Pub Date : 2020-01-13DOI: 10.1007/s40473-020-00197-3
A. El-Ansary, R. Bhat, N. Zayed
{"title":"Gut Microbiome and Sex Bias in Autism Spectrum Disorders","authors":"A. El-Ansary, R. Bhat, N. Zayed","doi":"10.1007/s40473-020-00197-3","DOIUrl":"https://doi.org/10.1007/s40473-020-00197-3","url":null,"abstract":"","PeriodicalId":36384,"journal":{"name":"Current Behavioral Neuroscience Reports","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2020-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40473-020-00197-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49195608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-07DOI: 10.1007/s40473-020-00199-1
D. Inta, B. Wölnerhanssen, A. C. Meyer-Gerspach, Elisabeth Lang, N. Schweinfurth, A. Mallien, A. Vasilescu, A. Schmidt, K. Rea, A. Westendorf, M. Tremblay, A. Sartorius, P. Gass, J. Cryan, S. Borgwardt, U. Lang
{"title":"Common Pathways in Depression and Obesity: The Role of Gut Microbiome and Diets","authors":"D. Inta, B. Wölnerhanssen, A. C. Meyer-Gerspach, Elisabeth Lang, N. Schweinfurth, A. Mallien, A. Vasilescu, A. Schmidt, K. Rea, A. Westendorf, M. Tremblay, A. Sartorius, P. Gass, J. Cryan, S. Borgwardt, U. Lang","doi":"10.1007/s40473-020-00199-1","DOIUrl":"https://doi.org/10.1007/s40473-020-00199-1","url":null,"abstract":"","PeriodicalId":36384,"journal":{"name":"Current Behavioral Neuroscience Reports","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2020-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40473-020-00199-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44997723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-01Epub Date: 2019-12-02DOI: 10.1007/s40473-019-00184-3
Manivel Rengasamy, Kimberly Hsiung, Rebecca B Price
Purpose of review: Given recent increases in rates of suicide and lack of rapid treatments for suicidality, ketamine has been identified as a potential fast-acting anti-suicidal treatment. Our review seeks to describe the effects of ketamine on suicidality, given the growing literature on the use of ketamine in reducing suicidality. We examine open-label studies and randomized controlled trials evaluating treatment of suicidality with ketamine. Furthermore, our manuscript identifies potential mechanisms of ketamine's effects on suicidality.
Recent findings: Based on existing RCTs, ketamine appears to have rapid anti-suicidal effects, with most literature studying such effects in timeframes less than one week. Although still in the early stages of research, mechanisms of ketamine include modulation of molecular, inflammatory, neural, cognitive, and behavioral processes.
Summary: Thus, ketamine appears to be a promising treatment for suicidality, but requires larger scale and more robust RCTs to confirm the potential use of this agent in clinical settings.
{"title":"Infusing hope into the treatment of suicidality: A review of ketamine's effects on suicidality.","authors":"Manivel Rengasamy, Kimberly Hsiung, Rebecca B Price","doi":"10.1007/s40473-019-00184-3","DOIUrl":"10.1007/s40473-019-00184-3","url":null,"abstract":"<p><strong>Purpose of review: </strong>Given recent increases in rates of suicide and lack of rapid treatments for suicidality, ketamine has been identified as a potential fast-acting anti-suicidal treatment. Our review seeks to describe the effects of ketamine on suicidality, given the growing literature on the use of ketamine in reducing suicidality. We examine open-label studies and randomized controlled trials evaluating treatment of suicidality with ketamine. Furthermore, our manuscript identifies potential mechanisms of ketamine's effects on suicidality.</p><p><strong>Recent findings: </strong>Based on existing RCTs, ketamine appears to have rapid anti-suicidal effects, with most literature studying such effects in timeframes less than one week. Although still in the early stages of research, mechanisms of ketamine include modulation of molecular, inflammatory, neural, cognitive, and behavioral processes.</p><p><strong>Summary: </strong>Thus, ketamine appears to be a promising treatment for suicidality, but requires larger scale and more robust RCTs to confirm the potential use of this agent in clinical settings.</p>","PeriodicalId":36384,"journal":{"name":"Current Behavioral Neuroscience Reports","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809881/pdf/nihms-1544964.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38828558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-01Epub Date: 2019-11-06DOI: 10.1007/s40473-019-00194-1
Jeremy G Stewart, Lillian Polanco-Roman, Cristiane S Duarte, Randy P Auerbach
Purpose of review: Identifying risk factors for STBs during adolescence is essential for suicide prevention. In this review, we employ the Research Domain Criteria (RDoC) framework to synthesize studies on key neurocognitive processes-cognitive control, reward responsiveness/valuation, and negative urgency-relevant to adolescent STBs.
Recent findings: Within subdomains of Cognitive Control, studies of inhibition/suppression and updating/maintenance were mixed, while response selection (i.e., decision-making) deficits were consistently associated with suicide attempts. Fewer studies, by comparison, have probed the Positive Valence Systems. Relative to healthy controls, adolescents with prior STBs may show a blunted neural response to rewards and value rewards less, but findings require replication. Finally, negative urgency, which may span subdomains within both Cognitive Control and the Positive Valence Systems, was associated with recent suicide attempts in the only study to directly test this association.
Summary: Few studies have examined neurocognitive functioning in relation to adolescent STBs, despite the relevance of this research to detecting suicide risk. We recommend that future studies incorporate developmental contexts relevant to both neurocognitive processes and STBs.Broadly, cognitive control is associated with activation of the prefrontal cortex (PFC) and its interaction with other brain areas (e.g., reward and motor regions) [32]. Functional magnetic resonance imaging (fMRI) studies using emotional stimuli have provided evidence of abnormalities in neural regions supporting cognitive control among youth with STBs. [33] computed neural activation corresponding to viewing angry faces (relative to a fixation cross) in a sample of depressed youth. They found that, relative to non-attempters, attempters had: (a) increased activation in the right anterior gyrus and dorsolateral PFC and (b) reduced functional connectivity between the anterior cingulate gyrus and bilateral insulae. Relatedly, youth with bipolar disorder and a history of suicide attempts showed reduced functional connectivity between the amygdala and the left ventral PFC while viewing emotional (happy, fearful) and neutral faces compared to patient non-attempters [34]. The findings indicate that attempters may have problems regulating and appropriately deploying attention, as well as planning and executing behavioral responses, in emotional contexts.
{"title":"Neurocognitive Processes Implicated in Adolescent Suicidal Thoughts and Behaviors: Applying an RDoC Framework for Conceptualizing Risk.","authors":"Jeremy G Stewart, Lillian Polanco-Roman, Cristiane S Duarte, Randy P Auerbach","doi":"10.1007/s40473-019-00194-1","DOIUrl":"https://doi.org/10.1007/s40473-019-00194-1","url":null,"abstract":"<p><strong>Purpose of review: </strong>Identifying risk factors for STBs during adolescence is essential for suicide prevention. In this review, we employ the Research Domain Criteria (RDoC) framework to synthesize studies on key neurocognitive processes-cognitive control, reward responsiveness/valuation, and negative urgency-relevant to adolescent STBs.</p><p><strong>Recent findings: </strong>Within subdomains of Cognitive Control, studies of inhibition/suppression and updating/maintenance were mixed, while response selection (i.e., decision-making) deficits were consistently associated with suicide attempts. Fewer studies, by comparison, have probed the Positive Valence Systems. Relative to healthy controls, adolescents with prior STBs may show a blunted neural response to rewards and value rewards less, but findings require replication. Finally, negative urgency, which may span subdomains within both Cognitive Control and the Positive Valence Systems, was associated with recent suicide attempts in the only study to directly test this association.</p><p><strong>Summary: </strong>Few studies have examined neurocognitive functioning in relation to adolescent STBs, despite the relevance of this research to detecting suicide risk. We recommend that future studies incorporate developmental contexts relevant to both neurocognitive processes and STBs.Broadly, cognitive control is associated with activation of the prefrontal cortex (PFC) and its interaction with other brain areas (e.g., reward and motor regions) [32]. Functional magnetic resonance imaging (fMRI) studies using emotional stimuli have provided evidence of abnormalities in neural regions supporting cognitive control among youth with STBs. [33] computed neural activation corresponding to viewing angry faces (relative to a fixation cross) in a sample of depressed youth. They found that, relative to non-attempters, attempters had: (a) increased activation in the right anterior gyrus and dorsolateral PFC and (b) reduced functional connectivity between the anterior cingulate gyrus and bilateral insulae. Relatedly, youth with bipolar disorder and a history of suicide attempts showed reduced functional connectivity between the amygdala and the left ventral PFC while viewing emotional (happy, fearful) and neutral faces compared to patient non-attempters [34]. The findings indicate that attempters may have problems regulating and appropriately deploying attention, as well as planning and executing behavioral responses, in emotional contexts.</p>","PeriodicalId":36384,"journal":{"name":"Current Behavioral Neuroscience Reports","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40473-019-00194-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38705589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-08DOI: 10.1007/s40473-019-00196-z
Lisa N. Cruz, Jill Del Pozzo, Taylor Zar, M. Hansen
{"title":"Phenomenology of Voice-Hearing in Psychosis Spectrum Disorders: a Review of Neural Mechanisms","authors":"Lisa N. Cruz, Jill Del Pozzo, Taylor Zar, M. Hansen","doi":"10.1007/s40473-019-00196-z","DOIUrl":"https://doi.org/10.1007/s40473-019-00196-z","url":null,"abstract":"","PeriodicalId":36384,"journal":{"name":"Current Behavioral Neuroscience Reports","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2019-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40473-019-00196-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47106146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-07DOI: 10.1007/s40473-019-00193-2
Richard G. Hersh, Benjamin McCommon, Emma G. Golkin
{"title":"Sharing a Diagnosis of Narcissistic Personality: a Challenging Decision with Associated Risks and Benefits","authors":"Richard G. Hersh, Benjamin McCommon, Emma G. Golkin","doi":"10.1007/s40473-019-00193-2","DOIUrl":"https://doi.org/10.1007/s40473-019-00193-2","url":null,"abstract":"","PeriodicalId":36384,"journal":{"name":"Current Behavioral Neuroscience Reports","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2019-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40473-019-00193-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43776029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-07DOI: 10.1007/s40473-019-00195-0
C. McClintock, P. Worhunsky, I. Balodis, R. Sinha, L. Miller, M. Potenza
{"title":"How Spirituality May Mitigate Against Stress and Related Mental Disorders: a Review and Preliminary Neurobiological Evidence","authors":"C. McClintock, P. Worhunsky, I. Balodis, R. Sinha, L. Miller, M. Potenza","doi":"10.1007/s40473-019-00195-0","DOIUrl":"https://doi.org/10.1007/s40473-019-00195-0","url":null,"abstract":"","PeriodicalId":36384,"journal":{"name":"Current Behavioral Neuroscience Reports","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2019-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40473-019-00195-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46209681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-25DOI: 10.1007/s40473-019-00192-3
Malosree Maitra, C. Nagy, G. Turecki
{"title":"Sequencing the Human Brain at Single-Cell Resolution","authors":"Malosree Maitra, C. Nagy, G. Turecki","doi":"10.1007/s40473-019-00192-3","DOIUrl":"https://doi.org/10.1007/s40473-019-00192-3","url":null,"abstract":"","PeriodicalId":36384,"journal":{"name":"Current Behavioral Neuroscience Reports","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2019-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40473-019-00192-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43786254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-07DOI: 10.1007/s40473-019-00190-5
Kiran Punia, I. Balodis
{"title":"An Overview of the Neurobiology of Impulsivity in Gambling and Gaming Disorder","authors":"Kiran Punia, I. Balodis","doi":"10.1007/s40473-019-00190-5","DOIUrl":"https://doi.org/10.1007/s40473-019-00190-5","url":null,"abstract":"","PeriodicalId":36384,"journal":{"name":"Current Behavioral Neuroscience Reports","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2019-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40473-019-00190-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42496603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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