Pub Date : 2020-10-09DOI: 10.3390/osteology1010002
Henrietta O. Fasanya, D. Siemann
The upregulation of proteolytic enzymes has been demonstrated to promote primary tumor development and metastatic bone cancer. The secreted proteases increase tumor growth and angiogenesis, and potentiate neoplastic cell dissemination. This article reviews the role and mechanisms of cathepsins in normal physiology, cancer, bone remodeling, and the tumor–bone interface, with a specific focus on cathepsins B, D, H, G, L, and K. In this review, we highlight the role of cathepsins in primary bone cancer (i.e., osteosarcoma (OS)), as well as metastatic breast (BCa) and prostate (PCa) cancer. In addition, we discuss the clinical utility and therapeutic potential of cathepsin-targeted treatments in primary and secondary bone cancers.
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Pub Date : 2020-05-27DOI: 10.3390/osteology1010001
U. Longo
The fascinating field of osteology is rapidly developing [...]
骨学这个迷人的领域正在迅速发展[…]
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