Pub Date : 2017-11-01DOI: 10.4103/MJDRDYPU.MJDRDYPU_37_17
Asha Varghese, T. Shibu, M. Pushpalatha
A 21-day-old male infant, born as the first child to a nonconsanguineous couple, presented with nonspecific symptoms, signs, and superimposed infection. Investigations conducted were not conclusive to arrive at a diagnosis. In 6 days, the infant succumbed to his condition. Postmortem samples were analyzed for metabolic substances, and liver biopsy was done. Urine metabolic screening showed the presence of amino acids and reducing substance. Further analysis proved the presence of galactose, generalized aminoaciduria, and liver biopsy with features of inborn error of metabolism. Further samples for higher investigations were not available, which draws attention to the need of being able to diagnose the condition early enough to save lives. We are suggesting a helpful, easy to perform, and cheap diagnostic test algorithm for diagnosing galactosemia in resource-poor settings.
{"title":"Crystals hold the clue","authors":"Asha Varghese, T. Shibu, M. Pushpalatha","doi":"10.4103/MJDRDYPU.MJDRDYPU_37_17","DOIUrl":"https://doi.org/10.4103/MJDRDYPU.MJDRDYPU_37_17","url":null,"abstract":"A 21-day-old male infant, born as the first child to a nonconsanguineous couple, presented with nonspecific symptoms, signs, and superimposed infection. Investigations conducted were not conclusive to arrive at a diagnosis. In 6 days, the infant succumbed to his condition. Postmortem samples were analyzed for metabolic substances, and liver biopsy was done. Urine metabolic screening showed the presence of amino acids and reducing substance. Further analysis proved the presence of galactose, generalized aminoaciduria, and liver biopsy with features of inborn error of metabolism. Further samples for higher investigations were not available, which draws attention to the need of being able to diagnose the condition early enough to save lives. We are suggesting a helpful, easy to perform, and cheap diagnostic test algorithm for diagnosing galactosemia in resource-poor settings.","PeriodicalId":36033,"journal":{"name":"Medical Journal of Dr. D.Y. Patil University","volume":"10 1","pages":"582 - 584"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42231986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.4103/MJDRDYPU.MJDRDYPU_294_16
Rajeshwari K Muthusamy, S. Mehta, A. Venus, B. Rangarajan
Melanoma of mucosal sites is rare and is extremely rare in esophagus. Melanoma is known for its histological diversity mimicking any other malignancies with poor prognosis. Clinical presentation may be similar to other gastroesophageal junction malignancies with obstructive symptoms/bleeding with pigmented polypoid mass on endoscopy and gross examination. However, metastasis from elsewhere is to be considered in the absence of melanocytosis in the adjacent squamous epithelium. Immunohistochemistry with a panel of markers is necessary in amelanotic lesions, poorly differentiated morphology, and small biopsy specimens. We report a case of melanoma with plasmacytoid features in the gastroesophageal junction diagnosed in a small biopsy with immunohistochemical findings and follow-up esophagogastrectomy.
{"title":"Primary malignant melanoma of the gastroesophageal junction with plasmacytoid features and reactivity to cd138: A case report and review","authors":"Rajeshwari K Muthusamy, S. Mehta, A. Venus, B. Rangarajan","doi":"10.4103/MJDRDYPU.MJDRDYPU_294_16","DOIUrl":"https://doi.org/10.4103/MJDRDYPU.MJDRDYPU_294_16","url":null,"abstract":"Melanoma of mucosal sites is rare and is extremely rare in esophagus. Melanoma is known for its histological diversity mimicking any other malignancies with poor prognosis. Clinical presentation may be similar to other gastroesophageal junction malignancies with obstructive symptoms/bleeding with pigmented polypoid mass on endoscopy and gross examination. However, metastasis from elsewhere is to be considered in the absence of melanocytosis in the adjacent squamous epithelium. Immunohistochemistry with a panel of markers is necessary in amelanotic lesions, poorly differentiated morphology, and small biopsy specimens. We report a case of melanoma with plasmacytoid features in the gastroesophageal junction diagnosed in a small biopsy with immunohistochemical findings and follow-up esophagogastrectomy.","PeriodicalId":36033,"journal":{"name":"Medical Journal of Dr. D.Y. Patil University","volume":"10 1","pages":"585 - 588"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47803929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.4103/MJDRDYPU.MJDRDYPU_128_17
Sukhminder Jit Singh Bajwa, R. Haldar
{"title":"Anesthesia for cerebral palsy - Need for meticulous perioperative planning","authors":"Sukhminder Jit Singh Bajwa, R. Haldar","doi":"10.4103/MJDRDYPU.MJDRDYPU_128_17","DOIUrl":"https://doi.org/10.4103/MJDRDYPU.MJDRDYPU_128_17","url":null,"abstract":"","PeriodicalId":36033,"journal":{"name":"Medical Journal of Dr. D.Y. Patil University","volume":"10 1","pages":"602 - 604"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42505870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.4103/MJDRDYPU.MJDRDYPU_94_17
D. Mane, V. Satav, Ashwani Kandari, A. Mulay, V. Sabale, S. Kankalia
Aims: The aim is to study the clinical significance of urodynamics study (UDS) in patients of benign prostatic hyperplasia (BPH), with and without diabetes mellitus (DM) and to predict the outcome of surgical depending on UDS findings. Materials and Methods: A total of 120 BPH patients were studied and divided into two groups, BPH with DM and without DM. Initial evaluation, diagnostic tests, and urodynamic examination were done in all patients, and results were statistically analyzed. Results: There was no significant difference of age and prostate volume in both groups (P > 0.05), but there was a significant increase in symptom score in patients of BPH associated with DM (P < 0.05). Bladder outlet obstruction (BOO) was found in majority of patients in our groups (96.66%) with good detrusor function. Out of 120 patients, 6 patients (2 patient in BPH group and 4 patients in BPH with DM group) had detrusor underactivity (DU). There was a significant difference in the International Prostate Symptom Score, quality of life, peak flow rate, and postvoid residual urine, pre- to post-operatively in each group (P < 0.05). Out of the 6 patients who had DU, 4 patients (1 patient in BPH group and 3 patients in BPH with DM group) showed improvement in their flow rate and symptom score. Conclusion: DM in cases of BPH patients is not the prominent factor in deciding surgical treatment. It is the severity of BOO which determines the treatment and its outcome. UDS is an invasive and costly test and does not appear to be mandatory in clinically significant BPH even if associated with DM.
{"title":"Does urodynamics study help in evaluation and prognosis of treatment in benign prostatic hyperplasia with diabetes mellitus?","authors":"D. Mane, V. Satav, Ashwani Kandari, A. Mulay, V. Sabale, S. Kankalia","doi":"10.4103/MJDRDYPU.MJDRDYPU_94_17","DOIUrl":"https://doi.org/10.4103/MJDRDYPU.MJDRDYPU_94_17","url":null,"abstract":"Aims: The aim is to study the clinical significance of urodynamics study (UDS) in patients of benign prostatic hyperplasia (BPH), with and without diabetes mellitus (DM) and to predict the outcome of surgical depending on UDS findings. Materials and Methods: A total of 120 BPH patients were studied and divided into two groups, BPH with DM and without DM. Initial evaluation, diagnostic tests, and urodynamic examination were done in all patients, and results were statistically analyzed. Results: There was no significant difference of age and prostate volume in both groups (P > 0.05), but there was a significant increase in symptom score in patients of BPH associated with DM (P < 0.05). Bladder outlet obstruction (BOO) was found in majority of patients in our groups (96.66%) with good detrusor function. Out of 120 patients, 6 patients (2 patient in BPH group and 4 patients in BPH with DM group) had detrusor underactivity (DU). There was a significant difference in the International Prostate Symptom Score, quality of life, peak flow rate, and postvoid residual urine, pre- to post-operatively in each group (P < 0.05). Out of the 6 patients who had DU, 4 patients (1 patient in BPH group and 3 patients in BPH with DM group) showed improvement in their flow rate and symptom score. Conclusion: DM in cases of BPH patients is not the prominent factor in deciding surgical treatment. It is the severity of BOO which determines the treatment and its outcome. UDS is an invasive and costly test and does not appear to be mandatory in clinically significant BPH even if associated with DM.","PeriodicalId":36033,"journal":{"name":"Medical Journal of Dr. D.Y. Patil University","volume":"10 1","pages":"555 - 560"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41845235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.4103/MJDRDYPU.MJDRDYPU_160_17
Devendra Jain
{"title":"Does urodynamics study help in evaluation and prognosis of treatment in benign prostatic hyperplasia with diabetes mellitus?","authors":"Devendra Jain","doi":"10.4103/MJDRDYPU.MJDRDYPU_160_17","DOIUrl":"https://doi.org/10.4103/MJDRDYPU.MJDRDYPU_160_17","url":null,"abstract":"","PeriodicalId":36033,"journal":{"name":"Medical Journal of Dr. D.Y. Patil University","volume":"10 1","pages":"561 - 561"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43544242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.4103/MJDRDYPU.MJDRDYPU_2_17
Mridula Dua, Bhoomi G. Raval, S. Nasreen, V. R. Chari
Thoracic epidural anesthesia with ipsilateral brachial plexus block is emerging as an alternative to general anesthesia for oncologic breast surgery.1. A 31 year old, pneumonectomised female with a past history of MDR TB was diagnosed with infiltrating ductal carcinoma in left breast 2 months ago and was posted for MRM. She also had moderate Pulmonary Arterial Hypertension. Thoracic epidural anesthesia was induced with 12 ml of 0.5% Ropivacaine at T6-T7 level. Interscalene block was given with 10 ml 0.5% Ropivacaine using peripheral nerve locator. Patient was comfortable throughout the procedure and remained vitally stable. Post-operative analgesia was given with 10 ml of 0.2% ropivacaine and patient was discharged the following week. Thoracic epidural anesthesia provides the advantage of superior intra and post-operative analgesia without the adverse effects of general anesthesia like postoperative nausea, vomiting, respiratory depression and sedation.2 Coupled with interscalene block for axillary lymph node dissection, it can be successfully used as an alternative to GA for MRM.
{"title":"Thoracic epidural anesthesia and interscalene block for a pneumonectomized patient posted for modified radical mastectomy","authors":"Mridula Dua, Bhoomi G. Raval, S. Nasreen, V. R. Chari","doi":"10.4103/MJDRDYPU.MJDRDYPU_2_17","DOIUrl":"https://doi.org/10.4103/MJDRDYPU.MJDRDYPU_2_17","url":null,"abstract":"Thoracic epidural anesthesia with ipsilateral brachial plexus block is emerging as an alternative to general anesthesia for oncologic breast surgery.1. A 31 year old, pneumonectomised female with a past history of MDR TB was diagnosed with infiltrating ductal carcinoma in left breast 2 months ago and was posted for MRM. She also had moderate Pulmonary Arterial Hypertension. Thoracic epidural anesthesia was induced with 12 ml of 0.5% Ropivacaine at T6-T7 level. Interscalene block was given with 10 ml 0.5% Ropivacaine using peripheral nerve locator. Patient was comfortable throughout the procedure and remained vitally stable. Post-operative analgesia was given with 10 ml of 0.2% ropivacaine and patient was discharged the following week. Thoracic epidural anesthesia provides the advantage of superior intra and post-operative analgesia without the adverse effects of general anesthesia like postoperative nausea, vomiting, respiratory depression and sedation.2 Coupled with interscalene block for axillary lymph node dissection, it can be successfully used as an alternative to GA for MRM.","PeriodicalId":36033,"journal":{"name":"Medical Journal of Dr. D.Y. Patil University","volume":"10 1","pages":"605 - 607"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41385644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.4103/MJDRDYPU.MJDRDYPU_82_17
S. Chandanwale, N. Gupta, J. Sheth, Piyusha Naragude, A. Gambhir, Pooja Pathak, J. Nizam
Background and Objectives: Portal hypertensive gastropathy (PHG) refers to changes in the mucosa of the stomach in patients with portal hypertension. The diagnosis of PHG is usually made on endoscopy. It is clinically important because it may cause acute massive or insidious blood loss. We present a comprehensive study to ascertain the utility of gastric biopsy in identifying and assessing the presence and degree of pathological changes associated with PHG. Materials and Methods: Histological features of 30 gastric biopsies each from antrum and body of patients of portal hypertension with or without gastric symptoms were studied. They were grouped as Group A patients. Similarly, the histological features of 30 gastric biopsies each from antrum and body of patients of gastritis without portal hypertension were studied and were grouped as Group B patients. The biopsies were studied for mucosal changes such as edema in lamina propria, degree of inflammation, smooth muscle hyperplasia, collagen deposition, foveolar hyperplasia, intestinal metaplasia, presence of Helicobacter pylori, and fibrin thrombi. Results: Most common cause of portal hypertensive gastropathy was alcoholic liver cirrhosis. Histological features such as dilated congested capillaries, edema, extravasated red blood cell (RBC), and smooth muscle hyperplasia are more commonly seen in PHG (Group A) than gastritis (Group B) patients without portal hypertension. Conclusion: Alcoholic cirrhosis is a common cause of PHG. Dilated congested capillaries, edema, extravasated RBC, and smooth muscle hyperplasia are frequently seen in gastric biopsies of PHG patients than gastritis patients. These features are nonspecific.
{"title":"Histopathological study of portal hypertensive gastropathy using gastric biopsy","authors":"S. Chandanwale, N. Gupta, J. Sheth, Piyusha Naragude, A. Gambhir, Pooja Pathak, J. Nizam","doi":"10.4103/MJDRDYPU.MJDRDYPU_82_17","DOIUrl":"https://doi.org/10.4103/MJDRDYPU.MJDRDYPU_82_17","url":null,"abstract":"Background and Objectives: Portal hypertensive gastropathy (PHG) refers to changes in the mucosa of the stomach in patients with portal hypertension. The diagnosis of PHG is usually made on endoscopy. It is clinically important because it may cause acute massive or insidious blood loss. We present a comprehensive study to ascertain the utility of gastric biopsy in identifying and assessing the presence and degree of pathological changes associated with PHG. Materials and Methods: Histological features of 30 gastric biopsies each from antrum and body of patients of portal hypertension with or without gastric symptoms were studied. They were grouped as Group A patients. Similarly, the histological features of 30 gastric biopsies each from antrum and body of patients of gastritis without portal hypertension were studied and were grouped as Group B patients. The biopsies were studied for mucosal changes such as edema in lamina propria, degree of inflammation, smooth muscle hyperplasia, collagen deposition, foveolar hyperplasia, intestinal metaplasia, presence of Helicobacter pylori, and fibrin thrombi. Results: Most common cause of portal hypertensive gastropathy was alcoholic liver cirrhosis. Histological features such as dilated congested capillaries, edema, extravasated red blood cell (RBC), and smooth muscle hyperplasia are more commonly seen in PHG (Group A) than gastritis (Group B) patients without portal hypertension. Conclusion: Alcoholic cirrhosis is a common cause of PHG. Dilated congested capillaries, edema, extravasated RBC, and smooth muscle hyperplasia are frequently seen in gastric biopsies of PHG patients than gastritis patients. These features are nonspecific.","PeriodicalId":36033,"journal":{"name":"Medical Journal of Dr. D.Y. Patil University","volume":"10 1","pages":"562 - 567"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49134814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.4103/MJDRDYPU.MJDRDYPU_61_17
Sumeet Bhatt, G. Rajesh, D. Thakur
Objectives: An act of bioterrorism may compromise the local medical system and require whole of the healthcare workforce. The purpose of the present study was to assess the knowledge, perceived need for education, and willingness to participate in bioterrorism management among students in an Indian dental institute. Materials and Methods: A total of 231 dental students, including undergraduates and postgraduates, participated in this study conducted in the year 2014. Dental students' knowledge, perceived need, and willingness were assessed using a self-administered questionnaire. Results: More than 90% of both undergraduate and postgraduate students were willing to provide care during a bioterrorism attack. The actual knowledge was observed to be very low in both groups. Perceived knowledge as well as actual knowledge was statistically higher in the postgraduate group (P < 0.05). Most of the participants were of the opinion that they need more education regarding bioterrorism and that it should be added to dental curriculum. The majority of the participants showed willingness to attend continuing education programs on bioterrorism. Conclusions: The dental students demonstrated low knowledge but high willingness to provide care. A policy-driven approach to include bioterrorism management in dental education and organization of more continuing education programs is recommended to improve knowledge and develop necessary skills. This will help develop a workforce efficient in providing care during a possible act of bioterrorism.
{"title":"Knowledge, perceived need for education, and willingness to participate in bioterrorism preparedness among students in an indian dental institute: A questionnaire study","authors":"Sumeet Bhatt, G. Rajesh, D. Thakur","doi":"10.4103/MJDRDYPU.MJDRDYPU_61_17","DOIUrl":"https://doi.org/10.4103/MJDRDYPU.MJDRDYPU_61_17","url":null,"abstract":"Objectives: An act of bioterrorism may compromise the local medical system and require whole of the healthcare workforce. The purpose of the present study was to assess the knowledge, perceived need for education, and willingness to participate in bioterrorism management among students in an Indian dental institute. Materials and Methods: A total of 231 dental students, including undergraduates and postgraduates, participated in this study conducted in the year 2014. Dental students' knowledge, perceived need, and willingness were assessed using a self-administered questionnaire. Results: More than 90% of both undergraduate and postgraduate students were willing to provide care during a bioterrorism attack. The actual knowledge was observed to be very low in both groups. Perceived knowledge as well as actual knowledge was statistically higher in the postgraduate group (P < 0.05). Most of the participants were of the opinion that they need more education regarding bioterrorism and that it should be added to dental curriculum. The majority of the participants showed willingness to attend continuing education programs on bioterrorism. Conclusions: The dental students demonstrated low knowledge but high willingness to provide care. A policy-driven approach to include bioterrorism management in dental education and organization of more continuing education programs is recommended to improve knowledge and develop necessary skills. This will help develop a workforce efficient in providing care during a possible act of bioterrorism.","PeriodicalId":36033,"journal":{"name":"Medical Journal of Dr. D.Y. Patil University","volume":"10 1","pages":"526 - 531"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43206673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-09-01DOI: 10.4103/0975-2870.218182
R. Ravikanth, M. Abraham, Ashok Alapati
Sickle cell anemia is an inherited hemoglobin disorder characterized by substitution of glutamic acid by valine at the sixth position of the beta globin chain. The sequence of events leads to pain crisis. Ischemia of the tissues resulting from decreased blood flow is believed to occur in pain crisis. Repeated or prolonged sickling causes red cell death in the form of hemolytic anemia. The majority of hospital admissions are due to painful crisis. These patients are at increased risk for both osteomyelitis and infarction of the long bones. Magnetic resonance imaging has been shown to be helpful in the diagnosis of early osteomyelitis and its differentiation from infarction in sickle cell disease patients with acute bone crisis. Others findings include dactylitis, medullary infarcts, diploic space widening, fish mouth vertebrae, and avascular necrosis. We present a case series on the various musculoskeletal manifestations of sickle cell disease.
{"title":"Musculoskeletal manifestations in sickle cell anemia","authors":"R. Ravikanth, M. Abraham, Ashok Alapati","doi":"10.4103/0975-2870.218182","DOIUrl":"https://doi.org/10.4103/0975-2870.218182","url":null,"abstract":"Sickle cell anemia is an inherited hemoglobin disorder characterized by substitution of glutamic acid by valine at the sixth position of the beta globin chain. The sequence of events leads to pain crisis. Ischemia of the tissues resulting from decreased blood flow is believed to occur in pain crisis. Repeated or prolonged sickling causes red cell death in the form of hemolytic anemia. The majority of hospital admissions are due to painful crisis. These patients are at increased risk for both osteomyelitis and infarction of the long bones. Magnetic resonance imaging has been shown to be helpful in the diagnosis of early osteomyelitis and its differentiation from infarction in sickle cell disease patients with acute bone crisis. Others findings include dactylitis, medullary infarcts, diploic space widening, fish mouth vertebrae, and avascular necrosis. We present a case series on the various musculoskeletal manifestations of sickle cell disease.","PeriodicalId":36033,"journal":{"name":"Medical Journal of Dr. D.Y. Patil University","volume":"10 1","pages":"453"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45669378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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