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Single bundle anatomic intrathecal reconstruction of proximal injury of anterior cruciate ligament with dissociate peroneus longus tendon and semitendinosus tendon 腓长肌腱和半腱肌腱游离的前交叉韧带近端损伤单束鞘内解剖重建
Q4 Medicine Pub Date : 2020-01-16 DOI: 10.3760/CMA.J.ISSN.0253-2352.2020.02.002
Cailong Liu, Lichuang Wu, Yi-lin Ye
Objective To explore the feasibility and clinical effect of single bundle anatomic intrathecal reconstruction of proximal injury of anterior cruciate ligament (ACL) using dissociate peroneus longus tendon combined with semitendinosus tendon. Methods From January 2015 to September 2016, a total of 24 patients with proximal injury of ACL, confirmed by arthroscopy, were admitted to the sports medicine department of our hospital. The ACL was completely ruptured from the proximal footprint and the tibial side residual remained intact. There were 19 males and 5 females; 16 cases on the right side and 8 cases on the left side. The mean age was 27.88±7.13 years old; The interval between injury and surgery was 14.83±9.09 d; The dissociate peroneus longus tendon and semitendinosus tendonfrom the injured extremity were folded in half, then braided and trimmed into ACL graft for use. The ACL remnant was preserved and the graft was pulled through the stump for single bundle anatomic intrathecal reconstruction. The ACL graft was fixed with Endobutton on the femoral side and interference screw on the tibial side. The results of Lachman test, Lysholm scores, Tegner scores and International Knee Documentation Committee (IKDC) subjective scores of knee before operation and at final visit were recorded to evaluate the stability and function of the knee. Visual analogue score (VAS) was used to record the changes of pain at the site where the peroneal longus tendon was harvested. The American Orthopaedic Foot and Ankle Society (AOFAS) Ankle-Hindfoot Scores were recorded before injury and at the final visit to assess the effect of ankle function after peroneal longus tendon resection. Results The diameter of the ACL graft made of dissociate peroneus longus tendon and semitendinosus tendon is 8.88±0.30 mm. All patients were followed up at the outpatient clinic, with an average of 34.38±5.40 months, and no serious complications such as rerupture and joint infection were found. There were 16 grade B, 6 grade C and 2 grade D for preoperative Lachman test, none with hard end point. At last vist, there were 23 cases of grade A and 1 grade B, all with hard end points for Lachman test. At the preoperative and final visit, the Lysholm scores of the knee joint were 35.20±11.92 and 94.29±2.92 (t=23.850, P=0.000). Tegner scores were 3.46±0.93 and 8.04±1.00 (t=16.653, P=0.000). The subjective IKDC scores of knee joint were 47.63±13.06 and 91.71±3.75 (t=15.972, P=0.000). At the final visit, all the indicators of the knee were improved compared with those before surgery, and the difference was statistically significant.The AOFAS scores before injury and at the final visit were 98.83 (2.78) and 98.17 (4.01), respectively, with no statistically significant difference (t=1.850, P=0.076) . The VAS scores for the harvest of theperoneus longus tendon were 4.50±1.41, 0.54±0.65 and 0.29±0.55 immediately and 6 months after the operation and at the last visit.There was statistica
目的探讨游离腓骨长肌腱联合半腱肌肌腱单束解剖鞘内重建前交叉韧带近端损伤的可行性及临床效果。方法2015年1月至2016年9月,我院运动医学部收治经关节镜检查确诊的前交叉韧带近端损伤患者24例。前交叉韧带从近端足部完全断裂,胫骨侧残余完好无损。男性19只,女性5只;右侧16例,左侧8例。平均年龄27.88±7.13岁;损伤至手术时间为14.83±9.09 d;将受伤肢体游离的腓骨长肌腱和半腱肌腱对折,编织并修剪成ACL移植物使用。保留前交叉韧带残肢,将移植物穿过残肢进行单束解剖鞘内重建。前交叉韧带移植物用Endobutton在股侧固定,干涉螺钉在胫侧固定。记录术前及终诊时膝关节的Lachman试验、Lysholm评分、Tegner评分及国际膝关节文献委员会(International Knee Documentation Committee, IKDC)主观评分,评价膝关节的稳定性和功能。采用视觉模拟评分法(Visual analogue score, VAS)记录腓骨长肌腱切除部位的疼痛变化。美国骨科足踝学会(AOFAS)踝关节-后足评分在损伤前和最后一次访问时记录,以评估腓长肌腱切除术后踝关节功能的影响。结果游离腓骨长肌腱和半腱肌腱制成的前交叉韧带移植物直径为8.88±0.30 mm。所有患者均在门诊随访,平均34.38±5.40个月,无复发、关节感染等严重并发症。术前Lachman试验B级16例,C级6例,D级2例,无硬终点。最后访视A级23例,B级1例,均为Lachman测试硬终点。术前和终诊时膝关节Lysholm评分分别为35.20±11.92和94.29±2.92 (t=23.850, P=0.000)。Tegner评分分别为3.46±0.93和8.04±1.00 (t=16.653, P=0.000)。膝关节主观IKDC评分分别为47.63±13.06分和91.71±3.75分(t=15.972, P=0.000)。终诊时膝关节各项指标均较术前改善,差异有统计学意义。伤前和末访时AOFAS评分分别为98.83(2.78)分和98.17(4.01)分,差异无统计学意义(t=1.850, P=0.076)。术后即刻、术后6个月及末次访视腓骨长肌腱的VAS评分分别为4.50±1.41、0.54±0.65、0.29±0.55。术后6个月与即刻评分比较,差异有统计学意义(t=14.900, P=0.001)。术后6个月评分与末次访视比较,差异有统计学意义(t=2.770, P=0.011)。结论游离腓骨长肌腱和半腱肌腱单束解剖鞘内重建前交叉韧带近端损伤是可行的,临床效果良好。关键词:前交叉韧带重建;解剖;关节内窥镜
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引用次数: 0
The influence of spinal sagittal balance on acetabular component orientation and its clinical relevance 脊柱矢状面平衡对髋臼成分取向的影响及其临床意义
Q4 Medicine Pub Date : 2020-01-16 DOI: 10.3760/CMA.J.ISSN.0253-2352.2020.02.006
Kangming Chen, Gang-yong Huang, Guang-lei Zhao, Changquan Liu
Total hip arthroplasty (THA) is a well developed technique to which the spatial orientation of acetabular component is crucial. Since the idea of "safe zone" being proposed, such idea has long been obeyed by hip surgeons but has also been challenged in recent years. This is because post-operative instability could happen even if acetabular components are placed within "safe zone" . The latest researches have demonstrated that sagittal spinal balance and spino-pelvic mobility can affect the spatial orientation of acetabular components. Factors including spinal degenerative changes, long lumbosacral changes and spinal ankyloses can lead to sagittal spinal imbalance and/or influence spino-pelvic mobility, which subsequently affect pelvic retroversion. Proper pelvic retroversion is a way to compensate for sagittal spinal imbalance and is beneficial to post-operative stability. It is necessary for hip surgeons to rethink "safe zone" before performing THA and understand spinal balance as well as spinopelvic mobility. The goal is to reduce the rate of dislocation. This review started by introducing the related spinopelvic parameters frequently seen in papers published recently and the definitions of acetabular cup orientations. After the spinal sagittal balance and its compensatory mechanisms session, discussed its clinical relevance, as well as the significance of spinal mobility, in spinopelvic motion under three different postures.
全髋关节置换术(THA)是一项成熟的技术,其中髋臼部件的空间定位至关重要。自从“安全地带”的概念被提出以来,一直为髋关节外科医生所遵循,但近年来也受到了挑战。这是因为即使髋臼部件放置在“安全区域”内,术后也可能发生不稳定。最新研究表明,矢状面脊柱平衡和脊柱-骨盆活动可以影响髋臼部件的空间取向。包括脊柱退行性改变、长腰骶改变和脊柱强直在内的因素可导致矢状面脊柱失衡和/或影响脊柱-骨盆活动,从而影响骨盆后倾。适当的骨盆后倾是一种补偿矢状椎体不平衡的方法,有利于术后稳定。髋关节外科医生在进行全髋关节置换术前有必要重新思考“安全区域”,了解脊柱平衡和脊柱骨盆活动。目标是降低脱位率。本文首先介绍了最近发表的论文中常见的相关骨盆参数和髋臼杯取向的定义。在脊柱矢状面平衡及其代偿机制的讨论之后,讨论了三种不同体位下脊柱骨盆运动中矢状面平衡及其代偿机制的临床意义以及脊柱活动度的意义。
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引用次数: 0
Clinical characteristics and pathogenic gene analysis in a large pedigree with multiple epiphyseal dysplasia 多发性骨骺发育不良大家系的临床特点及致病基因分析
Q4 Medicine Pub Date : 2020-01-16 DOI: 10.3760/CMA.J.ISSN.0253-2352.2020.02.005
Guiyu Lou, Na Qi, Ke Yang, Litao Qin, Yuwei Zhang
Objective To provide experimental evidence for genetic counseling and prenatal molecular diagnosis by analyzing the clinical characteristics and screening for pathogenic genes of a five-generation suspected multiple epiphyseal dysplasia (MED) family (17 patients). Methods The family members' medical history, general physical examination and hip joint X-ray examination were collected. Peripheral blood samples of the family members were collected and DNA were extracted from these samples. The exons of clinical genes from probands' DNA were sequenced by High throughput sequencing method. Next Gene software was used to compare and analyze the sequence and INGENUITY software was further used to annotate the mutations in order to find the pathogenic mutations in probands. The suspicious mutations were confirmed in pedigree members by PCR and Sanger sequencing. Results The family consisted of 5 generations and 38 members. Pedigree analysis was consistent with autosomal dominant inheritance. There were 17 patients in the family, and their clinical manifestations showed abnormal walking posture in childhood, pain in hip and knee joints, and typical pathological changes of epiphyseal dysplasia on X-ray. Cartilage oligomeric matrix protein (COMP) gene c.1153G>A (p.Asp385Asn) missense heterozygous mutation was screened in proband, which was genotypically and phenotypically segregated in the pedigree. Conclusion A missense mutation of the comp gene has been identified in a pedigree affected with MED which was the first reported in a big family. Our result is conducive to the further diagnosis and treatment and also provides a molecular basisfor the future prenatal diagnosis. Key words: Osteochondrodysplasias; Pedigree; DNA, intergenic; DNA mutational analysis
目的分析疑似多发性骨骺发育不良(MED)家族5代(17例)患者的临床特征及致病基因筛选,为遗传咨询和产前分子诊断提供实验依据。方法收集患者家属病史、全身检查及髋关节x线检查资料。采集家族成员外周血样本,提取DNA。采用高通量测序法对先证者DNA的临床基因外显子进行测序。利用Next Gene软件对序列进行比对分析,并用INGENUITY软件对突变进行注释,寻找先证者的致病突变。可疑突变通过PCR和Sanger测序在家系成员中得到证实。结果该家族共5代38人。家谱分析与常染色体显性遗传一致。家族共有17例患者,临床表现为童年行走姿势异常,髋关节、膝关节疼痛,x线表现为典型的骨骺发育不良病理改变。软骨寡聚基质蛋白(COMP)基因c.1153G >a (p.Asp385Asn)错义杂合突变在先显子中筛选,在家系中进行基因型和表型分离。结论在一个MED家系中发现了comp基因的错义突变,这是在一个大家庭中首次报道的。我们的结果有利于进一步的诊断和治疗,也为未来的产前诊断提供了分子基础。关键词:骨软骨发育不良;血统;DNA,基因间的;DNA突变分析
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引用次数: 0
The clinical outcomes of percutaneous self-expanding forceful reduction screw system for the treatment of thoracolumbar fracture with severe loss of vertebral height 经皮自膨胀强力复位螺钉系统治疗胸腰椎骨折伴严重椎体高度缺失的临床疗效
Q4 Medicine Pub Date : 2019-12-16 DOI: 10.3760/CMA.J.ISSN.0253-2352.2019.24.004
Biao Wang, Jian Chen, Haiping Zhang, Simin He, Qinpeng Zhao, Lingbo Kong, Yuhang Wang, H. Meng, D. Hao
Objective To explore the safety and effectiveness of a novel percutaneous self-expanding forceful reduction screw system in the treatment of thoracolumbar fracture with severe vertebral height loss. Methods Thirty-eight patients of thoracolumbar fracture with more than 50%vertebral height loss were treated with the novel percutaneous self-expanding forceful reduction screw between March 2014 and June 2015. The screw system is a single plane screw with a reduction angle of 0,3,6,9 degrees. During the operation, the fracture vertebral body was automatically restored during the locking process of the top cap. All the patients were single vertebral fractures. Percutaneous screw fixation and reduction was used in the operation. Two groups of screws were used to fix the two adjacent vertebrae of the injured vertebra and to restore the injured vertebral body, without fusion treatment. The vertebral body index (VBI), height of the anterior margin of fractured vertebra (HAMFV), vertebral body angle (VBA), bisegmental Cobb angle (BCA), visual analog scale (VAS) and Oswestry disability index (ODI) of the patients before and after operation, 6 months after operation, and at the end of the follow-up were compared. The scoring results were compared using a t test. Results The operation was completed successfully in 38 cases. A total of 152 screws were placed. The accuracy rate of CT evaluation was 98.7%. The average operation time was 90.7±21.9 min, and the average intraoperative bleeding amount was 89.2±31.9 ml. The patients' preoperative VBI, HAMFV, VBA, BCA, VAS and ODI scores were 0.38±0.07, 0.38±0.06, 25.45°±4.54°, 18.66°±8.57°, 7.76±1.02, and 44.58%±2.33%, respectively. The postoperative measurements were 0.93±0.03, 0.95±0.02, 3.71°± 1.35°, 5.84°±6.80 °, 4.29±1.16 and 24.37%±1.88%. At the last follow-up, the measurements were 0.92±0.03, 0.94±0.02, 3.89° ±1.31°,6.05°±7.00°, 1.71±0.65 and 5.95%±2.67%. There was significant difference between the preoperative and postoperative data, as well as the preoperative and the last follow-up data (P<0.05). Conclusion In the treatment of thoracolumbar fractures with severe loss of vertebral height, the novel percutaneous self-expanding forceful reduction screw system has achieved satisfactory vertebral height restoration and kyphosis correction. Key words: Thoracic vertebrae; Lumbar vertebrae; Spinal fractures; Surgical procedures, minimally invasive; Internal fixators
目的探讨新型经皮自膨胀强力复位螺钉系统治疗胸腰椎骨折伴严重椎体高度丢失的安全性和有效性。方法2014年3月至2015年6月对38例椎体高度损失大于50%的胸腰椎骨折患者采用新型经皮自膨胀强力复位螺钉治疗。螺杆系统为单平面螺杆,减速角为0、3、6、9度。术中,骨折椎体在顶帽锁定过程中自动复位。所有患者均为单椎体骨折。手术采用经皮螺钉固定复位。采用两组螺钉固定损伤椎体相邻两椎体,恢复损伤椎体,不进行融合治疗。比较两组患者手术前后、术后6个月及随访结束时的椎体指数(VBI)、骨折前缘高度(HAMFV)、椎体角(VBA)、半节段Cobb角(BCA)、视觉模拟评分(VAS)和Oswestry残疾指数(ODI)。评分结果采用t检验进行比较。结果38例手术顺利完成。共置入152颗螺钉。CT评价准确率为98.7%。平均手术时间90.7±21.9 min,平均术中出血量89.2±31.9 ml。患者术前VBI、HAMFV、VBA、BCA、VAS、ODI评分分别为0.38±0.07、0.38±0.06、25.45°±4.54°、18.66°±8.57°、7.76±1.02、44.58%±2.33%。术后测量值分别为0.93±0.03、0.95±0.02、3.71°±1.35°、5.84°±6.80°、4.29±1.16和24.37%±1.88%。末次随访时测量值分别为0.92±0.03、0.94±0.02、3.89°±1.31°、6.05°±7.00°、1.71±0.65和5.95%±2.67%。术前与术后、术前与末次随访数据比较,差异均有统计学意义(P<0.05)。结论新型经皮自扩式强力复位螺钉系统在治疗胸腰椎骨折伴严重椎体高度丢失的病例中,取得了满意的椎体高度恢复和脊柱后凸矫正效果。关键词:胸椎;腰椎;脊柱骨折;外科手术,微创;内部固定器
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引用次数: 0
The clinical research progress of neck muscle tensity detection methods and evaluation index 颈部肌肉张力检测方法及评价指标的临床研究进展
Q4 Medicine Pub Date : 2019-12-16 DOI: 10.3760/CMA.J.ISSN.0253-2352.2019.24.006
Shuang Yang
Cervical muscle group has complex anatomical and physiological characteristics, which plays an important role in maintaining cervical stability and participating in cervical activity. Long-term bow of the head will cause irreversible injury to the neck muscle. The clinical manifestations are stiffness of the neck, and increased muscle tension. In severe cases, muscle spasms are like stripes. The pain caused by it for more than 3 months is called chronic neck pain(CNP). With the increasing incidence of chronic neck pain in the population, the related case reports and clinical studies are also increasing. At present, it is generally believed that persistent non-autonomous hypertension of neck muscle is the primary pathological mechanism of chronic neck pain. For the objective, quantitative analysis and evaluation of neck muscle tension is helpful to predict the occurrence of chronic neck pain, explain its pathogenesis and formulate treatment measures, which has gradually become the main development trend in this field. In recent years, with the development of auxiliary medicine, evaluation methods have changed with each passing day, which provides a variety of options for clinical research. In this paper, several mainstream detection methods of cervical muscle tension are summarized, and the shear wave elastography technology, surface electromyography, magnetic resonance imaging and diffusion tensor imaging are introduced respectively. Their development history, and the working principle of each technology aredescribed in detail. By reviewing the classical clinical research cases at domestic and abroad, the research status of each technology in the field of cervical muscle detection is deeply analyzed. The development trend, potential advantages and limitations of Yang's modulus, integrated electromyography, root mean square value, mean power frequency, median frequency, cross sectional area and apparent diffusion coefficient were evaluated. The purpose of this paper is to summarize experience, guide clinic, deepen the understanding of microcosmic pathogenesis of chronic neck pain, provide theoretical basis for exploring new detection methods, provide omni-directional, multi-level and three-dimensional new clinical diagnosis and treatment strategies for related fields, and provide new methods and ideas for the follow-up study of chronic neck pain.
子宫颈肌群具有复杂的解剖和生理特征,对维持子宫颈稳定性和参与子宫颈活动具有重要作用。长期低头会对颈部肌肉造成不可逆转的伤害。临床表现为颈部僵硬和肌肉张力增加。在严重的情况下,肌肉痉挛就像条纹一样。由它引起的超过3个月的疼痛被称为慢性颈部疼痛(CNP)。随着人群中慢性颈部疼痛发生率的增加,相关病例报告和临床研究也在增加。目前普遍认为,颈肌持续性非自主性高血压是慢性颈痛的主要病理机制。从客观上讲,对颈部肌肉张力的定量分析和评估有助于预测慢性颈部疼痛的发生,解释其发病机制,制定治疗措施,逐渐成为该领域的主要发展趋势。近年来,随着辅助医学的发展,评价方法日新月异,为临床研究提供了多种选择。本文综述了几种主流的颈部肌肉张力检测方法,并分别介绍了剪切波弹性成像技术、表面肌电图、磁共振成像和扩散张量成像。详细介绍了它们的发展历史,以及每种技术的工作原理。通过回顾国内外经典临床研究案例,深入分析了各技术在子宫颈肌检测领域的研究现状。评估了杨氏模量、积分肌电图、均方根值、平均功率频率、中值频率、横截面积和表观扩散系数的发展趋势、潜在优势和局限性。本文旨在总结经验,指导临床,加深对慢性颈部疼痛微观发病机制的认识,为探索新的检测方法提供理论依据,为相关领域提供全方位、多层次、立体化的临床诊疗新策略,为慢性颈痛的随访研究提供了新的方法和思路。
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引用次数: 0
Analysis of the demographic and clinical characteristics of hospitalized patients with osteoporotic vertebral compression fractures 骨质疏松性椎体压缩性骨折住院患者的人口学及临床特征分析
Q4 Medicine Pub Date : 2019-12-16 DOI: 10.3760/CMA.J.ISSN.0253-2352.2019.24.005
Bao-ting Zhang, Yunzhen Chen
Objective To analyzed demographic and clinical characteristics in hospitalized patients with osteoporotic vertebral compression fractures(OVCFs)and to provide certain evidence for prevention and treatment of the disease. Methods Retrospectively analyzedthe clinical data of 2 028 patients with OVCF from January 2009 to December 2018 in the Spine Department of Qilu Hospital of Shandong University. The trend of composition ratio and average age of OVCF patients in the past ten years were observed, the differences of the demographic characteristics and clinical characteristics between different genders as well as the correlation between the number of fractured vertebral bodies of OVCF and various influencing factors were analyzed, and the characteristics of OVCF inpatients were summarized. Results Of 2 028 patients, 374 were males and 1654 were females.The average age was 70.50±9.73 years old, and the male is 73.29±10.23 and the female is 69.87±9.46. A significant increase in the constituent ratio of OVCF between 2009 and 2018 (6.85% in 2009 vs. 13.24% in 2013) and the mean age of OVCF patients increased from 67.54±9.92 years in 2009 to 70.96±9.63 years in 2018were identified.There were significant differences in age distribution of OVCFs in different gender. When the age was less than 70 years old,the fracture ratio of female was higher than that of males, especially between 60 and 70 years old (38.63%∶17.91%); However, when the age was more than 70 years, the fracture ratio of male was higher than that of female especially after 80 years old(29.15%:12.70%). There were significant differences in occupation distribution of OVCFs indifferent gender. Peasants (47.94%), professionals (18.32%) and workers (14.63%) were the top three in female while peasants (35.56%), workers (26.47%) and professionals(20.05%) in male. Falling was the main injury cause of OVCF and there were significant differences in the distribution of causes of OVCF injuries between different genders. The proportion of traffic accident injuries infemaleswas higher than that in maleswhile the proportion of sprains inmaleswas higher than that in females.Moreover,there was a statistically significant difference in the distribution of fracture vertebral bodies between patients of different ages, with or without fracture history and smoking history and different ages of menopause.Among them, the number of fractured vertebral bodies was positively correlated with age(r=0.79, P<0.05).The composition ratio of single vertebral fracture of patients without fracture history, menopausal ageunder 50 and withoutsmoking history was higher than that with fracture history, menopausal age over 50 and with smoking history. On the contrary,the composition ratio of two or more vertebral fractures in patients without fracture history and menopausal agebelow 50 was lower than thatwith fracture history and menopausal ageover 50. Particularly, the ratio of three or more vertebral fractures with sm
目的分析骨质疏松性椎体压缩性骨折(OVCF)住院患者的人口学和临床特点,为该病的预防和治疗提供一定的依据。方法回顾性分析2009年1月至2018年12月在山东大学齐鲁医院脊柱科就诊的2 028例OVCF患者的临床资料。观察了近十年来OVCF患者的组成比例和平均年龄的变化趋势,分析了不同性别的人口学特征和临床特征的差异,以及OVCF椎体骨折数量与各种影响因素的相关性,总结了OVCF住院患者的特点。结果2 028例患者中,男性374例,女性1654例。平均年龄70.50±9.73岁,男性73.29±10.23岁,女性69.87±9.46岁。2009年至2018年间,OVCF的构成比显著增加(2009年为6.85%,2013年为13.24%),OVCF患者的平均年龄从2009年的67.54±9.92岁增加到2018年的70.96±9.63岁。不同性别OVCF的年龄分布存在显著差异。当年龄小于70岁时,女性的骨折率高于男性,尤其是在60~70岁之间(38.63%∶17.91%);但70岁以上男性骨折率高于女性,尤其是80岁以后(29.15%:12.70%),不同性别OVCF的职业分布存在显著差异。农民(47.94%)、专业人员(18.32%)和工人(14.63%)是女性的前三位,而农民(35.56%)、工人(26.47%)和专业人员(20.05%)是男性。跌倒是OVCF的主要损伤原因,不同性别OVCF损伤原因的分布存在显著差异。男性交通事故伤害比例高于男性,扭伤比例高于女性。此外,不同年龄、有无骨折史、吸烟史和不同绝经年龄的患者骨折椎体的分布存在统计学显著差异。其中骨折椎体数与年龄呈正相关(r=0.79,P<0.05),无骨折史、绝经年龄在50岁以下、无吸烟史的患者单椎体骨折组成比高于有骨折史、更年期年龄在50以上、有吸烟史的。相反,没有骨折史且绝经年龄在50岁以下的患者,两个或两个以上脊椎骨折的组成比低于有骨折史且更年期年龄在50以上的患者。特别是有吸烟史的脊椎骨折三处或三处以上的比例高于无吸烟史的比例。2014年前采用骨密度(BMD)测试和骨转换因子测试的患者人数分别为118和106人,2014年后分别为568和837人,差异具有统计学意义。结论2009-2018年期间,OVCF在脊柱疾病中的比例和患者的平均年龄在逐渐增加。年龄、职业和损伤原因的分布与性别有关,但季节、骨折节段和合并症的分布和性别之间没有相关性。年龄、既往骨折史、女性更年期年龄和吸烟史与椎体骨折数量相关,饮酒史与骨折数量无关。关键词:骨质疏松症;脊柱骨折;人口特征;疾病属性
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引用次数: 0
Research progress in the application status and development trend of artificial intelligence in the diagnosis and treatment of spinal disease 人工智能在脊柱疾病诊治中的应用现状及发展趋势的研究进展
Q4 Medicine Pub Date : 2019-12-16 DOI: 10.3760/CMA.J.ISSN.0253-2352.2019.24.007
Hanqiang Ouyang, Liang Jiang, Xiaoguang Liu, Huishu Yuan, Zhongjun Liu
The cross-fusion research of artificial intelligence technology and spinal surgery represented by machine learning and neural network model is a new research direction and hot issue in the field of artificial intelligence in recent years. The anatomy and disease symptoms of the spine are complex, and the diagnosis and treatment of spinal surgery require rich clinical experience. However, the distribution of medical resources in China is seriously uneven. How to improve the ability of primary medical services so that the most extensive patient groups can benefitis still an urgent problem to be solved. Artificial intelligence is a technical science that researches and develops theories, methods, technologies, and application systems for simulating, extending and expanding human intelligence. With the advent of the era of big data medical technology, artificial intelligence technology may solve this problem by transforming "experts sinking" into "tech sinking" . At present, technologies such as confrontation learning, weakly supervised learning, intensive learning and graph neural networks have become research hotspots in the field of artificial intelligence, and have also played an important role in many fields of clinical medicine. Based on the advantages of deep learning and neural network in disease learning, many spine surgeons combine it with the diagnosis and treatment of cervical spondylosis, low back pain, lumbar degenerative diseases, spinal deformity, spinal tumors, and other spine-related diseases. The rapid location and accurate diagnosis of the disease not only makes it an effective tool for the comprehensive diagnosis of spinal diseases but also provides the basis for the most reasonable treatment options for spinal diseases. In the domestic application of artificial intelligence in the diagnosis and treatment of spinal surgery, it can also solve the problems of difficult diagnosis and complicated treatment of spinal diseases faced by primary doctors, reduce the rate of misdiagnosis and missed diagnosis, and effectively reduce the economic and social burden of spinal diseases. This paper reviews the research progress of artificial intelligence represented by deep learning in the field of diagnosis and treatment of spinal surgery at home and abroad, and the advantages and application prospects of artificial intelligence in the diagnosis and treatment of spinal surgery.
以机器学习和神经网络模型为代表的人工智能技术与脊柱外科的交叉融合研究是近年来人工智能领域的一个新的研究方向和热点问题。脊柱的解剖结构和疾病症状复杂,脊柱外科的诊断和治疗需要丰富的临床经验。但是,我国医疗资源的分布严重不均衡。如何提高基层医疗服务能力,使最广泛的患者群体受益,仍然是一个亟待解决的问题。人工智能是一门研究和开发用于模拟、扩展和扩展人类智能的理论、方法、技术和应用系统的技术科学。随着大数据医疗技术时代的到来,人工智能技术可能会通过将“专家下沉”转变为“技术下沉”来解决这个问题。目前,对抗学习、弱监督学习、强化学习和图神经网络等技术已成为人工智能领域的研究热点,在临床医学的许多领域也发挥了重要作用。基于深度学习和神经网络在疾病学习中的优势,许多脊柱外科医生将其与颈椎病、腰痛、腰椎退行性疾病、脊柱畸形、脊柱肿瘤和其他脊柱相关疾病的诊断和治疗相结合。该疾病的快速定位和准确诊断不仅使其成为综合诊断脊柱疾病的有效工具,而且为最合理的脊柱疾病治疗选择提供了依据。在国内人工智能在脊柱外科诊疗中的应用中,还可以解决基层医生面临的脊柱疾病诊断难、治疗复杂的问题,降低误诊漏诊率,有效减轻脊柱疾病的经济和社会负担。本文综述了以深度学习为代表的人工智能在国内外脊柱外科诊疗领域的研究进展,以及人工智能在脊柱外科诊疗中的优势和应用前景。
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引用次数: 1
Clinical diagnosis and surgical treatment of cervical spondylosis with distal upper extremity amyotrophy 颈椎病伴上肢远端肌萎缩症的临床诊断与手术治疗
Q4 Medicine Pub Date : 2019-12-16 DOI: 10.3760/CMA.J.ISSN.0253-2352.2019.24.003
Hongli Wang, Feizhou Lyu, Xiaosheng Ma, X. Xia
Objective To summarize the clinical features of cervical spondylosis with distal upper extremity amyotrophy; and further analyze the clinical efficacy of cervical anterior decompression and fusion on cervical spondylosis with distal upper extremity amyotrophy. Methods Thirty cases of cervical spondylosis with distal upper extremity amyotrophy were analyzed retrospectively from June 2006 to June 2015. nineteen males and eleven females with an average age of 55.20±9.08 years (41 to 72 years) were included. The preoperative course was 1 to 108 months with a median of 6 months. The muscle extent of the affected group, the segmentation and location of spinal canal stenosis, and the results of neurophysiological examination were analyzed. The muscular strength recovery of atrophic muscles was evaluated by Manual Muscle Testing (MMT), and the clinical satisfaction was assessed at the last followed up. Results The muscles involved in patients of cervical spondylosis with distal upper extremity amyotrophy are mainly the thenar muscle (17 cases, 56.7%), interosseous muscle (15 cases, 50.0%), and shypothenar muscles (13 cases, 43.3%). Most cases of imaging findings showed multi-segmental degeneration, of which C5, 6 (24 cases, 80.0%), C6,7 (21 cases, 70.0%) segments were most common, and the types of anterior compression: 23 segments (33.5%) of the central type, 37 segments (54.4%) of the lateral-central type, and 8 segments (11.8%) of the foramen type. Neuroelectrophysiological examination showed that cervical spinal cord anterior horn cells or nerve root damage, the most commonly involved segments of C7, C8, T1(18 cases, 60.0%). The average follow-up time was 36.8 months. At the last follow-up, MMT assessment showed that thirteen patients (43.3%) in this group had muscle strength recovery for more than one grade at the last follow-up. The average clinical satisfaction was 73.4%. Conclusion The clinical diagnosis of cervical spondylosis with distal upper extremity amyotrophy requires a combination of clinical symptoms, imaging findings and neurophysiological examination results for comprehensive judgment. Cervical anterior decompression and fusion can effectively prevent the progression of cervical spondylosis in distal upper extremity amyotrophy patients, and some patients can get a good muscle recovery. Key words: Cervical vertebrae; Spinal cord compression; Muscular atrophy; Spinal fusion
目的总结上肢远端肌萎缩型颈椎病的临床特点;并进一步分析颈前路减压融合术治疗上肢远端肌萎缩型颈椎病的临床疗效。方法对2006年6月至2015年6月收治的30例上肢远端肌萎缩型颈椎病患者进行回顾性分析。男19例,女11例,平均年龄55.20±9.08岁(41~72岁)。术前疗程为1-108个月,中位数为6个月。分析受累组的肌肉范围、椎管狭窄的分割和位置以及神经生理学检查结果。通过手动肌肉测试(MMT)评估萎缩肌肉的肌力恢复情况,并在最后一次随访时评估临床满意度。结果上肢远端肌萎缩型颈椎病患者累及的肌肉主要为鱼际肌(17例,56.7%)、骨间肌(15例,50.0%)和小鱼际肌肉(13例,43.3%),影像学表现多节段退变,其中C5、6节段(24例,80.0%)、C6,7节段(21例,70.0%)最为常见,前部压迫类型:中央型23节(33.5%),外侧-中央型37节(54.4%),孔型8节(11.8%)。神经电生理检查显示颈脊髓前角细胞或神经根损伤,最常见受累节段为C7、C8、T1(18例,60.0%),平均随访时间36.8个月。在最后一次随访中,MMT评估显示,该组中有13名患者(43.3%)在最近一次随访时肌肉力量恢复超过一个级别。结论上肢远端肌萎缩型颈椎病的临床诊断需要结合临床症状、影像学表现和神经生理学检查结果进行综合判断。颈前路减压融合术可有效预防上肢远端肌萎缩患者的颈椎病进展,部分患者可获得良好的肌肉恢复。关键词:颈椎;脊髓压迫;肌肉萎缩;脊柱融合术
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引用次数: 0
New PRUNUS spine plate system and its biomechanical research and preliminary clinical application 新型PRUNUS脊柱钢板系统及其生物力学研究与初步临床应用
Q4 Medicine Pub Date : 2019-12-16 DOI: 10.3760/CMA.J.ISSN.0253-2352.2019.24.002
Detai Qi, Xiaofeng Zhao, Yi-Bo Zhao, Xiang-dong Lu, Xu Yang, Xiao-nan Wang, Run-tian Zhou, Yuan-zhang Jin
Objective To develop a new type of triple-leaf-enhanced cervical spine plate system, to study its biomechanical properties, perform clinical preliminary applications, and observe clinical effects. Methods Twelve fresh goat specimens were used, and the high-precision digital display grating displacement sensor system was used to compare the stability, fatigue strength and tensile strength of the fixation of the anterior nailing of the new type of triple-leaf-enhanced cervical spine plate system. All of 92 patients with cervical spondylosis who underwent cervical anterior decompression, cage or titanium mesh fusion, with new PRUNUS spine plate system or Atlantis spine plate system internal fixation were selected from January 2015 to January 2018. Comparative study recorded intraoperative blood loss, operative time, preoperative cervical Cobb angle, pain visual analogue scale (VAS), and Japanese Orthopaedic Association (JOA) spinal function score, and neurological improvement ratewas calculated. Frankel grading was used to evaluate pre and postoperative functional status of the anterior and posterior nerves, so as to comprehensively evaluate the initial clinical efficacy of the new PRUNUS spine plate system. Results The biomechanical tests showed that: 1) The flexion, extension, left bending, right bending, left rotation and right rotation ROM after fixing with the new PRUNUS spine plate system were 1.02°±0.13°, 1.32°±0.11°, 0.96°±0.23°, 1.03°±0.19°, 1.37°±0.17° and 1.05°±0.08°. ROM after fixation of Atlantis spine plate system were 0.99°±0.11°, 1.08°±0.23°, 0.83°±0.21°, 0.82°±0.13°, 1.18°±0.43°, 1.17°±0.17°, respectively. There was no significant statistical difference between the two groups; 2) The fatigue life of the new PRUNUS spine plate system and Atlantis spine plate system were 6.3×105 and 6.1×105, and the fatigue strengths were 512.12 Mpa and 502.85 Mpa respectively. There was no statistical difference between the two groups. 3) The maximum pull-out force of the new PRUNUS spine plate system was 483.62±39.14 N, and the maximum pull-out force of the Atlantis spine plate system was 396.55±22.79 N. The difference between the two groups was statistically significant. In the clinical application, the new PRUNUS spine plate system was used, the average operation time was 102.8±13.6 min, and the average blood loss was 56.8±14.1 ml. Using the Atlantis spine plate system, the average operation time was 132.8±15.7 min, and the average blood loss was 76.8±19.1 ml. The difference between the two groups was statistically significant; Using the new PRUNUS spine plate system, the VAS score was reduced from 5.42±1.17 before surgery to 1.58±0.44, the preoperative JOA score was 8.13±1.26, and the JOA score was 14.71±1.16 at the last follow-up. Using the Atlantis spine plate system, the VAS score was 6.94±1.06 before surgery. dropped to 1.75±0.35, the preoperative JOA score was 9.26±1.32, and the JOA score was 14.96±1.56 at the last follow-up. Th
目的研制一种新型三叶增强颈椎钢板系统,研究其生物力学性能,进行临床初步应用,观察临床效果。方法采用12只新鲜山羊标本,采用高精度数显光栅位移传感器系统,比较新型三叶增强颈椎钢板系统前钉固定的稳定性、疲劳强度和抗拉强度。选取2015年1月至2018年1月间行颈椎前路减压、cage或钛网融合、新型PRUNUS脊柱钢板系统或Atlantis脊柱钢板系统内固定的92例颈椎病患者。对比研究记录术中出血量、手术时间、术前颈椎Cobb角、疼痛视觉模拟评分(VAS)、日本骨科协会(JOA)脊柱功能评分,并计算神经系统改好率。采用Frankel分级法评价前后神经的术前和术后功能状态,综合评价新型PRUNUS脊柱钢板系统的初步临床疗效。结果生物力学试验表明:1)新型PRUNUS脊柱钢板系统固定后屈伸、左屈、右屈、左旋、右旋ROM分别为1.02°±0.13°、1.32°±0.11°、0.96°±0.23°、1.03°±0.19°、1.37°±0.17°和1.05°±0.08°。Atlantis脊柱钢板系统固定后ROM分别为0.99°±0.11°、1.08°±0.23°、0.83°±0.21°、0.82°±0.13°、1.18°±0.43°、1.17°±0.17°。两组间差异无统计学意义;2)新型PRUNUS脊柱板系统和Atlantis脊柱板系统的疲劳寿命分别为6.3×105和6.1×105,疲劳强度分别为512.12 Mpa和502.85 Mpa。两组间无统计学差异。3)新型PRUNUS脊柱钢板系统的最大拔出力为483.62±39.14 N, Atlantis脊柱钢板系统的最大拔出力为396.55±22.79 N,两组差异有统计学意义。在临床应用中,采用新型PRUNUS脊柱钢板系统,平均手术时间为102.8±13.6 min,平均出血量为56.8±14.1 ml。采用Atlantis脊柱钢板系统,平均手术时间为132.8±15.7 min,平均出血量为76.8±19.1 ml,两组差异有统计学意义;使用新型PRUNUS脊柱钢板系统,VAS评分由术前的5.42±1.17降至1.58±0.44,术前JOA评分为8.13±1.26,末次随访时JOA评分为14.71±1.16。采用Atlantis脊柱钢板系统,术前VAS评分为6.94±1.06。术前JOA评分为9.26±1.32,末次随访时JOA评分为14.96±1.56。两组间无显著差异。结论新型PRUNUS脊柱钢板系统具有良好的生物力学性能,对颈椎的稳定性有良好的效果,尤其适用于术后修复和骨质疏松患者。操作简单方便,安全有效,值得临床推广。关键词:颈椎;内部固定器;生物力学;治疗结果
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引用次数: 0
Clinical effects of the implantation of porous tantalum rod under three-dimensional C-arm positioning in treating ARCO I-II non-traumatic necrosis of the femoral head 三维c臂定位下多孔钽棒植入术治疗ARCO I-II型非外伤性股骨头坏死的临床效果
Q4 Medicine Pub Date : 2019-12-01 DOI: 10.3760/CMA.J.ISSN.0253-2352.2019.23.004
Rui Luo, Guomin Li, B. Liu, Bo Li, X. Tian, Hu Ruyin
Objective To evaluate the clinical effects of the implantation of porous tantalum rod under three-dimensional (3D) C-arm positioning in the treatment of ARCO I and II non-traumatic femoral head necrosis. Methods Fifty patients (58 hips, 39 males and 11 females, mean age 33.52 years) with non-traumatic femoral head in ARCO I-II were included from January 2009 to December 2011. All patients received implantation of porous tantalum rod. The 3D C-arm X-ray positioning was used in 24 patients (29 hips), while traditional C-arm X-ray positioning was performed in the other patients. The visual analogue scale (VAS), Harris score and superior rate were evaluated at 0.5, 1, 2, and 4 years after the surgery. Total hip arthroplasty was regarded as the end event for survival rate. Results In the 3D C-arm X-ray positioning group, the VAS score decreased from 7.17±1.00 points preoperatively to 2.38±0.86 points at half year, to 2.10±1.40 points at 1 year, to 2.38±1.66 points at 2 years, and to 2.21±1.47 points at 4 years postoperatively (F=98.78, P=0.00). Meanwhile, the Harris score increased significantly from 73.97±3.49 points preoperatively to 89.90±1.93, 89.93±3.26, 89.21±5.83, 88.57±5.70 points at the follow up, respectively (F=84.35, P=0.00). According to the analysis of the pre-operative and post-operative image data, there was no significant difference in progress in the ARCO staging at 23 hips duration the follow-up. Four hips were developed to ARCO III and two hips to ARCO II. Thus, the success rate of operation was 79% (23/29). There were two hips underwent total hip arthroplasty, so the survival rate of femoral head was 93% (27/29). The trend of VAS score and Harris score in the C-arm X-ray positioning group was in accordance with the 3D C-arm X-ray positioning group but without statistically significant difference (P>0.05). The operation duration 31.38±3.96 min, blood loss 36.72±5.59 ml, the ratio of distance of metal rod to bone cortex in femoral neck 0.48±0.10, and the distance of mental rod to center of necrosis 0.18±0.07 cm in 3D C-arm X-ray positioning group was superior to C-arm X-ray positioning group (respectively 41.97±4.64 min, 41.49±4.46 ml, 0.46±0.06, 0.23±0.10 cm, P<0.05). Conclusion The implantation of tantalum rod in treating ARCO I-II non-traumatic femoral head necrosis can increase the function of hip joint, relieve the symptoms of necrosis of femoral head, alleviate the progress of femoral head necrosis in X-ray, and obtain a higher survival rate. The 3D C-arm positioning in surgical operation could improve the accuracy and safety of surgery. Key words: Femur head necrosis; Tantalum; Imaging, three-dimensional; X-rays; Radiography
目的探讨三维(3D) c臂定位下多孔钽棒植入术治疗ARCO型和II型非外伤性股骨头坏死的临床效果。方法2009年1月至2011年12月对50例非外伤性股骨头患者(58髋,男39例,女11例)进行回顾性分析,平均年龄33.52岁。所有患者均行多孔钽棒植入术。24例患者(29髋)采用三维c臂x线定位,其余患者采用传统c臂x线定位。分别于术后0.5年、1年、2年、4年评估视觉模拟评分(VAS)、Harris评分及优胜率。全髋关节置换术被认为是生存率的终点事件。结果三维c臂x线定位组VAS评分由术前7.17±1.00分降至半年2.38±0.86分,1年2.10±1.40分,2年2.38±1.66分,4年2.21±1.47分(F=98.78, P=0.00)。Harris评分由术前的73.97±3.49分上升至随访时的89.90±1.93分、89.93±3.26分、89.21±5.83分、88.57±5.70分(F=84.35, P=0.00)。根据术前和术后影像资料分析,随访期间23髋的ARCO分期进展无显著差异。四个髋关节发展到ARCO III,两个髋关节发展到ARCO II。手术成功率为79%(23/29)。2髋行全髋关节置换术,股骨头成活率93%(27/29)。c臂x线体位组VAS评分和Harris评分趋势与3D c臂x线体位组一致,但差异无统计学意义(P < 0.05)。三维c臂x线定位组手术时间31.38±3.96 min,出血量36.72±5.59 ml,股骨颈金属棒距骨皮质距离0.48±0.10,金属棒距坏死中心距离0.18±0.07 cm(分别为41.97±4.64 min, 41.49±4.46 ml, 0.46±0.06,0.23±0.10 cm, P<0.05)优于c臂x线定位组。结论钽棒植入术治疗ARCO I-II型非外伤性股骨头坏死可增加髋关节功能,缓解股骨头坏死症状,缓解x线股骨头坏死进展,获得较高生存率。三维c型臂在手术中的定位可以提高手术的准确性和安全性。关键词:股骨头坏死;钽;三维成像;x射线;射线照相法
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