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Talus Fractures in Snowboarders: A Case Series 滑雪板运动员距骨骨折:一个病例系列
Q4 Medicine Pub Date : 2022-05-26 DOI: 10.3390/osteology2020012
N. M. Luger, C. Pascual-Garrido, Andrew Haus, Britta L. Swanson, K. Swanson
Fractures of the lateral process of the talus have been associated with snowboarding, so much so that they have earned the nickname “snowboarder’s ankle”; these typically occur with relatively low-energy injuries when compared with fractures of the talar head, neck, and body. We have observed that snowboarding portends a higher risk of talus fractures when compared with skiing and can include higher energy injury patterns. This study describes a series of talar head, neck, and body fractures caused by snowboarding, their treatment, and outcomes. A retrospective chart review was performed on all surgical cases collected from 2007 to 2012 to include talar head, neck, body, or lateral process fractures sustained while snowboarding. Radiographs were reviewed and the fractures were characterized. Questionnaires, including the Foot and Ankle Disability Index (FADI), were mailed to the patients. The pre-operative reports, surgical treatments, and outcomes were evaluated. Nine patients were identified with fractures of the talus caused by a snowboarding injury. One patient sustained an isolated talar head fracture, three sustained isolated talar neck fractures, one patient had an isolated talar body fracture, and two patients had isolated lateral process fractures. Two patients had a combination of talar injuries. At 2.5 years mean follow-up (range 6 months to 5 years), none of the patients developed avascular necrosis, nonunion/malunion, or required subsequent surgery. FADI scores indicated good to excellent results post-operatively.
距骨外侧突骨折与单板滑雪有关,因此被称为“单板运动员的脚踝”;与距骨头、颈部和身体骨折相比,这些损伤通常发生在相对低能量的损伤中。我们观察到,与滑雪相比,单板滑雪预示着更高的距骨骨折风险,并且可能包括更高的能量损伤模式。本研究描述了一系列由单板滑雪引起的距骨、头部、颈部和身体骨折,及其治疗和结果。回顾性分析2007年至2012年收集的所有手术病例,包括滑雪时发生的距骨头、颈部、身体或侧突骨折。检查x线片并确定骨折特征。问卷,包括足部和踝关节残疾指数(FADI),邮寄给患者。评估术前报告、手术治疗和结果。9名患者被确定为由滑雪板损伤引起的距骨骨折。1例孤立性距骨头骨折,3例孤立性距骨颈骨折,1例孤立性距骨体骨折,2例孤立性外侧突骨折。两名患者同时有距骨损伤。在平均随访2.5年(6个月至5年),没有患者出现无血管坏死、不愈合/不愈合或需要后续手术。FADI评分显示术后效果良好至优异。
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引用次数: 1
Impact of Resilience on Patient Reported Outcome of First Metatarsophalangeal Arthrodesis 恢复力对首次跖趾关节融合术患者报告结果的影响
Q4 Medicine Pub Date : 2022-05-19 DOI: 10.3390/osteology2020010
Nicholas A. Andrews, Sterling Tran, S. Young, Jared R. Halstrom, Jessyca L. Ray, Zachary L. Littlefield, G. McGwin, A. Agarwal, Ashish Shah
Resilience is a dynamic construct defined as the ability to recover from stress. There is no literature examining the impact of resilience on outcomes following foot and ankle surgery. Retrospective analysis of patients who underwent first MTP arthrodesis from September 2011 to May 2020 were reviewed for patient characteristics and union status. PROMIS Physical Function (PF), Pain Interference (PI), Depression (D), and Foot Function Index (FFI) were collected. Resilience was measured using the Brief Resilience Scale. A multivariable linear regression analysis examining the impact of resilience on patient reported was conducted. At an average of 3.4 years postoperatively, resilience was found to independently affect patient reported outcomes across all instruments, except the FFI pain subscale. In the first study examining the impact of resilience following foot and ankle surgery, we found that resilience has an independent positive effect on overall physical function, disability, pain, and mental health following MTP arthrodesis. Preoperative resilience scores could be used to predict postoperative functional outcomes following MTP arthrodesis and guide postoperative rehabilitation. These findings help establish the role of early positive psychosocial characteristics within orthopaedic foot and ankle population.
弹性是一种动态结构,被定义为从压力中恢复的能力。没有文献研究弹性对足部和踝关节手术后结果的影响。回顾性分析2011年9月至2020年5月进行首次MTP关节融合术的患者的患者特征和愈合状况。收集PROMIS生理功能(PF)、疼痛干扰(PI)、抑郁(D)和足功能指数(FFI)。心理弹性采用简短心理弹性量表进行测量。进行了多变量线性回归分析,考察了弹性对患者报告的影响。在术后平均3.4年,恢复力被发现独立影响患者报告的所有工具的结果,除了FFI疼痛量表。在第一项研究中,我们考察了足部和踝关节手术后弹性的影响,我们发现弹性对MTP关节融合术后的整体身体功能、残疾、疼痛和心理健康有独立的积极影响。术前恢复力评分可用于预测MTP关节融合术后的术后功能结局,并指导术后康复。这些发现有助于确定早期积极的社会心理特征在矫形足和踝关节人群中的作用。
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引用次数: 0
Traumatic Lesser Metatarsal Fractures: A Case Series and Review of the Literature 外伤性小跖骨骨折:病例系列及文献回顾
Q4 Medicine Pub Date : 2022-05-16 DOI: 10.3390/osteology2020009
C. Zale, M. Cusí, P. Ryan
Background: metatarsal fractures are a commonly encountered musculoskeletal injury. Scant literature exists to support current treatment guidelines and few studies describe the functional or occupational outcomes of patients with lesser metatarsal fractures. The purpose of this study is to describe occupational outcomes for traumatic lesser metatarsal fractures in relation to current treatment guidelines. Methods: a retrospective review of metatarsal fractures in adult military patients 18 years and older was performed. Data included: patient demographics, fracture angulation and displacement, treatment modality, associated injuries, rate of return to active duty, requirement for additional surgeries, ability to run a 2-mile physical fitness test, and presence of permanent activity limitations. Treatment guideline criteria were applied and compared with the occupational outcomes measured. Results: 38 fractures were included. The mean age was 27.2 ± 7.8 (19–48). Here, 28 fractures were initially treated non-operatively. Fractures selected for non-operative treatment had a mean displacement of 1.7 +/− 1.1 mm and a mean angulation of 3.3 +/− 3.5° at initial presentation. Fractures selected for operative treatment had a mean displacement of 4.5 +/− 2.4 mm and a mean angulation of 15.7 +/− 13.8° at initial presentation. The return to run rate was 89% in non-operatively treated patients and 50% in operatively treated patients (p = 0.02). Non-operative patients returned to running at a mean of 119 +/− 103 days and operative patients returned to running at a mean of 306 +/− 191 days (p = 0.0039). 50% of operatively treated patients and 11% of non-operatively treated patents were unable to remain in the military due to their metatarsal fractures. Conclusions: patients treated non-operatively were more likely to return to running and returned to running sooner than operatively treated patients. Current treatment guidelines could not be supported or refuted based upon the study results. The occupational and functional outcomes demonstrated in this study may assist surgeons in counseling patients on their planned treatment and anticipated recovery following a lesser metatarsal fracture.
背景:跖骨骨折是一种常见的肌肉骨骼损伤。很少有文献支持目前的治疗指南,也很少有研究描述小跖骨骨折患者的功能或职业结局。本研究的目的是描述创伤性小跖骨骨折的职业结局与当前治疗指南的关系。方法:对18岁及以上成年军人的跖骨骨折进行回顾性分析。数据包括:患者人口统计数据、骨折角度和移位、治疗方式、相关损伤、重返现役率、额外手术需求、进行2英里体能测试的能力以及是否存在永久性活动限制。应用治疗指南标准并与测量的职业结果进行比较。结果:共纳入38例骨折。平均年龄27.2±7.8(19-48)岁。在这里,28例骨折最初采用非手术治疗。选择非手术治疗的骨折在初次出现时平均移位1.7 +/ - 1.1 mm,平均成角3.3 +/ - 3.5°。选择手术治疗的骨折在初始表现时平均位移为4.5 +/ - 2.4 mm,平均角度为15.7 +/ - 13.8°。非手术治疗组的复发率为89%,手术治疗组为50% (p = 0.02)。非手术患者恢复跑步平均为119 +/ - 103天,手术患者恢复跑步平均为306 +/ - 191天(p = 0.0039)。50%的手术治疗患者和11%的非手术治疗患者由于跖骨骨折无法继续留在军队。结论:非手术治疗的患者比手术治疗的患者更有可能恢复跑步,并且恢复跑步的时间更快。目前的治疗指南不能根据研究结果来支持或反驳。本研究显示的职业和功能结果可以帮助外科医生对小跖骨骨折后患者的计划治疗和预期恢复进行咨询。
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引用次数: 1
Bilateral Achilles Tendon Rupture: A Case Report and Review of the Literature 双侧跟腱断裂1例报告及文献复习
Q4 Medicine Pub Date : 2022-04-26 DOI: 10.3390/osteology2020008
C. Cruz, J. Wake, Ryan J. Bickley, Logan Morin, Brian J Mannino, Kevin P. Krul, P. Ryan
While Achilles tendon injuries are common amongst the general population, there are very few cases in which simultaneous bilateral injuries occur. Medial malleolar fractures at the time of Achilles tendon rupture have been cited in the literature and are commonly missed. The following case outlines the presentation, treatment, and outcome of a United States Army Soldier with simultaneous bilateral Achilles tendon ruptures in addition to a unilateral right medial malleolar fracture. This patient was able to completely return to duty within 1 year after being treated with ORIF of the medial malleolus, bilateral end-to-end repair of the AT, and accelerated rehabilitation beginning at 2 weeks on the left and 6 weeks on the right.
虽然跟腱损伤在一般人群中很常见,但很少有病例同时发生双侧损伤。跟腱断裂时的内踝骨折在文献中被引用,但通常被遗漏。以下病例概述了一名美国陆军士兵同时发生双侧跟腱断裂和单侧右内侧踝骨折的表现、治疗和结果。该患者在接受内踝ORIF治疗,双侧端到端AT修复,并于左侧2周和右侧6周开始加速康复后,在1年内完全恢复工作。
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引用次数: 2
Current Perspectives on Rotator Cuff Disease 当前对肩袖疾病的看法
Q4 Medicine Pub Date : 2022-03-29 DOI: 10.3390/osteology2020007
Barbara Juliette Mera
Rotator cuff (RC) disease, defined as any pathological state of the rotator cuff, is one of the most common shoulder conditions worldwide. It accounts for 70% of shoulder pain and dysfunction in adults and is the third most prevalent musculoskeletal disorder. Currently, the main issue with rotator cuff disease is that surgery represents the most common treatment performed. However, rotator cuff surgeries have a high failure rate positively correlated with the severity of the tear, and a high re-tear rate. This review will focus on the current research perspectives of rotator cuff repairs as well as new advances in the field. Current research is shifting its focus to target the healing and tendon repair process in an aim to decrease the failure rates. The bulk of research right now is within biologic methods based on growth factors, repair scaffolds, and stem cells that promote healing. Among this, researchers are continuously trying to improve surgical techniques. The complement of both methods should pave the way for much more effective, longer-lasting rotator cuff repairs.
肩袖疾病,定义为肩袖的任何病理状态,是世界范围内最常见的肩部疾病之一。它占成人肩部疼痛和功能障碍的70%,是第三大最常见的肌肉骨骼疾病。目前,肩袖疾病的主要问题是手术是最常见的治疗方法。然而,肩袖手术失败率高,与撕裂的严重程度呈正相关,并且再撕裂率高。本文将对肩袖修复的研究现状和最新进展进行综述。目前的研究正将重点转移到肌腱的愈合和修复过程,以降低失败率。目前的大部分研究都是基于生长因子、修复支架和促进愈合的干细胞的生物方法。其中,研究人员不断尝试改进手术技术。这两种方法的互补应该为更有效、更持久的肩袖修复铺平道路。
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引用次数: 1
Evolution of Anesthetic Techniques for Shoulder Surgery: A Narrative Review 肩部手术麻醉技术的发展:述评
Q4 Medicine Pub Date : 2022-03-06 DOI: 10.3390/osteology2010006
F. Gargano, Sabrina Migliorelli, A. Strumia, M. Carassiti, F. Agrò
Shoulder surgery has radically evolved within the last 70 years, from a marginal orthopedic sub-specialty to an area of great research and advancement; consequently, anesthetic techniques have undergone important development. In fact, a wide variety of anesthetic strategies have emerged, to provide anesthesia and post-operative analgesia: general anesthesia (GA), regional anesthesia (RA), or combined GA and RA. A literature review on online databases was carried out about the different anesthetic approaches for shoulder surgery and their evolution through the years, taking in consideration papers from 1929 to 2021. A comprehensive preoperative assessment of patients undergoing shoulder surgery allows to identify and modify potential risk factors and complications of general anesthesia. Moreover, the use of ultrasound-guided regional blocks could improve the effectiveness of these techniques and bring better postoperative outcomes. Anesthetic management for shoulder surgery has progressed drastically during the last century. More studies are needed to finally standardize anesthetic techniques for specific procedure.
肩部手术在过去的70年里发生了根本性的发展,从一个边缘的骨科专科到一个伟大的研究和进步的领域;因此,麻醉技术经历了重要的发展。事实上,已经出现了各种各样的麻醉策略,以提供麻醉和术后镇痛:全身麻醉(GA),区域麻醉(RA),或全身麻醉和RA联合。对在线数据库进行了文献回顾,回顾了1929年至2021年的论文,研究了肩部手术的不同麻醉方法及其多年来的演变。对接受肩部手术的患者进行全面的术前评估可以识别和修改全身麻醉的潜在危险因素和并发症。此外,使用超声引导的区域块可以提高这些技术的有效性,带来更好的术后效果。肩部手术的麻醉管理在上个世纪取得了巨大的进步。需要更多的研究来最终规范特定手术的麻醉技术。
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引用次数: 3
Establishing a Resource to Assess Musculoskeletal Health in Older Adults in the Post-COVID-19 Era: Time to SaLSA? 建立一个评估后covid -19时代老年人肌肉骨骼健康的资源:SaLSA的时间?
Q4 Medicine Pub Date : 2022-02-28 DOI: 10.3390/osteology2010005
F. Laskou, Alexander Linfield, Pritti Aggarwal, E. Dennison, H. Patel
Sarcopenia and osteoporosis are associated with morbidity and mortality. The development and progression of these two interrelated conditions are related to genetic and lifestyle factors, including nutrition and physical activity. Restrictions placed on individuals due to the COVID-19 pandemic and infection have led to widespread lifestyle modifications, with data suggesting a negative impact on physical activity levels. There is an urgent need to understand the effect of the pandemic on musculoskeletal health in older adults, at a time when COVID-19 infection and restrictions remain a barrier to research studies. We tested the feasibility of recruiting local community-dwelling older people to establish a new cohort investigating musculoskeletal health—the Southampton Longitudinal Study of Ageing (SaLSA). We invited 1993 community-dwelling older adults registered at the Living Well GP partnership in Southampton, UK, to participate in a study. Questionnaires were completed by participants on health, lifestyle, medication use, comorbidities, physical activity, nutrition, sarcopenia, osteoporosis, and quality of life. Permission was sought for future contact. Descriptive statistics were used on the initial pilot of 175 returned questionnaire data. The median age of participants was 80.4 years in both sexes, 81.3 years (77.9–84) in females, and 81.1 years in males (77.3–83.6). The majority (N = 168/171, 98%) of participants were of white Caucasian background; 36/53 (68%) female participants and 38/119 (32%) male participants lived alone. Over 80% (295/353) consented to be contacted for future studies. Recruitment of participants from a primary care practice into a research study was feasible. The next steps are to perform detailed musculoskeletal phenotyping through physical performance measures, grip strength dynamometry, DXA scanning, high-resolution peripheral quantitative computed tomography (HRpQCT), thigh ultrasound, and muscle biopsy, in a subset of participants. Our vision for SaLSA is to build a platform for discovery science and mechanistic studies, with the goal of improving the health care of older people.
骨骼肌减少症和骨质疏松症与发病率和死亡率相关。这两种相互关联的疾病的发展和进展与遗传和生活方式因素有关,包括营养和身体活动。由于COVID-19大流行和感染对个人实施的限制导致了广泛的生活方式改变,数据显示对身体活动水平产生了负面影响。在COVID-19感染和限制仍然是研究的障碍之际,迫切需要了解大流行对老年人肌肉骨骼健康的影响。我们测试了招募当地社区居住的老年人来建立一个新的研究肌肉骨骼健康的队列的可行性——南安普敦老龄化纵向研究(SaLSA)。我们邀请了1993名在英国南安普敦健康生活GP合作组织注册的社区居住老年人参加一项研究。调查问卷由参与者完成,内容包括健康、生活方式、药物使用、合并症、身体活动、营养、肌肉减少症、骨质疏松症和生活质量。为今后的联系征求了许可。对175份返回的问卷数据进行初步试验,采用描述性统计。参与者的中位年龄为男女80.4岁,女性81.3岁(77.9-84岁),男性81.1岁(77.3-83.6岁)。大多数(N = 168/171, 98%)参与者为白种人背景;36/53(68%)的女性参与者和38/119(32%)的男性参与者独居。超过80%(295/353)的人同意为未来的研究联系。从初级保健实践中招募参与者进入研究是可行的。接下来的步骤是通过物理性能测量、握力测定仪、DXA扫描、高分辨率外围定量计算机断层扫描(HRpQCT)、大腿超声和肌肉活检对一部分参与者进行详细的肌肉骨骼表型分析。我们对SaLSA的愿景是建立一个发现科学和机制研究的平台,目标是改善老年人的医疗保健。
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引用次数: 2
What Are the Barriers to Adoption of a Lifestyle Associated with Optimal Peak Bone Mass Acquisition? A Qualitative Study of Young Adults in New Zealand 采用与最佳峰值骨量获取相关的生活方式的障碍是什么?新西兰年轻人的定性研究
Q4 Medicine Pub Date : 2022-02-08 DOI: 10.3390/osteology2010004
Sana Zafar, H. Denison, Hansa S Patel, E. Dennison
Objective: This study aimed to investigate the barriers to adopting lifestyle factors other than physical activity important for optimal peak bone mass (PBM) acquisition—namely, dietary factors, avoidance of cigarette smoking, and keeping alcohol consumption within recommended limits. Materials and Methods: University students and staff aged 18–35 years were recruited. Six semi-structured, in-depth focus group interviews were conducted with a total of 28 participants. The interviews were digitally recorded and transcribed. A thematic approach for data analysis using a constant comparative method was performed using NVivo software. Results: Three major themes emerged: socio-cultural barriers (peer pressure and cultural norms); personal barriers (time, cost, and diet preferences); and other barriers (medical illness and lack of symptoms associated with low bone mass density). Conclusions: We identified several barriers to adoption of lifestyle behaviours that might be beneficial to PBM acquisition. These data might facilitate the development of public health interventions designed to help young adults embrace osteoprotective lifestyles, and hence reduce the burden of osteoporotic fracture in later life.
目的:本研究旨在探讨除体育活动外对最佳峰值骨量(PBM)获得重要的生活方式因素,即饮食因素、避免吸烟和保持饮酒在推荐范围内的障碍。材料与方法:选取年龄在18-35岁的大学生和教职工。共进行了六次半结构化的深入焦点小组访谈,共有28名参与者。采访被数字化记录和转录。使用NVivo软件使用恒定比较法进行数据分析的主题方法。结果:出现了三个主要主题:社会文化障碍(同伴压力和文化规范);个人障碍(时间、成本和饮食偏好);以及其他障碍(医学疾病和缺乏与低骨密度相关的症状)。结论:我们确定了一些可能有利于PBM获得的生活方式行为的采用障碍。这些数据可能促进公共卫生干预措施的发展,旨在帮助年轻人采用保护骨的生活方式,从而减少晚年骨质疏松性骨折的负担。
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引用次数: 1
Outcomes of Operative Treatment of Forearm Deformity in Children with Osteogenesis Imperfecta: 18 Cases 成骨不全儿童前臂畸形手术治疗18例疗效分析
Q4 Medicine Pub Date : 2022-01-04 DOI: 10.3390/osteology2010003
Maegen Wallace, P. Esposito
Osteogenesis imperfecta (OI) often results in recurrent fractures and/or progressive bowing of the long bones, including the arms. Upper extremity deformity has been shown to negatively impact function. The objective of this retrospective case series is to assess the ability to correct deformity, improve function and evaluate the complications and revision rates in our patients with OI who have undergone forearm deformity correction. A retrospective study, approved by The University of Nebraska Medical Center Institutional Review Board, was conducted with OI patients who underwent forearm osteotomy and fixation of one or both forearm bones between December 2011 and August 2018. There were no exclusion criteria. The electronic medical records were reviewed for patient demographics, surgical details, revisions and complications. A total of 48 procedures on 27 forearms in 18 patients were performed during the study. Surgery was performed in children with forearm deformity and recurrent fractures that were interfering with function. Half of the patients had surgery on one forearm and half had surgery on both forearms. The majority of the patients have Type III OI. There were multiple complications, the most common being wire migration which required either replacement or advancement of the wire. In conclusion, forearm deformity in OI is possible, with good healing of osteotomies and fractures, although many patients may require multiple surgical interventions.
成骨不全症(OI)常导致复发性骨折和/或长骨进行性弯曲,包括手臂。上肢畸形已被证明对功能有负面影响。本回顾性病例系列的目的是评估矫治前臂畸形的能力,改善功能,评估接受前臂畸形矫治的成骨不全患者的并发症和矫治率。内布拉斯加州大学医学中心机构审查委员会批准了一项回顾性研究,该研究对2011年12月至2018年8月期间接受前臂截骨和单侧或双侧前臂骨固定的成骨不全患者进行了研究。没有排除标准。审查了电子病历的患者人口统计、手术细节、修订和并发症。在研究期间,共对18例患者的27只前臂进行了48次手术。手术是在儿童前臂畸形和复发骨折干扰功能。一半的患者在一只前臂上做了手术,一半的患者在两只前臂上做了手术。大多数患者为III型成骨不全。有多种并发症,最常见的是金属丝移位,需要更换或推进金属丝。总之,在截骨术和骨折愈合良好的情况下,成骨不全患者可能出现前臂畸形,尽管许多患者可能需要多次手术干预。
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引用次数: 1
Bone-Regulating MicroRNAs and Resistance Exercise: A Mini-Review 骨调节microrna和阻力运动:综述
Q4 Medicine Pub Date : 2022-01-03 DOI: 10.3390/osteology2010002
D. Bemben, Zhaojing Chen, S. Buchanan
MicroRNAs (miRNA) are a class of short noncoding RNA that play important roles in controlling gene expression. Many miRNAs have been identified as being important regulators of bone cell function, thus affecting the bone remodeling processes. In addition to being expressed in specific tissues and exerting intracellular effects, miRNAs can enter the blood where they can be taken up by other tissues. These circulating miRNAs (c-miRNA) also have clinical significance as biomarkers of musculoskeletal diseases as they are tissue-specific, are stable and easily detectable, and require minimally invasive procedures. This mini-review discusses miRNAs with regulatory roles in bone metabolism and c-miRNA responses to acute bouts of resistance exercise. MiRNA responses (e.g., upregulation/downregulation of expression) vary depending on the resistance exercise protocol characteristics and the age of the participants. There are gaps in the literature that need to be addressed as most of the resistance exercise studies focused on miRNAs that regulate skeletal muscle in male participants.
MicroRNAs (miRNA)是一类短链非编码RNA,在基因表达调控中起重要作用。许多mirna已被确定为骨细胞功能的重要调节因子,从而影响骨重塑过程。mirna除了在特定组织中表达并发挥细胞内作用外,还可以进入血液,被其他组织吸收。这些循环mirna (c-miRNA)作为肌肉骨骼疾病的生物标志物也具有临床意义,因为它们具有组织特异性,稳定且易于检测,并且需要微创手术。这篇综述讨论了mirna在骨代谢和c-miRNA对急性抵抗运动反应中的调节作用。MiRNA反应(如表达上调/下调)因阻力运动方案特点和参与者的年龄而异。由于大多数阻力运动研究都集中在调节男性骨骼肌的mirna上,因此需要解决文献中的空白。
{"title":"Bone-Regulating MicroRNAs and Resistance Exercise: A Mini-Review","authors":"D. Bemben, Zhaojing Chen, S. Buchanan","doi":"10.3390/osteology2010002","DOIUrl":"https://doi.org/10.3390/osteology2010002","url":null,"abstract":"MicroRNAs (miRNA) are a class of short noncoding RNA that play important roles in controlling gene expression. Many miRNAs have been identified as being important regulators of bone cell function, thus affecting the bone remodeling processes. In addition to being expressed in specific tissues and exerting intracellular effects, miRNAs can enter the blood where they can be taken up by other tissues. These circulating miRNAs (c-miRNA) also have clinical significance as biomarkers of musculoskeletal diseases as they are tissue-specific, are stable and easily detectable, and require minimally invasive procedures. This mini-review discusses miRNAs with regulatory roles in bone metabolism and c-miRNA responses to acute bouts of resistance exercise. MiRNA responses (e.g., upregulation/downregulation of expression) vary depending on the resistance exercise protocol characteristics and the age of the participants. There are gaps in the literature that need to be addressed as most of the resistance exercise studies focused on miRNAs that regulate skeletal muscle in male participants.","PeriodicalId":36674,"journal":{"name":"Clinical Osteology","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76041877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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Clinical Osteology
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