescence. These findings offer in-depth insights into the relationships of molecular stackings and photoluminescence, advancing the development of organic luminescence crystals with desirable optoelectronic properties.</p>","PeriodicalId":34,"journal":{"name":"Crystal Growth & Design","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141259620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
William W. L. Ho, Jefferson A. Pells and Daniel B. Leznoff*,
The synthesis and solid-state structures of four structurally diverse i-mnt-based anionic complexes and coordination polymers are described (i-mnt = iso-maleonitrile dithiolate). (nPr4N)4[Pb2(i-mnt)4] is dimeric, containing a five-coordinate distorted square pyramidal Pb(II) center with a stereochemically active lone pair. The isoelectronic (nPr4N)[Bi(i-mnt)2] is a distorted six-coordinate complex that crystallizes in the polar P21 space group and forms a 2D coordination polymer via intermolecular Bi–N interactions; the d10s2 Bi(III) center also has a hemidirectional coordination sphere with a stereochemically active lone pair. Using the more compact (Me4N)+ cation, (Me4N)2[Pb(i-mnt)2] contains eight-coordinate holodirectional Pb(II) centers that form 1D chains via bridging Pb–S bonding. These anionic complexes could provide the foundation to incorporate stereochemically active lone pairs into heterometallic coordination polymers. As a comparison, (nPr4N)3Cr(i-mnt)3·H2O was also prepared and has a propeller structure with a typical octahedral Cr(III) center.
{"title":"Structural Diversity of Iso-Maleonitrile Dithiolate d10s2 Metal Complexes of Lead and Bismuth","authors":"William W. L. Ho, Jefferson A. Pells and Daniel B. Leznoff*, ","doi":"10.1021/acs.cgd.4c00331","DOIUrl":"10.1021/acs.cgd.4c00331","url":null,"abstract":"<p >The synthesis and solid-state structures of four structurally diverse <i>i</i>-mnt-based anionic complexes and coordination polymers are described (<i>i</i>-mnt = <i>iso</i>-maleonitrile dithiolate). (<sup>n</sup>Pr<sub>4</sub>N)<sub>4</sub>[Pb<sub>2</sub>(<i>i</i>-mnt)<sub>4</sub>] is dimeric, containing a five-coordinate distorted square pyramidal Pb(II) center with a stereochemically active lone pair. The isoelectronic (<sup>n</sup>Pr<sub>4</sub>N)[Bi(<i>i</i>-mnt)<sub>2</sub>] is a distorted six-coordinate complex that crystallizes in the polar P2<sub>1</sub> space group and forms a 2D coordination polymer via intermolecular Bi–N interactions; the d<sup>10</sup>s<sup>2</sup> Bi(III) center also has a hemidirectional coordination sphere with a stereochemically active lone pair. Using the more compact (Me<sub>4</sub>N)<sup>+</sup> cation, (Me<sub>4</sub>N)<sub>2</sub>[Pb(<i>i</i>-mnt)<sub>2</sub>] contains eight-coordinate holodirectional Pb(II) centers that form 1D chains via bridging Pb–S bonding. These anionic complexes could provide the foundation to incorporate stereochemically active lone pairs into heterometallic coordination polymers. As a comparison, (<sup>n</sup>Pr<sub>4</sub>N)<sub>3</sub>Cr(<i>i</i>-mnt)<sub>3</sub>·H<sub>2</sub>O was also prepared and has a propeller structure with a typical octahedral Cr(III) center.</p>","PeriodicalId":34,"journal":{"name":"Crystal Growth & Design","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141259368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tom E. de Vries, Evi van Eert, Lucas Weevers, Paul Tinnemans, Elias Vlieg, Hugo Meekes and René de Gelder*,
The physicochemical properties of chemical compounds can be altered and optimized by cocrystallization with a suitable coformer. However, discovering suitable coformers is a difficult and expensive process. Link prediction is one of the several techniques developed to predict suitable new coformers computationally. Link prediction uses a network of known coformers extracted from, e.g., the Cambridge Structural Database (CSD) to predict new cocrystals. We have investigated link prediction methods and were able to improve the performance of these methods using a scoring function called “multi-steps resource allocation”. Further improvements were obtained by examining the local structure of the network to remove imperfections and by using an algorithm previously designed by us to bipartise the network, thus removing imperfections on a global scale. By repeatedly predicting and synthesizing new cocrystals and adding them to the network to predict more new cocrystals, we obtain more and better predictions, but saturation of the local network eventually leads to diminishing returns. We demonstrate this for praziquantel (PZQ), a drug used to treat schistosomiasis. We discovered 11 new cocrystals for this compound, one of which is a racemic conglomerate that could be used to improve the medical efficacy of PZQ, and present 6 new cocrystal structures.
Link prediction for the CSD cocrystal network is optimized and iteratively applied to praziquantel.
{"title":"Optimizing Link Prediction for the CSD Cocrystal Network: A Demonstration Using Praziquantel","authors":"Tom E. de Vries, Evi van Eert, Lucas Weevers, Paul Tinnemans, Elias Vlieg, Hugo Meekes and René de Gelder*, ","doi":"10.1021/acs.cgd.4c00438","DOIUrl":"10.1021/acs.cgd.4c00438","url":null,"abstract":"<p >The physicochemical properties of chemical compounds can be altered and optimized by cocrystallization with a suitable coformer. However, discovering suitable coformers is a difficult and expensive process. Link prediction is one of the several techniques developed to predict suitable new coformers computationally. Link prediction uses a network of known coformers extracted from, e.g., the Cambridge Structural Database (CSD) to predict new cocrystals. We have investigated link prediction methods and were able to improve the performance of these methods using a scoring function called “multi-steps resource allocation”. Further improvements were obtained by examining the local structure of the network to remove imperfections and by using an algorithm previously designed by us to bipartise the network, thus removing imperfections on a global scale. By repeatedly predicting and synthesizing new cocrystals and adding them to the network to predict more new cocrystals, we obtain more and better predictions, but saturation of the local network eventually leads to diminishing returns. We demonstrate this for praziquantel (PZQ), a drug used to treat schistosomiasis. We discovered 11 new cocrystals for this compound, one of which is a racemic conglomerate that could be used to improve the medical efficacy of PZQ, and present 6 new cocrystal structures.</p><p >Link prediction for the CSD cocrystal network is optimized and iteratively applied to praziquantel.</p>","PeriodicalId":34,"journal":{"name":"Crystal Growth & Design","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acs.cgd.4c00438","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141259367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}