Pub Date : 2024-04-02DOI: 10.1016/j.xinn.2024.100622
Yi-Da Tang, Er-Dan Dong, Wen Gao
{"title":"LLMs in medicine: The need for advanced evaluation systems for disruptive technologies","authors":"Yi-Da Tang, Er-Dan Dong, Wen Gao","doi":"10.1016/j.xinn.2024.100622","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100622","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"18 1","pages":""},"PeriodicalIF":32.1,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140596071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-02DOI: 10.1016/j.xinn.2024.100623
Guo-Bo Chen, Siyang Liu, Lei Zhang, Tao Huang, Xiaohua Tang, Yixue Li, Changqing Zeng
{"title":"Building and sharing medical cohorts for research","authors":"Guo-Bo Chen, Siyang Liu, Lei Zhang, Tao Huang, Xiaohua Tang, Yixue Li, Changqing Zeng","doi":"10.1016/j.xinn.2024.100623","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100623","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"17 1","pages":""},"PeriodicalIF":32.1,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140596076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the last decade, organoid research has entered a golden era, signifying a pivotal shift in the biomedical landscape. The year 2023 marked a milestone with the publication of thousands of papers in this arena, reflecting exponential growth. However, amid this burgeoning expansion, a comprehensive and accurate overview of the field has been conspicuously absent. Our review is intended to bridge this gap, providing a panoramic view of the rapidly evolving organoid landscape. We meticulously analyze the organoid field from eight distinctive vantage points, harnessing our rich experience in academic research, industrial application, and clinical practice. We present a deep exploration of the advances in organoid technology, underpinned by our long-standing involvement in this arena. Our narrative traverses the historical genesis of organoids and their transformative impact across various biomedical sectors, including oncology, toxicology, and drug development. We delve into the synergy between organoids and avant-garde technologies such as synthetic biology and single-cell omics and discuss their pivotal role in tailoring personalized medicine, enhancing high-throughput drug screening, and constructing physiologically pertinent disease models. Our comprehensive analysis and reflective discourse provide a deep dive into the existing landscape and emerging trends in organoid technology. We spotlight technological innovations, methodological evolution, and the broadening spectrum of applications, emphasizing the revolutionary influence of organoids in personalized medicine, oncology, drug discovery, and other fields. Looking ahead, we cautiously anticipate future developments in the field of organoid research, especially its potential implications for personalized patient care, new avenues of drug discovery, and clinical research. We trust that our comprehensive review will be an asset for researchers, clinicians, and patients with keen interest in personalized medical strategies. We offer a broad view of the present and prospective capabilities of organoid technology, encompassing a wide range of current and future applications. In summary, in this review we attempt a comprehensive exploration of the organoid field. We offer reflections, summaries, and projections that might be useful for current researchers and clinicians, and we hope to contribute to shaping the evolving trajectory of this dynamic and rapidly advancing field.
{"title":"Landscape of human organoids: Ideal model in clinics and research","authors":"Xinxin Han, Chunhui Cai, Wei Deng, Yanghua Shi, Lanyang Li, Chen Wang, Jian Zhang, Mingjie Rong, Jiping Liu, Bangjiang Fang, Hua He, Xiling Liu, Chuxia Deng, Xiao He, Xin Cao","doi":"10.1016/j.xinn.2024.100620","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100620","url":null,"abstract":"In the last decade, organoid research has entered a golden era, signifying a pivotal shift in the biomedical landscape. The year 2023 marked a milestone with the publication of thousands of papers in this arena, reflecting exponential growth. However, amid this burgeoning expansion, a comprehensive and accurate overview of the field has been conspicuously absent. Our review is intended to bridge this gap, providing a panoramic view of the rapidly evolving organoid landscape. We meticulously analyze the organoid field from eight distinctive vantage points, harnessing our rich experience in academic research, industrial application, and clinical practice. We present a deep exploration of the advances in organoid technology, underpinned by our long-standing involvement in this arena. Our narrative traverses the historical genesis of organoids and their transformative impact across various biomedical sectors, including oncology, toxicology, and drug development. We delve into the synergy between organoids and avant-garde technologies such as synthetic biology and single-cell omics and discuss their pivotal role in tailoring personalized medicine, enhancing high-throughput drug screening, and constructing physiologically pertinent disease models. Our comprehensive analysis and reflective discourse provide a deep dive into the existing landscape and emerging trends in organoid technology. We spotlight technological innovations, methodological evolution, and the broadening spectrum of applications, emphasizing the revolutionary influence of organoids in personalized medicine, oncology, drug discovery, and other fields. Looking ahead, we cautiously anticipate future developments in the field of organoid research, especially its potential implications for personalized patient care, new avenues of drug discovery, and clinical research. We trust that our comprehensive review will be an asset for researchers, clinicians, and patients with keen interest in personalized medical strategies. We offer a broad view of the present and prospective capabilities of organoid technology, encompassing a wide range of current and future applications. In summary, in this review we attempt a comprehensive exploration of the organoid field. We offer reflections, summaries, and projections that might be useful for current researchers and clinicians, and we hope to contribute to shaping the evolving trajectory of this dynamic and rapidly advancing field.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"21 1","pages":""},"PeriodicalIF":32.1,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140596011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-13DOI: 10.1016/j.xinn.2024.100612
Fang Wang, Leilei Xiang, Kelvin Sze-Yin Leung, Martin Elsner, Ying Zhang, Yuming Guo, Bo Pan, Hongwen Sun, Taicheng An, Guangguo Ying, Bryan W. Brooks, Deyi Hou, Damian E. Helbling, Jianqiang Sun, Hao Qiu, Timothy M. Vogel, Wei Zhang, Yanzheng Gao, Myrna J. Simpson, Yi Luo, Scott X. Chang, Guanyong Su, Bryan M. Wong, Tzung-May Fu, Dong Zhu, Karl J. Jobst, Chengjun Ge, Frederic Coulon, Jean Damascene Harindintwali, Xiankui Zeng, Haijun Wang, Yuhao Fu, Zhong Wei, Rainer Lohmann, Changer Chen, Yang Song, Concepcion Sanchez-Cid, Yu Wang, Ali El-Naggar, Yiming Yao, Yanran Huang, Japhet Cheuk-Fung Law, Chenggang Gu, Huizhong Shen, Yanpeng Gao, Chao Qin, Hao Li, Tong Zhang, Natàlia Corcoll, Min Liu, Daniel S. Alessi, Hui Li, Kristian K. Brandt, Yolanda Pico, Cheng Gu, Jianhua Guo, Jianqiang Su, Philippe Corvini, Mao Ye, Teresa Rocha-Santos, Huan He, Yi Yang, Meiping Tong, Weina Zhang, Fidèle Suanon, Ferdi Brahushi, Zhenyu Wang, Syed A. Hashsham, Marko Virta, Qingbin Yuan, Gaofei Jiang, Louis A. Tremblay, Qingwei Bu, Jichun Wu, Willie Peijnenburg, Edward Topp, Xinde Cao, Xin Jiang, Minghui Zheng, Taolin Zhang, Yongming Luo, Lizhong Zhu, Xiangdong Li, Damià Barceló, Jianmin Chen, Baoshan Xing, Wulf Amelung, Zongwei Cai, Ravi Naidu, Qirong Shen, Janusz Pawliszyn, Yong-guan Zhu, Andreas Schaeffer, Matthias C. Rillig, Fengchang Wu, Gang Yu, James M. Tiedje
Environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary health. Despite global efforts to mitigate legacy pollutants, the continuous introduction of new substances remains a major threat to both human and ecosystem health. In response, global initiatives are focusing on risk assessment and regulation of emerging contaminants, as demonstrated by the establishment of the UN’s Intergovernmental Science-Policy Panel on Chemicals, Waste, and Pollution Prevention. This review identifies the sources and impacts of emerging contaminants on planetary health, emphasizing the importance of adopting a One Health approach. Strategies for monitoring and addressing these pollutants are discussed, underscoring the need for robust and socially equitable environmental policies at both regional and international levels. Urgent actions are needed to transition towards sustainable pollution management practices to safeguard our planet for future generations.
{"title":"Emerging Contaminants: A One Health Perspective","authors":"Fang Wang, Leilei Xiang, Kelvin Sze-Yin Leung, Martin Elsner, Ying Zhang, Yuming Guo, Bo Pan, Hongwen Sun, Taicheng An, Guangguo Ying, Bryan W. Brooks, Deyi Hou, Damian E. Helbling, Jianqiang Sun, Hao Qiu, Timothy M. Vogel, Wei Zhang, Yanzheng Gao, Myrna J. Simpson, Yi Luo, Scott X. Chang, Guanyong Su, Bryan M. Wong, Tzung-May Fu, Dong Zhu, Karl J. Jobst, Chengjun Ge, Frederic Coulon, Jean Damascene Harindintwali, Xiankui Zeng, Haijun Wang, Yuhao Fu, Zhong Wei, Rainer Lohmann, Changer Chen, Yang Song, Concepcion Sanchez-Cid, Yu Wang, Ali El-Naggar, Yiming Yao, Yanran Huang, Japhet Cheuk-Fung Law, Chenggang Gu, Huizhong Shen, Yanpeng Gao, Chao Qin, Hao Li, Tong Zhang, Natàlia Corcoll, Min Liu, Daniel S. Alessi, Hui Li, Kristian K. Brandt, Yolanda Pico, Cheng Gu, Jianhua Guo, Jianqiang Su, Philippe Corvini, Mao Ye, Teresa Rocha-Santos, Huan He, Yi Yang, Meiping Tong, Weina Zhang, Fidèle Suanon, Ferdi Brahushi, Zhenyu Wang, Syed A. Hashsham, Marko Virta, Qingbin Yuan, Gaofei Jiang, Louis A. Tremblay, Qingwei Bu, Jichun Wu, Willie Peijnenburg, Edward Topp, Xinde Cao, Xin Jiang, Minghui Zheng, Taolin Zhang, Yongming Luo, Lizhong Zhu, Xiangdong Li, Damià Barceló, Jianmin Chen, Baoshan Xing, Wulf Amelung, Zongwei Cai, Ravi Naidu, Qirong Shen, Janusz Pawliszyn, Yong-guan Zhu, Andreas Schaeffer, Matthias C. Rillig, Fengchang Wu, Gang Yu, James M. Tiedje","doi":"10.1016/j.xinn.2024.100612","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100612","url":null,"abstract":"Environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary health. Despite global efforts to mitigate legacy pollutants, the continuous introduction of new substances remains a major threat to both human and ecosystem health. In response, global initiatives are focusing on risk assessment and regulation of emerging contaminants, as demonstrated by the establishment of the UN’s Intergovernmental Science-Policy Panel on Chemicals, Waste, and Pollution Prevention. This review identifies the sources and impacts of emerging contaminants on planetary health, emphasizing the importance of adopting a One Health approach. Strategies for monitoring and addressing these pollutants are discussed, underscoring the need for robust and socially equitable environmental policies at both regional and international levels. Urgent actions are needed to transition towards sustainable pollution management practices to safeguard our planet for future generations.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"152 1","pages":""},"PeriodicalIF":32.1,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140170763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-12DOI: 10.1016/j.xinn.2024.100611
Jing Ma, Huiwen Kong, Jianxiao Wang, Haiwang Zhong, Bo Li, Jie Song, Daniel M. Kammen
{"title":"Carbon-neutral pathway to mitigating transport-power grid cross-sector effects","authors":"Jing Ma, Huiwen Kong, Jianxiao Wang, Haiwang Zhong, Bo Li, Jie Song, Daniel M. Kammen","doi":"10.1016/j.xinn.2024.100611","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100611","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"5 1","pages":""},"PeriodicalIF":32.1,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140170768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Increasing impacts of fire air pollution on public and ecosystem health","authors":"Xu Yue, Yihan Hu, Chenguang Tian, Rongbin Xu, Wenhua Yu, Yuming Guo","doi":"10.1016/j.xinn.2024.100609","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100609","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"101 1","pages":""},"PeriodicalIF":32.1,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140170857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The vaccine-induced innate immune response is essential for the generation of an antibody response. To date, how Ad5-vectored vaccines are influenced by preexisting anti-Ad5 antibodies during activation of the early immune response remains unclear. Here, we investigated the specific alterations in GP-specific IgG-related elements of the early immune response at the genetic, molecular, and cellular levels on days 0, 1, 3, and 7 after Ad5-EBOV vaccination. In a causal multiomics analysis, distinct early immune responses associated with GP-specific IgG were observed in Ad5-EBOV recipients with a low level of preexisting anti-Ad5 antibodies. This study revealed the correlates of the Ad5-EBOV-induced IgG response and provided mechanistic evidence for overcoming preexisting Ad5 immunity during the administration of Ad5-vectored vaccines.
{"title":"A causal multiomics study discriminates the early immune features of Ad5-vectored Ebola vaccine recipients","authors":"Zhe Zhang, Wenjing Yang, Zhengshan Chen, Haoang Chi, Shipo Wu, Wanru Zheng, Ruochun Jin, Busen Wang, Yudong Wang, Nan Huo, Jinlong Zhang, Xiaohong Song, Liyang Xu, Jun Zhang, Lihua Hou, Wei Chen","doi":"10.1016/j.xinn.2024.100603","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100603","url":null,"abstract":"The vaccine-induced innate immune response is essential for the generation of an antibody response. To date, how Ad5-vectored vaccines are influenced by preexisting anti-Ad5 antibodies during activation of the early immune response remains unclear. Here, we investigated the specific alterations in GP-specific IgG-related elements of the early immune response at the genetic, molecular, and cellular levels on days 0, 1, 3, and 7 after Ad5-EBOV vaccination. In a causal multiomics analysis, distinct early immune responses associated with GP-specific IgG were observed in Ad5-EBOV recipients with a low level of preexisting anti-Ad5 antibodies. This study revealed the correlates of the Ad5-EBOV-induced IgG response and provided mechanistic evidence for overcoming preexisting Ad5 immunity during the administration of Ad5-vectored vaccines.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"1 1","pages":""},"PeriodicalIF":32.1,"publicationDate":"2024-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140107367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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