Pub Date : 2020-07-15DOI: 10.14188/J.1671-8852.2020.0126
Zilong Lu, Ruyuan He, Wenyang Jiang, Tao Fan, Q. Geng
{"title":"Clinical characteristics and immune function analysis of COVID-19","authors":"Zilong Lu, Ruyuan He, Wenyang Jiang, Tao Fan, Q. Geng","doi":"10.14188/J.1671-8852.2020.0126","DOIUrl":"https://doi.org/10.14188/J.1671-8852.2020.0126","url":null,"abstract":"","PeriodicalId":35402,"journal":{"name":"Medical Journal of Wuhan University","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49203857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-15DOI: 10.14188/J.1671-8852.2020.0087
Jia Cao, Jun Zhou, Xingnan Liao, Gonghao Ling, Xun Ding, Qing-yun Long
The CT findings of 36 elderly patients with novel coronavirus disease 2019 (COVID-19)were analyzed to provide imaging diagnostic basis for clin diagnosis Methods: The clin date and chest CT images of 36 elderly patients with pos new coronavirus nucleic acid admitted to Zhongnan Hospital of Wuhan University were retrospectively analyzed Results:: Elderly COVID-19 patients had more underlying diseases, with more complicated clin symptoms than young patients, including fever (77 8%), cough (55 6%), and dyspnea (52 8%);CT signs are characterized by diversity and multi-focus, mainly showing the coexistence of ground-glass shadow and consolidation shadow (72 2%), mostly located in the outer lung field of bilateral lung (69 4%), and the air bronchus sign (58 3%) in the lesions COVID-19 in the elderly progresses relatively fast, and severe patients were more common, and 55 6% patients were male Conclusion:: CT images of elderly COVID-19 patients have certain characteristics Chest thin-section CT is helpful for early diagnosis and provides an effective supplement to nucleic acid detection for SARS-CoV-2
{"title":"Clinical characteristics and CT signs of coronavirus disease 2019 (COVID-19) in the elderly","authors":"Jia Cao, Jun Zhou, Xingnan Liao, Gonghao Ling, Xun Ding, Qing-yun Long","doi":"10.14188/J.1671-8852.2020.0087","DOIUrl":"https://doi.org/10.14188/J.1671-8852.2020.0087","url":null,"abstract":"The CT findings of 36 elderly patients with novel coronavirus disease 2019 (COVID-19)were analyzed to provide imaging diagnostic basis for clin diagnosis Methods: The clin date and chest CT images of 36 elderly patients with pos new coronavirus nucleic acid admitted to Zhongnan Hospital of Wuhan University were retrospectively analyzed Results:: Elderly COVID-19 patients had more underlying diseases, with more complicated clin symptoms than young patients, including fever (77 8%), cough (55 6%), and dyspnea (52 8%);CT signs are characterized by diversity and multi-focus, mainly showing the coexistence of ground-glass shadow and consolidation shadow (72 2%), mostly located in the outer lung field of bilateral lung (69 4%), and the air bronchus sign (58 3%) in the lesions COVID-19 in the elderly progresses relatively fast, and severe patients were more common, and 55 6% patients were male Conclusion:: CT images of elderly COVID-19 patients have certain characteristics Chest thin-section CT is helpful for early diagnosis and provides an effective supplement to nucleic acid detection for SARS-CoV-2","PeriodicalId":35402,"journal":{"name":"Medical Journal of Wuhan University","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47887595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-15DOI: 10.14188/J.1671-8852.2020.0136
Qian Chen, M. Pei, Yao Wang, Z. Gong
A review The breakout of coronavirus disease 2019 (COVID-19) has great impact on human health The main mechanism of glucocorticoids in the treatment of viral pneumonia is to suppress inflammatory responses However, the therapeutic effect of glucocorticoids in COVID-19 patients is not clear In addition, glucocorticoids had certain adverse effect in the treatment of other viral pneumonia There is still much controversy among clin experts about the use of glucocorticoids in COVID-19 This article reviews the mechanism, time, dose, treatment, advantages and disadvantages of glucocorticoids in the treatment of COVID-19
{"title":"Glucocorticoid application in the treatment of coronavirus disease 2019(COVID-19): the pros and cons","authors":"Qian Chen, M. Pei, Yao Wang, Z. Gong","doi":"10.14188/J.1671-8852.2020.0136","DOIUrl":"https://doi.org/10.14188/J.1671-8852.2020.0136","url":null,"abstract":"A review The breakout of coronavirus disease 2019 (COVID-19) has great impact on human health The main mechanism of glucocorticoids in the treatment of viral pneumonia is to suppress inflammatory responses However, the therapeutic effect of glucocorticoids in COVID-19 patients is not clear In addition, glucocorticoids had certain adverse effect in the treatment of other viral pneumonia There is still much controversy among clin experts about the use of glucocorticoids in COVID-19 This article reviews the mechanism, time, dose, treatment, advantages and disadvantages of glucocorticoids in the treatment of COVID-19","PeriodicalId":35402,"journal":{"name":"Medical Journal of Wuhan University","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41896501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-15DOI: 10.14188/J.1671-8852.2020.6018
T. Suo, Hui Fan, Guo-zhong Chen
A review As research has progressed, viral pathogens are increasingly recognized as a cause of pneumonia More than 20 viruses have been linked to community acquired pneumonia (CAP) Apart from the US Food and Drug Administration approved medications for treatment of influenza pneumonia, the treatment of noninfluenza respiratory viruses is limited In order to provide more theor basis for the clin treatment of viral pneumonia, this paper summarizes the related research progress of viral pneumonia treatment
{"title":"Advances in the treatment of viral pneumonia","authors":"T. Suo, Hui Fan, Guo-zhong Chen","doi":"10.14188/J.1671-8852.2020.6018","DOIUrl":"https://doi.org/10.14188/J.1671-8852.2020.6018","url":null,"abstract":"A review As research has progressed, viral pathogens are increasingly recognized as a cause of pneumonia More than 20 viruses have been linked to community acquired pneumonia (CAP) Apart from the US Food and Drug Administration approved medications for treatment of influenza pneumonia, the treatment of noninfluenza respiratory viruses is limited In order to provide more theor basis for the clin treatment of viral pneumonia, this paper summarizes the related research progress of viral pneumonia treatment","PeriodicalId":35402,"journal":{"name":"Medical Journal of Wuhan University","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48553467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-15DOI: 10.14188/J.1671-8852.2020.0095
W. Zou, Bin Song, Xiaowei Wu
The present study relates to report the diagnosis and treatment process of a case of coronavirus disease 2019(COVID-19) complicated with acute pulmonary embolism
报道1例新型冠状病毒病2019(COVID-19)合并急性肺栓塞的诊治过程
{"title":"Severe COVID-19 complicated with pulmonary embolism: a case report and literature review","authors":"W. Zou, Bin Song, Xiaowei Wu","doi":"10.14188/J.1671-8852.2020.0095","DOIUrl":"https://doi.org/10.14188/J.1671-8852.2020.0095","url":null,"abstract":"The present study relates to report the diagnosis and treatment process of a case of coronavirus disease 2019(COVID-19) complicated with acute pulmonary embolism","PeriodicalId":35402,"journal":{"name":"Medical Journal of Wuhan University","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45386055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.14188/J.1671-8852.2015.04.015
LU Yula
Objective:To evaluate the clinical efficacy and perioperative safety of cytoreductive surgery(CRS)in conjunction with hyperthermic intraperitonealchemotherapy(HIPEC)for treating patients with stage Ⅲc ovarian cancer.Methods:A total of 50 stage Ⅲc ovarian cancer patients were divided into the CRS(n=30),and the CRS + HIPEC group(n=24).The primary end point was overall survival(OS)and the second end points were serious adverse events(SAE).Results:The median follow-up was 44.1 months(6to 168 months)in CRS Group and 42.6months(10.5to 110.9 months)in CRS + HIPEC Group.The median OS was 27.1 months(95%CI,21.8-35.3 months)in CRS Group and 32.6 months(95%CI,24.8-40.6 months)in CRS + HIPEC Group(P0.05).Within 30 days after the surgery,SAE occurred in 3of the 30 patients in CRS Group,and in 5of the 24 patients in CRS+HIPEC Group(P=0.466).Multivariate analysis revealed that CRS + HIPEC,operation satisfaction,and chemotherapy over sixcycles were the independent factors for OS improvement.Conclusion:The CRS+HIPEC method improves the OS of stageⅢ c ovarian cancer patients,suggesting an acceptable safety.
{"title":"Cytoreductive Surgery Plus Hyperthermic Intraperitoneal Chemotherapy Improves Survivalin Patients with StageIIIc Ovarian Cancer","authors":"LU Yula","doi":"10.14188/J.1671-8852.2015.04.015","DOIUrl":"https://doi.org/10.14188/J.1671-8852.2015.04.015","url":null,"abstract":"Objective:To evaluate the clinical efficacy and perioperative safety of cytoreductive surgery(CRS)in conjunction with hyperthermic intraperitonealchemotherapy(HIPEC)for treating patients with stage Ⅲc ovarian cancer.Methods:A total of 50 stage Ⅲc ovarian cancer patients were divided into the CRS(n=30),and the CRS + HIPEC group(n=24).The primary end point was overall survival(OS)and the second end points were serious adverse events(SAE).Results:The median follow-up was 44.1 months(6to 168 months)in CRS Group and 42.6months(10.5to 110.9 months)in CRS + HIPEC Group.The median OS was 27.1 months(95%CI,21.8-35.3 months)in CRS Group and 32.6 months(95%CI,24.8-40.6 months)in CRS + HIPEC Group(P0.05).Within 30 days after the surgery,SAE occurred in 3of the 30 patients in CRS Group,and in 5of the 24 patients in CRS+HIPEC Group(P=0.466).Multivariate analysis revealed that CRS + HIPEC,operation satisfaction,and chemotherapy over sixcycles were the independent factors for OS improvement.Conclusion:The CRS+HIPEC method improves the OS of stageⅢ c ovarian cancer patients,suggesting an acceptable safety.","PeriodicalId":35402,"journal":{"name":"Medical Journal of Wuhan University","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66656623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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