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Phenytoin-induced changes in the bone mineral metabolism in young males 苯妥英引起的年轻男性骨矿物质代谢的变化
Q4 Medicine Pub Date : 2017-09-01 DOI: 10.4103/MJDRDYPU.MJDRDYPU_56_17
S. Rohatgi, A. Ahluwalia
Background: Antiepileptic drugs (AEDs) have an adverse effect on the bone mineral metabolism. Patients and Methods: The objective of the study was to determine the bone loss and change in bone mineral parameters in patients treated with phenytoin sodium. We prospectively studied 36 young males aged 20–30 years, with new-onset epilepsy, and treated with phenytoin. Patients were clinically examined and subjected to determination of the bone mineral density (BMD) by dual-energy X-ray absorptiometry (DXA) at the femur neck, spine, and lower third of radius. We also assessed Vitamin 25-OH-Vitamin D3, parathyroid hormone (PTH), and osteocalcin at the onset and after 1 year of treatment. Results: There were no significant changes noted in the 25-OH-Vitamin D3, (20.7 ± 10 ng/dl before and 18.5 ± 7.3 ng/dl after therapy, P = 0.198), and serum parathyroid levels (8.8 ± 6.8 pg/ml before and 14.2 ± 11.5 pg/ml, P = 0.114) at the end of 1-year therapy. There was declines in BMD at all the three sites; the spine (0.943 ± 0.11 vs. 0.943 ± 0.12 g/cm2, P = 0.15), femur neck (0.912 ± 0.0.12 vs. 0.896 ± 0.124 g/cm2, P = 0.093), and a statistically significant decline lower third of radius (0.659 ± 0.07 vs. 0.644 ± 0.073 g/cm2, P ≤ 0.001). We did not find any significant change in levels of 25-OH-Vitamin D3, PTH, and serum alkaline phosphatase, but found significant elevation in levels of osteocalcin. Conclusions: Phenytoin therapy in young male patients for 1-year causes a bone loss at femur and spine in the absence of Vitamin D deficiency and significant bone loss in the cortical bone radius. DXA should be done in patients during the treatment with AEDs to identify patients who are susceptible to increased risk of fractures.
背景:抗癫痫药物对骨矿物质代谢有不良影响。患者和方法:本研究的目的是测定苯妥英钠治疗患者的骨丢失和骨矿物质参数的变化。我们前瞻性研究了36名20-30岁的新发癫痫年轻男性,并用苯妥英钠治疗。对患者进行临床检查,并通过双能X射线吸收仪(DXA)测定股骨颈、脊椎和桡骨下三分之一处的骨密度(BMD)。我们还评估了治疗开始时和治疗1年后的维生素25-OH、维生素D3、甲状旁腺激素(PTH)和骨钙素。结果:在1年治疗结束时,25-OH维生素D3(治疗前20.7±10ng/ml,治疗后18.5±7.3ng/ml,P=0.198)和血清甲状旁腺水平(治疗前8.8±6.8pg/ml,治疗后14.2±11.5pg/ml,P=0.114)没有显著变化。三个部位的骨密度均有下降;脊柱(0.943±0.11 vs.0.943±0.12 g/cm2,P=0.15)、股骨颈(0.912±0.0.12 vs.0.896±0.124 g/cm2,P=0.093)和桡骨下三分之一的统计学显著下降(0.659±0.07 vs.0.644±0.073 g/cm2,P≤0.001)。我们没有发现25-OH维生素D3、PTH和血清碱性磷酸酶的水平有任何显著变化,但发现骨钙素水平显著升高。结论:在没有维生素D缺乏的情况下,对年轻男性患者进行为期1年的苯妥英钠治疗会导致股骨和脊椎骨丢失,并导致桡骨皮质骨显著丢失。在AED治疗期间,应对患者进行DXA,以确定易发生骨折风险增加的患者。
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引用次数: 0
Gastrointestinal stromal tumor of the anal canal: An unusual presentation 肛管胃肠道间质瘤:一种不寻常的表现
Q4 Medicine Pub Date : 2017-09-01 DOI: 10.4103/MJDRDYPU.MJDRDYPU_293_16
C. Das, M. Mukhopadhyay, M. Kumari, Bikram Halder
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasm of the gastrointestinal tract. The most common site is stomach, followed by small intestine, colon, and esophagus. However, GIST from the anal canal is an extremely rare tumor. Here, we report an extremely rare case of GIST of the anal canal in a 40-year-old female with a history of irregular bowel habits mixed with blood and constipation for 4 months. Diagnosis was made on the basis of histopathological and immunohistochemical examination.
胃肠道间质瘤(gist)是最常见的胃肠道间质肿瘤。最常见的部位是胃,其次是小肠、结肠和食道。然而,来自肛管的GIST是一种极其罕见的肿瘤。在此,我们报告一例极其罕见的肛管间质瘤病例,患者为40岁女性,排便习惯不规则,伴血和便秘4个月。经组织病理学和免疫组织化学检查诊断。
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引用次数: 1
Aggressive angiomyxoma of scrotum in a young male: A rare entity 年轻男性阴囊侵袭性血管粘液瘤:罕见病例
Q4 Medicine Pub Date : 2017-09-01 DOI: 10.4103/MJDRDYPU.MJDRDYPU_297_16
K. Tadepalli, Vijaya Gattu
Aggressive angiomyxoma (AAM) is a rare mesenchymal benign myxoid tumor of the pelvis and perineum which occurs almost exclusively in adult females. It rarely occurs in males and involves scrotum. Here, we report a case of aggressive angiomyxoma in a 15-year-old male presented with a slow-growing scrotal swelling for 6 months. About 150 cases were reported worldwide (few cases were reported in males). AAM in the scrotal region may present as a scrotal mass, often mistaken for a hernia or hydrocele.
侵袭性血管黏液瘤(AAM)是一种罕见的骨盆和会阴间充质良性黏液样肿瘤,几乎只发生在成年女性身上。它很少发生在男性身上,涉及阴囊。在此,我们报告了一例侵袭性血管黏液瘤的病例,该病例发生在一名15岁男性身上,其阴囊肿胀缓慢,持续6个月。全世界报告了大约150例病例(很少有男性病例报告)。阴囊区域的AAM可能表现为阴囊肿块,通常被误认为是疝或鞘膜积液。
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引用次数: 0
Chloroma in a child with T-cell acute lymphoblastic leukemia 儿童T细胞急性淋巴细胞白血病的绿瘤
Q4 Medicine Pub Date : 2017-09-01 DOI: 10.4103/MJDRDYPU.MJDRDYPU_7_17
A. Mandal, Amitabh Singh, Vijay Gnanaguru, R. Seth
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引用次数: 0
Unilateral multicystic dysplastic kidney with ipsilateral grade V vesicoureteral reflux: A case report of a rare association 单侧多囊发育不良肾伴同侧V级膀胱输尿管反流1例
Q4 Medicine Pub Date : 2017-09-01 DOI: 10.4103/0975-2870.218185
S. Agarwal, B. Badhe, P. Pandey, M. Ralli
Multicystic renal dysplasia is a common cause of childhood end-stage renal failure and is categorized under the entity known as congenital anomalies of kidney and urinary tract. With the increasing knowledge about their natural history, it is now known that most of the cases of unilateral multicystic dysplastic kidney undergo spontaneous involution; thus, most of the pediatric urologists now prefer conservative management with long-term nephrological and urological observation. However, the presence of recurrent urinary tract infection as in the present case report due to associated ipsilateral Grade V vesicoureteral reflux, a rare associated finding mandates nephrectomy.
多囊肾发育不良是儿童终末期肾功能衰竭的常见原因,被归类为肾脏和泌尿道先天性异常。随着对其自然史的了解不断增加,现在知道大多数单侧多囊性发育不良肾的病例是自发复发;因此,大多数儿科泌尿科医生现在倾向于保守治疗,并长期观察肾脏和泌尿科。然而,在本病例报告中,由于相关的同侧V级膀胱输尿管反流而出现复发性尿路感染,这是一种罕见的相关发现,需要进行肾脏切除术。
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引用次数: 1
Nanotechnology for health: A new useful technology in medicine 纳米技术促进健康:医学上一项有用的新技术
Q4 Medicine Pub Date : 2017-09-01 DOI: 10.4103/MJDRDYPU.MJDRDYPU_32_17
B. Joob, V. Wiwanitkit
Nanotechnology is accepted as a very useful new technology at present. The impact of new nanotechnology on health is very interesting. Indeed, several usefulness of nanotechnology on animal and human health can be expected. On the other hand, the negative effect of nanotechnology can also be seen. The applied nanotechnologies in public health and medicine already exist. In this short article, the summarization and discussion on nanotechnology and health are presented. It can be seen that the nanotechnology can be applicable in several fields of medicine and can help practitioner in diagnostic, therapeutic, and preventive activities.
纳米技术是目前公认的一项非常有用的新技术。新的纳米技术对健康的影响非常有趣。事实上,纳米技术在动物和人类健康方面的一些有用性是可以预期的。另一方面,纳米技术的负面影响也可见一斑。纳米技术在公共卫生和医学领域的应用已经存在。在这篇短文中,对纳米技术和健康进行了总结和讨论。可以看出,纳米技术可以应用于医学的几个领域,并可以帮助从业者进行诊断、治疗和预防活动。
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引用次数: 12
Measles outbreak in adults: A changing epidemiological pattern 成人麻疹暴发:不断变化的流行病学模式
Q4 Medicine Pub Date : 2017-09-01 DOI: 10.4103/MJDRDYPU.MJDRDYPU_43_17
S. Bajaj, Pranjal Bobdey, Neha Singh
Background: Thirty-one cases of fever with rash were reported among students of a college in Pune, India, from March to May 2014. The clinical profile was similar to that of measles and 7 of them tested positive for measles-specific immunoglobulin M (IgM). An outbreak of measles was declared, and epidemiological investigation was carried out to assess the situation and suggest preventive measures. Methods: An epidemiological case sheet filled for each case to identify the source and likely contacts. Medical and administrative authorities were sensitized about the increase in incidence and clustering of cases. A surveillance system was set up for detection of new cases and follow-up of contacts. Throat swabs and blood samples from 12 cases were tested by ELISA method for commonly occurring viral exanthematous fevers to confirm the diagnosis and 7 were positive for measles-specific IgM antibody. Preventive measures were advised to control the outbreak. Results: A total of 31 cases of fever with rashes were reported among students of a college in Pune, India, during the months of March–May 2014. Most of the students were in the age group of 18–24 years. Samples from 12 cases were sent for testing and 7 tested positive for measles-specific IgM antibodies. Seven cases were epidemiologically linked to a lab-confirmed case. All cases had fever, maculopapular rash, and sore throat and gave a history of vaccination for measles in childhood. Conclusion: An epidemiological investigation was carried out for outbreak of measles in a young adult population of college students from Pune. It is reported that, with increase in overall coverage of vaccination, there is a rise in incidence of measles in vaccinated individuals. The age profile also shifts to higher age groups. Investigation of such outbreaks provides an opportunity to identify high-risk groups, changes in measles epidemiology and weaknesses in the routine immunization programs.
背景:2014年3月至5月,印度浦那一所大学的学生中报告了31例发烧伴皮疹的病例。临床特征与麻疹相似,其中7人的麻疹特异性免疫球蛋白M(IgM)检测呈阳性。宣布爆发麻疹,并进行了流行病学调查,以评估情况并提出预防措施。方法:为每个病例填写流行病学病例表,以确定来源和可能的接触者。医疗和行政当局对病例发生率和聚集性的增加提高了认识。建立了一个监测系统,用于发现新病例和追踪接触者。采用ELISA法对12例患者的咽拭子和血液样本进行了常见病毒性发疹性发热的检测,以确认诊断,7例患者的麻疹特异性IgM抗体呈阳性。建议采取预防措施控制疫情。结果:2014年3月至5月,印度浦那一所大学的学生中共报告了31例发烧伴皮疹的病例。大多数学生年龄在18-24岁之间。12个病例的样本被送往检测,7个病例的麻疹特异性IgM抗体检测呈阳性。7例病例与实验室确诊病例有流行病学联系。所有病例都有发烧、斑丘疹和喉咙痛,并有儿童麻疹疫苗接种史。结论:对浦那市青年大学生麻疹疫情进行了流行病学调查。据报道,随着疫苗接种总覆盖率的提高,接种疫苗的人的麻疹发病率也在上升。年龄分布也向更高年龄组转移。对此类疫情的调查为确定高危人群、麻疹流行病学的变化和常规免疫计划的薄弱环节提供了机会。
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引用次数: 9
Giant brenner tumor of ovary 卵巢巨大布伦纳瘤
Q4 Medicine Pub Date : 2017-09-01 DOI: 10.4103/MJDRDYPU.MJDRDYPU_261_16
Rupali R. Bavikar, S. Bamanikar, H. Kumar, M. Jha, Y. Ingale
Brenner tumor is a rare ovarian tumor that is a part of the surface epithelial group of ovarian neoplasm. It is usually asymptomatic, and most of the times, it is an incidental pathological finding. They can be subdivided into benign, borderline or proliferative, and malignant neoplasms. The majority of Brenner tumors are benign in nature. Tumors of borderline malignancy are less frequent, and only about 1% of tumors are borderline. Here, we present a rare case of giant Brenner tumor of ovary measuring 28 cm in diameter. This is the case is presented because the giant size of Brenner tumor, although rare gynecologist should be aware of this rare entity.
布伦纳肿瘤是一种罕见的卵巢肿瘤,是卵巢肿瘤表面上皮组的一部分。它通常是无症状的,大多数时候,它是偶然的病理学发现。它们可以细分为良性、交界性或增殖性肿瘤和恶性肿瘤。大多数布伦纳肿瘤本质上是良性的。边缘恶性肿瘤的发生率较低,只有约1%的肿瘤处于边缘。在此,我们报告了一个罕见的卵巢巨大布伦纳肿瘤,直径28厘米。之所以出现这种情况,是因为巨大的布伦纳肿瘤,尽管罕见的妇科医生应该意识到这种罕见的实体。
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引用次数: 0
Quantification of vulnerability to Type 2 diabetes: A study among shopkeepers in Kolkata 2型糖尿病易感性的量化:加尔各答店主的研究
Q4 Medicine Pub Date : 2017-09-01 DOI: 10.4103/MJDRDYPU.MJDRDYPU_63_17
A. Dasgupta, B. Biswas, B. Paul, L. Bandyopadhyay, Ayon Ghosh, Sembagamuthu Sembiah
Context: Urban people are more prone to develop diabetes due to their sedentary lifestyle and high-calorie food intake. Shopkeepers with their long sitting hours, unhealthy food habits, and lack of regular physical activity are one of the high-risk groups for developing diabetes. Hence, it is necessary to detect this large pool of undiagnosed people with diabetes to offer them early treatment. Aims: The present study aimed at assessing people with a high risk of developing type 2 diabetes and its correlation with some known risk factors. Materials and Methods: The study was a cross-sectional community-based study conducted from May to July among 152 shopkeepers in a permanent market with a structured schedule. Statistical Analysis Used: Data were analyzed using appropriate statistical methods by SPSS software (version 16). Results: Thirty-five (23.02%) out of 152 shopkeepers were found having high blood sugar (>140 mg/dl). In univariate analysis, the study participants with higher age, perceived stress score, Indian Diabetic Risk Score (IDRS), body weight, centrally obese, and less physically active had shown significantly greater odds of having high blood sugar level. In multivariable model, PSS (adjusted odds ratio [AOR]-1.90), waist circumference (AOR-3.34), and physical activity (AOR-3.09) remained significantly adjusted with other significant variables in univariate analysis excepting IDRS. Sensitivity and specificity of IDRS were 68.6% and 65.8%, respectively, with diagnostic accuracy of 72.3% calculated using receiver operating characteristic curve. Conclusions: The study revealed that shopkeepers are indeed at high risk of developing diabetes. There is an urgent need for increasing awareness regarding diabetes among them.
背景:由于久坐的生活方式和高热量的食物摄入,城市人更容易患糖尿病。店主久坐、不健康的饮食习惯和缺乏规律的体育活动是患糖尿病的高危人群之一。因此,有必要发现大量未确诊的糖尿病患者,为他们提供早期治疗。目的:本研究旨在评估2型糖尿病高危人群及其与一些已知风险因素的相关性。材料和方法:这项研究是一项基于社区的横断面研究,于5月至7月在一个固定市场的152名店主中进行,并制定了结构化的时间表。使用的统计分析:使用SPSS软件(版本16),使用适当的统计方法对数据进行分析。结果:152名店主中有35名(23.02%)患有高血糖(>140mg/dl)。在单变量分析中,年龄、感知压力评分、印度糖尿病风险评分(IDRS)、体重、中心性肥胖和体力活动较少的研究参与者出现高血糖水平的几率明显更大。在多变量模型中,PSS(调整比值比[AOR]-1.90)、腰围(AOR-3.34)和体力活动(AOR-3.09)在单变量分析中与除IDRS外的其他显著变量保持显著调整。IDRS的敏感性和特异性分别为68.6%和65.8%,使用受试者操作特征曲线计算的诊断准确率为72.3%。结论:研究表明,店主患糖尿病的风险确实很高。迫切需要提高他们对糖尿病的认识。
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引用次数: 1
Uterine intramural lipoma: A benign but rare entity 子宫壁内脂肪瘤:一种少见的良性肿瘤
Q4 Medicine Pub Date : 2017-07-01 DOI: 10.4103/0975-2870.213931
V. Pathak, Deepti Sukheeja, Rakesh K. Singh
Lipoma of the uterus is a rare benign tumor, usually developing in postmenopausal woman. Clinical symptoms and physical signs are similar to those found in leiomyomas. Most are postoperative chance finding following hysterectomy for leiomyoma. A 50-year-old postmenopausal woman presented with vaginal prolapse. The hysterectomy specimen showed an intramural lipoma of the uterus. The diagnosis of pure lipoma of the uterus should be made when any smooth muscle if present is confined to the periphery of the tumor composing of mature adipocytes. Our case highlights the importance of this benign but rare entity.
子宫脂肪瘤是一种罕见的良性肿瘤,通常发生在绝经后妇女。临床症状和体征与平滑肌瘤相似。大多数是平滑肌瘤子宫切除术后的术后偶然发现。一个50岁的绝经后妇女提出阴道脱垂。子宫切除术标本显示子宫壁内脂肪瘤。纯子宫脂肪瘤的诊断应在任何平滑肌(如果存在)局限于由成熟脂肪细胞组成的肿瘤周围时作出。我们的病例突出了这种良性但罕见的实体的重要性。
{"title":"Uterine intramural lipoma: A benign but rare entity","authors":"V. Pathak, Deepti Sukheeja, Rakesh K. Singh","doi":"10.4103/0975-2870.213931","DOIUrl":"https://doi.org/10.4103/0975-2870.213931","url":null,"abstract":"Lipoma of the uterus is a rare benign tumor, usually developing in postmenopausal woman. Clinical symptoms and physical signs are similar to those found in leiomyomas. Most are postoperative chance finding following hysterectomy for leiomyoma. A 50-year-old postmenopausal woman presented with vaginal prolapse. The hysterectomy specimen showed an intramural lipoma of the uterus. The diagnosis of pure lipoma of the uterus should be made when any smooth muscle if present is confined to the periphery of the tumor composing of mature adipocytes. Our case highlights the importance of this benign but rare entity.","PeriodicalId":36033,"journal":{"name":"Medical Journal of Dr. D.Y. Patil University","volume":"10 1","pages":"384"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42430700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
期刊
Medical Journal of Dr. D.Y. Patil University
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