Pub Date : 2023-07-02DOI: 10.31117/neuroscirn.v6i3.185
M. Le, T. Tran, Nghia Minh Tran, Bao Lam Thai Tran, Thang Nguyen
Epidural steroid injections (ESIs) have been mentioned by international medical literature as an option for treatment and pain relief for patients with lumbar disc herniation (LDH). Several studies worldwide have recognized the efficacy of treating LDH with ESIs to be between 72-86%. Our study aimed to elucidate the ESIs technique's effectiveness, advantages, and disadvantages. A 30-day pre-post study in 100 LDH patients underwent the ESIs technique. Patients meeting the criteria received physical examinations and magnetic resonance imaging (MRI) scans before undergoing the method. The Visual Analog Scale (VAS) was applied to assess the patient's hospitalization condition after ESIs 1 day, 7 days, and 30 days. After 1 day of ESIs, 85% of patients responded well (10% excellent and 75% moderate), and this prevalence increased up to 95% after 7 days and 30 of follow-up. The ESIs safety assessment after 1 day of treatment recorded that 2% of patients had complications and 24% had medication side effects. After 7 days, 4% of patients had epigastric pain and no more complications. Treatment outcomes of ESIs were effective and high safety in patients with LDH.
{"title":"Application of epidural steroid injection for the treatment of lumbar disc herniation in Vietnam","authors":"M. Le, T. Tran, Nghia Minh Tran, Bao Lam Thai Tran, Thang Nguyen","doi":"10.31117/neuroscirn.v6i3.185","DOIUrl":"https://doi.org/10.31117/neuroscirn.v6i3.185","url":null,"abstract":"Epidural steroid injections (ESIs) have been mentioned by international medical literature as an option for treatment and pain relief for patients with lumbar disc herniation (LDH). Several studies worldwide have recognized the efficacy of treating LDH with ESIs to be between 72-86%. Our study aimed to elucidate the ESIs technique's effectiveness, advantages, and disadvantages. A 30-day pre-post study in 100 LDH patients underwent the ESIs technique. Patients meeting the criteria received physical examinations and magnetic resonance imaging (MRI) scans before undergoing the method. The Visual Analog Scale (VAS) was applied to assess the patient's hospitalization condition after ESIs 1 day, 7 days, and 30 days. After 1 day of ESIs, 85% of patients responded well (10% excellent and 75% moderate), and this prevalence increased up to 95% after 7 days and 30 of follow-up. The ESIs safety assessment after 1 day of treatment recorded that 2% of patients had complications and 24% had medication side effects. After 7 days, 4% of patients had epigastric pain and no more complications. Treatment outcomes of ESIs were effective and high safety in patients with LDH.","PeriodicalId":36108,"journal":{"name":"Neuroscience Research Notes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47621000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Poor sleep quality is associated with decreased brain health, such as fatigue, low quality of life, and risk of neurological and psychiatric comorbidities. Until now, no testing instruments for an accurate assessment of sleep quality for use in the general population have been rigorously translated and validated in Mongolia. We aimed to determine the psychometric properties of the globally recognized screening tool and sleep quality in the general population of Mongolia. In this cross-sectional study, participants were randomly selected between August and October 2020, from 64 sites in 8 urban, and 9 rural areas in Mongolia. Of the total 1152 participants (mean age, SD=42.66±12.6, range: 18 and 65) 76% were women. An overall Cronbach’s α was 0.69. Both EFA and CFA indicated a two-factor solution. The PSQI total score was positively correlated with anxiety and depression. The PSQI total score (p values < 0.01) was negatively correlated with the mean scores of all domains of WHOQOL-BREF. The mean PSQI total score was 5.67±3.4 and 43% of the participants were classified as poor sleepers by a global cut-off point of 5. The Mongolian version of the PSQI demonstrated a reliable and valid tool for screening sleep quality among the Mongolian general population. The results suggest that the prevalence rate of poor sleep quality was 43% using PSQI global cut-off point.
{"title":"Psychometric properties of the Mongolian version of the Pittsburgh Sleep Quality Index","authors":"Enkhnaran Tumurbaatar, Tetsuya Hiramoto, Gantsetseg Tumur-Ochir, Enkhjin Bat-Erdene, Chimeddulam Erdenebaatar, Tsolmon Amartuvshin, Myagmartseren Dashtseren, Battuvshin Lkhagvasuren, Damdindorj Boldbaatar, Tsolmon Jadamba","doi":"10.31117/neuroscirn.v6i3.190","DOIUrl":"https://doi.org/10.31117/neuroscirn.v6i3.190","url":null,"abstract":"Poor sleep quality is associated with decreased brain health, such as fatigue, low quality of life, and risk of neurological and psychiatric comorbidities. Until now, no testing instruments for an accurate assessment of sleep quality for use in the general population have been rigorously translated and validated in Mongolia. We aimed to determine the psychometric properties of the globally recognized screening tool and sleep quality in the general population of Mongolia. In this cross-sectional study, participants were randomly selected between August and October 2020, from 64 sites in 8 urban, and 9 rural areas in Mongolia. Of the total 1152 participants (mean age, SD=42.66±12.6, range: 18 and 65) 76% were women. An overall Cronbach’s α was 0.69. Both EFA and CFA indicated a two-factor solution. The PSQI total score was positively correlated with anxiety and depression. The PSQI total score (p values < 0.01) was negatively correlated with the mean scores of all domains of WHOQOL-BREF. The mean PSQI total score was 5.67±3.4 and 43% of the participants were classified as poor sleepers by a global cut-off point of 5. The Mongolian version of the PSQI demonstrated a reliable and valid tool for screening sleep quality among the Mongolian general population. The results suggest that the prevalence rate of poor sleep quality was 43% using PSQI global cut-off point.","PeriodicalId":36108,"journal":{"name":"Neuroscience Research Notes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42230799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-25DOI: 10.31117/neuroscirn.v6i2.215
Wan Lei Thien, Chrystalle B. Y. Tan, K. L. Chin
Over 10% of the world population suffer from mental disorders. In particular, depression causes about 800,000 suicide cases annually, while anxiety is the most common mental disorder. Stresses from work, life, and health have been identified as the common triggers for the two mental disorders. Eventhough mental disorders are treatable and validated tools are available to diagnose, many individuals are left untreated due to different factors, such as a lack of trained personnel and stigma. Neuroscience research indicates that mental disorders could be hereditary, where genes involved in determining behavioural variants. Disturbance in brain communication, resulting from abnormalities in neurogenesis, neurotransmission, and enzymatic degradation, have led to negative emotional states. This mini-review will highlight some important genes in the neurotransmitter systems and explore the relationship between gene polymorphisms and emotional states (i.e., depression, anxiety, and stress). The genes that will be discussed in this mini-review include brain-derived neurotrophic factor (BDNF) which is involved in neuron development, serotonin-transporter-linked polymorphic region (5-HTTLPR) and 5-hydroxytryptamine receptor 1A (5-HT1A) which are involved in serotonin neurotransmitter action potential propagation, and monoamine oxidase A (MAOA) and catechol-O-methyltransferase (COMT), which are involved in neurotransmitter catabolism.
超过10%的世界人口患有精神障碍。特别是，抑郁症每年导致约80万例自杀，而焦虑是最常见的精神障碍。来自工作、生活和健康的压力已被确定为这两种精神障碍的常见诱因。尽管精神障碍是可以治疗的，而且有经过验证的诊断工具，但由于缺乏训练有素的人员和污名等不同因素，许多人没有得到治疗。神经科学研究表明，精神障碍可能是遗传的，其中基因参与决定行为变异。由神经发生、神经传递和酶降解异常引起的脑通讯障碍导致了消极的情绪状态。这篇综述将重点介绍神经递质系统中的一些重要基因，并探讨基因多态性与情绪状态(即抑郁、焦虑和压力)之间的关系。本文将讨论的基因包括参与神经元发育的脑源性神经营养因子(BDNF)、参与5-羟色胺转运蛋白相关多态区(5-HTTLPR)和5-羟色胺受体1A (5-HT1A)，以及参与神经递质分解代谢的单胺氧化酶A (MAOA)和儿茶酚- o -甲基转移酶(COMT)。
{"title":"Influences of neurotransmission-related genetic polymorphisms on depression, anxiety and stress","authors":"Wan Lei Thien, Chrystalle B. Y. Tan, K. L. Chin","doi":"10.31117/neuroscirn.v6i2.215","DOIUrl":"https://doi.org/10.31117/neuroscirn.v6i2.215","url":null,"abstract":"Over 10% of the world population suffer from mental disorders. In particular, depression causes about 800,000 suicide cases annually, while anxiety is the most common mental disorder. Stresses from work, life, and health have been identified as the common triggers for the two mental disorders. Eventhough mental disorders are treatable and validated tools are available to diagnose, many individuals are left untreated due to different factors, such as a lack of trained personnel and stigma. Neuroscience research indicates that mental disorders could be hereditary, where genes involved in determining behavioural variants. Disturbance in brain communication, resulting from abnormalities in neurogenesis, neurotransmission, and enzymatic degradation, have led to negative emotional states. This mini-review will highlight some important genes in the neurotransmitter systems and explore the relationship between gene polymorphisms and emotional states (i.e., depression, anxiety, and stress). The genes that will be discussed in this mini-review include brain-derived neurotrophic factor (BDNF) which is involved in neuron development, serotonin-transporter-linked polymorphic region (5-HTTLPR) and 5-hydroxytryptamine receptor 1A (5-HT1A) which are involved in serotonin neurotransmitter action potential propagation, and monoamine oxidase A (MAOA) and catechol-O-methyltransferase (COMT), which are involved in neurotransmitter catabolism.","PeriodicalId":36108,"journal":{"name":"Neuroscience Research Notes","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41326039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-29DOI: 10.31117/neuroscirn.v6i2.224
N. Gendendagva, Y. Sankhuu, Anar Bayarmunkh, B. Dagvajantsan, Altaisaikhan Khasag, Oyuntugs Byambasukh
According to the World Health Organization report in 2020, the number of stroke deaths in Mongolia has reached 4,401, accounting for 19.84% of the total deaths, ranking as the second leading cause of death in Mongolia. Furthermore, the prevalence of diabetes has been steadily increasing for the last 20 years. In this case-control study (80 diabetic and 160 non-diabetic subjects), we analyzed data from two tertiary stroke centers over the past six months (June-December 2022). Inclusion criteria included patients over 18 years who presented to the emergency department with an acute ischemic stroke (I63 according to ICD 10). We reviewed and compared the data on clinical assessments such as the National Institutes of Health The Stroke Scale (NIHTSS), Glasgow Coma Scale and Modified Rankin Score, laboratory parameters, and TOAST classification of ischemic stroke between diabetic and non-diabetic patients in Mongolia. The mean age was 39.2±15.2, and 33.2% (n = 392) were male. The duration of diabetes in patients ranged from 0 to 23 years, and the median was 5.0. Mean glycated haemoglobin in subjects was 9.75±2.49%, and only 27.5% (n = 22) had HbA1c below 7.5%. Only BMI was significantly different in patients with diabetes compared to patients without diabetes (27.2±4.4 vs. 28.6±5.2). However, for other parameters, no significant difference was observed, but the NIHTSS at discharge was significantly higher in patients with diabetes. According to the TOAST classification, the risk of ischemic stroke caused by microangiopathy (18% vs 33.8%, p=0.142) and macroangiopathy (44.4% vs 57.5%, p=0.192) was 13-15% higher in people with diabetes than in people without diabetes. In regression analysis, patients with diabetes had a six times greater risk of ischemic stroke caused by atherosclerosis than non-diabetic patients. Most subtypes of stroke that occur in people with diabetes are caused by atherosclerosis, both large and small vessels.
根据世界卫生组织2020年的报告，蒙古中风死亡人数已达4401人，占总死亡人数的19.84%，是蒙古第二大死亡原因。此外，糖尿病的患病率在过去20年里一直在稳步上升。在这项病例对照研究中(80名糖尿病患者和160名非糖尿病患者)，我们分析了过去六个月(2022年6月至12月)来自两个三级卒中中心的数据。纳入标准包括18岁以上就诊于急诊科的急性缺血性卒中患者(根据ICD 10 I63例)。我们回顾并比较了蒙古糖尿病和非糖尿病患者缺血性卒中的临床评估数据，如国立卫生研究院卒中量表(NIHTSS)、格拉斯哥昏迷量表和修正兰金评分、实验室参数和TOAST分类。平均年龄39.2±15.2岁，男性占33.2% (n = 392)。患者的糖尿病病程从0年到23年不等，中位数为5.0年。受试者的平均糖化血红蛋白为9.75±2.49%，只有27.5% (n = 22)的HbA1c低于7.5%。只有糖尿病患者的BMI与非糖尿病患者有显著差异(27.2±4.4比28.6±5.2)。然而，对于其他参数，没有观察到显著差异，但糖尿病患者出院时的NIHTSS明显更高。根据TOAST分类，糖尿病患者微血管病变(18% vs 33.8%， p=0.142)和大血管病变(44.4% vs 57.5%， p=0.192)引起缺血性卒中的风险比非糖尿病患者高13-15%。在回归分析中，糖尿病患者发生动脉粥样硬化引起的缺血性中风的风险是非糖尿病患者的6倍。大多数发生在糖尿病患者身上的中风亚型都是由动脉粥样硬化引起的，包括大血管和小血管。
{"title":"Ischemic stroke subtypes in subjects with and without diabetes: data from two hospitals in Mongolia","authors":"N. Gendendagva, Y. Sankhuu, Anar Bayarmunkh, B. Dagvajantsan, Altaisaikhan Khasag, Oyuntugs Byambasukh","doi":"10.31117/neuroscirn.v6i2.224","DOIUrl":"https://doi.org/10.31117/neuroscirn.v6i2.224","url":null,"abstract":"According to the World Health Organization report in 2020, the number of stroke deaths in Mongolia has reached 4,401, accounting for 19.84% of the total deaths, ranking as the second leading cause of death in Mongolia. Furthermore, the prevalence of diabetes has been steadily increasing for the last 20 years. In this case-control study (80 diabetic and 160 non-diabetic subjects), we analyzed data from two tertiary stroke centers over the past six months (June-December 2022). Inclusion criteria included patients over 18 years who presented to the emergency department with an acute ischemic stroke (I63 according to ICD 10). We reviewed and compared the data on clinical assessments such as the National Institutes of Health The Stroke Scale (NIHTSS), Glasgow Coma Scale and Modified Rankin Score, laboratory parameters, and TOAST classification of ischemic stroke between diabetic and non-diabetic patients in Mongolia. The mean age was 39.2±15.2, and 33.2% (n = 392) were male. The duration of diabetes in patients ranged from 0 to 23 years, and the median was 5.0. Mean glycated haemoglobin in subjects was 9.75±2.49%, and only 27.5% (n = 22) had HbA1c below 7.5%. Only BMI was significantly different in patients with diabetes compared to patients without diabetes (27.2±4.4 vs. 28.6±5.2). However, for other parameters, no significant difference was observed, but the NIHTSS at discharge was significantly higher in patients with diabetes. According to the TOAST classification, the risk of ischemic stroke caused by microangiopathy (18% vs 33.8%, p=0.142) and macroangiopathy (44.4% vs 57.5%, p=0.192) was 13-15% higher in people with diabetes than in people without diabetes. In regression analysis, patients with diabetes had a six times greater risk of ischemic stroke caused by atherosclerosis than non-diabetic patients. Most subtypes of stroke that occur in people with diabetes are caused by atherosclerosis, both large and small vessels.","PeriodicalId":36108,"journal":{"name":"Neuroscience Research Notes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43970976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The Brain and Mind Research Institute (BMRI), affiliated with the Mongolian Academy of Sciences (MAS), in collaboration with the International Brain Research Organization (IBRO) and the Mongolian Neuroscience Society (MNS), organized the Brain Science Week 2022 from August 8 to 13, 2022, in Ulaanbaatar. The Brain Science Week 2022 included three main events: a 6-day training school for neuroscientists, the IBRO-APRC Ulaanbaatar Associate School on Brain-Related Disorders, a roundtable meeting with stakeholders and advisors themed "Perspectives of Brain Science in Mongolia", and the 9th Annual Meeting of MNS, Multidisciplinary Brain Science 2022. In addition, a press conference and an art contest, Brain Have No Limit, were organized to raise brain awareness in public. The IBRO-APRC Ulaanbaatar Associate School on Brain-Related Disorders was aimed to train 20 students on current advances in brain science by seven international faculties and 14 local faculties in six consecutive days. As a satellite event to the school, a 2-day training program for school psychologists, Basic Concepts of Psychology, was held in conjunction with the Mongolian Psychologists Association. The 9th Annual Meeting of MNS brought together 31 speakers and more than 100 participants who attended 14 invited lectures by world-leading neuroscientists in Ulaanbaatar. The support of MAS, the Mongolian National University of Medical Sciences, and the Ministry of Education and Science of Mongolia also contributed to the success of the events. The events made clear what we have achieved so far and what we have to do next for the development of brain science in Mongolia for all participants and the general population.
{"title":"Brain Science Week 2022 in Mongolia","authors":"Amarbayasgalant Badarch, Otgon Zambal, Uyanga Angarag, Nomin-Erdene Otgon, Enkhjin Bat-Erdene, Enkhnaran Tumurbaatar, Battuvshin Lkhagvasuren, Tsolmon Jadamba, Chimeddulam Erdenebaatar","doi":"10.31117/neuroscirn.v6i2.221","DOIUrl":"https://doi.org/10.31117/neuroscirn.v6i2.221","url":null,"abstract":"The Brain and Mind Research Institute (BMRI), affiliated with the Mongolian Academy of Sciences (MAS), in collaboration with the International Brain Research Organization (IBRO) and the Mongolian Neuroscience Society (MNS), organized the Brain Science Week 2022 from August 8 to 13, 2022, in Ulaanbaatar. The Brain Science Week 2022 included three main events: a 6-day training school for neuroscientists, the IBRO-APRC Ulaanbaatar Associate School on Brain-Related Disorders, a roundtable meeting with stakeholders and advisors themed \"Perspectives of Brain Science in Mongolia\", and the 9th Annual Meeting of MNS, Multidisciplinary Brain Science 2022. In addition, a press conference and an art contest, Brain Have No Limit, were organized to raise brain awareness in public. The IBRO-APRC Ulaanbaatar Associate School on Brain-Related Disorders was aimed to train 20 students on current advances in brain science by seven international faculties and 14 local faculties in six consecutive days. As a satellite event to the school, a 2-day training program for school psychologists, Basic Concepts of Psychology, was held in conjunction with the Mongolian Psychologists Association. The 9th Annual Meeting of MNS brought together 31 speakers and more than 100 participants who attended 14 invited lectures by world-leading neuroscientists in Ulaanbaatar. The support of MAS, the Mongolian National University of Medical Sciences, and the Ministry of Education and Science of Mongolia also contributed to the success of the events. The events made clear what we have achieved so far and what we have to do next for the development of brain science in Mongolia for all participants and the general population.","PeriodicalId":36108,"journal":{"name":"Neuroscience Research Notes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44407825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ADHD stands for Attention-deficit hyperactivity disorder; it is a disorder that occurs during childhood development and presents signs of reduced attention and hyperactivity/impulsivity. This study presented the direct association between emotional ability and spectral analysis of electroencephalography of Mongolian children with ADHD. Of a total of 1200 children, who were attending primary schools in Ulaanbaatar, 30 children were diagnosed with ADHD according to Teachers' and Parents' survey versions of DSM-IV ("Diagnostic and Statistical Manual of Mental Disorders"). The sample consisted of 60 children aged 7-12 years (20 % female and 80 males; M age = 9.34, SD = 0.96): 30 children diagnosed with ADHD and 30 healthy children as a control group and presented the same sociodemographic characteristics of the study sample. They all completed Bar-On Quotient Inventory Youth Version (EQ-i: YV), and performed electroencephalography (EEG). Results indicated that children with ADHD presented significantly lower scores in interpersonal scales, adaptability, general mood scales, and total EQ scores than the control group. Comparing forms of ADHD, the intrapersonal scale statistically differed between the hyperactive and combined forms (p = 0.021) and the adaptability scale between attention deficit and the combined form (p = 0.026). Moreover, the study found a statistically significant increase in the posterior delta and theta power, whereas there was a decrease in theta/beta and theta/alpha wave ratio in all brain parts in the ADHD group concerning the healthy group.
{"title":"Attention-deficit hyperactivity in elementary school children in Ulaanbaatar: spectral analysis of electroencephalogram and emotional intelligence","authors":"Amgalan Bayarsaikhan, T. Avirmed, Bayarmaa Tsend, Nasantsengel Lhagvasuren, Battamir Enkhtuya, Erdenetuya Ganbaatar","doi":"10.31117/neuroscirn.v6i2.216","DOIUrl":"https://doi.org/10.31117/neuroscirn.v6i2.216","url":null,"abstract":"ADHD stands for Attention-deficit hyperactivity disorder; it is a disorder that occurs during childhood development and presents signs of reduced attention and hyperactivity/impulsivity. This study presented the direct association between emotional ability and spectral analysis of electroencephalography of Mongolian children with ADHD. Of a total of 1200 children, who were attending primary schools in Ulaanbaatar, 30 children were diagnosed with ADHD according to Teachers' and Parents' survey versions of DSM-IV (\"Diagnostic and Statistical Manual of Mental Disorders\"). The sample consisted of 60 children aged 7-12 years (20 % female and 80 males; M age = 9.34, SD = 0.96): 30 children diagnosed with ADHD and 30 healthy children as a control group and presented the same sociodemographic characteristics of the study sample. They all completed Bar-On Quotient Inventory Youth Version (EQ-i: YV), and performed electroencephalography (EEG). Results indicated that children with ADHD presented significantly lower scores in interpersonal scales, adaptability, general mood scales, and total EQ scores than the control group. Comparing forms of ADHD, the intrapersonal scale statistically differed between the hyperactive and combined forms (p = 0.021) and the adaptability scale between attention deficit and the combined form (p = 0.026). Moreover, the study found a statistically significant increase in the posterior delta and theta power, whereas there was a decrease in theta/beta and theta/alpha wave ratio in all brain parts in the ADHD group concerning the healthy group.","PeriodicalId":36108,"journal":{"name":"Neuroscience Research Notes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41963396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-07DOI: 10.31117/neuroscirn.v6i2.180
Nancy Victoria Castilla-Torres, Zoila Díaz-Tavera, Yovani Condorhuaman-Figueroa, J. Ango-Bedriñana, Juan Kenedy Ramirez
Stroke is a neurological disease. High mortality and sequelae that cause physical or psychological disability demand greater efforts for adequate therapeutic management. The present study aimed to identify signs, symptoms, comorbidities, and therapeutic agents associated with decreased survival time and increased death risk in hospitalized stroke patients. Medical records of stroke patients hospitalized in 2016 at a Peruvian hospital were included. Post-stroke survival time was determined using the Kaplan-Meier method. A comparison of the mean survival time of ischemic and hemorrhagic stroke patients was carried out with the Mantel-Cox test. In addition, the death risk or hazard ratio (HR) was determined using Cox proportional hazards model. The mean survival time was 34.37 (95% CI, 31.89-36.85) and 16.96 (95% CI, 12.35-21.56) days in post-ischemic and hemorrhagic stroke patients, respectively. Dyspnea, peripheral edema, sensory disorder, diffuse cerebral edema and previous stroke are associated with a decrease in survival time. In addition, multivariate analysis revealed that chronic kidney failure (HR=11.98; 95% CI, 2.33-61.68; p=0,003), dyslipidemia (HR=5.19; 95% CI, 1.65-16.32; p=0.005), previous stroke (HR=1.51; 95% CI, 0.41-5.63; p=0.043), and use of antihemorrhagic (HR=1.12; 95% CI, 0.79-1.59; p=0.002) or antiepileptic drugs (HR=1.08; 95% CI, 0.70-1.68; p=0.016) could be considered as death predictors. Clinical and pharmacotherapeutic factors associated with a decrease in mean survival time and increased death risk in hospitalized stroke patients were identified. These factors should be an alarm sign to provide special and timely medical care that reduces the risk of death in patients.
{"title":"Clinical and pharmacotherapeutic factors as survival and death predictors in hospitalized post-stroke patients","authors":"Nancy Victoria Castilla-Torres, Zoila Díaz-Tavera, Yovani Condorhuaman-Figueroa, J. Ango-Bedriñana, Juan Kenedy Ramirez","doi":"10.31117/neuroscirn.v6i2.180","DOIUrl":"https://doi.org/10.31117/neuroscirn.v6i2.180","url":null,"abstract":"Stroke is a neurological disease. High mortality and sequelae that cause physical or psychological disability demand greater efforts for adequate therapeutic management. The present study aimed to identify signs, symptoms, comorbidities, and therapeutic agents associated with decreased survival time and increased death risk in hospitalized stroke patients. Medical records of stroke patients hospitalized in 2016 at a Peruvian hospital were included. Post-stroke survival time was determined using the Kaplan-Meier method. A comparison of the mean survival time of ischemic and hemorrhagic stroke patients was carried out with the Mantel-Cox test. In addition, the death risk or hazard ratio (HR) was determined using Cox proportional hazards model. The mean survival time was 34.37 (95% CI, 31.89-36.85) and 16.96 (95% CI, 12.35-21.56) days in post-ischemic and hemorrhagic stroke patients, respectively. Dyspnea, peripheral edema, sensory disorder, diffuse cerebral edema and previous stroke are associated with a decrease in survival time. In addition, multivariate analysis revealed that chronic kidney failure (HR=11.98; 95% CI, 2.33-61.68; p=0,003), dyslipidemia (HR=5.19; 95% CI, 1.65-16.32; p=0.005), previous stroke (HR=1.51; 95% CI, 0.41-5.63; p=0.043), and use of antihemorrhagic (HR=1.12; 95% CI, 0.79-1.59; p=0.002) or antiepileptic drugs (HR=1.08; 95% CI, 0.70-1.68; p=0.016) could be considered as death predictors. Clinical and pharmacotherapeutic factors associated with a decrease in mean survival time and increased death risk in hospitalized stroke patients were identified. These factors should be an alarm sign to provide special and timely medical care that reduces the risk of death in patients.","PeriodicalId":36108,"journal":{"name":"Neuroscience Research Notes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46086171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-02DOI: 10.31117/neuroscirn.v6i2.182
D. Tafiadis, Louiza Voniati, Alexandra Prentza, Vasiliki Zarokanellou, V. Siafaka, Nafsika Ziavra, S. Konitsiotis
The evaluation of cognitive-communication disorders is performed with several types of assessment methods. These methods include different types of cognitive and language tests such as the Arizona Battery for Communication Disorders of Dementia (ABCD). The present study aimed to validate the ABCD in the Greek language. 132 individuals participated in the study: 60 adults in cognitive health (ACH) and 72 patients [24 Parkinson Disease (PD) patients without cognitive impairment, 24 with Parkinson Disease Dementia (PDD) and 24 with Alzheimer's Disease (AD)]. The cognitive and mental status of all participants was estimated by means of the Mini Mental State Examination (MMSE), the Abbreviated Mental Test Score (AMTS), the Clock Drawing Test (CDT), the Instrumental Activities of Daily Living (IADL), the Neuropsychiatric Inventory (H-NPI) the Geriatric Depression Scale -15 (GDS-15) and the ABCD. Statistically significant differences were found between all tests administered with the PDD and AD patients having the lower scores. The ABCD showed good psychometric properties, internal consistency (Cronbach alpha=0. 901) and discriminatory ability. It was significantly correlated with the AMTS, CDT, IADL, and MMSE.The Greek version of the ABCD demonstrated good validity, sensitivity, and discriminatory ability. The ABCD is a valuable instrument to assess cognitive-communication dis-orders.
{"title":"Validation study of Arizona Battery for Communication Disorders of Dementia in Greek monolingual cognitively impaired patients","authors":"D. Tafiadis, Louiza Voniati, Alexandra Prentza, Vasiliki Zarokanellou, V. Siafaka, Nafsika Ziavra, S. Konitsiotis","doi":"10.31117/neuroscirn.v6i2.182","DOIUrl":"https://doi.org/10.31117/neuroscirn.v6i2.182","url":null,"abstract":"The evaluation of cognitive-communication disorders is performed with several types of assessment methods. These methods include different types of cognitive and language tests such as the Arizona Battery for Communication Disorders of Dementia (ABCD). The present study aimed to validate the ABCD in the Greek language. 132 individuals participated in the study: 60 adults in cognitive health (ACH) and 72 patients [24 Parkinson Disease (PD) patients without cognitive impairment, 24 with Parkinson Disease Dementia (PDD) and 24 with Alzheimer's Disease (AD)]. The cognitive and mental status of all participants was estimated by means of the Mini Mental State Examination (MMSE), the Abbreviated Mental Test Score (AMTS), the Clock Drawing Test (CDT), the Instrumental Activities of Daily Living (IADL), the Neuropsychiatric Inventory (H-NPI) the Geriatric Depression Scale -15 (GDS-15) and the ABCD. Statistically significant differences were found between all tests administered with the PDD and AD patients having the lower scores. The ABCD showed good psychometric properties, internal consistency (Cronbach alpha=0. 901) and discriminatory ability. It was significantly correlated with the AMTS, CDT, IADL, and MMSE.The Greek version of the ABCD demonstrated good validity, sensitivity, and discriminatory ability. The ABCD is a valuable instrument to assess cognitive-communication dis-orders.","PeriodicalId":36108,"journal":{"name":"Neuroscience Research Notes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48964915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-01DOI: 10.31117/neuroscirn.v6i2.181
Gantsetseg Tumur-Ochir, Enkh-Uchral Perenleisambuu, B. Vanchindorj, N. Lkhagvasuren, T. Oka, Battuvshin Lkhagvasuren
Alcohol-related problems are a major health issue in Mongolia and remain underdiagnosed. The nationwide population-based, cross-sectional study reported here was carried out between September and November 2013. It aimed to determine the prevalence of alcohol dependence among the general population using two instruments: the Alcohol Use Disorder Identification Test (AUDIT) and an International Classification of Diseases (ICD)-10 based clinical interview. The AUDIT test, developed by the World Health Organization, was adopted to screen a full spectrum of alcohol-related disorders. Participants identified as at high risk of alcohol dependence were referred to a clinical interview for diagnosis of alcohol dependence. The interview was designed using ICD-10 diagnostic criteria. The study consisted of 11746 participants from 79 clusters, age 18–64 years (n=11746, males 49.1%, females 50.8%, mean age 39.6 ± 12.5 years). 45.4% of the participants (n=5336) abstained from alcohol use, 39% were at low risk of alcohol dependence (n=4582), 9.2% were at moderate risk (n=1075), and 6.4% were at high risk (n=753). Among the participants, a total of 522 participants (4.4%) were diagnosed as having alcohol dependence through the clinical interview. Increased risk of alcohol dependence was associated with those who were men, divorced or widowed, living in rural regions, unemployed, and less educated. The study results suggest that the prevalence of alcohol dependence is 4.4% among the general population of Mongolia. Gender, marital status, geographical location, and education significantly influence alcohol dependence.
与酒精有关的问题是蒙古的一个主要健康问题，但仍未得到充分诊断。这项以全国人口为基础的横断面研究于2013年9月至11月进行。它旨在通过两种工具确定普通人群中酒精依赖的流行程度:酒精使用障碍识别测试(AUDIT)和基于国际疾病分类(ICD)-10的临床访谈。由世界卫生组织(World Health Organization)开发的“审计测试”(AUDIT test)被用来全面筛查与酒精有关的疾病。被确定为酒精依赖高风险的参与者被转介到临床面谈以诊断酒精依赖。访谈采用ICD-10诊断标准设计。研究共纳入79组11746名参与者，年龄18-64岁(n=11746，男性49.1%，女性50.8%，平均年龄39.6±12.5岁)。45.4%的参与者(n=5336)戒酒，39%为低风险酒精依赖(n=4582)， 9.2%为中度风险酒精依赖(n=1075)， 6.4%为高风险酒精依赖(n=753)。通过临床访谈，共有522名参与者(4.4%)被诊断为酒精依赖。男性、离婚或丧偶、生活在农村地区、失业和受教育程度较低的人群酒精依赖风险增加。研究结果表明，蒙古普通人群中酒精依赖的患病率为4.4%。性别、婚姻状况、地理位置和教育程度显著影响酒精依赖。
{"title":"Prevalence of alcohol dependence in Mongolia: a nationwide population-based, cross-sectional study","authors":"Gantsetseg Tumur-Ochir, Enkh-Uchral Perenleisambuu, B. Vanchindorj, N. Lkhagvasuren, T. Oka, Battuvshin Lkhagvasuren","doi":"10.31117/neuroscirn.v6i2.181","DOIUrl":"https://doi.org/10.31117/neuroscirn.v6i2.181","url":null,"abstract":"Alcohol-related problems are a major health issue in Mongolia and remain underdiagnosed. The nationwide population-based, cross-sectional study reported here was carried out between September and November 2013. It aimed to determine the prevalence of alcohol dependence among the general population using two instruments: the Alcohol Use Disorder Identification Test (AUDIT) and an International Classification of Diseases (ICD)-10 based clinical interview. The AUDIT test, developed by the World Health Organization, was adopted to screen a full spectrum of alcohol-related disorders. Participants identified as at high risk of alcohol dependence were referred to a clinical interview for diagnosis of alcohol dependence. The interview was designed using ICD-10 diagnostic criteria. The study consisted of 11746 participants from 79 clusters, age 18–64 years (n=11746, males 49.1%, females 50.8%, mean age 39.6 ± 12.5 years). 45.4% of the participants (n=5336) abstained from alcohol use, 39% were at low risk of alcohol dependence (n=4582), 9.2% were at moderate risk (n=1075), and 6.4% were at high risk (n=753). Among the participants, a total of 522 participants (4.4%) were diagnosed as having alcohol dependence through the clinical interview. Increased risk of alcohol dependence was associated with those who were men, divorced or widowed, living in rural regions, unemployed, and less educated. The study results suggest that the prevalence of alcohol dependence is 4.4% among the general population of Mongolia. Gender, marital status, geographical location, and education significantly influence alcohol dependence.","PeriodicalId":36108,"journal":{"name":"Neuroscience Research Notes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44316710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-29DOI: 10.31117/neuroscirn.v6i2.212
Muhammad Naveed, Lei Han, S. Noreen, Chaoyue Zhao, Gang Sheng, Lulu Xu, Xiao-hui Zhou
The dorsal root ganglia (DRG) neurons have long been studied to advance the understanding of sensory nerve function and growth. DRG neurons are also involved in determining the fundamental mechanisms of neurodegenerative and painful disorders of the peripheral nervous system. To explore the simple methods of rapid and accurate removal of DRG in anesthetized rats with the naked eye without destroying the spinal column or blood circulation. Male Wistar rats were fixed on the operating table, lumbar DRG was removed, and sufficient DRG neurons were harvested without microscopic equipment. At the same time, the procedure was accomplished without disruption to breathing and circulation. These approaches reduce the time required for DRG collection, thereby improving efficiency, and increasing the chances of generating healthy primary DRG cultures and reproducible experiments using DRG tissue.
{"title":"Simple methods of dissection protocols for the rapid isolation of rat dorsal root ganglia under the non-microscopic condition","authors":"Muhammad Naveed, Lei Han, S. Noreen, Chaoyue Zhao, Gang Sheng, Lulu Xu, Xiao-hui Zhou","doi":"10.31117/neuroscirn.v6i2.212","DOIUrl":"https://doi.org/10.31117/neuroscirn.v6i2.212","url":null,"abstract":"The dorsal root ganglia (DRG) neurons have long been studied to advance the understanding of sensory nerve function and growth. DRG neurons are also involved in determining the fundamental mechanisms of neurodegenerative and painful disorders of the peripheral nervous system. To explore the simple methods of rapid and accurate removal of DRG in anesthetized rats with the naked eye without destroying the spinal column or blood circulation. Male Wistar rats were fixed on the operating table, lumbar DRG was removed, and sufficient DRG neurons were harvested without microscopic equipment. At the same time, the procedure was accomplished without disruption to breathing and circulation. These approaches reduce the time required for DRG collection, thereby improving efficiency, and increasing the chances of generating healthy primary DRG cultures and reproducible experiments using DRG tissue.","PeriodicalId":36108,"journal":{"name":"Neuroscience Research Notes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48743304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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