Uğur Kemal ÖZTÜRK, Sami AÇAR, Serkan AKIŞ, Esra KELEŞ, Erman ÇİFTÇİ, Murat APİ
Objective: To compare leiomyoma variants and leiomyosarcoma (LMS) in terms of clinicopathological characteristics. Material and Methods: We evaluated the clinical and pathology outcomes of 57 patients who underwent myomectomy or hysterectomy between September 2013 and August 2022 and were diagnosed with cellular leiomyoma (CL), mitotically active leiomyoma (MAL), leiomyoma with bizarre nuclei (LBN), or LMS. Intraoperative frozen results were compared with the final pathology results. Leiomyoma variants (CL, MAL, and LBN) were compared with each other and with LMS. Results: Patients in the LMS group were older than those in the leiomyoma variants group (p<0.001). Frozen results in the variant group was 6.7% malignant, whereas 100% in the LMS group. Age (p=0.207), menopausal status (p=0.347), fibroid size (p=0.432), and number (p=0.598) did not differ between CL, MAL, and LBN groups. The median follow-up of leiomyoma variants and LMS groups was 61 months (4-105 months) and 20.5 months (6-85 months), respectively. No recurrence was observed in leiomyoma variants group whereas, recurrence was observed in 5 patients, and 3 patients died after recurrence in the LMS group. Conclusion: In this study, no recurrence was observed in the leiomyoma variants groups during the follow-up period and the prognosis is favorable. Not all tumors in the group of leiomyoma variants already meet the diagnostic criteria for LMS. Therefore, the detailed naming of the leiomyoma variants by subgroups does not seem to be of additional benefit for patient follow-up.
{"title":"Clinicopathological Comparison of Leiomyoma Variants and Leiomyosarcomas: A Retrospective Analysis","authors":"Uğur Kemal ÖZTÜRK, Sami AÇAR, Serkan AKIŞ, Esra KELEŞ, Erman ÇİFTÇİ, Murat APİ","doi":"10.5336/jcog.2023-97716","DOIUrl":"https://doi.org/10.5336/jcog.2023-97716","url":null,"abstract":"Objective: To compare leiomyoma variants and leiomyosarcoma (LMS) in terms of clinicopathological characteristics. Material and Methods: We evaluated the clinical and pathology outcomes of 57 patients who underwent myomectomy or hysterectomy between September 2013 and August 2022 and were diagnosed with cellular leiomyoma (CL), mitotically active leiomyoma (MAL), leiomyoma with bizarre nuclei (LBN), or LMS. Intraoperative frozen results were compared with the final pathology results. Leiomyoma variants (CL, MAL, and LBN) were compared with each other and with LMS. Results: Patients in the LMS group were older than those in the leiomyoma variants group (p<0.001). Frozen results in the variant group was 6.7% malignant, whereas 100% in the LMS group. Age (p=0.207), menopausal status (p=0.347), fibroid size (p=0.432), and number (p=0.598) did not differ between CL, MAL, and LBN groups. The median follow-up of leiomyoma variants and LMS groups was 61 months (4-105 months) and 20.5 months (6-85 months), respectively. No recurrence was observed in leiomyoma variants group whereas, recurrence was observed in 5 patients, and 3 patients died after recurrence in the LMS group. Conclusion: In this study, no recurrence was observed in the leiomyoma variants groups during the follow-up period and the prognosis is favorable. Not all tumors in the group of leiomyoma variants already meet the diagnostic criteria for LMS. Therefore, the detailed naming of the leiomyoma variants by subgroups does not seem to be of additional benefit for patient follow-up.","PeriodicalId":36268,"journal":{"name":"Journal of Clinical Obstetrics and Gynecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135600746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gestational alloimmune liver disease (GALD) is characterized by complement-mediated hepatocyte damage by transplacental transmission of maternal antibodies against fetal hepatocyte antigens. GALD's recurrence occurs up to 90% in pregnancies after an affected pregnancy. Intravenous immunoglobulin (IVIG) is a sterile, purified immunoglobulin (IgG) product that is manufactured from pooled human plasma. IVIG typically contains more than 95% unmodified IgG which has intact fragment crystallizable-dependent effector functions in addition to trace amounts of IgA and/or IgM. Indeed, antenatal high-dose IVIG treatment effectively reduces the risk of recurrence. In the present study, we reported two cases with GALD recurrence which was prevented by maternal IVIG administration in the second trimester.
{"title":"Prevention of Gestational Alloimmune Liver Disease by Intravenous Immunoglobulin Administration in the Second Trimester: A Presentation of Two Cases","authors":"Gül ALKAN BÜLBÜL, Emine KİRTİŞ, Hülya KANDEMİR, Arzu ARAS, Özlem ELPEK, Cem Yaşar SANHAL","doi":"10.5336/jcog.2023-97913","DOIUrl":"https://doi.org/10.5336/jcog.2023-97913","url":null,"abstract":"Gestational alloimmune liver disease (GALD) is characterized by complement-mediated hepatocyte damage by transplacental transmission of maternal antibodies against fetal hepatocyte antigens. GALD's recurrence occurs up to 90% in pregnancies after an affected pregnancy. Intravenous immunoglobulin (IVIG) is a sterile, purified immunoglobulin (IgG) product that is manufactured from pooled human plasma. IVIG typically contains more than 95% unmodified IgG which has intact fragment crystallizable-dependent effector functions in addition to trace amounts of IgA and/or IgM. Indeed, antenatal high-dose IVIG treatment effectively reduces the risk of recurrence. In the present study, we reported two cases with GALD recurrence which was prevented by maternal IVIG administration in the second trimester.","PeriodicalId":36268,"journal":{"name":"Journal of Clinical Obstetrics and Gynecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135600750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cihat Murat ALINCA, Esra KELEŞ, Uğur Kemal ÖZTÜRK, Burak GİRAY, Serkan AKIŞ, Canan KABACA
Objective: Female genital system carcinosarcomas are rare gynecologic diseases that most commonly involve the corpus uteri. This study aimed to investigate the differences between uterine and ovarian carcinosarcomas in terms of histological, clinicopathological, and survival characteristics and evaluate the adjuvant treatment options received by patients, particularly at the sites of the first relapse. Material and Method: This retrospective study was conducted on patients with the diagnosis of uterine carcinosarcomas and ovarian carcinosarcomas treated between January 1, 2006, and December 31, 2020. Records of 54 patients (42 patients with uterine carcinosarcoma and 12 patients with ovarian carcinosarcoma) who underwent debulking surgery were analyzed. Results: No difference was found in terms of mean tumor diameter, lymphovascular space invasion, lymph node involvement, and omental assessment. Recurrence occurred in 18 patients with uterine carcinosarcoma and eight patients with ovarian carcinosarcoma. Distant organ metastases such as lung or brain were not detected in any of the patients during the follow-ups. Kaplan'Meier analysis showed that disease-free survival (DFS) and overall survival (OS) in the uterine carcinosarcoma and ovarian carcinosarcoma groups were similar (p=0 .938 for OS and p=0.328 for DFS). Conclusion: Ovarian carcinosarcomas can be seen at an earlier age than uterine carcinosarcomas, and it has fewer signs that may indicate disease. It should be underlined that 41.7% of patients with ovarian carcinosarcoma were in the premenopausal period.
{"title":"Clinicopathological Characteristics and Survival Outcome in Uterine and Ovarian Carcinosarcomas: A Comparative Study","authors":"Cihat Murat ALINCA, Esra KELEŞ, Uğur Kemal ÖZTÜRK, Burak GİRAY, Serkan AKIŞ, Canan KABACA","doi":"10.5336/jcog.2022-94995","DOIUrl":"https://doi.org/10.5336/jcog.2022-94995","url":null,"abstract":"Objective: Female genital system carcinosarcomas are rare gynecologic diseases that most commonly involve the corpus uteri. This study aimed to investigate the differences between uterine and ovarian carcinosarcomas in terms of histological, clinicopathological, and survival characteristics and evaluate the adjuvant treatment options received by patients, particularly at the sites of the first relapse. Material and Method: This retrospective study was conducted on patients with the diagnosis of uterine carcinosarcomas and ovarian carcinosarcomas treated between January 1, 2006, and December 31, 2020. Records of 54 patients (42 patients with uterine carcinosarcoma and 12 patients with ovarian carcinosarcoma) who underwent debulking surgery were analyzed. Results: No difference was found in terms of mean tumor diameter, lymphovascular space invasion, lymph node involvement, and omental assessment. Recurrence occurred in 18 patients with uterine carcinosarcoma and eight patients with ovarian carcinosarcoma. Distant organ metastases such as lung or brain were not detected in any of the patients during the follow-ups. Kaplan'Meier analysis showed that disease-free survival (DFS) and overall survival (OS) in the uterine carcinosarcoma and ovarian carcinosarcoma groups were similar (p=0 .938 for OS and p=0.328 for DFS). Conclusion: Ovarian carcinosarcomas can be seen at an earlier age than uterine carcinosarcomas, and it has fewer signs that may indicate disease. It should be underlined that 41.7% of patients with ovarian carcinosarcoma were in the premenopausal period.","PeriodicalId":36268,"journal":{"name":"Journal of Clinical Obstetrics and Gynecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135600748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Adnexal torsion is one of the gynecological surgical emergencies that can be seen in women of all ages, with or without an ovarian cyst. In this study, it was aimed to investigate the effect of performing cystectomy on ovarian reserve in an ovary exposed to ischemia during emergency surgery in cases of adnexal torsion with an ovarian cyst, which is presumed to be benign. Material and Methods: The ovaries of nineteen women who underwent laparoscopic detorsion due to adnexal torsion (Group 1) and the ovaries of ten women who underwent laparoscopic detorsion+cystectomy in the same session with adnexal torsion due to a cyst, which was presumed to be benign (Group 2) were compared in terms of ovarian volume and antral follicular counts (AFC). Results: There was no statistically significant difference between the volumes and AFCs of the operated ovaries of the women in Group 1 (ovarian volume 11.56±9.58 cm3, AFC: 8.52±5.92 cm3) and the women in Group 2 (ovarian volume 10.99±5.07 cm3, AFC: 9.20±3.15 cm3) (p>0.05). Conclusion: Performing a cystectomy during detorsion surgery for a cyst presumed to be benign in a torsioned ovary exposed to ischemia does not seem to do any additional harm when evaluated in terms of AFC and volume.
{"title":"Effect of Simultaneous Cystectomy on Ovarian Reserve in Cases of Adnexal Torsion: A Prospective Case-Control Study","authors":"Nurşen KURTOĞLU AKSOY, Evrim Ebru KOVALAK, Mevlide ŞAN KARAMAN","doi":"10.5336/jcog.2023-97818","DOIUrl":"https://doi.org/10.5336/jcog.2023-97818","url":null,"abstract":"Objective: Adnexal torsion is one of the gynecological surgical emergencies that can be seen in women of all ages, with or without an ovarian cyst. In this study, it was aimed to investigate the effect of performing cystectomy on ovarian reserve in an ovary exposed to ischemia during emergency surgery in cases of adnexal torsion with an ovarian cyst, which is presumed to be benign. Material and Methods: The ovaries of nineteen women who underwent laparoscopic detorsion due to adnexal torsion (Group 1) and the ovaries of ten women who underwent laparoscopic detorsion+cystectomy in the same session with adnexal torsion due to a cyst, which was presumed to be benign (Group 2) were compared in terms of ovarian volume and antral follicular counts (AFC). Results: There was no statistically significant difference between the volumes and AFCs of the operated ovaries of the women in Group 1 (ovarian volume 11.56±9.58 cm3, AFC: 8.52±5.92 cm3) and the women in Group 2 (ovarian volume 10.99±5.07 cm3, AFC: 9.20±3.15 cm3) (p>0.05). Conclusion: Performing a cystectomy during detorsion surgery for a cyst presumed to be benign in a torsioned ovary exposed to ischemia does not seem to do any additional harm when evaluated in terms of AFC and volume.","PeriodicalId":36268,"journal":{"name":"Journal of Clinical Obstetrics and Gynecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135600749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: During the pandemic, pregnant women were more likely to develop severe illness, necessitating critical care, and require mechanical ventilation. Birth of the pregnant women can be necessary for the rapid decline in mother's clinical situation or for obstetric indication. This study aimed to investigate the clinical outcomes of pregnant women who gave birth during coronavirus disease-2019 (COVID-19) isolation period with regard to mode of birth and type of anesthesia in cesarean delivery. Material and Methods: The clinical outcomes of pregnant women who were admitted to the hospital, confirmed to be infected with severe acute respiratory syndrome-coronavirus-2, and gave birth during the hospitalization for COVID-19 treatment or isolation period between March, 2020 and November, 2021were analyzed according to mode of birth and type of anesthesia, retrospectively. Results: Among all pregnant women, 106 (%35.45) gave birth vaginally while 193 (64.55%) underwent cesarean section. Out of all cesarean births, 55 (28.5%) and out of all vaginal births, 2 (1.9%) had indication of birth as deterioration of maternal clinical status. Intensive care unit admission rate was 23.3%, maternal mortality rate was 11.9%, and preterm birth rate (
{"title":"Impact of Mode of Birth and Type of Anesthesia on Clinical Outcomes of Pregnant Women with COVID-19 in a Referral Pandemic Hospital: An Analytical Study","authors":"Gül ÇAVUŞOĞLU, Arzu Bilge TEKİN, Murat YASSA, Bilge DOĞAN TAYMUR, Pınar BİROL İLTER, Kübra KARAKOÇ, İlkyaz AKARSU BAŞOĞLU, Doğuş BUDAK, Emre YAVUZ, Güldeniz TOKLUCU, Niyazi TUĞ","doi":"10.5336/jcog.2023-96995","DOIUrl":"https://doi.org/10.5336/jcog.2023-96995","url":null,"abstract":"Objective: During the pandemic, pregnant women were more likely to develop severe illness, necessitating critical care, and require mechanical ventilation. Birth of the pregnant women can be necessary for the rapid decline in mother's clinical situation or for obstetric indication. This study aimed to investigate the clinical outcomes of pregnant women who gave birth during coronavirus disease-2019 (COVID-19) isolation period with regard to mode of birth and type of anesthesia in cesarean delivery. Material and Methods: The clinical outcomes of pregnant women who were admitted to the hospital, confirmed to be infected with severe acute respiratory syndrome-coronavirus-2, and gave birth during the hospitalization for COVID-19 treatment or isolation period between March, 2020 and November, 2021were analyzed according to mode of birth and type of anesthesia, retrospectively. Results: Among all pregnant women, 106 (%35.45) gave birth vaginally while 193 (64.55%) underwent cesarean section. Out of all cesarean births, 55 (28.5%) and out of all vaginal births, 2 (1.9%) had indication of birth as deterioration of maternal clinical status. Intensive care unit admission rate was 23.3%, maternal mortality rate was 11.9%, and preterm birth rate (","PeriodicalId":36268,"journal":{"name":"Journal of Clinical Obstetrics and Gynecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135601060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Cervical cancer and breast cancer are the leading causes of global cancer incidence in 2020. Despite being largely preventable, the burden of breast and cervical cancer is rising. Early detection reduces morbidity and mortality significantly, thus the role of screening is vital. Material and Methods: A cross-sectional study was conducted to know the knowledge, attitude and practices regarding breast and cervical cancer screening methods among female employees at our institute. Results: A total of 174 female employees participated in the study. 65.51% of the participants were more educated and 34.49% were less educated. 91.2% of more educated participants and 50% of less educated participants had knowledge about Pap smear. 64.6% had never had a Pap smear and only half of those who did undergo Pap testing had got it done within the preceding 5 years. 82.14% showed a positive attitude towards accepting a Pap smear. 92.9% had heard about breast cancer screening methods, 70.17% knew about the self-breast examination (SBE) and 50.87% knew about the clinical breast examination (CBE). Out of the participants who knew about SBE, 50% performed it and out of whom only 22.44% practiced it on a monthly basis. Similarly, 31.03% of total participants had ever got done CBE out of which only 22.22% used to do it on a yearly basis. Mammography was known by 72.6% of the participants who were above 40 years of age but only 28.89% had ever undergone it. Conclusion: The survey shows that there is a gap between knowledge, attitude, and practice.
{"title":"Knowledge, Attitude and Practices on Breast and Cervical Cancer Screening Methods Among Female Employees at the Gujarat Cancer and Research Institute, Ahmedabad: Analytical Research: Cross-Sectional Study","authors":"Nishu DHINGRA, Pariseema DAVE, Bijal PATEL","doi":"10.5336/jcog.2023-96549","DOIUrl":"https://doi.org/10.5336/jcog.2023-96549","url":null,"abstract":"Objective: Cervical cancer and breast cancer are the leading causes of global cancer incidence in 2020. Despite being largely preventable, the burden of breast and cervical cancer is rising. Early detection reduces morbidity and mortality significantly, thus the role of screening is vital. Material and Methods: A cross-sectional study was conducted to know the knowledge, attitude and practices regarding breast and cervical cancer screening methods among female employees at our institute. Results: A total of 174 female employees participated in the study. 65.51% of the participants were more educated and 34.49% were less educated. 91.2% of more educated participants and 50% of less educated participants had knowledge about Pap smear. 64.6% had never had a Pap smear and only half of those who did undergo Pap testing had got it done within the preceding 5 years. 82.14% showed a positive attitude towards accepting a Pap smear. 92.9% had heard about breast cancer screening methods, 70.17% knew about the self-breast examination (SBE) and 50.87% knew about the clinical breast examination (CBE). Out of the participants who knew about SBE, 50% performed it and out of whom only 22.44% practiced it on a monthly basis. Similarly, 31.03% of total participants had ever got done CBE out of which only 22.22% used to do it on a yearly basis. Mammography was known by 72.6% of the participants who were above 40 years of age but only 28.89% had ever undergone it. Conclusion: The survey shows that there is a gap between knowledge, attitude, and practice.","PeriodicalId":36268,"journal":{"name":"Journal of Clinical Obstetrics and Gynecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135600755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To establish a reference range for fetal ductus venosus pulsatility index for veins (DV PIV) and investigate the efficacy of the abnormal ductus venosus (DV) Doppler assessment to diagnose the chromosomal abnormalities of the fetus during first-trimester screening. Material and Methods: We retrospectively evaluated a total of 3,243 singleton pregnancies at 11+0 to 13+6 weeks of gestation in a 12-year period and assigned the patients into 2 groups to compare the efficacy of DV PIV in predicting chromosome abnormalities. The first group consisted of pregnancies involving fetuses with chromosomal abnormalities and the second group consisted of uncomplicated singleton fetuses with available DV Doppler measurements. We determined a cut-off value for DV PIV measurements to predict chromosomal abnormalities, and analyzed the relationship between chromosome abnormalities, and abnormal DV Doppler measurements. Results: A total of 644 fetuses (104 fetuses with an abnormal karyotype (pregnancies involving fetuses with chromosomal abnormalities) and 540 fetuses phenotypically normal or euploid in neonates after birth (pregnancies with normal fetuses) met the study criteria. The 5th and 95th percentiles of DV PIV were 0.78 and 1.21 in pregnancies with normal fetuses. We calculated with 63.6% sensitivity and 60.3% specificity, (95% confidence interval 0.72-0.83) for DV PIV to diagnose chromosomal abnormalities. Abnormal DV blood flow was related to all trisomies. The lowest DV PIV was observed in cases with trisomy 21, while the highest DV PIV values were found in cases with trisomy 18 and 13 in the abnormal karyotype group. Conclusion: Routinely monitoring DIV PIV as a first-trimester screening tool may be beneficial to predict fetal chromosomal abnormalities.
{"title":"The Predictive Values of Ductus Venosus Pulsatility Index and ''A Wave'' for Chromosomal Abnormalities","authors":"Şafak YILMAZ BARAN, Başar ÖNAL, Murat YAYLA","doi":"10.5336/jcog.2023-96258","DOIUrl":"https://doi.org/10.5336/jcog.2023-96258","url":null,"abstract":"Objective: To establish a reference range for fetal ductus venosus pulsatility index for veins (DV PIV) and investigate the efficacy of the abnormal ductus venosus (DV) Doppler assessment to diagnose the chromosomal abnormalities of the fetus during first-trimester screening. Material and Methods: We retrospectively evaluated a total of 3,243 singleton pregnancies at 11+0 to 13+6 weeks of gestation in a 12-year period and assigned the patients into 2 groups to compare the efficacy of DV PIV in predicting chromosome abnormalities. The first group consisted of pregnancies involving fetuses with chromosomal abnormalities and the second group consisted of uncomplicated singleton fetuses with available DV Doppler measurements. We determined a cut-off value for DV PIV measurements to predict chromosomal abnormalities, and analyzed the relationship between chromosome abnormalities, and abnormal DV Doppler measurements. Results: A total of 644 fetuses (104 fetuses with an abnormal karyotype (pregnancies involving fetuses with chromosomal abnormalities) and 540 fetuses phenotypically normal or euploid in neonates after birth (pregnancies with normal fetuses) met the study criteria. The 5th and 95th percentiles of DV PIV were 0.78 and 1.21 in pregnancies with normal fetuses. We calculated with 63.6% sensitivity and 60.3% specificity, (95% confidence interval 0.72-0.83) for DV PIV to diagnose chromosomal abnormalities. Abnormal DV blood flow was related to all trisomies. The lowest DV PIV was observed in cases with trisomy 21, while the highest DV PIV values were found in cases with trisomy 18 and 13 in the abnormal karyotype group. Conclusion: Routinely monitoring DIV PIV as a first-trimester screening tool may be beneficial to predict fetal chromosomal abnormalities.","PeriodicalId":36268,"journal":{"name":"Journal of Clinical Obstetrics and Gynecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135600757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The aim of this study was to compare the ovarian reserve tests and abnormal test results in couples with 2 to more than 2 recurrent pregnancy losses in our population. Material and Methods: Seventy-five couples aged 20-44 years, who had two or more consecutive abortions at 20 weeks or less from the last menstrual period, were included in the study. The women were divided into two groups as those who had two miscarriages (Group 1, n=34) and those who had three or more miscarriages (Group 2, n=41). Women in both groups were compared in terms of serum hormone levels, biochemical parameters, karyotype analysis, thrombophilic, and uterine factors. The spermiogram values and karyotype analyzes of the male partners in both groups were compared. Results: The women in Group 2 were older than those in Group 1, and live birth history and Factor V Leiden heterozygosity were found to be statistically significantly higher. The follicle stimulating hormone values in the secondary recurrent pregnancy loss patients were found to be statistically significantly higher than in the primary recurrent pregnancy loss patients. Conclusion: Maternal age and Factor V Leiden heterozygosity may be associated with the number of miscarriages in couples with recurrent pregnancy loss.
目的:本研究的目的是比较2次或2次以上复发妊娠失败夫妇的卵巢储备检查和异常检查结果。材料与方法:研究对象为75对年龄在20-44岁之间，在最后一次月经后20周或更短时间内连续两次或两次以上流产的夫妇。这些妇女被分为两组，一组有过两次流产(第1组，n=34)，另一组有过三次以上流产(第2组，n=41)。两组妇女在血清激素水平、生化参数、核型分析、血栓形成和子宫因素方面进行比较。比较两组男性伴侣的精子图值和核型分析。结果:2组妇女年龄大于1组，活产史和Factor V Leiden杂合性均有统计学意义。继发性复发性妊娠丢失患者的促卵泡激素值明显高于原发性复发性妊娠丢失患者。结论:母亲年龄和Leiden因子V杂合性可能与反复流产夫妇的流产次数有关。
{"title":"The Relationship Between the Number of Miscarriages and Diagnostic Parameters in Couples with Recurrent Pregnancy Loss: A Retrospective Cohort Study","authors":"Evrim Ebru KOVALAK, Özlem KARABAY AKGÜL, Nurşen KURTOĞLU AKSOY, Neşe HAYIRLIOĞLU, Erdal KAYA","doi":"10.5336/jcog.2023-95397","DOIUrl":"https://doi.org/10.5336/jcog.2023-95397","url":null,"abstract":"Objective: The aim of this study was to compare the ovarian reserve tests and abnormal test results in couples with 2 to more than 2 recurrent pregnancy losses in our population. Material and Methods: Seventy-five couples aged 20-44 years, who had two or more consecutive abortions at 20 weeks or less from the last menstrual period, were included in the study. The women were divided into two groups as those who had two miscarriages (Group 1, n=34) and those who had three or more miscarriages (Group 2, n=41). Women in both groups were compared in terms of serum hormone levels, biochemical parameters, karyotype analysis, thrombophilic, and uterine factors. The spermiogram values and karyotype analyzes of the male partners in both groups were compared. Results: The women in Group 2 were older than those in Group 1, and live birth history and Factor V Leiden heterozygosity were found to be statistically significantly higher. The follicle stimulating hormone values in the secondary recurrent pregnancy loss patients were found to be statistically significantly higher than in the primary recurrent pregnancy loss patients. Conclusion: Maternal age and Factor V Leiden heterozygosity may be associated with the number of miscarriages in couples with recurrent pregnancy loss.","PeriodicalId":36268,"journal":{"name":"Journal of Clinical Obstetrics and Gynecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135600747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To evaluate second trimester fetal nasal length measurement results in healthy singleton pregnancies in Turkey. Material and Methods: We analyzed the nasal bone lengths within 19-24 weeks in 661 pregnancies in our hospital. All pregnant women with a single healthy fetus who applied to our perinatology outpatient clinic for detailed obstetric ultrasonography were included in the study. All measurements were performed by the same clinician during routine mid-trimester ultrasound scan. Only the patients who were considered healthy by the examining pediatrician were included in the study. The parents of all fetuses are of Turkish ethnicity. Pearson correlation, regression analysis and P value were calculated between gestational week and nasal bone length. Results: Mean nasal length measurement was 6,21 ± 0,08; 6,66 ± 0,05; 6,88 ±0,05; 7,13 ± 0,08; 7,77 ± 0,11 and 8,33 ± 0,25 mm from 19 to 24 week of pregnancy, respectively. A significant positive correlation was observed between gestational week and nasal bone length. Normal values of nasal bone length measuremens are identified for each gestational weeks acoording to our data and previous 5 studies. Conclusion: In this study, we presented the data of our own center and the results obtained from other studies conducted in our country show significant differences. We are of the opinion that studies conducted by different researchers in different regions remain insufficient to reflect the nomogram of Turkish ethnic origin. For this purpose, multicenter studies are needed to cover the whole society.
{"title":"Second Trimester Fetal Nasal Bone Length Measurement: A Single Center Study and National Data Review","authors":"Nizamettin BOZBAY, Fazıl AVCI, Gökçen ÖRGÜL","doi":"10.5336/jcog.2023-95648","DOIUrl":"https://doi.org/10.5336/jcog.2023-95648","url":null,"abstract":"Objective: To evaluate second trimester fetal nasal length measurement results in healthy singleton pregnancies in Turkey. Material and Methods: We analyzed the nasal bone lengths within 19-24 weeks in 661 pregnancies in our hospital. All pregnant women with a single healthy fetus who applied to our perinatology outpatient clinic for detailed obstetric ultrasonography were included in the study. All measurements were performed by the same clinician during routine mid-trimester ultrasound scan. Only the patients who were considered healthy by the examining pediatrician were included in the study. The parents of all fetuses are of Turkish ethnicity. Pearson correlation, regression analysis and P value were calculated between gestational week and nasal bone length. Results: Mean nasal length measurement was 6,21 ± 0,08; 6,66 ± 0,05; 6,88 ±0,05; 7,13 ± 0,08; 7,77 ± 0,11 and 8,33 ± 0,25 mm from 19 to 24 week of pregnancy, respectively. A significant positive correlation was observed between gestational week and nasal bone length. Normal values of nasal bone length measuremens are identified for each gestational weeks acoording to our data and previous 5 studies. Conclusion: In this study, we presented the data of our own center and the results obtained from other studies conducted in our country show significant differences. We are of the opinion that studies conducted by different researchers in different regions remain insufficient to reflect the nomogram of Turkish ethnic origin. For this purpose, multicenter studies are needed to cover the whole society.","PeriodicalId":36268,"journal":{"name":"Journal of Clinical Obstetrics and Gynecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135601063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Juan MATZUMURA KASANO, Hugo GUTIERREZ CRESPO, Isabel Julia ALAMO PALOMINO
Objective: To analyze vaginal health based on three dimensions: symptoms, information, and treatment in menopausal Peruvian women attended in first level health care facilities. Material and Methods: This is a descriptive, prospective, cross-sectional research, with the participation of women attended in first level health care facilities during the year 2021. A non-probability sample of 855 women was used. A vaginal health survey composed of 26 indicators was used through 3 dimensions: symptoms, information, and treatment, with a reliability coefficient of 0.79. Results: The mean age was 54.8±6.4 years, 67.8% had no knowledge of hormone therapy for menopause, while 80.9% said they did not use it. In the symptoms dimension: 22.6% experienced hot flashes frequently and 15.2% had vaginal symptoms (dryness, burning, and soreness), 54.9% considered them as a mild discomfort and described the symptoms as part of aging. In the information dimension: 60.4% stated that there is not enough information; 44.6% of women have access to information through their gynecologists, and 46.9% feel comfortable asking about treatment options. In the treatment dimension: 39.2% consider hormonal vaginal suppositories as an effective treatment; 23.5% did not use any treatment; and 73.8% would consider using hormone therapy during menopause. Conclusion: There was a high prevalence of vasomotor and vaginal symptoms affecting quality of life. The information given to patients was insufficient despite being provided by the gynecologist. There is acceptance for the use of local estrogen therapy.
{"title":"Vaginal Health in Menopausal Peruvian Women: Descriptive Research","authors":"Juan MATZUMURA KASANO, Hugo GUTIERREZ CRESPO, Isabel Julia ALAMO PALOMINO","doi":"10.5336/jcog.2023-96111","DOIUrl":"https://doi.org/10.5336/jcog.2023-96111","url":null,"abstract":"Objective: To analyze vaginal health based on three dimensions: symptoms, information, and treatment in menopausal Peruvian women attended in first level health care facilities. Material and Methods: This is a descriptive, prospective, cross-sectional research, with the participation of women attended in first level health care facilities during the year 2021. A non-probability sample of 855 women was used. A vaginal health survey composed of 26 indicators was used through 3 dimensions: symptoms, information, and treatment, with a reliability coefficient of 0.79. Results: The mean age was 54.8±6.4 years, 67.8% had no knowledge of hormone therapy for menopause, while 80.9% said they did not use it. In the symptoms dimension: 22.6% experienced hot flashes frequently and 15.2% had vaginal symptoms (dryness, burning, and soreness), 54.9% considered them as a mild discomfort and described the symptoms as part of aging. In the information dimension: 60.4% stated that there is not enough information; 44.6% of women have access to information through their gynecologists, and 46.9% feel comfortable asking about treatment options. In the treatment dimension: 39.2% consider hormonal vaginal suppositories as an effective treatment; 23.5% did not use any treatment; and 73.8% would consider using hormone therapy during menopause. Conclusion: There was a high prevalence of vasomotor and vaginal symptoms affecting quality of life. The information given to patients was insufficient despite being provided by the gynecologist. There is acceptance for the use of local estrogen therapy.","PeriodicalId":36268,"journal":{"name":"Journal of Clinical Obstetrics and Gynecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135601059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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