Pub Date : 2019-09-07DOI: 10.1007/s40473-019-00190-5
Kiran Punia, I. Balodis
{"title":"An Overview of the Neurobiology of Impulsivity in Gambling and Gaming Disorder","authors":"Kiran Punia, I. Balodis","doi":"10.1007/s40473-019-00190-5","DOIUrl":"https://doi.org/10.1007/s40473-019-00190-5","url":null,"abstract":"","PeriodicalId":36384,"journal":{"name":"Current Behavioral Neuroscience Reports","volume":"6 1","pages":"209 - 218"},"PeriodicalIF":1.7,"publicationDate":"2019-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40473-019-00190-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42496603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-06DOI: 10.1007/s40473-019-00189-y
K. J. Allen, Melanie L. Bozzay, Emma R. Edenbaum
{"title":"Neurocognition and Suicide Risk in Adults","authors":"K. J. Allen, Melanie L. Bozzay, Emma R. Edenbaum","doi":"10.1007/s40473-019-00189-y","DOIUrl":"https://doi.org/10.1007/s40473-019-00189-y","url":null,"abstract":"","PeriodicalId":36384,"journal":{"name":"Current Behavioral Neuroscience Reports","volume":"6 1","pages":"151 - 165"},"PeriodicalIF":1.7,"publicationDate":"2019-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40473-019-00189-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45913393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-01Epub Date: 2019-07-05DOI: 10.1007/s40473-019-00182-5
Helena J V Rutherford, Jiansong Xu, Patrick D Worhunsky, Rubin Zhang, Sarah W Yip, Kristen P Morie, Vince D Calhoun, Sohye Kim, Lane Strathearn, Linda C Mayes, Marc N Potenza
Purpose of review: Parental brain research primarily employs general-linear-model-based (GLM-based) analyses to assess blood-oxygenation-level-dependent responses to infant auditory and visual cues, reporting common responses in shared cortical and subcortical structures. However, this approach does not reveal intermixed neural substrates related to different sensory modalities. We consider this notion in studying the parental brain.
Recent findings: Spatial independent component analysis (sICA) has been used to separate mixed source signals from overlapping functional networks. We explore relative differences between GLM-based analysis and sICA as applied to an fMRI dataset acquired from women while they listened to infant cries or viewed infant sad faces.
Summary: There is growing appreciation for the value of moving beyond GLM-based analyses to consider brain functional organization as continuous, distributive, and overlapping gradients of neural substrates related to different sensory modalities. Preliminary findings suggest sICA can be applied to the study of the parental brain.
{"title":"Gradient theories of brain activation: A novel application to studying the parental brain.","authors":"Helena J V Rutherford, Jiansong Xu, Patrick D Worhunsky, Rubin Zhang, Sarah W Yip, Kristen P Morie, Vince D Calhoun, Sohye Kim, Lane Strathearn, Linda C Mayes, Marc N Potenza","doi":"10.1007/s40473-019-00182-5","DOIUrl":"10.1007/s40473-019-00182-5","url":null,"abstract":"<p><strong>Purpose of review: </strong>Parental brain research primarily employs general-linear-model-based (GLM-based) analyses to assess blood-oxygenation-level-dependent responses to infant auditory and visual cues, reporting common responses in shared cortical and subcortical structures. However, this approach does not reveal intermixed neural substrates related to different sensory modalities. We consider this notion in studying the parental brain.</p><p><strong>Recent findings: </strong>Spatial independent component analysis (sICA) has been used to separate mixed source signals from overlapping functional networks. We explore relative differences between GLM-based analysis and sICA as applied to an fMRI dataset acquired from women while they listened to infant cries or viewed infant sad faces.</p><p><strong>Summary: </strong>There is growing appreciation for the value of moving beyond GLM-based analyses to consider brain functional organization as continuous, distributive, and overlapping gradients of neural substrates related to different sensory modalities. Preliminary findings suggest sICA can be applied to the study of the parental brain.</p>","PeriodicalId":36384,"journal":{"name":"Current Behavioral Neuroscience Reports","volume":"6 3","pages":"119-125"},"PeriodicalIF":2.1,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062306/pdf/nihms-1533810.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37722630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-29DOI: 10.1007/s40473-019-00188-z
Melinda Westlund Schreiner, B. Klimes-Dougan, Anna M. Parenteau, Dawson C. Hill, Kathryn R. Cullen
{"title":"A Framework for Identifying Neurobiologically Based Intervention Targets for NSSI","authors":"Melinda Westlund Schreiner, B. Klimes-Dougan, Anna M. Parenteau, Dawson C. Hill, Kathryn R. Cullen","doi":"10.1007/s40473-019-00188-z","DOIUrl":"https://doi.org/10.1007/s40473-019-00188-z","url":null,"abstract":"","PeriodicalId":36384,"journal":{"name":"Current Behavioral Neuroscience Reports","volume":"6 1","pages":"177 - 187"},"PeriodicalIF":1.7,"publicationDate":"2019-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40473-019-00188-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42869297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-23Epub Date: 2019-08-02DOI: 10.1253/circj.CJ-19-0153
Lei Xu, Yi-Ru Wang, Pei-Cheng Li, Bo Feng
Background: There is accumulating evidence that the AGEs-RAGE interaction plays an important role in accelerated atherosclerosis in diabetes. Our previous study showed that the AGEs-RAGE axis can reduce the cholesterol efflux of THP-1 macrophages through suppression of the expression of ABCG1 and that statins can inhibit the expression of RAGE. However, the role of statins in recovering the cholesterol efflux of macrophages reduced by AGEs has not been assessed.
Methods and results: ApoE-/-mice and THP-1 macrophages were both treated by AGEs or AGEs combined with anti-RAGE antibody (only in THP-1 cells), ALT711 and atorvastatin separately. Cholesterol efflux of THP-1 macrophages and murine peritoneal macrophages was tested by fluorescence microplate technique. RT-PCR and western blot analysis were used to measure the expression of RAGE and molecules included in cholesterol efflux. After co-incubating with atorvastatin and AGEs, reduction in lipid accumulation in THP-1 macrophages and improvement of lesions complexity occurred compared with treating by AGEs only. Atorvastatin increased cholesterol efflux and ABCG1 expression of macrophages, which were reduced by AGEs, and decreased the expression of RAGE at the same time.
Conclusions: This study demonstrated that atorvastatin can recover the deleterious ABCG1-mediated cholesterol efflux induced by AGEs in THP-1 macrophages and murine peritoneal macrophages by downregulating RAGE expression. It may contribute to the protective action of atorvastatin in diabetic subjects with atherosclerosis.
{"title":"Atorvastatin Blocks Advanced Glycation End Products Induced Reduction in Macrophage Cholesterol Efflux Mediated With ATP-Binding Cassette Transporters G 1.","authors":"Lei Xu, Yi-Ru Wang, Pei-Cheng Li, Bo Feng","doi":"10.1253/circj.CJ-19-0153","DOIUrl":"10.1253/circj.CJ-19-0153","url":null,"abstract":"<p><strong>Background: </strong>There is accumulating evidence that the AGEs-RAGE interaction plays an important role in accelerated atherosclerosis in diabetes. Our previous study showed that the AGEs-RAGE axis can reduce the cholesterol efflux of THP-1 macrophages through suppression of the expression of ABCG1 and that statins can inhibit the expression of RAGE. However, the role of statins in recovering the cholesterol efflux of macrophages reduced by AGEs has not been assessed.</p><p><strong>Methods and results: </strong>ApoE<sup>-/-</sup>mice and THP-1 macrophages were both treated by AGEs or AGEs combined with anti-RAGE antibody (only in THP-1 cells), ALT711 and atorvastatin separately. Cholesterol efflux of THP-1 macrophages and murine peritoneal macrophages was tested by fluorescence microplate technique. RT-PCR and western blot analysis were used to measure the expression of RAGE and molecules included in cholesterol efflux. After co-incubating with atorvastatin and AGEs, reduction in lipid accumulation in THP-1 macrophages and improvement of lesions complexity occurred compared with treating by AGEs only. Atorvastatin increased cholesterol efflux and ABCG1 expression of macrophages, which were reduced by AGEs, and decreased the expression of RAGE at the same time.</p><p><strong>Conclusions: </strong>This study demonstrated that atorvastatin can recover the deleterious ABCG1-mediated cholesterol efflux induced by AGEs in THP-1 macrophages and murine peritoneal macrophages by downregulating RAGE expression. It may contribute to the protective action of atorvastatin in diabetic subjects with atherosclerosis.</p>","PeriodicalId":36384,"journal":{"name":"Current Behavioral Neuroscience Reports","volume":"6 1","pages":"1954-1964"},"PeriodicalIF":3.1,"publicationDate":"2019-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89962050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-14DOI: 10.1007/s40473-019-00183-4
V. Hong, Loreen F Pirnie, A. Shobassy
{"title":"Antisocial and Borderline Personality Disorders in the Emergency Department: Conceptualizing and Managing “Malingered” or “Exaggerated” Symptoms","authors":"V. Hong, Loreen F Pirnie, A. Shobassy","doi":"10.1007/s40473-019-00183-4","DOIUrl":"https://doi.org/10.1007/s40473-019-00183-4","url":null,"abstract":"","PeriodicalId":36384,"journal":{"name":"Current Behavioral Neuroscience Reports","volume":"6 1","pages":"127 - 132"},"PeriodicalIF":1.7,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40473-019-00183-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44333715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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