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Jornal Brasileiro de Patologia e Medicina Laboratorial最新文献

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Evaluation of the influence of pre-analytical factors on total testosterone levels in healthy young men 评价分析前因素对健康青年男性总睾酮水平的影响
Q4 Medicine
Jornal Brasileiro de Patologia e Medicina Laboratorial
Pub Date : 2021-01-01 DOI: 10.5935/1676-2444.20210016
I. L. Lima, I. Neves, Izabela Resende E. Costa, Matheus C. Caplum, Pedro Oliveira, R. Mello
{"title":"Evaluation of the influence of pre-analytical factors on total testosterone levels in healthy young men","authors":"I. L. Lima, I. Neves, Izabela Resende E. Costa, Matheus C. Caplum, Pedro Oliveira, R. Mello","doi":"10.5935/1676-2444.20210016","DOIUrl":"https://doi.org/10.5935/1676-2444.20210016","url":null,"abstract":"","PeriodicalId":35397,"journal":{"name":"Jornal Brasileiro de Patologia e Medicina Laboratorial","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71118253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multicentric osteoblastoma-like: report of a rare case in the craniofacial region 多中心骨母细胞瘤样:颅面区一例罕见病例报告
Q4 Medicine
Jornal Brasileiro de Patologia e Medicina Laboratorial
Pub Date : 2021-01-01 DOI: 10.5935/1676-2444.20210033
H.G.M. Jurema, E. Bicca, Raul Jablonski Júnior
{"title":"Multicentric osteoblastoma-like: report of a rare case in the craniofacial region","authors":"H.G.M. Jurema, E. Bicca, Raul Jablonski Júnior","doi":"10.5935/1676-2444.20210033","DOIUrl":"https://doi.org/10.5935/1676-2444.20210033","url":null,"abstract":"","PeriodicalId":35397,"journal":{"name":"Jornal Brasileiro de Patologia e Medicina Laboratorial","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71118425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Performance evaluation of a Sars-CoV-2 rapid test and two automated immunoassays Sars-CoV-2快速检测和两种自动免疫分析的性能评估
Q4 Medicine
Jornal Brasileiro de Patologia e Medicina Laboratorial
Pub Date : 2021-01-01 DOI: 10.5935/1676-2444.20210040
M. Castejon, Rosemeire Yamashiro, E. L. Oliveira, E. Silveira, M. Hong, Carmem Aparecida F. Oliveira, V. O. Silva, C. Ahagon, A. K. Lima, J. Lindoso, L. Brigido
Due to urgency and demand of a response to the Covid-19 pandemic, numerous Sars-CoV-2 immunoassays have been rapidly developed. Objective: This study aimed at assessing the performance of rapid Sars-CoV-2 antibody test in comparison to high-throughput serological assays. Methods: A total of 86 serum samples were evaluated in the three assays: a lateral flow immunoassay - Wondfo Sars-CoV-2 Antibody Test (WRT) - and two chemiluminescence immunoassays: Elecsys Anti-Sars-CoV-2 (ECLIA), and Sars-CoV-2 IgG (CMIA-IgG). Results: The estimated diagnostic sensitivities of serological tests in the evaluation of serum samples from the epidemiological survey were: WRT 59% [95% confidence interval (CI) 43.4%-72.9%], ECLIA 66.7% (51%-79.4%), and CMIA-IgG 61.5% (47.1%-73%). Meanwhile, the estimated diagnostic specificity was for WRT 78.7% (95% CI 65.1%-88%), ECLIA 72.3% (58.2%-83.1%), and CMIA-IgG 76.6% (74%-95.5%). The sensitivity and specificity values were lower than manufacturers' claimed. Although 16.2% (14/86) of serological results were discordant among the three Sars-CoV-2 serological assays, the degree of agreement by the kappa index was adequate: WRT/CMIA-IgG [0.757 (95% CI 0.615-0.899)], WRT/ECLIA [0.715 (0.565-0.864)], and ECLIA/CMIA-IgG [0.858 (0.748-0.968)]. Conclusion: The serological testing may be a useful diagnostic tool, which reinforces its careful evaluation, and, as well as the correct time to use it. © 2021 Sociedade Brasileira de Pneumologia e Tisiologia. All rights reserved.
由于应对Covid-19大流行的紧迫性和需求，迅速开发了许多Sars-CoV-2免疫测定方法。目的:比较快速Sars-CoV-2抗体检测与高通量血清学检测的性能。方法:采用横向流动免疫分析法- Wondfo Sars-CoV-2抗体试验(WRT)和两种化学发光免疫分析法:Elecsys Anti-Sars-CoV-2 (ECLIA)和Sars-CoV-2 IgG (cia -IgG)对86份血清样本进行评估。结果:在流行病学调查血清样本评估中，血清学检测的诊断敏感性估计为:WRT 59%[95%可信区间(CI) 43.4% ~ 72.9%]， ECLIA 66.7% (51% ~ 79.4%)， CMIA-IgG 61.5%(47.1% ~ 73%)。同时，估计诊断特异性WRT为78.7% (95% CI 65.1%-88%)， ECLIA为72.3% (58.2%-83.1%)，CMIA-IgG为76.6%(74%-95.5%)。灵敏度和特异性值低于制造商声称的。虽然三种Sars-CoV-2血清学检测结果有16.2%(14/86)不一致，但kappa指数的一致程度是足够的:WRT/CMIA-IgG [0.757 (95% CI 0.615-0.899)]， WRT/ECLIA [0.715 (0.565-0.864)]， ECLIA/CMIA-IgG[0.858(0.748-0.968)]。结论:血清学检测可作为一种有用的诊断工具，但应加强对血清学检测的谨慎评估，并在正确的时间使用血清学检测。©2021巴西肺病学会。版权所有。
{"title":"Performance evaluation of a Sars-CoV-2 rapid test and two automated immunoassays","authors":"M. Castejon, Rosemeire Yamashiro, E. L. Oliveira, E. Silveira, M. Hong, Carmem Aparecida F. Oliveira, V. O. Silva, C. Ahagon, A. K. Lima, J. Lindoso, L. Brigido","doi":"10.5935/1676-2444.20210040","DOIUrl":"https://doi.org/10.5935/1676-2444.20210040","url":null,"abstract":"Due to urgency and demand of a response to the Covid-19 pandemic, numerous Sars-CoV-2 immunoassays have been rapidly developed. Objective: This study aimed at assessing the performance of rapid Sars-CoV-2 antibody test in comparison to high-throughput serological assays. Methods: A total of 86 serum samples were evaluated in the three assays: a lateral flow immunoassay - Wondfo Sars-CoV-2 Antibody Test (WRT) - and two chemiluminescence immunoassays: Elecsys Anti-Sars-CoV-2 (ECLIA), and Sars-CoV-2 IgG (CMIA-IgG). Results: The estimated diagnostic sensitivities of serological tests in the evaluation of serum samples from the epidemiological survey were: WRT 59% [95% confidence interval (CI) 43.4%-72.9%], ECLIA 66.7% (51%-79.4%), and CMIA-IgG 61.5% (47.1%-73%). Meanwhile, the estimated diagnostic specificity was for WRT 78.7% (95% CI 65.1%-88%), ECLIA 72.3% (58.2%-83.1%), and CMIA-IgG 76.6% (74%-95.5%). The sensitivity and specificity values were lower than manufacturers' claimed. Although 16.2% (14/86) of serological results were discordant among the three Sars-CoV-2 serological assays, the degree of agreement by the kappa index was adequate: WRT/CMIA-IgG [0.757 (95% CI 0.615-0.899)], WRT/ECLIA [0.715 (0.565-0.864)], and ECLIA/CMIA-IgG [0.858 (0.748-0.968)]. Conclusion: The serological testing may be a useful diagnostic tool, which reinforces its careful evaluation, and, as well as the correct time to use it. © 2021 Sociedade Brasileira de Pneumologia e Tisiologia. All rights reserved.","PeriodicalId":35397,"journal":{"name":"Jornal Brasileiro de Patologia e Medicina Laboratorial","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71118668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CRISPR-Cas9 system: an alternative therapy for lung cancer CRISPR-Cas9系统:肺癌的替代疗法
Q4 Medicine
Jornal Brasileiro de Patologia e Medicina Laboratorial
Pub Date : 2021-01-01 DOI: 10.5935/1676-2444.20210051
A. S. R. Almeida, C. B. Souza
{"title":"CRISPR-Cas9 system: an alternative therapy for lung cancer","authors":"A. S. R. Almeida, C. B. Souza","doi":"10.5935/1676-2444.20210051","DOIUrl":"https://doi.org/10.5935/1676-2444.20210051","url":null,"abstract":"","PeriodicalId":35397,"journal":{"name":"Jornal Brasileiro de Patologia e Medicina Laboratorial","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71118721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of galectin-3 levels in patients with type 2 diabetes mellitus and chronic kidney disease 2型糖尿病合并慢性肾病患者半乳糖凝集素-3水平的评价
Q4 Medicine
Jornal Brasileiro de Patologia e Medicina Laboratorial
Pub Date : 2021-01-01 DOI: 10.5935/1676-2444.20210010
Isabella D. P. Souza, K. F. Rodrigues, N. T. Pietrani, A. Bosco, K. Gomes, M. Alves
{"title":"Evaluation of galectin-3 levels in patients with type 2 diabetes mellitus and chronic kidney disease","authors":"Isabella D. P. Souza, K. F. Rodrigues, N. T. Pietrani, A. Bosco, K. Gomes, M. Alves","doi":"10.5935/1676-2444.20210010","DOIUrl":"https://doi.org/10.5935/1676-2444.20210010","url":null,"abstract":"","PeriodicalId":35397,"journal":{"name":"Jornal Brasileiro de Patologia e Medicina Laboratorial","volume":"57 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71117833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Analysis of TIMP-1 expression in leukoplakia and oral squamous cell carcinoma TIMP-1在口腔白斑和口腔鳞状细胞癌中的表达分析
Q4 Medicine
Jornal Brasileiro de Patologia e Medicina Laboratorial
Pub Date : 2021-01-01 DOI: 10.5935/1676-2444.20210025
S. Nascimento, L. N. G. Souza, L. Barros
{"title":"Analysis of TIMP-1 expression in leukoplakia and oral squamous cell carcinoma","authors":"S. Nascimento, L. N. G. Souza, L. Barros","doi":"10.5935/1676-2444.20210025","DOIUrl":"https://doi.org/10.5935/1676-2444.20210025","url":null,"abstract":"","PeriodicalId":35397,"journal":{"name":"Jornal Brasileiro de Patologia e Medicina Laboratorial","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71118100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Soft tissue myoepithelial carcinoma: is it a low-grade cancer? 软组织肌上皮癌:是一种低级别癌症吗?
Q4 Medicine
Jornal Brasileiro de Patologia e Medicina Laboratorial
Pub Date : 2021-01-01 DOI: 10.5935/1676-2444.20210018
L. A. A. França, B. V. D. Deus, Plínio Medeiros Filho
{"title":"Soft tissue myoepithelial carcinoma: is it a low-grade cancer?","authors":"L. A. A. França, B. V. D. Deus, Plínio Medeiros Filho","doi":"10.5935/1676-2444.20210018","DOIUrl":"https://doi.org/10.5935/1676-2444.20210018","url":null,"abstract":"","PeriodicalId":35397,"journal":{"name":"Jornal Brasileiro de Patologia e Medicina Laboratorial","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71118307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The importance of flow cytometry in the diagnosis and monitoring of paroxysmal nocturnal hemoglobinuria 流式细胞术在阵发性夜间血红蛋白尿诊断和监测中的重要性
Q4 Medicine
Jornal Brasileiro de Patologia e Medicina Laboratorial
Pub Date : 2021-01-01 DOI: 10.5935/1676-2444.20210019
L. R. Ehlert, Camila L. Silva, Allyne Cristina Grando
{"title":"The importance of flow cytometry in the diagnosis and monitoring of paroxysmal nocturnal hemoglobinuria","authors":"L. R. Ehlert, Camila L. Silva, Allyne Cristina Grando","doi":"10.5935/1676-2444.20210019","DOIUrl":"https://doi.org/10.5935/1676-2444.20210019","url":null,"abstract":"","PeriodicalId":35397,"journal":{"name":"Jornal Brasileiro de Patologia e Medicina Laboratorial","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71118354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of pre-analytical errors on costs of clinical analysis laboratory 分析前错误对临床分析实验室成本的影响
Q4 Medicine
Jornal Brasileiro de Patologia e Medicina Laboratorial
Pub Date : 2021-01-01 DOI: 10.5935/1676-2444.20210023
P. Santos, Camila Anselmo da Silva, M. C. Gall, Allyne Cristina Grando
{"title":"Impact of pre-analytical errors on costs of clinical analysis laboratory","authors":"P. Santos, Camila Anselmo da Silva, M. C. Gall, Allyne Cristina Grando","doi":"10.5935/1676-2444.20210023","DOIUrl":"https://doi.org/10.5935/1676-2444.20210023","url":null,"abstract":"","PeriodicalId":35397,"journal":{"name":"Jornal Brasileiro de Patologia e Medicina Laboratorial","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71118408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cutaneous horn occurring on the oral tissues: report of a case and review of literature 皮肤角发生在口腔组织:一个病例报告和文献复习
Q4 Medicine
Jornal Brasileiro de Patologia e Medicina Laboratorial
Pub Date : 2021-01-01 DOI: 10.5935/1676-2444.20210032
Lucas C. Fallieri, Gabriela Ferreira, B. C. Barbosa, M. S. Araújo, P. Henrique, J. Servato
{"title":"Cutaneous horn occurring on the oral tissues: report of a case and review of literature","authors":"Lucas C. Fallieri, Gabriela Ferreira, B. C. Barbosa, M. S. Araújo, P. Henrique, J. Servato","doi":"10.5935/1676-2444.20210032","DOIUrl":"https://doi.org/10.5935/1676-2444.20210032","url":null,"abstract":"","PeriodicalId":35397,"journal":{"name":"Jornal Brasileiro de Patologia e Medicina Laboratorial","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71118551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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