Pub Date : 2022-04-06DOI: 10.1007/s41666-022-00115-0
João Luis Zeni Montenegro, C. A. da Costa
{"title":"The HoPE Model Architecture: a Novel Approach to Pregnancy Information Retrieval Based on Conversational Agents","authors":"João Luis Zeni Montenegro, C. A. da Costa","doi":"10.1007/s41666-022-00115-0","DOIUrl":"https://doi.org/10.1007/s41666-022-00115-0","url":null,"abstract":"","PeriodicalId":36444,"journal":{"name":"Journal of Healthcare Informatics Research","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2022-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43365973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-13DOI: 10.1007/s41666-022-00116-z
Md. Ahsanul Kabir, Aljohara Almulhim, Xiao Luo, M. Hasan
{"title":"Informative Causality Extraction from Medical Literature via Dependency-Tree–Based Patterns","authors":"Md. Ahsanul Kabir, Aljohara Almulhim, Xiao Luo, M. Hasan","doi":"10.1007/s41666-022-00116-z","DOIUrl":"https://doi.org/10.1007/s41666-022-00116-z","url":null,"abstract":"","PeriodicalId":36444,"journal":{"name":"Journal of Healthcare Informatics Research","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2022-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45607732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-01DOI: 10.1007/s41666-021-00107-6
Qian He, Emmanuel O Agu
Sedentary behaviors are now prevalent as most modern jobs are done while seated. However, such sedentary behaviors have been found to increase the risk of several ailments including diabetes, cardiovascular disease, and all-cause mortality. Current interventions are mostly reactive and are triggered after the user has already been sedentary. Behavior change theory suggests that preventive sedentary interventions, which are triggered before a person becomes sedentary, are more likely to succeed. In this paper, we characterize user patterns of sedentary behaviors by analyzing smartphone-sensor data in a real-world dataset. Our work reveals location types (where), times of day/week (when), and smartphone contexts in which sedentary behaviors are most likely. Leveraging our findings, we then propose a set of context-aware probabilistic models that can predict sedentary behaviors in advance by analyzing smartphone sensor data. Our Context-Aware Predictive (CAP) models leverage smartphone-sensed contextual variables and the user's history of sedentary behaviors to predict their future sedentary behaviors. We rigorously analyze the performance of our models and discuss the implications of our work.
{"title":"Context-Aware Probabilistic Models for Predicting Future Sedentary Behaviors of Smartphone Users.","authors":"Qian He, Emmanuel O Agu","doi":"10.1007/s41666-021-00107-6","DOIUrl":"https://doi.org/10.1007/s41666-021-00107-6","url":null,"abstract":"<p><p>Sedentary behaviors are now prevalent as most modern jobs are done while seated. However, such sedentary behaviors have been found to increase the risk of several ailments including diabetes, cardiovascular disease, and all-cause mortality. Current interventions are mostly reactive and are triggered after the user has already been sedentary. Behavior change theory suggests that preventive sedentary interventions, which are triggered before a person becomes sedentary, are more likely to succeed. In this paper, we characterize user patterns of sedentary behaviors by analyzing smartphone-sensor data in a real-world dataset. Our work reveals location types (where), times of day/week (when), and smartphone contexts in which sedentary behaviors are most likely. Leveraging our findings, we then propose a set of context-aware probabilistic models that can predict sedentary behaviors in advance by analyzing smartphone sensor data. Our Context-Aware Predictive (CAP) models leverage smartphone-sensed <i>contextual variables</i> and the user's history of <i>sedentary behaviors</i> to predict their future sedentary behaviors. We rigorously analyze the performance of our models and discuss the implications of our work.</p>","PeriodicalId":36444,"journal":{"name":"Journal of Healthcare Informatics Research","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8982751/pdf/41666_2021_Article_107.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9359045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-01DOI: 10.1007/s41666-021-00109-4
Sayan Das, Jaya Sil
People of rural India often suffer from acute health conditions like diarrhea, flu, lung congestion, and anemia, but they are not receiving treatment even at primary level due to scarcity of doctors and health infrastructure in remote villages. Health workers are involved in diagnosing the patients based on the symptoms and physiological signs. However, due to inadequate domain knowledge, lack of expertise, and error in measuring the health data, uncertainty creeps in the decision space, resulting many false cases in predicting the diseases. The paper proposes an uncertainty management technique using fuzzy and rough set theory to diagnose the patients with minimum false-positive and false-negative cases. We use fuzzy variables with proper semantic to represent the vagueness of input data, appearing due to measurement error. We derive initial degree of belonging of each patient in two different disease class labels (YES/NO) using the fuzzified input data. Next, we apply rough set theory to manage uncertainty in diagnosing the diseases by learning approximations of the decision boundary between the two class labels. The optimum lower and upper approximation membership functions for each disease class label have been obtained using Non-dominated Sorting Genetic Algorithm-II (NSGA-II). Finally, using the proposed disease_similarity_factor, new patients are diagnosed precisely with 98% accuracy and minimum false cases.
印度农村的人经常患有腹泻、流感、肺充血和贫血等急性疾病,但由于偏远村庄医生和卫生基础设施匮乏,他们甚至没有得到初级治疗。卫生工作者根据症状和生理体征参与对患者的诊断。然而,由于领域知识不足,缺乏专业知识,以及在测量健康数据时存在错误,不确定性在决策空间中蔓延,导致许多疾病预测的错误案例。本文提出了一种利用模糊和粗糙集理论的不确定性管理技术来诊断假阳性和假阴性病例最少的患者。我们使用具有适当语义的模糊变量来表示由于测量误差而出现的输入数据的模糊性。我们使用模糊化的输入数据导出每个患者在两种不同疾病类别标签(YES/NO)中的初始归属程度。接下来,我们应用粗糙集理论通过学习两个类标签之间的决策边界的近似来管理疾病诊断中的不确定性。利用非支配排序遗传算法- ii (NSGA-II)获得了每个疾病分类标签的最优上下近似隶属度函数。最后,利用提出的疾病相似度因子,新患者的诊断准确率达到98%,假病例最少。
{"title":"Managing Boundary Uncertainty in Diagnosing the Patients of Rural Area Using Fuzzy and Rough Set.","authors":"Sayan Das, Jaya Sil","doi":"10.1007/s41666-021-00109-4","DOIUrl":"https://doi.org/10.1007/s41666-021-00109-4","url":null,"abstract":"<p><p>People of rural India often suffer from acute health conditions like diarrhea, flu, lung congestion, and anemia, but they are not receiving treatment even at primary level due to scarcity of doctors and health infrastructure in remote villages. Health workers are involved in diagnosing the patients based on the symptoms and physiological signs. However, due to inadequate domain knowledge, lack of expertise, and error in measuring the health data, uncertainty creeps in the decision space, resulting many false cases in predicting the diseases. The paper proposes an uncertainty management technique using fuzzy and rough set theory to diagnose the patients with minimum false-positive and false-negative cases. We use fuzzy variables with proper semantic to represent the vagueness of input data, appearing due to measurement error. We derive initial degree of belonging of each patient in two different disease class labels (YES/NO) using the fuzzified input data. Next, we apply rough set theory to manage uncertainty in diagnosing the diseases by learning approximations of the decision boundary between the two class labels. The optimum lower and upper approximation membership functions for each disease class label have been obtained using Non-dominated Sorting Genetic Algorithm-II (NSGA-II). Finally, using the proposed <i>disease_similarity_factor</i>, new patients are diagnosed precisely with 98% accuracy and minimum false cases.</p>","PeriodicalId":36444,"journal":{"name":"Journal of Healthcare Informatics Research","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8982726/pdf/41666_2021_Article_109.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9359042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The COVID-19 pandemic has affected people's lives in many ways. Social media data can reveal public perceptions and experience with respect to the pandemic, and also reveal factors that hamper or support efforts to curb global spread of the disease. In this paper, we analyzed COVID-19-related comments collected from six social media platforms using natural language processing (NLP) techniques. We identified relevant opinionated keyphrases and their respective sentiment polarity (negative or positive) from over 1 million randomly selected comments, and then categorized them into broader themes using thematic analysis. Our results uncover 34 negative themes out of which 17 are economic, socio-political, educational, and political issues. Twenty (20) positive themes were also identified. We discuss the negative issues and suggest interventions to tackle them based on the positive themes and research evidence.
{"title":"COVID-19 Pandemic: Identifying Key Issues Using Social Media and Natural Language Processing.","authors":"Oladapo Oyebode, Chinenye Ndulue, Dinesh Mulchandani, Banuchitra Suruliraj, Ashfaq Adib, Fidelia Anulika Orji, Evangelos Milios, Stan Matwin, Rita Orji","doi":"10.1007/s41666-021-00111-w","DOIUrl":"10.1007/s41666-021-00111-w","url":null,"abstract":"<p><p>The COVID-19 pandemic has affected people's lives in many ways. Social media data can reveal public perceptions and experience with respect to the pandemic, and also reveal factors that hamper or support efforts to curb global spread of the disease. In this paper, we analyzed COVID-19-related comments collected from six social media platforms using natural language processing (NLP) techniques. We identified relevant opinionated keyphrases and their respective sentiment polarity (negative or positive) from over 1 million randomly selected comments, and then categorized them into broader themes using thematic analysis. Our results uncover 34 negative themes out of which 17 are economic, socio-political, educational, and political issues. Twenty (20) positive themes were also identified. We discuss the negative issues and suggest interventions to tackle them based on the positive themes and research evidence.</p>","PeriodicalId":36444,"journal":{"name":"Journal of Healthcare Informatics Research","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2022-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8853170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39807504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-11eCollection Date: 2022-06-01DOI: 10.1007/s41666-022-00114-1
Christopher C Yang
The principle behind artificial intelligence is mimicking human intelligence in the way that it can perform tasks, recognize patterns, or predict outcomes through learning from the acquired data of various sources. Artificial intelligence and machine learning algorithms have been widely used in autonomous driving, recommender systems in electronic commerce and social media, fintech, natural language understanding, and question answering systems. Artificial intelligence is also gradually changing the landscape of healthcare research (Yu et al. in Biomed Eng 2:719-731, 25). The rule-based approach that relied on the curation of medical knowledge and the construction of robust decision rules had drawn significant attention in diagnosing diseases and clinical decision support since half a century ago. In recent years, machine learning algorithms such as deep learning that can account for complex interactions between features is shown to be promising in predictive modeling in healthcare (Deo in Circulation 132:1920-1930, 26). Although many of these artificial intelligence and machine learning algorithms can achieve remarkably high performance, it is often difficult to be completely adopted in practical clinical environments due to the lack of explainability in some of these algorithms. Explainable artificial intelligence (XAI) is emerging to assist in the communication of internal decisions, behavior, and actions to health care professionals. Through explaining the prediction outcomes, XAI gains the trust of the clinicians as they may learn how to apply the predictive modeling in practical situations instead of blindly following the predictions. There are still many scenarios to explore how to make XAI effective in clinical settings due to the complexity of medical knowledge.
人工智能背后的原理是模仿人类智能,通过从各种来源获得的数据中学习来执行任务、识别模式或预测结果。人工智能和机器学习算法已广泛应用于自动驾驶、电子商务和社交媒体的推荐系统、金融科技、自然语言理解和问答系统。人工智能也在逐渐改变医疗保健研究的格局(Yu et al. in Biomed Eng 2:719-731, 25)。半个世纪以来,基于规则的方法依赖于医学知识的管理和健全决策规则的构建,在疾病诊断和临床决策支持方面引起了极大的关注。近年来,机器学习算法,如深度学习,可以解释特征之间复杂的相互作用,在医疗保健的预测建模中被证明是有前途的(Deo In Circulation 132:1920-1930, 26)。尽管这些人工智能和机器学习算法中有许多可以实现非常高的性能,但由于其中一些算法缺乏可解释性,通常难以在实际临床环境中完全采用。可解释的人工智能(XAI)正在兴起,以协助与医疗保健专业人员进行内部决策、行为和行动的沟通。通过对预测结果的解释,XAI获得了临床医生的信任,因为他们可以学习如何将预测模型应用于实际情况,而不是盲目地遵循预测。由于医学知识的复杂性,如何使XAI在临床环境中发挥作用仍有许多场景需要探索。
{"title":"Explainable Artificial Intelligence for Predictive Modeling in Healthcare.","authors":"Christopher C Yang","doi":"10.1007/s41666-022-00114-1","DOIUrl":"https://doi.org/10.1007/s41666-022-00114-1","url":null,"abstract":"<p><p>The principle behind artificial intelligence is mimicking human intelligence in the way that it can perform tasks, recognize patterns, or predict outcomes through learning from the acquired data of various sources. Artificial intelligence and machine learning algorithms have been widely used in autonomous driving, recommender systems in electronic commerce and social media, fintech, natural language understanding, and question answering systems. Artificial intelligence is also gradually changing the landscape of healthcare research (Yu et al. in Biomed Eng 2:719-731, 25). The rule-based approach that relied on the curation of medical knowledge and the construction of robust decision rules had drawn significant attention in diagnosing diseases and clinical decision support since half a century ago. In recent years, machine learning algorithms such as deep learning that can account for complex interactions between features is shown to be promising in predictive modeling in healthcare (Deo in Circulation 132:1920-1930, 26). Although many of these artificial intelligence and machine learning algorithms can achieve remarkably high performance, it is often difficult to be completely adopted in practical clinical environments due to the lack of explainability in some of these algorithms. Explainable artificial intelligence (XAI) is emerging to assist in the communication of internal decisions, behavior, and actions to health care professionals. Through explaining the prediction outcomes, XAI gains the trust of the clinicians as they may learn how to apply the predictive modeling in practical situations instead of blindly following the predictions. There are still many scenarios to explore how to make XAI effective in clinical settings due to the complexity of medical knowledge.</p>","PeriodicalId":36444,"journal":{"name":"Journal of Healthcare Informatics Research","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2022-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39945547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-19eCollection Date: 2022-06-01DOI: 10.1007/s41666-021-00112-9
Ryan Admiraal, Jules Millen, Ankit Patel, Tim Chambers
We present results from a 7-day trial of a Bluetooth-enabled card by the New Zealand Ministry of Health to investigate its usefulness in contact tracing. A comparison of the card with traditional contact tracing, which relies on self-reports of contacts to case investigators, demonstrated significantly higher levels of internal consistency in detected contact events by Bluetooth-enabled cards with 88% of contact events being detected by both cards involved in an interaction as compared to 64% for self-reports of contacts to case investigators. We found no clear evidence of memory recall worsening in reporting contact events that were further removed in time from the date of a case investigation. Roughly 66% of contact events between trial participants that were indicated by cards went unreported to case investigators, simultaneously highlighting the shortcomings of traditional contact tracing and the value of Bluetooth technology in detecting contact events that may otherwise go unreported. At the same time, cards detected only 65% of self-reported contact events, in part due to increasing non-compliance as the study progressed. This would suggest that Bluetooth technology can only be considered as a supplemental tool in contact tracing and not a viable replacement to traditional contact tracing unless measures are introduced to ensure greater compliance.
{"title":"A Case Study of Bluetooth Technology as a Supplemental Tool in Contact Tracing.","authors":"Ryan Admiraal, Jules Millen, Ankit Patel, Tim Chambers","doi":"10.1007/s41666-021-00112-9","DOIUrl":"https://doi.org/10.1007/s41666-021-00112-9","url":null,"abstract":"<p><p>We present results from a 7-day trial of a Bluetooth-enabled card by the New Zealand Ministry of Health to investigate its usefulness in contact tracing. A comparison of the card with traditional contact tracing, which relies on self-reports of contacts to case investigators, demonstrated significantly higher levels of internal consistency in detected contact events by Bluetooth-enabled cards with 88% of contact events being detected by both cards involved in an interaction as compared to 64% for self-reports of contacts to case investigators. We found no clear evidence of memory recall worsening in reporting contact events that were further removed in time from the date of a case investigation. Roughly 66% of contact events between trial participants that were indicated by cards went unreported to case investigators, simultaneously highlighting the shortcomings of traditional contact tracing and the value of Bluetooth technology in detecting contact events that may otherwise go unreported. At the same time, cards detected only 65% of self-reported contact events, in part due to increasing non-compliance as the study progressed. This would suggest that Bluetooth technology can only be considered as a supplemental tool in contact tracing and not a viable replacement to traditional contact tracing unless measures are introduced to ensure greater compliance.</p>","PeriodicalId":36444,"journal":{"name":"Journal of Healthcare Informatics Research","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2022-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39860876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01Epub Date: 2021-12-07DOI: 10.1007/s41666-021-00110-x
Fernando A Inthamoussou, Fernando Valenciaga, Sebastián Núñez, Fabricio Garelli
This work presents an extended and age-band compartmentalised SEIR model that allows describing the spread evolution of SARS-CoV-2 and evaluating the effect of different detection rates, vaccination strategies or immunity periods. The model splits up the population into fifteen age groups of 5 years each, linked through a statistical interaction matrix that includes seventeen health states within each age group. An age-dependent transmission rate takes into account infectious between the groups as well the effect of interventions such as quarantines and mobility restrictions. Further, the proposal includes a nonlinear switched controller for model tuning purposes guarantying a simple and fast adjusting process. To illustrate the model potentials, the particular case of COVID-19 evolution in Argentina is analysed by simulation of three scenarios: (i) different detection levels combined with mobility restrictions, (ii) vaccination campaigns with re-opening of activities and (iii) vaccination campaigns with possible reinfections. The results exhibit how the model can aid the authorities in the decision making process.
{"title":"Extended SEIR Model for Health Policies Assessment Against the COVID-19 Pandemic: the Case of Argentina.","authors":"Fernando A Inthamoussou, Fernando Valenciaga, Sebastián Núñez, Fabricio Garelli","doi":"10.1007/s41666-021-00110-x","DOIUrl":"https://doi.org/10.1007/s41666-021-00110-x","url":null,"abstract":"<p><p>This work presents an extended and age-band compartmentalised SEIR model that allows describing the spread evolution of SARS-CoV-2 and evaluating the effect of different detection rates, vaccination strategies or immunity periods. The model splits up the population into fifteen age groups of 5 years each, linked through a statistical interaction matrix that includes seventeen health states within each age group. An age-dependent transmission rate takes into account infectious between the groups as well the effect of interventions such as quarantines and mobility restrictions. Further, the proposal includes a nonlinear switched controller for model tuning purposes guarantying a simple and fast adjusting process. To illustrate the model potentials, the particular case of COVID-19 evolution in Argentina is analysed by simulation of three scenarios: (i) different detection levels combined with mobility restrictions, (ii) vaccination campaigns with re-opening of activities and (iii) vaccination campaigns with possible reinfections. The results exhibit how the model can aid the authorities in the decision making process.</p>","PeriodicalId":36444,"journal":{"name":"Journal of Healthcare Informatics Research","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8650742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39583140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01Epub Date: 2021-09-15DOI: 10.1007/s41666-021-00106-7
Md Shahnoor Amin, Marcin Wozniak, Lidija Barbaric, Shanel Pickard, Rahul S Yerrabelli, Anton Christensen, Olivia C Coiado
The COVID-19 pandemic has impacted the whole world and raised concerns about its effects on different human organ systems. Early detection of COVID-19 may significantly increase the rate of survival; thus, it is critical that the disease is detected early. Emerging technologies have been used to prevent, diagnose, and manage COVID-19 among the populace in the USA and globally. Numerous studies have revealed the growing implementation of novel engineered systems during the intervention at various points of the disease's pathogenesis, especially as it relates to comorbidities and complications related to cardiovascular and respiratory organ systems. In this review, we provide a succinct, but extensive, review of the pathogenesis of COVID-19, particularly as it relates to angiotensin-converting enzyme 2 (ACE2) as a viral entry point. This is followed by a comprehensive analysis of cardiovascular and respiratory comorbidities of COVID-19 and novel technologies that are used to diagnose and manage hospitalized patients. Continuous cardiorespiratory monitoring systems, novel machine learning algorithms for rapidly triaging patients, various imaging modalities, wearable immunosensors, hotspot tracking systems, and other emerging technologies are reviewed. COVID-19 effects on the immune system, associated inflammatory biomarkers, and innovative therapies are also assessed. Finally, with emphasis on the impact of wearable and non-wearable systems, this review highlights future technologies that could help diagnose, monitor, and mitigate disease progression. Technologies that account for an individual's health conditions, comorbidities, and even socioeconomic factors can drastically reduce the high mortality seen among many COVID-19 patients, primarily via disease prevention, early detection, and pertinent management.
{"title":"Experimental Technologies in the Diagnosis and Treatment of COVID-19 in Patients with Comorbidities.","authors":"Md Shahnoor Amin, Marcin Wozniak, Lidija Barbaric, Shanel Pickard, Rahul S Yerrabelli, Anton Christensen, Olivia C Coiado","doi":"10.1007/s41666-021-00106-7","DOIUrl":"https://doi.org/10.1007/s41666-021-00106-7","url":null,"abstract":"<p><p>The COVID-19 pandemic has impacted the whole world and raised concerns about its effects on different human organ systems. Early detection of COVID-19 may significantly increase the rate of survival; thus, it is critical that the disease is detected early. Emerging technologies have been used to prevent, diagnose, and manage COVID-19 among the populace in the USA and globally. Numerous studies have revealed the growing implementation of novel engineered systems during the intervention at various points of the disease's pathogenesis, especially as it relates to comorbidities and complications related to cardiovascular and respiratory organ systems. In this review, we provide a succinct, but extensive, review of the pathogenesis of COVID-19, particularly as it relates to angiotensin-converting enzyme 2 (ACE2) as a viral entry point. This is followed by a comprehensive analysis of cardiovascular and respiratory comorbidities of COVID-19 and novel technologies that are used to diagnose and manage hospitalized patients. Continuous cardiorespiratory monitoring systems, novel machine learning algorithms for rapidly triaging patients, various imaging modalities, wearable immunosensors, hotspot tracking systems, and other emerging technologies are reviewed. COVID-19 effects on the immune system, associated inflammatory biomarkers, and innovative therapies are also assessed. Finally, with emphasis on the impact of wearable and non-wearable systems, this review highlights future technologies that could help diagnose, monitor, and mitigate disease progression. Technologies that account for an individual's health conditions, comorbidities, and even socioeconomic factors can drastically reduce the high mortality seen among many COVID-19 patients, primarily via disease prevention, early detection, and pertinent management.</p>","PeriodicalId":36444,"journal":{"name":"Journal of Healthcare Informatics Research","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39431642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01Epub Date: 2021-09-16DOI: 10.1007/s41666-021-00105-8
Omar Sharif, Md Rafiqul Islam, Md Zobaer Hasan, Muhammad Ashad Kabir, Md Emran Hasan, Salman A AlQahtani, Guandong Xu
The aim of this study is to analyse the coronavirus disease 2019 (COVID-19) outbreak in Bangladesh. This study investigates the impact of demographic variables on the spread of COVID-19 as well as tries to forecast the COVID-19 infected numbers. First of all, this study uses Fisher's Exact test to investigate the association between the infected groups of COVID-19 and demographical variables. Second, it exploits the ANOVA test to examine significant difference in the mean infected number of COVID-19 cases across the population density, literacy rate, and regions/divisions in Bangladesh. Third, this research predicts the number of infected cases in the epidemic peak region of Bangladesh for the year 2021. As a result, from the Fisher's Exact test, we find a very strong significant association between the population density groups and infected groups of COVID-19. And, from the ANOVA test, we observe a significant difference in the mean infected number of COVID-19 cases across the five different population density groups. Besides, the prediction model shows that the cumulative number of infected cases would be raised to around 500,000 in the most densely region of Bangladesh, Dhaka division.
{"title":"Analyzing the Impact of Demographic Variables on Spreading and Forecasting COVID-19.","authors":"Omar Sharif, Md Rafiqul Islam, Md Zobaer Hasan, Muhammad Ashad Kabir, Md Emran Hasan, Salman A AlQahtani, Guandong Xu","doi":"10.1007/s41666-021-00105-8","DOIUrl":"https://doi.org/10.1007/s41666-021-00105-8","url":null,"abstract":"<p><p>The aim of this study is to analyse the coronavirus disease 2019 (COVID-19) outbreak in Bangladesh. This study investigates the impact of demographic variables on the spread of COVID-19 as well as tries to forecast the COVID-19 infected numbers. First of all, this study uses Fisher's Exact test to investigate the association between the infected groups of COVID-19 and demographical variables. Second, it exploits the ANOVA test to examine significant difference in the mean infected number of COVID-19 cases across the population density, literacy rate, and regions/divisions in Bangladesh. Third, this research predicts the number of infected cases in the epidemic peak region of Bangladesh for the year 2021. As a result, from the Fisher's Exact test, we find a very strong significant association between the population density groups and infected groups of COVID-19. And, from the ANOVA test, we observe a significant difference in the mean infected number of COVID-19 cases across the five different population density groups. Besides, the prediction model shows that the cumulative number of infected cases would be raised to around 500,000 in the most densely region of Bangladesh, Dhaka division.</p>","PeriodicalId":36444,"journal":{"name":"Journal of Healthcare Informatics Research","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8444526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39436865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}