T. Wijayanti, Yati Afiyanti, Hayuni Rahmah, Ariesta Milanti
Accepted 2018-06-26 INTRODUCTION Fear of cancer recurrence (FCR) is among the top concerns of cancer survivors regardless of the type of cancer (1). For the gynecological cancer (GC) survivors, recurrence is indeed a major issue due to its high recurrence rates coupled with its tendency of being asymptomatic and diagnosed at advanced stage (2). Many women with GC are aware of this fact and experience a constant fear of having cancer over time (3,4). Despite some conflicting findings of the FCR prevalence and its relations with the cancer prognosis and survival, a recent review suggests that FCR is a ubiquitous and persistent among the cancer survivors and is strongly associated with lower quality of life (QOL) (5). FCR is also poorly addressed in the survivorship care planning and care even though its incidence has been much evident (6). Many different factors can influence FCR, including sociodemographic, clinical, and psychological factors (5,7). Prior studies indicated that cultural background may account for variance of FCR (8,9). Researchers posit that different cultural groups may have distinct coping style, communication style, and social support which contribute to FCR variability (5,8). The belief such as fatalism, i.e. pessimistic view about the probability of surviving a disease, remains evident in many cultures, as shown, for example, in studies done in Turkey (10) and Portugal (11). Such belief may shape the way women perceive their experience of living with GC. In addition, a study in Iran showed how Iranian cancer patients frequently had high level of FCR mainly due to their concern about their family and children, not because of their own self-concern (12). In line with this, another study suggested what women fear the most about having their cancer back – it was the implication of their inability to perform social roles, especially their motherhood or womanhood roles, which were then associated with the poor QOL (13). These studies are among the many evidences regarding the interplays of the sociocultural dimension of FCR. Since FCR may have prominent sociocultural attributes, it deemed necessary to examine FCR in Indonesia. Indonesia, as a middle-income country in South-east Asia has a high incidence of GC, with cervical cancer being the most prevalent (14,15). The number of GC survivors is continuously increasing due to the large population and high incidence, albeit low survival (16). Cancer survivorship issues, including FCR, are mostly unexplored in Indonesia (17). Hence, there is still insufficient basis for understanding and addressing this problem. On a different note, Indonesian people hold a strong collectivist culture (18). Studies found that in Indonesia GC survivors received social, emotional, spiritual, and even financial support not only from their family or close relatives but also from their neighbors and colleagues (19,20). Whether this common social feature may influence the FCR among the GC survivors in Indone
{"title":"Fear of cancer recurrence and social support among Indonesian gynecological cancer survivors","authors":"T. Wijayanti, Yati Afiyanti, Hayuni Rahmah, Ariesta Milanti","doi":"10.2298/AOO180201004W","DOIUrl":"https://doi.org/10.2298/AOO180201004W","url":null,"abstract":"Accepted 2018-06-26 INTRODUCTION Fear of cancer recurrence (FCR) is among the top concerns of cancer survivors regardless of the type of cancer (1). For the gynecological cancer (GC) survivors, recurrence is indeed a major issue due to its high recurrence rates coupled with its tendency of being asymptomatic and diagnosed at advanced stage (2). Many women with GC are aware of this fact and experience a constant fear of having cancer over time (3,4). Despite some conflicting findings of the FCR prevalence and its relations with the cancer prognosis and survival, a recent review suggests that FCR is a ubiquitous and persistent among the cancer survivors and is strongly associated with lower quality of life (QOL) (5). FCR is also poorly addressed in the survivorship care planning and care even though its incidence has been much evident (6). Many different factors can influence FCR, including sociodemographic, clinical, and psychological factors (5,7). Prior studies indicated that cultural background may account for variance of FCR (8,9). Researchers posit that different cultural groups may have distinct coping style, communication style, and social support which contribute to FCR variability (5,8). The belief such as fatalism, i.e. pessimistic view about the probability of surviving a disease, remains evident in many cultures, as shown, for example, in studies done in Turkey (10) and Portugal (11). Such belief may shape the way women perceive their experience of living with GC. In addition, a study in Iran showed how Iranian cancer patients frequently had high level of FCR mainly due to their concern about their family and children, not because of their own self-concern (12). In line with this, another study suggested what women fear the most about having their cancer back – it was the implication of their inability to perform social roles, especially their motherhood or womanhood roles, which were then associated with the poor QOL (13). These studies are among the many evidences regarding the interplays of the sociocultural dimension of FCR. Since FCR may have prominent sociocultural attributes, it deemed necessary to examine FCR in Indonesia. Indonesia, as a middle-income country in South-east Asia has a high incidence of GC, with cervical cancer being the most prevalent (14,15). The number of GC survivors is continuously increasing due to the large population and high incidence, albeit low survival (16). Cancer survivorship issues, including FCR, are mostly unexplored in Indonesia (17). Hence, there is still insufficient basis for understanding and addressing this problem. On a different note, Indonesian people hold a strong collectivist culture (18). Studies found that in Indonesia GC survivors received social, emotional, spiritual, and even financial support not only from their family or close relatives but also from their neighbors and colleagues (19,20). Whether this common social feature may influence the FCR among the GC survivors in Indone","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":"24 1","pages":"12-19"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68402766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sovan Dhar Sarang, R. Sahoo, Z. Hossain, Majumdar Das Saroj, Dillip Kumar
www.onk.ns.ac.rs/Archive • Volume 24 • Issue 1 • 2018 INTRODUCTION Occipital Neuralgia (ON) is characterised by sharp shooting pain arising in the sensory distribution of occipital nerves. Owing to be an uncommon diagnosis and at the same time due to overlap in criteria with more common neuralgias, its incidence and prevalence is rarely reported (1). A study in the Dutch general population reported a relatively low incidence of 3.2 per 100.000 (2). Reported etiology for precipitation of ON can be divided in to vascular, neurogenic, muscular, and osteogenic causes. The pathophysiology of occipital neuralgia is yet to be specified. The prevalent hypothesis is that it results from injury to the C2-C3 nerve roots and/or occipital nerves through various mechanisms such as vertebral instability, trauma, inflammation, entrapment etc. The onset of pain in occipital neuralgia is usually acute. It is described in various ways stabbing / shooting / electric shock like that starts in the nuchal region and spreads towards vertex. The episode may start spontaneously or precipitate by factors such as movement, combing of hair, exposure to cold etc. On palpation, the occipital nerve trunks may reveal local tenderness. Percussion over occipital nerve often reproduces the distribution of pain (Tinel’s Sign)(1). Diagnosis of ON is achieved with the help of above mentioned clinical manifestations. Cervicogenic headache, Trigeminal neuralgia and referred occipital pain may mimic clinical features of ON and need to be ruled out.
{"title":"Occipital neuralgia in lung carcinoma: A rare clinical scenario case report","authors":"Sovan Dhar Sarang, R. Sahoo, Z. Hossain, Majumdar Das Saroj, Dillip Kumar","doi":"10.2298/AOO180330002D","DOIUrl":"https://doi.org/10.2298/AOO180330002D","url":null,"abstract":"www.onk.ns.ac.rs/Archive • Volume 24 • Issue 1 • 2018 INTRODUCTION Occipital Neuralgia (ON) is characterised by sharp shooting pain arising in the sensory distribution of occipital nerves. Owing to be an uncommon diagnosis and at the same time due to overlap in criteria with more common neuralgias, its incidence and prevalence is rarely reported (1). A study in the Dutch general population reported a relatively low incidence of 3.2 per 100.000 (2). Reported etiology for precipitation of ON can be divided in to vascular, neurogenic, muscular, and osteogenic causes. The pathophysiology of occipital neuralgia is yet to be specified. The prevalent hypothesis is that it results from injury to the C2-C3 nerve roots and/or occipital nerves through various mechanisms such as vertebral instability, trauma, inflammation, entrapment etc. The onset of pain in occipital neuralgia is usually acute. It is described in various ways stabbing / shooting / electric shock like that starts in the nuchal region and spreads towards vertex. The episode may start spontaneously or precipitate by factors such as movement, combing of hair, exposure to cold etc. On palpation, the occipital nerve trunks may reveal local tenderness. Percussion over occipital nerve often reproduces the distribution of pain (Tinel’s Sign)(1). Diagnosis of ON is achieved with the help of above mentioned clinical manifestations. Cervicogenic headache, Trigeminal neuralgia and referred occipital pain may mimic clinical features of ON and need to be ruled out.","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":"156 1","pages":"10-11"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68402825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sukri Rahman, Histawara Subroto, J. Budiman, Aswiyanti Asri, Hafni Bachtiar
subcellular mechanism of the nasopharyngeal confirmed, but in several studies overexpression of the epidermal growth factor receptor was found. Based on histopathological classification, nonkeratinizing subtypes consisting of differentiated (WHO II) and undifferentiated (WHO III) are the most frequent types in endemic areas, whereas in non-endemic areas the majority of cases are keratinizing subtype (WHO I). The objective of this study was to evaluate the expression of epidermal growth factor receptor in advanced stage nonkeratinizing nasopharyngeal carcinoma as well as to evaluate difference in the expression between differentiated nonkeratinizing (WHO II) and undifferentiated (WHO III) nasopharyngeal carcinoma that may affect the anti-epidermal growth factor receptor therapy for nasopharyngeal carcinoma. Biopsies from 34 advance stage (stage III and stage IV) nonkeratinizing carcinoma consisting of 17 differentiated nonkeratinizing and 17 undifferentiated carcinomas of epidermal factor in investigated Our results demonstrated that epidermal growth factor receptor in 23 out of 34 subjects in differentiated nonkeratinizing carcinoma of in carcinoma histopathological subtypes (p=0.465). Conclusions: The epidermal growth factor receptor was expressed in most cases of advance stage nonkeratinizing nasopharyngeal carcinoma, and there was no difference in the expression between differentiated nonkeratinizing (WHO II) and undifferentiated nonkeratinizing nasopharyngeal carcinoma (WHO III).
{"title":"Expression of epidermal growth factor receptor in advance stage nonkeratinizing nasopharyngeal carcinoma in west Sumatra, Indonesia","authors":"Sukri Rahman, Histawara Subroto, J. Budiman, Aswiyanti Asri, Hafni Bachtiar","doi":"10.2298/AOO180401005R","DOIUrl":"https://doi.org/10.2298/AOO180401005R","url":null,"abstract":"subcellular mechanism of the nasopharyngeal confirmed, but in several studies overexpression of the epidermal growth factor receptor was found. Based on histopathological classification, nonkeratinizing subtypes consisting of differentiated (WHO II) and undifferentiated (WHO III) are the most frequent types in endemic areas, whereas in non-endemic areas the majority of cases are keratinizing subtype (WHO I). The objective of this study was to evaluate the expression of epidermal growth factor receptor in advanced stage nonkeratinizing nasopharyngeal carcinoma as well as to evaluate difference in the expression between differentiated nonkeratinizing (WHO II) and undifferentiated (WHO III) nasopharyngeal carcinoma that may affect the anti-epidermal growth factor receptor therapy for nasopharyngeal carcinoma. Biopsies from 34 advance stage (stage III and stage IV) nonkeratinizing carcinoma consisting of 17 differentiated nonkeratinizing and 17 undifferentiated carcinomas of epidermal factor in investigated Our results demonstrated that epidermal growth factor receptor in 23 out of 34 subjects in differentiated nonkeratinizing carcinoma of in carcinoma histopathological subtypes (p=0.465). Conclusions: The epidermal growth factor receptor was expressed in most cases of advance stage nonkeratinizing nasopharyngeal carcinoma, and there was no difference in the expression between differentiated nonkeratinizing (WHO II) and undifferentiated nonkeratinizing nasopharyngeal carcinoma (WHO III).","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":"24 1","pages":"20-23"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68402884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
as well as with maladaptive coping strategies (11-13). Those individuals high in negative affect generally manifest elevated levels of distress, anxiety, dissatisfaction, and a tendency toward focusing on the unpleasant aspects of themselves, other people, the world / life and the future (14). On the other hand, positive affect reflects the degree to which a person feels enthusiastic, active, confident and energetic (10). Positive affect is traditionally associated with subjective well-being and personal resources such as a supportive social network, optimism, adaptive coping strategies (15) and resilience in general. Negative and positive affect can be measured as both trait and state (16). is studies compared psychosocial outcomes of mastectomy and breast-conserving surgery found little differences in the presence of affective disorders between these two groups 18). Background. Breast cancer diagnosis is an extremely stressful life event that brings a number of physical and psychological challenges. Studies show that there is a high prevalence of psychological distress and symptoms of anxiety and depression among the diagnosed individuals. Although it is known that personality traits are strong predisposing factors for elevated experience of distress, research in oncology continues to be more focused on disease-related variables. In order to explore the role of personality traits in the experience of distress, the aim of our study was to examine the predictive value of personality characteristics such as neuroticism, hope, and optimism regarding the affective state of the patients after breast cancer surgery. Methods. The study was conducted on 40 women who had undergone breast cancer surgery, aged from 33 to 69 years (Mean = 55.02, SD = 9.18). The participants completed the following measures: Basic Demographic Data Questionnaire, The Positive and Negative Affect Schedule (PANAS), Life Orientation Test – Revised (LOT-R), Adult Hope Scale (AHS) and Neuroticism subscale from Big Five Inventory (BFI). Results. Two multiple regression analysis were performed, with the participants' age, level of hope, optimism and neuroticism as predictors and positive/negative affect as the criteria variables. In the first analysis, a statistically significant model was obtained (F 4, 35 = 3.05, p = 0.03), with optimism being the only significant predictor of positive affect. The second analysis also yields a statistically significant model (F 4, 35 = 3.32, p = 0.02), where neuroticism, and, marginally, optimism turned out to be significant predictors of negative affect. Conclusion. Our study showed that optimism and neuroticism may be important predictors of the affective state after breast cancer surgery. Therefore, it is important to include these factors in the screening batteries for early detection of vulnerable individuals and to take them into account when planning psychological interventions.
以及适应不良的应对策略(11-13)。那些负面情绪高的人通常表现出更高水平的痛苦、焦虑、不满，并倾向于关注自己、他人、世界/生活和未来的不愉快方面(14)。另一方面，积极影响反映了一个人感到热情、积极、自信和精力充沛的程度(10)。传统上，积极影响与主观幸福感和个人资源有关，如支持性社会网络、乐观主义、适应性应对策略(15)和一般的弹性。消极情感和积极情感可以作为特质和状态来衡量(16)。有研究比较了乳房切除术和保乳手术的心理社会结果，发现两组患者在情感障碍方面差异不大(18)。背景。乳腺癌诊断是一件极具压力的生活事件，会带来许多生理和心理上的挑战。研究表明，在被诊断的个体中，心理困扰和焦虑、抑郁症状的患病率很高。虽然众所周知，人格特征是增加痛苦体验的强烈诱发因素，但肿瘤学的研究仍然更多地关注与疾病相关的变量。为了探讨人格特质在乳腺癌术后痛苦体验中的作用，本研究旨在探讨神经质、希望、乐观等人格特质对乳腺癌术后患者情感状态的预测价值。方法。研究对象为40例接受过乳腺癌手术的女性，年龄33 ~ 69岁(Mean = 55.02, SD = 9.18)。研究对象完成了基本人口统计资料问卷、积极和消极情绪量表(PANAS)、人生取向修正测验(LOT-R)、成人希望量表(AHS)和大五人格量表(BFI)神经质量表。结果。以年龄、希望程度、乐观程度和神经质程度为预测因子，以积极/消极情绪为标准变量，进行两次多元回归分析。在第一次分析中，获得了具有统计学意义的模型(f4, 35 = 3.05, p = 0.03)，乐观是积极情绪的唯一显著预测因子。第二次分析也产生了一个统计上显著的模型(f4,35 = 3.32, p = 0.02)，其中神经质和乐观主义被证明是负面影响的显著预测因子。结论。我们的研究表明，乐观和神经质可能是乳腺癌手术后情感状态的重要预测因素。因此，重要的是要在筛选电池中包括这些因素，以便及早发现易受伤害的个体，并在计划心理干预时考虑到这些因素。
{"title":"Personality traits as predictors of the affective state in patients after breast cancer surgery","authors":"I. Novakov, S. Popović-Petrović","doi":"10.2298/AOO1701003N","DOIUrl":"https://doi.org/10.2298/AOO1701003N","url":null,"abstract":"as well as with maladaptive coping strategies (11-13). Those individuals high in negative affect generally manifest elevated levels of distress, anxiety, dissatisfaction, and a tendency toward focusing on the unpleasant aspects of themselves, other people, the world / life and the future (14). On the other hand, positive affect reflects the degree to which a person feels enthusiastic, active, confident and energetic (10). Positive affect is traditionally associated with subjective well-being and personal resources such as a supportive social network, optimism, adaptive coping strategies (15) and resilience in general. Negative and positive affect can be measured as both trait and state (16). is studies compared psychosocial outcomes of mastectomy and breast-conserving surgery found little differences in the presence of affective disorders between these two groups 18). Background. Breast cancer diagnosis is an extremely stressful life event that brings a number of physical and psychological challenges. Studies show that there is a high prevalence of psychological distress and symptoms of anxiety and depression among the diagnosed individuals. Although it is known that personality traits are strong predisposing factors for elevated experience of distress, research in oncology continues to be more focused on disease-related variables. In order to explore the role of personality traits in the experience of distress, the aim of our study was to examine the predictive value of personality characteristics such as neuroticism, hope, and optimism regarding the affective state of the patients after breast cancer surgery. Methods. The study was conducted on 40 women who had undergone breast cancer surgery, aged from 33 to 69 years (Mean = 55.02, SD = 9.18). The participants completed the following measures: Basic Demographic Data Questionnaire, The Positive and Negative Affect Schedule (PANAS), Life Orientation Test – Revised (LOT-R), Adult Hope Scale (AHS) and Neuroticism subscale from Big Five Inventory (BFI). Results. Two multiple regression analysis were performed, with the participants' age, level of hope, optimism and neuroticism as predictors and positive/negative affect as the criteria variables. In the first analysis, a statistically significant model was obtained (F 4, 35 = 3.05, p = 0.03), with optimism being the only significant predictor of positive affect. The second analysis also yields a statistically significant model (F 4, 35 = 3.32, p = 0.02), where neuroticism, and, marginally, optimism turned out to be significant predictors of negative affect. Conclusion. Our study showed that optimism and neuroticism may be important predictors of the affective state after breast cancer surgery. Therefore, it is important to include these factors in the screening batteries for early detection of vulnerable individuals and to take them into account when planning psychological interventions.","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":"23 1","pages":"3-8"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68402283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Liubota, M. Anikusko, O. Zotov, R. Vereshchako, I. Liubota
Isolated echinococcosis or hydatid cyst of breast is very rare disease especially in non-endemic areas. Even in endemic areas, hydatid cysts detects only for 0.27% of all cases of hydatidosis. Diagnosis of hydatid disease is difficult and it is diagnosed after surgical excision in majority cases. We report a case of 39 year old female with isolated hydatid cyst of the left breast that appeared as a painless breast lump without any specific symptoms.
{"title":"Isolated primary echinococcosis of breast: A rare case report","authors":"R. Liubota, M. Anikusko, O. Zotov, R. Vereshchako, I. Liubota","doi":"10.2298/AOO1701015L","DOIUrl":"https://doi.org/10.2298/AOO1701015L","url":null,"abstract":"Isolated echinococcosis or hydatid cyst of breast is very rare disease especially in non-endemic areas. Even in endemic areas, hydatid cysts detects only for 0.27% of all cases of hydatidosis. Diagnosis of hydatid disease is difficult and it is diagnosed after surgical excision in majority cases. We report a case of 39 year old female with isolated hydatid cyst of the left breast that appeared as a painless breast lump without any specific symptoms.","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":"23 1","pages":"15-16"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68402646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Nikolić, Filip Opincal, M. Ristanović, J. Trifunovic, S. Knežević, D. Radojkovic
{"title":"Analysis of smad4 gene promoter methylation in pancreatic and endometrial cancers","authors":"A. Nikolić, Filip Opincal, M. Ristanović, J. Trifunovic, S. Knežević, D. Radojkovic","doi":"10.2298/AOO1702017N","DOIUrl":"https://doi.org/10.2298/AOO1702017N","url":null,"abstract":"","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":"23 1","pages":"17-19"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68402717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Novaes, Rafaela Tristão e Silva, Ângela Mello Coelho, G. Fabri, Maria das Graças Afonso Miranda Chaves
effects, involving paraneoplastic mechanisms. Pain secondary to cancer therapy varies with the treatment modalities used: chemo-radiotherapy protocols are typically associated with painful mucositis and neurotoxicity. Surgical therapies often result in nerve and ABSTRACT Background: Oral complications of chemotherapy are sometimes unnoticed and if not treated, they can compromise patients’ health and quality of life. Methods: This study aimed to assess and characterize orofacial complaints and complications, and their impact on the oral-health-related quality of life in patients undergoing cancer chemotherapy. Results: We evaluated 28 patients with solid tumors undergoing chemotherapy, through a systematic orofacial evaluation. Eighteen patients (64.2%) developed oral complications during chemotherapy and xerostomia scored the highest incidence n = 14 (50%). About oral health data, gingival index revealed greater part of patients classified with moderate or severe gingival inflammation. The mean plaque index was 25.6%. The mean CPOD index was 15.48 and was worse in patients without oral complications. The patients presented higher plaque index and the oral health impact profile showed higher mean index in the patients group that developed oral complications. Conclusion: These data reinforce the crucial role of the dentist in the multidisciplinary team, with crucial suport in the diagnosis of oral complications. Thus, a specific assistance and relieve of patient’s complaints could impact positively on quality of life.
{"title":"Orofacial complaints and complications of chemotherapy","authors":"C. Novaes, Rafaela Tristão e Silva, Ângela Mello Coelho, G. Fabri, Maria das Graças Afonso Miranda Chaves","doi":"10.2298/aoo1701009n","DOIUrl":"https://doi.org/10.2298/aoo1701009n","url":null,"abstract":"effects, involving paraneoplastic mechanisms. Pain secondary to cancer therapy varies with the treatment modalities used: chemo-radiotherapy protocols are typically associated with painful mucositis and neurotoxicity. Surgical therapies often result in nerve and ABSTRACT Background: Oral complications of chemotherapy are sometimes unnoticed and if not treated, they can compromise patients’ health and quality of life. Methods: This study aimed to assess and characterize orofacial complaints and complications, and their impact on the oral-health-related quality of life in patients undergoing cancer chemotherapy. Results: We evaluated 28 patients with solid tumors undergoing chemotherapy, through a systematic orofacial evaluation. Eighteen patients (64.2%) developed oral complications during chemotherapy and xerostomia scored the highest incidence n = 14 (50%). About oral health data, gingival index revealed greater part of patients classified with moderate or severe gingival inflammation. The mean plaque index was 25.6%. The mean CPOD index was 15.48 and was worse in patients without oral complications. The patients presented higher plaque index and the oral health impact profile showed higher mean index in the patients group that developed oral complications. Conclusion: These data reinforce the crucial role of the dentist in the multidisciplinary team, with crucial suport in the diagnosis of oral complications. Thus, a specific assistance and relieve of patient’s complaints could impact positively on quality of life.","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":"23 1","pages":"9-14"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68402982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Lovrenski, D. Tegeltija, I. Jeličić, Milorad Bijelović, D. Ðuric, Milana Panjković
Background. Thymomas are rare neoplasms arising from tissue elements of the thymus. The objective of the study was to analyse clinical characteristics of patients with thymoma, as well as morphological and patohistological features of neoplasms. Methods: Retrospectively we studied 41 medical records and patohistological material of patients reffered to the Institute for pulmonary diseases of Vojvodina between the January 2005 and December 2014. Results: Patient age at presentation ranged from 19 to 77 years. A slight female preponderance was detected, with 24 (58.5%) females and 17 (41.5%) males being affected. All types of thymoma more often occured in males, accept subtype B1. Patients with type A thymoma and subtype B1 were mainly asymptomatic, while patients with subtype B2 and type AB presented with dyspnea, dysphagia, pain and cough. Myasthenia gravis often was associated with type A (40%). The most common histologic type was subtype B1. Twenty three (56%) patients had a tumor diameter between 5 and 10 cm. Five patients had malignant thymoma, and the most common types of thymoma that showed signs of capsula invasion or pleural and pericardial implants were type AB (60%) and subtype B2 (50%). Biopsies of suspected tissue were obtained through a sternotomy, video-assisted thoracoscopy surgery, and video-assisted mini thoracotomy, and after setting a diagnosis on ex tempore analysis, the lesions were removed by thymectomy or extirpation of the tumor mass. Conclusion: Thymomas have variable clinical presentations. Clinical outcome correlates with histological type, size and clinical stage, as well as the ability to achieve complete tumor resection.
{"title":"Evaluation of clinical, morphological and pathohistological characteristics of thymomas - our ten year experience","authors":"A. Lovrenski, D. Tegeltija, I. Jeličić, Milorad Bijelović, D. Ðuric, Milana Panjković","doi":"10.2298/AOO1702020L","DOIUrl":"https://doi.org/10.2298/AOO1702020L","url":null,"abstract":"Background. Thymomas are rare neoplasms arising from tissue elements of the thymus. The objective of the study was to analyse clinical characteristics of patients with thymoma, as well as morphological and patohistological features of neoplasms. Methods: Retrospectively we studied 41 medical records and patohistological material of patients reffered to the Institute for pulmonary diseases of Vojvodina between the January 2005 and December 2014. Results: Patient age at presentation ranged from 19 to 77 years. A slight female preponderance was detected, with 24 (58.5%) females and 17 (41.5%) males being affected. All types of thymoma more often occured in males, accept subtype B1. Patients with type A thymoma and subtype B1 were mainly asymptomatic, while patients with subtype B2 and type AB presented with dyspnea, dysphagia, pain and cough. Myasthenia gravis often was associated with type A (40%). The most common histologic type was subtype B1. Twenty three (56%) patients had a tumor diameter between 5 and 10 cm. Five patients had malignant thymoma, and the most common types of thymoma that showed signs of capsula invasion or pleural and pericardial implants were type AB (60%) and subtype B2 (50%). Biopsies of suspected tissue were obtained through a sternotomy, video-assisted thoracoscopy surgery, and video-assisted mini thoracotomy, and after setting a diagnosis on ex tempore analysis, the lesions were removed by thymectomy or extirpation of the tumor mass. Conclusion: Thymomas have variable clinical presentations. Clinical outcome correlates with histological type, size and clinical stage, as well as the ability to achieve complete tumor resection.","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":"23 1","pages":"20-24"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68402730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marina Ðokic-Lisanin, V. Pantović, Z. Jovanović, G. Samardžić, V. Jurišić
Background: Alkaline phosphatase is a glycoprotein that catalyzes two kinds of chemical reactions: hydrolysis of phosphorus ester breaking P-O bonds and phospho-transfer reactions in which phosphoric group is transferred to an acceptor molecule. In the human body, ALP exists in multiple molecular forms whose heterogeneity is partly due to genetic factors and partly to posttranslational modifications. The aim was to evaluate a total ALP activity and its isoforms in cancer patients with bone and liver metastasis in comparison to healthy controls. Methods: Human serum was collected from 20 healthy individuals, and 20 cancer patients with bone and liver metastases, with metastases confirmed by ultrasound, computerized tomography and a radiology scan. Determination of ALP was done by the endpoint spectrophotometric method. Isoenzymes were determined by heat inactivation method. Results: In cancer patients, the total ALP activity was significantly higher (p< 0.05) compared to healthy controls. In the sera of cancer patients with liver metastases, the remaining ALP activity was two-fold higher in comparison to bone metastases. Conclusion: Determination of ALP isoenzymes is important but a correct clinical interpretation in the context of other analyses is vital for a proper diagnosis of a disease. [Projekat Ministarstva nauke Republike Srbije, br.175056]
{"title":"Values of alkaline phosphathase and their isoenzyme profiles in patients with cancer in respect to bone and liver metastasis","authors":"Marina Ðokic-Lisanin, V. Pantović, Z. Jovanović, G. Samardžić, V. Jurišić","doi":"10.2298/AOO1301014D","DOIUrl":"https://doi.org/10.2298/AOO1301014D","url":null,"abstract":"Background: Alkaline phosphatase is a glycoprotein that catalyzes two kinds of chemical reactions: hydrolysis of phosphorus ester breaking P-O bonds and phospho-transfer reactions in which phosphoric group is transferred to an acceptor molecule. In the human body, ALP exists in multiple molecular forms whose heterogeneity is partly due to genetic factors and partly to posttranslational modifications. The aim was to evaluate a total ALP activity and its isoforms in cancer patients with bone and liver metastasis in comparison to healthy controls. Methods: Human serum was collected from 20 healthy individuals, and 20 cancer patients with bone and liver metastases, with metastases confirmed by ultrasound, computerized tomography and a radiology scan. Determination of ALP was done by the endpoint spectrophotometric method. Isoenzymes were determined by heat inactivation method. Results: In cancer patients, the total ALP activity was significantly higher (p< 0.05) compared to healthy controls. In the sera of cancer patients with liver metastases, the remaining ALP activity was two-fold higher in comparison to bone metastases. Conclusion: Determination of ALP isoenzymes is important but a correct clinical interpretation in the context of other analyses is vital for a proper diagnosis of a disease. [Projekat Ministarstva nauke Republike Srbije, br.175056]","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":"21 1","pages":"14-16"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2298/AOO1301014D","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68401640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Standard therapy of HER2-positive and triple negative metastatic breast cancer - present and future","authors":"J. Trifunović, J. Pešić","doi":"10.2298/AOO1304163T","DOIUrl":"https://doi.org/10.2298/AOO1304163T","url":null,"abstract":"","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":"21 1","pages":"163-167"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68402204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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