Pub Date : 2024-06-17DOI: 10.1016/j.xinn.2024.100658
Brett J. Kagan, Michael Mahlis, Anjali Bhat, Josh Bongard, Victor M. Cole, Phillip Corlett, Christopher Gyngell, Thomas Hartung, Bianca Jupp, Michael Levin, Tamra Lysaght, Nicholas Opie, Adeel Razi, Lena Smirnova, Ian Tennant, Peter Thestrup Wade, Ge Wang
Disagreements about language use are common both between and within fields. Where interests require multidisciplinary collaboration or the field of research has the potential to impact society at large, it becomes critical to minimize these disagreements where possible. The development of diverse intelligent systems, regardless of the substrate (e.g., silicon vs. biology), is a case where both conditions are met. Significant advancements have occurred in the development of technology progressing toward these diverse intelligence systems. Whether progress is silicon based, such as the use of large language models, or through synthetic biology methods, such as the development of organoids, a clear need for a community-based approach to seeking consensus on nomenclature is now vital. Here, we welcome collaboration from the wider scientific community, proposing a pathway forward to achieving this intention, highlighting key terms and fields of relevance, and suggesting potential consensus-making methods to be applied.
{"title":"Toward a nomenclature consensus for diverse intelligent systems: Call for collaboration","authors":"Brett J. Kagan, Michael Mahlis, Anjali Bhat, Josh Bongard, Victor M. Cole, Phillip Corlett, Christopher Gyngell, Thomas Hartung, Bianca Jupp, Michael Levin, Tamra Lysaght, Nicholas Opie, Adeel Razi, Lena Smirnova, Ian Tennant, Peter Thestrup Wade, Ge Wang","doi":"10.1016/j.xinn.2024.100658","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100658","url":null,"abstract":"Disagreements about language use are common both between and within fields. Where interests require multidisciplinary collaboration or the field of research has the potential to impact society at large, it becomes critical to minimize these disagreements where possible. The development of diverse intelligent systems, regardless of the substrate (e.g., silicon vs. biology), is a case where both conditions are met. Significant advancements have occurred in the development of technology progressing toward these diverse intelligence systems. Whether progress is silicon based, such as the use of large language models, or through synthetic biology methods, such as the development of organoids, a clear need for a community-based approach to seeking consensus on nomenclature is now vital. Here, we welcome collaboration from the wider scientific community, proposing a pathway forward to achieving this intention, highlighting key terms and fields of relevance, and suggesting potential consensus-making methods to be applied.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"26 1","pages":""},"PeriodicalIF":32.1,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141504304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-17DOI: 10.1016/j.xinn.2024.100659
Zhiwei Chen, Hongru Zhou, Fanhao Kong, Zhaolin Dou, Min Wang
Photocatalysis has shown powerful capabilities in organic reactions, while controlling the selectivity is a long-standing goal and challenge due to the involvement of various radical intermediates. In this study, we have realized selectivity control in the photocatalytic conversion of alcohols via engineering the surface static electric field of the CdS semiconductor. By leveraging the Au–CdS interaction to adjust lattice strain, which influences the intensity of the surface static electric field, we altered the pathways of alcohol conversion. The increased intensity of the surface static electric field changed the activation pathways of the C–H/O–H bond, leading to the selective formation of targeted C/O-based radical intermediates and altering the selectivity from aldehydes to dimers. A wide range of alcohols, such as aromatic alcohol and thiophenol alcohol, were selectively converted into aldehyde or dimer. This work provides an effective strategy for selectively controlling reaction pathways by generating a surface electric field.
{"title":"Selectivity switch via tuning surface static electric field in photocatalytic alcohol conversion","authors":"Zhiwei Chen, Hongru Zhou, Fanhao Kong, Zhaolin Dou, Min Wang","doi":"10.1016/j.xinn.2024.100659","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100659","url":null,"abstract":"Photocatalysis has shown powerful capabilities in organic reactions, while controlling the selectivity is a long-standing goal and challenge due to the involvement of various radical intermediates. In this study, we have realized selectivity control in the photocatalytic conversion of alcohols via engineering the surface static electric field of the CdS semiconductor. By leveraging the Au–CdS interaction to adjust lattice strain, which influences the intensity of the surface static electric field, we altered the pathways of alcohol conversion. The increased intensity of the surface static electric field changed the activation pathways of the C–H/O–H bond, leading to the selective formation of targeted C/O-based radical intermediates and altering the selectivity from aldehydes to dimers. A wide range of alcohols, such as aromatic alcohol and thiophenol alcohol, were selectively converted into aldehyde or dimer. This work provides an effective strategy for selectively controlling reaction pathways by generating a surface electric field.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"15 1","pages":""},"PeriodicalIF":32.1,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141548800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-27DOI: 10.1016/j.xinn.2024.100650
Jianlong Xie, Qiyin Chen, Qin Xue, Igor F. Perepichka, Guohua Xie
{"title":"H2O2-modified NiOx for perovskite photovoltaic modules","authors":"Jianlong Xie, Qiyin Chen, Qin Xue, Igor F. Perepichka, Guohua Xie","doi":"10.1016/j.xinn.2024.100650","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100650","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"52 1","pages":""},"PeriodicalIF":32.1,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141254780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-26DOI: 10.1016/j.xinn.2024.100630
Xiuqi You, Ximin Chen, Yi Jiang, Huan Chen, Juan Liu, Zhen Wu, Weiling Sun, Jinren Ni
Photosynthetic carbon fixation by cyanobacteria plays a pivotal role in the global carbon cycle but is threatened by environmental pollutants. To date, the impact of quinones, with electron shuttling properties, on cyanobacterial photosynthesis is unknown. Here, we present the first study investigating the effects of an emerging quinone pollutant, i.e., 6PPD-Q (N-(1,3-dimethylbutyl)-N′-phenyl--phenylenediamine-quinone), on the cyanobacterium sp. over a 400-generation exposure period. sp. exhibited distinct sequential phases, including hormesis, toxicity, and eventual recovery, throughout this exposure. Extensive evidence, including results of thylakoid membrane morphological and photosynthetic responses, carbon fixation rate, and key gene/protein analyses, strongly indicates that 6PPD-Q is a potent disruptor of photosynthesis. 6PPD-Q accepts photosynthetic electrons at the Q site in photosystem II (PSII) and the A site in PSI, leading to a sustained decrease in the carbon fixation of cyanobacteria after an ephemeral increase. This work revealed the specific mechanism by which 6PPD-Q interferes with photosynthetic carbon fixation in cyanobacteria, which is highly important for the global carbon cycle.
{"title":"6PPD-quinone affects the photosynthetic carbon fixation in cyanobacteria by extracting photosynthetic electrons","authors":"Xiuqi You, Ximin Chen, Yi Jiang, Huan Chen, Juan Liu, Zhen Wu, Weiling Sun, Jinren Ni","doi":"10.1016/j.xinn.2024.100630","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100630","url":null,"abstract":"Photosynthetic carbon fixation by cyanobacteria plays a pivotal role in the global carbon cycle but is threatened by environmental pollutants. To date, the impact of quinones, with electron shuttling properties, on cyanobacterial photosynthesis is unknown. Here, we present the first study investigating the effects of an emerging quinone pollutant, i.e., 6PPD-Q (N-(1,3-dimethylbutyl)-N′-phenyl--phenylenediamine-quinone), on the cyanobacterium sp. over a 400-generation exposure period. sp. exhibited distinct sequential phases, including hormesis, toxicity, and eventual recovery, throughout this exposure. Extensive evidence, including results of thylakoid membrane morphological and photosynthetic responses, carbon fixation rate, and key gene/protein analyses, strongly indicates that 6PPD-Q is a potent disruptor of photosynthesis. 6PPD-Q accepts photosynthetic electrons at the Q site in photosystem II (PSII) and the A site in PSI, leading to a sustained decrease in the carbon fixation of cyanobacteria after an ephemeral increase. This work revealed the specific mechanism by which 6PPD-Q interferes with photosynthetic carbon fixation in cyanobacteria, which is highly important for the global carbon cycle.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"61 1","pages":""},"PeriodicalIF":32.1,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140882784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-05DOI: 10.1016/j.xinn.2024.100621
Ziyan Chen, Xin Liu, Zixi Jiang, Huayi Wu, Tao Yang, Lanyuan Peng, Lisha Wu, Zhongling Luo, Mi Zhang, Juan Su, Yan Tang, Jinmao Li, Yang Xie, Han Shan, Qibo Lin, Xiuli Wang, Xiang Chen, Hanmin Peng, Shuang Zhao, Zeyu Chen
With over a million cases detected each year, skin disease is a global public health problem that diminishes the quality of life due to its difficulty to eradicate, propensity for recurrence, and potential for post-treatment scarring. Photodynamic therapy (PDT) is a treatment with minimal invasiveness or scarring and few side effects, making it well tolerated by patients. However, this treatment requires further research and development to improve its effective clinical use. Here, a piezoelectric-driven microneedle (PDMN) platform that achieves high efficiency, safety, and non-invasiveness for enhanced PDT is proposed. This platform induces deep tissue cavitation, increasing the level of protoporphyrin IX and significantly enhancing drug penetration. A clinical trial involving 25 patients with skin disease was conducted to investigate the timeliness and efficacy of PDMN-assisted PDT (PDMN-PDT). Our findings suggested that PDMN-PDT boosted treatment effectiveness and reduced the required incubation time and drug concentration by 25% and 50%, respectively, without any anesthesia compared to traditional PDT. These findings suggest that PDMN-PDT is a safe and minimally invasive approach for skin disease treatment, which may improve the therapeutic efficacy of topical medications and enable translation for future clinical applications.
{"title":"A piezoelectric-driven microneedle platform for skin disease therapy","authors":"Ziyan Chen, Xin Liu, Zixi Jiang, Huayi Wu, Tao Yang, Lanyuan Peng, Lisha Wu, Zhongling Luo, Mi Zhang, Juan Su, Yan Tang, Jinmao Li, Yang Xie, Han Shan, Qibo Lin, Xiuli Wang, Xiang Chen, Hanmin Peng, Shuang Zhao, Zeyu Chen","doi":"10.1016/j.xinn.2024.100621","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100621","url":null,"abstract":"With over a million cases detected each year, skin disease is a global public health problem that diminishes the quality of life due to its difficulty to eradicate, propensity for recurrence, and potential for post-treatment scarring. Photodynamic therapy (PDT) is a treatment with minimal invasiveness or scarring and few side effects, making it well tolerated by patients. However, this treatment requires further research and development to improve its effective clinical use. Here, a piezoelectric-driven microneedle (PDMN) platform that achieves high efficiency, safety, and non-invasiveness for enhanced PDT is proposed. This platform induces deep tissue cavitation, increasing the level of protoporphyrin IX and significantly enhancing drug penetration. A clinical trial involving 25 patients with skin disease was conducted to investigate the timeliness and efficacy of PDMN-assisted PDT (PDMN-PDT). Our findings suggested that PDMN-PDT boosted treatment effectiveness and reduced the required incubation time and drug concentration by 25% and 50%, respectively, without any anesthesia compared to traditional PDT. These findings suggest that PDMN-PDT is a safe and minimally invasive approach for skin disease treatment, which may improve the therapeutic efficacy of topical medications and enable translation for future clinical applications.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"50 1","pages":""},"PeriodicalIF":32.1,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140596077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：