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Development and Validation of New Analytical Method for the Determination of Particle Size Distribution in Glimepiride Using Laser Based Particle Size Analyzer 激光粒度分析仪测定格列美脲中粒径分布新方法的建立与验证
Q4 Multidisciplinary Pub Date : 2019-01-01 DOI: 10.33805/2576.8484.160
A. Gosar, Shivaji Jadhav, V. Patil, S. Folane, A. Jadkar, T. Vispute
Particle size is a key factor for modern drug quality since it affects the bioavailability and dissolution profile of the drug product. Study for Particle size is helpful to optimize drug product development process and improve the quality of drugs. In Order to determine the particle size of Glimepiride a novel and accurate Particle size determination method has been developed for the determination of particle size distribution of Glimepiride was described in this paper. This method has shown good reproducible results. By using water as dispersant wet method is developed and validated as per International conference on Harmonization guidelines (Q2 (R1)) and found out robust and reproducible with % RSD of d (10), d (50) and d (90) values found within acceptance limit ranges from 6.05% to 21.84% for d(0.1), 3.04% to 9.87% for d(0.5) and 4.69% to 14.32% for d(0.9) in validation. The described method is accurate and validated and successfully applied for the determination of particle size distribution of Glimepiride. Particle size method is discussed in detail to ensure in-depth understanding of particle size distribution and particle size method performance during lifetime of the product.
颗粒大小是现代药品质量的关键因素,因为它影响药品的生物利用度和溶出度。粒径的研究有助于优化药品开发工艺,提高药品质量。为了测定格列美脲的粒度,本文提出了一种新的、准确的格列美脲粒度测定方法。该方法重复性好。通过使用水作为分散剂,根据国际协调会议指南(Q2 (R1))开发和验证了湿法,并发现了稳健和可重复性,其RSD为d(10), d(50)和d(90)值的% RSD在可接受范围内,d(0.1)为6.05%至21.84%,d(0.5)为3.04%至9.87%,d(0.9)为4.69%至14.32%。该方法准确、有效,可用于格列美脲粒度分布的测定。详细讨论了粒度方法,以确保深入了解粒度分布和粒度方法的性能在产品的生命周期。
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引用次数: 0
Type 1 Diabetes Mellitus: Issues, Challenges and Opportunities 1型糖尿病:问题、挑战和机遇
Q4 Multidisciplinary Pub Date : 2018-12-08 DOI: 10.33805/2576-8484.156
Chrysanthus Chukwuma
Diabetes is one of the most intensively researched disorders presenting several metabolic alterations, but the basic biochemical aberrations or defects have not been clearly elucidated because the disorder is characteristically of autoimmune disposition. In addition, it is an intricately complex disease that exhibits disparate and distinct outlook and magnitude of pathology with grim susceptibility to gene-environment interactions. Early or invariable developments of deteriorating clinical alterations culminate in expansive socioeconomic costs. Adequate data regarding type 1 diabetes incidence have been from regions with a high or intermediate incidence, particularly in Europe and North America where numerous registries have since been established. There is a paucity of data from Africa Asia, the Caribbean, Central America and South America. The availability of veritable standardized type 1 diabetes incidence data from these low incidence regions is extremely crucial to establish that the presumed broad variation in incidence pertains, and that a low incidence in those regions is exact and not the resultant impact of underestimated incident cases.
糖尿病是研究最深入的疾病之一,表现出几种代谢变化,但基本的生化异常或缺陷尚未明确阐明,因为该疾病具有自身免疫性的特征。此外,它是一种复杂的疾病,表现出不同和不同的病理前景和程度,对基因-环境相互作用极为敏感。恶化的临床改变的早期或持续发展最终导致巨大的社会经济成本。关于1型糖尿病发病率的充分数据来自高发病率或中等发病率的地区,特别是欧洲和北美,那里已经建立了许多登记处。非洲、亚洲、加勒比、中美洲和南美洲的数据很少。从这些低发病率地区获得真正标准化的1型糖尿病发病率数据,对于确定假定的发病率的广泛变化是相关的,并且这些地区的低发病率是准确的,而不是低估的发病率所产生的影响至关重要。
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引用次数: 2
One to Many: A Framework for Scaling Risk Mitigation Assurance 一对多:扩展风险缓解保证的框架
Q4 Multidisciplinary Pub Date : 2018-12-08 DOI: 10.33805/2576-8484.155
Joel Bigley
The lack of vulnerability control leads to organizational harm in global businesses when the exploitation of a weakness occurs. How can a global supply chain protect itself from vulnerabilities that can damage their brand and their physical property? In this qualitative case study the author shows how a multi-site corporation can use a method to learn what the vulnerabilities are in a single facility and use a framework to methodically scale the controls needed to mitigate vulnerabilities across the supply chain. This framework allows leadership to keep cost in mind so that the highest vulnerabilities are mitigated as a priority. A team of security experts was used to capture data in framework used for analysis. This framework was then used strategically to reduce the overall risk of threat vectors in the global organization.
当弱点被利用时,缺乏漏洞控制会导致全球企业的组织伤害。全球供应链如何保护自己免受可能损害其品牌和实物财产的漏洞的影响?在这项定性案例研究中,作者展示了多站点公司如何使用一种方法来了解单个设施中的漏洞,并使用一个框架来有条不紊地扩展所需的控制,以缓解整个供应链中的漏洞。这一框架使领导层能够牢记成本,从而将缓解最高脆弱性作为优先事项。一个安全专家小组被用来捕获用于分析的框架中的数据。该框架随后被战略性地用于降低全球组织中威胁媒介的总体风险。
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引用次数: 0
Opinion Article: Articular Cartilage: Lamellar-Repulsive Lubrication of Natural Joints by Zenon Pawlak 观点文章:关节软骨:天然关节的板层排斥润滑,Zenon Pawlak
Q4 Multidisciplinary Pub Date : 2018-11-23 DOI: 10.33805/2576.8484.154
T. Kałdoński
This monograph attempts to explain a new joint lubrication mechanism with surface active phospholipids as a lubricant. It provides studies of the principles of cartilage (smart material) of biological micro- and Nano tribology.
这本专著试图解释一种以表面活性磷脂为润滑剂的新型关节润滑机制。它提供了生物微观和纳米摩擦学软骨(智能材料)原理的研究。
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引用次数: 0
The Effect of Social Media on the Spelling Ability of Students: A Case Study of Federal College of Education (FCE) Yola 社交媒体对学生拼写能力的影响:以联邦教育学院Yola为例
Q4 Multidisciplinary Pub Date : 2018-10-11 DOI: 10.33805/2576-8484.153
Fredrick Wilson
This research investigates social media effect on the spelling abilities of students of Federal College of Education Yola. The study is significant because it helped in unveiling the negative effect of social media on students spelling abilities. The intents of the study are to examine the effect of social media on the student’s spelling ability, to find out the nature of effect social media have on students spelling ability, to determine the number of hours spent by students on social networking activities every day and to determine how social media usage has affected students spelling ability. The social learning theory was adopted as the theoretical framework. Survey was the research method used, using questionnaire as the instrument which was conveniently and accidentally distributed among respondents in the levels. The study established that virtual platforms (social media) have negative effects on the spelling ability of students. Students expend excessive period on social media events than their academics especially the effect on the spelling ability of students during examination, when writing letters and using social media platform such as Whatsapp, Twitter and Facebook. The research generalized that the usage of social media by students affects their spelling ability negatively more especially when writing examination and letters, which in turn affects conventional way of writing. The study however recommends that more time should be channeled and spent on productive academic engagement and institutions should come up with ways of harnessing such virtual platforms academically in order to enhance students spelling ability since they are so addicted to social media.
本研究调查了社交媒体对尤拉联邦教育学院学生拼写能力的影响。这项研究意义重大,因为它有助于揭示社交媒体对学生拼写能力的负面影响。本研究的目的是考察社交媒体对学生拼写能力的影响,了解社交媒体对拼写能力影响的性质,确定学生每天在社交网络活动上花费的小时数,并确定社交媒体的使用如何影响学生的拼写能力。以社会学习理论为理论框架。调查是一种研究方法,以问卷为工具,方便而意外地在各级别的受访者中分发。研究表明,虚拟平台(社交媒体)对学生的拼写能力有负面影响。学生在社交媒体活动上花费的时间比他们的学术活动要长,尤其是在考试期间,在写信和使用Whatsapp、Twitter和Facebook等社交媒体平台时,这会对学生的拼写能力产生影响。研究表明,学生使用社交媒体对他们的拼写能力产生了更大的负面影响,尤其是在写考试和信件时,这反过来又影响了传统的写作方式。然而,这项研究建议,应该将更多的时间用于富有成效的学术参与,各机构应该想出在学术上利用这种虚拟平台的方法,以提高学生的拼写能力,因为他们对社交媒体如此着迷。
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引用次数: 7
Multiformity and Economic Importance of True Brachyuran Crabs 真Brachyun螃蟹的多样性及其经济意义
Q4 Multidisciplinary Pub Date : 2018-09-29 DOI: 10.33805/2576-8484.151
S. Rana
The brachyuran crabs are diversified and widely distributed habitant throughout the world, apart from Antarctica, they are reported from all the niches of network. They are dominant in all over estuaries and found in unfathomable depths of the Ocean down to 6000m and in the high mountains up to 3500 m above the sea level.Numerous species have evolved to lead terrestrial habitats. Mostly are in fresh water, and some of these crabs have evolved to survive as phytotelms, inside empty shells of the snails, within corals "symbiotically" or "commensally" and reported from alpine, caves and desert as well. Their sizes range from 2mm to 5.5mm; the weight ranges from few milligrams up to 19 kg. The fishery of the spanner crab, (Ranina ranina) has been thriving since World War II. People use crabs to cure different diseases: stomachache; liver and lungs diseases; healing wound; osteoporosis; and epilepsy and reproductive malfunction in women. This review aimed to find diversity and economic importance of crabs, which resulted positive and negative approaches. The crabs are multi-useful with diversified habitats, sizes and utility. Hence, it is suggested that the government should incorporate this in health care system into the existing one to ensure proper development and binding ethno-medicine in Nepal.
brachyuran螃蟹种类繁多,分布广泛,除南极洲外,在网络的各个生态位都有报道。它们在所有河口都占主导地位,在6000米以下的深不可测的海洋深处和海拔3500米以上的高山中都有发现。许多物种已经进化成为陆地栖息地的领头羊。这些螃蟹大多生活在淡水中,其中一些已经进化为植物群落,在蜗牛的空壳中,在珊瑚中“共生”或“共生”,在高山、洞穴和沙漠中也有报道。它们的尺寸从2mm到5.5mm不等;重量从几毫克到19公斤不等。扳手蟹(Ranina Ranina)的渔业自第二次世界大战以来一直蓬勃发展。人们用螃蟹来治疗不同的疾病:胃痛;肝脏和肺部疾病;愈合伤口;骨质疏松症;以及妇女的癫痫和生殖功能障碍。这篇综述旨在发现螃蟹的多样性和经济重要性,产生了积极和消极的方法。螃蟹具有多种用途,具有多样化的栖息地、大小和用途。因此,建议政府将其纳入现有的医疗保健系统,以确保尼泊尔的民族医学得到适当发展和约束。
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引用次数: 2
Role of Multimedia in Education 多媒体在教育中的作用
Q4 Multidisciplinary Pub Date : 2018-07-04 DOI: 10.33805/2576-8484.149
Sukhendu Mukherjee
This can present a challenge to educators wishing to engage students in the classroom while still providing required content in order to enhance learning outcomes. In Teaching and learning communication skills, we have a lot to choose from the world of technology: TV, CD Rom, Computers, the Internet, Electronic Dictionary, Email, Blogs and Audio Cassettes, Power Point, Videos, DVD’s or VCD’s. The last two decades have witnessed a revolution due to onset of technology, and has changed the dynamics of educational institutes, and has also influenced the educational system and the way people interact and work in the society. This rapid rising and development of information technology has offered a better pattern to explore the new teaching model. Using multimedia to create a context to teach communication skill has its unique advantages. As a result technology plays a very important role in teaching communication skill.
这可能会给希望让学生参与课堂,同时仍提供所需内容以提高学习成果的教育工作者带来挑战。在教学和学习沟通技巧时,我们可以从技术的世界中选择很多:电视、光盘、计算机、互联网、电子词典、电子邮件、博客和录音带、PowerPoint、视频、DVD或VCD。在过去的二十年里,由于技术的出现,发生了一场革命,改变了教育机构的动态,也影响了教育系统以及人们在社会中的互动和工作方式。信息技术的迅速崛起和发展为探索新的教学模式提供了一种更好的模式。运用多媒体创设语境教学交际技巧有其独特的优势。因此,技术在交际技能的教学中起着非常重要的作用。
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引用次数: 9
Asymptomatic Hemangioma of the Duodenum 十二指肠无症状血管瘤
Q4 Multidisciplinary Pub Date : 2018-06-11 DOI: 10.33805/2576-8484.148
T. Thomas, M. Haney, M. Doepker
Hemangiomas of the small bowel are exceedingly rare benign tumors. When diagnosed they are found in the setting of an acute gastrointestinal bleeding, but can also be involved in intussusception, obstruction, and cause pain. There are few reports of this case over all, and incidental or asymptomatic cases are rare for adult patients. Although computed tomography with angiography or tagged red blood cell scans are pivotal for acute active bleeding, endoscopy has become pivotal in diagnosis of lesions that are quiescent. Management is also variable as endoscopy, laparoscopy, and open surgery have all been utilized with success.
小肠血管瘤是极为罕见的良性肿瘤。当被诊断时,它们是在急性胃肠道出血的情况下发现的,但也可能涉及肠套叠、梗阻和引起疼痛。总的来说,这种病例的报告很少,成年患者很少出现偶发或无症状病例。尽管带有血管造影术或标记红细胞扫描的计算机断层扫描对急性活动性出血至关重要,但内窥镜检查已成为诊断静止病变的关键。管理也是可变的,因为内窥镜检查、腹腔镜检查和开放手术都已成功使用。
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引用次数: 0
Managing The Curriculum 课程管理
Q4 Multidisciplinary Pub Date : 2017-02-14 DOI: 10.4135/9781446220610
Salwa, Sri Kamaliasari, T. Sumarni
This paper describes general guidelines for managing curriculum. Managing a curriculum change is a complex problem. There are two frameworks supporting the process. The first is a learning framework centered on how students learn, the second is a conceptual framework enabling the detailed design of learning activities, which implies a change in attitudes towards teaching. The last step is implementing the curriculum. We think that these guidelines may help schools or universities manage their own change process. Construction management education needs a curriculum model that will help school or university to achieve and maintain relevant construction management programs. This paper describes a curriculum model that integrates curriculum development, instructional design, and program evaluation.
本文描述了课程管理的一般准则。管理课程变化是一个复杂的问题。有两个框架支持这个过程。第一种是以学生如何学习为中心的学习框架,第二种是能够详细设计学习活动的概念框架,这意味着对教学态度的改变。最后一步是实施课程。我们认为这些指导方针可以帮助学校或大学管理他们自己的变化过程。建筑管理教育需要一种课程模式来帮助学校或大学实现和维持相关的建筑管理课程。本文描述了一个集课程开发、教学设计和课程评估为一体的课程模式。
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引用次数: 0
Development Incentive Program at Carbon Trading Activity in KPHP Tasik Besar Serkap 发展激励计划在KPHP的碳交易活动Tasik Besar Serkap
Q4 Multidisciplinary Pub Date : 2017-02-14 DOI: 10.31227/osf.io/eh8pn
Emy Sadjati, M. Ikhwan, A. T. Ratnaningsih
REDD+ mechanism has been considered as an effective way to mitigate climate change in developing countries since it targets to remove carbon emissions and compensate the local communities for their conservation efforts. Incentive programs of REDD+ projects should be tailored carefully because they can cause both positive and negative effects to local communities. This research was conducted to suggest incentive program options for a peat land REDD+ project in Riau Provincial. Frequently adopted incentive programs were identified from literature review, and few more options were added based on previous local survey. Seven incentive options were finalized for the survey through discussion with KPH Tasik Besar Serkap. To figure out preference on and importance of the incentive options for local communities, questionnaire survey was conducted on 40 respondent in 2 villages around the project area. Local livelihoods activities in forest were also investigated. Collected data was used for frequency analysis and AHP analysis. Although gap between preference and importance of the options was found, the difference was minor. Among the incentive options, the respondents preferred provision of ‘goods for agriculture and fishery’, ‘electricity generator’, ‘establishment of community forest’ and ‘job creation’. Diverse local livelihood activities in forests were confirmed, though intensity of dependence was different among the villages. It is concluded that a set of small incentive programs would lead to better results than ‘one-big’ incentive program, since it can provide more opportunities for local people to participate in. To develop an effective incentive program for REDD+ project, local preference, importance for local community, and impacts on local livelihood should be considered simultaneously.
REDD+机制被认为是减缓发展中国家气候变化的有效途径,因为它旨在消除碳排放并补偿当地社区的保护努力。REDD+项目的激励方案应谨慎制定,因为它们可能对当地社区产生积极和消极的影响。本研究旨在为廖内省泥炭地REDD+项目提供激励方案。从文献综述中确定了常用的激励方案,并根据之前的地方调查增加了一些选项。通过与KPH Tasik Besar Serkap讨论,最终确定了调查的七个奖励方案。为了了解当地社区对激励方案的偏好和重要性,我们在项目区周围的2个村庄对40名受访者进行了问卷调查。还对当地森林生计活动进行了调查。收集的数据用于频率分析和AHP分析。虽然选择的偏好和重要性之间存在差距,但差异很小。在奖励方案中,被调查者倾向于提供“农业和渔业产品”、“发电机”、“建立社区森林”和“创造就业机会”。虽然各个村庄对森林的依赖程度不同,但证实了当地森林生计活动的多样性。结论是,一套小的激励方案比“一个大”的激励方案效果更好,因为它可以为当地人提供更多的参与机会。要制定有效的REDD+项目激励方案,需要同时考虑当地偏好、对当地社区的重要性以及对当地生计的影响。
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引用次数: 0
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Edelweiss Applied Science and Technology
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