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Barriers and strategies to improve digital mental health intervention uptake among college students of color: A modified Delphi study 提高有色人种大学生数字心理健康干预接受率的障碍和策略:一项改进的德尔菲研究
Q3 PSYCHIATRY Pub Date : 2023-03-01 DOI: 10.1016/j.jbct.2022.12.002
Tamar Kodish , Stephen M. Schueller , Anna S. Lau

Purpose

Digital mental health interventions (DMHI) may enhance equity in college student mental health, but engagement with them is poor. Little is known about barriers and strategies to enhance DMHI uptake among college students of color. The goal of this study was to attain expert consensus on important barriers to DMHI uptake and important and feasible engagement strategies to enhance DMHI uptake among college students of color.

Methods

The study utilized a modified, three-round Delphi survey. Researcher and industry stakeholders with relevant expertise participated (n = 35). Across rounds, experts generated and rated the importance and feasibility of barriers and strategies to promote DMHI uptake for students of color. Experts viewed group consensus and importance ratings between rounds and were provided the opportunity to re-rate items. Barriers and strategies were coded into frameworks using rapid qualitative analysis and grounded theory techniques.

Results

A total of n = 63 barriers and n = 64 strategies were derived, and consensus on level of importance was met for 98% of barriers and strategies. Key barriers included mistrust of mental health services and lack of culturally responsive care. Strategies spanned levels of implementation and emphasized codesign, diverse representation, reducing user burden, addressing privacy issues, and embedding DMHI within existing infrastructure.

Conclusions

This study identified barriers and strategies for improving DMHI uptake for college students of color. The subset of highly feasible and important engagement strategies derived in this study provides direction for the design of scalable engagement interventions with the potential to improve DMHI implementation and reduce disparities in care receipt.

目的数字心理健康干预(DMHI)可以提高大学生心理健康的公平性,但参与度很低。人们对提高有色人种大学生DMHI吸收率的障碍和策略知之甚少。本研究的目的是就DMHI吸收的重要障碍以及提高有色人种大学生DMHI吸收率的重要可行的参与策略达成专家共识。方法采用改良的三轮德尔菲调查。具有相关专业知识的研究人员和行业利益相关者参加了会议(n=35)。在多轮调查中,专家们提出并评估了促进有色人种学生接受DMHI的障碍和策略的重要性和可行性。专家们查看了小组共识和各轮之间的重要性评级,并有机会对项目进行重新评级。使用快速定性分析和基础理论技术将障碍和战略编码为框架。结果共推导出n=63个障碍和n=64个策略,98%的障碍和策略在重要性水平上达成共识。主要障碍包括对心理健康服务的不信任以及缺乏文化上有响应能力的护理。战略跨越了实施层面,强调代码设计、多样性表示、减少用户负担、解决隐私问题以及在现有基础设施中嵌入DMHI。结论本研究确定了提高有色人种大学生DMHI吸收的障碍和策略。本研究中得出的高度可行和重要的参与策略子集为设计可扩展的参与干预措施提供了方向,有可能改善DMHI的实施并减少护理接收的差异。
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引用次数: 1
Improving uptake of mental health crisis resources: Randomized test of a single-session intervention embedded in social media 提高心理健康危机资源的利用率:嵌入社交媒体的单次干预的随机测试
Q3 PSYCHIATRY Pub Date : 2023-03-01 DOI: 10.1016/j.jbct.2022.12.001
Katherine Cohen , Mallory Dobias , Robert Morris , Jessica Schleider

Young people often experience difficulties accessing mental health support. In moments of crisis, many young people search for mental health-related information or support on social media platforms. When users search or post crisis-related content (e.g., “suicide”) on these platforms, many are programmed to automatically provide the user with crisis hotlines. Little research has examined whether young people use crisis hotlines when they are automatically shared, or whether other resource-provision strategies may better support hope and help-seeking.

Methods

Users flagged as being potentially in-crisis by social media platforms were referred to Koko—a nonprofit that partners with online platforms to provide crisis support. Users were randomized to receive either a typical crisis response (988 crisis hotline provision) or a one-minute, enhanced crisis response Single-Session Intervention (SSI).

Results

Users who received the enhanced crisis response SSI reported greater decreases in hopelessness ten minutes later, compared to users who received the typical crisis response (t(153) = -2.16, p = 0.03, d = -0.35; 95 % CI, −0.67, −0.03). Users who received the SSI were more than twice as likely to report using the resources provided to them, compared to users who received the typical crisis response (78.02 % vs 38.64 %; χ2(1) = 27.02, p < 0.001, V = 0.28).

Conclusion

An enhanced crisis response SSI embedded within social media platforms can reduce users’ hopelessness and dramatically increase young people’s odds of accessing mental health resources in moments of crisis.

年轻人在获得心理健康支持方面经常遇到困难。在危机时刻,许多年轻人在社交媒体平台上搜索与心理健康相关的信息或支持。当用户在这些平台上搜索或发布与危机相关的内容(例如“自杀”)时,许多平台被编程为自动为用户提供危机热线。很少有研究调查年轻人在自动共享危机热线时是否会使用这些热线,或者其他资源提供策略是否可以更好地支持希望和寻求帮助。方法被社交媒体平台标记为潜在危机的用户被推荐给Koko,这是一家与在线平台合作提供危机支持的非营利组织。用户被随机分配接受典型的危机响应(988危机热线)或一分钟的强化危机响应单会话干预(SSI)。结果与接受典型危机反应的用户相比,接受强化危机反应SSI的用户在10分钟后的绝望感下降幅度更大(t(153)=-2.16,p=0.03,d=-0.35;95%CI,-0.67,-0.03)。与接受典型危机响应的用户相比,接受SSI的用户报告使用提供给他们的资源的可能性是接受典型危机反应的用户的两倍多(78.02%vs 38.64%;χ2(1)=27.02,p<;0.001,V=0.28)。结论在社交媒体平台中嵌入增强的危机应对SSI可以减少用户的绝望情绪,并显著增加年轻人在危机时刻获得心理健康资源的几率。
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引用次数: 1
Pilot study of an undergraduate college course to support student mental health: Wellness and resilience for college and beyond 支持学生心理健康的本科课程试点研究:大学及以后的健康和恢复力
Q3 PSYCHIATRY Pub Date : 2023-03-01 DOI: 10.1016/j.jbct.2022.09.001
Carla D. Chugani , James J. Mazza , Barbara J. Fuhrman , Janine Talis , Courtney Murphy , Elizabeth Miller , Robert W.S. Coulter

The purpose of this study was to investigate preliminary outcomes associated with an undergraduate course titled, “Wellness and Resilience for College and Beyond” (WRC), which teaches students evidence-based skills for emotional health. Three campuses in Southwestern Pennsylvania with no previous experience delivering this course implemented the one-semester WRC during the Fall 2019 semester; 24 students completed a baseline survey and at least 1 follow-up survey. Participants completed electronic surveys at baseline, post-semester, and 3-month follow-up. Paired t-tests were used to compare baseline scores to scores at post-semester and 3-month follow-up. At post-semester, students reported significant improvements in psychological inflexibility, resilience, mindfulness, emotion dysregulation, distress tolerance, life satisfaction, dysfunctional coping, and adaptive skills use. With the exceptions of life satisfaction and emotion dysregulation, significant gains were maintained at 3-month follow-up. Notably, the follow-up assessment occurred at the beginning of the COVID-19 lockdown in the U.S. (March 2020), which may have affected life satisfaction and emotion dysregulation for participants. There was a nonsignificant decline in anxiety at post-semester which became statistically significant at 3-month follow-up. These preliminary data show proof of concept that WRC can be implemented successfully on new campuses with no previous expertise in this course and can achieve meaningful improvements on several emotional health outcomes with high relevance to collegiate mental health. In addition to these data, barriers to implementation and scale-up are discussed at length with “lessons learned” that may have broad relevance to the implementation of emotional wellbeing coursework in higher education and support such efforts to address student mental health at the population level.

本研究的目的是调查与一门名为“大学及以后的健康与韧性”(WRC)的本科生课程相关的初步结果,该课程教授学生基于证据的情绪健康技能。宾夕法尼亚州西南部的三个校区在2019年秋季学期实施了为期一学期的WRC,之前没有提供该课程的经验;24名学生完成了一项基线调查和至少一项后续调查。参与者在基线、学期后和3个月的随访中完成了电子调查。配对t检验用于将基线得分与学期后和3个月随访的得分进行比较。在学期后,学生们报告说,他们在心理灵活性、韧性、正念、情绪失调、痛苦容忍、生活满意度、应对能力和适应性技能使用方面有了显著改善。除了生活满意度和情绪失调外,在3个月的随访中保持了显著的改善。值得注意的是,后续评估发生在美国新冠肺炎封锁开始时(2020年3月),这可能影响了参与者的生活满意度和情绪调节障碍。焦虑在学期后没有显著下降,在3个月的随访中变得具有统计学意义。这些初步数据证明了WRC可以在新校区成功实施,而之前没有该课程的专业知识,并且可以在与大学心理健康高度相关的几个情绪健康结果方面取得有意义的改善。除了这些数据外,还详细讨论了实施和扩大的障碍,以及可能与高等教育中情感健康课程的实施有广泛相关性的“经验教训”,并支持在人口层面解决学生心理健康问题。
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引用次数: 2
Predicting cognitive-behavioral therapy outcomes for bulimia nervosa patients based on skill use during treatment 基于治疗过程中的技能使用预测神经性贪食症患者的认知行为治疗结果
Q3 PSYCHIATRY Pub Date : 2023-03-01 DOI: 10.1016/j.jbct.2023.02.003
Olivia M. Clancy , Adrienne S. Juarascio , Stephanie M. Manasse , Paakhi Srivastava

Cognitive-behavioral therapy (CBT-E) is the most widely researched and effective treatment for bulimia nervosa (BN). CBT-E for BN emphasizes the importance of therapeutic skills utilization as consistent skill utilization is proposed to drive treatment outcomes. Despite its theoretical importance, there is limited research on skill use during BN treatment and its impact on BN symptoms. The current study was an exploratory analysis of whether skills utilization during CBT for BN were associated with improvements in BN at post-treatment. Participants (N = 54) with BN-spectrum eating disorders received 16 weekly sessions of individual CBT-E, in which they were taught six core skills designed to reduce BN symptoms. After each session, clinicians rated the degree of skills utilization by participants during the past week. Linear regressions were used to examine whether within-person averages of utilization of each of the six skills were related to treatment outcomes (measured as reduction in binge eating and EDE global scores assessed via the Eating Disorders Examination Global Scale) at post treatment and follow up. Higher average use of all six skills during treatment predicted improvements in global eating pathology at post treatment and follow up. There was no relationship found between skill use and improvements in binge eating at post treatment, however, all six skills except regular eating skill predicted improvements in binge eating at follow up. These findings suggest that greater utilization of skills is crucial in maximizing treatment gains for BN patients. Future studies should explore ways to increase the acceptability and utilization of these skills.

认知行为疗法(CBT-E)是研究最广泛、治疗神经性贪食症(BN)最有效的方法。BN的CBT-E强调了治疗技能利用的重要性,因为一致的技能利用被提议来推动治疗结果。尽管它在理论上很重要,但对BN治疗过程中的技能使用及其对BN症状的影响的研究有限。目前的研究是对BN CBT期间的技能利用率是否与治疗后BN的改善有关的探索性分析。患有BN谱系饮食障碍的参与者(N=54)每周接受16次CBT-E个体训练,在训练中,他们被教授了六项旨在减少BN症状的核心技能。每次会议结束后,临床医生对参与者在过去一周内的技能利用程度进行评分。在治疗后和随访中,使用线性回归来检查六项技能中每一项的人内平均使用率是否与治疗结果有关(通过饮食障碍检查全球量表评估的暴饮和EDE全球评分的减少)。在治疗期间,所有六项技能的平均使用率较高,预示着治疗后和随访时整体饮食病理学的改善。在治疗后,没有发现技能使用与暴饮的改善之间的关系,然而,除常规饮食技能外,所有六项技能都预测了随访时暴饮的改进。这些发现表明,更多地利用技能对于最大限度地提高BN患者的治疗效果至关重要。未来的研究应该探索如何提高这些技能的可接受性和利用率。
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引用次数: 1
Co-developing tools to support student mental health and substance use: Minder app development from conceptualization to realization 共同开发支持学生心理健康和物质使用的工具:从概念化到实现的Minder应用程序开发
Q3 PSYCHIATRY Pub Date : 2023-03-01 DOI: 10.1016/j.jbct.2023.02.002
Melissa Vereschagin , Angel Y. Wang , Calista Leung , Chris G. Richardson , Kristen L. Hudec , Quynh Doan , Punit Virk , Priyanka Halli , Katharine D. Wojcik , Lonna Munro , Brandon S. Chai , Tiana Mori , Matthew Sha , Em Mittertreiner , Amar Farkouh , Duke Sigamany , Daniel V. Vigo

University students experience a high prevalence of mental health and substance use concerns; however, few students access support for these challenges. Although digital mental health interventions have been promoted as a means of addressing this need, engagement with these tools is often poor. A lack of user-centric design is frequently cited as a reason for low engagement. The goal of this study is to describe the co-development processes and associated feedback used to develop the Minder app, a tool designed to support a non-clinical population of university students to maintain mental wellbeing and manage substance use. This process can be organized into three main phases: conceptualization and initial app design, iterative user testing, and final app design. As a result of meaningful engagement with end-users throughout the design and testing process, key changes were made to the design (e.g., graphical interface), content (e.g., language used, addition of components related to general wellbeing), and support (e.g., peer coaching) provided within the app. In addition to describing these changes, we also discuss considerations related to the broader implementation and scale-up of the Minder app within existing university systems.

大学生普遍存在心理健康和物质使用问题;然而,很少有学生能够获得这些挑战的支持。尽管数字心理健康干预作为解决这一需求的一种手段得到了推广,但对这些工具的参与往往很差。缺乏以用户为中心的设计经常被认为是参与度低的原因。这项研究的目标是描述用于开发Minder应用程序的共同开发过程和相关反馈,该应用程序旨在支持非临床大学生群体保持心理健康和管理药物使用。这个过程可以分为三个主要阶段:概念化和初始应用程序设计、迭代用户测试和最终应用程序设计。由于在整个设计和测试过程中与最终用户进行了有意义的接触,对应用程序内提供的设计(例如图形界面)、内容(例如使用的语言、添加与总体健康相关的组件)和支持(例如同伴辅导)进行了关键更改。除了描述这些变化,我们还讨论了在现有大学系统中更广泛地实施和扩大Minder应用程序的相关考虑因素。
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引用次数: 1
A single-group pilot feasibility and acceptability study of the Broad Minded Affective Coping technique for suicidal adults in crisis 胸怀情感应对技术在成人危机自杀中的可行性及可接受性研究
Q3 PSYCHIATRY Pub Date : 2022-11-01 DOI: 10.1016/j.jbct.2022.07.002
D. Pratt , H. Mitchell , L. Fitzpatrick , J. Lea

The evidence base for psychological interventions for suicidal individuals is limited and the delivery of longer-term therapy within mental health crisis services is confronted by several barriers. For these reasons, identifying briefer techniques that can be delivered to at-risk groups is pertinent. This study provides a preliminary evaluation of the Broad Minded Affective Coping (BMAC) technique, a brief positive mental imagery intervention, for suicidal adults. Of 32 individuals referred by mental health crisis services, 14 adults with experience of suicidal ideation in the past three months took part. All participants received a one-session BMAC brief intervention, and invited to practice the BMAC independently for the next seven days and provide logbook ratings of pre-post BMAC mood states. Suicidal ideation and depression were assessed at baseline and at the end of the week of imagery practice. Nine participants (64%) completed the study by providing baseline and follow-up assessments of depression and suicidal ideation, completing a logbook and participating in a feedback interview. The BMAC appeared acceptable to participants and showed promise in improving mood and suicidal thoughts. We discuss the implications of these findings for future investigations of a one-session BMAC brief intervention.

对有自杀倾向者进行心理干预的证据基础有限,在心理健康危机服务机构内提供长期治疗面临若干障碍。由于这些原因,确定可以交付给风险群体的更简短的技术是相关的。本研究提供了一个初步评估的宽心情感应对(BMAC)技术,一个简短的积极的心理意象干预,自杀的成年人。在心理健康危机服务中心转介的32名患者中,14名在过去三个月内有过自杀念头的成年人参加了研究。所有参与者都接受了一次简短的BMAC干预,并被邀请在接下来的七天内独立练习BMAC,并提供BMAC前后情绪状态的日志评级。自杀意念和抑郁在基线和意象练习周结束时进行评估。9名参与者(64%)通过提供抑郁和自杀意念的基线和随访评估、填写日志和参与反馈访谈完成了研究。BMAC似乎可以被参与者接受,并有望改善情绪和自杀念头。我们讨论了这些发现对未来一次BMAC短暂干预研究的意义。
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引用次数: 1
Exposurepedia: A pilot study of a web-tool to support the implementation of exposure therapy for anxiety-related disorders 曝光:一个网络工具的试点研究,以支持对焦虑相关障碍的暴露疗法的实施
Q3 PSYCHIATRY Pub Date : 2022-11-01 DOI: 10.1016/j.jbct.2022.06.001
Rachel A. Schwartz , Lisa D. Yankowitz , Lily A. Brown

Despite robust empirical support, exposure therapy is severely underutilized in routine clinical care. Clinicians’ perception of exposure therapy as too difficult is a key but largely unaddressed barrier to implementation. This pilot study sought to evaluate the acceptability and feasibility of a novel clinical web-tool—Exposurepedia—designed to support the implementation of exposure therapy for anxiety-related disorders by alleviating its perceived difficulty. Clinicians in an anxiety specialty clinic were given access to Exposurepedia. Of 20 eligible clinicians, 16 (80%) voluntarily registered for the website. Of those who registered, 13 (81%) used the website at least once and 10 (77% of users) became repeat users. Over the 6-week pilot, Exposurepedia was accessed 46 times (M = 7.7 times per week; SD = 2.8). Clinicians reported in majority that Exposurepedia made exposure therapy easier, saved them time, was easy to use, and increased their confidence in doing exposures. Clinicians are interested in using Exposurepedia and found the tool to be both acceptable and feasible in alleviating the intellectual, logistical, and emotional demands of exposure therapy. This pilot provides the basis for future research seeking to further develop and evaluate this novel digital implementation support tool.

尽管有强有力的经验支持,暴露疗法在常规临床护理中严重不足。临床医生认为暴露疗法太难,这是实施的关键障碍,但在很大程度上没有得到解决。本初步研究旨在评估一种新型临床网络工具的可接受性和可行性,该工具旨在通过减轻焦虑相关障碍的感知困难来支持暴露疗法的实施。一家焦虑专科诊所的临床医生被允许使用暴露媒体。在20名合格的临床医生中,16名(80%)自愿注册了该网站。在注册用户中,13人(81%)至少使用过一次网站,10人(77%)成为重复用户。在6周的试验中,访问了46次Exposurepedia (M = 7.7次/周;sd = 2.8)。大多数临床医生报告说,exposure surepedia使暴露治疗更容易,节省了他们的时间,易于使用,并增加了他们进行暴露的信心。临床医生对使用暴露疗法很感兴趣,并发现该工具在减轻暴露疗法的智力、后勤和情感需求方面既可接受又可行。该试点为寻求进一步开发和评估这种新型数字实施支持工具的未来研究提供了基础。
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引用次数: 0
Emotional clarity and awareness predict obsessive–compulsive disorder symptoms during exposure and response prevention in a naturalistic treatment sample 情绪清晰度和意识预测强迫症症状期间暴露和反应预防在一个自然的治疗样本
Q3 PSYCHIATRY Pub Date : 2022-11-01 DOI: 10.1016/j.jbct.2022.07.001
Keith Bredemeier, Wenting Mu, Lindiwe Mayinja, Lily A. Brown

Obsessive-compulsive disorder (OCD) is associated with “emotional disconnections” (e.g., difficulty understanding your emotions), but very limited work has examined these links prospectively or in the context of OCD treatment. This study tested the hypotheses that emotional clarity and emotional awareness would predict improvement in OCD symptoms during Exposure and Response Prevention (ExRP) in a naturalistic treatment sample, based on the putative impact of these factors on emotional processing. We tested the effect of baseline levels of emotional clarity and awareness (measured using the Difficulties in Emotion Regulation Scale) on OCD symptoms at baseline, mid- and post-treatment (Obsessive-Compulsive Inventory, Revised) in a study of adults diagnosed with OCD and receiving ExRP in an open treatment clinic (N = 131) using multilevel modeling. Both lack of emotional clarity and lack of emotional awareness predicted OCD symptom severity at post-treatment. Lack of awareness also predicted greater improvement in OCD symptoms during treatment, while clarity did not. Consistent with previous research, individuals who reported being less clear about their emotions had more severe OCD symptoms at post-treatment. Extending previous findings, those who reported being more aware of their emotions before treatment showed less symptom improvement during treatment. Clinical and theoretical implications of these findings are discussed.

强迫症(OCD)与“情感脱节”(例如,难以理解自己的情绪)有关,但对这些联系的前瞻性或在强迫症治疗背景下的研究非常有限。本研究在自然主义治疗样本中测试了情绪清晰和情绪意识可以预测暴露和反应预防(ExRP)期间强迫症症状改善的假设,基于这些因素对情绪处理的假设影响。我们测试了情绪清晰度和意识基线水平(使用情绪调节困难量表测量)在基线、治疗中期和治疗后(强迫症量表,修订版)对强迫症症状的影响,在一项被诊断为强迫症并在开放治疗诊所接受ExRP的成年人(N = 131)的研究中使用多层模型。缺乏情绪清晰度和缺乏情绪意识都预示着治疗后强迫症症状的严重程度。在治疗期间,缺乏意识也预示着强迫症症状会有更大的改善,而清醒则不然。与之前的研究一致,那些对自己的情绪不太清楚的人在治疗后出现了更严重的强迫症症状。扩展先前的研究结果,那些在治疗前报告更了解自己情绪的人在治疗期间症状改善较少。讨论了这些发现的临床和理论意义。
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引用次数: 0
Mindfulness-informed (ACT) and Mindfulness-based Programs (MBSR/MBCT) applied for college students to reduce symptoms of depression and anxiety 正念通知(ACT)和正念基础项目(MBSR/MBCT)适用于大学生,以减轻抑郁和焦虑的症状
Q3 PSYCHIATRY Pub Date : 2022-11-01 DOI: 10.1016/j.jbct.2022.05.002
Liang Ma , Yanjie Wang , Le Pan , Zeshi Cui , Philip J. Schluter

This meta-analysis examines the effects of mindfulness-informed and mindfulness-based interventions including acceptance and commitment therapy (ACT), mindfulness-based stress reduction (MBSR), and mindfulness-based cognitive therapy (MBCT) on depressive and anxiety symptoms among college students. Three electronic databases (PubMed, PsycINFO, and Cochrane Central) were utilized and systematically searched. Effect estimates were reported as standardized mean differences (SMDs) and data were pooled using random-effects models. Twenty-two comparisons derived from 19 studies (2716 participants) were included in the meta-analysis. For studies employing passive control conditions (n = 17), post-intervention effect sizes were significant for depressive (0.47 [95% CI: 0. 32–0.63]) and anxiety symptoms (0.58 [95% CI: 0.34–0.82]). Effect sizes were significant at post-intervention among MBCT (0.76 [95% CI: 0.48–1.03] for depressive symptoms and 1.37 [95% CI: 0.70–2.04] for anxiety symptoms) and MBSR (0.58 [95% CI: 0.31–0.86] for depressive symptoms and 0.49 [95% CI: 0.24–0.73] for anxiety symptoms). The effect size of ACT for depressive symptoms at post-intervention was significant (0.28 [95% CI: 0.09–0.48]), but the post-intervention effect size of ACT for anxiety symptoms was not significant (0.23 [95% CI: −0.01 −0.47]). Our analyses showed no superiority for ACT, MBSR, and MBCT to active control conditions, either when they were combined or considered separately. This meta-analysis provides empirical evidence in support of ACT, MBSR, and MBCT for reducing depressive and anxiety symptoms among college students.

本荟萃分析考察了正念干预和正念干预对大学生抑郁和焦虑症状的影响,包括接受和承诺疗法(ACT)、正念减压疗法(MBSR)和正念认知疗法(MBCT)。三个电子数据库(PubMed, PsycINFO和Cochrane Central)被利用并系统地检索。效应估计以标准化平均差异(SMDs)报告,数据采用随机效应模型汇总。meta分析包括来自19项研究(2716名参与者)的22个比较。对于采用被动控制条件的研究(n = 17),干预后对抑郁症的效应量显著(0.47 [95% CI: 0。32-0.63])和焦虑症状(0.58 [95% CI: 0.34-0.82])。干预后MBCT(抑郁症状为0.76 [95% CI: 0.48-1.03],焦虑症状为1.37 [95% CI: 0.70-2.04])和MBSR(抑郁症状为0.58 [95% CI: 0.31-0.86],焦虑症状为0.49 [95% CI: 0.24-0.73])的效应量显著。干预后ACT对抑郁症状的效应量显著(0.28 [95% CI: 0.09-0.48]),但ACT对焦虑症状的干预后效应量不显著(0.23 [95% CI: - 0.01 - 0.47])。我们的分析显示ACT、MBSR和MBCT在主动控制条件下没有优势,无论是联合使用还是单独考虑。本荟萃分析提供了实证证据,支持ACT、MBSR和MBCT在减轻大学生抑郁和焦虑症状方面的作用。
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引用次数: 3
Quetiapine as an adjunct to enhance engagement in prolonged exposure therapy for PTSD in veterans: A randomized, pilot trial 奎硫平辅助提高退伍军人PTSD长期暴露治疗的参与度:一项随机、试点试验
Q3 PSYCHIATRY Pub Date : 2022-11-01 DOI: 10.1016/j.jbct.2022.04.001
Muhammad R. Baig , Jennifer L. Wilson , Robert D. Beck , Jennifer A. Lemmer , Anna L. Hernandez , Adeel Meraj , Rebecca N. Tapia , Eric C. Meyer , Jim Mintz , Alan L. Peterson , John D. Roache

Despite established efficacy, there is low engagement in prolonged exposure (PE) therapy for PTSD among combat veterans. In preparation for a full-scale randomized trial, we sought to evaluate the feasibility, safety, and preliminary efficacy of quetiapine to enhance patient engagement in PE therapy. Open-label, randomized pilot trial of quetiapine monotherapy vs. Treatment as Usual (TAU) medications in 20 military veterans with combat related PTSD who were seeking care from the San Antonio Polytrauma Rehabilitation Center at the South Texas Veterans Healthcare System (STVHCS). Participants were randomized to receive either Quetiapine (n = 10) monotherapy or pharmacological TAU (n = 10) in patients who were receiving PE as a standard of care therapy. We collected information on (1) the number of potentially eligible veterans approached, the number screened, and the number randomized, (2) adverse events reported, (3) number of participants continuing PE treatment at least until session #4 (i.e., after first exposure session) and the total number of sessions of PE completed by the participants, and (4) change in PTSD severity and sleep quality measured by the PTSD Checklist for DSM-5 (PCL-5) and Pittsburgh Sleep Quality Index (PSQI). Data were analyzed for 18 intent-to-treat participants with mean (SD) age, 53.5 (13.4) years; and baseline PCL-5 score, 57.6 (7.6). More veterans in the quetiapine group (n = 9; 100%) received at least the first exposure session of PE therapy compared to TAU ((n = 3; (37.5%), p = .006] and completed PE therapy (n = 8; (88.9%) vs (n = 3; (37.5%), p = .03). Both PCL-5 (p = .03) and PSQI (p = .02) scores decreased significantly more for participants in the quetiapine than the TAU group. Preliminary findings support the feasibility, safety, and possible efficacy of quetiapine as an adjunct to enhancing engagement in PE therapy. A full-scale randomized trial is required to determine the true efficacy of quetiapine to enhance engagement in PE treatment.

尽管有既定的疗效,但长期暴露(PE)治疗退伍军人创伤后应激障碍的参与度很低。为了准备一项全面的随机试验,我们试图评估喹硫平提高患者参与体育治疗的可行性、安全性和初步疗效。开放标签,随机试点试验喹硫平单药与常规治疗(TAU)药物在20名退伍军人与战斗相关的创伤后应激障碍谁寻求护理圣安东尼奥多创伤康复中心在南德克萨斯退伍军人医疗保健系统(STVHCS)。在接受PE作为标准护理治疗的患者中,参与者被随机分配接受喹硫平(n = 10)单药治疗或药理学TAU (n = 10)。我们收集了以下信息:(1)接近的潜在合格退伍军人的数量,筛选的数量和随机的数量,(2)报告的不良事件,(3)至少在第4阶段(即第一次暴露阶段后)继续PE治疗的参与者数量和参与者完成的PE治疗的总次数,以及(4)PTSD严重程度和睡眠质量的变化通过DSM-5的PTSD检查表(PCL-5)和匹兹堡睡眠质量指数(PSQI)测量。对18名意向治疗参与者的数据进行分析,平均(SD)年龄为53.5(13.4)岁;基线PCL-5评分57.6分(7.6分)。喹硫平组退伍军人较多(n = 9;100%)与TAU相比,至少接受了第一次PE治疗((n = 3;(37.5%), p = 0.006]并完成PE治疗(n = 8;(88.9%) vs (n = 3;(37.5%), p = .03)。与TAU组相比,喹硫平组的PCL-5 (p = 0.03)和PSQI (p = 0.02)得分均显著下降。初步研究结果支持喹硫平作为体育治疗辅助手段的可行性、安全性和可能的有效性。需要一项全面的随机试验来确定喹硫平在PE治疗中提高参与度的真正功效。
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Journal of Behavioral and Cognitive Therapy
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