Milica Bojanic, D. Radovanovic, S. Zahorjanski, Svetlana Škorić-Jokić, M. Protić
Retroperitoneal liposarcoma is a rare type of tumor characterized by slow growth and nonspecific symptoms, and is usually diagnosed at an advanced stage. Patients with huge retroperitoneal liposarcoma have a high risk of developing perioperative complications, and require special preoperative preparation and a carefully planned anesthetic approach. We present the case of a 57-year-old man, who was diagnosed with a huge retroperitoneal liposarcoma, 70 cm in diameter, weighing 30.4 kg and planned for surgical resection of the tumor under general anesthesia. Perioperative treatment and anesthesia for this patient were a great challenge for the anesthesiologist. However, due to preoperative preparation, monitoring and fluid replacement, hemodynamic and respiratory stability of the patient was maintained perioperatively.
{"title":"A patient with large retroperitoneal liposarcoma - a challenge for an anesthesiologist","authors":"Milica Bojanic, D. Radovanovic, S. Zahorjanski, Svetlana Škorić-Jokić, M. Protić","doi":"10.2298/aoo210617001b","DOIUrl":"https://doi.org/10.2298/aoo210617001b","url":null,"abstract":"Retroperitoneal liposarcoma is a rare type of tumor characterized by slow growth and nonspecific symptoms, and is usually diagnosed at an advanced stage. Patients with huge retroperitoneal liposarcoma have a high risk of developing perioperative complications, and require special preoperative preparation and a carefully planned anesthetic approach. We present the case of a 57-year-old man, who was diagnosed with a huge retroperitoneal liposarcoma, 70 cm in diameter, weighing 30.4 kg and planned for surgical resection of the tumor under general anesthesia. Perioperative treatment and anesthesia for this patient were a great challenge for the anesthesiologist. However, due to preoperative preparation, monitoring and fluid replacement, hemodynamic and respiratory stability of the patient was maintained perioperatively.","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68403434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. M. S. D. Silva, E. Queiroga, Cynthia A. B. de Toledo Osório, Karin S. Cunha, Eliane P. Dias
Received 2021-04-03 Received in revised form 2021-06-14 Accepted 2021-06-14 INTRODUCTION Cancer is currently recognized as a complex disease composed of several cell types, especially those derived from the surrounding mesenchymal stroma, with which neoplastic cells establish the tumor microenvironment (TME). In this environment, the tumor stroma represents one of the TME components (1–4). Tumor cells explore their stroma, changing its composition in a bi-directional communication, leading to the stromatogenesis. The interaction pathways are varied and complex. Therefore, the stromal tissue is not a passive component that involves the tumor (5). Studies have shown that tumor stroma plays a relevant and diverse role in tumorigenesis, acting in different stages: it facilitates the survival and proliferation of neoplastic cells; promotes epithelial-mesenchymal transition, and local and metastatic spread (6–12). Even in distant and lymph node metastatic sites, stromal components accompany cancer cells (13, 14). In malignant epithelial tumors, the scoring system based on the evaluation of the tumor-stroma proportion (TSP) in sections stained with hematoxylin and eosin (H&E) has been shown to be a good prognostic tool (9,10,15–18). Several international research groups have demonstrated that high amount of stroma contributes to a more aggressive tumor phenotypes (8, 9, 15–17, 19–21). Their goal was to fill the need for and identify new prognostic characteristics that could be used along with the current pathological staging (8, 20). The traditional tumor, lymph node and metastasis (TNM) system that has been used routinely for prognosis estimate and guidance of treatment for certain types of tumors (22, 23), lacks accuracy (21, 24, 25). In colorectal cancer (CRC), new reliable biomarkers are needed to guide personalized treatment (21) since current pathological variables only moderately indicate possible outcome and response to therapy (6, 19, 21). Currently, CRC represents a serious public health problem worldwide, occupying the third place in terms of incidence and the second place in mortality numbers (22), while being little attended by public policies in underdeveloped or developing countries (26). Although the complete biological role of stroma is not yet fully understood (20), in the last 10 years the evaluation of tumor stroma has gained interest due to its simplicity and, above all, to its clinical value as a potential prognostic factor. Furthermore, cancer cells and stroma are being considered as therapeutic targets in treatment strategies for solid tumors (14), in which the quantification of the stromal component may provide additional risk stratification for adaptation to neoadjuvant and adjuvant treatments (8, 15, 20, 27). The aim of this study was to evaluate the relevance of the tumor-stroma proportion and its association with confirmed aggressive phenotypes in a large series of patients diagnosed with cancer of the right/left colon and r
{"title":"Stromal scoring in advanced colon and rectal cancer: Stroma-rich tumors and their association with aggressive phenotypes","authors":"R. M. S. D. Silva, E. Queiroga, Cynthia A. B. de Toledo Osório, Karin S. Cunha, Eliane P. Dias","doi":"10.2298/AOO210403003S","DOIUrl":"https://doi.org/10.2298/AOO210403003S","url":null,"abstract":"Received 2021-04-03 Received in revised form 2021-06-14 Accepted 2021-06-14 INTRODUCTION Cancer is currently recognized as a complex disease composed of several cell types, especially those derived from the surrounding mesenchymal stroma, with which neoplastic cells establish the tumor microenvironment (TME). In this environment, the tumor stroma represents one of the TME components (1–4). Tumor cells explore their stroma, changing its composition in a bi-directional communication, leading to the stromatogenesis. The interaction pathways are varied and complex. Therefore, the stromal tissue is not a passive component that involves the tumor (5). Studies have shown that tumor stroma plays a relevant and diverse role in tumorigenesis, acting in different stages: it facilitates the survival and proliferation of neoplastic cells; promotes epithelial-mesenchymal transition, and local and metastatic spread (6–12). Even in distant and lymph node metastatic sites, stromal components accompany cancer cells (13, 14). In malignant epithelial tumors, the scoring system based on the evaluation of the tumor-stroma proportion (TSP) in sections stained with hematoxylin and eosin (H&E) has been shown to be a good prognostic tool (9,10,15–18). Several international research groups have demonstrated that high amount of stroma contributes to a more aggressive tumor phenotypes (8, 9, 15–17, 19–21). Their goal was to fill the need for and identify new prognostic characteristics that could be used along with the current pathological staging (8, 20). The traditional tumor, lymph node and metastasis (TNM) system that has been used routinely for prognosis estimate and guidance of treatment for certain types of tumors (22, 23), lacks accuracy (21, 24, 25). In colorectal cancer (CRC), new reliable biomarkers are needed to guide personalized treatment (21) since current pathological variables only moderately indicate possible outcome and response to therapy (6, 19, 21). Currently, CRC represents a serious public health problem worldwide, occupying the third place in terms of incidence and the second place in mortality numbers (22), while being little attended by public policies in underdeveloped or developing countries (26). Although the complete biological role of stroma is not yet fully understood (20), in the last 10 years the evaluation of tumor stroma has gained interest due to its simplicity and, above all, to its clinical value as a potential prognostic factor. Furthermore, cancer cells and stroma are being considered as therapeutic targets in treatment strategies for solid tumors (14), in which the quantification of the stromal component may provide additional risk stratification for adaptation to neoadjuvant and adjuvant treatments (8, 15, 20, 27). The aim of this study was to evaluate the relevance of the tumor-stroma proportion and its association with confirmed aggressive phenotypes in a large series of patients diagnosed with cancer of the right/left colon and r","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68403410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Dugandžija, Marijana Sreckovic, V. Ignjatovic, Snezana Panic, Igor Dragičević, Natasa Hinic
Objectives: Our goal was to conduct the first survey and screening of colon cancer incidence trends in the Macva district, Serbia. Methods: Age-specific incidence of colon cancer among the > 20 years old adults that were diagnosed from 2006-2015 was analyzed using data from Cancer Registries of the Sabac Public Health Institute and Public Health Institute of Serbia. Linear model of the incidence rates and annual change in age-standardized incidence rates, by sex and age were presented. Standardized incidence ratio, based on average age-specific incidence rates of colon cancer for Sabac municipality and Central Serbia was calculated. Results: Based on the results from our study, colon cancer incidence in Sabac municipality increased in males and females in the last ten years. Risk of developing colon cancer in males and females, calculated by standardized rates ratios was 1.5 and 1.3, respectively. Linear, rising trend for age-standardized incidence rates in the population of Sabac compared to other municipalities in the Macva district was recorded. Furthermore, standardized incidence ratios for both females and males were higher compared to data from Central Serbia (28% and 22%, respectively). Conclusion: Our study revealed increased colon cancer incidence, with a linear increase of colon cancers in young males and also in > 50 years old population.
{"title":"Trends in colon cancer incidence in young and older adults in Macva region (Serbia)","authors":"T. Dugandžija, Marijana Sreckovic, V. Ignjatovic, Snezana Panic, Igor Dragičević, Natasa Hinic","doi":"10.2298/aoo210205005d","DOIUrl":"https://doi.org/10.2298/aoo210205005d","url":null,"abstract":"Objectives: Our goal was to conduct the first survey and screening of colon cancer incidence trends in the Macva district, Serbia. Methods: Age-specific incidence of colon cancer among the > 20 years old adults that were diagnosed from 2006-2015 was analyzed using data from Cancer Registries of the Sabac Public Health Institute and Public Health Institute of Serbia. Linear model of the incidence rates and annual change in age-standardized incidence rates, by sex and age were presented. Standardized incidence ratio, based on average age-specific incidence rates of colon cancer for Sabac municipality and Central Serbia was calculated. Results: Based on the results from our study, colon cancer incidence in Sabac municipality increased in males and females in the last ten years. Risk of developing colon cancer in males and females, calculated by standardized rates ratios was 1.5 and 1.3, respectively. Linear, rising trend for age-standardized incidence rates in the population of Sabac compared to other municipalities in the Macva district was recorded. Furthermore, standardized incidence ratios for both females and males were higher compared to data from Central Serbia (28% and 22%, respectively). Conclusion: Our study revealed increased colon cancer incidence, with a linear increase of colon cancers in young males and also in > 50 years old population.","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68403360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vladimir Čančar, Radenko Ivanovic, Nenad Lalović, Biljana Milinković, D. P. Sladoje
Paraovarian cysts originate from the mesothelium and are presumed to be remnants of M?llerian or Wolffian ducts. In majority of cases they are found to be 10-80 mm in diameter and do not cause any symptoms. Paraovarian cysts can be found unexpectedly during an operation or on ultrasound examination performed for other reasons. They are most freequently discovered on ultrasound examination. However, due to the proximity of the ovary for which cystic formations are not rare, the diagnosis of these lesions can be a challenge. They are mostly asymptomatic and only large lesions (?20 cm in diameter) become symptomatic. Although these are mostly benign tumors, in rare cases they can become borderline or true malignancies. Most paraovarian cysts are found in the third and fourth decade of life. Paraovarian cyst complications include: compression of the surrounding structures of the pelvis minor and abdomen, pelvic pain, cyst torsion and rupture. Except for the already mensioned complications available literature has so far failed to show cases of uterine prolapse caused by an increase of intra-abdominal pressure due to the expansive growth of giant paraovarian cystic formation.
{"title":"Paraovarian cyst as the cause of uterine prolapse","authors":"Vladimir Čančar, Radenko Ivanovic, Nenad Lalović, Biljana Milinković, D. P. Sladoje","doi":"10.2298/aoo190528001c","DOIUrl":"https://doi.org/10.2298/aoo190528001c","url":null,"abstract":"Paraovarian cysts originate from the mesothelium and are presumed to be remnants of M?llerian or Wolffian ducts. In majority of cases they are found to be 10-80 mm in diameter and do not cause any symptoms. Paraovarian cysts can be found unexpectedly during an operation or on ultrasound examination performed for other reasons. They are most freequently discovered on ultrasound examination. However, due to the proximity of the ovary for which cystic formations are not rare, the diagnosis of these lesions can be a challenge. They are mostly asymptomatic and only large lesions (?20 cm in diameter) become symptomatic. Although these are mostly benign tumors, in rare cases they can become borderline or true malignancies. Most paraovarian cysts are found in the third and fourth decade of life. Paraovarian cyst complications include: compression of the surrounding structures of the pelvis minor and abdomen, pelvic pain, cyst torsion and rupture. Except for the already mensioned complications available literature has so far failed to show cases of uterine prolapse caused by an increase of intra-abdominal pressure due to the expansive growth of giant paraovarian cystic formation.","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68402635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Bapayeva, M. Terzic, K. Togyzbayeva, A. Bekenova, S. Terzic, S. Garzon, Giovanni Falzone, B. Aitbayeva
Pheochromocytomas are rare tumors producing catecholamines that could be a cause of secondary hypertension. On that basis, pheochromocytoma can occur as an extremely rare cause of hypertension in pregnancy and if diagnosed late can lead to adverse maternal-fetal outcome. In this case report we describe a case of pheochromocytoma affected pregnancy with poor fetal outcome. A 27-year-old pregnant woman was admitted for severe pre-eclampsia due to pre-gestational hypertension that was diagnosed during the first trimester. Due to high and uncontrolled maternal blood pressure and the worsened maternal-fetal condition after the admission induction of fetal lung maturity and emergency cesarean section were performed, but with poor fetal outcome. Later, an adrenal gland mass was identified using abdominal ultrasound and confirmed by computed tomography. After surgical adrenalectomy blood pressure of the patient was normalized. Pheochromocytoma should be considered as a possible cause of hypertensive disorder during pregnancy, particularly in cases of severe and unresponsive hypertension in order to provide for timely and appropriate treatment.
{"title":"Late diagnosis of pheochromocytoma in pregnancy with poor fetal outcome","authors":"G. Bapayeva, M. Terzic, K. Togyzbayeva, A. Bekenova, S. Terzic, S. Garzon, Giovanni Falzone, B. Aitbayeva","doi":"10.2298/aoo191012002b","DOIUrl":"https://doi.org/10.2298/aoo191012002b","url":null,"abstract":"Pheochromocytomas are rare tumors producing catecholamines that could be a cause of secondary hypertension. On that basis, pheochromocytoma can occur as an extremely rare cause of hypertension in pregnancy and if diagnosed late can lead to adverse maternal-fetal outcome. In this case report we describe a case of pheochromocytoma affected pregnancy with poor fetal outcome. A 27-year-old pregnant woman was admitted for severe pre-eclampsia due to pre-gestational hypertension that was diagnosed during the first trimester. Due to high and uncontrolled maternal blood pressure and the worsened maternal-fetal condition after the admission induction of fetal lung maturity and emergency cesarean section were performed, but with poor fetal outcome. Later, an adrenal gland mass was identified using abdominal ultrasound and confirmed by computed tomography. After surgical adrenalectomy blood pressure of the patient was normalized. Pheochromocytoma should be considered as a possible cause of hypertensive disorder during pregnancy, particularly in cases of severe and unresponsive hypertension in order to provide for timely and appropriate treatment.","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68403089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Andjelic, Bojana Scepanovic, S. Salma, D. Kozic, Natasa Prvulovic-Bunovic
We present the case of a 39-years old man who underwent three surgeries because of spinal ependymoma located in cauda equina region. He presented at the Oncology Institute of Vojvodina for combined adjuvant chemo- and radiotherapy after the second surgery. An MRI examination performed after six cycles of therapy showed no signs of disease. 26 months later, a follow-up MRI showed recurrence of disease in the form of small drop metastasis. Six months later, the patient underwent the third surgery. The patient is currently receiving another cycle of radiotherapy, and is scheduled for additional cycles of chemotherapy. Ependymomas are the most common spinal cord malignancy in adults. The symptoms are nonspecific which often causes a delay in diagnosis. An MRI examination of the spine with contrast admission is the study of choice for detecting spinal cord masses. Surgery is the first-line therapy for ependymomas. Recurrence rate is associated with the extent of surgical resection, with en bloc and gross-total resection being associated with lower rates of disease recurrence. In children under 3 years, adjuvant chemotherapy is advocated, while older children and adults undergo adjuvant radiotherapy or combined chemo- and radiotherapy in cases of subtotal resection or tumor recurrence.
{"title":"A case of recurring spinal ependymoma in 37-years old man after surgery and adjuvant therapy","authors":"N. Andjelic, Bojana Scepanovic, S. Salma, D. Kozic, Natasa Prvulovic-Bunovic","doi":"10.2298/aoo200214004a","DOIUrl":"https://doi.org/10.2298/aoo200214004a","url":null,"abstract":"We present the case of a 39-years old man who underwent three surgeries because of spinal ependymoma located in cauda equina region. He presented at the Oncology Institute of Vojvodina for combined adjuvant chemo- and radiotherapy after the second surgery. An MRI examination performed after six cycles of therapy showed no signs of disease. 26 months later, a follow-up MRI showed recurrence of disease in the form of small drop metastasis. Six months later, the patient underwent the third surgery. The patient is currently receiving another cycle of radiotherapy, and is scheduled for additional cycles of chemotherapy. Ependymomas are the most common spinal cord malignancy in adults. The symptoms are nonspecific which often causes a delay in diagnosis. An MRI examination of the spine with contrast admission is the study of choice for detecting spinal cord masses. Surgery is the first-line therapy for ependymomas. Recurrence rate is associated with the extent of surgical resection, with en bloc and gross-total resection being associated with lower rates of disease recurrence. In children under 3 years, adjuvant chemotherapy is advocated, while older children and adults undergo adjuvant radiotherapy or combined chemo- and radiotherapy in cases of subtotal resection or tumor recurrence.","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68403137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Vasilchenko, V. Braginsky, Vitaly Rynk, A. Osintsev
This article describes a method for non-contact local hyperthermal heating of patient's tissue using inductive electromagnetic radiation. The aim of the study was a theoretical and experimental assessment of the thermal and electromagnetic parameters of the proposed method based on heating of intraoperatively administered, personal, tissue-replacing applicator using induction magnetic field. Theoretical estimates of the thermal and electromagnetic parameters of this method were performed based on heat conduction equations. An experimental study of the process was carried out using originally designed laboratory inverter and confirmed theoretical calculations.
{"title":"Use of hyperthermal heating and intraoperatively administered applicator for the treatment of local malignant tumors","authors":"I. Vasilchenko, V. Braginsky, Vitaly Rynk, A. Osintsev","doi":"10.2298/aoo210518004v","DOIUrl":"https://doi.org/10.2298/aoo210518004v","url":null,"abstract":"This article describes a method for non-contact local hyperthermal heating of patient's tissue using inductive electromagnetic radiation. The aim of the study was a theoretical and experimental assessment of the thermal and electromagnetic parameters of the proposed method based on heating of intraoperatively administered, personal, tissue-replacing applicator using induction magnetic field. Theoretical estimates of the thermal and electromagnetic parameters of this method were performed based on heat conduction equations. An experimental study of the process was carried out using originally designed laboratory inverter and confirmed theoretical calculations.","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68403426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tamara Djuricic, A. Mandić, B. Gutic, Natasa Prvulovic-Bunovic, N. Stanulovic
Choriocarcinoma is a subtype of gestational trophoblastic disease. It is a very rare neoplasm, with incidence of about 1 case in 40.000 pregnancies. Gestational form of choriocarcinoma arises most commonly after abortion, while nongestational form develops from pluripotent germ cells. Choricarcinoma is highly malignant and highly chemosensitive type of tumor. A 43-year-old patient diagnosed with extra uterine pregnancy in September 2017 was treated with methotrexate with no response and had surgical removal of right Fallopian tube. Choriocarcinoma was diagnosed one and a half year after extra uterine pregnancy. Radiological imaging before treatment showed pulmonary and inguinal lymph node metastases and tumor invasion of the anterior uterine wall. Surgery was performed due to heavy bleeding and uterine wall invasion. As high risk patient she received chemotherapy. She was followed radiologically and her serum ?-HCG was monitored. Refractivity to the chemotherapy protocol during treatment was observed. Therapy response was achieved after administration of EMA-EP protocol modification i.e. three consecutive negative follow-up values of ?-HCG were obtained and radiological findings were disease free. One month after treatment patient had no signs of disease and ?-HCG level was normal.
{"title":"Adjuvant chemotherapy of resistant high risk choriocarcinoma","authors":"Tamara Djuricic, A. Mandić, B. Gutic, Natasa Prvulovic-Bunovic, N. Stanulovic","doi":"10.2298/aoo200408005d","DOIUrl":"https://doi.org/10.2298/aoo200408005d","url":null,"abstract":"Choriocarcinoma is a subtype of gestational trophoblastic disease. It is a very rare neoplasm, with incidence of about 1 case in 40.000 pregnancies. Gestational form of choriocarcinoma arises most commonly after abortion, while nongestational form develops from pluripotent germ cells. Choricarcinoma is highly malignant and highly chemosensitive type of tumor. A 43-year-old patient diagnosed with extra uterine pregnancy in September 2017 was treated with methotrexate with no response and had surgical removal of right Fallopian tube. Choriocarcinoma was diagnosed one and a half year after extra uterine pregnancy. Radiological imaging before treatment showed pulmonary and inguinal lymph node metastases and tumor invasion of the anterior uterine wall. Surgery was performed due to heavy bleeding and uterine wall invasion. As high risk patient she received chemotherapy. She was followed radiologically and her serum ?-HCG was monitored. Refractivity to the chemotherapy protocol during treatment was observed. Therapy response was achieved after administration of EMA-EP protocol modification i.e. three consecutive negative follow-up values of ?-HCG were obtained and radiological findings were disease free. One month after treatment patient had no signs of disease and ?-HCG level was normal.","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68403148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Djermanovic, Z. Radovanovic, D. Lukić, Mladen Ðuric, D. Golijanin, M. Ranisavljevic, Nemanja Petrovic
Introduction: The development of laparoscopic colorectal surgery began in 1991. Today, laparoscopic surgery presents standard approach in the surgical treatment of malignant colon and rectal diseases. Aim: Surgical and oncological outcomes and survival rates of laparoscopic colorectal surgery at the Oncology Institute of Vojvodina. Methods: Data were collected prospectively from 66 patients undergoing laparoscopic colorectal surgery between December 2009 and December 2019. Registered data included sex, age, surgical indication and type for the procedure, indication and reason for conversion to open surgery, operative time, performing temporary or permanent stoma, intraoperative bowel perforation, pathologic TNM grade, number of harvested lymph nodes, inclusion of positive resection margin, number of postoperative days at the hospital, postoperative complications, postoperative mortality, presence of distant metastases and survival rates. Results: Laparoscopic procedures were right hemicolectomy in 11/66 (16.7%), left hemicolectomy in 1/66 (1.5%), sigmoid colectomy in 19/66 (28.8%), high anterior rectal resection in 13/66 (19.7%), low anterior rectal resection in 12/66 (18.2%), abdominoperineal amputation of the rectum in 7/66 (10.6%), colectomy in 2/66 (3%) and proctocolectomy in 1/66 (1.5%) patient. The median follow-up was 37.5 months (range 6 to 128). The total number of surviving patients was 60 (90.9%). Conclusion: This study showed that laparoscopic colorectal surgery has good clinical and oncological outcomes.
{"title":"A single institutional experience in laparoscopic colorectal surgery: Clinical and oncological outcomes over 10 years","authors":"A. Djermanovic, Z. Radovanovic, D. Lukić, Mladen Ðuric, D. Golijanin, M. Ranisavljevic, Nemanja Petrovic","doi":"10.2298/aoo200728006d","DOIUrl":"https://doi.org/10.2298/aoo200728006d","url":null,"abstract":"Introduction: The development of laparoscopic colorectal surgery began in 1991. Today, laparoscopic surgery presents standard approach in the surgical treatment of malignant colon and rectal diseases. Aim: Surgical and oncological outcomes and survival rates of laparoscopic colorectal surgery at the Oncology Institute of Vojvodina. Methods: Data were collected prospectively from 66 patients undergoing laparoscopic colorectal surgery between December 2009 and December 2019. Registered data included sex, age, surgical indication and type for the procedure, indication and reason for conversion to open surgery, operative time, performing temporary or permanent stoma, intraoperative bowel perforation, pathologic TNM grade, number of harvested lymph nodes, inclusion of positive resection margin, number of postoperative days at the hospital, postoperative complications, postoperative mortality, presence of distant metastases and survival rates. Results: Laparoscopic procedures were right hemicolectomy in 11/66 (16.7%), left hemicolectomy in 1/66 (1.5%), sigmoid colectomy in 19/66 (28.8%), high anterior rectal resection in 13/66 (19.7%), low anterior rectal resection in 12/66 (18.2%), abdominoperineal amputation of the rectum in 7/66 (10.6%), colectomy in 2/66 (3%) and proctocolectomy in 1/66 (1.5%) patient. The median follow-up was 37.5 months (range 6 to 128). The total number of surviving patients was 60 (90.9%). Conclusion: This study showed that laparoscopic colorectal surgery has good clinical and oncological outcomes.","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68403198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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