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Physiological Aspects of Vestibular Schwannoma Treated with Radiosurgery 放射外科治疗前庭神经鞘瘤的生理特征
Pub Date : 2021-03-01 DOI: 10.33552/OJOR.2021.04.000590
Y. Kida
Disequilibrium is one of the most popular symptoms of vestibular schwannoma, next to the hearing disturbance and tinnitus. In our institute, the cases with vestibular schwannoma were concurrently investigated with neurophysiological studies like pure tone hearing of Gardner-Robertson method (GR), auditory brainstem response (ABR), vestibular evoked myogenic potential (VEMP) and Stabilometry. Among them, VEMP study gives us the most valuable informations. In fact, both qualitative and quantitative improvements of VEMP have been verified in association with the symptomatic recovery of disequilibrium.
不平衡是前庭神经鞘瘤最常见的症状之一,仅次于听力障碍和耳鸣。本院对前庭神经鞘瘤患者同时进行Gardner-Robertson法纯音听力(GR)、听性脑干反应(ABR)、前庭诱发肌电位(VEMP)和稳定性测定等神经生理学研究。其中,VEMP研究为我们提供了最有价值的信息。事实上,VEMP的定性和定量改善已被证实与不平衡的症状恢复有关。
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引用次数: 0
Recurrent Laryngeal Nerve Palsy in Sarcoidosis Diagnosis and Management 喉返神经麻痹结节病的诊断与治疗
Pub Date : 2021-02-09 DOI: 10.33552/OJOR.2021.04.000589
M. Elamin
Objectives: Vocal cord palsy secondary to sarcoidosis is a rare manifestation and it is very unusual for the patient to present with it as a chief complaint. This is the first literature review conducted highlighting the importance of this condition. 46 years lady presented with hoarseness of voice without any significant history related to upper airway or lung condition. Suffers only from obesity. Naso-endoscopic examinations showed left vocal cord palsy. CT scan of chest confirmed hilar lymphadenopathy which was diagnosed as sarcoidosis with endobronchial ultrasound (EBUS) guided lymph node biopsy. Symptoms were related to neuro-sarcoidosis and peripheral recurrent laryngeal nerve neuritis. No local compressive sings noted on imaging. The patient was treated with local vocal cord injection and steroids were not suggested considering the patient’s obesity. Methods: The literature review revealed only twenty-three reported cases. Number of cases included were 16 in relation to the nerve pathway. Cranial cases were excluded. One case report was due to peripheral neuro-sarcoidosis. Results: The common practice was to manage with oral steroids, however, only few cases used injection laryngoplasty as treatment. Injection laryngoplasty is actively practiced in the UK under the National Institute of health and care Excellence (NICE) guidelines [ IPG130] was published on the 22nd of June 2005. Conclusion: Knowledge about vocal fold paralysis in sarcoidosis needs highlighting and should be considered by clinicians in cases that may initially appear to be idiopathic in nature without any chest complains related.
目的:声带麻痹继发于结节病是一种罕见的表现,病人以结节病为主诉是很不寻常的。这是第一次强调这种情况的重要性的文献综述。46岁,女性,声音嘶哑,无明显上呼吸道或肺部病史。患的只是肥胖。鼻内窥镜检查显示左声带麻痹。胸部CT扫描证实肺门淋巴结病变,支气管超声引导下淋巴结活检诊断为结节病。症状与神经结节病和周围喉返神经炎有关。影像学未见局部压痕。患者接受局部声带注射治疗,考虑到患者肥胖,不建议使用类固醇。方法:文献回顾23例报告病例。包括16例与神经通路有关的病例。排除颅内病例。1例报告是由于周围神经结节病。结果:常见的做法是口服类固醇治疗,但只有少数病例采用注射喉成形术治疗。根据2005年6月22日发布的国家健康和护理卓越研究所(NICE)指南[IPG130],注射喉部成形术在英国得到了积极的实践。结论:结节病中声带麻痹的知识需要强调,临床医生在最初可能表现为特发性而没有任何胸痛相关的病例中应考虑到这一点。
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引用次数: 0
Brachial Plexus Schwannoma: Case Report 臂丛神经鞘瘤1例
Pub Date : 2021-01-28 DOI: 10.33552/OJOR.2021.04.000588
S. Touihmi
Introduction: Brachial plexus schwannomas is a rare entity, only about 5% arise from the brachial plexus. The diagnosis can be a challenge to surgeons. we provide a case report of a brachial plexus schwannoma and we highlight the clinical aspects of these tumors, the role of imaging in the diagnosis, the surgical treatment, and its outcomes.. Case Report: A 62-year-old male patient, presented with a slowly growing neck mass that had been noted for more than 20 years, associated with slowly evolving weakness of the left upper limb. clinically a 4 x 5 cm mass located in the left supraclavicular region was found. (CT) showed a well- encapsulated, low-density mass near the cervical spinal root. The mass was excised through a supraclavicular incision. The histopathology of the tumor was consistent with Schwannoma. A neurological deficit of the left arm was found immediately after the operation. The patient received sessions of rehabilitation therapy only. Six months later, the motor neurological functions had partially recovered. Discussion: Schwannomas are indolent tumors but may present with symptoms secondary to nerve compression. Clinically, the most common presenting symptoms are palpable mass, pain paresthesia/numbness, and weakness. Contrast-enhanced CT and magnetic resonance images (MRI) are helpful in the pre-operative diagnosis. MR imaging is the study of choice to delineate the margins of the tumor from surrounding tissues with the greatest contrast. The choice of surgical approach is important and can be selected according to the tumor size, tumor site, and relationship with adjacent organs. A variety of surgical approaches are used. Recently, intracapsular enucleation has been introduced to preserve the neurological functions, it is possible to open the capsule and shell out the tumor, thereby leaving the capsular nerve undisturbed and possibly avoiding functional deficits [1]. Despite the extrafascicular characterization of the tumor, it is almost always possible to find a small fascicle entering and exiting the proximal and distal poles of the tumors, such as in our reported case. This fascicle does not transmit nerve action potential and can be sectioned so that the tumor can be.
臂丛神经鞘瘤是一种罕见的肿瘤,仅5%发生于臂丛神经。诊断对外科医生来说是一个挑战。我们提供一例臂丛神经鞘瘤的病例报告,我们强调这些肿瘤的临床方面,成像在诊断中的作用,手术治疗,和它的结果。病例报告:一名62岁男性患者,表现为缓慢增长的颈部肿块,已经注意到超过20年,并伴有缓慢发展的左上肢无力。临床发现左侧锁骨上区有一个4 × 5 cm的肿块。(CT)显示在颈椎根附近有一个包被良好的低密度肿块。肿块通过锁骨上切口切除。肿瘤的组织病理学符合神经鞘瘤。手术后立即发现左臂有神经缺陷。患者只接受了几次康复治疗。6个月后,运动神经功能部分恢复。讨论:神经鞘瘤是一种惰性肿瘤,但可能出现继发于神经压迫的症状。临床上,最常见的症状是可触及的肿块、疼痛、感觉异常/麻木和虚弱。对比增强CT和磁共振成像(MRI)有助于术前诊断。磁共振成像是一种选择的研究,以最大的对比从周围组织划定肿瘤的边缘。手术入路的选择很重要,可以根据肿瘤的大小、肿瘤的部位以及与邻近器官的关系来选择。使用多种手术入路。最近,囊内去核术被引入以保留神经功能,它可以打开囊并剥出肿瘤,从而使囊神经不受干扰,并可能避免功能缺陷[1]。尽管肿瘤具有束外特征,但几乎总是可以发现一个小束进入和离开肿瘤的近端和远端,如我们报道的病例。这个神经束不传递神经动作电位可以被切开,这样肿瘤就可以。
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引用次数: 0
Advances in Endoscopic Sinus Surgery Technique: The Impact of Technological Breakthroughs 内窥镜鼻窦手术技术进展:技术突破的影响
Pub Date : 2021-01-05 DOI: 10.33552/OJOR.2021.04.000587
F. Kuhn
Messerklinger initially characterized sinonasal mucociliary clearance patterns in the 1950’s using India ink particles and hypothesized that inflammatory disease within the sinuses, as well as anatomic variants, could obstruct mucus outflow. He introduced use of the endoscope for diagnostic evaluation, as well as surgical principles known as the Messerklinger technique [1]. In the following 70 years his technique, known as Endoscopic Sinus Surgery (ESS), was refined and popularized by Stammberger, Kennedy, and others [2,3]. Both emphasized the preservation of normal anatomic structures and re-establishment of natural mucociliary clearance patterns. Towards that end, Kennedy viewed the surgery as a functional and minimally invasive procedure, adding the term “functional” to ESS, with the procedure now widely known as Functional Endoscopic Surgery (FESS) [4]. Since then, minimally invasive endoscopic techniques have been further refined by a multitude of talented multi-disciplinary physicians, too numerous to name here [5].
Messerklinger最初在20世纪50年代使用墨汁颗粒描述了鼻窦黏液纤毛清除模式,并假设鼻窦内的炎症性疾病以及解剖变异可能阻碍黏液流出。他介绍了使用内窥镜进行诊断评估,以及被称为Messerklinger技术的外科原理[1]。在接下来的70年里,他的技术被称为内窥镜鼻窦手术(ESS),由Stammberger、Kennedy等人改进和推广[2,3]。两者都强调保留正常的解剖结构和重建自然的粘液纤毛清除模式。为此,Kennedy将该手术视为一种功能性和微创手术,并在ESS中加入了“功能性”一词,该手术现在被广泛称为功能性内窥镜手术(FESS)[4]。从那时起,微创内镜技术被众多才华横溢的多学科医生进一步完善,不胜枚举[5]。
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引用次数: 0
Cochlear Synaptopathy in Humans. Review of the Evidence and Future Directions 人类耳蜗突触病。证据回顾和未来发展方向
Pub Date : 2020-12-14 DOI: 10.33552/OJOR.2020.04.000586
G. Panagiotopoulos
Cochlear synapthopathy, is a condition where the damage is located at the level of the synapses between IHCs and type-I afferent auditory nerve fibres. The disrupted function of these synapses, either can or can’t be re-established, thus resulting in various signal coding deficits and hearing impairment. Cochlear synaptopathy can be widely present in ears with intact hair cell populations and relatively ‘normal’ audiograms, representing the major cause of “hidden” hearing loss. The present study reviews the major mechanisms involved in hidden hearing loss, emphasizing on future directions regarding appropriate diagnosis of cochlear synaptopathy in humans.
耳蜗突触病,是一种损伤位于ihc和i型传入听神经纤维之间的突触水平的情况。这些突触的功能被破坏,要么不能重建,要么不能重建,从而导致各种信号编码缺陷和听力障碍。耳蜗突触病可广泛存在于毛细胞群完整、听音图相对“正常”的耳朵中,是“隐性”听力损失的主要原因。本研究综述了隐蔽性听力损失的主要机制,强调了人类耳蜗突触病的正确诊断的未来方向。
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引用次数: 0
Diagnostic Assessment of Progressive Fluctuating Sensorineural Hearing Loss in Children 儿童进行性波动感音神经性听力损失的诊断评估
Pub Date : 2020-12-11 DOI: 10.33552/OJOR.2020.04.000585
G. Panagiotopoulos
Deterioration of auditory thresholds in young children is directly associated with negative impact on language development. Early detection of the cause of sensorineural hearing loss eases proper intervention and signalizes valuable prognostic data. Nowadays, the etiology of pediatric hearing loss has been modified, attributable to progresses in gene testing and adequate management of birth infections. This paper updates well known risk factors for progression along with fluctuation of hearing acuity involving health hazard indicators, auditory, laboratory and clinical manifestations of such young patients. This review takes into consideration the most well-known risk indicators associated with an increased likelihood of progressive hearing loss (including but not limited to neonatal intensive care unit admission, family history of hearing loss, various syndromes, prenatal and postnatal infections etc.). Prompt post neonatal monitoring of hearing, leading to early hearing loss identification, is crucial to optimize management and therefore appropriate intervention.
幼儿听觉阈值的下降与语言发展的负面影响直接相关。早期发现感音神经性听力损失的原因有助于进行适当的干预,并提供有价值的预后数据。如今,由于基因检测的进步和对出生感染的适当管理,儿童听力损失的病因学已经有所改变。本文更新了众所周知的听力敏锐度随听力波动而恶化的危险因素,包括健康危害指标、听力、实验室和临床表现。本综述考虑了与进行性听力损失可能性增加相关的最知名的风险指标(包括但不限于新生儿重症监护病房入院、听力损失家族史、各种综合征、产前和产后感染等)。新生儿后及时监测听力,从而早期发现听力损失,对于优化管理和适当干预至关重要。
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引用次数: 0
Giant Pleomorphic Adenoma of the Parapharyngeal Space: A Case Report and Review of the Literature 咽旁间隙巨大多形性腺瘤1例报告及文献复习
Pub Date : 2020-11-25 DOI: 10.33552/OJOR.2020.04.000583
M. Beghdad
Neoplasms of the parapharyngeal space are extremely rare and represent 0.5% of all tumors of the head and neck. The majority of the mare benign and originate in the salivary gland region. Pleomorphic adenoma is the most common salivary glandular benign tumor. We report the case of a 44-year-old woman presented with the complaint of a dysphagia and swelling of the left soft palate. Cervical computed tomography showing very limited mass in the left parapharyngeal space. The patient was operated on and total excision of the lesion was carried out using a trans-oral approach. Histological examination revealed a pleomorphic adenoma. No post-surgical complications were noted. No recurrence was noted during the 2 years of follow-up.
咽旁间隙的肿瘤极为罕见,占头颈部所有肿瘤的0.5%。大多数马是良性的,起源于唾液腺区域。多形性腺瘤是最常见的涎腺良性肿瘤。我们报告的情况下,44岁的妇女提出申诉吞咽困难和肿胀的左软腭。颈椎电脑断层显示左侧咽旁间隙有非常有限的肿块。患者接受了手术,并采用经口入路对病变进行了完全切除。组织学检查为多形性腺瘤。无术后并发症。随访2年无复发。
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引用次数: 0
Current Perspectives in Meniere’s Disease Treatment: A Mini Review 梅尼埃病治疗的最新进展:综述
Pub Date : 2020-11-20 DOI: 10.33552/OJOR.2020.04.000582
G. Panagiotopoulos
Meniere’s disease (MD) is a chronic heterogeneous disorder recently found to involve multiple rare and common variants in several genes. It almost always necessitates management for a sustained period of time. Treatment options focus on improving quality of life in MD patients. Control is not always easy to achieve, requiring multidrug treatments, and even surgical procedures. Migraine, dyslipidemia, obesity, diabetes, sleep apnea, hypertension, and atherosclerosis are among the major diseases that are associated with MD and often require medical management. Migraine prophylaxis and trigger elimination, magnesium supplementation, low sodium intake, diuretics, anticoagulants, and antihypertensives are among the treatments used initially. Steroids administered orally or intratympanically are used if medical control is not beneficial. Ablation remains the definitive treatment in unilateral cases experiencing management failure, thus facilitating a customized vestibular rehabilitation protocol. Genetic study should be implemented especially when familial MD is considered. Proper gene variance targeting in MD can provide in the immediate future candidates for potential gene therapy.
梅尼埃氏病(MD)是一种慢性异质性疾病,最近发现涉及几个基因的多种罕见和常见变异。它几乎总是需要持续一段时间的管理。治疗选择侧重于改善MD患者的生活质量。控制并不总是容易的,需要多种药物治疗,甚至外科手术。偏头痛、血脂异常、肥胖、糖尿病、睡眠呼吸暂停、高血压和动脉粥样硬化是与MD相关的主要疾病,通常需要医疗管理。偏头痛的预防和诱因消除、镁补充、低钠摄入、利尿剂、抗凝血剂和抗高血压药是最初使用的治疗方法。如果药物控制无效,可口服或腹腔注射类固醇。消融仍然是治疗失败的单侧病例的最终治疗方法,因此有助于定制前庭康复方案。尤其在考虑家族性MD时,应进行遗传学研究。适当的基因变异靶向治疗可以在不久的将来为潜在的基因治疗提供候选药物。
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引用次数: 0
Diagnostic Dilemma: Presenting as A Posterior Neck Swelling 诊断困境:表现为后颈部肿胀
Pub Date : 2020-11-13 DOI: 10.33552/OJOR.2020.04.000580
Islam Ma
Neck swelling is a common presentation in the general population and has a number of possible causes. Lymph nodes are the commonest among all. Schwannomas are benign slow growing tumors that arise from the Schwann cells of nerve, also called neurilemmoma. Head and Neck schwannomas usually present as solitary with well demarcated lesions. These tumors usually remain asymptomatic but present as slowly enlarging neck masses. Its origin is only determined during surgical procedure along the course and distribution of the nerve. Preoperative diagnosis is usually made by physical examination and aided by ultrasonography, magnetic resonance imaging or computed tomography and fine needle aspiration cytology but open biopsy is not recommended. The main stay of treatment is complete intracapsular excision with preserving the nerve of origin.
颈部肿胀在一般人群中是一种常见的表现,有许多可能的原因。淋巴结是最常见的。神经鞘瘤是一种生长缓慢的良性肿瘤,起源于神经的雪旺细胞,也称为神经鞘瘤。头颈部神经鞘瘤通常表现为孤立的,病灶界限清楚。这些肿瘤通常无症状,但表现为颈部缓慢增大的肿块。它的起源只能在外科手术中确定,沿着神经的路线和分布。术前诊断通常通过体格检查,并辅以超声检查、磁共振成像或计算机断层扫描和细针穿刺细胞学,但不建议进行开放式活检。治疗的主要目的是在保留原神经的情况下进行囊内完全切除。
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引用次数: 0
Fixed Drug Eruption Due to A Cerumenolytic Ear Drop; Hydrogen Peroxide and Boric Acid: A Case Report 溶耵聍滴耳液所致固定药疹过氧化氢与硼酸:1例报告
Pub Date : 2020-11-03 DOI: 10.33552/ojor.2020.04.000577
A. Islek
Treatment of earwax often involves the use of a wax softening agent (cerumenolytic) with or without antimicrobial agents to easily removing. Cerumenolytic agents used to remove and soften earwax areoil-based treatments, water-based treatments. Fixed drug eruption (FDE) is a well-defined, circular, hyperpigmented plaque that usually occurs on the trunk, hands mucosal surfaces, after a systemical application of drugs. In this report, a case with FDE developed after a cerumenolytic agent (hydrogen peroxide and boric acid in water). A definitive diagnosis was made with skin punch biopsy and FDE was treated with oral levocetirizine and topical mometasone.
耳垢的治疗通常涉及使用蜡软化剂(溶耳剂),或不使用抗菌剂,以轻松去除。用于去除和软化耳垢的溶耵聍剂有油基治疗和水基治疗。固定药疹(FDE)是一种轮廓清晰、圆形、色素沉着的斑块,通常发生在全身用药后的躯干、手部粘膜表面。在本报告中,一个病例的FDE发展后的脑炎溶解剂(过氧化氢和硼酸在水中)。通过皮肤穿刺活检确诊FDE,口服左西替利嗪和外用莫米松治疗。
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引用次数: 0
期刊
Online Journal of Otolaryngology and Rhinology
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