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Diagnósticos e assistência do enfermeiro em oncologia pediátrica 儿科肿瘤学的诊断和护理协助
Q1 Arts and Humanities Pub Date : 2022-11-10 DOI: 10.20396/ccfenf220224744
Gisele Vieira de Carvalho Luz, A. D. A. E. Silva
Introdução: No âmbito do câncer infantil, o profissional de enfermagem realiza um cuidado direcionado e humanizado, onde articula saberes e práticas para assistência. Objetivos: Descrever a atuação do enfermeiro na assistência oncológica pediátrica. Identificar os principais diagnósticos de enfermagem. Método: Trata-se de uma revisão integrativa da literatura por meio das bases de dados: LILACS, BDENF e biblioteca eletrônica SciELO. Foram selecionados artigos de 2012 a 2022, utilizando os seguintes descritores: Oncologia, Enfermeiros, Diagnóstico de Enfermagem, Cuidados de Enfermagem e Cuidado da Criança. A amostra final foi constituída de nove artigos no idioma português. Resultados: A atuação do enfermeiro na oncologia pediátrica exige habilidades de empatia e criação de vínculo com a criança e sua família, usando do conhecimento técnico científico para orientar sobre a doença e minimizar os estigmas referentes ao câncer, sendo necessário o equilíbrio emocional, pois nem sempre o tratamento apresenta um resultado positivo. A liderança e a comunicação efetiva com a equipe são fundamentais na qualidade do tratamento, na redução do estresse, promoção do bem-estar, relacionamento interpessoal e gestão emocional. Para proporcionar bem-estar a criança, o enfermeiro deve inserir o lúdico na sua assistência, possibilitando o conforto durante a internação. Os principais diagnósticos de enfermagem identificados são: Risco de infecção, dor aguda, dor crônica, conforto prejudicado, integridade da pele prejudicada, risco de lesão por pressão na criança, hipertermia, mucosa oral prejudicada, nutrição desequilibrada: menor do que as necessidades corporais, constipação, medo, ansiedade. Conclusão: O câncer infantil traz ao enfermeiro uma assistência desafiadora, sendo necessária a capacitação deste profissional para a prestação de uma assistência de excelência. A Sistematização de Assistência da Enfermagem torna-se de suma importância para que, conforme a necessidade de cada qual, seja aplicado um tratamento individualizado com base nos diagnósticos de enfermagem, proporcionando uma assistência humanizada e prezando o bem-estar da criança.
简介:在儿童癌症的背景下,护理专业人员进行有针对性和人性化的护理,明确知识和实践的援助。目的:描述护士在儿科肿瘤护理中的作用。确定主要的护理诊断。方法:采用紫丁香、BDENF和SciELO电子图书馆数据库进行综合文献综述。选取2012 - 2022年的文章,使用以下关键词:肿瘤学、护士、护理诊断、护理和儿童护理。最后的样本包括九篇葡萄牙语文章。结果:护士在儿科肿瘤学的性能要求的同情和创建链接和那孩子和他的家人,用科学技术的指导和最少的圣痕的身体情况cancer,平衡情绪,因为一直是处理一个积极的结果。领导能力和与团队的有效沟通对于治疗质量、减轻压力、促进健康、人际关系和情绪管理至关重要。为了给孩子提供福利,护士必须在他的帮助中加入好玩的东西,使住院期间感到舒适。确定的主要护理诊断有:感染风险、急性疼痛、慢性疼痛、舒适度受损、皮肤完整性受损、儿童压力损伤风险、体温过高、口腔黏膜受损、营养不平衡:低于身体需求、便秘、恐惧、焦虑。结论:儿童癌症给护士带来了具有挑战性的护理,需要对该专业人员进行培训,以提供卓越的护理。系统化的护理护理变得非常重要,根据每个人的需要,应用基于护理诊断的个性化治疗,提供人性化的护理,重视孩子的福祉。
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引用次数: 0
VIII— Intrinsically Desiring the Vague VIII-本质渴望模糊
Q1 Arts and Humanities Pub Date : 2022-07-25 DOI: 10.1093/arisoc/aoac006
Jack Spencer
If there are vague propositions, then the question arises whether it is rational to care intrinsically about the vague. This paper argues—contra  Bacon (2018), the most comprehensive defence of vague proposition to date—that it is. Some things, such as pain, may be rational to care intrinsically about only if precise, but some things, such as truth, are rational to care intrinsically about even if vague.
如果存在模糊的命题,那么问题就来了,从本质上关心模糊的命题是否合理。这篇论文与培根(2018)相反,培根是迄今为止对模糊命题最全面的辩护。有些事情,如痛苦,只有在精确的情况下,才可能是理性的,而有些事情,例如真理,即使模糊,也是理性的。
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引用次数: 0
VII— Reflecting, Registering, Recording and Representing: From Light Image to Photographic Picture 反思、记录、记录与再现:从光像到摄影画面
Q1 Arts and Humanities Pub Date : 2022-07-22 DOI: 10.1093/arisoc/aoac008
Dawn M Wilson
Photography is valued as a medium for recording and visually reproducing features of the world. I seek to challenge the view that photography is fundamentally a recording process and that every photograph is a record—a view that I claim is based on a ‘single-stage’ misconception of the process. I propose an alternative, ‘multi-stage’ account in which I argue that causal registration of light is not equivalent to recording and reproducing an image. Intervention or non-intervention by photographers is more sophisticated than the traditional view allows. Using the multi-stage account, I describe four models for producing photographic images and pictures.
摄影作为一种记录和视觉再现世界特征的媒介而受到重视。我试图挑战这样一种观点,即摄影从根本上说是一个记录过程,每张照片都是一个记录——我认为这种观点是基于对摄影过程的“单一阶段”误解。我提出了另一种“多阶段”解释,其中我认为光的因果登记不等同于记录和再现图像。摄影师的干预或不干预比传统视角所允许的更为复杂。运用多阶段理论,描述了摄影图像和图片的四种生产模式。
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引用次数: 2
VI—Aesthetic Beautification VI-Aesthetic美化
Q1 Arts and Humanities Pub Date : 2022-07-12 DOI: 10.1093/arisoc/aoac007
Andrew Huddleston
Aesthetic beautification is a familiar artistic phenomenon. Even as they face death, heroes and heroines in operas still sing glorious music. Characters in Shakespearean tragedies still deliver beautifully eloquent speeches in the throes of despair. Even when depicting suffering and horror, paintings can still remain a transfixing delight for the eyes. In such cases, the work of art represents or expresses something to which we would, in ordinary life, attribute a negative valence (suffering, horror, death, and the like), but it does so beautifully. Doubtless there is not a single explanation for what transpires in art of this sort or in our experience of it. With some aesthetically beautified art, its foremost goal might be giving aesthetic pleasure, and the beauty of the aesthetic form, even when depicting horrors, is in the service of this primary aim. In other art, the beautification might seek to be jarring and thought-provoking, highlighting a disconnect between the aesthetic frame and what is portrayed. These routes explain much of aesthetic beautification. But I am particularly interested in considering another, still more specific, response: finding ourselves somehow consoled by the beautification. I begin with some reflections on aesthetic beautification in general, and then turn to consider how beautification and consolation might be connected, and what to make of this.
审美美化是一种常见的艺术现象。歌剧中的男女主人公即使面对死亡,仍然唱着光荣的音乐。莎士比亚悲剧中的人物在绝望的阵痛中仍然能发表优美动人的演说。即使描绘痛苦和恐怖,绘画仍然可以保持一种令人目眩的喜悦的眼睛。在这种情况下,艺术作品代表或表达了一些我们在日常生活中会赋予负面价值的东西(痛苦、恐怖、死亡等),但它表现得如此美丽。毫无疑问,对于这类艺术或我们对它的体验中所发生的事情,没有一个单一的解释。对于一些经过美学美化的艺术,其首要目标可能是给予审美愉悦,而美学形式的美,即使是在描绘恐怖的时候,也是为这一主要目标服务的。在其他艺术中,美化可能会寻求不和谐和发人深省,突出审美框架和所描绘的东西之间的脱节。这些路线解释了许多美学美化。但我特别感兴趣的是考虑另一种更具体的反应:发现自己在某种程度上得到了美化的安慰。我从对美学美化的一般思考开始,然后转而考虑美化和安慰如何联系起来,以及如何理解这一点。
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引用次数: 0
Discussion note 讨论说明
Q1 Arts and Humanities Pub Date : 2022-06-25 DOI: 10.1093/arisoc/aoac005
Yohan Molina
In ‘Normative Facts and Reasons’, Fabienne Peter proposes that there are two different types of practical warrant, which she terms ‘entitlement warrant’ and ‘reason-based justification’. This thesis relies fundamentally on her distinction between normative facts and normative reasons. I will raise two general critical observations. First, I will claim that Peter advocates a representation-dependent conception of reasons that is at odds with an intuitive and accepted understanding of them. Second, I will contend that reasons need not be the entities we directly handle in our deliberations, which undermines the idea that reasons are propositions. In this way, her distinction fails: normative reasons are just normative facts. This implies that the existence of two types of practical warrant, based either on normative facts or reasons, is unfounded.
在《规范性事实与理由》一书中,Fabienne Peter提出了两种不同类型的实践授权,她称之为“权利授权”和“基于理由的辩护”。本文从根本上依赖于她对规范性事实和规范性原因的区分。我将提出两个一般性的批评意见。首先,我认为彼得提倡一种依赖表象的理性概念,这与人们对理性的直觉和公认的理解是不一致的。其次,我认为理由不一定是我们在讨论中直接处理的实体,这削弱了理由是命题的观点。这样,她的区分就失败了:规范性原因只是规范性事实。这意味着,基于规范性事实或理由的两种实际保证的存在是没有根据的。
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引用次数: 1
The role of Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) as m6A readers in cancer. 胰岛素样生长因子 2 mRNA 结合蛋白(IGF2BPs)在癌症中作为 m6A 阅读器的作用。
IF 8.2 Q1 Arts and Humanities Pub Date : 2022-03-28 eCollection Date: 2022-01-01 DOI: 10.7150/ijbs.70458
Chao-Yue Sun, Di Cao, Bin-Bin Du, Cun-Wu Chen, Dong Liu

RNA can be modified by over 170 types of distinct chemical modifications, and the most abundant internal modification of mRNA in eukaryotes is N6-methyladenosine (m6A). The m6A modification accelerates mRNA process, including mRNA splicing, translation, transcript stability, export and decay. m6A RNA modification is installed by methyltransferase-like proteins (writers), and potentially removed by demethylases (erasers), and this process is recognized by m6A-binding proteins (readers). Notably, alterations of m6A-modified proteins (writers, erasers and readers) are involved in the tumorigenesis, progression and metastasis. Importantly, the fate of m6A-methylated mRNA is mediated mostly through m6A readers, and among these readers, insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) are unique RNA-binding proteins (RBPs) that stabilize their targets mRNA via m6A modification. In this review, we update the writers, erasers and readers, and their cross-talks in m6A modification, and briefly discuss the oncogenic role of IGF2BPs in cancer. Most importantly, we mainly review the up-to-date knowledges of IGF2BPs (IGF2BP1/2/3) as m6A readers in an m6A-modified manner in cancer progression.

RNA 可被 170 多种不同的化学修饰所修饰,真核生物中最常见的 mRNA 内部修饰是 N6-甲基腺苷(m6A)。m6A 修饰加速了 mRNA 的过程,包括 mRNA 的剪接、翻译、转录本的稳定性、输出和衰变。m6A RNA 修饰由类似甲基转移酶的蛋白(写入者)安装,也可能由去甲基化酶(擦除者)去除,这一过程由 m6A 结合蛋白(阅读者)识别。值得注意的是,m6A修饰蛋白(写入器、清除器和读取器)的改变参与了肿瘤的发生、发展和转移。重要的是,m6A甲基化mRNA的命运主要是通过m6A阅读器介导的,在这些阅读器中,胰岛素样生长因子2 mRNA结合蛋白(IGF2BPs)是一种独特的RNA结合蛋白(RBPs),通过m6A修饰稳定其目标mRNA。在这篇综述中,我们更新了m6A修饰中的书写者、擦除者和阅读者及其交叉关系,并简要讨论了IGF2BPs在癌症中的致癌作用。最重要的是,我们主要回顾了 IGF2BPs(IGF2BP1/2/3)作为 m6A 阅读器以 m6A 修饰方式在癌症进展中的最新知识。
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引用次数: 0
OUP accepted manuscript OUP接受稿件
Q1 Arts and Humanities Pub Date : 2022-01-01 DOI: 10.1093/arisoc/aoac001
{"title":"OUP accepted manuscript","authors":"","doi":"10.1093/arisoc/aoac001","DOIUrl":"https://doi.org/10.1093/arisoc/aoac001","url":null,"abstract":"","PeriodicalId":35222,"journal":{"name":"Proceedings of the Aristotelean Society","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60671979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
OUP accepted manuscript OUP接受稿件
Q1 Arts and Humanities Pub Date : 2022-01-01 DOI: 10.1093/arisoc/aoac003
{"title":"OUP accepted manuscript","authors":"","doi":"10.1093/arisoc/aoac003","DOIUrl":"https://doi.org/10.1093/arisoc/aoac003","url":null,"abstract":"","PeriodicalId":35222,"journal":{"name":"Proceedings of the Aristotelean Society","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60672024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
OUP accepted manuscript OUP接受稿件
Q1 Arts and Humanities Pub Date : 2022-01-01 DOI: 10.1093/arisoc/aoac004
{"title":"OUP accepted manuscript","authors":"","doi":"10.1093/arisoc/aoac004","DOIUrl":"https://doi.org/10.1093/arisoc/aoac004","url":null,"abstract":"","PeriodicalId":35222,"journal":{"name":"Proceedings of the Aristotelean Society","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60672038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
OUP accepted manuscript OUP接受稿件
Q1 Arts and Humanities Pub Date : 2022-01-01 DOI: 10.1093/arisoc/aoac002
{"title":"OUP accepted manuscript","authors":"","doi":"10.1093/arisoc/aoac002","DOIUrl":"https://doi.org/10.1093/arisoc/aoac002","url":null,"abstract":"","PeriodicalId":35222,"journal":{"name":"Proceedings of the Aristotelean Society","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60671989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
期刊
Proceedings of the Aristotelean Society
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