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Chronic thromboembolic pulmonary hypertension 慢性血栓栓塞性肺动脉高压
Q3 Medicine Pub Date : 2023-03-01 DOI: 10.5554/22562087.e1060
Ryan Kaplevatsky, Jovana Hanna, S. Khanna
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引用次数: 0
Surgical care and trauma patients capacity in Piura, Perú - Cross-sectional study. Perú的外科护理和创伤患者能力——横断面研究
Q3 Medicine Pub Date : 2023-02-02 Epub Date: 2022-12-15 DOI: 10.5554/22562087.e1058
Roxanna M Garcia, Carlos Javier Shiraishi-Zapata, Ricardo César Zúñiga Vallejos, Dante Pool Gil Chiroque, Mario Alejandro Oyanguren Maldonado, Juan Carlos Paico Palacios, Ebella Estela Romero, Aldo Humberto Villarreal Álamo, Jaime Sergio Castillo Tovar, Salomón Jesús Aguirre Uribe, Renato Díaz Ruiz, Yovanky Miluska More Vilela

Introduction: Low and medium income countries face challenges in access and delivery of surgical care, resulting in a high number of deaths and disabled individuals.

Objective: To estimate the capacity to provide surgical and trauma care in public hospitals in the Piura region, Perú, a middle income country.

Methods: A survey was administered in public hospitals in the Peruvian region of Piura, which combined the Spanish versions of the PIPES and INTACT surveys, and the WHO situational analysis tool. The extent of the event was assessed based in the absolute differences between the medians of the scores estimated, and the Mann-Whitney bilateral tests, according to the geographical location and the level of hospital complexity.

Results: Seven public hospitals that perform surgeries in the Piura region were assessed. Three provinces (3/8) did not have any complexity healthcare institutions. The average hospital in the peripheral provinces tended to be smaller than in the capital province in INTACT (8.25 vs. 9.5, p = 0.04). Additionally, water supply issues were identified (2/7), lack of incinerator (3/7), lack of uninterrupted availability of a CT-scanner (5/7) and problems with working hours; in other words, the blood banks in two hospitals were not open 24 hours.

Conclusions: There is a significant inequality among the provinces in the region in terms of their trauma care capacities and several shortfalls in the public sector healthcare infrastructure. This information is required to conduct future research on capacity measurements in every public and private institution in the Peruvian region of Piura.

引言:中低收入国家在获得和提供外科护理方面面临挑战,导致大量死亡和残疾人。目的:评估中等收入国家秘鲁皮乌拉地区公立医院提供外科和创伤患者护理的能力。方法:在秘鲁皮乌拉地区的公立医院进行一项调查,该调查结合了西班牙版的PIPES和INTACT调查以及世界卫生组织情况分析工具。根据地理位置和医院复杂程度,根据估计得分的中位数与Mann-Whitney双边测试之间的绝对差异来评估事件的程度。结果:对皮乌拉地区七家进行手术的公立医院进行了评估。三个省(3/8)没有任何复杂的医疗机构。INTACT中,外围省份的平均医院往往比首都省份小(8.25比9.5,p=0.04)。此外,还发现了供水问题(2/7)、缺乏焚烧炉(3/7)、CT扫描仪不间断可用(5/7)和血库工作时间(2/7;换句话说,两家医院的血库没有24小时开放。结论:该地区各省在创伤护理能力和公共部门医疗基础设施方面存在严重不平等。这些信息是未来对秘鲁每个公共和私营机构的能力测量进行研究所必需的。
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引用次数: 0
Escobar syndrome, difficult airway management in pediatrics: A case report Escobar综合征,儿科气道管理困难1例报告
Q3 Medicine Pub Date : 2022-12-15 DOI: 10.5554/22562087.e1057
Angelina Lippi Quiñones, Nathalie López Jaque, Verónica Maureira Moreno
Escobar syndrome is a rare, autosomal recessive disease of unknown incidence. It is characterized by multiple skeletal, genitourinary and orofacial abnormalities. The multiple malformations (mainly orofacial) and restricted mobility of these patients pose a challenge to the anesthesia team, especially as regards airway management. We describe the clinical case of a pediatric patient diagnosed with Escobar syndrome who underwent two consecutive anesthesia interventions, with evidence of progressive airway anomalies that characterize this syndrome.  The case required adaptation, according to the clinical stage of the disease, of the current algorithms used to approach an anticipated difficult airway in pediatrics,  and  the incorporation of new devices, not described so far in patients with this pathology, as part of the planning and execution phases.
埃斯科瓦尔综合征是一种罕见的常染色体隐性遗传病,发病率不详。它的特点是多发性骨骼,泌尿生殖系统和口面部异常。这些患者的多重畸形(主要是口面部)和活动受限给麻醉团队带来了挑战,特别是在气道管理方面。我们描述了一个临床病例的儿科患者诊断为埃斯科瓦尔综合征谁接受了连续两次麻醉干预,有证据表明进行性气道异常,表征该综合征。根据疾病的临床阶段,该病例需要适应当前用于处理预期的儿科气道困难的算法,并结合新设备,作为计划和执行阶段的一部分,目前尚未在患有这种病理的患者中描述。
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引用次数: 0
Premedication with midazolam in low-risk surgery in children does not reduce the incidence of postoperative delirium. Cohort study 儿童低风险手术前应用咪达唑仑不能降低术后谵妄的发生率。队列研究
Q3 Medicine Pub Date : 2022-10-27 DOI: 10.5554/22562087.e1055
V. H. González Cárdenas, Daniel Santiago Benítez Ávila, Wilson Javier Gómez Barajas, Mario Alexander Tamayo Reina, Igor Leonardo Pinzón Villazón, José Luis Cuervo Pulgarín, William Sneyder Díaz Díaz, Ivonne Alejandra Martínez
Introduction: Pediatric postoperative delirium is a frequent complication for which preventive pharmacological measures have been suggested.  The use of midazolam as a prophylactic strategy has not yet been thoroughly assessed. Notwithstanding the fact that it is used in pediatric presurgical separation anxiety, its role in delirium is yet to be established.  Objective: To quantify the incidence of pediatric postoperative delirium in patients undergoing low risk surgical interventions, exposed to oral midazolam-based premedication and to explore the protective and risk factors associated with the development of delirium.   Materials and methods: Prospective, analytical observational study with a cohort design. Children were conveniently selected in accordance with the daily list  of surgical procedures in the operating rooms.   The inclusion criteria were children between 2 and 10 years old, ASA I-II, undergoing low risk surgeries. Concurrent and longitudinal follow-up was then conducted upon admission to the post-anesthesia care unit (PACU) for the first hour. Results: A total of 518 children were included. The overall incidence of delirium was 14.4 % (95 % CI: 11.4 %-17.5 %). In the subgroup exposed to midazolam, 178 children were analyzed, with an incidence of delirium of 16.2% (95% CI of 10,8 %-21,7).  These patients exhibited a higher tendency to delirium with the use of sevoflurane or fentanyl, and/or when presenting with severe postoperative pain. Patients exposed to propofol and/or remifentanil showed lower incidences. Conclusions: No reduction in the incidence of emergency pediatric delirium associated with the use of pre-surgical oral midazolam in low risk surgical procedures. Prospective controlled trials and additional research are required to study the effectiveness and safety of this intervention.
引言:小儿术后谵妄是一种常见的并发症,建议采取预防性药物措施。咪达唑仑作为一种预防策略的使用尚未得到彻底评估。尽管它被用于儿科术前分离焦虑症,但它在谵妄中的作用尚待确定。目的:量化接受低风险手术干预的儿童术后谵妄的发生率,并探讨与谵妄发展相关的保护性和危险因素。材料和方法:前瞻性、分析性、观察性研究,采用队列设计。根据手术室每天的手术程序清单,可以方便地选择儿童。纳入标准为2至10岁的儿童,ASA I-II,接受低风险手术。然后在进入麻醉后护理单元(PACU)的第一个小时进行并行和纵向随访。结果:共纳入518名儿童。谵妄的总发生率为14.4%(95%可信区间:11.4%-17.5%)。在暴露于咪达唑仑的亚组中,分析了178名儿童,谵妄的发生率为16.2%(95%置信区间:10,8%-21,7)。这些患者在使用七氟醚或芬太尼和/或出现严重术后疼痛时,表现出更高的谵妄倾向。暴露于丙泊酚和/或瑞芬太尼的患者发生率较低。结论:在低风险外科手术中,术前口服咪达唑仑不会降低儿童急性谵妄的发生率。需要前瞻性对照试验和额外研究来研究这种干预的有效性和安全性。
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引用次数: 0
Why is Madelung’s disease a challenge for the anaesthesiologist? 为什么马德隆氏病对麻醉师来说是一个挑战?
Q3 Medicine Pub Date : 2022-09-16 DOI: 10.5554/22562087.e1051
M. Gregorio, A. Mafra, J. Fonseca, Elisabete Valente
Source: Authors. The accompanying images exhibit a large round, subcutaneous fat mass protruding from the posterior cervical area and also several other masses along the back, in a patient with Madelung disease (Image 1). From an anterior view, it is also possible to see big bulky cheeks and another fat mass on the anterior neck (Image 2). Madelung’s disease, also known as multiple symmetric lipomatosis or Launois–Bensaude syndrome is a rare lipid metabolic disorder characterized by diffuse, progressive growth of encapsulated subcutaneous adipose tissue, in the neck, shoulder and other areas, as can be seen in the image. The exact cause of Madelung’s disease has not yet been fully understood, but there’s one theory that argues that a defect in the adrenergic-stimulated fat breakdown (lipolysis) process could result in improper fat deposits. Madelung’s disease affects more males than females (ratio of 15-30:1) and is usually diagnose between 30-70 years of age. For unclear reasons, this disorder appears to be more prevalent in Mediterranean and European population as compared to others regions in the world. (1) As described, the characteristics of Madelung’s disease imposes a careful anaesthetic approach because it makes
来源:作者。随附的图像显示,一名马德隆病患者的颈部后部有一个巨大的圆形皮下脂肪团,背部也有其他几个脂肪团(图1)。从正面看,也可以看到粗大的脸颊和颈部前部的另一个脂肪团(图2)。马德隆病,也称为多发性对称性脂肪增多症或Launois–Bensaude综合征,是一种罕见的脂质代谢紊乱,其特征是颈部、肩部和其他区域的皮下脂肪组织弥漫性、进行性生长。马德隆病的确切病因尚未完全清楚,但有一种理论认为,肾上腺素能刺激的脂肪分解(脂解)过程中的缺陷可能会导致不适当的脂肪沉积。马德隆氏病影响的男性多于女性(比例为15-30:1),通常在30-70岁之间诊断。由于不清楚的原因,与世界上其他地区相比,这种疾病似乎在地中海和欧洲人口中更为普遍。(1) 如前所述,马德隆病的特点要求采取谨慎的麻醉方法,因为它会
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引用次数: 0
Anterolateral papillary muscle rupture in acute myocardial infarction 急性心肌梗死的前外侧乳头肌破裂
Q3 Medicine Pub Date : 2022-09-16 DOI: 10.5554/22562087.e1052
S. Khanna, R. Richardson, Carlos Trombetta, Roshni Sreedharan
a Department of Cardiothoracic Anesthesiology, Anesthesiology Institute, Cleveland Clinic Foundation. Cleveland, USA. b Department of General Anesthesiology, Anesthesiology Institute, Cleveland Clinic Foundation. Cleveland, USA. c Department of Outcomes Research, Anesthesiology Institute, Cleveland Clinic Foundation. Cleveland, USA. d Department of Intensive Care and Resuscitation, Anesthesiology Institute, Cleveland Clinic Foundation. Cleveland, USA. Correspondence: Department of Cardiothoracic Anesthesiology, Department of General Anesthesiology and Department of Outcomes Research, Anesthesiology Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, E3-108, Cleveland Clinic Foundation, Cleveland, Ohio 44122, USA. Email: khannas@ccf.org OPEN
a克利夫兰诊所基金会麻醉研究所心胸麻醉科。美国克利夫兰。b克利夫兰临床基金会麻醉研究所全身麻醉科。美国克利夫兰。c克利夫兰临床基金会麻醉学研究所结果研究部。美国克利夫兰。d克利夫兰临床基金会麻醉学研究所重症监护与复苏科。美国克利夫兰。通讯:克利夫兰诊所基金会麻醉研究所,欧几里得大道9500号,E3-108,克利夫兰诊所基金会,俄亥俄州克利夫兰44122,美国,心肺麻醉科,全身麻醉科和结局研究部。邮箱:khannas@ccf.org OPEN
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引用次数: 0
Risk factors of self-extubation in intensive care. Retrospective cohort study 重症监护中自我拔管的危险因素。回顾性队列研究
Q3 Medicine Pub Date : 2022-09-15 DOI: 10.5554/22562087.e1050
Carlos Eduardo Laverde-Sabogal, Carmelo José Espinosa-Almanza, D. Patiño-Hernández, Horacio Rodríguez-Escallón, Juan Camilo Aguado-Valderrama, P. Lara-Monsalve
Introduction: Acute respiratory failure remains one of the three leading causes of admission to the intensive care unit (ICU). Self-extubation is an adverse outcome requiring reintubation in 50% of cases. Objective: To assess for determinants (risk factors) of self-extubation and mortality in the ICU by using a generalized estimation equation model (GEE). Methods: The data was collected from a retrospective cohort study from 2017-2020 including all patients admitted to the ICU with mechanical ventilation. Univariate and bivariate analyses were performed. Then, a GEE model was conducted to predict the risk of self-extubation and mortality. Results: A total of 857 subjects were included, with a mean age of 60.5 +/- 17 years-old. Most of the subjects were males (55.2%). An 8.99-fold risk (95%CI 3.83-21.1, p<0.01) of self-extubation was identified in patients with agitation. Exposure to infusion of neuromuscular blockade was also found to increase the risk of self-extubation 3.37 times (95%CI 1.31-8.68, p=0.01). No associations were identified between immobilization and self-extubation (OR 1.38 95%CI 0.76-2.51, p=0.29). Finally, light sedation according to the Richmond Sedation Scale (RASS) between 0 to -2 rather than moderate (RASS-3) reduces the risk of mortality (OR 0.57, 95%CI 0.38-0.83, p<0.01). Conclusions: The main factors resulting in self-extubation were: agitation, delirium, and infusion of neuromuscular blocking agents. An association was found between light sedation and a lower risk of mortality. No association was found between the use of physical restraint and the desired outcome.
引言:急性呼吸衰竭仍然是入住重症监护室(ICU)的三大主要原因之一。在50%的病例中,自我拔管是需要再次插管的不良结果。目的:应用广义估计方程模型(GEE)评估ICU中自我拔管和死亡率的决定因素(危险因素)。方法:数据收集自2017-2020年的一项回顾性队列研究,包括所有入住ICU并接受机械通气的患者。进行了单变量和双变量分析。然后,进行GEE模型来预测自我拔管的风险和死亡率。结果:共纳入857名受试者,平均年龄为60.5+/-17岁。大多数受试者是男性(55.2%)。在躁动的患者中,自我拔管的风险是8.99倍(95%CI 3.83-21.1,p<0.01)。暴露于输注神经肌肉阻滞剂也会使自拔管的风险增加3.37倍(95%CI 1.31-8.68,p=0.01)。固定和自拔管之间没有关联(OR 1.38,95%CI 0.76-2.51,p=0.29)。最后,根据里士满镇静量表(RASS),0至-2而非中度(RAS-3)的轻度镇静可降低死亡率(OR 0.57,95%CI 0.38-0.83,p<0.01)。结论:导致自我拔管的主要因素是:激动、谵妄和输注神经肌肉阻滞剂。研究发现轻度镇静与较低的死亡率之间存在关联。未发现使用身体约束与预期结果之间存在关联。
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引用次数: 0
Choosing Wisely 明智选择
Q3 Medicine Pub Date : 2022-08-03 DOI: 10.5554/22562087.e1047
Wendy Levinson, M. Giraldo
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引用次数: 0
Ethical principles and dilemmas in the discourse of healthcare practitioners involved with end-of-life care based on the Advanced Directives Document 基于高级指令文件的参与临终关怀的医疗从业者话语中的伦理原则和困境
Q3 Medicine Pub Date : 2022-07-07 DOI: 10.5554/22562087.e1046
Ana Milena Álvarez Acuña, Julián Camilo Riaño Moreno, Jhonatan López Neira, Ómar Fernando Gomezese Ribero
Introduction. The Advanced Directives Document (ADD) is an efficient tool to plan for future medical care in case of a potential loss of autonomy. Ethical dilemmas arise in end-of-life care, including the principle of respect for autonomy and potential beneficence involved in health care, leading to moral distress of practitioners. Objective. To identify the ethical principles and dilemmas arising from the discourse of healthcare practitioners involved with end-of-life care based on the ADD.   Methodology. Qualitative study with a hermeneutics approach based on 253 answers to the following exploratory question: Are you willing to respect the ADD of an unconscious patient when you think that the patient may benefit otherwise?   Results. Most practitioners acknowledge their respect for the ADD as an ethical obligation, whilst a minority consider it a legal right. For the large majority of practitioners, the ethical principles of respect for the ADD are recognized under the ethical theory of liberal individualism. Respect for autonomy is associated with the principle of non-maleficence and the value of human dignity. The principle of beneficence and the quality of life concept were presented as genuine moral dilemmas. A reversible clinical condition, the request for euthanasia, the family and the legibility of anticipated directives were submitted as apparent moral dilemmas. Conclusions. During the end-of-life decision making process, there are other valid ethical considerations beyond principlism. The dilemmas identified show the ethical complexity healthcare practitioners face based on the ADD.
介绍高级指令文件(ADD)是在潜在丧失自主性的情况下规划未来医疗保健的有效工具。临终关怀中出现了道德困境,包括尊重医疗保健中的自主性和潜在利益的原则,导致从业者的道德困境。客观的确定参与基于ADD的临终关怀的医疗从业者的话语中产生的伦理原则和困境。方法论。基于以下探索性问题的253个答案的解释学方法的定性研究:当你认为患者可能从其他方面受益时,你愿意尊重无意识患者的ADD吗?结果。大多数从业者承认他们对ADD的尊重是一项道德义务,而少数人则认为这是一项法律权利。对于绝大多数从业者来说,尊重ADD的伦理原则是在自由个人主义的伦理理论下得到认可的。尊重自主权与不伤害原则和人的尊严价值相联系。慈善原则和生活质量概念被认为是真正的道德困境。可逆的临床状况、安乐死的请求、家庭和预期指令的易读性被认为是明显的道德困境。结论。在临终决策过程中,除了原则主义之外,还有其他有效的伦理考虑。所发现的困境显示了基于ADD的医疗从业者所面临的道德复杂性。
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引用次数: 0
Factors associated with posoperative mortality in high perioperative risk patients. Cohort study 高围手术期风险患者可能手术死亡率的相关因素。队列研究
Q3 Medicine Pub Date : 2022-06-28 DOI: 10.5554/22562087.e1045
V. H. González Cárdenas, Ilia Marcela Jáuregui Romero, Yonny Mena Méndez, Paola Nathaly Silva Enríquez, Andrés Soler Sandoval
Introduction: Determining perioperative risk is part of the strategies implemented with the aim of reducing morbidity and mortality in the surgical population in the world. Although there is no established definition, high perioperative risk is associated with the group of patients with the highest disease burden. Objective: To determine postoperative mortality and its associated factors in patients with high perioperative risk. Methods: Analytical observational cohort study of high perioperative risk patients included in the database (n = 843) of the anesthesia program in a high complexity hospital in Colombia, between January 2011 and April 2018. Pre and postoperative variables were analyzed using uni and multivariate logistic regression per protocol. Overall and stratified mortality were estimated and factors associated with their occurrence were analyzed. Finally, survival was analyzed, the primary outcome being overall cohort mortality and stratified high cardiovascular risk mortality. Results: Cumulative 7-day mortality was 3.68% (95% CI 2.40-4.95%) and 30-day mortality was 10.08% (95% CI 8.05-12.12%). Perioperative mortality in the high cardiovascular risk group in the first 7 days was 3.60% (95% CI 1.13-6.07%) and 14.86% (95% CI 10.15-19.58%) at 30 days. The following preoperative variables were associated with mortality: chronic obstructive pulmonary disease, chronic kidney disease, limited functional class and abdominal aortic aneurysm. A strong association was observed between postoperative complications and a significant increase in mortality rate; the most relevant complications were cerebrovascular events and cardiogenic shock. Conclusions: In this group of high perioperative risk patients,  and in the subgroup of high cardiovascular risk patients, overall mortality at 7 and at 30 days was estimated to be above values reported in various countries. Mortality was significantly increased by the presence of preoperative factors and postoperative complications.
前言:确定围手术期风险是世界范围内降低手术人群发病率和死亡率的战略实施的一部分。虽然没有明确的定义,但围手术期高风险与疾病负担最高的患者群体相关。目的:探讨围手术期高危患者的术后死亡率及其相关因素。方法:2011年1月至2018年4月,对哥伦比亚一家高复杂性医院麻醉项目数据库中的高危患者(n = 843)进行分析性观察队列研究。每个方案使用单变量和多变量逻辑回归分析术前和术后变量。估计总体死亡率和分层死亡率,并分析其发生的相关因素。最后,对生存率进行分析,主要结局是总队列死亡率和分层心血管高危死亡率。结果:累计7天死亡率为3.68% (95% CI 2.40 ~ 4.95%), 30天死亡率为10.08% (95% CI 8.05 ~ 12.12%)。高危组围手术期前7天死亡率为3.60% (95% CI 1.13-6.07%), 30天死亡率为14.86% (95% CI 10.15-19.58%)。以下术前变量与死亡率相关:慢性阻塞性肺疾病、慢性肾脏疾病、功能受限分类和腹主动脉瘤。观察到术后并发症与死亡率显著增加之间存在密切关联;最相关的并发症是脑血管事件和心源性休克。结论:在这组围手术期高危患者和心血管高危患者亚组中,7天和30天的总死亡率估计高于各国报告的值。由于术前因素和术后并发症的存在,死亡率明显增加。
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引用次数: 0
期刊
Colombian Journal of Anesthesiology
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