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Literature review of the relationship and relative factors between anterior knee pain and patellofemoral joint after total knee arthroplasty 全膝关节置换术后膝关节前侧疼痛与髌股关节的关系及相关因素的文献综述
Q4 Medicine Pub Date : 2019-12-01 DOI: 10.3760/CMA.J.ISSN.0253-2352.2019.23.008
Changzhao Li, Jiarong Chen
Anterior knee pain continues to be a major problem following total knee arthroplasty (TKA). Patellofemoral joint is closely associated to the occurrence of the anterior knee pain, so it is also called patellofemoral joint pain. Overstuff of patellofemoral joint and patella maltracking are the main factors for anterior part of the post-operative pain. They are resulted from the change of native morphology and Q angle of patellofemoral joint after operation. Instead of non-modifiable patients' congenital and genetic factors, they are mainly related to the improper surgical techniques and the mismatch between prostheses and native patellofemoral morphology. The reason of the mismatch is that the prosthesis is unable to cover all kinds of differences of the patellofemoral morphology among races and genders. In addition, some surgical techniques, including patellar replacement, circumpatellar denervation, femoral and patellar prostheses location, and the selection of the type of prosthesis, also affect the occurrence of anterior knee pain. The above mentioned factors may eventually lead to excessive and uneven distribution of the patella-femoral loads, which would compress and simulate the peripheral nerves around the joint. Ultimately, they result in the anterior knee pain. Therefore, the following effective strategies could lead to relief anterior knee pain and improve patients overall satisfaction after TKA, including improvements of prostheses design, patellar resurfacing, circumpatellar denervation, infrapatellar fat padpreservation or using mobile-bearing rotating-platform.
膝前疼痛仍然是全膝关节置换术(TKA)后的主要问题。髌股关节和膝关节前部疼痛的发生密切相关,故也称髌股关节疼痛。髌股关节过度拥挤和髌骨移位是造成术前疼痛的主要因素。这是由于术后髌股关节固有形态和Q角的改变所致。与不可改变的患者先天和遗传因素无关,主要与手术技术不当以及假体与固有髌股形态不匹配有关。错配的原因是假体无法覆盖不同种族和性别的髌股形态的各种差异。此外,一些手术技术,包括髌骨置换术、髌骨周围神经支配、股骨和髌骨假体的位置以及假体类型的选择,也会影响膝前疼痛的发生。上述因素最终可能导致髌骨-股骨负荷的过度和不均匀分布,从而压缩和模拟关节周围的外周神经。最终,它们会导致膝关节前部疼痛。因此,以下有效策略可以缓解TKA后膝关节前疼痛,提高患者的整体满意度,包括改进假体设计、髌骨表面置换、髌骨周围神经支配、髌下脂肪垫保存或使用移动轴承旋转平台。
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引用次数: 0
The strategy selection of surgical approach and decompression and fusion for cervical spondylotic myelopathy 脊髓型颈椎病手术入路及减压融合术的策略选择
Q4 Medicine Pub Date : 2019-12-01 DOI: 10.3760/CMA.J.ISSN.0253-2352.2019.23.009
X. Guan
Cervical spondylotic myelopathy is a common and frequently-occurring disease in Orthopaedics, especially with multi-segmental cervical spondylotic myelopathy. There are several pathogenic factors for cervical spondylotic myelopathy. The clinical symptoms are serious, and the imaging manifestations are complex. Most of them are accompanied by serious neurological damage, which seriously affects the quality of life of patients. Furthermore, some patients have serious cervical spinal cord injury symptoms, which endanger their lives after mild trauma. Therefore, early diagnosis, early treatment and surgery are the most effective methods at present, which could effectively eliminate the factors of spinal cord compression and reconstruct the stability of cervical spine function. However, the choice of surgical approach and decompression fusion has always been the focus of debate. The primary purpose of surgery for cervical spondylotic myelopathy is to completely relieve the compression of spinal cord. According to the imaging characteristics of cervical spondylotic myelopathy, it is the key to the success of the operation to determine the decompression and reconstruction of cervical spondylotic myelopathy. Anterior approach can be adopted in patients with the compression factors located in front of the spinal cord, including disc protrusion, mild osteophyte or local ossification posterior longitudinal ligament, less lesion segments, small compression range, cervical kyphosis or local kyphosis deformity, easy resection of compression and sagittal imbalance correction. Decompression fusion can be selected through intervertebral space, subtotal vertebral body resection and mixed decompression for fusion and fixation. In order to retain the active function of cervical vertebrae, artificial disc replacement and fusion can be selected. For patients with the compression factors located in the posterior part of the spinal cord, including ligamentumflavum hypertrophy or ossification, congenital developmental spinal canal stenosis, there are many factors causing compression in front of the spinal cord. The range is larger, the lesion segment is longer. Thus, it is difficult to resect thoroughly in front of the spinal cord with higher risk of anterior surgery. Although the posterior approach is indirect decompression with the help of posterior spinal cord movement, it plays a good role in improving nerve function with fewer complications and relatively higher safety. There are absolute surgical indications and relative indications for two approaches. Combining anterior and posterior surgery has advantages of complete decompression and strong fixation. However, it has the advantages of great trauma and high risk, so it is necessary to apply it in clinical practice. Moreover, no matter how to choose the approach, we should use perfect imaging data combined with clinical symptoms and signs to clarify the pathological factors of spinal cord com pression, the severity
脊髓型颈椎病是骨科常见病和多发病,尤其是多节段脊髓型颈椎疾病。脊髓型颈椎病有几个致病因素。临床症状严重,影像学表现复杂。它们大多伴有严重的神经损伤,严重影响患者的生活质量。此外,一些患者在轻度创伤后会出现严重的颈脊髓损伤症状,危及生命。因此,早诊断、早治疗、早手术是目前最有效的方法,可以有效消除脊髓压迫因素,重建颈椎功能的稳定性。然而,手术入路和减压融合的选择一直是争论的焦点。脊髓型颈椎病手术的主要目的是完全缓解对脊髓的压迫。根据脊髓型颈椎病的影像学特点,确定脊髓型颈椎病变的减压重建是手术成功的关键。对于压迫因素位于脊髓前方的患者,可采用前路入路,包括椎间盘突出、轻度骨赘或后纵韧带局部骨化、病变节段少、压迫范围小、颈后凸或局部后凸畸形、容易切除压迫和矢状位不平衡矫正。减压融合术可选择椎间隙、椎体次全切除和混合减压进行融合固定。为了保持颈椎的主动功能,可以选择人工椎间盘置换融合。对于压迫因素位于脊髓后部的患者,包括黄韧带肥大或骨化、先天性发育性椎管狭窄,有许多因素导致脊髓前部压迫。范围越大,病变节段越长。因此,在脊髓前部进行彻底切除是困难的,前路手术的风险更高。尽管后入路是借助脊髓后部运动的间接减压,但它在改善神经功能方面发挥了良好的作用,并发症较少,安全性相对较高。两种入路有绝对手术指征和相对指征。前后联合手术具有减压彻底、固定牢固的优点。然而,它具有创伤大、风险高的优点,因此有必要将其应用于临床。此外,无论如何选择入路,我们都应该使用完善的影像学数据,结合临床症状和体征,明确脊髓压迫的病理因素、脊髓损伤的严重程度、压迫的范围和责任段,并制定个性化的手术计划。
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引用次数: 0
Comparing the efficacy of core decompression with autologous bone marrow mononuclear cell grafting with impacted bone grafting in treating bilateral femoral head necrosis 自体骨髓单个核细胞植入术与阻生植骨术治疗双侧股骨头坏死的疗效比较
Q4 Medicine Pub Date : 2019-12-01 DOI: 10.3760/CMA.J.ISSN.0253-2352.2019.23.003
Qingyu Zhang, F. Gao, L. Cheng, Wei Sun, Zi-rong Li
Objective To compare the efficacy of core decompression with autologous bone marrow mononuclear cell grafting with impacted bone grafting in treating bilateral femoral head necrosis. Methods From January 2011 to January 2017, a total of 44 patients with bilateral femoral head necrosis (88 hips) were admitted to the Department of Orthopaedics, China-Japan Friendship Hospital, including 35 males and 9 females with aged 34.9±7.2 years old (ranged from 22-48 years). Core decompression with autologous bone marrow mononuclear cell and impacted bone grafting were conducted to each hip joint for every patient. All patients were followed up for every 3 months at the first year postoperatively and for every 6 months thereafter. The following clinical measurement were recorded, Harris hip score (HHS), visual analogue score (VAS), the anterior-posterior and frog lateral radiographs, and CT. The 5-year survival rate of the hip was calculated with the endpoint event being defined as a need for total hip arthroplasty or other surgical intervention, or a HHS less than 70. Results The postoperative follow-up duration was 50.5±34.2 months in the impacted bone grafting group and 54.0±33.1 months in the core decompression with autologous bone marrow mononuclear cells group. Fifteen hips in the impacted bone grafting group and 13 hips in the core decompression with autologous bone marrow mononuclear cell group failed during the follow-up. The 5-year cumulative survival rates of the hips in two groups were 64.7% and 72.1%, respectively [HR=1.178, 95%CI(0.561, 2.477)]. In the impacted bone grafting group, the 5-year survival rates of the hip joints at the ARCO IIIB+IIIC and IIIA stages were 42.9% and 74.2%, respectively [HR=3.258, 95%CI(1.172, 9.059)]. In the core decompression with autologous bone marrow mononuclear cell group, the 5-year survival rates of hips at the ARCO stage I, II and IIIA stages were 50.0%, 75.3%, and 71.4%, respectively (χ2=0.757, P=0.685). Age, gender, BMI, preoperative HHS and etiology did not affect the effects of core decompression with autologous bone marrow mononuclear cell grafting or impacted bone grafting (P>0.05). The preoperative VAS of the impacted bone grafting group and the core decompression with autologous bone marrow mononuclear cell grafting group were 4.80±0.62 and 3.27±1.17, respectively (t=8.625, P<0.001). At the last follow-up, the VAS was reduced to 2.84±1.95 and 2.25±2.08, respectively (t=2.712, P=0.01; t=7.087, P<0.001) with significant difference in postoperative VAS between the two groups (t=2.489, P=0.017). The preoperative HHS of the impacted bone grafting group and the core decompression with autologous bone marrow mononuclear cell grafting group were 77.02±5.03 and 82.57±5.71, respectively (t=7.822, P<0.001). At the last follow-up, the HHS increased to 81.57±12.81 and 83.55±12.87, respectively. The difference between the preoperative and postoperative HHS was statistically significant in the impacted b
目的比较髓核减压联合自体骨髓单个核细胞移植和阻生骨移植治疗双侧股骨头坏死的疗效。方法自2011年1月至2017年1月,共有44例双侧股骨头坏死(88髋)患者入住中日友好医院骨科,其中男性35例,女性9例,年龄34.9±7.2岁(22-48岁)。对每位患者的每个髋关节进行自体骨髓单个核细胞核心减压和阻生骨移植。所有患者术后第一年每3个月随访一次,术后每6个月随访。记录以下临床测量结果,Harris髋关节评分(HHS)、视觉模拟评分(VAS)、前后和蛙侧位X线片以及CT。计算髋关节的5年生存率,终点事件定义为需要全髋关节置换术或其他手术干预,或HHS小于70。结果阻生骨移植组的术后随访时间为50.5±34.2个月,自体骨髓单个核细胞核心减压组的随访时间为54.0±33.1个月。阻生骨移植组15髋,自体骨髓单个核细胞核心减压组13髋随访失败。两组髋关节的5年累积生存率分别为64.7%和72.1%[HR=1.178,95%CI(0.561,2.477)]。在阻生骨移植组中,ARCO IIIB+IIIC和IIIA期髋关节的五年生存率分别是42.9%和74.2%[HR=3.258,95%CI(1.172,9.059)],ARCO I期、II期和IIIA期髋关节的5年生存率分别为50.0%、75.3%和71.4%(χ2=0.757,P=0.685),术前HHS和病因对自体骨髓单个核细胞移植或阻生骨核心减压的效果无影响(P>0.05)。阻生骨移植组和自体骨髓单个细胞移植核心减压组术前VAS分别为4.80±0.62和3.27±1.17,末次随访VAS分别降至2.84±1.95和2.25±2.08,两组术后VAS差异有统计学意义(t=2.489,P=0.017)。阻生骨移植组和自体骨髓单个核细胞移植核心减压组术前HHS分别为77.02±5.03和82.57±5.71(t=7.822,P<0.001),HHS分别增加到81.57±12.81和83.55±12.87。阻生骨移植组的术前和术后HHS差异有统计学意义(t=2.389,P=0.021),而自体骨髓单个核细胞移植核心减压组的差异无统计学意义(t=0.451,P=0.654)自体骨髓单个核细胞移植和髓核减压是治疗股骨头坏死安全有效的方法。ARCO分期是影响阻生骨移植术后髋关节预后的危险因素,对自体骨髓单核细胞移植核心减压后髋关节的中期生存没有影响。关键词:股骨头坏死;骨移植;自体移植;骨髓移植
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引用次数: 1
Significance of enhanced MRI in evaluating the prognosis of early Perthes disease MRI增强对早期Perthes病预后评价的意义
Q4 Medicine Pub Date : 2019-12-01 DOI: 10.3760/CMA.J.ISSN.0253-2352.2019.23.005
Zhang Huadong, Yang Jianping, Zhang Zhongli, Fu Zhe
Objective To investigate the reproducibility of the femoral head perfusion index by enhanced MRI and the predictive value of the Herring lateral pillar classification after the progression of early stage of Perthes disease (X-ray modified Waldenstrom stage Ia, Ib, IIa) to stage IIb. Methods From October 2016 to November 2018, a total of 30 children with early stage of Perthes disease were enrolled, including 29 males and 1 female, aged 7.5±1.0 years (range 6.3 to 9.5 years). All patients were evolved by unilateral with left 24 cases and 6 cases on the right side. There were 1 case in stage Ia, 16 cases in stage Ib and 13 cases in stage IIa. At the initial evaluation, X-ray films and enhanced MRI were performed. Three observers measured the femoral head perfusion index on the enhanced MRI. The ratio of the pixels in the affected ossified nucleus perfusion area to the pixels in the contralateral femoral skull nucleus was recorded. A total of 30 cases were measured with repeated evaluation at intervals of 1 to 2 weeks. The second measurement was independent of the first measurement results. The average of the two measurements was regarded as the final measurement results. At 3 months follow-up, anteroposterior and Lauenstein frog-lateral radiographs were taken. The follow-up duration was end at the stage IIb progression. The Herring lateral pillar of the femoral head was determined on the X-ray films. The differences in the early MRI femoral head perfusion index were compared between the different lateral column types. Results The ICC values of the femoral head perfusion index between the three observers were 0.876. The ICC values measured by the 1/3 perfusion index of the lateral femoral head were 0.729. The ICC values of the femoral head perfusion index measured by the same observer at different times were 0.932. The ICC values measured by the 1/3 perfusion index of the lateral femoral head were 0.805. A total of 30 children were followed to stage IIb at 6.49±5.12 months (range 2.3 to 22.1 months). There were 13 cases of type A and type B and 17 cases of type C. The sputum perfusion index of type A and type B was 59.77%±17.12% (range 25%-85%), and that of group C was 13.47%±10.65% (range 2%-23%). The difference between groups was statistically significant (t=8.563, P=0.000). The 1/3 perfusion index of the lateral femoral head of the A and B groups was 75.62%±15.03% (range 50%-95%), while the C type was 22.24%±12.28% (range 5%-45%) with significant difference (t=10.621, P=0.000). Conclusion The measurement of femoral head perfusion index on enhanced MRI has almost perfect agreement between and within observers across multiple rounds of study. In children with early Perthes disease, enhanced MRI has predictive effect on the Herring lateral pillar classification after progression to stage IIb. Key words: Magnetic resonance imaging; Subtraction technique; Child; Femur head necrosis; Forecasting
目的探讨增强MRI股骨头灌注指数的可重复性以及Herring侧柱分类对Perthes病早期(X射线改良Waldenstrom Ia、Ib、IIa期)发展为IIb期的预测价值。方法从2016年10月至2018年11月,共有30名早期Perthes病儿童入选,其中男性29名,女性1名,年龄7.5±1.0岁(6.3至9.5岁)。所有患者均为单侧进化,左侧24例,右侧6例。Ia期1例,Ib期16例,IIa期13例。在最初的评估中,进行了X光片和增强MRI检查。三名观察者在增强MRI上测量股骨头灌注指数。记录受累骨化核灌注区的像素与对侧股颅骨核的像素的比率。总共测量了30个病例,每隔1到2周进行一次重复评估。第二次测量与第一次测量结果无关。两次测量的平均值被视为最终测量结果。在3个月的随访中,拍摄了青蛙前后侧位和劳恩斯坦侧位X线片。随访时间在IIb阶段结束。在X线片上确定了股骨头的赫林侧柱。比较不同侧柱类型的早期MRI股骨头灌注指数的差异。结果三位观察者股骨头灌注指数ICC值为0.876。通过股骨头外侧的1/3灌注指数测量的ICC值为0.729。同一观察者在不同时间测量的股骨头灌注指数的ICC值为0.932。通过股骨头外侧1/3灌注指数测量的ICC值为0.805。共有30名儿童在6.49±5.12个月(2.3至22.1个月)时进入IIb期。A、B型13例,C型17例。A、B组痰灌注指数为59.77%±17.12%(范围25%-85%),C组为13.47%±10.65%(范围2%-23%)。A、B两组股骨头外侧1/3灌注指数分别为75.62%±15.03%(范围50%-95%),C型为22.24%±12.28%(范围5%-45%),差异有统计学意义(t=10.621,P=0.000)。在患有早期Perthes病的儿童中,增强MRI对进展到IIb期后的Herring侧柱分类具有预测作用。关键词:磁共振成像;减法技术;儿童;股骨头坏死;预测
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引用次数: 0
Animal models and research on preventions and treatments of steroid-associated osteonecrosis of the femoral head 类固醇相关性股骨头坏死的动物模型及防治研究
Q4 Medicine Pub Date : 2019-12-01 DOI: 10.3760/CMA.J.ISSN.0253-2352.2019.23.007
Xinluan Wang, L. Zheng, Huijuan Cao, L. Qin
Steroid associated-osteonecrosis (SAON) is non-trauma induced osteonecrosis, which is induced by long-term or high dose of corticosteroid indicated for inflammatory or immune diseases, etc. Subchondral collapse at late stage of SAON usually needs to be treated with joint replacement, while the costs and the prognosis of the surgery are challenge. It is important to perform the fundamental researches on the hip preservation treatments of SAON at early stage, and it is necessary to establish suitable animal models for studying the mechanisms of SAON and evaluating the potential treatments for the SAON. Rabbit SAON model is the most frequently used animal model. It is extensively used in studies on etiology and pathology of SAON. Furthermore, it is possible to evaluate potential drugs for preventing SAON and improving osteogenic repair of mid-stage SAON to prevent joint collapse. Because of bi-pedal, emu has the similar mechanical properties with human. Thus, it can be a suitable animal model for studying preventions and treatments of subchondral collapse of SAON, such as core-decompression with biodegradable materials for bone regeneration. In conclusion, this review updates the current animal SAON models with similar pathology to clinical SAON. These typical models could be used as clinical references for investigating drugs in prevention of early-stage of SAON and biomaterials in hip-preservation surgery for mid-stage of SAON.
类固醇相关性骨坏死(SAON)是一种非创伤性骨坏死,是指长期或大剂量皮质类固醇治疗炎症性或免疫性疾病等引起的骨坏死。SAON晚期软骨下塌陷通常需要进行关节置换术治疗,但手术的费用和预后都是一个挑战。早期开展SAON髋关节保留治疗的基础研究是十分重要的,建立合适的动物模型是研究SAON发生机制和评估SAON治疗方法的必要条件。兔SAON模型是最常用的动物模型。广泛应用于SAON的病因和病理研究。此外,还可以评估预防SAON和改善中期SAON成骨修复以防止关节塌陷的潜在药物。由于是双足行走,鸸鹋具有与人相似的机械性能。因此,它可以成为研究SAON软骨下塌陷的预防和治疗方法的合适动物模型,如生物降解材料进行骨再生的核心减压。总之,这篇综述更新了目前与临床SAON病理相似的动物SAON模型。这些典型模型可作为研究早期预防SAON的药物和中期SAON保髋手术生物材料的临床参考。
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引用次数: 1
One-stage treatment of hip dislocation with cerebral palsy via soft tissue release, hip reduction and osteotomy 软组织松解、髋关节复位、截骨术一期治疗脑瘫伴髋关节脱位
Q4 Medicine Pub Date : 2019-12-01 DOI: 10.3760/CMA.J.ISSN.0253-2352.2019.23.006
Z. Bian, Yuan Guo, Gang Xu, Jie Yang, Jiangli Zhang, X. Lyu, Zheng Yang
Objective To investigate the methods and outcomes of surgical treatment for hip dislocation with cerebral palsy (CP) via soft tissue release, hip reduction and osteotomy. Methods Nineteen CP patients (male: 9, female: 10; total 23 hips) with hip dislocation underwent reconstructive surgery between April 2010 and December 2016. The average age was 12.5±2.4 years. There were 17 diplegic, 1 hemiplegic and 1 quadriplegic patient. Gross motor function classification system distribution were type I in 2 patients, type II in 10 patients, type III in 5 patients, type IV in 2 patients. Combine one-stage surgical procedures included soft tissue release, close or open reduction of hip joint and femoral varus shortening or de-rotational osteotomy and pelvic osteotomy. During the follow-up period, the clinical symptom and radiological parameters including Sharp angle and acetabular index were recorded. Results The average follow-up duration was 2.1 years (1-4.5 years). The radiological parameters were evaluated at one year postoperatively. The migration percentage corrected to 6%±8% from 68%±21% with statistically significant different (t=12.760, P<0.001). The mean Sharp angle was 42°±8.9°, which was statistically significant reduced compared with the pre-operative value 59°±6.1° (t=9.058, P<0.001). In 15 patients with triradiate cartilage open, the acetabular index also improved from 34°±8.7° pre-operatively to 18°±10° with statistical significance (t=5.598, P<0.001). Total of 15 patients had gained hip stability and improved functional status. Hip pain, which happened in 11 patients preoperatively, all had relieved after operation. Four patients had dissatisfied results and re-subluxation happened in 3 hips. All of them had CE angle <20° immediately after operation (average, 17°±2.6°), which was significantly different compared with average CE angle 32°± 8.0° in non-recurrence hips (t=3.143, P=0.005). One patient, who underwent proximal hamstring release, had decline of function status and contralateral hip dislocation. Conclusion Dislocation hips in CP patients can be effectively treated with one stage soft tissue release, hip reduction and femoral and pelvic osteotomy. The selection of osteotomy method is based on the age and pathological changes of patients. Key words: Cerebral palsy; Hip dislocation; Osteotomy
目的探讨软组织松解、髋关节复位、截骨治疗脑瘫髋关节脱位的方法和疗效。方法在2010年4月至2016年12月期间,19例CP患者(男9例,女10例,共23髋)接受了髋关节脱位的重建手术。平均年龄12.5±2.4岁。其中双瘫17例,偏瘫1例,四肢瘫痪1例。毛运动功能分类系统分布为I型2例,II型10例,III型5例,IV型2例。联合一期手术包括软组织松解、髋关节闭合或开放复位、股内翻缩短或去旋转截骨和骨盆截骨。在随访期间,记录临床症状和放射学参数,包括锐角和髋臼指数。结果平均随访2.1年(1-4.5年)。术后一年评估放射学参数。迁移率从68%±21%校正为6%±8%,差异有统计学意义(t=12.760,P<0.001)。平均锐角为42°±8.9°,与术前59°±6.1°(t=9.058,P<001)相比有统计学意义,髋臼指数也从术前的34°±8.7°提高到18°±10°,具有统计学意义(t=5.598,P<0.001)。共有15例患者获得了髋关节稳定性和功能状态的改善。术前发生的11例髋关节疼痛,术后均得到缓解。4例患者结果不满意,3例髋关节再次半脱位。所有患者术后即刻CE角<20°(平均17°±2.6°),与非复发髋关节的平均CE角32°±8.0°相比有显著差异(t=3.143,P=0.005)。结论一期软组织松解、髋关节复位、股骨及骨盆截骨可有效治疗CP患者髋关节脱位。截骨方法的选择是基于患者的年龄和病理变化。关键词:脑瘫;髋关节脱位;截骨术
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引用次数: 0
Prevention and early treatments of steroid-induced osteonecrosis of the femoral head 类固醇性股骨头坏死的预防与早期治疗
Q4 Medicine Pub Date : 2019-12-01 DOI: 10.3760/CMA.J.ISSN.0253-2352.2019.23.001
Dewei Zhao
With the heavily application of steroid in the clinic, the incidence of steroid-induced osteonecrosis of the femoral head is also rapidly increasing. It is generally believed that steroid-induced osteonecrosis of the femoral head is the result of a various of pathological mechanisms. Clinical evidence suggests that the occurrence of osteonecrosis is highly correlated with the daily mean dose and cumulative dose of steroid. Patients don't always have osteonecrosis of the femoral head which may be related to the susceptibility of individual genes to steroid. Steroid-induced osteonecrosis of the femoral head is divided into three stages by pathomorphological, indicating the early, middle and late stage of blood supply changes. With the change of blood supply, the range of osteonecrosis is gradually increasing, and eventually leads to collapses. The earlier the osteonecrosis is found, the more selective the treatments regimen are. The prognosis will be often better with early diagnosis. Regulating the use of steroid can reduce the occurrence of osteonecrosis. Thus, we emphasize that the use of steroid in clinical settings should be cautious and regulated. Digital subtraction angiography can be used to assess early osteonecrosis of the femoral head. According to the assessment of progression of disease, the drug or the corresponding surgical procedure will be selected. Steroid-induced osteonecrosis of the femoral head can achieve good clinical results through early detection and early treatments.
随着类固醇在临床上的大量应用,类固醇引起的股骨头坏死的发生率也在迅速增加。一般认为类固醇诱导的股骨头坏死是多种病理机制的结果。临床证据表明,骨坏死的发生与类固醇的日平均剂量和累积剂量高度相关。患者并不总是股骨头坏死,这可能与个别基因对类固醇的易感性有关。激素诱导的股骨头坏死按病理形态学可分为三个阶段,提示早期、中期和晚期的血液供应变化。随着血液供应的变化,骨坏死的范围逐渐增大,最终导致塌陷。骨坏死发现得越早,治疗方案的选择性就越强。早期诊断往往会使预后更好。调节类固醇的使用可以减少骨坏死的发生。因此,我们强调在临床环境中使用类固醇应该谨慎和规范。数字减影血管造影术可用于评估股骨头早期坏死。根据对疾病进展的评估,将选择药物或相应的手术程序。激素诱导的股骨头坏死,通过早发现、早治疗,可以取得良好的临床效果。
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引用次数: 0
Preserving hip treatment of steroid-induced osteonecrosis of the femoral head 类固醇性股骨头坏死的保髋治疗
Q4 Medicine Pub Date : 2019-12-01 DOI: 10.3760/CMA.J.ISSN.0253-2352.2019.23.002
Wei-min Fu, Bao‐yi Liu, Ben-Jie Wang
Objective To investigate the early diagnosis and treatment options for steroid-induced osteonecrosis of the femoral head (SONFH). Methods Retrospective analysis was conducted in 73 patients with unilateral SONFH from January 2010 to June 2017. There were 27 males and 46 females, aged 34.26±10.35 years (range, 20-45 years). The following type of cases were included, 21 cases of ARCO I, 24 cases of IIa, 8 cases of IIb, 18 cases of IIc and 2 cases of IIIa. Patients with ARCO I were limited in weight and were treated with low molecular weight heparin sodium and ginkgo dharma drugs after excluding bleeding risk. Core decompression was performed in patients with ARCO IIa and IIb vascularized greater trochanter bone transfer was conducted in patients with IIc and IIIa. During the follow-up duration, when the ARCO I progressed to ARCO IIa and IIb, the core decompression was performed. When the ARCO IIa and IIb progressed to the ARCO IIc or IIIa, the vascularized greater trochanter bone transfer was conducted. Vascularized greater trochanter bone combined with the tantalum rod was implanted in ARCO IIIb. The femoral head reconstruction with the larger trochanter bone flap or joint replacement was performed in ARCO IIIc and above. The Harris hip score was used to evaluate the clinical outcomes. The femoral head survival curve of SONFH was drawn with the end of joint replacement. Results All 73 patients were followed up for an average of 29 months (range, 18 to 48 months). After treatment of 21 patients with ARCO I, a total of 14 (67%) patients had no ARCO staging progress. After 6 months, three patients progressed to ARCO IIb and 4 patients progressed to ARCO IIc. All 32 patients with ARCO IIa and IIb were treated, of which 25 (78%) did not progress but 4 patients progressed to ARCO IIIa at 6 months. Only one patient progressed to ARCO IIIb at 6 months, and 2 patient progressed to ARCO IIIc at 12 months. There were 18 patients with ARCO IIc underwent treatment, of which 14 patients (78%) did not progress but 2 patients progressed to ARCO IIIa at 6 months and 2 patients progressed to ARCO IIIc at 24 months and to ARCO IV at 42 months, respectively. Two patients of ARCO IIIa, 1 patient did not progress and the other one progressed to ARCO IV at 36 months. The Harris hip score was 90.48±5.36 before treatment and 91.76±8.19 at the last follow-up. The difference was not statistically significant (t=1.231, P=0.402). The Harris hip score of patients with ARCO IIa and IIb in creased from 75.22±8.30 to 84.47±16.77 with statistically significant difference (t=5.624, P<0.001). The Harris hip score of patients with ARCO IIc and IIIa increased from 59.80±9.24 to 77.75±20.75 with statistically significant difference (t=12.033, P<0.001). Four patients eventually underwent arthroplasty. The femoral head survival rate was 98.6% at 2 years and 94.5% at 4 years. Conclusion The SONFH can be diagnosed early by screening, and is treated by different reserving
目的探讨类固醇性股骨头坏死(SONFH)的早期诊断和治疗方案。方法对2010年1月至2017年6月73例单侧SONFH患者进行回顾性分析。男性27例,女性46例,年龄34.26±10.35岁,年龄范围20 ~ 45岁。ARCO I型21例,IIa型24例,IIb型8例,IIc型18例,IIIa型2例。ARCO I型患者体重受限,排除出血风险后给予低分子肝素钠和银杏达摩药物治疗。IIa和IIb型ARCO患者行核心减压,IIc和IIIa型患者行血管化大转子骨转移。在随访期间,当ARCO I进展到ARCO IIa和IIb时,进行核心减压。当ARCO IIa和IIb进展到ARCO IIc或IIIa时,进行带血管的大转子骨转移。带血管的大转子骨联合钽棒植入ARCO IIIb。大转子骨瓣股骨头重建或关节置换术在ARCO IIIc及以上进行。Harris髋关节评分用于评估临床结果。随关节置换术结束,绘制SONFH股骨头存活曲线。结果73例患者平均随访29个月(18 ~ 48个月)。21例ARCO I患者治疗后,共有14例(67%)患者没有ARCO分期进展。6个月后,3例进展为ARCO IIb, 4例进展为ARCO IIc。所有32例ARCO IIa和IIb患者均接受治疗,其中25例(78%)未进展,但4例患者在6个月时进展为ARCO IIIa。只有1例患者在6个月时进展为ARCO IIIb, 2例患者在12个月时进展为ARCO IIIc。18例ARCOⅱ型患者接受了治疗,其中14例(78%)未进展,但2例患者在6个月时进展为ARCOⅱ型,2例在24个月时进展为ARCOⅱ型,2例在42个月时进展为ARCOⅳ型。2例ARCO IIIa, 1例未进展,1例在36个月时进展为ARCO IV。Harris髋关节评分治疗前为90.48±5.36,末次随访时为91.76±8.19。差异无统计学意义(t=1.231, P=0.402)。ARCO IIa和IIb患者Harris髋关节评分由75.22±8.30上升至84.47±16.77,差异有统计学意义(t=5.624, P<0.001)。ARCO IIc、IIIa患者Harris髋关节评分由59.80±9.24分升高至77.75±20.75分,差异有统计学意义(t=12.033, P<0.001)。4名患者最终接受了关节置换术。股骨头2年生存率为98.6%,4年生存率为94.5%。结论SONFH可通过筛查早期诊断,并根据严重程度采取不同的保留髋关节治疗方法。近期临床效果满意。关键词:糖皮质激素;股骨头坏死;游离组织瓣;减压、外科
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引用次数: 1
Experimental research on the change of subchondral bone microstructure in early stage of mouse osteoarthritis 小鼠骨关节炎早期软骨下骨微结构变化的实验研究
Q4 Medicine Pub Date : 2019-11-16 DOI: 10.3760/CMA.J.ISSN.0253-2352.2019.22.005
Yonghui Dong, Ang Li, Z. Dai, Shengjie Wang, Wendi Zheng, Weiyu Pan, Yi Jin, Ke Liu, Jiajun Zhao
Objective To establish a mouse model of osteoarthritis (OA) and study the bone microarchitecture and bone metabolism of tibial subchondral bone in early stage of OA. Methods The mouse model of post-traumatic osteoarthritis (PTOA) with anterior cruciate ligament (ACLT) was established by using c57 mice. The Sham operation group served as the control group. All mice were fed with conventional diet. All mice were sacrificed after 4 weeks. The degeneration of knee joint was observed by HE staining and Safranin O-Fast Green staining. The number of osteoclasts was counted by TRAP staining. Micro CT was used to analyze the quantitative parameters of the microstructure of tibia subchondral bone in mice. Serum levels of bone resorption biomarker CTX I and cartilage degeneration marker CTX II were determined. Results After ACLT 4 weeks, the average score of OARSI in ACLT group was 3.2, which was higher than that in Sham group, and the joint degeneration occurred in mice, presenting the pathological characteristics of early OA. Compared with the sham operation phase, the total subchondral bone volume (TV) of ACLT group was 4.72 mm3, increased by 13.6%; the bone trabecular resolution (Tb.Sp) was 0.130 and 0.154 mm, respectively, and the ACLT group also increased by 18.8%; the bone volume/tissue volume (BV/TV) was 0.470 and 0.294, respectively, and the ACLT group decreased by 48.9%; the bone trabecular thickness (Tb.Th) was 0.162 and 0.083 mm groups, ACLT decreased by 37.5%. Trap staining showed that the number of osteoclasts per unit volume in ACLT group was 72, which was significantly higher than that in sham operation group. The CTX I of mice in the sham operated ACLT group and sham operated group were 20.9 ng/ml and 18.29 ng/ml, with an increase of 48.9% in the ACLT group; the CTX II of mice in the ACLT group and sham operated group were 35.5 ng/ml and 28.6 ng/ml, with an increase of 24.1% in the ACLT group. Conclusion ACLT Mouse model can successfully construct early OA, which confirms the early loss of osteochondral bone and the pathological changes of osteoclast activation in OA, and provides a new specific target for the treatment of OA. Key words: Anterior cruciate ligament; Osteoarthritis; Cartilage, articular; Osteoclasts
目的建立小鼠骨关节炎(OA)模型,研究OA早期胫骨软骨下骨的微结构和骨代谢。方法采用c57小鼠建立前交叉韧带损伤后骨关节炎(PTOA)小鼠模型。Sham手术组作为对照组。所有小鼠均采用常规饮食喂养。4周后处死所有小鼠。HE染色和番红O-Fast Green染色观察膝关节退变。通过TRAP染色计数破骨细胞的数量。采用显微CT对小鼠胫骨软骨下骨显微结构的定量参数进行分析。测定骨吸收生物标志物CTX I和软骨变性标志物CTX-II的血清水平。结果ACLT 4周后,ACLT组的OARSI平均得分为3.2,高于Sham组,小鼠出现关节变性,呈现早期OA的病理特征。与假手术期相比,ACLT组软骨下总骨体积(TV)为4.72mm3,增加13.6%;骨小梁分辨率(Tb.Sp)分别为0.130和0.154mm,ACLT组也增加了18.8%;骨体积/组织体积(BV/TV)分别为0.470和0.294,ACLT组下降48.9%;Trap染色显示,ACLT组单位体积破骨细胞数为72个,明显高于假手术组。假手术组和假手术组小鼠的CTX I分别为20.9ng/ml和18.29ng/ml,ACLT组增加48.9%;ACLT组和假手术组小鼠的CTX II分别为35.5ng/ml和28.6ng/ml,ACLT组增加24.1%。结论ACLT小鼠模型能够成功构建早期OA,证实了OA骨软骨骨的早期丢失和破骨细胞活化的病理变化,为OA的治疗提供了新的特异性靶点。关键词:前交叉韧带;骨关节炎;软骨,关节;破骨细胞
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引用次数: 0
Arthroscopic treatment of Cam-type femoroacetabular impingement 关节镜下治疗Cam型股骨髋臼撞击
Q4 Medicine Pub Date : 2019-11-16 DOI: 10.3760/CMA.J.ISSN.0253-2352.2019.22.007
Shuang Cong, Shaohua Liu, Yaying Sun, Zheci Ding
Femoroacetabular impingement (FAI) is a common cause of hip pain and limited range of motion among young and middle-aged active adults and athletes. The acetabular labral tear and cartilage damage secondary to FAI may increase the risk of hip osteoarthritis. FAI is characterized by pathologic impact between the femoral headneck junction and the acetabular rim secondary to bony deformity. According to the pathological anatomy leading to impingement, the FAI can be divided into the femoral cam-type deformity (Cam), the acetabular over-coverage deformity (Pincer) and a combination of both. In recent years, arthroscopic osteoplasty of the femoral head-neck junction is the main way to treat the Cam deformity; However, there still remain some controversies about how to perform an adequate and effective arthroscopic femoroplasty. Based on this problem, the present article reviewed the preoperative diagnosis, intraoperative evaluation, surgical techniques and postoperative evaluation of Cam-type FAI to explore how to adequately correct Cam deformity under arthroscopy. In the present study, a total of 1928 related articles were obtained by searching PubMed, Web of Science, Cochrane library, China Knowledge Network, Wanfang Full-text Database and Weipu Science and Technology Journal Database. According to the inclusion and exclusion criteria, 43 papers were finally included. After summarizing the above literatures, it was found that anatomical structures such as Cam deformity, femoral neck anteversion, and acetabular coverage can be evaluated preoperatively by X-ray, three-dimensional CT and MRI. X-ray fluoroscopy and arthroscopic dynamic examination are performed during the femoroplasty to locate the Cam deformity and to determine whether the femoral neck offset radio and the spherical structure of femoral head are corrected, at the same time, it is necessary to consider the overall anatomy of the hip joint to achieve an adequate resection of the Cam deformity and restore the normal mobility of the hip joint.
股骨髋臼撞击(FAI)是青壮年和中年活跃的成年人和运动员髋关节疼痛和活动范围受限的常见原因。髋臼唇撕裂和软骨损伤继发于FAI可增加髋骨关节炎的风险。FAI的特点是继发于骨畸形的股骨头颈交界处和髋臼缘之间的病理性冲击。根据导致撞击的病理解剖,FAI可分为股骨凸轮型畸形(Cam)、髋臼过度覆盖畸形(Pincer)以及两者的组合。近年来,关节镜下股骨头颈交界处成形术是治疗Cam畸形的主要方法;然而,如何进行充分有效的关节镜股骨成形术仍存在一些争议。针对这一问题,本文对Cam型FAI的术前诊断、术中评价、手术技术及术后评价进行综述,探讨如何在关节镜下充分矫正Cam畸形。本研究通过检索PubMed、Web of Science、Cochrane图书馆、中国知识网、万方全文库和卫普科技期刊库,共获得相关文献1928篇。根据纳入和排除标准,最终纳入43篇论文。综合以上文献,我们发现术前可通过x线、三维CT及MRI对凸轮畸形、股骨颈前倾、髋臼覆盖等解剖结构进行评估。股骨头成形术中通过x线透视和关节镜下的动态检查定位Cam畸形,确定股骨颈偏置和股骨头球形结构是否得到矫正,同时需要考虑髋关节的整体解剖结构,以达到充分切除Cam畸形,恢复髋关节的正常活动能力。
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引用次数: 1
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中华骨科杂志
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