Pub Date : 2020-01-01DOI: 10.5935/1676-2444.20200059
Lucas R. Mostardeiro, E. Antoniolli, J. W. Xavier
ABSTRACT In February 2020, the World Health Organization (WHO) named the infection with the new coronavirus, which appeared in December 2019 in China, as Covid-19, and defined it as a worldwide pandemic There is not much evidence about the relationship between liver disease and Covid-19 Laboratory tests have played a fundamental role in confirming Covid-19, what is usually done by the polymerase chain reaction (PCR) sample The present study reports the laboratory aspects of a patient with type C hepatitis diagnosed with Covid-19 with an unfavorable evolution, devoting special attention to laboratory tests that were almost normal RESUMEN En febrero de 2020, la Organización Mundial de la Salud (OMS) nombró a la infección por el nuevo coronavirus, que surgió en diciembre de 2019 en China, Covid-19, declarándola como pandemia mundial No hay mucha evidencia sobre la relación entre enfermedades hepáticas y la Covid-19 Las pruebas de laboratorio han ocupado un lugar fundamental para confirmar la infección, lo que generalmente se hace por la muestra de reacción en cadena de la polimerasa (PCR) El presente estudio reporta los aspectos de laboratorio de un paciente con hepatitis C y diagnóstico de Covid-19 con evolución desfavorable, llamando la atención sobre pruebas de laboratorio con resultados casi normales RESUMO Em fevereiro de 2020, a Organização Mundial da Saúde (OMS) chamou a infecção pelo novo coronavírus, que surgiu em dezembro de 2019 na China, de COVID-19, definindo-a como pandemia mundial Não há muitas evidências sobre a relação das doenças hepáticas e a COVID-19 Os exames laboratoriais vêm exercendo um papel fundamental na confirmação da infecção, que é feita geralmente pela amostra de reação em cadeia da polimerase (PCR) O presente estudo relata os aspectos laboratoriais de um paciente portador de hepatite do tipo C e diagnóstico de COVID-19 com evolução desfavorável, dando atenção especial para exames laboratoriais que estavam pouco alterados
2020年2月，世界卫生组织(WHO)将2019年12月在中国出现的新型冠状病毒感染命名为Covid-19，并将其定义为全球大流行。关于肝脏疾病与Covid-19之间关系的证据并不多，实验室检测在确认Covid-19方面发挥了重要作用。本研究报告了一名丙型肝炎患者的实验室方面，诊断为Covid-19，发展不利，特别关注实验室检测结果几乎正常resume En febrero de 2020, la Organización Mundial de la Salud (OMS) nombró a la infección por el nuevo coronavirus, que surgió En diciembre de 2019 En China, Covid-19，declarándola como pandemic munil没有太多证据，sobre relación entre enfermedades hepáticas y - Covid-19 Las prebas de laboratorio and ococado unlugar基本参数确认infección, lo que generalgeneralse habeor or laboratesstra de reacción en cadena de la polimerasa (PCR) El提交了研究报告，从多个方面分析了实验室对丙型肝炎的影响diagnóstico de Covid-19 con evolución不利，llamando la atención与正常病例相关的实验室检查结果resume - Em fever ero 2020, who - 卫生组织Saúde (OMS)与卫生组织 (who - 卫生组织)卫生组织(who - 卫生组织)Saúde，与2019 -卫生组织(who - 卫生组织)卫生组织(who - 卫生组织)evidências与卫生组织 (who - 卫生组织)hepáticas与COVID-19相关的实验室检查结果vêm与基本病例确认的卫生组织卫生组织 (who -) hepáticas，(1)在新冠病毒病原学研究中，我们提出了一种新冠病毒病原学研究方法，即在新冠病毒病原学研究中，我们提出了一种新冠病毒病原学研究方法，即在新冠病毒病原学研究中，我们提出了一种新冠病毒病原学研究方法，我们提出了一种新冠病毒病原学研究方法
{"title":"Coronavirus in a patient with hepatitis C: case report","authors":"Lucas R. Mostardeiro, E. Antoniolli, J. W. Xavier","doi":"10.5935/1676-2444.20200059","DOIUrl":"https://doi.org/10.5935/1676-2444.20200059","url":null,"abstract":"ABSTRACT In February 2020, the World Health Organization (WHO) named the infection with the new coronavirus, which appeared in December 2019 in China, as Covid-19, and defined it as a worldwide pandemic There is not much evidence about the relationship between liver disease and Covid-19 Laboratory tests have played a fundamental role in confirming Covid-19, what is usually done by the polymerase chain reaction (PCR) sample The present study reports the laboratory aspects of a patient with type C hepatitis diagnosed with Covid-19 with an unfavorable evolution, devoting special attention to laboratory tests that were almost normal RESUMEN En febrero de 2020, la Organización Mundial de la Salud (OMS) nombró a la infección por el nuevo coronavirus, que surgió en diciembre de 2019 en China, Covid-19, declarándola como pandemia mundial No hay mucha evidencia sobre la relación entre enfermedades hepáticas y la Covid-19 Las pruebas de laboratorio han ocupado un lugar fundamental para confirmar la infección, lo que generalmente se hace por la muestra de reacción en cadena de la polimerasa (PCR) El presente estudio reporta los aspectos de laboratorio de un paciente con hepatitis C y diagnóstico de Covid-19 con evolución desfavorable, llamando la atención sobre pruebas de laboratorio con resultados casi normales RESUMO Em fevereiro de 2020, a Organização Mundial da Saúde (OMS) chamou a infecção pelo novo coronavírus, que surgiu em dezembro de 2019 na China, de COVID-19, definindo-a como pandemia mundial Não há muitas evidências sobre a relação das doenças hepáticas e a COVID-19 Os exames laboratoriais vêm exercendo um papel fundamental na confirmação da infecção, que é feita geralmente pela amostra de reação em cadeia da polimerase (PCR) O presente estudo relata os aspectos laboratoriais de um paciente portador de hepatite do tipo C e diagnóstico de COVID-19 com evolução desfavorável, dando atenção especial para exames laboratoriais que estavam pouco alterados","PeriodicalId":35397,"journal":{"name":"Jornal Brasileiro de Patologia e Medicina Laboratorial","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71117211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.5935/1676-2444.20200012
Joanilson C. M. Santos Júnior, C. Fratelli, Alan Cristian F. Nóbrega, Suzana Cristina Rodrigues, L. Duarte, C. Silva, Jonathan D. Lima, L. Ferreira, D. Freire, V. F. Cipriano, Izabel Cristina R. Silva, Hélia Carla de Souza
Introduction: Cerebrovascular diseases have been associated with several genes. Chromogranin A ( CHGA ) has been used as maker in cardiovascular disease. Therefore, evaluating the polymorphism and verifying its association with this pathology is very important to better understand this disease. Objective: The aim of this study was to identify the association between coding region polymorphism in -264 position of the CHGA gene ( Glu264Asp ) and hemorrhagic stroke (HS)/aneurysm in the Federal District, Brazil. Methods: This is a population-based case-control, involving 45 cases with HS and/or aneurysm. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method is used for genotyping these samples. A significance level of 5% was adopted. Results: The absence of the CC genotype the Glu264Asp CHGA polymorphism in the study participants and the significant presence of the GC heterozygote genotype were observed in this study. However, the distribution of genotypes did not differ statistically in the groups. Conclusion: The Glu264Asp CHGA polymorphism does not seem to contribute to the genesis of the CHGA protein expression in this patients group, but to understand whether or not there is a possible association of the pathology in question and whether the mutation will contribute in the gene therapy and thus to improve patients’ quality of life.
{"title":"Association of the CHGA gene polymorphism in patients with hemorrhagic stroke\u0000 and/or aneurysm","authors":"Joanilson C. M. Santos Júnior, C. Fratelli, Alan Cristian F. Nóbrega, Suzana Cristina Rodrigues, L. Duarte, C. Silva, Jonathan D. Lima, L. Ferreira, D. Freire, V. F. Cipriano, Izabel Cristina R. Silva, Hélia Carla de Souza","doi":"10.5935/1676-2444.20200012","DOIUrl":"https://doi.org/10.5935/1676-2444.20200012","url":null,"abstract":"Introduction: Cerebrovascular diseases have been associated with several genes. Chromogranin A ( CHGA ) has been used as maker in cardiovascular disease. Therefore, evaluating the polymorphism and verifying its association with this pathology is very important to better understand this disease. Objective: The aim of this study was to identify the association between coding region polymorphism in -264 position of the CHGA gene ( Glu264Asp ) and hemorrhagic stroke (HS)/aneurysm in the Federal District, Brazil. Methods: This is a population-based case-control, involving 45 cases with HS and/or aneurysm. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method is used for genotyping these samples. A significance level of 5% was adopted. Results: The absence of the CC genotype the Glu264Asp CHGA polymorphism in the study participants and the significant presence of the GC heterozygote genotype were observed in this study. However, the distribution of genotypes did not differ statistically in the groups. Conclusion: The Glu264Asp CHGA polymorphism does not seem to contribute to the genesis of the CHGA protein expression in this patients group, but to understand whether or not there is a possible association of the pathology in question and whether the mutation will contribute in the gene therapy and thus to improve patients’ quality of life.","PeriodicalId":35397,"journal":{"name":"Jornal Brasileiro de Patologia e Medicina Laboratorial","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71116071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.5935/1676-2444.20200041
Juliana Cristina Magalhães, Leonarda Silvestre Faria de Morais, J. Plewka, M. Turkiewicz, R. Amaral
Introduction: Although the criteria and recommendations are well defined to improve the quality of cervical cytopathology tests (Pap smear) in Brazil, the quality indicators of several laboratories are below the recommended standards. Objective: To evaluate the quality indicators of cervical cytopathology tests carried out by the Brazilian Unified Health System [Sistema Único de Saúde (SUS)]. Method: Cross-sectional study based on the results of cervical cytopathology tests conducted in the municipality of Cascavel, Paraná, Brazil, from January 2012 to December 2018. The study included 141,191 tests and the following variables were analyzed: sample suitability, cervical cytopathology tests result, and internal quality monitoring indicators recommended by the Brazilian Ministry of Health. Results: The percentage of unsatisfactory tests did not exceed 0.97%. The representation of the squamocolumnar junction ranged from 63% to 67.4%. The percentage of altered exams among the satisfactory samples ranged from 0.46% to 6.44%. The positivity index ranged from 0.46% to 6.44%, while the high-grade squamous intraepithelial lesion/satisfactory indicator ranged from 0.21% to 1.06%, atypical squamous cells of undetermined significance/altered ranged from 22.47% to 49.93%, atypical squamous cells of undetermined significance/satisfactory ranged from 0.1% to 2.57%: and atypical squamous cells of undetermined significance/squamous intraepithelial lesions ranged from 0.31 to 1.02. Conclusion: In 2012 and 2013, the high-grade squamous intraepithelial lesion/satisfactory and the positivity index indicators were below the recommended parameters, and in the remaining years, these indicators were within the parameters recommended. Consequently, a greater number of truly cancer precursor lesions were identified, demonstrating the importance of internal quality control in the prevention of cervical cancer.
导言:尽管巴西制定了明确的标准和建议，以提高宫颈细胞病理学检查(巴氏涂片)的质量，但一些实验室的质量指标低于建议的标准。目的:评价巴西统一卫生系统(Sistema Único de Saúde, SUS)宫颈细胞病理学检查的质量指标。方法:基于2012年1月至2018年12月在巴西帕拉纳邦卡斯卡维尔市进行的宫颈细胞病理学检查结果的横断面研究。该研究包括141,191项检测，并分析了以下变量:样本适用性、宫颈细胞病理学检测结果以及巴西卫生部推荐的内部质量监测指标。结果:不合格率不超过0.97%。鳞状柱状连接的代表性为63% ~ 67.4%。在满意的样本中，改试卷的比例从0.46%到6.44%不等。阳性指数范围为0.46% ~ 6.44%，其中高度鳞状上皮内病变/满意指标范围为0.21% ~ 1.06%，意义不明/改变的非典型鳞状细胞范围为22.47% ~ 49.93%，意义不明/满意的非典型鳞状细胞范围为0.1% ~ 2.57%，意义不明的非典型鳞状细胞/鳞状上皮内病变范围为0.31 ~ 1.02。结论:2012年和2013年，高级别鳞状上皮内病变/满意及阳性指标均低于推荐参数，其余年份均在推荐参数范围内。因此，更多的真正的癌症前兆病变被确定，表明内部质量控制在预防宫颈癌的重要性。
{"title":"Evaluation of quality indicators of cervical cytopathology tests carried\u0000 out in a municipality of Paraná, Brazil","authors":"Juliana Cristina Magalhães, Leonarda Silvestre Faria de Morais, J. Plewka, M. Turkiewicz, R. Amaral","doi":"10.5935/1676-2444.20200041","DOIUrl":"https://doi.org/10.5935/1676-2444.20200041","url":null,"abstract":"Introduction: Although the criteria and recommendations are well defined to improve the quality of cervical cytopathology tests (Pap smear) in Brazil, the quality indicators of several laboratories are below the recommended standards. Objective: To evaluate the quality indicators of cervical cytopathology tests carried out by the Brazilian Unified Health System [Sistema Único de Saúde (SUS)]. Method: Cross-sectional study based on the results of cervical cytopathology tests conducted in the municipality of Cascavel, Paraná, Brazil, from January 2012 to December 2018. The study included 141,191 tests and the following variables were analyzed: sample suitability, cervical cytopathology tests result, and internal quality monitoring indicators recommended by the Brazilian Ministry of Health. Results: The percentage of unsatisfactory tests did not exceed 0.97%. The representation of the squamocolumnar junction ranged from 63% to 67.4%. The percentage of altered exams among the satisfactory samples ranged from 0.46% to 6.44%. The positivity index ranged from 0.46% to 6.44%, while the high-grade squamous intraepithelial lesion/satisfactory indicator ranged from 0.21% to 1.06%, atypical squamous cells of undetermined significance/altered ranged from 22.47% to 49.93%, atypical squamous cells of undetermined significance/satisfactory ranged from 0.1% to 2.57%: and atypical squamous cells of undetermined significance/squamous intraepithelial lesions ranged from 0.31 to 1.02. Conclusion: In 2012 and 2013, the high-grade squamous intraepithelial lesion/satisfactory and the positivity index indicators were below the recommended parameters, and in the remaining years, these indicators were within the parameters recommended. Consequently, a greater number of truly cancer precursor lesions were identified, demonstrating the importance of internal quality control in the prevention of cervical cancer.","PeriodicalId":35397,"journal":{"name":"Jornal Brasileiro de Patologia e Medicina Laboratorial","volume":"56 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71116875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.5935/1676-2444.20200052
Carlos Eduardo S. Ferreira, C. A. Moreira, L. S. Vasconcellos
{"title":"Template for the laboratory’s report of 25-hydroxyvitamin D: recommendations form the Brazilian Society of Clinical Pathology/Laboratory Medicine (SBPC/ML) and the Brazilian Society of Endocrinology and Metabolism (SBEM)","authors":"Carlos Eduardo S. Ferreira, C. A. Moreira, L. S. Vasconcellos","doi":"10.5935/1676-2444.20200052","DOIUrl":"https://doi.org/10.5935/1676-2444.20200052","url":null,"abstract":"","PeriodicalId":35397,"journal":{"name":"Jornal Brasileiro de Patologia e Medicina Laboratorial","volume":"175 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71117231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.1016/j.oooo.2019.06.284
C. Campos, H. Santos, E. Morais, A. N. Dantas, Rani Iani Costa Gonçado, H. Galvão, R. Freitas
{"title":"Mucoepidermoid carcinoma of the retromolar region: case report","authors":"C. Campos, H. Santos, E. Morais, A. N. Dantas, Rani Iani Costa Gonçado, H. Galvão, R. Freitas","doi":"10.1016/j.oooo.2019.06.284","DOIUrl":"https://doi.org/10.1016/j.oooo.2019.06.284","url":null,"abstract":"","PeriodicalId":35397,"journal":{"name":"Jornal Brasileiro de Patologia e Medicina Laboratorial","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.oooo.2019.06.284","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42235870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.5935/1676-2444.20200003
C. Cordova, Ariane S. Portal, Maurício Mendes de Cordova
{"title":"Fórmulas de Martin, Friedewald e Cordova comparadas com a dosagem direta do LDL-C no sul do Brasil","authors":"C. Cordova, Ariane S. Portal, Maurício Mendes de Cordova","doi":"10.5935/1676-2444.20200003","DOIUrl":"https://doi.org/10.5935/1676-2444.20200003","url":null,"abstract":"","PeriodicalId":35397,"journal":{"name":"Jornal Brasileiro de Patologia e Medicina Laboratorial","volume":"56 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71115871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.5935/1676-2444.20200006
Flora Ávila Adorno, Daniele Cristina F. Lousada, Karina Munhoz de Paula Alves Coelho, Paulo Henrique Praça de França
{"title":"A utilidade da captura híbrida para o HPV de alto risco em pacientes com atipia de células escamosas na colpocitologia","authors":"Flora Ávila Adorno, Daniele Cristina F. Lousada, Karina Munhoz de Paula Alves Coelho, Paulo Henrique Praça de França","doi":"10.5935/1676-2444.20200006","DOIUrl":"https://doi.org/10.5935/1676-2444.20200006","url":null,"abstract":"","PeriodicalId":35397,"journal":{"name":"Jornal Brasileiro de Patologia e Medicina Laboratorial","volume":"56 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71116284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.5935/1676-2444.20200018
Thiago Acrux, D. Athanazio, Débora Gaudêncio, C. Rocha
Objective: This study evaluated the histopathological features of ductal carcinoma in situ (DCIS), including cytological grade, architectural pattern and immunohistochemistry (IHC) in pure DCIS and DCIS associated with invasive carcinoma of no special type (ICNST). Methods: We evaluated a series of 232 cases of pure DCIS and DCIS associated with ICNST from a total of 399 breast carcinomas from a population consisting by women diagnosed with breast cancer and submitted to breast surgery from 2011 to 2015. Results: DCIS presented a mixed architectural pattern in most cases (56%); the solid subtype was the most common morphology (30%). High-grade DCIS was identified in 84/221 cases (38%), and comedonecrosis was present in 106/221 cases (48%). High-grade was more common in the solid subtype (61/155 cases, 39%, p < 0.001). Tumor size was greater in the presence of comedonecrosis than in the absence (mean 27 vs 20 mm, p = 0.009). Estrogen receptor (ER) was positive in 81% of cases with a cribriform pattern (p = 0.013). Greater locoregional recurrence was found in the comedonecrosis (15%) and micropapillary (19%) subtypes in DCIS associated with ICNST. Conclusion: We observed a greater relationship of ER with the low nuclear grade, while Ki-67 was related to the high-grade. DCIS presented a higher nuclear grade compared to ICNST. The less common pure pattern was the micropapillary, and the most common, the solid. Comedonecrosis was more frequent in the solid pattern. Our results showed that high-grade was more common in the solid and comedo subtype, and low-grade was more frequent in the cribriform.
目的:探讨导管原位癌(ductal carcinoma in situ, DCIS)的组织学特征，包括单纯DCIS和DCIS合并浸润性无特殊类型癌(invasive carcinoma of no special type, ICNST)的细胞学分级、建筑形态和免疫组化(immunohistochemistry, IHC)。方法:我们评估了232例单纯DCIS和DCIS与ICNST相关的病例，这些病例来自于2011年至2015年确诊为乳腺癌并接受乳房手术的女性群体，共399例乳腺癌。结果:DCIS多数病例(56%)呈现混合型结构模式;固体亚型是最常见的形态(30%)。高度DCIS在84/221例(38%)中被发现，秃发坏死在106/221例(48%)中出现。高级别肿瘤在实性亚型中更为常见(61/155例，39%，p < 0.001)。有秃发坏死时肿瘤大小大于无秃发坏死时(平均27mm vs 20mm, p = 0.009)。81%筛状型患者雌激素受体(ER)阳性(p = 0.013)。在与ICNST相关的DCIS中，头颈部坏死(15%)和微乳头状(19%)亚型的局部复发率较高。结论:ER与低核分级关系密切，Ki-67与高核分级关系密切。与ICNST相比，DCIS表现出更高的核分级。不太常见的纯型是微乳头状，最常见的是实型。实型结节坏死多见。我们的结果显示，高级别在实体型和粉刺型中更为常见，低级别在筛网型中更为常见。
{"title":"Ductal carcinoma in situ of the breast: correlation of architectural, cytological,\u0000 IHC findings and recurrence analysis","authors":"Thiago Acrux, D. Athanazio, Débora Gaudêncio, C. Rocha","doi":"10.5935/1676-2444.20200018","DOIUrl":"https://doi.org/10.5935/1676-2444.20200018","url":null,"abstract":"Objective: This study evaluated the histopathological features of ductal carcinoma in situ (DCIS), including cytological grade, architectural pattern and immunohistochemistry (IHC) in pure DCIS and DCIS associated with invasive carcinoma of no special type (ICNST). Methods: We evaluated a series of 232 cases of pure DCIS and DCIS associated with ICNST from a total of 399 breast carcinomas from a population consisting by women diagnosed with breast cancer and submitted to breast surgery from 2011 to 2015. Results: DCIS presented a mixed architectural pattern in most cases (56%); the solid subtype was the most common morphology (30%). High-grade DCIS was identified in 84/221 cases (38%), and comedonecrosis was present in 106/221 cases (48%). High-grade was more common in the solid subtype (61/155 cases, 39%, p < 0.001). Tumor size was greater in the presence of comedonecrosis than in the absence (mean 27 vs 20 mm, p = 0.009). Estrogen receptor (ER) was positive in 81% of cases with a cribriform pattern (p = 0.013). Greater locoregional recurrence was found in the comedonecrosis (15%) and micropapillary (19%) subtypes in DCIS associated with ICNST. Conclusion: We observed a greater relationship of ER with the low nuclear grade, while Ki-67 was related to the high-grade. DCIS presented a higher nuclear grade compared to ICNST. The less common pure pattern was the micropapillary, and the most common, the solid. Comedonecrosis was more frequent in the solid pattern. Our results showed that high-grade was more common in the solid and comedo subtype, and low-grade was more frequent in the cribriform.","PeriodicalId":35397,"journal":{"name":"Jornal Brasileiro de Patologia e Medicina Laboratorial","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71116378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.5935/1676-2444.20200034
Raquel Ferreira, Leonardo C Dentz, E. Assis, R. S. Laboissière
Noncutaneous melanoma is a rare clinical entity, and their primary or secondary nature is often difficult to establish. Few cases of primary gastric melanoma have been described in the literature. We report a case of a 55-year-old male patient with dyspepsia complaints. Esophagogastroduodenoscopy revealed a polypoid mass with blackened areas at the greater curvature of the gastric body, which was histologically compatible with melanoma; positive immunohistochemistry for S100, melan-A, and vimentin. The extensive dermatological exam did not identify a primary lesion.
{"title":"Primary gastric melanoma: a case report of a rare malignancy","authors":"Raquel Ferreira, Leonardo C Dentz, E. Assis, R. S. Laboissière","doi":"10.5935/1676-2444.20200034","DOIUrl":"https://doi.org/10.5935/1676-2444.20200034","url":null,"abstract":"Noncutaneous melanoma is a rare clinical entity, and their primary or secondary nature is often difficult to establish. Few cases of primary gastric melanoma have been described in the literature. We report a case of a 55-year-old male patient with dyspepsia complaints. Esophagogastroduodenoscopy revealed a polypoid mass with blackened areas at the greater curvature of the gastric body, which was histologically compatible with melanoma; positive immunohistochemistry for S100, melan-A, and vimentin. The extensive dermatological exam did not identify a primary lesion.","PeriodicalId":35397,"journal":{"name":"Jornal Brasileiro de Patologia e Medicina Laboratorial","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71116865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.5935/1676-2444.20200044
M. Almeida, Michele R. Feroldi, L. Vianna, Eloisa B. Parreira
{"title":"Basal cell carcinoma of the areola: a rare case report","authors":"M. Almeida, Michele R. Feroldi, L. Vianna, Eloisa B. Parreira","doi":"10.5935/1676-2444.20200044","DOIUrl":"https://doi.org/10.5935/1676-2444.20200044","url":null,"abstract":"","PeriodicalId":35397,"journal":{"name":"Jornal Brasileiro de Patologia e Medicina Laboratorial","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71116944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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