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Expression of epidermal growth factor receptor in advance stage nonkeratinizing nasopharyngeal carcinoma in west Sumatra, Indonesia 印尼西苏门答腊晚期非角化性鼻咽癌中表皮生长因子受体的表达
Q4 Medicine Pub Date : 2018-01-01 DOI: 10.2298/AOO180401005R
Sukri Rahman, Histawara Subroto, J. Budiman, Aswiyanti Asri, Hafni Bachtiar
subcellular mechanism of the nasopharyngeal confirmed, but in several studies overexpression of the epidermal growth factor receptor was found. Based on histopathological classification, nonkeratinizing subtypes consisting of differentiated (WHO II) and undifferentiated (WHO III) are the most frequent types in endemic areas, whereas in non-endemic areas the majority of cases are keratinizing subtype (WHO I). The objective of this study was to evaluate the expression of epidermal growth factor receptor in advanced stage nonkeratinizing nasopharyngeal carcinoma as well as to evaluate difference in the expression between differentiated nonkeratinizing (WHO II) and undifferentiated (WHO III) nasopharyngeal carcinoma that may affect the anti-epidermal growth factor receptor therapy for nasopharyngeal carcinoma. Biopsies from 34 advance stage (stage III and stage IV) nonkeratinizing carcinoma consisting of 17 differentiated nonkeratinizing and 17 undifferentiated carcinomas of epidermal factor in investigated Our results demonstrated that epidermal growth factor receptor in 23 out of 34 subjects in differentiated nonkeratinizing carcinoma of in carcinoma histopathological subtypes (p=0.465). Conclusions: The epidermal growth factor receptor was expressed in most cases of advance stage nonkeratinizing nasopharyngeal carcinoma, and there was no difference in the expression between differentiated nonkeratinizing (WHO II) and undifferentiated nonkeratinizing nasopharyngeal carcinoma (WHO III).
鼻咽部的亚细胞机制得到证实,但在一些研究中发现表皮生长因子受体过表达。根据组织病理学分类,由分化型(WHO II)和未分化型(WHO III)组成的非角化亚型是流行地区最常见的类型。而在非流行地区,大多数病例为角化亚型(WHO I)。本研究的目的是评估晚期非角化鼻咽癌中表皮生长因子受体的表达,并评估分化非角化鼻咽癌(WHO II)和未分化鼻咽癌(WHO III)之间表达的差异,这可能影响抗表皮生长因子受体治疗鼻咽癌。34例晚期(III期和IV期)非角化癌的活检,包括17例分化的非角化癌和17例未分化的表皮因子癌。我们的研究结果表明,34例分化的非角化癌的组织病理学亚型中有23例存在表皮生长因子受体(p=0.465)。结论:表皮生长因子受体在大多数晚期非角化鼻咽癌中均有表达,分化型非角化鼻咽癌(WHO II)与未分化型非角化鼻咽癌(WHO III)的表达无差异。
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引用次数: 4
Personality traits as predictors of the affective state in patients after breast cancer surgery 人格特质作为乳腺癌术后患者情感状态的预测因子
Q4 Medicine Pub Date : 2017-01-01 DOI: 10.2298/AOO1701003N
I. Novakov, S. Popović-Petrović
as well as with maladaptive coping strategies (11-13). Those individuals high in negative affect generally manifest elevated levels of distress, anxiety, dissatisfaction, and a tendency toward focusing on the unpleasant aspects of themselves, other people, the world / life and the future (14). On the other hand, positive affect reflects the degree to which a person feels enthusiastic, active, confident and energetic (10). Positive affect is traditionally associated with subjective well-being and personal resources such as a supportive social network, optimism, adaptive coping strategies (15) and resilience in general. Negative and positive affect can be measured as both trait and state (16). is studies compared psychosocial outcomes of mastectomy and breast-conserving surgery found little differences in the presence of affective disorders between these two groups 18). Background. Breast cancer diagnosis is an extremely stressful life event that brings a number of physical and psychological challenges. Studies show that there is a high prevalence of psychological distress and symptoms of anxiety and depression among the diagnosed individuals. Although it is known that personality traits are strong predisposing factors for elevated experience of distress, research in oncology continues to be more focused on disease-related variables. In order to explore the role of personality traits in the experience of distress, the aim of our study was to examine the predictive value of personality characteristics such as neuroticism, hope, and optimism regarding the affective state of the patients after breast cancer surgery. Methods. The study was conducted on 40 women who had undergone breast cancer surgery, aged from 33 to 69 years (Mean = 55.02, SD = 9.18). The participants completed the following measures: Basic Demographic Data Questionnaire, The Positive and Negative Affect Schedule (PANAS), Life Orientation Test – Revised (LOT-R), Adult Hope Scale (AHS) and Neuroticism subscale from Big Five Inventory (BFI). Results. Two multiple regression analysis were performed, with the participants' age, level of hope, optimism and neuroticism as predictors and positive/negative affect as the criteria variables. In the first analysis, a statistically significant model was obtained (F 4, 35 = 3.05, p = 0.03), with optimism being the only significant predictor of positive affect. The second analysis also yields a statistically significant model (F 4, 35 = 3.32, p = 0.02), where neuroticism, and, marginally, optimism turned out to be significant predictors of negative affect. Conclusion. Our study showed that optimism and neuroticism may be important predictors of the affective state after breast cancer surgery. Therefore, it is important to include these factors in the screening batteries for early detection of vulnerable individuals and to take them into account when planning psychological interventions.
以及适应不良的应对策略(11-13)。那些负面情绪高的人通常表现出更高水平的痛苦、焦虑、不满,并倾向于关注自己、他人、世界/生活和未来的不愉快方面(14)。另一方面,积极影响反映了一个人感到热情、积极、自信和精力充沛的程度(10)。传统上,积极影响与主观幸福感和个人资源有关,如支持性社会网络、乐观主义、适应性应对策略(15)和一般的弹性。消极情感和积极情感可以作为特质和状态来衡量(16)。有研究比较了乳房切除术和保乳手术的心理社会结果,发现两组患者在情感障碍方面差异不大(18)。背景。乳腺癌诊断是一件极具压力的生活事件,会带来许多生理和心理上的挑战。研究表明,在被诊断的个体中,心理困扰和焦虑、抑郁症状的患病率很高。虽然众所周知,人格特征是增加痛苦体验的强烈诱发因素,但肿瘤学的研究仍然更多地关注与疾病相关的变量。为了探讨人格特质在乳腺癌术后痛苦体验中的作用,本研究旨在探讨神经质、希望、乐观等人格特质对乳腺癌术后患者情感状态的预测价值。方法。研究对象为40例接受过乳腺癌手术的女性,年龄33 ~ 69岁(Mean = 55.02, SD = 9.18)。研究对象完成了基本人口统计资料问卷、积极和消极情绪量表(PANAS)、人生取向修正测验(LOT-R)、成人希望量表(AHS)和大五人格量表(BFI)神经质量表。结果。以年龄、希望程度、乐观程度和神经质程度为预测因子,以积极/消极情绪为标准变量,进行两次多元回归分析。在第一次分析中,获得了具有统计学意义的模型(f4, 35 = 3.05, p = 0.03),乐观是积极情绪的唯一显著预测因子。第二次分析也产生了一个统计上显著的模型(f4,35 = 3.32, p = 0.02),其中神经质和乐观主义被证明是负面影响的显著预测因子。结论。我们的研究表明,乐观和神经质可能是乳腺癌手术后情感状态的重要预测因素。因此,重要的是要在筛选电池中包括这些因素,以便及早发现易受伤害的个体,并在计划心理干预时考虑到这些因素。
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引用次数: 4
Isolated primary echinococcosis of breast: A rare case report 孤立性原发性乳腺包虫病1例报告
Q4 Medicine Pub Date : 2017-01-01 DOI: 10.2298/AOO1701015L
R. Liubota, M. Anikusko, O. Zotov, R. Vereshchako, I. Liubota
Isolated echinococcosis or hydatid cyst of breast is very rare disease especially in non-endemic areas. Even in endemic areas, hydatid cysts detects only for 0.27% of all cases of hydatidosis. Diagnosis of hydatid disease is difficult and it is diagnosed after surgical excision in majority cases. We report a case of 39 year old female with isolated hydatid cyst of the left breast that appeared as a painless breast lump without any specific symptoms.
孤立性乳腺包虫病或包虫病是一种非常罕见的疾病,特别是在非流行地区。即使在流行地区,包虫病的检出率也仅为0.27%。包虫病的诊断是困难的,大多数病例是在手术切除后诊断的。我们报告一例39岁女性左乳孤立包虫病,表现为无痛性乳房肿块,无任何特殊症状。
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引用次数: 0
Analysis of smad4 gene promoter methylation in pancreatic and endometrial cancers 胰腺癌和子宫内膜癌smad4基因启动子甲基化分析
Q4 Medicine Pub Date : 2017-01-01 DOI: 10.2298/AOO1702017N
A. Nikolić, Filip Opincal, M. Ristanović, J. Trifunovic, S. Knežević, D. Radojkovic
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引用次数: 1
Orofacial complaints and complications of chemotherapy 口腔面部疾病和化疗并发症
Q4 Medicine Pub Date : 2017-01-01 DOI: 10.2298/aoo1701009n
C. Novaes, Rafaela Tristão e Silva, Ângela Mello Coelho, G. Fabri, Maria das Graças Afonso Miranda Chaves
effects, involving paraneoplastic mechanisms. Pain secondary to cancer therapy varies with the treatment modalities used: chemo-radiotherapy protocols are typically associated with painful mucositis and neurotoxicity. Surgical therapies often result in nerve and ABSTRACT Background: Oral complications of chemotherapy are sometimes unnoticed and if not treated, they can compromise patients’ health and quality of life. Methods: This study aimed to assess and characterize orofacial complaints and complications, and their impact on the oral-health-related quality of life in patients undergoing cancer chemotherapy. Results: We evaluated 28 patients with solid tumors undergoing chemotherapy, through a systematic orofacial evaluation. Eighteen patients (64.2%) developed oral complications during chemotherapy and xerostomia scored the highest incidence n = 14 (50%). About oral health data, gingival index revealed greater part of patients classified with moderate or severe gingival inflammation. The mean plaque index was 25.6%. The mean CPOD index was 15.48 and was worse in patients without oral complications. The patients presented higher plaque index and the oral health impact profile showed higher mean index in the patients group that developed oral complications. Conclusion: These data reinforce the crucial role of the dentist in the multidisciplinary team, with crucial suport in the diagnosis of oral complications. Thus, a specific assistance and relieve of patient’s complaints could impact positively on quality of life.
影响,涉及副肿瘤机制。癌症治疗后继发的疼痛因治疗方式的不同而不同:化疗-放疗方案通常与疼痛性粘膜炎和神经毒性有关。背景:化疗的口腔并发症有时会被忽视,如果不及时治疗,它们会危及患者的健康和生活质量。方法:本研究旨在评估和描述癌症化疗患者的口面部主诉和并发症,以及它们对口腔健康相关生活质量的影响。结果:我们评估了28例接受化疗的实体瘤患者,通过系统的口腔面部评估。化疗期间出现口腔并发症18例(64.2%),其中发生率最高的为口干症14例(50%)。关于口腔健康数据,牙龈指数显示大部分患者分为中度或重度牙龈炎症。平均斑块指数为25.6%。平均CPOD指数为15.48,无口腔并发症患者的CPOD指数更差。出现口腔并发症的患者斑块指数较高,口腔健康影响谱的平均指数也较高。结论:这些数据加强了牙医在多学科团队中的关键作用,对口腔并发症的诊断提供了重要支持。因此,一个具体的帮助和减轻病人的抱怨可以积极影响生活质量。
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引用次数: 0
Evaluation of clinical, morphological and pathohistological characteristics of thymomas - our ten year experience 胸腺瘤的临床、形态学和病理组织学特征的评价——我们十年的经验
Q4 Medicine Pub Date : 2017-01-01 DOI: 10.2298/AOO1702020L
A. Lovrenski, D. Tegeltija, I. Jeličić, Milorad Bijelović, D. Ðuric, Milana Panjković
Background. Thymomas are rare neoplasms arising from tissue elements of the thymus. The objective of the study was to analyse clinical characteristics of patients with thymoma, as well as morphological and patohistological features of neoplasms. Methods: Retrospectively we studied 41 medical records and patohistological material of patients reffered to the Institute for pulmonary diseases of Vojvodina between the January 2005 and December 2014. Results: Patient age at presentation ranged from 19 to 77 years. A slight female preponderance was detected, with 24 (58.5%) females and 17 (41.5%) males being affected. All types of thymoma more often occured in males, accept subtype B1. Patients with type A thymoma and subtype B1 were mainly asymptomatic, while patients with subtype B2 and type AB presented with dyspnea, dysphagia, pain and cough. Myasthenia gravis often was associated with type A (40%). The most common histologic type was subtype B1. Twenty three (56%) patients had a tumor diameter between 5 and 10 cm. Five patients had malignant thymoma, and the most common types of thymoma that showed signs of capsula invasion or pleural and pericardial implants were type AB (60%) and subtype B2 (50%). Biopsies of suspected tissue were obtained through a sternotomy, video-assisted thoracoscopy surgery, and video-assisted mini thoracotomy, and after setting a diagnosis on ex tempore analysis, the lesions were removed by thymectomy or extirpation of the tumor mass. Conclusion: Thymomas have variable clinical presentations. Clinical outcome correlates with histological type, size and clinical stage, as well as the ability to achieve complete tumor resection.
背景。胸腺瘤是一种罕见的肿瘤,起源于胸腺的组织成分。本研究的目的是分析胸腺瘤患者的临床特征,以及肿瘤的形态和病理组织学特征。方法:回顾性分析2005年1月至2014年12月在伏伊伏丁那省肺病研究所就诊的41例患者的病历和病理组织学资料。结果:患者发病年龄19 ~ 77岁。女性有轻微优势,女性24例(58.5%),男性17例(41.5%)。所有类型的胸腺瘤多见于男性,接受B1亚型。A型胸腺瘤和B1亚型患者主要无症状,B2亚型和AB型患者表现为呼吸困难、吞咽困难、疼痛和咳嗽。重症肌无力常伴有A型(40%)。最常见的组织学类型为B1亚型。23例(56%)患者肿瘤直径在5 ~ 10cm之间。5例患者有恶性胸腺瘤,最常见的胸腺瘤类型为AB型(60%)和B2亚型(50%)。通过胸骨切开术、电视胸腔镜手术和电视辅助小开胸术对可疑组织进行活检,经临时分析诊断后,通过胸腺切除术或切除肿瘤块切除病变。结论:胸腺瘤具有多种临床表现。临床结果与肿瘤的组织学类型、大小、临床分期以及肿瘤完全切除的能力有关。
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引用次数: 0
Values of alkaline phosphathase and their isoenzyme profiles in patients with cancer in respect to bone and liver metastasis 碱性磷酸酶及其同工酶谱在肿瘤骨和肝转移中的价值
Q4 Medicine Pub Date : 2013-01-01 DOI: 10.2298/AOO1301014D
Marina Ðokic-Lisanin, V. Pantović, Z. Jovanović, G. Samardžić, V. Jurišić
Background: Alkaline phosphatase is a glycoprotein that catalyzes two kinds of chemical reactions: hydrolysis of phosphorus ester breaking P-O bonds and phospho-transfer reactions in which phosphoric group is transferred to an acceptor molecule. In the human body, ALP exists in multiple molecular forms whose heterogeneity is partly due to genetic factors and partly to posttranslational modifications. The aim was to evaluate a total ALP activity and its isoforms in cancer patients with bone and liver metastasis in comparison to healthy controls. Methods: Human serum was collected from 20 healthy individuals, and 20 cancer patients with bone and liver metastases, with metastases confirmed by ultrasound, computerized tomography and a radiology scan. Determination of ALP was done by the endpoint spectrophotometric method. Isoenzymes were determined by heat inactivation method. Results: In cancer patients, the total ALP activity was significantly higher (p< 0.05) compared to healthy controls. In the sera of cancer patients with liver metastases, the remaining ALP activity was two-fold higher in comparison to bone metastases. Conclusion: Determination of ALP isoenzymes is important but a correct clinical interpretation in the context of other analyses is vital for a proper diagnosis of a disease. [Projekat Ministarstva nauke Republike Srbije, br.175056]
背景:碱性磷酸酶是一种糖蛋白,它催化两种化学反应:磷酸酯水解破坏P-O键和磷酸基团转移到受体分子的磷酸转移反应。在人体内,ALP以多种分子形式存在,其异质性部分是由于遗传因素,部分是由于翻译后修饰。目的是评估骨和肝转移的癌症患者与健康对照者的总ALP活性及其亚型。方法:采集20例健康人血清和20例经超声、计算机断层扫描和放射学扫描证实为骨转移和肝转移的肿瘤患者血清。用终点分光光度法测定ALP。用热失活法测定同工酶。结果:肿瘤患者总ALP活性显著高于健康对照组(p< 0.05)。在肝转移癌患者的血清中,剩余的ALP活性是骨转移癌患者的两倍。结论:ALP同工酶的测定是重要的,但在其他分析的背景下,正确的临床解释对于疾病的正确诊断至关重要。[Srbije, br.175056]
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引用次数: 5
Standard therapy of HER2-positive and triple negative metastatic breast cancer - present and future her2阳性和三阴性转移性乳腺癌的标准治疗-现在和未来
Q4 Medicine Pub Date : 2013-01-01 DOI: 10.2298/AOO1304163T
J. Trifunović, J. Pešić
{"title":"Standard therapy of HER2-positive and triple negative metastatic breast cancer - present and future","authors":"J. Trifunović, J. Pešić","doi":"10.2298/AOO1304163T","DOIUrl":"https://doi.org/10.2298/AOO1304163T","url":null,"abstract":"","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68402204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sclerosing hemangioma of the lung 肺硬化性血管瘤
Q4 Medicine Pub Date : 2013-01-01 DOI: 10.2298/aoo1304133t
D. Tegeltija, A. Lovrenski, M. Milić, Miloš Koledin, Milana Panjković
{"title":"Sclerosing hemangioma of the lung","authors":"D. Tegeltija, A. Lovrenski, M. Milić, Miloš Koledin, Milana Panjković","doi":"10.2298/aoo1304133t","DOIUrl":"https://doi.org/10.2298/aoo1304133t","url":null,"abstract":"","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68402493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 32
Eight years after introducing liver resection at the Oncology Institute of Vojvodina 在伏伊伏丁那肿瘤研究所引入肝脏切除术八年后
Q4 Medicine Pub Date : 2013-01-01 DOI: 10.2298/AOO1304101M
I. Majdevac, N. Budišin, M. Ranisavljevic, D. Lukić, Imre Lovas, N. Šolajić
{"title":"Eight years after introducing liver resection at the Oncology Institute of Vojvodina","authors":"I. Majdevac, N. Budišin, M. Ranisavljevic, D. Lukić, Imre Lovas, N. Šolajić","doi":"10.2298/AOO1304101M","DOIUrl":"https://doi.org/10.2298/AOO1304101M","url":null,"abstract":"","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68402160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Archive of Oncology
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