Background: Liver function test (LFT) is a routine laboratory examination used in the diagnosis of many disorders, the liver participates in several essential functions in the human body, and liver dysfunction can lead to morbidity and mortality. Therefore, studying the levels of LFT in untreated cancer patients can identify how the liver perform when cancer begins, and which parameter of LFT is affected early. Objective: This study aimed to evaluate levels of LFT including alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), albumin, total bilirubin (T bilirubin), direct bilirubin (D bilirubin), and total protein (T pro-tein), in untreated cancer patients. Design: Cross-sectional retrospective. Settings: Taif city- king Faisal Hospital (KFH) and Taif university. Patients and methods: Serum levels of ALT, AST, ALP, T protein, T bilirubin, D bilirubin, and albumin were evaluated. 256 Participants were included in this study and 30 were healthy participants. Cancer patients were as follows, gastroin- testinal tract cancer patients were 59, breast cancer patients were 45, gynecological tumors were 50, head and neck cancer patients were 20, blood tumor patients were 28, and urogenital tract patients were 24. Statistical analysis applied were T-test, Chi-square, odds ratio, and relative risk. Sample size: 256 participants were 30 healthy controls and 226 untreated cancer patients. Results: Hypoproteinemia was highly detected as 44% of patients demonstrated hypoalbuminemia and 22.2% of patients have low levels in T protein. AST, ALT, and ALP showed significant increase in patients than healthy control. Conclusion: Hypoproteinemia can be used as a prognostic marker of liver dysfunction in untreated cancer patients.
{"title":"Evaluation of liver function show hypoproteinemia in untreated cancer patients: A cross-sectional study","authors":"M. Almehmadi","doi":"10.4993/acrt.28.63","DOIUrl":"https://doi.org/10.4993/acrt.28.63","url":null,"abstract":"Background: Liver function test (LFT) is a routine laboratory examination used in the diagnosis of many disorders, the liver participates in several essential functions in the human body, and liver dysfunction can lead to morbidity and mortality. Therefore, studying the levels of LFT in untreated cancer patients can identify how the liver perform when cancer begins, and which parameter of LFT is affected early. Objective: This study aimed to evaluate levels of LFT including alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), albumin, total bilirubin (T bilirubin), direct bilirubin (D bilirubin), and total protein (T pro-tein), in untreated cancer patients. Design: Cross-sectional retrospective. Settings: Taif city- king Faisal Hospital (KFH) and Taif university. Patients and methods: Serum levels of ALT, AST, ALP, T protein, T bilirubin, D bilirubin, and albumin were evaluated. 256 Participants were included in this study and 30 were healthy participants. Cancer patients were as follows, gastroin- testinal tract cancer patients were 59, breast cancer patients were 45, gynecological tumors were 50, head and neck cancer patients were 20, blood tumor patients were 28, and urogenital tract patients were 24. Statistical analysis applied were T-test, Chi-square, odds ratio, and relative risk. Sample size: 256 participants were 30 healthy controls and 226 untreated cancer patients. Results: Hypoproteinemia was highly detected as 44% of patients demonstrated hypoalbuminemia and 22.2% of patients have low levels in T protein. AST, ALT, and ALP showed significant increase in patients than healthy control. Conclusion: Hypoproteinemia can be used as a prognostic marker of liver dysfunction in untreated cancer patients.","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49517142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Rezapour, H. Bouzarjomehri, Akhtar Shah-Savandi, Emad Karimianrad, N. Pirani, J. Arabloo, Samira Soleimanpoor, Y. Herandi
Background: Mammography as the best method of diagnosing breast cancer in its early stages has been accepted in many countries. Digital mammography is in development and is used in breast cancer screening in countries such as the United States, however, cost-effectiveness of digital mammography screening (DMS) compared to film mammography screening (FMS) is debatable. This study is designed to systematically review the available evidence in this regard. Methods: This study is designed as a systematic review using PRISMA guidelines. The search was conducted on October 2019 on the PubMed, Web of Science core collection, Embase, Scopus, Cochrane library and ProQuest databases. All full economic evaluation studies (cost-effectiveness analysis (CEA), cost-utility analysis (CUA), and cost-benefit analysis (CBA)) that assessed DMS compared to FMS are included. The quality of final articles were evaluated by CHEERS checklist and data was collected using a data extraction form. Finally, the data was analyzed by a meta-synthesis method. Results: Five studies were included. Three of them were conducted in the U.S., one in the Australia, and one the Brazil. Studies show that despite the slight difference in the effectiveness of DMS, its costs increased more. Three studies concluded that age-targeted DMS and FMS might be cost-effective and two concluded biennial DMS might be cost-effective digital strategy, however one study concluded that biennial FMS is still cost-effective. Conclusion: There is currently little evidence on the cost-effectiveness of DMS over FMS and more evidence is needed, especially in developing countries. While the cost-effectiveness of DMS has not been fully confirmed, manufacturers are developing digital mammography; on the other hand, film mammography is obsoleting. Therefore, the move towards digital mammography, especially in developing countries, should be gradual and targeted.
背景：乳腺造影术作为诊断癌症早期的最佳方法，已被许多国家所接受。在美国等国家，数字乳房X光检查正在发展中，并被用于癌症乳腺筛查，然而，与胶片乳房X光筛查（FMS）相比，数字乳腺X光检查（DMS）的成本效益是有争议的。本研究旨在系统地审查这方面的现有证据。方法：本研究采用PRISMA指南进行系统综述。搜索于2019年10月在PubMed、Web of Science核心收藏、Embase、Scopus、Cochrane图书馆和ProQuest数据库上进行。包括所有评估DMS与FMS的全面经济评估研究（成本效益分析（CEA）、成本效用分析（CUA）和成本效益分析）。使用CHEERS检查表对最终文章的质量进行评估，并使用数据提取表收集数据。最后，使用综合方法对数据进行分析。结果：纳入5项研究。其中三次在美国进行，一次在澳大利亚，一次是在巴西。研究表明，尽管DMS的有效性略有差异，但其成本增加更多。三项研究得出结论，针对年龄的DMS和FMS可能具有成本效益，两项研究得出的结论是，两年期DMS可能是具有成本效益的数字战略，但一项研究得出得出结论，两年期FMS仍然具有成本效益。结论：目前很少有证据表明DMS相对于FMS的成本效益，需要更多的证据，尤其是在发展中国家。虽然DMS的成本效益尚未得到充分证实，但制造商正在开发数字乳房X光检查；另一方面，钼靶x线片已经过时了。因此，数字化乳房X光检查的发展，特别是在发展中国家，应该是渐进的和有针对性的。
{"title":"Cost-effectiveness of digital mammography compared to film mammography in screening of breast cancer: a systematic review","authors":"A. Rezapour, H. Bouzarjomehri, Akhtar Shah-Savandi, Emad Karimianrad, N. Pirani, J. Arabloo, Samira Soleimanpoor, Y. Herandi","doi":"10.4993/acrt.28.118","DOIUrl":"https://doi.org/10.4993/acrt.28.118","url":null,"abstract":"Background: Mammography as the best method of diagnosing breast cancer in its early stages has been accepted in many countries. Digital mammography is in development and is used in breast cancer screening in countries such as the United States, however, cost-effectiveness of digital mammography screening (DMS) compared to film mammography screening (FMS) is debatable. This study is designed to systematically review the available evidence in this regard. Methods: This study is designed as a systematic review using PRISMA guidelines. The search was conducted on October 2019 on the PubMed, Web of Science core collection, Embase, Scopus, Cochrane library and ProQuest databases. All full economic evaluation studies (cost-effectiveness analysis (CEA), cost-utility analysis (CUA), and cost-benefit analysis (CBA)) that assessed DMS compared to FMS are included. The quality of final articles were evaluated by CHEERS checklist and data was collected using a data extraction form. Finally, the data was analyzed by a meta-synthesis method. Results: Five studies were included. Three of them were conducted in the U.S., one in the Australia, and one the Brazil. Studies show that despite the slight difference in the effectiveness of DMS, its costs increased more. Three studies concluded that age-targeted DMS and FMS might be cost-effective and two concluded biennial DMS might be cost-effective digital strategy, however one study concluded that biennial FMS is still cost-effective. Conclusion: There is currently little evidence on the cost-effectiveness of DMS over FMS and more evidence is needed, especially in developing countries. While the cost-effectiveness of DMS has not been fully confirmed, manufacturers are developing digital mammography; on the other hand, film mammography is obsoleting. Therefore, the move towards digital mammography, especially in developing countries, should be gradual and targeted.","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41430217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Almehmadi, Khalid J. Alzahrani, M. Salih, Abdulaziz Alsharif, N. Alsiwiehri, Alaa Shafie, Abdulraheem A Almalki, A. Alhazmi, Haytham Dahlawi, M. Alharthi, M. Halawi, Abdulrhman M. Almehmadi, Hatem H. Allam
Background: Vitamin D roles in human health and wellbeing have been extensively studied in the recent years. It has essential roles in homeostasis and maintaining many physiological functions. These roles are vital in immune system, respiratory system, cardiovascular system, and reproductive system. Deficiency in this vitamin has been correlated with many diseases in the body, and it has been correlated with developing cancer. Objective: This study aimed to investigate levels of total vitamin D (25-hydroxycholecalciferol) in cancer patients. Design: Retrospective. Settings: Taif city- king Faisal Hospital (KFH). Patients and methods: Serum levels of 25-hydroxycholecalciferol were classified into normal, insufficient, and deficiency group, patients were grouped according to these classes.156 patients were included in this study, 128 females and 28 males, 100 healthy participants were included. Cancer patients were as follows, gastrointestinal tract cancer patients were 27, breast cancer patients were 73, female genital tract patients were 43, head and neck cancer patients were 6 and respiratory tract patients were 7. Sample size: 256 participants were 100 healthy controls and 156 cancer patients. Results: Deficiency was detected in most of the patients from both genders, and in both pre- and post-menopausal female patients. Conclusion: These findings support the belief that deficiency in vitamin D is a risk factor leading to development of cancer.
{"title":"Prevalence of vitamin D deficiency in early-diagnosed cancer patients: A cross-sectional study","authors":"M. Almehmadi, Khalid J. Alzahrani, M. Salih, Abdulaziz Alsharif, N. Alsiwiehri, Alaa Shafie, Abdulraheem A Almalki, A. Alhazmi, Haytham Dahlawi, M. Alharthi, M. Halawi, Abdulrhman M. Almehmadi, Hatem H. Allam","doi":"10.4993/acrt.28.54","DOIUrl":"https://doi.org/10.4993/acrt.28.54","url":null,"abstract":"Background: Vitamin D roles in human health and wellbeing have been extensively studied in the recent years. It has essential roles in homeostasis and maintaining many physiological functions. These roles are vital in immune system, respiratory system, cardiovascular system, and reproductive system. Deficiency in this vitamin has been correlated with many diseases in the body, and it has been correlated with developing cancer. Objective: This study aimed to investigate levels of total vitamin D (25-hydroxycholecalciferol) in cancer patients. Design: Retrospective. Settings: Taif city- king Faisal Hospital (KFH). Patients and methods: Serum levels of 25-hydroxycholecalciferol were classified into normal, insufficient, and deficiency group, patients were grouped according to these classes.156 patients were included in this study, 128 females and 28 males, 100 healthy participants were included. Cancer patients were as follows, gastrointestinal tract cancer patients were 27, breast cancer patients were 73, female genital tract patients were 43, head and neck cancer patients were 6 and respiratory tract patients were 7. Sample size: 256 participants were 100 healthy controls and 156 cancer patients. Results: Deficiency was detected in most of the patients from both genders, and in both pre- and post-menopausal female patients. Conclusion: These findings support the belief that deficiency in vitamin D is a risk factor leading to development of cancer.","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49369955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Shidei, T. Kono, R. Imaizumi, T. Koike, Hideyuki Yokokawa, Yoshitomo Ito, Yuta Miyano, K. Oyama, S. Shiozawa, K. Yoshimatsu
Low-grade appendiceal mucinous neoplasm (LAMN) is a rare disease. The strategy of treatment for LAMN has not been established. We herein present a case of LAMN treated by laparoscopic ileocecal resection with D2 lymph node (LN) dissection, which exhibited invagination. A 59-year-old man visited at our emergency room with intermittent abdominal pain. Abdomino-pelvic computed tomography (CT) revealed suspiciously a diagnosis as intussusception of LAMN into the ascending colon. Emergency laparoscopic operation was performed. A laparoscopic ileocecal resection with D2 LN dissection was performed because swollen lymph nodes were notified around the ileocolic artery. Histologically, he was diagnosed as LAMN, T3, N0, M0, Stage
{"title":"A case of low grade appendiceal mucinous neoplasm performed with laparoscopic ileocecal resection due to intussusception","authors":"H. Shidei, T. Kono, R. Imaizumi, T. Koike, Hideyuki Yokokawa, Yoshitomo Ito, Yuta Miyano, K. Oyama, S. Shiozawa, K. Yoshimatsu","doi":"10.4993/acrt.28.60","DOIUrl":"https://doi.org/10.4993/acrt.28.60","url":null,"abstract":"Low-grade appendiceal mucinous neoplasm (LAMN) is a rare disease. The strategy of treatment for LAMN has not been established. We herein present a case of LAMN treated by laparoscopic ileocecal resection with D2 lymph node (LN) dissection, which exhibited invagination. A 59-year-old man visited at our emergency room with intermittent abdominal pain. Abdomino-pelvic computed tomography (CT) revealed suspiciously a diagnosis as intussusception of LAMN into the ascending colon. Emergency laparoscopic operation was performed. A laparoscopic ileocecal resection with D2 LN dissection was performed because swollen lymph nodes were notified around the ileocolic artery. Histologically, he was diagnosed as LAMN, T3, N0, M0, Stage","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46945387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Melanotic neuroectodermal tumour of infancy (MNTI) is rare, rapidly growing, pigmented neoplasm of neural crest origin. It is generally accepted as a benign tumour despite of its rapid and locally destructive growth. It primarily affects the maxilla of infants during the first year of life. Surgical excision is considered as the treatment of choice. The recurrence rate varies between 10% and 15%, and malignant behaviour has been reported in 6.5% of cases. We report a 15-month old male who presented with a 2-month history of a rapidly growing mass in the anterior. A biopsy showed melanotic neuroectodermal tumor, and complete resection with negative margins was subsequently achieved.
{"title":"Surgical Management of Melanotic Neuroectodermal Tumor of Infancy: A case Report","authors":"H. L. Nguyen, H. Phan, H. S. Nguyen","doi":"10.4993/acrt.28.168","DOIUrl":"https://doi.org/10.4993/acrt.28.168","url":null,"abstract":"Melanotic neuroectodermal tumour of infancy (MNTI) is rare, rapidly growing, pigmented neoplasm of neural crest origin. It is generally accepted as a benign tumour despite of its rapid and locally destructive growth. It primarily affects the maxilla of infants during the first year of life. Surgical excision is considered as the treatment of choice. The recurrence rate varies between 10% and 15%, and malignant behaviour has been reported in 6.5% of cases. We report a 15-month old male who presented with a 2-month history of a rapidly growing mass in the anterior. A biopsy showed melanotic neuroectodermal tumor, and complete resection with negative margins was subsequently achieved.","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43867559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Yunusova, T. Aoyama, Yulduz Khodjibekova, S. Mamarajabov, A. Khasanov, J. Sakamoto, Elmira Baykhodjaeva
Cystic masses of the neck are relatively frequent developmental defects. Surgery is the only effective treatment. Early intervention is usually recommended to avoid complications. These three signs: the presence of internal septae, irregular walls and a solid component were combined into an assessment SIST SCORE (septae + irregular wall + solid components = TGDC SCORE). This study was also undertaken to assess the possible application of ultrasound in the differentiation of cysts of the neck.
{"title":"Differentiation of cystic lesions of neck","authors":"L. Yunusova, T. Aoyama, Yulduz Khodjibekova, S. Mamarajabov, A. Khasanov, J. Sakamoto, Elmira Baykhodjaeva","doi":"10.4993/acrt.28.129","DOIUrl":"https://doi.org/10.4993/acrt.28.129","url":null,"abstract":"Cystic masses of the neck are relatively frequent developmental defects. Surgery is the only effective treatment. Early intervention is usually recommended to avoid complications. These three signs: the presence of internal septae, irregular walls and a solid component were combined into an assessment SIST SCORE (septae + irregular wall + solid components = TGDC SCORE). This study was also undertaken to assess the possible application of ultrasound in the differentiation of cysts of the neck.","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47247826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Madoka Ogikubo, I. Yamazaki, R. Izubuchi, Taku Masuda, S. Isoda, M. Masuda
In rare cases, malignant lymphoma may invade the aorta and mimic other aortic diseases; thus, it is sometimes difficult to diagnose from image examinations. In such patients, aortic disease may also be caused by degeneration of the aortic wall or necrosis due to chemotherapy. We present the case of a 78-year-old man who was initially diagnosed with an aneurysm or tumor adjacent to the aorta, in which open surgery was required for replacement of the abdominal main vessel. We discuss treatments for malignant lymphoma invading the aorta with reference to previous reports.
{"title":"A case of malignant lymphoma invading the aorta, which mimicked aortic dissection","authors":"Madoka Ogikubo, I. Yamazaki, R. Izubuchi, Taku Masuda, S. Isoda, M. Masuda","doi":"10.4993/acrt.28.164","DOIUrl":"https://doi.org/10.4993/acrt.28.164","url":null,"abstract":"In rare cases, malignant lymphoma may invade the aorta and mimic other aortic diseases; thus, it is sometimes difficult to diagnose from image examinations. In such patients, aortic disease may also be caused by degeneration of the aortic wall or necrosis due to chemotherapy. We present the case of a 78-year-old man who was initially diagnosed with an aneurysm or tumor adjacent to the aorta, in which open surgery was required for replacement of the abdominal main vessel. We discuss treatments for malignant lymphoma invading the aorta with reference to previous reports.","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44630857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Salih, B. Elesawy, Salman M. Al-Ayli, Awad A. Al-Otaibi, Fares M. Al-Thobiti, M. Almehmadi
Background: Colorectal carcinoma is the second most common malignancy among Saudis. Cells derived from many hu- man malignant tissues have altered chromatin content and structure. The cellular Feulgen DNA content of malignant tissues is typically altered. Here we investigate the relationship between nuclear DNA content in colorectal carcinoma. Objectives: To demonstrate DNA in colorectal cancer cells using Feulgen reaction, and to determine the association between colon cancer grade and cellular DNA content. Design: Retrospective. Settings: Taif city- King Abdul Aziz specialized hospital. Patients and methods: Sections were stained with the Hematoxylin and Eosin method and the Feulgen reaction method for DNA demonstration. Sample size: Paraffin sections from 50 patients previously diagnosed with colon cancer were included in this study. Results: The histopathological diagnosis showed that 82% were adenocarcinoma cases, 18% had benign tumors. Regarding cancer grading, 56% of cases had moderately differentiated adenocarcinoma, 18% had low differentiated adenocarcinoma, 6% had high differentiated adenocarcinoma, and 2% had poorly differentiated adenocarcinoma. The staining intensity of the Feulgen reaction showed that 46% of tissue sections had intense staining, 22% had medium staining, and 14% had results comparable to control staining. We detected no significant associations between the cancer grade and age group, gender, or result of Feulgen reaction. Conclusion: DNA demonstration using the Feulgen reaction is a simple and successfully estimated in this study. However, the correlations between DNA staining and several clinicopathological factors were not statistically significant. We recommend that DNA staining should be combined with routine histopathological examination for better understanding of patients’ clinical malignant potential of the colorectal cancer.
{"title":"Demonstration of Deoxyribonucleic Acid in Colorectal Cancer Using Feulgen reaction","authors":"M. Salih, B. Elesawy, Salman M. Al-Ayli, Awad A. Al-Otaibi, Fares M. Al-Thobiti, M. Almehmadi","doi":"10.4993/acrt.28.88","DOIUrl":"https://doi.org/10.4993/acrt.28.88","url":null,"abstract":"Background: Colorectal carcinoma is the second most common malignancy among Saudis. Cells derived from many hu- man malignant tissues have altered chromatin content and structure. The cellular Feulgen DNA content of malignant tissues is typically altered. Here we investigate the relationship between nuclear DNA content in colorectal carcinoma. Objectives: To demonstrate DNA in colorectal cancer cells using Feulgen reaction, and to determine the association between colon cancer grade and cellular DNA content. Design: Retrospective. Settings: Taif city- King Abdul Aziz specialized hospital. Patients and methods: Sections were stained with the Hematoxylin and Eosin method and the Feulgen reaction method for DNA demonstration. Sample size: Paraffin sections from 50 patients previously diagnosed with colon cancer were included in this study. Results: The histopathological diagnosis showed that 82% were adenocarcinoma cases, 18% had benign tumors. Regarding cancer grading, 56% of cases had moderately differentiated adenocarcinoma, 18% had low differentiated adenocarcinoma, 6% had high differentiated adenocarcinoma, and 2% had poorly differentiated adenocarcinoma. The staining intensity of the Feulgen reaction showed that 46% of tissue sections had intense staining, 22% had medium staining, and 14% had results comparable to control staining. We detected no significant associations between the cancer grade and age group, gender, or result of Feulgen reaction. Conclusion: DNA demonstration using the Feulgen reaction is a simple and successfully estimated in this study. However, the correlations between DNA staining and several clinicopathological factors were not statistically significant. We recommend that DNA staining should be combined with routine histopathological examination for better understanding of patients’ clinical malignant potential of the colorectal cancer.","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48532115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elmira Iriskulova, Tatiana Liudchyk, Ulugbek T. Kholtoev, A. Ganiev, A. Abdikhakimov, Salim K. Egamberdiev, Yulduz Khodjibekova, S. Mamarajabov, J. Sakamoto, M. Honda
Intraparotid facial nerve schwannoma (FNS) is very rare disease that is difficult to diagnose; thus, there is no established treatment strategy. We herein report two cases of intraparotid FNS and highlight the diagnostic and surgical approach. The first patient presented with painful parotid mass. We performed superficial parotidectomy as a diagnostic treatment. The continuity of the nerve was interrupted when we attempted to completely resect the tumor. After resection, we carried out reconstruction of the facial nerve using neurorrhaphy with end-to-end anastomosis. A histopathological examination revealed findings of intraparotid FNS. The House-Brackmann (HB) grade was II at a 2-year follow-up examination. No recurrence has been seen in the 2 years since surgery. The second patient presented with gradually progressive swelling in the right parotid region. The patient underwent tumor removal without parotidectomy via binocular magnification and a diode laser. As a result, the patient’s facial nerve function was intact at an 8-year follow-up examination (HB grade I). Tumor recurrence was not identified. Microsurgical and diode laser approaches in the management of intraparotid FNS resulted in a better overall facial nerve function without recurrence. Resection of intraparotid FNS with microsurgical and diode laser approaches should be included in a management algorithm, with prioritization of preservation of the facial nerve function.
{"title":"Intraparotid facial nerve schwannoma: A cross-country report of two cases and literature review","authors":"Elmira Iriskulova, Tatiana Liudchyk, Ulugbek T. Kholtoev, A. Ganiev, A. Abdikhakimov, Salim K. Egamberdiev, Yulduz Khodjibekova, S. Mamarajabov, J. Sakamoto, M. Honda","doi":"10.4993/acrt.28.93","DOIUrl":"https://doi.org/10.4993/acrt.28.93","url":null,"abstract":"Intraparotid facial nerve schwannoma (FNS) is very rare disease that is difficult to diagnose; thus, there is no established treatment strategy. We herein report two cases of intraparotid FNS and highlight the diagnostic and surgical approach. The first patient presented with painful parotid mass. We performed superficial parotidectomy as a diagnostic treatment. The continuity of the nerve was interrupted when we attempted to completely resect the tumor. After resection, we carried out reconstruction of the facial nerve using neurorrhaphy with end-to-end anastomosis. A histopathological examination revealed findings of intraparotid FNS. The House-Brackmann (HB) grade was II at a 2-year follow-up examination. No recurrence has been seen in the 2 years since surgery. The second patient presented with gradually progressive swelling in the right parotid region. The patient underwent tumor removal without parotidectomy via binocular magnification and a diode laser. As a result, the patient’s facial nerve function was intact at an 8-year follow-up examination (HB grade I). Tumor recurrence was not identified. Microsurgical and diode laser approaches in the management of intraparotid FNS resulted in a better overall facial nerve function without recurrence. Resection of intraparotid FNS with microsurgical and diode laser approaches should be included in a management algorithm, with prioritization of preservation of the facial nerve function.","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70577639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Ullah, Asad Ullah, A. Raziq, M. Lateef, N. Khan, Muhammad Waseem Khan
We reviewed different compounds derived from plants and their role in the treatment of various types of cancer cell lines. The herbal treatment has the least side effects as compared to the other treatments such as chemotherapy. Therefore, plant derivatives are considered as significant agent for treatment of cancer cells. As cancers are caused by the abnormal proliferation of cells, the extracted plant compounds induce apoptosis within the cancer cells through extrinsic or intrinsic pathway to inhibit the proliferation. Mitochondria have its major contribution in initiating apoptosis as it controls the level of cytochrome c. Many other regulatory proteins including p53 also support the inhibition of cell proliferation in cancer cell and induces fragmentation of DNA via apoptosis. Regulation of mitogen-activated protein (MAP) kinase and cleavage of poly (ADP-ribose) polymerase are the promoters and inhibitors of apoptosis. A cascade of caspases is also the functioning components of apoptosis induction and the expression of caspases control whether the pathway taken is intrinsic or extrinsic. Various compounds extracted from plants are discovered to be effective against the cancer cells.
{"title":"Role of Phytochemicals in Regulation of Cancer Cells: A Comprehensive Literature Review","authors":"H. Ullah, Asad Ullah, A. Raziq, M. Lateef, N. Khan, Muhammad Waseem Khan","doi":"10.4993/acrt.28.143","DOIUrl":"https://doi.org/10.4993/acrt.28.143","url":null,"abstract":"We reviewed different compounds derived from plants and their role in the treatment of various types of cancer cell lines. The herbal treatment has the least side effects as compared to the other treatments such as chemotherapy. Therefore, plant derivatives are considered as significant agent for treatment of cancer cells. As cancers are caused by the abnormal proliferation of cells, the extracted plant compounds induce apoptosis within the cancer cells through extrinsic or intrinsic pathway to inhibit the proliferation. Mitochondria have its major contribution in initiating apoptosis as it controls the level of cytochrome c. Many other regulatory proteins including p53 also support the inhibition of cell proliferation in cancer cell and induces fragmentation of DNA via apoptosis. Regulation of mitogen-activated protein (MAP) kinase and cleavage of poly (ADP-ribose) polymerase are the promoters and inhibitors of apoptosis. A cascade of caspases is also the functioning components of apoptosis induction and the expression of caspases control whether the pathway taken is intrinsic or extrinsic. Various compounds extracted from plants are discovered to be effective against the cancer cells.","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45496064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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