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The mechanical characteristics and early-stage clinical effects of double bundle anterior cruciate ligament reconstruction with femoral direct fiber insertion 股纤维直接插入双束前交叉韧带重建术的力学特点及早期临床效果
Q4 Medicine Pub Date : 2020-04-01 DOI: 10.3760/CMA.J.CN121113-20200225-00103
Xian-Xiang Xiang, Chungang Zhang, Weiming Wang
Objective To investigate the finite element analysis and early-stage clinical effects of double bundle anterior cruciate ligament (ACL) reconstruction with femoral direct fiber insertion. Methods From June 2016 to June 2017, a total of 26 cases of ACL reconstruction were analyzed retrospectively, including 15 males and 11 females, mean age 30.5±4.6 years. All the patients underwent ACL reconstruction by the same operator. The early-stage clinical effects were evaluated by the finite element analysis, pivot shift test, Lachman test, preoperative and postoperative IKDC score, Lyshlom score, KT-2000, 3D-CT and MRI. Results The finite element analysis confirmed theoretically that the double bundle ACL reconstruction with femoral direct fiber insertion could restore the stability and biomechanics of knee effectively. The results of pivot shift test were negative, and the Lachman test were negative except one first-stage positive after operation. 3D-CT showed that the bone tunnel was located in the direct fiber area. MRI showed clearly the ACL of double bundle after operation. Lysholm score increased from 56.5±3.6 pre-operation to 61.9±3.2 at three months after operation, and up to 88.5±2.0 two years after operation with statistically significant difference (F=824.72, P<0.001). IKDC score increased from 48.3±2.8 before operation to 58.0±2.0 at three months after operation, and to 92.5±2.6 at two years after operation with statistically significant difference (F=2 256.66, P<0.001). KT-2000 side-side difference decreased from 5.6±0.7 mm to 1.6±0.5 mm at three months after operation, and to 1.5±0.6 mm at two years after operation with statistically significant difference (F=389.14, P<0.001). Conclusion The double bundle ACL reconstruction with femoral direct fiber insertion can effectively restore the stability and the biomechanical environment of knee joint with satisfied early-stage clinical effects. Key words: Anterior cruciate ligament; Reconstructive surgical procedures; Finite element analysis
目的探讨股纤维直接插入双束前交叉韧带重建的有限元分析及早期临床效果。方法回顾性分析2016年6月至2017年6月26例ACL重建患者,其中男性15例,女性11例,平均年龄30.5±4.6岁。所有患者均由同一术者进行ACL重建。采用有限元分析、pivot shift试验、Lachman试验、术前术后IKDC评分、Lyshlom评分、KT-2000、3D-CT和MRI评价早期临床效果。结果有限元分析从理论上证实股纤维直接插入双束前交叉韧带重建能有效恢复膝关节的稳定性和生物力学性能。除1例术后一期阳性外,枢轴移位试验均为阴性,Lachman试验均为阴性。3D-CT显示骨隧道位于直达纤维区。术后MRI显示双束前交叉韧带清晰。Lysholm评分由术前的56.5±3.6升至术后3个月的61.9±3.2,术后2年升至88.5±2.0,差异有统计学意义(F=824.72, P<0.001)。IKDC评分由术前48.3±2.8分增至术后3个月时的58.0±2.0分,术后2年的92.5±2.6分,差异均有统计学意义(F=2 256.66, P<0.001)。术后3个月KT-2000侧侧差由5.6±0.7 mm降至1.6±0.5 mm,术后2年降至1.5±0.6 mm,差异均有统计学意义(F=389.14, P<0.001)。结论股纤维直接插入双束前交叉韧带重建能有效恢复膝关节的稳定性和生物力学环境,早期临床效果满意。关键词:前交叉韧带;重建外科手术;有限元分析
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引用次数: 0
The comparison of clinical outcomes of popliteal tendon recess and reconstruction technique 腘肌腱隐窝与重建技术的临床疗效比较
Q4 Medicine Pub Date : 2020-04-01 DOI: 10.3760/CMA.J.CN121113-20200225-00099
Yue Li, Hui Zhang
Objective To compare the objective and subjective clinical outcomes of recess procedure versus popliteal tendon reconstruction in patients with posterolateral corner injury. Methods From January 2012 to January 2017, patients who were eligible for inclusion in this study if they 1) had acute posterolateral rotational instability (PLRI) and were treated surgically in our institution, 2) were followed for a minimum of 2 years with examination under anesthesia results. The mean age was 34.5±7.4 years (range 20-45 years). According to Fanelli's classification, there were 31 type A, 17 type B and 6 type C cases. There were 26 patients in reconstruction group and 28 patients in recess group. Outcomes included subjective scoring systems (Lysholm score, Tegner score and International Knee Documentation Committee (IKDC) subjective score), knee stability examinations (the side-to-side difference (SSD) of tibial external rotation angle by dial test, posterior and varus stress radiograph) and second-look arthroscopic lateral gutter drive-through test during hardware removal operation. Results The mean follow-up duration was 30.2±4.9 months in reconstruction group and 32.2±9.9 months in recess group. At the final follow-up, there were no significant differences in Lysholm scores (reconstruction group: 70.1±15.5, recess group: 70.0±10.2; t=0.089, P=0.926), Tegner scores (reconstruction group: 3(2, 5), recess group: 2(1, 4); U=395.522, P=0.156), or IKDC subjective scores (reconstruction group: 74.8±19.3, recess group: 71.2±17.6; t=0.381, P=0.722) between the groups. No significant difference in SSD on posterior stress radiography (reconstruction group: 4.1±3.4 mm, recess group: 4.7±2.6 mm; t=0.918, P=0.345) or medial stress radiography (reconstruction group: 4.0±1.7 mm, recess group: 3.8±1.9 mm; t=0.208, P=0.820) was observed. There was no significant difference on SSD of dial test (reconstruction group: 1.5°±4.2°, recess group: 1.1°±4.0°, t=0.586, P=0.565). No positive lateral gutter drive-through test was observed in all groups. Conclusion Both recess procedure and popliteal tendon reconstructions significantly improve the knee stability and subjective outcomes of patients with PLRI. In a comparison with popliteal tendon reconstruction, the recess procedure has similar subjective and objective clinical outcomes. Key words: Collateral ligaments; Tendon injuries; Arthroscopy; Reconstructive surgical procedures
目的比较腘腱重建术与隐窝手术治疗后外侧角损伤的客观和主观疗效。方法从2012年1月至2017年1月,符合纳入本研究条件的患者,如果他们1)患有急性后外侧旋转不稳定(PLRI)并在我们机构接受了手术治疗,2)在麻醉下进行了至少2年的随访,并取得了检查结果。平均年龄34.5±7.4岁(20~45岁)。根据Fanelli的分类,A型31例,B型17例,C型6例。重建组26例,隐窝组28例。结果包括主观评分系统(Lysholm评分、Tegner评分和国际膝关节文献委员会(IKDC)主观评分)、膝关节稳定性检查(通过刻度盘测试、后部和内翻应力片测量胫骨外旋角的侧差(SSD))和硬件移除操作期间的第二次关节镜下侧沟穿透测试。结果重建组平均随访时间为30.2±4.9个月,休会组为32.2±9.9个月。在最后的随访中,Lysholm评分(重建组:70.1±15.5,隐窝组:70.0±10.2;t=0.089,P=0.926)、Tegner评分(重建小组:3(2,5),隐窝小组:2(1,4);U=395.522,P=0.156),或IKDC主观评分(重建组:74.8±19.3,休会组:71.2±17.6;t=0.381,P=0.722)。SSD在后应力片(重建组:4.1±3.4mm,隐窝组:4.7±2.6mm;t=0.918,P=0.345)和内侧应力片上(重建组,4.0±1.7mm,隐凹组,3.8±1.9mm;t=0.208,P=0.820)无显著差异。刻度盘试验SSD无显著性差异(重建组:1.5°±4.2°,隐窝组:1.1°±4.0°,t=0.586,P=0.565),各组均未观察到侧沟穿通试验阳性。结论隐窝手术和腘腱重建均能显著改善PLRI患者的膝关节稳定性和主观疗效。与腘肌腱重建相比,隐窝手术具有相似的主观和客观临床结果。关键词:副韧带;肌腱损伤;关节镜检查;重建外科手术
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引用次数: 0
Short-term outcomes after lateral meniscus posterior root repairs in patients undergoing anterior cruciate ligament reconstructions 前交叉韧带重建患者外侧半月板后根修复后的短期疗效
Q4 Medicine Pub Date : 2020-04-01 DOI: 10.3760/CMA.J.CN121113-20200224-00094
Tong Zheng, H. Feng, Hui Zhang, Guan-yang Song, Yue Li, ZhiJun Zhang, Qian-kun Ni, Yan-wei Cao
Objective To evaluate the clinical, radiological and arthroscopic outcomes after surgical repair for chronic lateral meniscus posterior root (LMPR) avulsion combined with anterior cruciate ligament (ACL) reconstruction. Methods From July 2015 to June 2017, a total of 33 patients who underwent transtibial pull-out suture repair for chronic LMPR avulsion combined with anatomic single-bundle ACL reconstruction with hamstring graft were retrospectively reviewed. There were 30 males and 3 females with an average age of 27.7±7.5 years (range 17-45 years) and a mean BMI of 25.2±3.7 kg/m2 (range 19.4-36.7 kg/m2). All patients were available for at least two years of follow-up. A second-look arthroscopy was performed to evaluate the healing status of the repaired meniscus. Subjective knee function was assessed through Lysholm and Tegner scores. Objective knee stability was evaluated using KT-1000 arthrometer side-to-side difference (SSD) and pivot shift test under anesthesia. The tibiofemoral relationship was evaluated by anterior tibial subluxation (ATS) measured on axial MRI. Between patients with preoperative ATS ≥6 mm (18 patients in the ATS positive group) and <6 mm (15 patients in the ATS negative group), the postoperative ATS and the reduction of ATS was also compared. Results After a mean follow-up of 27.5±4.0 months (range 24-39 months), the LMPR avulsion completely healed in 23 (70%) cases, partially healed in 9 (27%) cases, failed to heal in 1 (3%) case on second-look arthroscopy. The Lysholm score was increased from 60.4±13.6 to 82.7±11.1 at 1 year and to 91.4±9.1 at 2 years operatively (F=155.996, P<0.001). The Tegner score was increased from 3(2, 5) to 4(3, 5) at 1 year and 6(4, 6) at 2 years postoperatively (χ2=47.791, P<0.001). The KT-1000 SSD was decreased from 9.1±3.3 mm to 2.0±1.7 mm (t=11.197, P<0.001). The result of pivot shift test was also improved (10 grade I, 20 grade II, 3 grade III, preoperatively vs 30 grade 0, 3 grade I, postoperatively, U=5.161, P<0.001). The ATS was reduced from 5.7±3.9 mm to 3.5±3.2 mm (t=3.530, P=0.001). However, there was no statistically significant decrease in the ATS of the ATS negative group (t=0.400, P=0.695). The ATS of the ATS positive group was reduced from 8.7±1.8 mm to 5.0±3.3 mm (t=4.765, P<0.001), and the ATS reduction of the ATS positive group was greater than that of the ATS negative group (3.7±3.3 mm vs 0.3±2.8 mm, t=3.115, P=0.004). Conclusion In patients undergoing ACL reconstruction, the transtibial pull-out suture repair for chronic LMPR avulsion yielded meniscus healing rate of 97% with improved subjective knee function and objective knee stability and better restored the tibiofemoral relationship for patients with excessive ATS. Key words: Anterior cruciate ligament reconstruction; Menisci, tibial; Treatment outcome; Arthroscopy
目的评价慢性外侧半月板后根撕脱伤联合前交叉韧带重建术后的临床、放射学和关节镜检查结果。方法回顾性分析2015年7月至2017年6月共33例接受经胫骨拔出缝合修复慢性LMPR撕脱伤并应用腘绳肌移植物重建前交叉韧带的患者。共有30名男性和3名女性,平均年龄27.7±7.5岁(范围17-45岁),平均BMI为25.2±3.7 kg/m2(范围19.4-36.7 kg/m2)。所有患者都可以接受至少两年的随访。再次进行关节镜检查以评估修复半月板的愈合状态。主观膝关节功能通过Lysholm和Tegner评分进行评估。目的应用KT-1000型侧差关节测量仪(SSD)和枢轴移位试验对麻醉状态下膝关节稳定性进行评价。通过轴向MRI测量胫骨前半脱位(ATS)来评估胫股关系。在术前ATS≥6mm(ATS阳性组18例)和<6mm(ATS阴性组15例)的患者之间,还比较了术后ATS和ATS减少的情况。结果经平均27.5±4.0个月(24~39个月)随访,LMPR撕脱伤完全愈合23例(70%),部分愈合9例(27%),复视关节镜检查1例(3%)未愈合。Lysholm评分从术后1年的60.4±13.6增加到82.7±11.1,术后2年的91.4±9.1(F=155.96,P<0.001)。Tegner评分从术前1年的3(2,5)增加到4(3,5),术后两年的6(4,6)(χ2=47.791,P<0.001(术前I级10例,II级20例,III级3例,与术后0级30例,I级3例相比,U=5.161,P<0.001)。ATS从5.7±3.9 mm减少到3.5±3.2 mm(t=3.530,P=0.001)。然而,ATS阴性组的ATS没有统计学意义的减少(t=0.400,P=0.695)。ATS阳性组的ATS从8.7±1.8 mm减少到5.0±3.3 mm(t=4.765,P<001),ATS阳性组的ATS减少量大于ATS阴性组(3.7±3.3 mm vs 0.3±2.8 mm,t=3.115,P=0.004),经胫骨拔出缝线修复慢性LMPR撕脱伤的半月板愈合率为97%,改善了主观膝关节功能和客观膝关节稳定性,并更好地恢复了ATS过度患者的胫股关系。关键词:前交叉韧带重建;半月板,胫骨;治疗结果;关节镜检查
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引用次数: 0
Influence of patella position on soft tissue balance and clinical outcomes in patients undergoing total knee arthroplasty via a midvastus approach 髌骨位置对经股中入路全膝关节置换术患者软组织平衡及临床结果的影响
Q4 Medicine Pub Date : 2020-04-01 DOI: 10.3760/CMA.J.CN121113-20200225-00101
Kaiyuan Liu, Dong Yang, Tianyang Xu, L. Fan, Junjie Jiang, Chi Wang, Hengli Lu
Objective To compare the effects of patellar position on the balance of soft tissue during the operation and the postoperative outcomes in minimally invasive total knee arthroplasty via a midvastus approach. Methods From December 2018 to February 2019, a total of 55 patients were enrolled for primary total knee arthroplasty via a midvastus approach. All patients were randomly divided into 2 groups by random number table. During the operation, the gap balance technique was used with patella reduced or subluxated to complete the osteotomy and balance of soft tissue. The changes of gap and varus-valgus angle were compared between the patellar reduction group and the patellar subluxation group in both extension and flexion position. These data were also compared before and after reducing patellar in the patellar subluxation group. Furthermore, the differences of femoral prosthesis rotation, mechanical femoral axis to tibial axis angle, Knee Society score (KSS), visual analogue scale (VAS) and range of motion (ROM) were compared between the two groups. Results All patients finished 6 months follow-up, including 27 patients in the patellar reduction group and 28 patients in the patellar subluxation group. After osteotomy and soft tissue balance during the operation, there was no significant difference in gap and varus-valgus angle between two groups in either extension or flexion position. While in the patellar subluxation group, the flexion gap was 10.5±0.3 mm with patella subluxated, less than 11.0 ± 0.3 mm after reducing the patella. The varus-valgus angle was 1.5±0.3 with patella subluxated, less than 2.3±0.4 degree after reducing the patella. The difference was statistically significant (t=4.180, P 0.05). The rotation angle of the femoral component in the patellar subluxation group was -0.49°±1.2°, and the external rotation angle was smaller than that in the patellar reduction group (0.24°±1.3°). The difference was statistically significant (t=2.116, P=0.039). At one month after operation, ROM of the patellar reduction group was 109.6°±8.5° which was higher than that of the patellar subluxation group (104.9°±8.6°, t=2.048, P=0.046). There was no significant difference in ROM between the two groups at 3 and 6 months (P>0.05). Moreover, there was no significant difference in KSS and VAS at 1, 3 and 6 months after operation (P>0.05). Conclusion In the minimally invasive total knee arthroplasty, it is suggested to balance the soft tissue as much as possible with the patellar reduced. Otherwise, the consequence of increased flexion space, increased varus and increased internal rotation of femoral prosthesis should be considered. The patients undergoing soft tissue balance with patella reduced have better ROM in the early stage postoperatively. Key words: Arthroplasty, replacement, knee; Patella; Treatment outcome
目的比较微创股中入路全膝关节置换术中髌骨位置对软组织平衡的影响及术后效果。方法从2018年12月至2019年2月,共有55名患者通过股中部入路进行初次全膝关节置换术。采用随机数表将所有患者随机分为2组。术中采用间隙平衡技术,髌骨复位或半脱位,完成软组织截骨和平衡。比较髌骨复位组和髌骨半脱位组在伸屈位间隙和外翻内翻角的变化。还比较了髌骨半脱位组髌骨复位前后的这些数据。此外,还比较了两组股骨假体旋转、股骨轴与胫骨轴的机械角度、膝关节学会评分(KSS)、视觉模拟评分(VAS)和运动范围(ROM)的差异。结果所有患者均完成了6个月的随访,其中髌骨复位组27例,髌骨半脱位组28例。在截骨和手术过程中的软组织平衡后,两组在伸展或屈曲位置的间隙和外翻内翻角度没有显著差异。髌骨半脱位组髌骨半脱位时屈曲间隙为10.5±0.3mm,髌骨复位后屈曲间隙小于11.0±0.3mm。髌骨半脱位时外翻角度为1.5±0.3°,髌骨复位后外翻角度小于2.3±0.4°。差异有统计学意义(t=4.180,P 0.05)。髌骨半脱位组股骨组件旋转角度为-0.49°±1.2°,外旋角度小于髌骨复位组(0.24°±1.3°)。差异有统计学价值(t=2.116,P=0.039)。术后1个月,髌骨复位组ROM为109.6°±8.5°,高于髌骨半脱位组(104.9°±8.6°,t=2.048,P=0.046),3个月和6个月时两组ROM差异无统计学意义(P>0.05),结论在微创全膝关节置换术中,应尽量平衡软组织,减少髌骨损伤。否则,应考虑股骨假体屈曲间隙增加、内翻增加和内旋增加的后果。髌骨复位的软组织平衡患者术后早期ROM较好。关键词:关节成形术,置换术,膝关节;Patella;治疗结果
{"title":"Influence of patella position on soft tissue balance and clinical outcomes in patients undergoing total knee arthroplasty via a midvastus approach","authors":"Kaiyuan Liu, Dong Yang, Tianyang Xu, L. Fan, Junjie Jiang, Chi Wang, Hengli Lu","doi":"10.3760/CMA.J.CN121113-20200225-00101","DOIUrl":"https://doi.org/10.3760/CMA.J.CN121113-20200225-00101","url":null,"abstract":"Objective \u0000To compare the effects of patellar position on the balance of soft tissue during the operation and the postoperative outcomes in minimally invasive total knee arthroplasty via a midvastus approach. \u0000 \u0000 \u0000Methods \u0000From December 2018 to February 2019, a total of 55 patients were enrolled for primary total knee arthroplasty via a midvastus approach. All patients were randomly divided into 2 groups by random number table. During the operation, the gap balance technique was used with patella reduced or subluxated to complete the osteotomy and balance of soft tissue. The changes of gap and varus-valgus angle were compared between the patellar reduction group and the patellar subluxation group in both extension and flexion position. These data were also compared before and after reducing patellar in the patellar subluxation group. Furthermore, the differences of femoral prosthesis rotation, mechanical femoral axis to tibial axis angle, Knee Society score (KSS), visual analogue scale (VAS) and range of motion (ROM) were compared between the two groups. \u0000 \u0000 \u0000Results \u0000All patients finished 6 months follow-up, including 27 patients in the patellar reduction group and 28 patients in the patellar subluxation group. After osteotomy and soft tissue balance during the operation, there was no significant difference in gap and varus-valgus angle between two groups in either extension or flexion position. While in the patellar subluxation group, the flexion gap was 10.5±0.3 mm with patella subluxated, less than 11.0 ± 0.3 mm after reducing the patella. The varus-valgus angle was 1.5±0.3 with patella subluxated, less than 2.3±0.4 degree after reducing the patella. The difference was statistically significant (t=4.180, P 0.05). The rotation angle of the femoral component in the patellar subluxation group was -0.49°±1.2°, and the external rotation angle was smaller than that in the patellar reduction group (0.24°±1.3°). The difference was statistically significant (t=2.116, P=0.039). At one month after operation, ROM of the patellar reduction group was 109.6°±8.5° which was higher than that of the patellar subluxation group (104.9°±8.6°, t=2.048, P=0.046). There was no significant difference in ROM between the two groups at 3 and 6 months (P>0.05). Moreover, there was no significant difference in KSS and VAS at 1, 3 and 6 months after operation (P>0.05). \u0000 \u0000 \u0000Conclusion \u0000In the minimally invasive total knee arthroplasty, it is suggested to balance the soft tissue as much as possible with the patellar reduced. Otherwise, the consequence of increased flexion space, increased varus and increased internal rotation of femoral prosthesis should be considered. The patients undergoing soft tissue balance with patella reduced have better ROM in the early stage postoperatively. \u0000 \u0000 \u0000Key words: \u0000Arthroplasty, replacement, knee; Patella; Treatment outcome","PeriodicalId":36405,"journal":{"name":"中华骨科杂志","volume":"40 1","pages":"433-440"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42997664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assisting technical development in closed reduction for distal femoral fractures 协助股骨远端骨折闭合复位技术的发展
Q4 Medicine Pub Date : 2020-04-01 DOI: 10.3760/CMA.J.CN121113-20190322-00117
N. Zhou
Distal femoral fracture is one of the difficult fractures to treat due to the complex types and varies complications after operation. The concept about closed reduction to deal with fracture has been accepted widely with the innovation of surgical technology and internal fixation. Some tissue, including joint capsule, ligaments, muscles and tendons, surround femoral condyle, which indicates they may tract the fractured bone to deformity. In addition, the difficulty of reduction during operation may be increased with combined other injuries. At present, the idea of using different methods to reduce the re-injury before the closed reduction of distal femoral fracture has been recognized and popularized. A kind of appropriate reduction and internal fixation can not only reduce the difficulty of operation but also shorten the operation duration and reduce the incidence of postoperative complications. In addition to the common reduction method of manual reduction, plate can not only be taken as internal fixation, but also achieve reduction reviewing literatures about the methods of reduction in recent years. However, it is not suitable for some complex fractures. The traction table is not widely used at present due to varies complications. Distractors like AO distractor or other kinds of femoral distractors can achieve reduction by providing reverse force. However, it should be noticed that some risk factors such as vascular and nerve injury can occur during the surgery. The present study summarized different ways that were adopted during the closed reduction and internal fixation of distal femoral fractures. The appropriate method chose by surgeons to improve the efficiency and reduce risks should be used based on the need of surgery.
股骨远端骨折类型复杂,术后并发症多样,是治疗难度较大的骨折之一。随着手术技术和内固定技术的不断创新,闭合复位治疗骨折的理念已被广泛接受。股骨髁周围有一些组织,包括关节囊、韧带、肌肉和肌腱,这表明它们可能将骨折的骨头牵引到畸形。此外,合并其他损伤可能会增加术中复位的难度。目前,在股骨远端骨折闭合复位前采用不同方法减少再损伤的思路已经得到了认可和推广。一种适当的复位内固定不仅可以降低手术难度,而且可以缩短手术时间,减少术后并发症的发生。除了常见的人工复位方法外,钢板不仅可以作为内固定,还可以实现复位,回顾近年来关于复位方法的文献。但是,对于一些复杂的骨折并不适用。由于各种并发症,目前牵引台尚未广泛应用。像AO牵张器或其他种类的股骨牵张器可以通过提供反向力实现复位。但需要注意的是,手术过程中可能出现血管、神经损伤等危险因素。本研究总结了股骨远端骨折闭合复位内固定采用的不同方法。外科医生应根据手术需要选择合适的方法,以提高手术效率,降低手术风险。
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引用次数: 0
Effects of bone-resorptive lesion on stress distribution of the femoral head and on progression in patients with osteonecrosis of the femoral head 骨吸收损伤对股骨头应力分布及股骨头坏死进展的影响
Q4 Medicine Pub Date : 2020-04-01 DOI: 10.3760/CMA.J.CN121113-20200227-00106
Guang-Bo Liu, Y. Mei, Hai-yang Ma, Qiang Lu, H. Meng, Qi Quan, Yuxuan Zhang, Jun Zhao, H. J. Li, Ai-yuan Wang, Hai Xin, Duanduan Chen, Shibi Lu, Jiang Peng
Objective To investigate effects of bone-resorptive lesion on stress distribution of femoral head and on progression in patients with osteonecrosis of the femoral head (ONFH). Methods From April 2014 to September 2018, a total of 155 femoral heads from 94 patients diagnosed with ARCO stage II and III ONFH were retrospectively reviewed, including 77 males and 17 females with aged 39.90±10.45 years old (ranged from 18-64 years). The hips were divided into two groups according to whether there were bone-resorptive lesions. Further, we compared whether there was statistical difference between the two groups in staging. Then, a case of ARCO II hip joint without bone-resorptive lesion was selected from the included patients. Six femoral head with different diameters of spherical bone-resorptive lesion of 5 mm, 7 mm, 10 mm, 14 mm, 18 mm, and 23 mm were simulated. The influence of bone-resorptive lesion on the stress distribution of necrotic area and a spherical shell extending 1 mm radially around the bone-resorptive lesion was investigated by finite element method in slow walking conditions. Results Of the 155 ONFH hips, 67 hips are complicated by bone-resorptive lesions, of which 17 were ARCO II, 50 were ARCO III. A total of 88 hips did not contain bone-resorptive lesions, of which 58 were ARCO II, ARCO III 30 cases. The proportion of ARCO stage II in the group with bone-resorptive lesions was significantly higher than that in the group without bone-resorptive lesions (χ2=25.03, P=0.000). The finite element stress distribution cloud diagram showed that there was a stress concentration area around the bone-resorptive lesions. The maximum von Mises stress around bone-resorptive lesions in the models that contained a synthetic bone-resorptive lesions were significantly higher than those reported in the matched, non-synthetic bone-resorptive lesions finite element models (t=3.139, P=0.026). The values for maximum von Mises stress around bone-resorptive lesions were 6.94±1.78 MPa and 5.01±0.35 MPa for the group with synthetic bone-resorptive lesions and the group non-synthetic bone-resorptive lesions, respectively. There was a positive correlation between the diameter of bone-resorptive lesions and the maximum and mean von Mises stress of necrotic areas as well as the maximum von Mises stress around bone-resorptive lesions. Conclusion Bone-resorptive lesions can increase the maximum stress and average stress in the necrotic area. The larger the bone-resorptive lesion, the more the stress increases. There is a stress concentration area around the bone-resorptive lesions, which may accelerate the collapse of the femoral head. Key words: Femur head necrosis; Bone resorption; Finite element analysis
目的探讨骨吸收损伤对股骨头坏死(ONFH)患者股骨头应力分布及进展的影响。方法回顾性分析2014年4月至2018年9月诊断为ARCO II期和III期ONFH的94例患者共155个股骨头,其中男性77例,女性17例,年龄39.90±10.45岁(18-64岁)。根据髋部有无骨吸收病变分为两组。进一步,我们比较两组在分期上是否有统计学差异。然后,从纳入的患者中选择一例无骨吸收病变的ARCO II型髋关节。模拟5、7、10、14、18、23 mm不同直径的球状骨吸收病变股骨头。采用有限元法研究了慢速行走条件下骨吸收损伤对坏死区域应力分布的影响,并研究了骨吸收损伤周围径向延伸1 mm的球壳。结果155例ONFH髋关节中合并骨吸收病变67例,其中ARCOⅱ型17例,ARCOⅲ型50例。无骨吸收病变88例,其中ARCOⅱ型58例,ARCOⅲ型30例。有骨吸收病变组ARCO II期比例显著高于无骨吸收病变组(χ2=25.03, P=0.000)。有限元应力分布云图显示,骨吸收病灶周围存在应力集中区。包含合成骨吸收病变的模型中骨吸收病变周围的最大von Mises应力显著高于匹配的非合成骨吸收病变有限元模型(t=3.139, P=0.026)。合成骨吸收病变组和非合成骨吸收病变组骨吸收周围最大von Mises应力值分别为6.94±1.78 MPa和5.01±0.35 MPa。坏死区von Mises应力最大值和平均值以及骨吸收病灶周围von Mises应力最大值与骨吸收病灶直径呈正相关。结论骨吸收性病变可增加坏死区最大应力和平均应力。骨吸收损伤越大,应力越大。骨吸收病变周围存在应力集中区,可能加速股骨头塌陷。关键词:股骨头坏死;骨吸收;有限元分析
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引用次数: 2
The effect of gammairradiation for collagen in demineralized bone matrix particles with differences size γ辐照对不同大小脱矿骨基质颗粒中胶原蛋白的影响
Q4 Medicine Pub Date : 2020-03-16 DOI: 10.3760/CMA.J.CN121113-20200221-00086
Jiang-tao Feng, Xiong-Gang Yang, Feng Wang, Kun-Chi Hua, D. Lun
Objective To investigate the effects of different particle sizes on the collagen structure of demineralized bone matrix (DBM) and the effectiveness of dry ice as an irradiation protectant in the procedure of gamma irradiation. Methods DBM samples with different particle sizes (0.5-1.0 mm, 1.2-2.8 mm, 3.3-4.7 mm and 5.7-7.0 mm) were prepared, and sterilized with several doses of gamma irradiation (0 kGy, 15 kGy and 25 kGy) at room temperature. Additionally, another group of DBM samples were sterilized with 25 kGy gamma irradiation with protective agent. Changes in surface and characteristics of collagen were observed by using scanning electron microscope (SEM), Sodium dodecyl sulfatepolyacrylamide gel electrophoresis (SDS-PAGE), differential scanning calorimetry (DSC) and carbonyl content. Results The color of collagen extract indicated that oxidative damage is directly related to irradiation dose. SEM showed that the gamma irradiation caused collagen structure disorder and fiber breakage. As the irradiation doses increased, the damage area significantly increased. When the particle size increased, the damage area tended to decrease. The DSC showed that the thermal denaturation temperature of 5.7-7 mm, 3.3-4.7 mm, 1.2-2.8 mm and 0.5-1.0 mm were 142.8℃, 97.3℃,84.3℃ and 83.9℃, respectively. The differences of the thermal denaturation temperatures among the four particle sizes were statistically significant (F=0.560, P=0.650). Collagen structure was destroyed by gamma irradiation, resulting in a decrease in collagen molecular weight. While, large particle DBM had a tendency to resist radiation damage. There was a significant difference on the contents of carbonyl in collagen from same particle sizes of DBM with different irradiation dose. The carbonyl content gradually decreased with the increase of particle size, but the difference was not statistically significant (F=0.560, P=0.650). Conclusion The gamma irradiation and collagen oxidative damage have obvious dose-response relationship. With the increase of gamma irradiation dose, the degree of collagen damage increases. The sizes of DBM could affect the sensitivity of collagen to gamma irradiation. With the decrease of particle sizes, DBM particles are more susceptible to gamma irradiation damage. Additionally, dry ice, as a radiation protection agent, has a certain degree protection effect against radiation. Key words: Bone matrix; Collagen; Radiation; Gamma rays
目的研究不同粒径对脱矿骨基质(DBM)胶原结构的影响,以及干冰在γ射线照射过程中作为辐照保护剂的有效性。方法制备不同粒径(0.5~1.0mm、1.2~2.8mm、3.3~4.7mm和5.7~7.0mm)的DBM样品,并在室温下用不同剂量的γ射线(0kGy、15kGy和25kGy)灭菌。此外,另一组DBM样品用25kGyγ射线和保护剂灭菌。用扫描电子显微镜(SEM)、十二烷基硫酸钠-聚丙烯酰胺凝胶电泳(SDS-PAGE)、差示扫描量热法(DSC)和羰基含量观察了胶原表面和特性的变化。结果胶原提取物的颜色表明氧化损伤与辐照剂量直接相关。扫描电镜显示,γ射线辐照引起胶原结构紊乱和纤维断裂。随着辐照剂量的增加,损伤面积显著增加。当颗粒尺寸增大时,损伤面积趋于减小。DSC表明,5.7-7mm、3.3-4.7mm、1.2-2.8mm和0.5-1.0mm的热变性温度分别为142.8℃、97.3℃、84.3℃和83.9℃。四种粒度的热变性温度差异具有统计学意义(F=0.560,P=0.650)。γ射线破坏了胶原结构,导致胶原分子量下降。而大颗粒DBM具有抗辐射损伤的倾向。相同粒径的DBM在不同辐照剂量下,胶原中羰基含量存在显著差异。羰基含量随着粒径的增加而逐渐降低,但差异无统计学意义(F=0.560,P=0.650)。结论γ射线与胶原氧化损伤具有明显的量效关系。随着γ辐照剂量的增加,胶原损伤程度增加。DBM的大小可能影响胶原对γ射线的敏感性。随着颗粒尺寸的减小,DBM颗粒更容易受到伽马辐射损伤。此外,干冰作为一种辐射防护剂,对辐射有一定的防护作用。关键词:骨基质;胶原蛋白;辐射;伽马射线
{"title":"The effect of gammairradiation for collagen in demineralized bone matrix particles with differences size","authors":"Jiang-tao Feng, Xiong-Gang Yang, Feng Wang, Kun-Chi Hua, D. Lun","doi":"10.3760/CMA.J.CN121113-20200221-00086","DOIUrl":"https://doi.org/10.3760/CMA.J.CN121113-20200221-00086","url":null,"abstract":"Objective \u0000To investigate the effects of different particle sizes on the collagen structure of demineralized bone matrix (DBM) and the effectiveness of dry ice as an irradiation protectant in the procedure of gamma irradiation. \u0000 \u0000 \u0000Methods \u0000DBM samples with different particle sizes (0.5-1.0 mm, 1.2-2.8 mm, 3.3-4.7 mm and 5.7-7.0 mm) were prepared, and sterilized with several doses of gamma irradiation (0 kGy, 15 kGy and 25 kGy) at room temperature. Additionally, another group of DBM samples were sterilized with 25 kGy gamma irradiation with protective agent. Changes in surface and characteristics of collagen were observed by using scanning electron microscope (SEM), Sodium dodecyl sulfatepolyacrylamide gel electrophoresis (SDS-PAGE), differential scanning calorimetry (DSC) and carbonyl content. \u0000 \u0000 \u0000Results \u0000The color of collagen extract indicated that oxidative damage is directly related to irradiation dose. SEM showed that the gamma irradiation caused collagen structure disorder and fiber breakage. As the irradiation doses increased, the damage area significantly increased. When the particle size increased, the damage area tended to decrease. The DSC showed that the thermal denaturation temperature of 5.7-7 mm, 3.3-4.7 mm, 1.2-2.8 mm and 0.5-1.0 mm were 142.8℃, 97.3℃,84.3℃ and 83.9℃, respectively. The differences of the thermal denaturation temperatures among the four particle sizes were statistically significant (F=0.560, P=0.650). Collagen structure was destroyed by gamma irradiation, resulting in a decrease in collagen molecular weight. While, large particle DBM had a tendency to resist radiation damage. There was a significant difference on the contents of carbonyl in collagen from same particle sizes of DBM with different irradiation dose. The carbonyl content gradually decreased with the increase of particle size, but the difference was not statistically significant (F=0.560, P=0.650). \u0000 \u0000 \u0000Conclusion \u0000The gamma irradiation and collagen oxidative damage have obvious dose-response relationship. With the increase of gamma irradiation dose, the degree of collagen damage increases. The sizes of DBM could affect the sensitivity of collagen to gamma irradiation. With the decrease of particle sizes, DBM particles are more susceptible to gamma irradiation damage. Additionally, dry ice, as a radiation protection agent, has a certain degree protection effect against radiation. \u0000 \u0000 \u0000Key words: \u0000Bone matrix; Collagen; Radiation; Gamma rays","PeriodicalId":36405,"journal":{"name":"中华骨科杂志","volume":"40 1","pages":"353-361"},"PeriodicalIF":0.0,"publicationDate":"2020-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44538349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of icariin on adhesion and cytoskeleton of osteoblasts in response to the extreme mechanical environment of hypergravity icariin对超重力极端力学环境下成骨细胞粘附和细胞骨架的影响
Q4 Medicine Pub Date : 2020-03-16 DOI: 10.3760/CMA.J.CN121113-20200220-00082
Li-cheng Song, Hua-feng Zhang, W. Cheng, Ya Li, Dong Li, Ya-fei Qin, Xin Wan, Ruixin Li, Hui Li, Xi-zheng Zhang
Objective To establish a hypergravity loading model with a high-acceleration centrifugal loading device and to investigate the effects of different hypergravity loading and icariin on osteoblast adhesion and cytoskeleton. Methods MC3T3-E1 cells were seeded in the dishes of cell culture at a density of 2×105/cm2. And the experiment was divided into 6 groups: control group (without icariin and loading); simple administration group (only icariin); 10 G loading group (only loading); 10 G administration group (with icariin and loading); 40 G loading group (only loading); 40 G administration group (with icariin and loading). The experimental loading group was loaded with MC3T3-E1 cells using a high-acceleration centrifugal loader. And continuous loading for 3 d, 30 min per d. The control group and the simple administration group were exposed to normal gravity, and the remaining conditions were not different from the experimental group. Icariin was used at a concentration of 10-7 mol/L in all administration groups, and the experiments were carried out according to the method of preventive administration. At the same time, the related molecular biological techniques such as alizarin red staining, alkaline phosphatase (ALP) activity measurement, CCK-8 cell proliferation experiment, cytoskeleton phalloidin staining, qPCR and Western Blot were used to detect the effects of icariin on osteoblasts adhesion protein integrin α5 and integrin β1 and cytoskeleton protein F-actin under hypergravity extreme mechanical environment. Results All models were successfully prepared. The alizarin red staining: The icariin could significantly promote the formation of osteoblastic calcified nodules. And the 10 G loading could also promote the mineralization of osteoblasts and increase the number of mineralized nodules, while the mineralization and the number of mineralized nodules of osteoblasts are significantly reduced in 40 G loading. ALP activity test: The OD values of simple administration group, 10 G loading group and 40 G loading group were 0.246, 0.331 and 0.163, respectively. Compared with 0.207 in the control group, the differences were statistically significant (P<0.05). The 10 G administration group and the 40 G administration group were 0.373 and 0.180, and the differences were statistically significant (P<0.05). The results of CCK-8 proliferation experiments: The OD value of simple administration group were 0.650, which was statistically significant compared with 0.551 of control group (P=0.031). The 10 G loading group and 40 G loading group were 1.193 and 0.245, and their differences with the control group were both statistically significant (P<0.05). The OD value of 10G administration group and the 40 G administration group were 1.300 and 0.310, which were significantly different from the respective loading groups (P<0.05). Phalloidin staining: 10 G loading significantly increased the number of cells, but the changes in cells morphology and skele
目的用高加速度离心加载装置建立超重力加载模型,研究不同超重力加载和icariin对成骨细胞粘附和细胞骨架的影响。方法将MC3T3-E1细胞以2×。实验分为6组:对照组(不加icariin和负荷);单纯给药组(仅icariin);10G加载组(仅加载);10g给药组(加icariin和负荷);40G加载组(仅加载);40G给药组(加icariin和负荷)。实验装载组使用高加速度离心装载机装载MC3T3-E1细胞。连续负荷3d,每天30min。对照组和单纯给药组暴露于正常重力下,其余条件与实验组无差异。在所有给药组中均以10-7mol/L的浓度使用Icariin,并根据预防性给药方法进行实验。同时,相关的分子生物学技术如茜素红染色、碱性磷酸酶(ALP)活性测定、CCK-8细胞增殖实验、细胞骨架鬼笔素染色、,采用qPCR和Western Blot检测icariin在超重力极端机械环境下对成骨细胞粘附蛋白整合素α5和整合素β1以及细胞骨架蛋白F-肌动蛋白的影响。结果所有模型均成功制备。茜素红染色:icariin能明显促进成骨细胞钙化结节的形成。10G负荷也能促进成骨细胞矿化,增加矿化结节的数量,而40G负荷能显著降低成骨细胞的矿化和矿化结节的数目。ALP活性测试:单纯给药组、10g负荷组和40G负荷组的OD值分别为0.246、0.331和0.163。与对照组的0.207相比,差异有统计学意义(P<0.05)。10g给药组和40G给药组的OD值分别为0.373和0.180,差异有显著性(P<0.05);CCK-8增殖实验结果:单纯给药组OD值为0.650,10G给药组和40G给药组的OD值分别为1.300和0.310,Phalloidin染色:10G负载显著增加细胞数量,但细胞形态和骨架变化不明显。40G负荷显著抑制了细胞数量的增加,同时使细胞的伪足变短甚至消失。40G的负载使细胞骨架受到严重损伤,甚至导致细胞死亡。Icariin对细胞形态无影响,但对细胞负载后有一定的修复作用。qPCR和Western Blot实验结果均证实icariin处理后整合素α5、整合素β1和F-肌动蛋白的表达上调。10G负载可促进整合素α5、整合素β1和F-肌动蛋白的表达,40G负载可显著抑制mRNA和蛋白质的表达。结论10g和icariin均能促进成骨细胞的发育、细胞粘附和细胞骨架的稳定,40G对成骨细胞有明显的抑制作用。关键词:成骨细胞;超重力;细胞粘附;细胞骨架
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引用次数: 0
Advance in the study of distal junctional problem after thoracolumbar surgery 胸腰椎手术后远端关节问题的研究进展
Q4 Medicine Pub Date : 2020-03-16 DOI: 10.3760/CMA.J.CN121113-20190625-00279
Lei Yuan, Xinling Zhang, Yan Zeng, Xiaoxi Yang, Zhongqiang Chen
Distal junctional problem (DJP) is one of the severe complications after spinal correction, fixation and fusion. As the number of patients receiving spinal surgery increased recently, the incidence of DJP also increased dramatically. Compared with proximal junctional problem, the incidence of DJP is low. However, the clinical symptoms are severe, and the rate of surgical revision is high in patients with distal junctional problems. DJP include distal junctional kyphosis (DJK) and distal junctional failure(DJF). The definition of DJK is confusing, however, and the most commonly used was that the distal junction Angle at the last follow-up was greater than 10° and increased by 10° compared with that before surgery. There are 6 DJF modes: progressive loss of lumbar lordosis,acute wedging in the disc below the instrumentation, fracture of LIV, osteoporotic fracture below the long rigid fixation, failure of the instrumentation at LIV, spinal stenosis and or segmental instability underneath the instrumentation. Possible risk factors for DJP include weight, age, type of spinal deformity, osteoporosis, choice of LIV, hip disease, deformity location, surgical approach, surgical procedure, fusion segments, fixation devices, LIV at L5, fixed to S1 with no iliac screws, poor restoration of spinal alignment, et al. Currently, there are some controversies in DJP, mainly including the incidence, risk factors whether needs to and how to revise. The review intends to conduct a simple literature review of the current DJP diagnostic criteria, incidence, risk factors, and other research progress, in order to improve the understanding of the distal junction problem.
远端关节问题(DJP)是脊柱矫正、固定和融合后的严重并发症之一。近年来,随着脊柱手术患者数量的增加,DJP的发病率也急剧上升。与近端交界问题相比,DJP的发生率较低。然而,临床症状严重,手术翻修率高的患者远端结膜问题。DJP包括远端结膜后凸(DJK)和远端结膜衰竭(DJF)。DJK的定义比较混乱,最常用的是最后一次随访时远端结角大于10°,比术前增加10°。DJF有6种模式:腰椎前凸渐进式丧失、内固定物下方的椎间盘急性楔入、LIV骨折、长刚性固定物下方的骨质疏松性骨折、LIV内固定物失效、内固定物下方的椎管狭窄和/或节段性不稳定。DJP可能的危险因素包括体重、年龄、脊柱畸形类型、骨质疏松、LIV的选择、髋关节疾病、畸形位置、手术入路、手术方式、融合节段、固定装置、LIV位于L5、无髂螺钉固定至S1、脊柱对齐恢复不良等。目前,DJP存在一些争议,主要包括发病率、危险因素是否需要以及如何修改。本文拟对目前DJP的诊断标准、发病率、危险因素等研究进展进行简单的文献综述,以提高对远端交界问题的认识。
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引用次数: 0
Experimental research on the trochlear dysplasia with bony and soft tissue model of patellar dislocation 滑车发育不良伴骨软组织模型髌骨脱位的实验研究
Q4 Medicine Pub Date : 2020-03-16 DOI: 10.3760/CMA.J.CN121113-20200220-00084
Hui-jun Kang, Yike Dai, S. Li, Jiangfeng Lu, Faquan Li, G. Ji, Y. Niu
Objective To establish a model of patellar dislocation by femoral osteotomy or surgical release of medial retinaculum in immature rabbits, and observe morphological and trabecular microarchitectural changes in the trochlea. Methods Forty rabbits at 3 months of age were included. All right knees underwent surgery, 20 knees were treated with femoral osteotomy and internal rotation of distal femur to increase femoral anteversion angle (Osteotomy group, OS group), and another 20 knees were treated with surgical release of medial retinaculum and overlap suture of lateral retinaculum (Soft tissue group, ST group). All left knees were acting as internal controls. Micro-CT scans for distal femur were acquired after 4 months post surgery. the height of Medial, central, and lateral trochlear, sulcus angle, and lateral and medial trochlear slope were measured to describe the trochlear morphology, and bone volume fraction (BV/TV), trabecular thickness (Tb.Th), trabecular number (Tb.N), trabecular spacing (Tb.Sp), and bone mineral density (BMD) were calculated to evaluate the microarchitectural structure. All parameters were compared between groups. Results In OS group, one rabbit sustained a hip dislocation without patellar dislocation. Three knees developed complete patellar dislocation in daily flexion position, and the remaining 16 patellae were dislocated when the knee was placed in the maximal extension position. In ST group, 15 knees were complete patellar dislocation in daily flexion position, and 5 knees were without dislocation. A local boss was formed proximal to the entrance of the groove and the articular cartilage was smooth, and no obvious osteoarthritis was observed in OS group. In ST group no boss was formed, while obvious cartilage degeneration and defect was seen. Compared to the control group, the central trochlear height and sulcus angle were greater in both groups, but without significant difference between the two groups. The Tb.Th was increased in both medial and lateral condyle, and Tb.N was decreased in medial condyle compared with its control knees in OS group. The BV/TV, Tb.Th, Tb.N and BMD were decreased and Tb.Sp was increased in both medial and lateral condyle compared with its control knees in ST group. Compared to the OS group, the BV/TV, Tb.Th, Tb.N and BMD were smaller and Tb.Sp was greater in both medial and lateral condyle in ST group, with significant differences. Conclusion The model of patellar dislocation could be successfully achieved by femoral rotational osteotomy to increase femoral anteversion or surgical release of medial retinaculum and overlap suture of lateral retinaculum, and subsequent morphological and trabecular microarchitectural changes in the trochlea are different. Different bony and soft tissue factors should be addressed for different patients with patellar dislocation in clinical practice. Key words: Patellar dislocation; Femur; Patellar ligament; Osteotomy
目的通过股骨截骨或内侧支持带松解术建立未成熟兔髌骨脱位模型,观察滑车的形态学和小梁微结构变化。方法选取3个月龄家兔40只。所有右膝均接受手术,20膝接受股骨截骨和股骨远端内旋以增加股骨前倾角的治疗(截骨组,OS组),另有20膝接受内侧支持带手术松解和外侧支持带重叠缝合的治疗(软组织组,ST组)。所有的左膝都起到了内部控制的作用。术后4个月进行股骨远端的显微CT扫描。测量滑车内侧、中央和外侧的高度、沟角以及滑车外侧和内侧的斜率来描述滑车形态,并计算骨体积分数(BV/TV)、小梁厚度(Tb.Th)、小梁数(Tb.N)、小骨间距(Tb.Sp)和骨密度(BMD)来评估微结构。各组间比较所有参数。结果OS组1只兔髋关节脱位,无髌骨脱位。三个膝关节在日常屈曲位置出现完全髌骨脱位,其余16个髌骨在膝关节处于最大伸展位置时发生脱位。ST组每日屈曲位髌骨完全脱位15膝,无脱位5膝。OS组在凹槽入口附近形成局部凸台,关节软骨光滑,未观察到明显的骨关节炎。ST组未形成凸台,可见明显的软骨变性和缺损。与对照组相比,两组滑车中央高度和沟角均较大,但两组之间无显著差异。OS组内侧髁突和外侧髁突Tb.Th均升高,内侧髁突Tb.N较对照组下降。ST组内侧髁和外侧髁的BV/TV、Tb.Th、Tb.N和BMD均较对照膝下降,Tb.Sp升高。与OS组相比,ST组内侧髁突和外侧髁突的BV/TV、Tb.Th、Tb.N和BMD均较小,Tb.Sp较大,差异有统计学意义。结论股骨旋转截骨增加股骨前倾角或手术释放内侧支持带和外侧支持带重叠缝合可成功建立髌骨脱位模型,但随后滑车的形态学和小梁微结构变化不同。在临床实践中,不同的髌骨脱位患者应考虑不同的骨和软组织因素。关键词:髌骨脱位;股骨;髌韧带;截骨术
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中华骨科杂志
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