S. Mochida, Toshihisa Matsuzaki, K. Kawana, Kaoru Ohchi, R. Sakuma, M. Kurosaki
{"title":"Safety and effectiveness of glecaprevir/pibrentasvir in patients with chronic hepatitis C or compensated cirrhosis in daily clinical practice: a drug-use results survey","authors":"S. Mochida, Toshihisa Matsuzaki, K. Kawana, Kaoru Ohchi, R. Sakuma, M. Kurosaki","doi":"10.2957/kanzo.63.120","DOIUrl":"https://doi.org/10.2957/kanzo.63.120","url":null,"abstract":"","PeriodicalId":35810,"journal":{"name":"Acta Hepatologica Japonica","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41368196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Tajima, N. Fukushima, Keishi Kira, Masaaki Togo, Masashi Shibata, Shogo Mawatari, H. Hayashi, I. Shimokawa, F. Takeshima, K. Nakao
{"title":"A case of hepatitis C-related cirrhosis that developed cancer of unknown primary origin and followed with fulminant course after treatment with direct-acting antivirals","authors":"K. Tajima, N. Fukushima, Keishi Kira, Masaaki Togo, Masashi Shibata, Shogo Mawatari, H. Hayashi, I. Shimokawa, F. Takeshima, K. Nakao","doi":"10.2957/kanzo.63.77","DOIUrl":"https://doi.org/10.2957/kanzo.63.77","url":null,"abstract":"","PeriodicalId":35810,"journal":{"name":"Acta Hepatologica Japonica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46592892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Inoue, S. Kakizaki, H. Tojima, D. Todokoro, Koji Ogawa, T. Ikegami, Tomohisa Nishimura, H. Kunikata, M. Korenaga
{"title":"Questionnaire survey on hepatitis virus tests among ophthalmologists in Japan","authors":"J. Inoue, S. Kakizaki, H. Tojima, D. Todokoro, Koji Ogawa, T. Ikegami, Tomohisa Nishimura, H. Kunikata, M. Korenaga","doi":"10.2957/kanzo.63.87","DOIUrl":"https://doi.org/10.2957/kanzo.63.87","url":null,"abstract":"","PeriodicalId":35810,"journal":{"name":"Acta Hepatologica Japonica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43328955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Naomi Matsutani, Yuichirou Yokoyama, Shogo Shiratsuki, Shinya Kuwashiro, Kosuke Okita, T. Takami, I. Sakaida
{"title":"A case of bone marrow metastasis of hepatocellular carcinoma diagnosed by fluorodeoxyglucose-positron emission tomography","authors":"Naomi Matsutani, Yuichirou Yokoyama, Shogo Shiratsuki, Shinya Kuwashiro, Kosuke Okita, T. Takami, I. Sakaida","doi":"10.2957/kanzo.63.16","DOIUrl":"https://doi.org/10.2957/kanzo.63.16","url":null,"abstract":"","PeriodicalId":35810,"journal":{"name":"Acta Hepatologica Japonica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41544804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Liver cirrhosis is associated with impaired liver function due to various metabolic disorders, causing poor prognosis and several complications, such as hepatic encephalopathy. Although a number of studies have re-ported the favorable effects of branched-chain amino acid (BCAA) administration on hepatic encephalopathy, liver function, and prognosis, several studies have shown that BCAA administration might be associated with the following adverse effects: activated glutamine catabolism to ammonia and drainage of alpha-ketoglutarate from the TCA cycle. This review presents the mechanism and management of the favorable and harmful effects of BCAA administration in patients with liver cirrhosis.
{"title":"Favorable and harmful effects of branched-chain amino acid administration in patients with liver cirrhosis: effects on hepatic encephalopathy and ammonia metabolism","authors":"K. Katayama","doi":"10.2957/kanzo.63.1","DOIUrl":"https://doi.org/10.2957/kanzo.63.1","url":null,"abstract":"Liver cirrhosis is associated with impaired liver function due to various metabolic disorders, causing poor prognosis and several complications, such as hepatic encephalopathy. Although a number of studies have re-ported the favorable effects of branched-chain amino acid (BCAA) administration on hepatic encephalopathy, liver function, and prognosis, several studies have shown that BCAA administration might be associated with the following adverse effects: activated glutamine catabolism to ammonia and drainage of alpha-ketoglutarate from the TCA cycle. This review presents the mechanism and management of the favorable and harmful effects of BCAA administration in patients with liver cirrhosis.","PeriodicalId":35810,"journal":{"name":"Acta Hepatologica Japonica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43556789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yukiteru Yanabe, F. Ikeda, S. Fujioka, Hiromi Endo, Masayo Hirata, Kiyoko Akaki, Yoshimi Gondai, A. Arioka, Masami Hagane, Y. Kimura, Manri Kawakami, Toshiya Ohsawa
A health fair conducted by our hospital in 2019 provided participants the opportunity to undergo a hepatitis screening test and obtain the result on site. Of 70 participants who visited the fairʼs hepatitis test booth, 40 underwent the test on site, and 28 were aged ＜ 60 years. In 2018, a health fair informed participants of similar testing opportunities provided at our outpatient clinic at a later date; 15 people visited the clinic for the test, and 11 underwent the test. Eight (73%) tested individuals were aged ＞ 60 years. The ratio of test participants to fair visitors aged ＜ 60 years in 2019 (2.8%) was 18.7 times higher than those in 2018 (0.2%). Similarly, a threefold in-crease in the number of test participants was shown in those aged ＞ 60 years in 2019 compared with those in 2018. An on-site hepatitis virus screening test can be an efficient strategy for identifying middle-aged individuals with latent hepatitis.
{"title":"Effectiveness of hepatitis virus tests with on-site results in identifying middle-aged individuals with latent viral hepatitis","authors":"Yukiteru Yanabe, F. Ikeda, S. Fujioka, Hiromi Endo, Masayo Hirata, Kiyoko Akaki, Yoshimi Gondai, A. Arioka, Masami Hagane, Y. Kimura, Manri Kawakami, Toshiya Ohsawa","doi":"10.2957/kanzo.63.9","DOIUrl":"https://doi.org/10.2957/kanzo.63.9","url":null,"abstract":"A health fair conducted by our hospital in 2019 provided participants the opportunity to undergo a hepatitis screening test and obtain the result on site. Of 70 participants who visited the fairʼs hepatitis test booth, 40 underwent the test on site, and 28 were aged ＜ 60 years. In 2018, a health fair informed participants of similar testing opportunities provided at our outpatient clinic at a later date; 15 people visited the clinic for the test, and 11 underwent the test. Eight (73%) tested individuals were aged ＞ 60 years. The ratio of test participants to fair visitors aged ＜ 60 years in 2019 (2.8%) was 18.7 times higher than those in 2018 (0.2%). Similarly, a threefold in-crease in the number of test participants was shown in those aged ＞ 60 years in 2019 compared with those in 2018. An on-site hepatitis virus screening test can be an efficient strategy for identifying middle-aged individuals with latent hepatitis.","PeriodicalId":35810,"journal":{"name":"Acta Hepatologica Japonica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43765105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Masanari Kosaka, T. Kawaoka, Yusuke Johira, Yuki Shirane, Ryoichi Miura, Serami Murakami, Shigeki Yano, K. Amioka, Kensuke Naruto, Yuuwa Andou, Yumi Kosaka, Kenichiro Kodama, Sinsuke Uchikawa, H. Fujino, A. Oono, T. Nakahara, E. Murakami, M. Yamauchi, M. Imamura, S. Kuroda, Tsuyoshi Kobayashi, H. Ohdan, Yuko Nakamura, K. Awai, Aya Kido, K. Sentani, N. Oue, K. Arihiro, H. Aikata
{"title":"A patient with chronic hepatitis B who developed hepatocellular carcinoma with hypervascularity in 9 years of close follow-up","authors":"Masanari Kosaka, T. Kawaoka, Yusuke Johira, Yuki Shirane, Ryoichi Miura, Serami Murakami, Shigeki Yano, K. Amioka, Kensuke Naruto, Yuuwa Andou, Yumi Kosaka, Kenichiro Kodama, Sinsuke Uchikawa, H. Fujino, A. Oono, T. Nakahara, E. Murakami, M. Yamauchi, M. Imamura, S. Kuroda, Tsuyoshi Kobayashi, H. Ohdan, Yuko Nakamura, K. Awai, Aya Kido, K. Sentani, N. Oue, K. Arihiro, H. Aikata","doi":"10.2957/kanzo.63.24","DOIUrl":"https://doi.org/10.2957/kanzo.63.24","url":null,"abstract":"","PeriodicalId":35810,"journal":{"name":"Acta Hepatologica Japonica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49197329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Akuta, Y. Kawamura, Y. Arase, S. Saitoh, Nozomu Muraishi, Shunichiro Fujiyama, H. Sezaki, T. Hosaka, M. Kobayashi, M. Kobayashi, K. Ikeda, H. Kumada, F. Suzuki, Yoshiyuki Suzuki
A retrospective study based on serial liver biopsies was performed to investigate the efficacy of sodium-glucose cotransporter 2 inhibitor (SGLT2i) for non-alcoholic steatohepatitis (NASH) complicated by type 2 diabetes mellitus. Three cases were evaluated for liver histology at four points until 5 years after the start of treatment. All three cases showed a reworsening on physical examination. One case did not show histological change at the fourth biopsy compared to pretreat-ment, but the other two cases maintained histological improvement. All cases did not develop three-point ma-jor adverse cardiovascular events (MACE). In conclu-sion, long-term treatment of SGLT2i for NASH is asso-ciated with long-term improvement in liver histopa-thology. Further large-scale prospective studies are needed to determine the long-term impact for histological features and outcomes, including three-point MACE.
{"title":"Histological impact at 5 years after the start of sodium-glucose cotransporter 2 inhibitor for non-alcoholic steatohepatitis complicated by diabetes mellitus","authors":"N. Akuta, Y. Kawamura, Y. Arase, S. Saitoh, Nozomu Muraishi, Shunichiro Fujiyama, H. Sezaki, T. Hosaka, M. Kobayashi, M. Kobayashi, K. Ikeda, H. Kumada, F. Suzuki, Yoshiyuki Suzuki","doi":"10.2957/kanzo.62.820","DOIUrl":"https://doi.org/10.2957/kanzo.62.820","url":null,"abstract":"A retrospective study based on serial liver biopsies was performed to investigate the efficacy of sodium-glucose cotransporter 2 inhibitor (SGLT2i) for non-alcoholic steatohepatitis (NASH) complicated by type 2 diabetes mellitus. Three cases were evaluated for liver histology at four points until 5 years after the start of treatment. All three cases showed a reworsening on physical examination. One case did not show histological change at the fourth biopsy compared to pretreat-ment, but the other two cases maintained histological improvement. All cases did not develop three-point ma-jor adverse cardiovascular events (MACE). In conclu-sion, long-term treatment of SGLT2i for NASH is asso-ciated with long-term improvement in liver histopa-thology. Further large-scale prospective studies are needed to determine the long-term impact for histological features and outcomes, including three-point MACE.","PeriodicalId":35810,"journal":{"name":"Acta Hepatologica Japonica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48448158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yui Sasaki, S. Takaki, T. Fukuhara, Kazuki Ohya, Kei Morio, E. Miyaki, N. Mori, H. Okanobu, H. Ochi, H. Kakizawa, K. Tsuji, Y. Furukawa
{"title":"Portosystemic encephalopathy with hepatitis C cirrhosis after achieving SVR managed by percutaneous transhepatic shunt obliteration and portal systemic shunt disconnection","authors":"Yui Sasaki, S. Takaki, T. Fukuhara, Kazuki Ohya, Kei Morio, E. Miyaki, N. Mori, H. Okanobu, H. Ochi, H. Kakizawa, K. Tsuji, Y. Furukawa","doi":"10.2957/kanzo.62.813","DOIUrl":"https://doi.org/10.2957/kanzo.62.813","url":null,"abstract":"","PeriodicalId":35810,"journal":{"name":"Acta Hepatologica Japonica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42899319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hikaru Aoki, K. Yamanaka, Makoto Kurimoto, T. Matsuyama, Taku Iida, Masako Izuta, Hiroaki Tanaka, Tetsurou Yamamoto, M. Umeda
{"title":"Hepatic angiosarcoma with more extensive invasion than expected on imaging: A case report","authors":"Hikaru Aoki, K. Yamanaka, Makoto Kurimoto, T. Matsuyama, Taku Iida, Masako Izuta, Hiroaki Tanaka, Tetsurou Yamamoto, M. Umeda","doi":"10.2957/kanzo.62.793","DOIUrl":"https://doi.org/10.2957/kanzo.62.793","url":null,"abstract":"","PeriodicalId":35810,"journal":{"name":"Acta Hepatologica Japonica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41890048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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