首页 > 最新文献

Journal of Patient-Reported Outcomes最新文献

英文 中文
Anthropometric estimates can predict satisfaction with breast in a population of asymptomatic women. 人体测量估计值可预测无症状妇女对乳房的满意度。
IF 2.4 Q2 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-11-28 DOI: 10.1186/s41687-024-00814-9
Giuseppe Catanuto, Valentina Di Salvatore, Concetta Fichera, Patrizia Dorangricchia, Valeria Sebri, Nicola Rocco, Gabriella Pravettoni, Francesco Caruso, Francesco Pappalardo
<p><strong>Background: </strong>Several authors hypothesized that normative values of breast related quality of life in asymptomatic populations can be helpful to better understand changes induced by surgery. Breast related quality of life can be associated to breast anthropometry. This study was designed to explore this hypothesis, find relevant correlations and, using machine learning techniques, predict values of satisfaction with breast from easy body measurements.</p><p><strong>Methods: </strong>Asymptomatic women undergoing routine clinical examination for breast cancer prevention were interviewed using the BREAST_Q V1 Breast Conserving Surgery Pre-op. Descriptive statistics was performed to describe the characteristics of the population. The Pearson correlation test defined correlation between relevant anthropometric variables and scores in each domain of the BREAST_Q. Regression analysis was employed to assess variation in the "Satisfaction with breast" domain when looking at the mirror dressed or undressed. Three machine learning algorithms were tested to predict scores in the "Satisfaction with breast domain" given body mass index and nipple to sternal notch distance.</p><p><strong>Results: </strong>One-hundred and twenty-five women underwent clinical examination and assessment of anthropometry. The reply rate to the BREAST_Q ranged from 99.2 to 88% depending on the domains. The "satisfaction with breast" domain was negatively associated either to BMI [r<sub>Pearson</sub> = -0.28, CI (-0.41, -0.15) p < 0.005] and Age [r<sub>Pearson</sub> = -0.15, CI (-0.29, -6.52e-03) p = 0.04]. The N_SN distance was also negatively associated to this domain with the following values for the right [r<sub>Pearson</sub> = -0.34, CI (-0.45, -0.21) p < 0.000] and left side [r<sub>Pearson</sub> = -0.31, CI (-0.43, -0.17) p < 0.000]. Linear regression analysis was performed on questions 1 and 4 of the "Satisfaction with Breast" domain revealing a steeper decrease for women with higher BMI values looking in the mirror undressed (Adjusted R-squared BMI: Dressed - 0.03329/Undressed - 0.08186). The combination of two parameters (BMI and N_SN distance) generated the following accuracy values respectively for three machine learning algorithms: MAP (Accuracy = 0.37, 95% CI: (0.2939, 0.4485)); Naïve Bayes (Accuracy = 0.70, 95% CI: (0.6292, 0.7755); SVM (Accuracy = 0.63, 95% CI: (0.5515, 0.7061)).</p><p><strong>Conclusions: </strong>This study generates normative scores for a Mediterranean population of asymptomatic women and demonstrates relevant associations between anthropometry and breast related quality of life. Machine learning techniques may predict scores of the "satisfaction with breast" domain of the Breast_Q using body mass index and nipple to sternal notch estimates as input. However, the algorithm seems to fail in approximately one third of the sample probably because is not able to capture many aspects of personal life. Much larger sample and more qualit
背景:一些作者假设,无症状人群中与乳房相关的生活质量的标准值有助于更好地理解手术引起的变化。乳房相关生活质量可能与乳房人体测量有关。本研究旨在探索这一假设,找到相关的关联性,并利用机器学习技术从简单的身体测量结果中预测乳房满意度值:方法:使用 BREAST_Q V1 保乳手术术前问卷对接受常规临床检查以预防乳腺癌的无症状女性进行访谈。采用描述性统计来描述人群特征。皮尔逊相关性检验确定了相关人体测量变量与 BREAST_Q 各领域得分之间的相关性。回归分析用于评估穿衣或脱衣照镜子时 "乳房满意度 "域的变化。根据体重指数和乳头到胸骨切迹的距离,对三种机器学习算法进行了测试,以预测 "乳房满意度 "领域的得分:125名妇女接受了临床检查和人体测量评估。对 BREAST_Q 的回答率从 99.2% 到 88% 不等,具体取决于各领域。对乳房的满意度 "领域与体重指数呈负相关[rPearson = -0.28, CI (-0.41, -0.15) p Pearson = -0.15, CI (-0.29, -6.52e-03) p = 0.04]。N_SN 距离与该领域也呈负相关,右侧的数值如下[rPearson = -0.34, CI (-0.45, -0.21) p Pearson = -0.31, CI (-0.43, -0.17) p 结论:这项研究为地中海地区的无症状女性人群生成了标准分数,并证明了人体测量与乳房相关生活质量之间的相关性。机器学习技术可以使用体重指数和乳头至胸骨切迹的估计值作为输入,预测乳房质量调查表中 "对乳房的满意度 "领域的分数。然而,该算法似乎在大约三分之一的样本中失效,这可能是因为该算法无法捕捉到个人生活的许多方面。在确定身体估计值与生活质量之间的任何直接联系之前,需要更大的样本和更多的定性研究。本文还给出了临床意义。
{"title":"Anthropometric estimates can predict satisfaction with breast in a population of asymptomatic women.","authors":"Giuseppe Catanuto, Valentina Di Salvatore, Concetta Fichera, Patrizia Dorangricchia, Valeria Sebri, Nicola Rocco, Gabriella Pravettoni, Francesco Caruso, Francesco Pappalardo","doi":"10.1186/s41687-024-00814-9","DOIUrl":"https://doi.org/10.1186/s41687-024-00814-9","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Several authors hypothesized that normative values of breast related quality of life in asymptomatic populations can be helpful to better understand changes induced by surgery. Breast related quality of life can be associated to breast anthropometry. This study was designed to explore this hypothesis, find relevant correlations and, using machine learning techniques, predict values of satisfaction with breast from easy body measurements.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Asymptomatic women undergoing routine clinical examination for breast cancer prevention were interviewed using the BREAST_Q V1 Breast Conserving Surgery Pre-op. Descriptive statistics was performed to describe the characteristics of the population. The Pearson correlation test defined correlation between relevant anthropometric variables and scores in each domain of the BREAST_Q. Regression analysis was employed to assess variation in the \"Satisfaction with breast\" domain when looking at the mirror dressed or undressed. Three machine learning algorithms were tested to predict scores in the \"Satisfaction with breast domain\" given body mass index and nipple to sternal notch distance.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;One-hundred and twenty-five women underwent clinical examination and assessment of anthropometry. The reply rate to the BREAST_Q ranged from 99.2 to 88% depending on the domains. The \"satisfaction with breast\" domain was negatively associated either to BMI [r&lt;sub&gt;Pearson&lt;/sub&gt; = -0.28, CI (-0.41, -0.15) p &lt; 0.005] and Age [r&lt;sub&gt;Pearson&lt;/sub&gt; = -0.15, CI (-0.29, -6.52e-03) p = 0.04]. The N_SN distance was also negatively associated to this domain with the following values for the right [r&lt;sub&gt;Pearson&lt;/sub&gt; = -0.34, CI (-0.45, -0.21) p &lt; 0.000] and left side [r&lt;sub&gt;Pearson&lt;/sub&gt; = -0.31, CI (-0.43, -0.17) p &lt; 0.000]. Linear regression analysis was performed on questions 1 and 4 of the \"Satisfaction with Breast\" domain revealing a steeper decrease for women with higher BMI values looking in the mirror undressed (Adjusted R-squared BMI: Dressed - 0.03329/Undressed - 0.08186). The combination of two parameters (BMI and N_SN distance) generated the following accuracy values respectively for three machine learning algorithms: MAP (Accuracy = 0.37, 95% CI: (0.2939, 0.4485)); Naïve Bayes (Accuracy = 0.70, 95% CI: (0.6292, 0.7755); SVM (Accuracy = 0.63, 95% CI: (0.5515, 0.7061)).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;This study generates normative scores for a Mediterranean population of asymptomatic women and demonstrates relevant associations between anthropometry and breast related quality of life. Machine learning techniques may predict scores of the \"satisfaction with breast\" domain of the Breast_Q using body mass index and nipple to sternal notch estimates as input. However, the algorithm seems to fail in approximately one third of the sample probably because is not able to capture many aspects of personal life. Much larger sample and more qualit","PeriodicalId":36660,"journal":{"name":"Journal of Patient-Reported Outcomes","volume":"8 1","pages":"137"},"PeriodicalIF":2.4,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How to interpret patient-reported outcomes? - Stratified adjusted minimal important changes for the EQ-5D-3L in hip and knee replacement patients. 如何解释患者报告的结果?- 髋关节和膝关节置换术患者 EQ-5D-3L 的分层调整最小重要变化。
IF 2.4 Q2 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-11-25 DOI: 10.1186/s41687-024-00812-x
Irene Salvi, David Ehlig, Justus Vogel, Anja Bischof, Alexander Geissler

Background: As one of the main goals of hip and knee replacements is to improve patients' health-related quality of life, a meaningful evaluation can be achieved by calculating minimal important changes (MICs) for improvements in patient-reported outcome measures (PROMs). This study aims at providing MICs adjusted for patient characteristics for EQ-5D-3L index score improvements after hip and knee replacements. It adds to existing literature by relying on a large national sample and precise clustering algorithms, and by employing a state-of-the-art methodology for the calculation of improved adjusted MICs.

Methodology: A retrospective observational study was conducted using the publicly available National Health Service (NHS) PROMs dataset for primary hip and knee replacements. We used information on 252,331 hip replacements and 279,668 knee replacements from all NHS-funded providers in England between 2013 and 2020. Clusters of patients were created based on pre-operative EQ-VAS, depression status, and sex. Unstratified and stratified estimates for meaningful EQ-5D-3L improvements were obtained through anchor-based predictive MICs corrected for the proportion of improved patients and the reliability of transition ratings.

Results: Stratifying patients showed that MICs varied across subgroups based on pre-operative EQ-VAS, depression status, and sex. MICs were larger for patients with worse pre-operative EQ-VAS scores, while patients with better pre-operative scores required smaller MICs to achieve a meaningful change. We show how after stratification the percentage of patients achieving their stratified MIC was better in line with the actual share of improved patients. Larger MICs were found for patients with depression and for female patients. MICs calculated for knee replacements were consistently lower than those for hip replacements.

Conclusions: Our findings show the importance of adjusting MICs for patients' characteristics and should be considered for quality-related choices and policy initiatives.

背景:由于髋关节和膝关节置换术的主要目标之一是改善患者的健康相关生活质量,因此通过计算患者报告结果测量指标(PROMs)改善的最小重要变化(MICs)可以实现有意义的评估。本研究旨在提供髋关节和膝关节置换术后根据患者特征调整的 EQ-5D-3L 指数评分改善的最小重要变化(MIC)。该研究依靠大量的全国样本和精确的聚类算法,并采用最先进的方法计算改进后的调整后 MIC,对现有文献进行了补充:我们使用公开的国民健康服务(NHS)PROMs数据集对初级髋关节和膝关节置换术进行了回顾性观察研究。我们使用了 2013 年至 2020 年期间英格兰所有 NHS 资助医疗机构提供的 252,331 例髋关节置换术和 279,668 例膝关节置换术的信息。根据术前 EQ-VAS、抑郁状态和性别对患者进行分组。通过基于锚点的预测性 MIC,并根据改善患者的比例和过渡评分的可靠性进行校正,得出有意义的 EQ-5D-3L 改善的非分层和分层估计值:对患者进行分层后发现,基于术前 EQ-VAS、抑郁状态和性别,不同亚组的 MICs 有所不同。术前 EQ-VAS 评分较低的患者的 MIC 更大,而术前评分较高的患者需要较小的 MIC 才能实现有意义的改变。我们展示了经过分层后,达到分层 MIC 的患者比例如何更好地与得到改善的患者实际比例保持一致。抑郁症患者和女性患者的 MIC 更大。计算出的膝关节置换术的MIC始终低于髋关节置换术:我们的研究结果表明了根据患者特征调整MICs的重要性,在与质量相关的选择和政策措施中应加以考虑。
{"title":"How to interpret patient-reported outcomes? - Stratified adjusted minimal important changes for the EQ-5D-3L in hip and knee replacement patients.","authors":"Irene Salvi, David Ehlig, Justus Vogel, Anja Bischof, Alexander Geissler","doi":"10.1186/s41687-024-00812-x","DOIUrl":"10.1186/s41687-024-00812-x","url":null,"abstract":"<p><strong>Background: </strong>As one of the main goals of hip and knee replacements is to improve patients' health-related quality of life, a meaningful evaluation can be achieved by calculating minimal important changes (MICs) for improvements in patient-reported outcome measures (PROMs). This study aims at providing MICs adjusted for patient characteristics for EQ-5D-3L index score improvements after hip and knee replacements. It adds to existing literature by relying on a large national sample and precise clustering algorithms, and by employing a state-of-the-art methodology for the calculation of improved adjusted MICs.</p><p><strong>Methodology: </strong>A retrospective observational study was conducted using the publicly available National Health Service (NHS) PROMs dataset for primary hip and knee replacements. We used information on 252,331 hip replacements and 279,668 knee replacements from all NHS-funded providers in England between 2013 and 2020. Clusters of patients were created based on pre-operative EQ-VAS, depression status, and sex. Unstratified and stratified estimates for meaningful EQ-5D-3L improvements were obtained through anchor-based predictive MICs corrected for the proportion of improved patients and the reliability of transition ratings.</p><p><strong>Results: </strong>Stratifying patients showed that MICs varied across subgroups based on pre-operative EQ-VAS, depression status, and sex. MICs were larger for patients with worse pre-operative EQ-VAS scores, while patients with better pre-operative scores required smaller MICs to achieve a meaningful change. We show how after stratification the percentage of patients achieving their stratified MIC was better in line with the actual share of improved patients. Larger MICs were found for patients with depression and for female patients. MICs calculated for knee replacements were consistently lower than those for hip replacements.</p><p><strong>Conclusions: </strong>Our findings show the importance of adjusting MICs for patients' characteristics and should be considered for quality-related choices and policy initiatives.</p>","PeriodicalId":36660,"journal":{"name":"Journal of Patient-Reported Outcomes","volume":"8 1","pages":"136"},"PeriodicalIF":2.4,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing the impact of COVID-19 on outpatient psychiatric population well-being and symptomology utilizing COVID-19 Events Checklist (CEC) and Measurement Based Care. 利用 COVID-19 事件核对表 (CEC) 和基于测量的护理,评估 COVID-19 对门诊精神病患者福祉和症状的影响。
IF 2.4 Q2 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-11-21 DOI: 10.1186/s41687-024-00802-z
Sydney B Jones, Hayoung Ko, Alyssa J Gatto, Anita S Kablinger, Hunter D Sharp, Lee D Cooper, Martha M Tenzer, Virginia C O'Brien, Robert S McNamara

Background: This study examines the impact of SARS-CoV-2 (i.e., coronavirus, COVID, COVID-19) using data from a measurement-based care (MBC) system utilized in an outpatient psychiatric clinic providing telemedicine care. A novel Patient Rated Outcome Measure (PROM), the COVID-19 Events Checklist (CEC) was administered in a hospital system based ambulatory clinic beginning April 2020 to track COVID-19-19's impact on patients' mental, emotional, and health-related behaviors during the pandemic. The study (1) provides descriptive CEC data, and (2) compares CEC results with PROMs evaluating anxiety (Generalized Anxiety Disorder-7; GAD-7), depression (Patient Health Questionnaire; PHQ-9), and psychological distress (Brief Adjustment Scale-6; BASE-6).

Methods: This retrospective observational study included patient intake data collected from April 2020 to March 2021. Patient (N = 842) reports on the CEC's five domain questions were aggregated to calculate average reports of COVID-19 related impacts at intake over the initial 12 months of the pandemic. Trends in COVID-19 related impacts were examined, and non-aggregated scores on the PHQ-9, GAD-7, and BASE-6 were compared to primary dichotomous (yes/no) CEC survey questions via Wilcoxon rand sum testing.

Results: Results capture the relationship between COVID-19 exposure, COVID-19- related sequelae and behaviors, and psychological symptom severity. Specifically, Wilcoxon rank-sum tests indicate that social determinants of health (SDOH), negative mental health impacts, and positive coping skill use were significantly associated with psychological symptomatology including overall psychological functioning via the BASE-6, anxiety via the GAD-7, and depressive symptoms via the PHQ-9. Results regarding SDOH were as follows: BASE-6 (w = 44,005, p < 0.001), GAD-7 (w = 44,116, p < 0.001), and PHQ-9 (w = 43,299, p < 0.001). Regarding negative mental health outcomes, the results were: BASE-6 (w = 38,374, p < 0.001), GAD-7 (w = 39,511, p < 0.001), and PHQ-9 (w = 40,154, p < 0.001). As the initial year of the pandemic elapsed, incoming patients demonstrated increased rates of suspected or confirmed exposure to COVID-19, (+2.29%, t = 3.19, p = 0.01), reported fewer negative impacts of COVID-19 on SDOH (-3.53%, t= -2.45, p = 0.034), and less engagement in positive coping strategies (-1.47%, t = -3.14, p = 0.010).

Conclusions: Psychosocial factors related to COVID-19 are discussed, as well as opportunities for further research on the relationship between psychological symptomatology and the impact of COVID-19 on health-related behaviors.

研究背景本研究利用提供远程医疗服务的精神科门诊使用的基于测量的护理(MBC)系统的数据,研究了SARS-CoV-2(即冠状病毒,COVID,COVID-19)的影响。从 2020 年 4 月开始,在基于医院系统的门诊诊所中实施了一种新的患者评分结果测量(PROM)--COVID-19 事件核对表(CEC),以跟踪 COVID-19-19 在大流行期间对患者心理、情绪和健康相关行为的影响。该研究(1)提供了描述性的 CEC 数据,(2)将 CEC 结果与评估焦虑(广泛性焦虑症-7;GAD-7)、抑郁(患者健康问卷;PHQ-9)和心理困扰(简明适应量表-6;BASE-6)的 PROM 进行了比较:这项回顾性观察研究包括 2020 年 4 月至 2021 年 3 月期间收集的患者入院数据。对患者(N = 842)关于 CEC 五个领域问题的报告进行汇总,以计算大流行最初 12 个月中患者在入院时关于 COVID-19 相关影响的平均报告。对 COVID-19 相关影响的趋势进行了研究,并通过 Wilcoxon rand sum 检验将 PHQ-9、GAD-7 和 BASE-6 的非汇总得分与主要二分法(是/否)CEC 调查问题进行了比较:结果:结果反映了 COVID-19 暴露、COVID-19 相关后遗症和行为与心理症状严重程度之间的关系。具体来说,Wilcoxon 秩和检验表明,健康的社会决定因素(SDOH)、对心理健康的负面影响以及积极应对技能的使用与心理症状(包括通过 BASE-6 测定的整体心理功能、通过 GAD-7 测定的焦虑以及通过 PHQ-9 测定的抑郁症状)有显著相关性。有关 SDOH 的结果如下:BASE-6(w = 44,005,p 结论:BASE-6 与心理症状有关:本文讨论了与 COVID-19 相关的社会心理因素,以及进一步研究心理症状与 COVID-19 对健康相关行为的影响之间关系的机会。
{"title":"Assessing the impact of COVID-19 on outpatient psychiatric population well-being and symptomology utilizing COVID-19 Events Checklist (CEC) and Measurement Based Care.","authors":"Sydney B Jones, Hayoung Ko, Alyssa J Gatto, Anita S Kablinger, Hunter D Sharp, Lee D Cooper, Martha M Tenzer, Virginia C O'Brien, Robert S McNamara","doi":"10.1186/s41687-024-00802-z","DOIUrl":"10.1186/s41687-024-00802-z","url":null,"abstract":"<p><strong>Background: </strong>This study examines the impact of SARS-CoV-2 (i.e., coronavirus, COVID, COVID-19) using data from a measurement-based care (MBC) system utilized in an outpatient psychiatric clinic providing telemedicine care. A novel Patient Rated Outcome Measure (PROM), the COVID-19 Events Checklist (CEC) was administered in a hospital system based ambulatory clinic beginning April 2020 to track COVID-19-19's impact on patients' mental, emotional, and health-related behaviors during the pandemic. The study (1) provides descriptive CEC data, and (2) compares CEC results with PROMs evaluating anxiety (Generalized Anxiety Disorder-7; GAD-7), depression (Patient Health Questionnaire; PHQ-9), and psychological distress (Brief Adjustment Scale-6; BASE-6).</p><p><strong>Methods: </strong>This retrospective observational study included patient intake data collected from April 2020 to March 2021. Patient (N = 842) reports on the CEC's five domain questions were aggregated to calculate average reports of COVID-19 related impacts at intake over the initial 12 months of the pandemic. Trends in COVID-19 related impacts were examined, and non-aggregated scores on the PHQ-9, GAD-7, and BASE-6 were compared to primary dichotomous (yes/no) CEC survey questions via Wilcoxon rand sum testing.</p><p><strong>Results: </strong>Results capture the relationship between COVID-19 exposure, COVID-19- related sequelae and behaviors, and psychological symptom severity. Specifically, Wilcoxon rank-sum tests indicate that social determinants of health (SDOH), negative mental health impacts, and positive coping skill use were significantly associated with psychological symptomatology including overall psychological functioning via the BASE-6, anxiety via the GAD-7, and depressive symptoms via the PHQ-9. Results regarding SDOH were as follows: BASE-6 (w = 44,005, p < 0.001), GAD-7 (w = 44,116, p < 0.001), and PHQ-9 (w = 43,299, p < 0.001). Regarding negative mental health outcomes, the results were: BASE-6 (w = 38,374, p < 0.001), GAD-7 (w = 39,511, p < 0.001), and PHQ-9 (w = 40,154, p < 0.001). As the initial year of the pandemic elapsed, incoming patients demonstrated increased rates of suspected or confirmed exposure to COVID-19, (+2.29%, t = 3.19, p = 0.01), reported fewer negative impacts of COVID-19 on SDOH (-3.53%, t= -2.45, p = 0.034), and less engagement in positive coping strategies (-1.47%, t = -3.14, p = 0.010).</p><p><strong>Conclusions: </strong>Psychosocial factors related to COVID-19 are discussed, as well as opportunities for further research on the relationship between psychological symptomatology and the impact of COVID-19 on health-related behaviors.</p>","PeriodicalId":36660,"journal":{"name":"Journal of Patient-Reported Outcomes","volume":"8 1","pages":"135"},"PeriodicalIF":2.4,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11582237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
International study to develop a patient-reported outcome measure to evaluate outcomes of gender-affirming care - the GENDER-Q. 开展国际研究,制定患者报告的结果测量方法,以评估性别确认护理的结果 - GENDER-Q。
IF 2.4 Q2 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-11-19 DOI: 10.1186/s41687-024-00785-x
Manraj N Kaur, Shane D Morrison, Shelby L Kennedy, Tim C van de Grift, Astrid Højgaard, Amalie Lind Jacobsen, Natasha Johnson, Margriet G Mullender, Lotte Poulsen, Thomas Satterwhite, Richard Santucci, John Semple, Charlene Rae, Kinusan Savard, Jens Ahm Sørensen, Danny Young-Afat, Andrea L Pusic, Anne F Klassen

Background: To meaningfully understand outcomes of gender-affirming care, patient-reported outcome measures (PROMs) that are grounded in what matters to individuals seeking care are urgently needed. The objective of this study was to develop a comprehensive PROM to assess outcomes of gender-affirming care in clinical practice, research, and quality initiatives (the GENDER-Q).

Methods: Internationally established guidelines for PROM development were used to create a field test version of the GENDER-Q. In-depth interviews were conducted from December 2018 to March 2020 with youth and adults aged 16 years and older who were seeking or had received gender-affirming care at outpatient clinics providing gender-affirming care located within tertiary care centers or communities in Canada, Denmark, the Netherlands or the US. Data were analyzed and used to develop a conceptual framework and an item pool, which was used to develop preliminary scales. Between February 2021 to November 2021, iterative feedback was sought from clinicians and patient participants on the scales and used to refine or develop new scales. The revised scales were pilot-tested using a crowd-sourcing platform between February 2022 and April 2022.

Results: Data from interviews with 84 participants (aged 34 ± 14 years) resulted in a conceptual framework of the GENDER-Q with 13 domains measuring health-related quality of life, sexual, urination, gender practices, voice, hair, face and neck, body, breasts, genital feminization, chest, genital masculinization, and experience of care. Preliminary versions of 44 scales were developed covering most concepts in the conceptual framework. Iterative feedback was obtained from clinician experts (4 to 37 experts per scale; response rate, 67%) and 7-14 patient participants (depending on scale). All scales were refined, and 15 new scales were developed, resulting in 55 scales in the field test version of the GENDER-Q. In total, 601 transgender and gender diverse (TGD) people (aged 25 ± 6 years) participated in the pilot field test and the data were used to make changes to the field test survey.

Conclusion: The GENDER-Q was developed using extensive input from TGD individuals and clinician experts and represents the most comprehensive set of independently functioning scales that are available to date. An international field test of the GENDER-Q was completed in 2024 and the GENDER-Q is available for use in patient care, clinical research and quality improvement efforts.

背景:为了有意义地了解性别平权护理的结果,迫切需要以寻求护理的个人所关心的问题为基础的患者报告结果测量(PROMs)。本研究的目的是开发一种全面的 PROM,用于评估临床实践、研究和质量计划中性别肯定护理的结果(GENDER-Q):方法:采用国际公认的 PROM 开发指南来创建 GENDER-Q 的实地测试版本。从 2018 年 12 月到 2020 年 3 月,我们对正在加拿大、丹麦、荷兰或美国的三级医疗中心或社区内提供性别平权护理的门诊诊所寻求或接受过性别平权护理的 16 岁及以上青年和成人进行了深入访谈。我们对数据进行了分析,并利用这些数据制定了一个概念框架和一个项目库,然后利用该框架和项目库制定了初步量表。2021 年 2 月至 2021 年 11 月期间,临床医生和患者参与者对量表进行了反复反馈,并用于完善或开发新的量表。2022 年 2 月至 2022 年 4 月期间,利用众包平台对修订后的量表进行了试点测试:对 84 名参与者(年龄为 34 ± 14 岁)的访谈数据形成了 GENDER-Q 的概念框架,包括 13 个领域,分别测量与健康相关的生活质量、性、排尿、性别行为、声音、头发、面部和颈部、身体、乳房、生殖器女性化、胸部、生殖器男性化和护理体验。初步制定的 44 个量表涵盖了概念框架中的大多数概念。临床专家(每个量表有 4 至 37 名专家;回复率为 67%)和 7 至 14 名患者参与者(视量表而定)提供了迭代反馈。对所有量表进行了改进,并开发了 15 个新量表,最终形成了 55 个量表的 GENDER-Q 实地测试版本。共有 601 名变性者和性别多元化者(年龄为 25 ± 6 岁)参加了现场测试,并根据测试数据对现场测试调查进行了修改:GENDER-Q 是在广泛听取变性者和临床专家意见的基础上开发出来的,是迄今为止最全面的独立功能量表。GENDER-Q 的国际实地测试已于 2024 年完成,GENDER-Q 可用于患者护理、临床研究和质量改进工作。
{"title":"International study to develop a patient-reported outcome measure to evaluate outcomes of gender-affirming care - the GENDER-Q.","authors":"Manraj N Kaur, Shane D Morrison, Shelby L Kennedy, Tim C van de Grift, Astrid Højgaard, Amalie Lind Jacobsen, Natasha Johnson, Margriet G Mullender, Lotte Poulsen, Thomas Satterwhite, Richard Santucci, John Semple, Charlene Rae, Kinusan Savard, Jens Ahm Sørensen, Danny Young-Afat, Andrea L Pusic, Anne F Klassen","doi":"10.1186/s41687-024-00785-x","DOIUrl":"10.1186/s41687-024-00785-x","url":null,"abstract":"<p><strong>Background: </strong>To meaningfully understand outcomes of gender-affirming care, patient-reported outcome measures (PROMs) that are grounded in what matters to individuals seeking care are urgently needed. The objective of this study was to develop a comprehensive PROM to assess outcomes of gender-affirming care in clinical practice, research, and quality initiatives (the GENDER-Q).</p><p><strong>Methods: </strong>Internationally established guidelines for PROM development were used to create a field test version of the GENDER-Q. In-depth interviews were conducted from December 2018 to March 2020 with youth and adults aged 16 years and older who were seeking or had received gender-affirming care at outpatient clinics providing gender-affirming care located within tertiary care centers or communities in Canada, Denmark, the Netherlands or the US. Data were analyzed and used to develop a conceptual framework and an item pool, which was used to develop preliminary scales. Between February 2021 to November 2021, iterative feedback was sought from clinicians and patient participants on the scales and used to refine or develop new scales. The revised scales were pilot-tested using a crowd-sourcing platform between February 2022 and April 2022.</p><p><strong>Results: </strong>Data from interviews with 84 participants (aged 34 ± 14 years) resulted in a conceptual framework of the GENDER-Q with 13 domains measuring health-related quality of life, sexual, urination, gender practices, voice, hair, face and neck, body, breasts, genital feminization, chest, genital masculinization, and experience of care. Preliminary versions of 44 scales were developed covering most concepts in the conceptual framework. Iterative feedback was obtained from clinician experts (4 to 37 experts per scale; response rate, 67%) and 7-14 patient participants (depending on scale). All scales were refined, and 15 new scales were developed, resulting in 55 scales in the field test version of the GENDER-Q. In total, 601 transgender and gender diverse (TGD) people (aged 25 ± 6 years) participated in the pilot field test and the data were used to make changes to the field test survey.</p><p><strong>Conclusion: </strong>The GENDER-Q was developed using extensive input from TGD individuals and clinician experts and represents the most comprehensive set of independently functioning scales that are available to date. An international field test of the GENDER-Q was completed in 2024 and the GENDER-Q is available for use in patient care, clinical research and quality improvement efforts.</p>","PeriodicalId":36660,"journal":{"name":"Journal of Patient-Reported Outcomes","volume":"8 1","pages":"134"},"PeriodicalIF":2.4,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11576686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How patient-reported outcomes and experience measures (PROMs and PREMs) are implemented in healthcare professional and patient organizations? An environmental scan. 患者报告的结果和体验测量(PROMs 和 PREMs)是如何在医疗专业人员和患者组织中实施的?环境扫描。
IF 2.4 Q2 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-11-15 DOI: 10.1186/s41687-024-00795-9
Véronique Lowry, Vanessa Tremblay-Vaillancourt, Priscilla Beaupré, Marie-Dominique Poirier, Marie-Ève Perron, Jessica Bernier, Anaëlle Morin, Caroline Cormier, Jeannie Haggerty, Sara Ahmed, Magaly Brodeur, Geneviève David, Sylvie Lambert, Maude Laberge, Diana Zidarov, Regina Visca, Thomas G Poder, Hervé Tchala Vignon Zomahoun, Maxime Sasseville, Marie-Eve Poitras

Background: Patient-reported outcome measures (PROMs) and patient-reported experience measures (PREMs) are becoming essential parts of a learning health system, and using these measures is a promising approach for value-based healthcare. However, evidence regarding healthcare professional and patient organizations' knowledge, use and perception of PROMs and PREMs is lacking.

Objectives: The objectives of the study were to: 1- Describe the current knowledge and use of PROMs and PREMs by healthcare professional and patient organizations, 2- Describe the determinants of PROMs and PREMs implementation according to healthcare professional and patient organizations.

Methods: We conducted an environmental scan using semi-structured interviews with representatives from healthcare professional and patient organizations. Interviews were recorded and live coded based on the Franklin framework. We used inductive and deductive thematic analysis to extract information about the main themes addressed during the interview (awareness of PROMs and PREMs, examples of implementation and use of PROMs and PREMs, tools used, vision for future implementation, barriers and facilitators to implementation and the best way to collect PROMs and PREMs data).

Results: 63% of healthcare professional organizations (n = 19) and 41% of patient organizations (n = 9) that were contacted agreed to have a representative interviewed. The representatives from both the healthcare professional and patient organizations acknowledged the importance of assessing patients' experience and outcomes. However, they considered the implementation of PROMs and PREMs tools to be scarce within their organizations, in clinical practice and in the education system. Patient organizations were worried that overuse of PROMs and PREMs could lead to depersonalization of practice. Barriers to implementing PROMs and PREMs included lack of awareness of tools, resistance to change and lack of motivation to complete or explain the questionnaire. Barriers also included factors such as lack of financial, technological and human resources and issues with integration of data and inconsistency of digital platforms.

Conclusions: This environmental scan revealed a lack of awareness of tools by healthcare professional and patient organizations' representatives and limited implementation. Adequate training, technological integration, and demonstration of PROMs and PREMs benefits to foster broader adoption in clinical and organizational settings is dearly needed. Addressing these challenges is essential for enhancing value-based care.

背景:患者报告结果测量法(PROMs)和患者报告体验测量法(PREMs)正成为学习型医疗系统的重要组成部分,使用这些测量法是实现以价值为基础的医疗保健的一种可行方法。然而,有关医疗保健专业人员和患者组织对 PROMs 和 PREMs 的了解、使用和看法的证据还很缺乏:本研究的目的是1- 描述医疗专业人员和患者组织目前对 PROMs 和 PREMs 的了解和使用情况;2- 描述医疗专业人员和患者组织实施 PROMs 和 PREMs 的决定因素:我们采用半结构化访谈的方式对医疗专业人员和患者组织的代表进行了环境扫描。根据富兰克林框架对访谈进行了记录和实时编码。我们采用归纳和演绎主题分析法提取访谈中涉及的主要主题信息(对 PROMs 和 PREMs 的认识、实施和使用 PROMs 和 PREMs 的实例、使用的工具、未来实施的愿景、实施的障碍和促进因素以及收集 PROMs 和 PREMs 数据的最佳方法):63% 的医护专业组织(n = 19)和 41% 的患者组织(n = 9)同意派代表接受采访。医疗专业组织和患者组织的代表都承认评估患者体验和结果的重要性。然而,他们认为在他们的组织、临床实践和教育系统中,PROMs 和 PREMs 工具的实施还很少。患者组织担心,过度使用 PROMs 和 PREMs 可能会导致实践的非人格化。实施 PROMs 和 PREMs 的障碍包括缺乏对工具的认识、抵制变革以及缺乏填写或解释问卷的动力。障碍还包括缺乏资金、技术和人力资源,以及数据整合和数字平台不一致等因素:此次环境扫描显示,医疗保健专业人员和患者组织代表对工具缺乏认识,实施力度有限。我们亟需开展充分的培训、技术整合以及展示 PROMs 和 PREMs 的优势,以促进临床和组织机构更广泛地采用这些工具。应对这些挑战对于加强基于价值的医疗至关重要。
{"title":"How patient-reported outcomes and experience measures (PROMs and PREMs) are implemented in healthcare professional and patient organizations? An environmental scan.","authors":"Véronique Lowry, Vanessa Tremblay-Vaillancourt, Priscilla Beaupré, Marie-Dominique Poirier, Marie-Ève Perron, Jessica Bernier, Anaëlle Morin, Caroline Cormier, Jeannie Haggerty, Sara Ahmed, Magaly Brodeur, Geneviève David, Sylvie Lambert, Maude Laberge, Diana Zidarov, Regina Visca, Thomas G Poder, Hervé Tchala Vignon Zomahoun, Maxime Sasseville, Marie-Eve Poitras","doi":"10.1186/s41687-024-00795-9","DOIUrl":"10.1186/s41687-024-00795-9","url":null,"abstract":"<p><strong>Background: </strong>Patient-reported outcome measures (PROMs) and patient-reported experience measures (PREMs) are becoming essential parts of a learning health system, and using these measures is a promising approach for value-based healthcare. However, evidence regarding healthcare professional and patient organizations' knowledge, use and perception of PROMs and PREMs is lacking.</p><p><strong>Objectives: </strong>The objectives of the study were to: 1- Describe the current knowledge and use of PROMs and PREMs by healthcare professional and patient organizations, 2- Describe the determinants of PROMs and PREMs implementation according to healthcare professional and patient organizations.</p><p><strong>Methods: </strong>We conducted an environmental scan using semi-structured interviews with representatives from healthcare professional and patient organizations. Interviews were recorded and live coded based on the Franklin framework. We used inductive and deductive thematic analysis to extract information about the main themes addressed during the interview (awareness of PROMs and PREMs, examples of implementation and use of PROMs and PREMs, tools used, vision for future implementation, barriers and facilitators to implementation and the best way to collect PROMs and PREMs data).</p><p><strong>Results: </strong>63% of healthcare professional organizations (n = 19) and 41% of patient organizations (n = 9) that were contacted agreed to have a representative interviewed. The representatives from both the healthcare professional and patient organizations acknowledged the importance of assessing patients' experience and outcomes. However, they considered the implementation of PROMs and PREMs tools to be scarce within their organizations, in clinical practice and in the education system. Patient organizations were worried that overuse of PROMs and PREMs could lead to depersonalization of practice. Barriers to implementing PROMs and PREMs included lack of awareness of tools, resistance to change and lack of motivation to complete or explain the questionnaire. Barriers also included factors such as lack of financial, technological and human resources and issues with integration of data and inconsistency of digital platforms.</p><p><strong>Conclusions: </strong>This environmental scan revealed a lack of awareness of tools by healthcare professional and patient organizations' representatives and limited implementation. Adequate training, technological integration, and demonstration of PROMs and PREMs benefits to foster broader adoption in clinical and organizational settings is dearly needed. Addressing these challenges is essential for enhancing value-based care.</p>","PeriodicalId":36660,"journal":{"name":"Journal of Patient-Reported Outcomes","volume":"8 1","pages":"133"},"PeriodicalIF":2.4,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Switching treatment to cipaglucosidase alfa plus miglustat positively affects patient-reported outcome measures in patients with late-onset Pompe disease. 晚发型庞贝病患者改用西帕糖苷酶α加米格鲁司他治疗会对患者报告的疗效产生积极影响。
IF 2.4 Q2 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-11-13 DOI: 10.1186/s41687-024-00805-w
Priya S Kishnani, Barry J Byrne, Kristl G Claeys, Jordi Díaz-Manera, Mazen M Dimachkie, Hani Kushlaf, Tahseen Mozaffar, Mark Roberts, Benedikt Schoser, Noemi Hummel, Agnieszka Kopiec, Fred Holdbrook, Simon Shohet, Antonio Toscano

Background: Late-onset Pompe disease (LOPD), a rare autosomal recessive multisystemic disorder, substantially impacts patients' day-to-day activities, outcomes, and health-related quality of life (HRQoL). The PROPEL trial compared cipaglucosidase alfa plus miglustat (cipa+mig) with alglucosidase alfa plus placebo (alg+pbo) in adult patients with LOPD over 52 weeks and showed improved motor and respiratory function in patients switching treatment from standard-of-care enzyme replacement therapy (ERT) to cipa+mig at baseline. This study evaluated the impact of cipa+mig on patient-reported outcomes (PROs), including HRQoL in ERT-experienced patients, using data from PROPEL.

Methods: PROs evaluated included the Subject's Global Impression of Change (SGIC), Patient-Reported Outcomes Measurement Information System (PROMIS) Physical Function Short Form 20a, PROMIS Fatigue Short Form 8a, Rasch-built Pompe-specific Activity (R-PAct), and European Quality of Life-5 Dimensions 5 Response Levels (EQ-5D-5L). The proportions of responders in the cipa+mig arm and the alg+pbo arm were compared via chi-squared or Fisher's exact test (patient-level responder analysis), and least squares (LS) mean differences were calculated for change from baseline at Week 52 of the PRO measures (group-level analysis).

Results: At Week 52, patient-level SGIC responder and group-level SGIC analyses favored cipa+mig compared with alg+pbo across all SGIC domains (e.g. 90 vs. 59% responders in the cipa+mig vs. the alg+pbo group for SGIC ability to move around; P = 0.0005; and LS mean difference 0.385; P = 0.02). Similarly, PROMIS Physical Function and Fatigue domains numerically favored cipa+mig in both analyses (e.g. 50 vs. 40% responders in the cipa+mig vs. alg+pbo arm for PROMIS Physical Function; P = 0.37; and LS mean difference 3.1; P = 0.11). R-PAct for both treatment groups was similar in the patient-level responder analysis, but numerically favored alg+pbo in the group-level analysis (35% responders in both arms; P = 0.95; and LS mean difference -0.8; P = 0.48). Self-care, usual activities, and depression/anxiety domains of EQ-5D-5L numerically favored cipa+mig in both analyses (e.g. 20 vs. 12% responders in the cipa+mig vs. alg+pbo arm for EQ-5D-5L self-care; P = 0.54; and LS mean difference -0.108; P = 0.52).

Conclusions: Overall, switching treatment from alglucosidase alfa to cipa+mig positively impacted PRO measurements during the double-blind period of PROPEL.

Trial registration: NCT03729362; Registration date: November 1, 2018; https://clinicaltrials.gov/study/NCT03729362.

背景:晚发型庞贝氏症(LOPD)是一种罕见的常染色体隐性多系统疾病,严重影响患者的日常活动、治疗效果和健康相关生活质量(HRQoL)。PROPEL试验比较了西帕糖苷酶α加米格鲁司他(cipa+mig)与阿糖苷酶α加安慰剂(alg+pbo)对成年LOPD患者52周的治疗效果,结果显示,基线时从标准酶替代疗法(ERT)转为西帕+mig治疗的患者运动和呼吸功能均有所改善。本研究利用 PROPEL 的数据评估了 cipa+mig 对患者报告结果(PROs)的影响,包括 ERT 经验患者的 HRQoL:评估的患者报告结果包括受试者总体变化印象 (SGIC)、患者报告结果测量信息系统 (PROMIS) 身体功能简表 20a、PROMIS 疲劳简表 8a、Rasch-built Pompe 特异性活动 (R-PAct) 和欧洲生活质量-5 维度 5 反应水平 (EQ-5D-5L)。通过卡方检验或费雪精确检验比较了 cipa+mig 治疗组和 alg+pbo 治疗组中应答者的比例(患者水平应答者分析),并计算了第 52 周 PRO 指标与基线相比变化的最小二乘法(LS)均差(组水平分析):结果:第52周时,患者层面的SGIC应答者分析和组层面的SGIC分析显示,在所有SGIC领域,cipa+mig均优于alg+pbo(例如,在SGIC活动能力方面,cipa+mig组应答者为90%,alg+pbo组为59%;P = 0.0005;LS均差为0.385;P = 0.02)。同样,在两项分析中,PROMIS 体力功能和疲劳域在数字上更倾向于 cipa+mig 组(例如,在 PROMIS 体力功能方面,cipa+mig 组与 alg+pbo 组的应答率分别为 50% 和 40%;P = 0.37;LS 平均差为 3.1;P = 0.11)。在患者层面的应答者分析中,两个治疗组的 R-PAct 相似,但在组层面的分析中,从数字上看,alg+pbo 更受青睐(两组均有 35% 的应答者;P = 0.95;LS 平均差异 -0.8;P = 0.48)。在两项分析中,EQ-5D-5L的自我护理、日常活动和抑郁/焦虑领域在数字上更倾向于cipa+mig(例如,在EQ-5D-5L自我护理方面,cipa+mig组与alg+pbo组的应答者比例分别为20%和12%;P = 0.54;LS平均差为-0.108;P = 0.52):总体而言,在PROPEL双盲期间,从阿糖苷酶α治疗转为西帕+米格治疗对PRO测量结果有积极影响:NCT03729362;注册日期:2018年11月1日;https://clinicaltrials.gov/study/NCT03729362。
{"title":"Switching treatment to cipaglucosidase alfa plus miglustat positively affects patient-reported outcome measures in patients with late-onset Pompe disease.","authors":"Priya S Kishnani, Barry J Byrne, Kristl G Claeys, Jordi Díaz-Manera, Mazen M Dimachkie, Hani Kushlaf, Tahseen Mozaffar, Mark Roberts, Benedikt Schoser, Noemi Hummel, Agnieszka Kopiec, Fred Holdbrook, Simon Shohet, Antonio Toscano","doi":"10.1186/s41687-024-00805-w","DOIUrl":"10.1186/s41687-024-00805-w","url":null,"abstract":"<p><strong>Background: </strong>Late-onset Pompe disease (LOPD), a rare autosomal recessive multisystemic disorder, substantially impacts patients' day-to-day activities, outcomes, and health-related quality of life (HRQoL). The PROPEL trial compared cipaglucosidase alfa plus miglustat (cipa+mig) with alglucosidase alfa plus placebo (alg+pbo) in adult patients with LOPD over 52 weeks and showed improved motor and respiratory function in patients switching treatment from standard-of-care enzyme replacement therapy (ERT) to cipa+mig at baseline. This study evaluated the impact of cipa+mig on patient-reported outcomes (PROs), including HRQoL in ERT-experienced patients, using data from PROPEL.</p><p><strong>Methods: </strong>PROs evaluated included the Subject's Global Impression of Change (SGIC), Patient-Reported Outcomes Measurement Information System (PROMIS) Physical Function Short Form 20a, PROMIS Fatigue Short Form 8a, Rasch-built Pompe-specific Activity (R-PAct), and European Quality of Life-5 Dimensions 5 Response Levels (EQ-5D-5L). The proportions of responders in the cipa+mig arm and the alg+pbo arm were compared via chi-squared or Fisher's exact test (patient-level responder analysis), and least squares (LS) mean differences were calculated for change from baseline at Week 52 of the PRO measures (group-level analysis).</p><p><strong>Results: </strong>At Week 52, patient-level SGIC responder and group-level SGIC analyses favored cipa+mig compared with alg+pbo across all SGIC domains (e.g. 90 vs. 59% responders in the cipa+mig vs. the alg+pbo group for SGIC ability to move around; P = 0.0005; and LS mean difference 0.385; P = 0.02). Similarly, PROMIS Physical Function and Fatigue domains numerically favored cipa+mig in both analyses (e.g. 50 vs. 40% responders in the cipa+mig vs. alg+pbo arm for PROMIS Physical Function; P = 0.37; and LS mean difference 3.1; P = 0.11). R-PAct for both treatment groups was similar in the patient-level responder analysis, but numerically favored alg+pbo in the group-level analysis (35% responders in both arms; P = 0.95; and LS mean difference -0.8; P = 0.48). Self-care, usual activities, and depression/anxiety domains of EQ-5D-5L numerically favored cipa+mig in both analyses (e.g. 20 vs. 12% responders in the cipa+mig vs. alg+pbo arm for EQ-5D-5L self-care; P = 0.54; and LS mean difference -0.108; P = 0.52).</p><p><strong>Conclusions: </strong>Overall, switching treatment from alglucosidase alfa to cipa+mig positively impacted PRO measurements during the double-blind period of PROPEL.</p><p><strong>Trial registration: </strong>NCT03729362; Registration date: November 1, 2018; https://clinicaltrials.gov/study/NCT03729362.</p>","PeriodicalId":36660,"journal":{"name":"Journal of Patient-Reported Outcomes","volume":"8 1","pages":"132"},"PeriodicalIF":2.4,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11561219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patient perception of bowel urgency and remission in moderately to severely active Crohn's disease or ulcerative colitis: a qualitative study. 中度至重度活动性克罗恩病或溃疡性结肠炎患者对肠道紧迫感和缓解的看法:一项定性研究。
IF 2.4 Q2 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-11-12 DOI: 10.1186/s41687-024-00800-1
Theresa Hunter Gibble, Larissa Stassek, Gale Harding, Marissa Stefan, Tsion Fikre, Alison Potts Bleakman, Richard Moses, Marla Dubinsky

Background: Bowel urgency, the sudden and immediate need to have a bowel movement, is common in patients with ulcerative colitis (UC) and Crohn's disease (CD). While its impact in UC is well established, less is known about its importance in CD. Further, what level of bowel urgency control patients with UC or CD would consider to be acceptable or in remission has not been established. This qualitative study aimed to understand perceptions of bowel urgency and remission in these patients.

Methods: Semi-structured combined concept elicitation and cognitive interviews were conducted to explore how adults with moderate-to-severe UC or CD and current or recent bowel urgency think about the concept of bowel urgency and its remission. The Urgency Numeric Rating Scale (UNRS) was used to examine different levels of bowel urgency severity and to investigate what level of bowel urgency patients would consider as representing remission.

Results: Forty adults (n = 19 UC, n = 21 CD) recruited from six US sites completed the study. Sociodemographic and clinical characteristics were similar in both groups. Both groups reported impacts of bowel urgency on physical, social, professional, and emotional aspects of their lives. Most participants (n = 15 UC, n = 18 CD) reported having experienced one or more incidents of urgency-related fecal incontinence. Most participants considered remission to be a state with a normal or reduced number of bowel movements and no or less frequent bowel urgency, and they noted that remission would increase their ability to engage in daily activities without fear of fecal incontinence. Participants were able to map different levels of severity of bowel urgency to UNRS score ranges (scale: 0-10), and they indicated that a mean UNRS score of 5 (UC) or 4 (CD) would be the highest point on the NRS at which they would still consider their bowel urgency to be in remission.

Conclusions: Bowel urgency is an important issue for patients with either moderate-to-severe UC or CD, and its remission would improve their lives. Further, these patients may still consider bowel urgency to be in remission even at UNRS scores as high as 4 or 5.

背景:排便急迫症是溃疡性结肠炎(UC)和克罗恩病(CD)患者中常见的症状,即突然需要立即排便。急迫排便对溃疡性结肠炎的影响已得到公认,但对其在克罗恩病中的重要性却知之甚少。此外,UC 或 CD 患者认为何种程度的肠紧迫感控制是可接受的或处于缓解期,也尚未确定。这项定性研究旨在了解这些患者对肠道紧迫感和缓解的看法:采用半结构式概念诱导和认知访谈相结合的方法,探讨患有中重度 UC 或 CD 且目前或近期有肠紧迫感的成年人如何看待肠紧迫感及其缓解的概念。研究使用肠紧迫性数字评定量表(UNRS)来检查不同程度的肠紧迫性严重性,并调查患者认为何种程度的肠紧迫性代表缓解:从美国六个地点招募的 40 名成人(n = 19 UC,n = 21 CD)完成了这项研究。两组患者的社会人口学特征和临床特征相似。两组人都报告了肠紧迫症对他们生活中的身体、社交、职业和情感方面的影响。大多数参与者(n = 15 UC,n = 18 CD)表示曾经历过一次或多次与肠急相关的大便失禁。大多数参与者认为,病情缓解是指排便次数正常或减少,没有或较少出现急迫性排便,他们指出,病情缓解将提高他们从事日常活动的能力,而不必担心大便失禁。参与者能够将不同严重程度的肠紧迫感映射到 UNRS 评分范围(0-10 分),他们表示平均 UNRS 评分为 5 分(UC)或 4 分(CD)是他们认为肠紧迫感缓解的 NRS 最高分:结论:对于中重度 UC 或 CD 患者来说,肠紧迫感是一个重要问题,缓解肠紧迫感将改善他们的生活。此外,即使 UNRS 评分高达 4 分或 5 分,这些患者仍可能认为肠紧迫感得到了缓解。
{"title":"Patient perception of bowel urgency and remission in moderately to severely active Crohn's disease or ulcerative colitis: a qualitative study.","authors":"Theresa Hunter Gibble, Larissa Stassek, Gale Harding, Marissa Stefan, Tsion Fikre, Alison Potts Bleakman, Richard Moses, Marla Dubinsky","doi":"10.1186/s41687-024-00800-1","DOIUrl":"10.1186/s41687-024-00800-1","url":null,"abstract":"<p><strong>Background: </strong>Bowel urgency, the sudden and immediate need to have a bowel movement, is common in patients with ulcerative colitis (UC) and Crohn's disease (CD). While its impact in UC is well established, less is known about its importance in CD. Further, what level of bowel urgency control patients with UC or CD would consider to be acceptable or in remission has not been established. This qualitative study aimed to understand perceptions of bowel urgency and remission in these patients.</p><p><strong>Methods: </strong>Semi-structured combined concept elicitation and cognitive interviews were conducted to explore how adults with moderate-to-severe UC or CD and current or recent bowel urgency think about the concept of bowel urgency and its remission. The Urgency Numeric Rating Scale (UNRS) was used to examine different levels of bowel urgency severity and to investigate what level of bowel urgency patients would consider as representing remission.</p><p><strong>Results: </strong>Forty adults (n = 19 UC, n = 21 CD) recruited from six US sites completed the study. Sociodemographic and clinical characteristics were similar in both groups. Both groups reported impacts of bowel urgency on physical, social, professional, and emotional aspects of their lives. Most participants (n = 15 UC, n = 18 CD) reported having experienced one or more incidents of urgency-related fecal incontinence. Most participants considered remission to be a state with a normal or reduced number of bowel movements and no or less frequent bowel urgency, and they noted that remission would increase their ability to engage in daily activities without fear of fecal incontinence. Participants were able to map different levels of severity of bowel urgency to UNRS score ranges (scale: 0-10), and they indicated that a mean UNRS score of 5 (UC) or 4 (CD) would be the highest point on the NRS at which they would still consider their bowel urgency to be in remission.</p><p><strong>Conclusions: </strong>Bowel urgency is an important issue for patients with either moderate-to-severe UC or CD, and its remission would improve their lives. Further, these patients may still consider bowel urgency to be in remission even at UNRS scores as high as 4 or 5.</p>","PeriodicalId":36660,"journal":{"name":"Journal of Patient-Reported Outcomes","volume":"8 1","pages":"130"},"PeriodicalIF":2.4,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11557785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early insights from the routine use of patient reported outcome measures in elective hip and knee arthroplasty at a public teaching hospital in South Australia. 南澳大利亚州一家公立教学医院在择期髋关节和膝关节置换术中常规使用患者报告结果指标的早期启示。
IF 2.4 Q2 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-11-12 DOI: 10.1186/s41687-024-00807-8
Samuel P Goldsmith, Paul N Karayiannis, Louisa M Edwards, Barbara Toson, Freeda D'Mello, Emma Jackman, Christopher John Wilson, Anthony Samson

Introduction: For advanced osteoarthritis of the knee and hip, the most clinically effective treatment remains total-knee arthroplasty (TKA) and total-hip arthroplasty (THA). Success of these surgeries have traditionally been appraised by economic and volume-based measures. There has been a shift towards the use of patient reported outcome measures (PROMs) to quantify success and guide treatment. The present study provides analysis of three PROMS which have been validated for use in orthopaedic settings; the Oxford Knee Score (OKS), Oxford Hip Score (OHS), Forgotten Joint Score (FJS), and the EuroQol-Visual Analogue Scale (EQ-VAS) - a non-disease specific measure of health. PROMs were completed pre-operatively, 6-weeks, and 1-year after elective TKA and THA undertaken in 2018 in a public teaching hospital in South Australia. Post-operative satisfaction/dissatisfaction was measured using a 5-point Likert scale and was collected at the same 6-week and 1-year points.

Results: PROMs were collected from 285 eligible elective knee-arthroplasty, and 205 elective hip-arthroplasty patients. There was significant average improvement, greater than minimal clinical important differences between pre-operative and 1-year post-operative scores for all three PROMs tools. Inter-PROM correlation was strongest between FJS and OKS at 1-year post TKA (rs = 0.722), and between FJS and OHS in post-THA at the same interval (rs = 0.609). TKA patients with higher pre-surgical 10-year mortality were weakly associated with lower pre-operative OKS score (rs = 0.169). BMI was weakly negatively associated with pre-operative and 6-week post-operative EQ-VAS scores (rs = -0.291 and rs = -0.149 respectively). Post-TKA satisfaction was 77.2% at 1-year, and THA 88.5% at the same interval.

Conclusion: This study provides an early insight from the use of the OKS, OHS, the EQ-VAS and the FJS as PROMs in primary TKA and THA at our centre. All PROMs demonstrate significant increase (improvement) at both 6-week and 1-year post-operative intervals, relative to pre-operative scores. The FJS demonstrated good sensitivity. Pre-existing co-morbidities do not appear to have any significant relation with post-operative PROMs collected in this study.

导言:对于晚期膝关节和髋关节骨性关节炎,临床上最有效的治疗方法仍然是全膝关节置换术(TKA)和全髋关节置换术(THA)。传统上,这些手术的成功与否是通过经济和数量来评估的。现在已开始转向使用患者报告结果指标(PROMs)来量化成功率和指导治疗。本研究分析了三项经过验证可用于骨科领域的 PROMS:牛津膝关节评分 (OKS)、牛津髋关节评分 (OHS)、遗忘关节评分 (FJS),以及 EuroQol 视觉模拟量表 (EQ-VAS)--一种非特定疾病的健康测量方法。2018年在南澳大利亚州的一家公立教学医院进行了选择性TKA和THA手术,分别在术前、术后6周和术后1年完成了PROM。术后满意度/不满意度采用5点李克特量表进行测量,并在同样的6周和1年时间点收集:从285名符合条件的择期膝关节置换术患者和205名择期髋关节置换术患者中收集了PROMs。在所有三种 PROMs 工具中,术前评分和术后 1 年评分的平均改善幅度都很大,且临床意义差异都大于最小值。TKA 术后 1 年的 FJS 和 OKS 之间的 PROM 间相关性最强(rs = 0.722),THA 术后 1 年的 FJS 和 OHS 之间的相关性也最强(rs = 0.609)。手术前 10 年死亡率较高的 TKA 患者与术前较低的 OKS 评分呈弱相关(rs = 0.169)。体重指数与术前和术后 6 周的 EQ-VAS 评分呈弱负相关(rs = -0.291 和 rs = -0.149)。TKA术后1年的满意度为77.2%,THA术后1年的满意度为88.5%:本研究提供了在本中心使用 OKS、OHS、EQ-VAS 和 FJS 作为初级 TKA 和 THA 的 PROMs 的早期见解。与术前评分相比,所有 PROMs 在术后 6 周和 1 年的间隔时间内都有明显的增加(改善)。FJS显示出良好的灵敏度。本研究中收集的术前并发症与术后 PROMs 似乎没有明显关系。
{"title":"Early insights from the routine use of patient reported outcome measures in elective hip and knee arthroplasty at a public teaching hospital in South Australia.","authors":"Samuel P Goldsmith, Paul N Karayiannis, Louisa M Edwards, Barbara Toson, Freeda D'Mello, Emma Jackman, Christopher John Wilson, Anthony Samson","doi":"10.1186/s41687-024-00807-8","DOIUrl":"10.1186/s41687-024-00807-8","url":null,"abstract":"<p><strong>Introduction: </strong>For advanced osteoarthritis of the knee and hip, the most clinically effective treatment remains total-knee arthroplasty (TKA) and total-hip arthroplasty (THA). Success of these surgeries have traditionally been appraised by economic and volume-based measures. There has been a shift towards the use of patient reported outcome measures (PROMs) to quantify success and guide treatment. The present study provides analysis of three PROMS which have been validated for use in orthopaedic settings; the Oxford Knee Score (OKS), Oxford Hip Score (OHS), Forgotten Joint Score (FJS), and the EuroQol-Visual Analogue Scale (EQ-VAS) - a non-disease specific measure of health. PROMs were completed pre-operatively, 6-weeks, and 1-year after elective TKA and THA undertaken in 2018 in a public teaching hospital in South Australia. Post-operative satisfaction/dissatisfaction was measured using a 5-point Likert scale and was collected at the same 6-week and 1-year points.</p><p><strong>Results: </strong>PROMs were collected from 285 eligible elective knee-arthroplasty, and 205 elective hip-arthroplasty patients. There was significant average improvement, greater than minimal clinical important differences between pre-operative and 1-year post-operative scores for all three PROMs tools. Inter-PROM correlation was strongest between FJS and OKS at 1-year post TKA (r<sub>s</sub> = 0.722), and between FJS and OHS in post-THA at the same interval (r<sub>s</sub> = 0.609). TKA patients with higher pre-surgical 10-year mortality were weakly associated with lower pre-operative OKS score (r<sub>s</sub> = 0.169). BMI was weakly negatively associated with pre-operative and 6-week post-operative EQ-VAS scores (r<sub>s</sub> = -0.291 and r<sub>s</sub> = -0.149 respectively). Post-TKA satisfaction was 77.2% at 1-year, and THA 88.5% at the same interval.</p><p><strong>Conclusion: </strong>This study provides an early insight from the use of the OKS, OHS, the EQ-VAS and the FJS as PROMs in primary TKA and THA at our centre. All PROMs demonstrate significant increase (improvement) at both 6-week and 1-year post-operative intervals, relative to pre-operative scores. The FJS demonstrated good sensitivity. Pre-existing co-morbidities do not appear to have any significant relation with post-operative PROMs collected in this study.</p>","PeriodicalId":36660,"journal":{"name":"Journal of Patient-Reported Outcomes","volume":"8 1","pages":"131"},"PeriodicalIF":2.4,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11557799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment decision-making factors among patients with cervical myelopathy: a discrete-choice experiment. 颈椎病患者的治疗决策因素:离散选择实验。
IF 2.4 Q2 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-11-11 DOI: 10.1186/s41687-024-00810-z
Mohamed Sarraj, Meerab Majeed, Mohammad Zarrabian, Jason Busse, Mohit Bhandari, Daipayan Guha, Markian Pahuta

Background: Degenerative Cervical Myelopathy is a debilitating condition and current recommendations encourage shared decision-making between surgeons and patients. However, there is limited data on patients' values and preferences for surgical decision making. This study aimed to quantify and compare the relative importance of neurologic function, risk of future surgery, and complications to patients with cervical stenosis.

Methods: Patients with cervical stenosis presenting for surgical evaluation, or post-operative cervical decompression patients, were recruited to participate. Demographic information including modified Japanese Orthopedic Association (mJOA) score, type of surgery, and complications were recorded and anonymized to study ID. Patients then completed an online discrete-choice experiment survey. In a series of 10 questions, respondents chose between two hypothetical health states defined in terms of five attributes, or "decision factors": (i) upper extremity neurologic function, (ii) lower extremity neurologic function, (iii) risk of cervical spine surgery, (iv) dysphagia, and (v) C5 palsy. Participants were asked to choose which 'life' they preferred, and a regression model was used to quantify the importance of each decision factor.

Results: We report three key findings that can aid clinicians in shared decision-making conversations: (i) all patients regard lower extremity neurologic function as the most important decision factor, (ii) dysphagia, a complication, and upper extremity neurologic function are equally important, and (iii) patients who have undergone surgery weigh neurologic function as less important, and complications as more important than patients who have not undergone surgery.

Conclusions: Patient preferences for management of degenerative cervical myelopathy are influenced by several considerations including the experience of surgery itself. Communication of benefits and harms associated with surgical and conservative care can optimize shared decision making. Further research should be conducted to evaluate for decisional regret and the impact of complications to inform treatment conversations.

背景:退行性颈椎病是一种使人衰弱的疾病,目前的建议鼓励外科医生和患者共同决策。然而,有关患者对手术决策的价值和偏好的数据却很有限。本研究旨在量化和比较神经功能、未来手术风险和并发症对颈椎管狭窄患者的相对重要性:方法:招募前来接受手术评估的颈椎管狭窄患者或颈椎减压术后患者参与研究。记录人口统计学信息,包括修改后的日本骨科协会(mJOA)评分、手术类型和并发症,并对研究 ID 进行匿名处理。然后,患者完成了一项在线离散选择实验调查。在一系列共 10 个问题中,受访者在两种假设的健康状态中做出选择,这两种健康状态是根据以下五个属性或 "决策因素 "定义的:(i) 上肢神经功能,(ii) 下肢神经功能,(iii) 颈椎手术风险,(iv) 吞咽困难,以及 (v) C5 麻痹。我们要求参与者选择他们更喜欢的 "生活",并使用回归模型来量化每个决策因素的重要性:我们报告了可以帮助临床医生进行共同决策对话的三项重要发现:(i) 所有患者都认为下肢神经功能是最重要的决策因素;(ii) 吞咽困难(一种并发症)和上肢神经功能同等重要;(iii) 与未接受手术的患者相比,接受过手术的患者认为神经功能不那么重要,而并发症则更重要:结论:患者对退行性颈椎脊髓病治疗的偏好受多种因素的影响,包括手术本身的经历。就手术和保守治疗的利弊进行沟通,可以优化共同决策。应开展进一步的研究,评估决策后悔和并发症的影响,为治疗对话提供信息。
{"title":"Treatment decision-making factors among patients with cervical myelopathy: a discrete-choice experiment.","authors":"Mohamed Sarraj, Meerab Majeed, Mohammad Zarrabian, Jason Busse, Mohit Bhandari, Daipayan Guha, Markian Pahuta","doi":"10.1186/s41687-024-00810-z","DOIUrl":"10.1186/s41687-024-00810-z","url":null,"abstract":"<p><strong>Background: </strong>Degenerative Cervical Myelopathy is a debilitating condition and current recommendations encourage shared decision-making between surgeons and patients. However, there is limited data on patients' values and preferences for surgical decision making. This study aimed to quantify and compare the relative importance of neurologic function, risk of future surgery, and complications to patients with cervical stenosis.</p><p><strong>Methods: </strong>Patients with cervical stenosis presenting for surgical evaluation, or post-operative cervical decompression patients, were recruited to participate. Demographic information including modified Japanese Orthopedic Association (mJOA) score, type of surgery, and complications were recorded and anonymized to study ID. Patients then completed an online discrete-choice experiment survey. In a series of 10 questions, respondents chose between two hypothetical health states defined in terms of five attributes, or \"decision factors\": (i) upper extremity neurologic function, (ii) lower extremity neurologic function, (iii) risk of cervical spine surgery, (iv) dysphagia, and (v) C5 palsy. Participants were asked to choose which 'life' they preferred, and a regression model was used to quantify the importance of each decision factor.</p><p><strong>Results: </strong>We report three key findings that can aid clinicians in shared decision-making conversations: (i) all patients regard lower extremity neurologic function as the most important decision factor, (ii) dysphagia, a complication, and upper extremity neurologic function are equally important, and (iii) patients who have undergone surgery weigh neurologic function as less important, and complications as more important than patients who have not undergone surgery.</p><p><strong>Conclusions: </strong>Patient preferences for management of degenerative cervical myelopathy are influenced by several considerations including the experience of surgery itself. Communication of benefits and harms associated with surgical and conservative care can optimize shared decision making. Further research should be conducted to evaluate for decisional regret and the impact of complications to inform treatment conversations.</p>","PeriodicalId":36660,"journal":{"name":"Journal of Patient-Reported Outcomes","volume":"8 1","pages":"129"},"PeriodicalIF":2.4,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experience of Service Questionnaire (ESQ) in children and adolescents: factor structure, reliability, validity, item parameters and interpretability of the parent version for practical use in Greece. 儿童和青少年服务体验问卷(ESQ):希腊实际使用的家长版本的因素结构、可靠性、有效性、项目参数和可解释性。
IF 2.4 Q2 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-11-08 DOI: 10.1186/s41687-024-00798-6
Konstantinos Kotsis, Andromachi Mitropoulou, Alexandra Tzotzi, Lauro Estivalete Marchionatti, Mauricio Scopel Hoffmann, Julia Luiza Schafer, Caio B Casella, André Simioni, Katerina Papanikolaou, Maria Basta, Aspasia Serdari, Anastasia Koumoula, Giovanni Abrahão Salum

Background: Health systems need tools to assess patient's experience of service, but existing tools lack reliability and validity assessment. Our aim is to investigate the factor structure, reliability, validity, item parameters and interpretability of the parent version of the Experience of Service Questionnaire (ESQ) for practical use in Greece.

Methods: A total of 265 caregivers that were using mental health services in Greece participated in this study as part of the Nationwide cross-sectional survey from the Child and Adolescent Mental Health Initiative (CAMHI). Confirmatory Factor Analysis was used to test factor structure. Reliability of all models were measured with omega coefficients. Tobit regression analysis was used to test for convergent and discriminant validity with specifically designed questions. Item parameters were assessed via Item Response Theory. Interpretability was assessed by means of IRT-based scores.

Results: We found that ESQ is best represented and scored as a unidimensional construct, given potential subscales would not have enough reliability apart from a general factor. Convergent and discriminant validity was demonstrated, as caregivers who perceived that their child benefited from the received mental health care had 6.50 higher summed scores (SMD = 1.14, p < 0.001); while those who believed that their child needed additional help had 5.08 lower summed scores on the ESQ (SMD = -0.89, p < 0.001). Average z-scores provided five meaningful categories of services, in terms of user satisfaction, compared to the national average.

Conclusions: Our study presents evidence for the reliability and validity of the ESQ and provides recommendations for its practical use in Greece. ESQ can be used to measure experience of service and might help drive improvements in service delivery in the Greek mental health sector.

背景:医疗系统需要评估患者服务体验的工具,但现有工具缺乏可靠性和有效性评估。我们的目的是调查服务体验问卷(ESQ)母版的因子结构、信度、效度、项目参数和可解释性,以便在希腊实际使用:共有 265 名在希腊使用心理健康服务的照顾者参与了这项研究,这是儿童和青少年心理健康倡议(CAMHI)全国横断面调查的一部分。研究采用了确认性因子分析来检验因子结构。所有模型的可靠性均通过欧米茄系数进行测量。采用托比特回归分析法对专门设计的问题进行收敛性和区分性有效性测试。项目参数通过项目反应理论进行评估。通过基于 IRT 的分数对可解释性进行了评估:结果:我们发现,ESQ最好作为一个单维结构来表示和计分,因为除了一个总体因子外,潜在的子量表没有足够的可靠性。研究结果表明,认为其子女受益于所接受的心理健康护理的护理人员的总分比认为其子女受益于所接受的心理健康护理的护理人员的总分高出 6.50(SMD = 1.14,p 结论:我们的研究为 ESQ 的可靠性和判别性提供了证据:我们的研究为 ESQ 的可靠性和有效性提供了证据,并为 ESQ 在希腊的实际应用提供了建议。ESQ 可用于测量服务体验,并可能有助于推动希腊精神卫生部门改善服务。
{"title":"Experience of Service Questionnaire (ESQ) in children and adolescents: factor structure, reliability, validity, item parameters and interpretability of the parent version for practical use in Greece.","authors":"Konstantinos Kotsis, Andromachi Mitropoulou, Alexandra Tzotzi, Lauro Estivalete Marchionatti, Mauricio Scopel Hoffmann, Julia Luiza Schafer, Caio B Casella, André Simioni, Katerina Papanikolaou, Maria Basta, Aspasia Serdari, Anastasia Koumoula, Giovanni Abrahão Salum","doi":"10.1186/s41687-024-00798-6","DOIUrl":"10.1186/s41687-024-00798-6","url":null,"abstract":"<p><strong>Background: </strong>Health systems need tools to assess patient's experience of service, but existing tools lack reliability and validity assessment. Our aim is to investigate the factor structure, reliability, validity, item parameters and interpretability of the parent version of the Experience of Service Questionnaire (ESQ) for practical use in Greece.</p><p><strong>Methods: </strong>A total of 265 caregivers that were using mental health services in Greece participated in this study as part of the Nationwide cross-sectional survey from the Child and Adolescent Mental Health Initiative (CAMHI). Confirmatory Factor Analysis was used to test factor structure. Reliability of all models were measured with omega coefficients. Tobit regression analysis was used to test for convergent and discriminant validity with specifically designed questions. Item parameters were assessed via Item Response Theory. Interpretability was assessed by means of IRT-based scores.</p><p><strong>Results: </strong>We found that ESQ is best represented and scored as a unidimensional construct, given potential subscales would not have enough reliability apart from a general factor. Convergent and discriminant validity was demonstrated, as caregivers who perceived that their child benefited from the received mental health care had 6.50 higher summed scores (SMD = 1.14, p < 0.001); while those who believed that their child needed additional help had 5.08 lower summed scores on the ESQ (SMD = -0.89, p < 0.001). Average z-scores provided five meaningful categories of services, in terms of user satisfaction, compared to the national average.</p><p><strong>Conclusions: </strong>Our study presents evidence for the reliability and validity of the ESQ and provides recommendations for its practical use in Greece. ESQ can be used to measure experience of service and might help drive improvements in service delivery in the Greek mental health sector.</p>","PeriodicalId":36660,"journal":{"name":"Journal of Patient-Reported Outcomes","volume":"8 1","pages":"128"},"PeriodicalIF":2.4,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11549257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of Patient-Reported Outcomes
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1