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Maxillomandibular Advancement for OSA: A 25-year perspective 阻塞性睡眠呼吸暂停的上颌下颌进展:25年的观点
Q4 Medicine Pub Date : 2023-04-28 DOI: 10.1684/orthodfr.2023.114
Kasey Li, Jon-Erik Holey, Christian Guilleminault, Philippe Amat
ObjectiveThe aim of this study was to evaluate the result of maxillomandibular advancement (MMA) for the treatment of obstructive sleep apnea (OSA) by a single surgeon.Materials and MethodsPatients that underwent MMA for the treatment of OSA over a 25-year period were included in the study. Patients who initially presented for revision MMA surgery were excluded. Demographics (e.g., age, gender, pre- and post-MMA body mass index [BMI]), pre- and post-MMA cephalometrics (e.g., sella-nasion-point A angle [SNA], sella-nasion-point B angle [SNB], posterior airway space base of tongue [PAS]) and pre- and post-MMA sleep study metrics (e.g., respiratory disturbance index [RDI], lowest desaturation [SpO2-nadir], oxygen desaturation index [ODI], total sleep time [TST], % TST Stage N3 sleep, % TST rapid eye movement [REM] sleep) were abstracted. MMA surgical success was defined as a ≥ 50% reduction in RDI (or ODI) and post-MMA RDI (or ODI) < 20 events/hour. MMA surgical cure was defined as a post-MMA RDI (or ODI) < 5 events/hour.ResultsA total of 1010 patients underwent MMA for the treatment of OSA. The mean age was 39.6 ± 14.3 years, and the majority were male (77%). Nine hundred forty-one patients with complete pre- and postoperative PSG data were analyzed. The mean ODI and RDI improved from 32.6 ± 27.4 to 7.7 ± 15.5 and 39.1 ± 24.2 to 13.6 ± 14.6 events per hour, respectively. The overall surgical success and surgical cure based on ODI was 79.4% and 71.9%, respectively. The overall surgical success and surgical cure based on RDI was 73.1% and 20.7%, respectively. Stratified by preoperative RDI showed older age, greater BMI were associated with greater preoperative RDI. Bivariate predictors of greater RDI reduction include younger age, female gender, lower preoperative BMI, higher preoperative RDI, greater BMI reduction postoperatively and greater change in SNA and PAS. Bivariate predictors of surgical cure based on RDI (RDI < 5) include younger age, female gender, lower preoperative RDI, and greater change in SNA and PAS. Bivariate predictor of RDI success (RDI < 20) include younger age, female gender, lower preoperative BMI, lower preoperative RDI, greater BMI reduction, greater increase in SNA, SNB and PAS postoperatively. Comparison of the first 500 patients and the later 510 patients demonstrate patients undergoing MMA have become younger, having lower RDI while achieving a better surgical outcome. Linear multivariate associations of greater percentage RDI reduction include younger age, greater percent change of SNA, greater preoperative SNA, lower preoperative BMI and higher preoperative RDI.ConclusionsMMA is an effective treatment to improve OSA, but the result can vary. Patient selection based on favorable prognostic factors and maximizing the advancement distance can improve outcomes.
目的:本研究的目的是评估上颌下颚推进术(MMA)治疗阻塞性睡眠呼吸暂停(OSA)的效果。材料和方法:接受MMA治疗OSA超过25年的患者纳入研究。最初提出改良MMA手术的患者被排除在外。统计资料(如年龄、性别、mma前后的体重指数[BMI])、mma前后的头测量数据(如鞍鼻A点角度[SNA]、鞍鼻B点角度[SNB]、舌后气道空间基底[PAS])和mma前后的睡眠研究指标(如呼吸障碍指数[RDI]、最低去饱和度[SpO2-nadir]、氧去饱和指数[ODI]、总睡眠时间[TST]、TST N3期睡眠百分比、TST快速眼动[REM]睡眠百分比)均被提取出来。MMA手术成功定义为RDI(或ODI)降低≥50%,MMA后RDI(或ODI) < 20次/小时。MMA手术治愈定义为MMA后RDI(或ODI) < 5次/小时。结果:共有1010例患者接受了MMA治疗OSA。平均年龄39.6±14.3岁,男性居多(77%)。我们分析了941例患者完整的术前和术后PSG数据。平均ODI和RDI分别从32.6±27.4次/ h提高到7.7±15.5次/ h和39.1±24.2次/ h提高到13.6±14.6次/ h。总体手术成功率为79.4%,基于ODI的手术治愈率为71.9%。基于RDI的总体手术成功率和手术治愈率分别为73.1%和20.7%。术前RDI分层显示,年龄越大,BMI越大,术前RDI越大。RDI降幅较大的双变量预测因子包括:年龄较小、女性、术前BMI较低、术前RDI较高、术后BMI降幅较大、SNA和PAS变化较大。基于RDI (RDI < 5)的手术治愈的双变量预测因子包括年龄较小、女性、术前RDI较低、SNA和PAS变化较大。RDI成功(RDI < 20)的双因素预测因子包括:年龄较小、女性、术前BMI较低、术前RDI较低、BMI下降较大、术后SNA、SNB和PAS增加较大。前500例患者和后510例患者的比较表明,接受MMA的患者变得更年轻,RDI更低,手术效果更好。较大RDI百分比下降的线性多变量关联包括年龄较小、SNA变化百分比较大、术前SNA较大、术前BMI较低和术前RDI较高。结论:MMA是一种改善OSA的有效治疗方法,但效果不同。基于有利的预后因素和最大化进展距离的患者选择可以改善预后。
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引用次数: 0
Development of professional recommendations on orthodontic retention: short version 制定正畸固位的专业建议:简短版
Q4 Medicine Pub Date : 2023-04-28 DOI: 10.1684/orthodfr.2023.115
Alexandre Rolland, Olivier Sorel, Sarah Gebeile-Chauty

Introduction: Retention is the set of means, processes or devices that contribute to maintain the teeth in the position and the arches in the shape given by the treatment as long as possible. Given the heterogeneity of practices, devices used and follow-up modalities, the French Society of Dentofacial Orthopedics, a scientific society, has proposed Clinical Practice Guidelines (CPG) for orthodontic retention. This article presents the method used to develop the CPG full-text and the guidelines produced.

Materials and methods: A review of the literature was carried out after a bibliographic search of databases. The CPG full-text and guidelines were drafted, graded according to the level of evidence, then reread, discussed and validated by the experts of the workgroup. A second review by a group of external experts was then carried out before final validation of the CPG for publication.

Results: Of 652 articles selected, 53 met the inclusion criteria and were used to prepare the CPG full-text to produce 41 grade C items and 23 expert agreements, constituting 40 guidelines.

Discussion: There is still no consensus on the choice of materials. The literature remains poor on the functions. Some devices, more used in France, are poorly documented in the literature.

Conclusion: The CPGs provide recommendations on the factors to consider before using a retainer, the effectiveness of the different devices, their failures and adverse effects, as well as the follow-up procedures.

简介:固位是一套手段,过程或设备,有助于保持牙齿的位置和牙弓的形状,尽可能长时间的治疗。鉴于实践、使用的器械和随访方式的异质性,法国牙面矫形学会(一个科学学会)提出了正畸固位的临床实践指南(CPG)。本文介绍了开发CPG全文的方法和产生的指南。材料和方法:在数据库进行书目检索后,对文献进行综述。起草CPG全文和指南,根据证据水平进行分级,然后由工作组专家重新阅读、讨论和验证。在CPG最终确认出版之前,由一组外部专家进行了第二次审查。结果:入选的652篇文章中,53篇符合纳入标准,用于编制CPG全文,生成41个C级条目和23个专家协议,构成40条指南。讨论:在材料的选择上还没有达成共识。关于其功能的文献仍然很少。一些在法国更常用的器械在文献中记录得很少。结论:CPGs就使用固位器前需要考虑的因素、不同装置的有效性、失效和不良反应以及随访程序提供了建议。
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引用次数: 0
Atypical treatment plans and anchoring. What are the criteria for choosing anchorage for these complex treatments? 非典型治疗方案和锚定。对于这些复杂的治疗,选择支抗的标准是什么?
Q4 Medicine Pub Date : 2023-04-28 DOI: 10.1684/orthodfr.2023.110
Sophie Rozencweig, Georges Rozencweig

Introduction: In orthodontics, we need to solve very diverse clinical situations. Classical situations for which the treatment plan will be, with experience, quite quickly carried out. More complex clinical situations for which we are led to think differently. Sometimes, we must modify a treatment plan along the way because unforeseen factors make our original goals unattainable. Faced with these atypical situations, the choice of anchorage arises with even more acuity.

Methods: Through the presentation of two atypical treatment cases, we will discuss the development of the treatment plan, the alternatives, and the choice of anchorage.

Conclusion: In recent years, the advent of mini screws and other bone anchorages have widened the range of possibilities. If, at first glance, conventional anchorage systems might seem to belong to 20th century orthodontics, we believe that they remain an option to consider when establishing even atypical treatment plans, as much for their contribution on the functional and aesthetic level as on the level of the patient journey.

在正畸学中,我们需要解决非常多样化的临床情况。典型的情况下,根据经验,治疗计划将很快得到实施。更复杂的临床情况会让我们产生不同的想法。有时,我们必须修改治疗计划,因为不可预见的因素使我们最初的目标无法实现。面对这些非典型的情况,锚点的选择就更加尖锐了。方法:通过两个非典型治疗病例的介绍,我们将讨论治疗方案的发展,替代方案,以及锚定的选择。结论:近年来,微型螺钉和其他骨锚的出现拓宽了应用范围。如果,乍一看,传统的锚固系统似乎属于20世纪的正畸学,我们相信,当建立非典型的治疗计划时,它们仍然是一个可以考虑的选择,因为它们在功能和美学水平上的贡献与患者旅程的水平一样多。
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引用次数: 0
Maxillomandibular Advancement for OSA: Serious Complications and Failures 阻塞性睡眠呼吸暂停的上颌下颌进展:严重的并发症和失败
Q4 Medicine Pub Date : 2022-12-01 DOI: 10.1684/orthodfr.2022.88
Kasey Li, Christian Guilleminault

Objective: The focus of this report was to analyze patients who presented for second opinion due to complications and failure following maxillomandibular advancement (MMA) performed elsewhere.

Materials and methods: During a five-year period, 16 patients presented with complications and/ or failure of MMA. The indication for treatment was obstructive sleep apnea (OSA). Analysis of treatment records including plane radiography and/or cone beam computed tomography (CBCT), progress photographs and clinical examination were performed.

Results: Complete clinical and imaging records were available in all patients for analysis. Thirteen patients were surgical failures with advancement ranging from -4 to 5 mm. Five of the 13 patients had limited advancement at the initial surgery, and eight patients had hardware failure that required removal with resultant retrodisplacement of the mandible. Due to complications occurring in 11 patients, additional surgery ranging from two to six additional procedures after the initial operation was required. The complications included hardware failure (ten patients) that led to bone segment displacement (eight patients), non-union of the maxilla (two patients), non-union of the mandible (eight patients), chronic facial and/or joint pain (five patients), facial nerve injury (two patients), complete anesthesia of the lip/chin (five patients) and severe malocclusion (four patients).

Conclusions: Although MMA is typically a predictable operation with excellent outcomes, failure of improvement and severe long-term sequelae from surgical complications are possible. Surgical precision with sufficient skeletal advancement for airway improvement and stable skeletal fixation is necessary to achieve a successful outcome.

目的:本报告的重点是分析在其他地方进行上颌下颌前进手术(MMA)后因并发症和失败而提出第二意见的患者。材料和方法:在5年的时间里,16例患者出现MMA并发症和/或失败。治疗指征为阻塞性睡眠呼吸暂停(OSA)。对治疗记录进行分析,包括平面x线摄影和/或锥束计算机断层扫描(CBCT)、进展照片和临床检查。结果:所有患者均有完整的临床和影像学记录供分析。13例患者手术失败,进展从-4到5毫米不等。13例患者中有5例在初始手术时进展有限,8例患者有硬体故障,需要移除并导致下颌骨后移位。由于11例患者出现并发症,在初次手术后需要进行2至6次额外手术。并发症包括硬件故障(10例)导致骨段移位(8例),上颌骨不连(2例),下颌骨不连(8例),慢性面部和/或关节疼痛(5例),面神经损伤(2例),唇/下巴完全麻醉(5例)和严重错颌(4例)。结论:虽然MMA是一种典型的可预测的手术,预后良好,但手术并发症的改善失败和严重的长期后遗症是可能的。手术精度与足够的骨骼推进气道改善和稳定的骨骼固定是取得成功的必要条件。
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引用次数: 0
Third molars in the orthodontic therapeutic decision 第三磨牙在正畸治疗中的决定
Q4 Medicine Pub Date : 2022-12-01 DOI: 10.1684/orthodfr.2022.105
Alexandre Hutin, Sarah Gebeile-Chauty

Introduction: Despite a high prevalence of agenesis, third molars should frequently be considered in our orthodontic treatment plans.

Material and method: The aim of this study was to describe, according to the literature, the therapeutic possibilities of third molar management.

Results: The avulsion isn't systematic. The French National Authority for Health has updated its guidance about it. Indeed, surgical procedures can present with potentially irreversible risks (nerve damage, bone necrosis). It is necessary to assess the benefit/risk balance and to inform the patient accordingly. Whether symptomatic or not, pathological third molars are among the most obvious indication for avulsion as well as third molars that may lead to resorption or carious lesion of the adjacent molar. On the other hand, it is not recommended to avulse third molars to prevent the appearance of anterior crowding or in case of a favorable evolution. Some of our orthodontic therapies can lead to the avulsion of the third molars: the orthognathic surgery (especially mandibular surgery) or the distalization. They can be placed by transplantation, by mesialization, sometimes with the help of bone anchors, or by straightening the axis for a prosthetic or implant-prosthetic restoration.

Discussion: In the adolescent, the germs of the third molars would not limit the amount of distalization; these molars would continue to grow despite the distalization of the more anterior molars.

Conclusion: Wisdom teeth should be considered as third molars in their own right and can thus be used in edentulous situations.

尽管第三磨牙发育不全的发生率很高,但在我们的正畸治疗计划中应经常考虑第三磨牙。材料和方法:本研究的目的是描述,根据文献,第三磨牙管理的治疗可能性。结果:撕脱不具有系统性。法国国家卫生当局已经更新了关于它的指导意见。事实上,外科手术可能带来不可逆转的潜在风险(神经损伤、骨坏死)。有必要评估收益/风险平衡,并相应地告知患者。无论是否有症状,病理性第三磨牙是撕脱最明显的指征之一,第三磨牙可能导致相邻磨牙的吸收或龋齿病变。另一方面,不建议拔除第三磨牙,以防止出现前牙拥挤或在有利的进化情况下。我们的一些正畸治疗可能导致第三磨牙的撕脱:正颌手术(特别是下颌手术)或远端化。它们可以通过移植、中间化、有时借助骨锚或通过矫直轴进行假体或种植体-假体修复来放置。讨论:在青少年中,第三磨牙的细菌不会限制远端的数量;这些磨牙会继续生长,尽管更前的磨牙远端化。结论:智齿可作为第三磨牙,在无牙的情况下使用。
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引用次数: 0
Relevance of teleorthodontic tools: a systematic review of the literature 远端正畸工具的相关性:文献的系统回顾
Q4 Medicine Pub Date : 2022-12-01 DOI: 10.1684/orthodfr.2022.104
Fiona Rouanet, Caterina Masucci, Brandon Khorn, Arlette Oueiss, Sophie-Myriam Dridi, Carole Charavet

Introduction: The concept of teleorthodontics was recently born; the Covid-19 crise has participated to the emergence and the amplification of this phenomenon.

Objective: The main aim of the present systematic review was to evaluate the teleorthodontics relevance.

Method: An electronic and manual search was performed in four databases (PubMed, Scopus, Embase and Cochrane Library) up to December 2021 according to PRISMA guidelines. Both prospective and retrospective studies, as well as case reports, case series and satisfaction surveys published in English or in French without time restriction were included. Two independant reviewers were involved in the selection of the studies and a third reviewer was required in case of disagreement. A bias assessment was performed using the Mixed Methods Appraisal Tools.

Results: Out of 1757 articles, 22 articles published mainly between 2019 and 2021 and with varying levels of evidence, were included. Considering the results obtained, different concepts were discussed (time management, quality of communication, reliability and use of tools, satisfaction, quality of human relations, emergency management, compliance).

Conclusions: Teleorthodontics is an interesting and complementary tool that is, in no way, a systematic alternative to face-to-face orthodontic appointments in the office. However, many essential aspects of telemedicine in orthodontics, such as data protection, still need to be investigated in order to fully analyze this tool.

简介:远端正畸的概念是最近才诞生的;新冠肺炎疫情加剧了这一现象的出现和扩大。目的:本系统综述的主要目的是评价远端正畸的相关性。方法:根据PRISMA指南,在截至2021年12月的PubMed、Scopus、Embase和Cochrane Library四个数据库中进行电子和人工检索。前瞻性和回顾性研究、病例报告、病例系列和满意度调查均以英文或法文出版,没有时间限制。两名独立审稿人参与了研究的选择,如果有不同意见,需要第三名审稿人。使用混合方法评估工具进行偏倚评估。结果:在1757篇文献中,包括22篇主要发表于2019年至2021年之间且证据水平不同的文献。考虑到获得的结果,讨论了不同的概念(时间管理、通信质量、工具的可靠性和使用、满意度、人际关系质量、应急管理、合规性)。结论:远程正畸是一种有趣的辅助工具,在任何情况下,都不是在办公室面对面正畸预约的系统替代。然而,为了充分分析这一工具,远程医疗在正畸中的许多重要方面,如数据保护,仍需要进行调查。
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引用次数: 1
Obstructive sleep-disordered breathing and orthodontics. An interview with Christian Guilleminault, Michèle Hervy-Auboiron, Yu-Shu Huang and Kasey Li 阻塞性睡眠呼吸障碍与正畸。采访 Christian Guilleminault、Michèle Hervy-Auboiron、Yu-Shu Huang 和 Kasey Li
Q4 Medicine Pub Date : 2022-12-01 DOI: 10.1684/orthodfr.2022.96
Christian Guilleminault, Michèle Hervy-Auboiron, Yu-Shu Huang, Kasey Li, Philippe Amat
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引用次数: 0
Should Mandibular Symphyseal Distraction Osteogenesis be considered in OSA Surgery? 阻塞性睡眠呼吸暂停手术是否应考虑下颌联合牵张成骨?
Q4 Medicine Pub Date : 2022-12-01 DOI: 10.1684/orthodfr.2022.99
Kasey Li, Christian Guilleminault

Introduction: Surgical maxillary expansion for the treatment of obstructive sleep apnea (OSA) has become common place. To maximize airway improvement, over-expansion of the maxilla can occur, resulting in an excessively widened maxilla that creates a mismatch to the mandible. Therefore, mandibular symphyseal distraction osteogenesis (MSDO) to widen the mandible along with maxillary expansion is being increasingly advocated in OSA surgery.

Methods: The authors discuss their 20-year experience with MSDO and surgical maxillary expansion. They also analyze the airway impact between Distraction Osteogenesis Maxillary Expansion (DOME) and Endoscopically-Assisted Surgical Expansion (EASE) based on currently available computational fluid dynamic (CFD) data, which has implications in whether MSDO needs to be considered.

Results and conclusion: The goal of surgical maxillary expansion is to enlarge the nasal cavity and reduce the airway resistance. CFD data demonstrates that EASE results in a much greater reduction in airway resistance as compared to DOME. EASE achieved a 12-fold reduction in nasal airway resistance compared to 3-fold reduction by DOME; a 12-fold reduction of retropalatal airway resistance as compared to 3-fold reduction by DOME; a 10-fold reduction of oropharyngeal airway resistance as compared to a 3-fold reduction by DOME, and an 8-fold reduction of hypopharygeal airway resistance as compared to a 3-fold reduction by DOME. Because there is no physiologic basis or data that demonstrates mandibular widening improves OSA, an airway centric surgical expansion technique such as EASE can achieve a much greater airway impact without needing excessive maxillary widening, thus eliminating the necessity MSDO.

上颌扩张手术治疗阻塞性睡眠呼吸暂停(OSA)已成为常见的地方。为了最大限度地改善气道,可能会出现上颌骨过度扩张,导致上颌骨过度加宽,与下颌骨不匹配。因此,在OSA手术中,下颌联合牵张成骨术(下颌联合牵张成骨术)在上颌扩张的同时扩大下颌骨越来越受到推崇。方法:作者总结了20年的MSDO和上颌扩张手术的经验。他们还基于当前可用的计算流体动力学(CFD)数据分析了牵张成骨上颌扩张术(DOME)和内镜辅助手术扩张术(EASE)对气道的影响,这对是否需要考虑MSDO具有重要意义。结果与结论:上颌扩张术的目的是扩大鼻腔,减少气道阻力。CFD数据表明,与DOME相比,EASE可显著降低气道阻力。与DOME减少3倍相比,EASE减少了12倍的鼻气道阻力;与DOME减少3倍相比,腭后气道阻力减少12倍;口咽气道阻力比DOME减少3倍减少10倍,下咽气道阻力比DOME减少3倍减少8倍。由于没有生理学基础或数据表明下颌骨加宽改善OSA,因此以气道为中心的手术扩张技术,如EASE,可以在不需要过度上颌加宽的情况下实现更大的气道影响,从而消除了MSDO的必要性。
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引用次数: 0
Maxillomandibular Advancement for OSA: A 25-year perspective 阻塞性睡眠呼吸暂停的上颌下颌进展:25年的观点
Q4 Medicine Pub Date : 2022-12-01 DOI: 10.1684/orthodfr.2022.98
Kasey Li, Jon-Erik Holey, Christian Guilleminault

Objective: The aim of this study was to evaluate the result of maxillomandibular advancement (MMA) for the treatment of obstructive sleep apnea (OSA) by a single surgeon.

Materials and methods: Patients that underwent MMA for the treatment of OSA over a 25-year period were included in the study. Patients who initially presented for revision MMA surgery were excluded. Demographics (e.g., age, gender, pre- and post-MMA body mass index [BMI]), pre- and post-MMA cephalometrics (e.g., sella-nasion-point A angle [SNA], sella-nasion-point B angle [SNB], posterior airway space base of tongue [PAS]) and pre- and post-MMA sleep study metrics (e.g., respiratory disturbance index [RDI], lowest desaturation [SpO2-nadir], oxygen desaturation index [ODI], total sleep time [TST], % TST Stage N3 sleep, % TST rapid eye movement [REM] sleep) were abstracted. MMA surgical success was defined as a ≥ 50% reduction in RDI (or ODI) and post-MMA RDI (or ODI) < 20 events/hour. MMA surgical cure was defined as a post-MMA RDI (or ODI) < 5 events/hour.

Results: A total of 1010 patients underwent MMA for the treatment of OSA. The mean age was 39.6 ± 14.3 years, and the majority were male (77%). Nine hundred forty-one patients with complete pre- and postoperative PSG data were analyzed. The mean ODI and RDI improved from 32.6 ± 27.4 to 7.7 ± 15.5 and 39.1 ± 24.2 to 13.6 ± 14.6 events per hour, respectively. The overall surgical success and surgical cure based on ODI was 79.4% and 71.9%, respectively. The overall surgical success and surgical cure based on RDI was 73.1% and 20.7%, respectively. Stratified by preoperative RDI showed older age, greater BMI were associated with greater preoperative RDI. Bivariate predictors of greater RDI reduction include younger age, female gender, lower preoperative BMI, higher preoperative RDI, greater BMI reduction postoperatively and greater change in SNA and PAS. Bivariate predictors of surgical cure based on RDI (RDI < 5) include younger age, female gender, lower preoperative RDI, and greater change in SNA and PAS. Bivariate predictor of RDI success (RDI < 20) include younger age, female gender, lower preoperative BMI, lower preoperative RDI, greater BMI reduction, greater increase in SNA, SNB and PAS postoperatively. Comparison of the first 500 patients and the later 510 patients demonstrate patients undergoing MMA have become younger, having lower RDI while achieving a better surgical outcome. Linear multivariate associations of greater percentage RDI reduction include younger age, greater percent change of SNA, greater preoperative SNA, lower preoperative BMI and higher preoperative RDI.

Conclusions: MMA is an effective treatment to improve OSA, but the result can vary. Patient selection based on favorable prognostic factors and maximizing the advancement distance can improve outcomes.

目的:本研究的目的是评估上颌下颚推进术(MMA)治疗阻塞性睡眠呼吸暂停(OSA)的效果。材料和方法:接受MMA治疗OSA超过25年的患者纳入研究。最初提出改良MMA手术的患者被排除在外。统计资料(如年龄、性别、mma前后的体重指数[BMI])、mma前后的头测量数据(如鞍鼻A点角度[SNA]、鞍鼻B点角度[SNB]、舌后气道空间基底[PAS])和mma前后的睡眠研究指标(如呼吸障碍指数[RDI]、最低去饱和度[SpO2-nadir]、氧去饱和指数[ODI]、总睡眠时间[TST]、TST N3期睡眠百分比、TST快速眼动[REM]睡眠百分比)均被提取出来。MMA手术成功定义为RDI(或ODI)降低≥50%,MMA后RDI(或ODI) < 20次/小时。MMA手术治愈定义为MMA后RDI(或ODI) < 5次/小时。结果:共有1010例患者接受了MMA治疗OSA。平均年龄39.6±14.3岁,男性居多(77%)。我们分析了941例患者完整的术前和术后PSG数据。平均ODI和RDI分别从32.6±27.4次/ h提高到7.7±15.5次/ h和39.1±24.2次/ h提高到13.6±14.6次/ h。总体手术成功率为79.4%,基于ODI的手术治愈率为71.9%。基于RDI的总体手术成功率和手术治愈率分别为73.1%和20.7%。术前RDI分层显示,年龄越大,BMI越大,术前RDI越大。RDI降幅较大的双变量预测因子包括:年龄较小、女性、术前BMI较低、术前RDI较高、术后BMI降幅较大、SNA和PAS变化较大。基于RDI (RDI < 5)的手术治愈的双变量预测因子包括年龄较小、女性、术前RDI较低、SNA和PAS变化较大。RDI成功(RDI < 20)的双因素预测因子包括:年龄较小、女性、术前BMI较低、术前RDI较低、BMI下降较大、术后SNA、SNB和PAS增加较大。前500例患者和后510例患者的比较表明,接受MMA的患者变得更年轻,RDI更低,手术效果更好。较大RDI百分比下降的线性多变量关联包括年龄较小、SNA变化百分比较大、术前SNA较大、术前BMI较低和术前RDI较高。结论:MMA是一种改善OSA的有效治疗方法,但效果不同。基于有利的预后因素和最大化进展距离的患者选择可以改善预后。
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引用次数: 1
Nasomaxillary Expansion by Endoscopically-Assisted Surgical Expansion (EASE): An airway centric approach 内镜辅助下的鼻上颌扩张手术(EASE):一种以气道为中心的方法
Q4 Medicine Pub Date : 2022-12-01 DOI: 10.1684/orthodfr.2022.97
Kasey Li, Tomonori Iwasaki, Stacey Quo, Eileen B Leary, Connor Li, Christian Guilleminault

Introduction: The aim of this study was to analyze the skeletal, dental and airway changes with endoscopically assisted surgical expansion (EASE) to widen the nasomaxillary complex for the treatment of sleep apnea in adults.

Methods: One hundred and five consecutive patients underwent EASE. Cone beam computed tomography (CBCT) was conducted preoperatively and within four weeks after the completion of the expansion process. Computational fluid dynamic (CFD) analysis was performed on 20 randomly selected patients to assess airway flow changes.

Results: One hundred patients (67 males) with the mean age of 35.0±13.5 years (17-64 years) had completed pre- and post-expansion imaging. Ninety-six patients (96%) had successful expansion defined as separation of the midpalatal suture at least 1 mm from anterior nasal spine (ANS) to posterior nasal spine (PNS). The nasal cavity expansion was 3.12±1.11 mm at ANS, 3.64±1.06 mm at first molar and 2.39±1.15 mm at PNS. The zygoma expansion was 2.17±1.11 mm. The ratio of dental expansion to skeletal expansion was 1.23:1 (3.83 mm:3.12 mm) at canine and 1.31:1 (4.77 mm:3.64 mm) at first molar. CFD airway simulation showed a dynamic change following expansion throughout the airway. The mean negative pressure improved in the nasal airway (from -395.5±721.0 to -32.7±19.2 Pa), nasopharyngal airway (from -394.2±719.4 to -33.6±18.5 Pa), oropharyngeal airway (from -405.9±710.8 to -39.4±19.3 Pa) and hypopharyngeal airway (from -422.6±704.9 to -55.1±33.7 Pa). The mean airflow velocity within the nasal airway decreased from 18.8±15.9 to 7.6±2.0 m/s and the oropharyngeal airway decreased from 4.2±2.9 to 3.2±1.2 m/s. The velocity did not change significantly in the nasopharyngeal and hypopharyngeal regions.

Conclusions: EASE results in expansion of the midpalatal suture from the ANS to PNS with a nearly pure skeletal movement of minimal dental effect. The expansion of the nasomaxillary complex resulted in the widening of the nasal sidewall throughout the nasal cavity. The improved air flow dynamics was demonstrated by CFD simulation.

本研究的目的是分析内镜辅助手术扩张术(EASE)对成人睡眠呼吸暂停患者的骨骼、牙齿和气道的改变。方法:连续105例患者行EASE。锥形束计算机断层扫描(CBCT)在术前和扩张过程完成后四周内进行。随机选取20例患者进行计算流体动力学(CFD)分析,评估气道流量变化。结果:100例患者(男性67例),平均年龄35.0±13.5岁(17-64岁),完成扩张前后显像。96例(96%)患者成功扩展,定义为中腭缝合线从鼻前棘(ANS)到鼻后棘(PNS)至少分离1mm。初磨牙的鼻腔扩张为3.12±1.11 mm,初磨牙为3.64±1.06 mm,初磨牙为2.39±1.15 mm。颧骨扩张2.17±1.11 mm。牙扩展与骨骼扩展的比例为:犬齿为1.23:1 (3.83 mm:3.12 mm),第一磨牙为1.31:1 (4.77 mm:3.64 mm)。CFD气道模拟显示了气道扩张后的动态变化。鼻气道(从-395.5±721.0到-32.7±19.2 Pa)、鼻咽气道(从-394.2±719.4到-33.6±18.5 Pa)、口咽气道(从-405.9±710.8到-39.4±19.3 Pa)和下咽气道(从-422.6±704.9到-55.1±33.7 Pa)的平均负压均有所改善。鼻道内平均气流速度由18.8±15.9下降至7.6±2.0 m/s,口咽道平均气流速度由4.2±2.9下降至3.2±1.2 m/s。鼻咽部和下咽区的流速变化不明显。结论:EASE可以将中腭缝线从上牙区扩展到上牙区,几乎是纯粹的骨骼运动,对牙齿的影响最小。鼻上颌复合体的扩张导致整个鼻腔的鼻侧壁变宽。通过CFD仿真验证了改进后的空气动力学特性。
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L'' Orthodontie française
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