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Prevalence and predictive determinants of overweight and obesity in children aged 0-24 months in Morocco: a cross-sectional study. 摩洛哥 0-24 个月儿童超重和肥胖的流行率和预测性决定因素:一项横断面研究。
Q2 Medicine Pub Date : 2023-01-01 DOI: 10.32394/rpzh.2023.0285
Fatima Zohra Benayad, Samia El Hilali, Rachid Razine, Karim Sbai Idrissi, Redouane Abouqal, Hajar Belhaj, Ahmed Kharbach, Majdouline Obtel

Background: Preventing overweight and obesity in early childhood is a priority for healthcare systems worldwide due to the harmful effects on health and economy over the medium and long term.

Objective: The aim of this study is therefore the identification of the determinants predictive of overweight and obesity during the first 24 months of a child's life.

Material and methods: From May 2021 to January 2022, 1012 mother-child pairs were included in this study and were interviewed at urban and rural health centers in the Skhirat-Temara in Morocco prefecture using a questionnaire. The anthropometric measurements of the children were also taken according to World Health Organization standards.

Results: The prevalence of overweight and obesity in children aged 0-24 months was 16.5%. This prevalence increased with age (12.5% for the 0-6 months group, and 15.5% and 21.5% respectively for the 7-12 months and 13-24 months groups). Cesarean delivery (aOR=1.78; 95%CI: 1.26-2.51; p=0.001), more than two living siblings in the household (aOR=1.48; 95%CI: 1.03-2.12; p=0.03), male gender (aOR=1.56; 95%CI: 1.10-2.20; p=0.01), and child age (aOR=0.94; 95%: 0.92-0.97; p <0.001) are significant predictors of overweight and obesity. Paternal smoking (aOR=2.16; 95%CI: 1.15- 4.06; p=0.01), short sleep duration (aOR=4.05; 95%CI: 1.27-12.88; p=0.01) in children aged 7-12 months, and combined breastfeeding (aOR=5.88; 95%CI: 2.07-16.72; p<0.001) during the first six months in children aged 13-24 months are also predictive determinants for this problem.

Conclusion: The identification of early predictors of overweight and obesity can be used by public health decision-makers as a roadmap for action to prevent and improve health.

背景:预防儿童早期超重和肥胖是全球医疗保健系统的当务之急,因为从中长期来看,超重和肥胖会对健康和经济产生有害影响:因此,本研究旨在确定儿童出生后 24 个月内预测超重和肥胖的决定因素:2021 年 5 月至 2022 年 1 月,本研究共纳入 1012 对母子,在摩洛哥斯基拉特-特马拉省的城市和农村医疗中心进行了问卷调查。此外,还根据世界卫生组织的标准对儿童进行了人体测量:结果:0-24 个月儿童的超重和肥胖率为 16.5%。随着年龄的增长,超重和肥胖的发生率也在增加(0-6 个月组为 12.5%,7-12 个月组和 13-24 个月组分别为 15.5%和 21.5%)。剖腹产(aOR=1.78;95%CI:1.26-2.51;p=0.001)、家中有两个以上在世的兄弟姐妹(aOR=1.48;95%CI:1.03-2.12;p=0.03)、男性(aOR=1.56;95%CI:1.10-2.20;p=0.01)和儿童年龄(aOR=0.94;95%CI:0.92-0.97;p=0.01):0.92-0.97; p 结论:公共卫生决策者可将确定超重和肥胖的早期预测因素作为采取行动预防和改善健康的路线图。
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引用次数: 0
Radon - occurrence and impact on the health. 氡的发生及其对健康的影响。
Q2 Medicine Pub Date : 2023-01-01 DOI: 10.32394/rpzh.2023.0242
Małgorzata M Dobrzyńska, Aneta Gajowik, Kamil Wieprzowski

Radon is noble, monatomic, radioactive, heavier than the air gas. It is colorless, odorless, tasteless. It exists in natural environment as a result of the decay of radium, and emits mainly alpha radiation and less beta radiation. Residential radon concentrations vary widely by geographic area. The higher concentration of radon is expected globally in the grounds where uranium, radium and thoron are present. Radon may gather in caves, tunnels, mines as well as in other lowestlying spaces, such as basements, and cellars. In accordance with Atomic Law (2000), the reference level for the average annual concentration of radioactive radon in rooms intended for human habitation is 300 Bq/m3. The most dangerous damages caused by ionizing radiation i.e. radon and its derivatives are changes to DNA, which may disturb the functions of cells and in the consequence lead to induction of cancer of respiratory tract, mainly of lungs and also leukaemia. So, the main consequence of exposure to high amount of radon are cancers of respiratory system. Radon enters the human organism mainly through inhaled atmospheric air. Moreover, radon significantly increased a risk of induction cancer in smokers and vice versa, smoking promotes the development of lung cancer after the exposure to radon and its derivatives. Radon may also have beneficial effect on the human body. Therefore it is used in medicine; mainly in radonbalneotherapy i.e. bath treatments, rinsing the mouth and inhalation. Beneficial effects of radon confirms the validity of the theory of radiation hormesis, which assumes that low doses of radiation may stimulate the repair of DNA damage by activation of protective mechanisms, which neutralize free radicals.

氡是稀有的、单原子的、放射性的,比空气中的气体重。它无色、无臭、无味。它由于镭的衰变而存在于自然环境中,主要发射α辐射,较少发射β辐射。住宅氡浓度因地理区域而异。在全球范围内,在存在铀、镭和钍的地方,氡的浓度预计会更高。氡可能聚集在洞穴、隧道、矿井以及其他较低的空间,如地下室和地窖。根据《原子法》(2000年),供人类居住的房间中放射性氡的年平均浓度的参考水平为300 Bq/m3。电离辐射(即氡及其衍生物)造成的最危险的损害是DNA的变化,这可能扰乱细胞的功能,从而导致诱发呼吸道癌症,主要是肺癌和白血病。因此,暴露于大量氡的主要后果是呼吸系统癌症。氡主要通过吸入大气进入人体。此外,氡显著增加了吸烟者诱发癌的风险,反之亦然,吸烟在暴露于氡及其衍生物后促进肺癌的发展。氡也可能对人体有益。因此,它被用于医学;主要是氡疗法,即沐浴治疗、漱口和吸入。氡的有益作用证实了辐射激效理论的有效性,该理论认为,低剂量的辐射可以通过激活中和自由基的保护机制来刺激DNA损伤的修复。
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引用次数: 1
Health workers' capability, opportunity, motivation, and behavior to prevent and control COVID-19 in a high-risk district in Thailand. 泰国某高危地区卫生工作者防控COVID-19的能力、机会、动机和行为
Q2 Medicine Pub Date : 2023-01-01 DOI: 10.32394/rpzh.2023.0245
Suttida Sangpoom, Femi Adesina, Joenathan Saetang, Nittaya Thammachot, Kawintida Jeenmuang, Charuai Suwanbamrung

Background: Village health volunteers have been an important group who plays the role in prevention and control of COVID-19 pandemic situations at primary care units, Thailand.

Objective: The objective of this cross-sectional analytic study was to assess the level and analyze the association between personal information, capability, opportunities, motivations, and behaviors to prevent and control COVID-19 among Village healthy volunteers in a high risk district, Southern Thailand.

Material and methods: G*power program was used to calculate the sample size of 145 VHVs recruited for this study. Data collection was done using a well-structured questionnaire with 5-point Likert scale for capability, opportunities, motivations, and behaviors component, and multi-stage sampling of 18 sub-district health promoting hospitals was carried out. Data analysis was done using descriptive, Chi-square and Fisher Exact test.

Results: Majority (89.7%) of the VHVs were female, and 62.8% were 28-59 years old. More than half, 55.9% (81) have been VHVs for 11-36 years. Generally, higher capacity was found among 59.3% (86) of the VHVs, low opportunity level among 81.4% (118), high motivation among 53.8% (78) and a good behavior towards the prevention and control of COVID-19 among 72.4% (105). The VHVs' age and duration of practicing were significantly (P< 0.01 and P < 0.05 respectively) associated with COVID-19 prevention behavior (x2 =6.894 and 5.255 respectively). Likewise, there are significant association between capacity (p ≤ 0.001 and x2 = 31.014), opportunity (p≤ 0.05 and x2 = 9.473), motivation (p ≤ 0.001 and x2 = 0.0001) and VHVs' behaviour to prevent and control COVID-19.

Conclusion: HVHs' opportunity is very low in the study area and it negatively affects good behavior for the prevention and control of COVID-19. All stakeholders in the district can use the association among the capability, opportunity, motivation and behavioral model to develop practice guideline and set policy for preventing COVID-19 in the community.

背景:在泰国初级保健单位,乡村卫生志愿者是预防和控制COVID-19大流行疫情的重要群体。目的:本横断面分析研究的目的是评估泰国南部一个高风险地区乡村健康志愿者预防和控制COVID-19的个人信息、能力、机会、动机和行为的水平并分析两者之间的关联。材料和方法:使用G*power程序计算本研究招募的145台vhv的样本量。采用结构合理的李克特5分制问卷,对18家街道健康促进医院的能力、机会、动机和行为成分进行多阶段抽样。数据分析采用描述性检验、卡方检验和Fisher精确检验。结果:女性占绝大多数(89.7%),其中28 ~ 59岁占62.8%。超过一半(55.9%,81人)是11-36年的vhv。总体而言,有较高能力的有59.3%(86人),有低机会的有81.4%(118人),有较高积极性的有53.8%(78人),有良好防控行为的有72.4%(105人)。VHVs年龄、执业时间与预防行为有显著相关性(分别为P< 0.01、P< 0.05) (x2 =6.894、5.255)。同样,vhv预防和控制COVID-19的能力(p≤0.001,x2 = 31.014)、机会(p≤0.05,x2 = 9.473)、动机(p≤0.001,x2 = 0.0001)与vhv行为之间存在显著关联。结论:研究区HVHs发生几率极低,对预防和控制COVID-19的良好行为产生负面影响。地区的所有利益相关者都可以利用能力、机会、动机和行为模式之间的关联来制定社区预防COVID-19的实践指南和政策。
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引用次数: 1
Validity, reliability and prevalence estimates of nomophobia among undergraduate dental students of Bhubaneswar, India. 印度布巴内斯瓦尔大学牙科学生nomophobia的效度、信度和患病率估计。
Q2 Medicine Pub Date : 2023-01-01 DOI: 10.32394/rpzh.2023.0246
Upasana Mohapatra, Ramesh Nagarajappa, Dharmashree Satyarup, Sailaja Panda

Background: Considered a modern phobia, Nomophobia (NO MObile PHOne PhoBIA) is a term describing irrational fear or anxiety of being unable to access one's own mobile phone.

Objectives: To develop and validate the nomophobia questionnaire, administering it to a sample of adolescents representing undergraduate dental students. To assess the prevalence of Nomophobia, determine the usage pattern of mobile phones and evaluate the impact due to lack of access to mobile phones among undergraduate dental students.

Material and method: A cross-sectional study was conducted on 302 undergraduate students of Bhubaneswar through a self-administered questionnaire via Google Forms consisting of 19 items evaluating the pattern and anxiety related to usage of mobile phones. Responses were recorded on a 5-point Likert scale. Kruskal Wallis, Mann-Whitney U and Chisquare tests were used for statistical analysis.

Results: Test-Retest reliability showed kappa of k=0.86 and Internal consistency Chronbach's-Alpha to be α=0.82. Prevalence of nomophobia (score ≥ 58) was 32.1%, and students at risk of being nomophobic (score 39-57) was 61.9%. It was highest in males (32.6%) and amongst the interns (41.9%) and lowest (25.5%) amongst the second-year students. Participants felt nervous/insecure if their phones were away from them because of the fear that somebody might have accessed their data (3.07±1.93) and or tried to contact them (3.09±1.13) which were not statistically significant (p>0.05).

Conclusions: The present study confirms that nomophobia is an emerging behavioural addiction among dental students. Adequate prevention strategies would be helpful in reducing the impact of the chronic mobile usage. Effect of the mobile phone on dental students and the fear of not having it with them is increasing elaborately, that needs to be controlled. Otherwise, it would negatively affect their academic achievement and well-being.

背景:Nomophobia(无手机恐惧症)被认为是一种现代恐惧症,是一个描述无法使用自己手机的非理性恐惧或焦虑的术语。目的:开发和验证无手机恐惧症问卷,并对代表牙科本科学生的青少年样本进行管理。评估无手机恐惧症的患病率,确定手机的使用模式,并评估因缺乏手机而对牙科本科学生的影响。材料和方法:对302名布巴内斯瓦尔的本科生进行了一项横断面研究,通过谷歌表格进行了一份由19个项目组成的自我管理问卷,评估了与手机使用相关的模式和焦虑。回答以5分李克特量表记录。采用Kruskal Wallis、Mann-Whitney U和Chisquare检验进行统计分析。结果:重测信度kappa为k=0.86,内部一致性Chronbach’s- alpha为α=0.82。无手机恐惧症患病率(得分≥58)为32.1%,有患无手机恐惧症风险的学生(得分39-57)为61.9%。男性(32.6%)和实习生(41.9%)的比例最高,二年级学生的比例最低(25.5%)。由于担心有人可能访问他们的数据(3.07±1.93)或试图联系他们(3.09±1.13),如果他们的手机远离他们,参与者会感到紧张/不安全(p>0.05)。结论:本研究证实,无牌恐惧症是一种新兴的牙科学生的行为成瘾。适当的预防策略将有助于减少长期使用手机的影响。手机对牙科学生的影响和对没有手机的恐惧正在增加,这需要控制。否则,会对他们的学业成绩和幸福感产生负面影响。
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引用次数: 0
Folic acid - importance for human health and its role in COVID-19 therapy. 叶酸对人体健康的重要性及其在COVID-19治疗中的作用
Q2 Medicine Pub Date : 2023-01-01 DOI: 10.32394/rpzh.2023.0252
Katarzyna Kurowska, Milena Kobylińska, Katarzyna Antosik

Folic acid (folacin, B9) is a vitamin that performs many very important functions in the human body, and its inadequate level - deficiency as well as excess, may contribute to an increased risk of developing many disease processes. The aim of this study was to analyze the available scientific literature on folic acid and its impact on human health. A systematic review of the studies, published until November 2022, was made on the basis of searching bibliographic databases such as: PubMed, Elsevier and Google Scholar. The following keywords and combinations were used: folic acid, folate, folic acid supplementation, folate deficiency. Folic acid, thanks to its high biological activity, has a direct and indirect effect on the metabolism of the human body cells. It plays a very important role, among others in the prevention of neural tube defects and megaloblastic anemia, the proper functioning of the nervous system, as well as reducing the risk of developing certain cancers. Currently, the important role of folic acid in maintaining the proper functioning of the immune system is also emphasized, which is of particular importance both in the prevention and in the situation of SARS-CoV-2 (COVID-19) infection. The effects of deficiency and excess of vitamin B9 may turn out to be dangerous to health and even life. There is a need for nutritional and health education of the society regarding the importance of folic acid for human health, due to the presence of large deficiencies in the population, which is particularly important for some social groups, such as, for example, women of procreation age, pregnant or breastfeeding, people with a nutrient malabsorption, and people who smoke or abuse alcohol.

叶酸(Folic acid, B9)是一种维生素,在人体中发挥着许多非常重要的功能,它的不足——缺乏和过量——可能会增加患许多疾病的风险。本研究的目的是分析现有的关于叶酸及其对人体健康影响的科学文献。在检索PubMed、Elsevier和Google Scholar等书目数据库的基础上,对这些发表到2022年11月的研究进行了系统回顾。采用以下关键词和组合:叶酸、叶酸盐、叶酸补充、叶酸缺乏。叶酸由于其较高的生物活性,对人体细胞的代谢有直接和间接的影响。它在预防神经管缺陷和巨幼细胞性贫血、神经系统正常运作以及降低患某些癌症的风险等方面发挥着非常重要的作用。目前,叶酸在维持免疫系统正常功能方面的重要作用也被强调,这在预防和COVID-19感染的情况下都具有特别重要的意义。维生素B9缺乏和过量的影响可能会对健康甚至生命造成危害。有必要就叶酸对人体健康的重要性对社会进行营养和健康教育,因为人口中存在大量缺乏叶酸的情况,这对某些社会群体尤其重要,例如育龄妇女、孕妇或哺乳期妇女、营养吸收不良的人以及吸烟或酗酒的人。
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引用次数: 1
Sociodemographic, nutritional and health status factors associated with adherence to Mediterranean diet in an agricultural Moroccan adult's population. 与摩洛哥农业成年人坚持地中海饮食有关的社会人口、营养和健康状况因素。
Q2 Medicine Pub Date : 2023-01-01 DOI: 10.32394/rpzh.2023.0256
Rachida Moustakim, Mohamed Mziwira, Mohammed El-Ayachi, Rekia Belahsen
BackgroundNumerous studies have demonstrated beneficial effects of adherence to the Mediterranean diet (MD) on many chronic diseases, including chronic kidney disease (CKD).ObjectiveThe aim of this study was to assess the adherence of a rural population to the Mediterranean diet, to identify the sociodemographic and lifestyle determinants and to analyze the association between adherence to MD and CKD.Material and MethodsIn a cross-sectional study, data on sociodemographic, lifestyle factors, clinical, biochemical parameters and diet were collected on a sample of 154 subjects. Adherence to MD was assessed according to a simplified MD score based on the daily frequency of intake of eight food groups (vegetables, legumes, fruits, cereal or potatoes, fish, red meat, dairy products and MUFA/SFA), using the sex specific sample medians as cut-offs. A value of 0 or 1 was assigned to consumption of each component according to its presumed detrimental or beneficial effect on health.ResultsAccording to the simplified MD score, the study data show that high adherence (44.2%) to MD was characterized by intakes high in vegetables, fruits, fish, cereals, olive oil, and low in meat and moderate in dairy. Furthermore, several factors such as age, marital status, education level, and hypertension status were associated with the adherence to MD in the study population. The majority of subjects with CKD have poor adherence to the MD compared to non-CKD with a statistically insignificant difference.ConclusionsIn Morocco, maintaining the traditional MD pattern play crucial role for public health. More research is needed in this area to precisely measure this association.
背景:大量研究表明,坚持地中海饮食(MD)对许多慢性疾病,包括慢性肾病(CKD)有益。目的:本研究的目的是评估农村人口对地中海饮食的依从性,确定社会人口统计学和生活方式的决定因素,并分析坚持MD和CKD之间的关系。材料与方法:采用横断面研究方法,收集154名研究对象的社会人口学、生活方式因素、临床、生化参数和饮食数据。根据基于八种食物组(蔬菜、豆类、水果、谷物或土豆、鱼、红肉、乳制品和MUFA/SFA)每日摄入频率的简化MD评分,使用特定性别的样本中位数作为截断值,对MD依从性进行评估。根据每种成分对健康的假定有害或有益影响,将其消耗量定为0或1。结果:根据简化的MD评分,研究数据显示,高MD依从性(44.2%)的特征是摄入量高的蔬菜、水果、鱼类、谷物、橄榄油,低的肉类和适度的乳制品。此外,年龄、婚姻状况、教育水平和高血压状况等因素与研究人群的MD依从性有关。与非CKD患者相比,大多数CKD患者对MD的依从性较差,差异无统计学意义。结论:在摩洛哥,维持传统的MD模式对公共卫生至关重要。在这一领域需要更多的研究来精确测量这种关联。
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引用次数: 0
Factors related to alcohol-drinking behaviors on secondary school students grade 1-3 in the province of Nakhon Si Thammarat Thailand. 泰国那空四塔玛拉府 1-3 年级中学生饮酒行为的相关因素。
Q2 Medicine Pub Date : 2023-01-01 DOI: 10.32394/rpzh.2023.0284
Rattawan Somporn, Phiman Thirarattanasunthon, Phuwasin Buakate, Suhaila Madeeyo, Soraya Sulong, Saphie Sae

Background: Globally, alcohol consumption is the major cause of mortality and disease. Future health and life quality may also be affected by early initiation of alcohol consumption. It is a cross-sectional design for a research survey.

Objective: This study aimed to investigate alcohol drinking behavior, the effects of alcohol consumption, and factors linked to alcohol drinking behavior among 410 secondary school students in grades 1-3 in the province of Nakhon Si Thammarat in southern Thailand.

Material and methods: A simple sample was selected from a stratified random sample of 210 individuals. The data collection instrument was a questionnaire comprised of five sections and 78 items in total. The index of item objective congruence (IOC) of 0.90 and the reliability of 0.74 was used to evaluate the tool's quality. To analyze the data, descriptive statistics and chi-square statistics were employed.

Results: The results of the study showed that a total of 40.0% of the participants had previously consumed alcohol, that men were more likely than women to drink (54.8%), that beer was the most popular alcoholic beverage (57.7%), that most people drank alcohol at night while at home (47.6%) and with friends (83.6%), the majority of participants (13.9%) drank alcohol one to three times per week, and their attitudes toward alcohol were moderate (85.7%). Religion, knowledge about alcohol use, and the amount of money received each month from habitat for humanity were not found to be linked to drinking alcohol.

Conclusion: The conclusion is that the use of alcohol by students is influenced by a wide variety of circumstances. Health professionals, educational institutions, and relevant agencies should use these factors to promote alcohol use prevention behaviors and formulate guidelines and measures to prevent this by designing an effective prevention program to reduce the alcohol use behaviors of children and young people in the appropriate manner.

背景:在全球范围内,饮酒是导致死亡和疾病的主要原因。过早开始饮酒也会影响未来的健康和生活质量。这是一项横断面设计的研究调查:本研究旨在调查泰国南部那空四他玛拉省 410 名一至三年级中学生的饮酒行为、饮酒的影响以及与饮酒行为相关的因素:从 210 人的分层随机抽样中选取了一个简单样本。数据收集工具是一份调查问卷,包括五个部分共 78 个项目。项目客观一致性指数(IOC)为 0.90,信度为 0.74,用于评价工具的质量。数据分析采用了描述性统计和卡方统计:研究结果表明,共有 40.0% 的参与者以前饮过酒,男性比女性更有可能饮酒(54.8%),啤酒是最受欢迎的酒精饮料(57.7%),大多数人晚上在家饮酒(47.6%)和与朋友一起饮酒(83.6%),大多数参与者(13.9%)每周饮酒一至三次,他们对酒精的态度是温和的(85.7%)。宗教信仰、对饮酒的了解程度以及每月从 "人类栖息地 "获得的资金数额均与饮酒无关:结论:学生饮酒受多种因素的影响。卫生专业人员、教育机构和相关机构应利用这些因素来促进预防饮酒行为,并通过设计有效的预防计划来制定相应的指导方针和措施,以适当的方式减少儿童和青少年的饮酒行为。
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引用次数: 0
Influence of Inula helenium rhizomes and Matricaria chamomilla inflorescences on the biochemical and physiological parameters in male rats fed a high-fat diet. 茵陈根茎和洋甘菊花序对高脂饮食雄性大鼠生化和生理参数的影响
Q2 Medicine Pub Date : 2023-01-01 DOI: 10.32394/rpzh.2023.0281
Maryna Lieshchova, Valentyn Yefimov, Victor Brygadyrenko

Background: Pharmacological correction of a high-fat diet is of great interest to prevent the development of obesity and hypertension. More and more research is being done on the preventive use of medicinal herbs for excess caloric intake.

Objective: The aim of this study was to determine the general physiological effect of I. helenium rhizomes and M. chamomilla inflorescences used in the diet of male rats consuming excess amounts of fat and calories in the daily diet.

Material and methods: In a 30-day experiment, we determined the effect of I. helenium rhizome and M. chamomilla on the physiological activity and metabolic processes of laboratory rats consuming a high-fat diet. The physical activity was evaluated according to the mass gain of animals and change in the relative mass of the internal organs, and also the functional conditions of the central nervous system. The influence on the metabolic processes was revealed by biochemical and clinical blood analyses.

Results: In a laboratory experiment on male rats, it was found that the addition of dry crushed rhizomes of Inula helenium L. and inflorescences of Matricaria chamomilla L. to the diet caused opposite changes in body weight. In the control group, the animals slightly increased their body weight (up to 111.5% of the initial weight by the end of the experiment); the rhizomes of I. helenium caused a decrease in body weight gain (up to 105.5% on the 30th day of the experiment compared to the initial weight); rats fed M. chamomilla inflorescences gained 123.2% of their initial body weight during the month of the experiment. The rhizomes of I. helenium caused an increase in the stomach relative mass. A decrease in the thymus relative weight was observed when animals were fed M. chamomilla inflorescences. The rhizomes of I. helenium stimulated an increase of blood protein concentration (mainly due to globulins), an increase in the alkaline phosphatase activity and cholesterol, and a decrease in the triglycerides concentration. M. chamomilla inflorescences reduced the blood urea concentration and increased the activity of alkaline phosphatase, causing strong changes in fat metabolism. Under the influence of the diet with the addition of M. chamomilla inflorescences, the atherogenic index increased in animals by 6.5 times relatively to the control group (due to a decrease in the concentration of high-density lipoprotein cholesterol and an increase in the concentration of low-density lipoprotein cholesterol, an increase in the total cholesterol concentration). When M. chamomilla was added to the diet, the blood triglycerides concentration in animals decreased sharply and the concentration of leukocytes increased. The concentration of monocytes exceeded the limits of the physiological norm both in the control group and in the group of animals fed on M. chamomilla inflorescences.

Conclusions:

背景:用药物纠正高脂肪饮食对预防肥胖症和高血压的发生具有重要意义。目前,越来越多的研究正在进行中草药预防热量摄入过多的研究:本研究的目的是确定在日常饮食中摄入过量脂肪和热量的雄性大鼠饮食中使用的鹤顶红根茎和洋甘菊花序的一般生理效应:在为期 30 天的实验中,我们测定了鹤顶红根茎和洋甘菊对摄入高脂肪饮食的实验鼠的生理活动和新陈代谢过程的影响。根据动物的体重增加、内脏器官相对质量的变化以及中枢神经系统的功能状况,对大鼠的生理活动进行了评估。生化和临床血液分析表明了运动对新陈代谢过程的影响:在对雄性大鼠进行的实验室实验中发现,在饮食中添加干碎的茵陈根茎和母菊花序会导致体重发生相反的变化。在对照组中,动物的体重略有增加(在实验结束时达到初始体重的 111.5%);茵陈根茎导致体重增加减少(在实验的第 30 天达到初始体重的 105.5%);喂食洋甘菊花序的大鼠在实验的一个月中增加了初始体重的 123.2%。I. helenium的根茎会增加胃的相对质量。给动物喂食洋甘菊花序时,胸腺相对重量有所减少。鹤望兰根茎会刺激血液中蛋白质浓度的增加(主要是球蛋白)、碱性磷酸酶活性和胆固醇的增加以及甘油三酯浓度的降低。洋甘菊花序降低了血液中的尿素浓度,提高了碱性磷酸酶的活性,导致脂肪代谢发生强烈变化。在添加了洋甘菊花序的饮食影响下,动物的动脉粥样硬化指数比对照组增加了 6.5 倍(原因是高密度脂蛋白胆固醇浓度降低,低密度脂蛋白胆固醇浓度增加,总胆固醇浓度增加)。在饮食中添加洋甘菊后,动物血液中的甘油三酯浓度急剧下降,白细胞浓度上升。在对照组和以洋甘菊花序喂养的动物组中,单核细胞的浓度都超过了生理正常值:研究结果表明,有望进一步研究鹤顶红根茎在预防高血压方面的作用,同时也表明,在高脂肪和高热量饮食期间,将洋甘菊花序用于预防目的存在很大风险。
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引用次数: 0
Prevalence and predictors of depression, anxiety, and stress among recovered COVID-19 patients in Vietnam. 越南COVID-19康复患者抑郁、焦虑和压力的患病率及预测因素
Q2 Medicine Pub Date : 2023-01-01 DOI: 10.32394/rpzh.2023.0261
Le Thanh Thao Trang, Cua Ngoc Le, Nirachon Chutipatana, Shamarina Shohaimi, Charuai Suwanbamrung

Background: During the COVID-19 pandemic, a high prevalence of mental health distress has been reported among people who have recovered from the disease.

Objectives: To assess the prevalence of depression, anxiety, and stress as well as identify predictors among recovered COVID-19 patients after more than six months of being discharged in Dong Thap Province, Vietnam.

Material and methods: The cross-sectional study was conducted among 549 eligible participants recruited by stratified sampling. Data was collected using the depression, anxiety and stress scale - 21 items had Content Validity Index = 0.9, and Cronbach's alpha for depression, anxiety and stress sub-scales were 0.95, 0.81, and 0.86, respectively. Descriptive statistics were used to measure the prevalence levels and distribution of characteristics of the participant, while factors influencing depression, anxiety, and stress were predicted using binary logistic regression.

Results: The overall prevalence of depression, anxiety, and stress were 24.8% (95% CI: 21.2-28.6), 41.5% (95% CI: 37.4-45.8), and 25.3% (95% CI: 21.7-29.2), respectively. The predictors of depression were living in urban area (OR = 1.97; 95% CI: 1.27-3.08), holding a bachelor's degree (OR:3.51; 95% CI: 1.13-10.8), having a high monthly income (OR: 2.57; 95% CI: 1.03-6.38), diabetes (OR: 2.21; 95% CI: 1.04-4.68), heart disease (OR: 3.83; 95% CI: 1.79-8.17), respiratory disease (OR: 3.49; 95% CI: 1.24-9.84), and diarrhea (OR: 4.07; 95% CI: 1.06-15.6). Living in the urban area (OR: 1.57; 95% CI: 1.07-2.29), having sleep disturbance (OR: 2.32; 95% CI: 1.56-3.46), and fatigue (OR: 1.57; 95% CI: 1.03-2.39) were predictors for anxiety. Having respiratory disease (OR: 3.75; 95% CI: 1.47-9.60) or diarrhea (OR: 4.34; 95% CI: 1.18-15.9) were predictors of stress.

Conclusion: People who have recovered from COVID-19 should be assessed for symptoms of depression, anxiety, and stress. Primary healthcare providers should develop interventions to support their recovery.

背景:在2019冠状病毒病大流行期间,据报道,在疾病康复者中,精神健康困扰的发生率很高。目的:评估越南同塔省出院6个多月后康复的COVID-19患者抑郁、焦虑和压力的患病率,并确定预测因素。材料与方法:采用分层抽样方法,对549名符合条件的受试者进行横断面研究。采用抑郁、焦虑和压力量表收集数据,其中21个条目的内容效度指数为0.9,抑郁、焦虑和压力子量表的Cronbach's alpha分别为0.95、0.81和0.86。描述性统计用于测量参与者的患病率水平和特征分布,而影响抑郁、焦虑和压力的因素使用二元逻辑回归进行预测。结果:抑郁、焦虑和压力的总体患病率分别为24.8% (95% CI: 21.2-28.6)、41.5% (95% CI: 37.4-45.8)和25.3% (95% CI: 21.7-29.2)。预测抑郁的因素为居住在城市地区(OR = 1.97;95% CI: 1.27-3.08),持有学士学位(OR:3.51;95% CI: 1.13-10.8),月收入高(OR: 2.57;95% CI: 1.03-6.38),糖尿病(OR: 2.21;95% CI: 1.04-4.68),心脏病(OR: 3.83;95% CI: 1.79-8.17),呼吸系统疾病(OR: 3.49;95% CI: 1.24-9.84)和腹泻(OR: 4.07;95% ci: 1.06-15.6)。居住在市区(OR: 1.57;95% CI: 1.07-2.29),有睡眠障碍(OR: 2.32;95% CI: 1.56-3.46)和疲劳(OR: 1.57;95% CI: 1.03-2.39)是焦虑的预测因子。患有呼吸道疾病(OR: 3.75;95% CI: 1.47-9.60)或腹泻(or: 4.34;95% CI: 1.18-15.9)是压力的预测因子。结论:应对COVID-19康复者进行抑郁、焦虑和压力症状评估。初级卫生保健提供者应制定干预措施以支持其康复。
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引用次数: 0
Benefits of sea buckthorn juice consumption in women of productive age with hypercholesterolemia. 食用沙棘汁对高胆固醇血症生育年龄妇女的益处。
Q2 Medicine Pub Date : 2023-01-01 DOI: 10.32394/rpzh.2023.0258
Jana Kopčeková, Jana Mrázová, Katarína Fatrcová-Šramková, Marta Habánová, Martina Gažarová, Petra Lenártová

Background: Sea buckthorn contains almost 200 nutrients and bioactive substances, including phenolic compounds such as flavonoids, vitamins, proteins, amino acids, minerals, alkaloids, chlorophyll derivatives, amines, organic acids, fatty acids and phytosterols. Human and animal studies suggest that sea buckthorn may have a variety of beneficial effects: cardioprotective, antiatherogenic, antioxidant, anticancer, immunomodulatory, antibacterial, antiviral and antiinflammatory.

Objective: The aim of this study was to evaluate the effect of regular consumption of 100% sea buckthorn juice on the risk factors of cardiovascular diseases in women of productive age with hypercholesterolemia.

Material and methods: A clinical study involved 19 women with a mean age of 54.06 ±2.97 years who consumed 50 mL of sea buckthorn juice daily for 8 weeks. Anthropometric and biochemical parameters in blood serum were monitored before the start of sea buckthorn consumption and after 8 weeks of consumption. Body composition was determined using an multifrequency analyzer InBody720. Routine biochemical analyzes were performed by standard methods in an accredited laboratory of the University Hospital by automatic biochemical analyzer BioMajesty JCA-BM6010/C. Statistical comparison between individual measurements was performed using a paired t-test, using Statistica Cz version 10 (TIBCO Software, Inc., Palo Alto, CA, USA).

Results: We observed significant decrease of body weight, body mass index (P<0.05), body fat and visceral fat (P<0.001) after 8 weeks of consumption of 100% sea buckthorn juice. In this intervention study, we observed a significant decrease in low-density cholesterol (P˂0.05) and a significant increase in high-density cholesterol (P˂0.001). The level of triglycerides was similar at the end of the study (P>0.05). After the intervention, we observed decrease of orosomucoid, immunoglobulin A, immunoglobulin G, immunoglobulin M (P<0.001) and C-reactive protein (P<0.01).

Conclusions: The obtained results support the hypothesis that the daily consumption of sea buckthorn juice for eight weeks could contribute to the beneficial effects of reducing the risk of cardiovascular diseases, such as the reduction of body and visceral fat, LDL-C, CRP and the increase of HDL-C.

背景:沙棘含有近200种营养物质和生物活性物质,包括类黄酮、维生素、蛋白质、氨基酸、矿物质、生物碱、叶绿素衍生物、胺、有机酸、脂肪酸和植物甾醇等酚类化合物。人体和动物研究表明,沙棘可能具有多种有益作用:保护心脏、抗动脉粥样硬化、抗氧化、抗癌、免疫调节、抗菌、抗病毒和抗炎。目的:本研究的目的是评估定期食用100%沙棘汁对育龄妇女高胆固醇血症心血管疾病危险因素的影响。材料与方法:19名平均年龄为54.06±2.97岁的女性,连续8周每天饮用50 mL沙棘汁。在沙棘开始进食前和进食8周后监测血清的人体测量和生化参数。使用InBody720多频分析仪测定体成分。常规生化分析在大学医院认可实验室采用BioMajesty JCA-BM6010/C全自动生化分析仪,按标准方法进行。使用Statistica Cz version 10 (TIBCO Software, Inc., Palo Alto, CA, USA),使用配对t检验进行个体测量之间的统计比较。结果:患者体重、体质指数明显下降(P0.05)。干预后,我们观察到orosomucoid,免疫球蛋白A,免疫球蛋白G,免疫球蛋白M (p)的降低。结论:我们得到的结果支持了假设,每天饮用沙棘汁8周可以降低体脂和内脏脂肪,降低LDL-C, CRP,升高HDL-C,有助于降低心血管疾病的风险。
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引用次数: 0
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Roczniki Panstwowego Zakladu Higieny
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