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Acknowledgment to the Reviewers of Osteology in 2022 2022年骨科审稿人致谢
Q4 Medicine Pub Date : 2023-01-19 DOI: 10.3390/osteology3010003
High-quality academic publishing is built on rigorous peer review [...]
高质量的学术出版建立在严格的同行评审的基础上[…]
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引用次数: 0
Vitamin D Deficiency in Orthopedic Patients in Different Latitudes—First Study Comparing German and Greek Populations 不同纬度骨科患者的维生素D缺乏症——首次比较德国和希腊人群的研究
Q4 Medicine Pub Date : 2023-01-06 DOI: 10.3390/osteology3010002
A. Mamilos, C. Matzaroglou, G. Maier, Samer Zawy Alsofy, P. Drees, K. Kafchitsas
Vitamin D plays a pivotal role in calcium metabolism and bone mineralization. Sufficient vitamin D levels are important for the health and functionality of the musculoskeletal system. Hypovitaminosis D is a phenomenon affecting orthopedic patients worldwide. This study researched whether most orthopedic patients in two different cities of different countries had hypovitaminosis D, whether there was a correlation between sunshine hours and vitamin D serum levels, and whether hours of sunshine alone were enough to achieve vitamin D sufficiency among orthopedic patients regardless of their activities. The vitamin D serum levels of 500 orthopedic patients in Regensburg and 500 in Patras were assessed, in addition to their medical histories. The mean sunshine hours throughout the year were also calculated. Both the German and Greek groups showed hypovitaminosis D. Older patients were more affected. Although there were more hours of sunshine in Greece, Greek orthopedic patients also showed hypovitaminosis D. Hypovitaminosis D affects orthopedic patients independent of their latitude. Supplementation of vitamin D may be considered among orthopedic patients to achieve sufficient levels in serum. Sufficient vitamin D levels may be helpful for the treatment of orthopedic patients, reduce the negative effects of operations or postoperational settings.
维生素D在钙代谢和骨矿化中起着关键作用。充足的维生素D水平对肌肉骨骼系统的健康和功能很重要。维生素D缺乏症是影响全世界骨科患者的普遍现象。本研究研究了不同国家的两个不同城市的骨科患者是否大多数患有维生素D缺乏症,日照时数与血清维生素D水平是否存在相关性,以及骨科患者无论从事何种活动,仅日照时数是否足以达到维生素D充足。除了病史外,还评估了雷根斯堡500名骨科患者和帕特雷500名骨科患者的血清维生素D水平。全年的平均日照时数也被计算出来。德国和希腊的人群都表现出维生素d缺乏症,年龄较大的患者受影响更大。尽管希腊的日照时间更长,但希腊骨科患者也出现了维生素D缺乏症。维生素D缺乏症对骨科患者的影响与纬度无关。骨科患者可以考虑补充维生素D以达到足够的血清水平。充足的维生素D水平可能有助于骨科患者的治疗,减少手术或术后环境的负面影响。
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引用次数: 0
Roles of Two F-Box Proteins: FBXL14 in the Periosteum and FBXW2 at Elastic Fibers 两个F-Box蛋白:FBXL14在骨膜中的作用和FBXW2在弹性纤维中的作用
Q4 Medicine Pub Date : 2023-01-05 DOI: 10.3390/osteology3010001
M. Akiyama
I previously reported that F-box/leucine-rich repeat protein 14 (FBXL14) expressed in periosteum-derived cells, and F-box and WD-40 domain-containing protein 2 (FBXW2) in the periosteum form a fiber-like structure. Here, two culture medium conditions, that is, media with and without ascorbic acid, were compared during explant culture. In the absence of ascorbic acid, the expression patterns of osteocalcin, FBXW2, and elastin were compared using fluorescent immunostaining during weeks 3–5. By observing the periosteum, cambium layer and bone, I demonstrated FBXL14 expression in micro-vessels and bone lacuna. Fluorescent immunostaining revealed that, without ascorbic acid, the FBXL14 layer was thin. Conversely, in the presence of ascorbic acid, FBXL14 formed a thick membrane-like structure inside the periosteum, and the multilayer of periosteum-derived cells (PDCs) was strong. The expression patterns of osteocalcin and FBXW2 were similar. Elastin retained its fiber structure for up to five weeks. Although osteocalcin and FBXW2 were expressed in regions similar to elastin, they could not retain their fiber structures. In conclusion, FBXL14 appears to play a role in preparing a native scaffold for forming a multilayered sheet of PDCs inside the periosteum. FBXW2 and osteocalcin appear to separate from elastic fibers during calcification.
我之前报道过F-box/leucine-rich repeat protein 14 (FBXL14)在骨膜源性细胞中表达,骨膜中的F-box和WD-40结构域蛋白2 (FBXW2)形成纤维样结构。在外植体培养过程中,比较了两种培养基条件,即含抗坏血酸培养基和不含抗坏血酸培养基。在缺乏抗坏血酸的情况下,采用荧光免疫染色法比较3-5周骨钙素、FBXW2和弹性蛋白的表达模式。通过观察骨膜、形成层和骨,我发现FBXL14在微血管和骨陷窝中表达。免疫荧光染色显示,未加抗坏血酸后,FBXL14层变薄。相反,当抗坏血酸存在时,FBXL14在骨膜内形成较厚的膜样结构,骨膜衍生细胞(PDCs)的多层性较强。骨钙素和FBXW2的表达模式相似。弹性蛋白保持其纤维结构长达五周。尽管骨钙素和FBXW2在与弹性蛋白相似的区域表达,但它们不能保留其纤维结构。综上所述,FBXL14似乎在制备天然支架以在骨膜内形成多层pdc片方面发挥作用。在钙化过程中,FBXW2和骨钙素与弹性纤维分离。
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引用次数: 0
Depressive Symptoms as Potential Mediator between Physical Activity and Bone Health—A Scoping Review 抑郁症状作为体力活动和骨骼健康之间的潜在中介——范围综述
Q4 Medicine Pub Date : 2022-12-14 DOI: 10.3390/osteology2040020
S. Houtenbos, L. Kuehl, K. Wuertz-Kozak, P. Wippert
Depression constitutes a risk factor for osteoporosis (OP). Increasing physical activity might mitigate this risk, although intensive exercising may lead to opposing effects in depressed patients. The purpose of this scoping review was to summarize the evidence regarding the influence of exercise on bone health in depressed patients, divided into two sections: (1) Which bone markers are affected by depression? (2) How does exercise affect bone health in patients with depressive symptoms? A search of the literature was conducted in PubMed and Web of Science between August 2020–2022. Studies were included based on predetermined criteria for each sub-question. Regarding sub-question 1, eight studies revealed the following bone markers to be influenced by depression: P1NP, BAP, CTX, OC, RANKL, OPG, DPD, and PYD. Regarding sub-question 2, one study found a correlation between depression and bone health in an exercising population, and other studies detected improvements in bone health (n = 4) and depressive symptoms (n = 4) after exercise interventions. The current review shows the potential of exercise as a treatment form to improve bone health in depressed patients. Future trials are needed to assess the influence of exercise intervention on bone health in depressed patients.
抑郁症是骨质疏松症(OP)的危险因素。增加体力活动可能会减轻这种风险,尽管高强度运动可能会对抑郁症患者产生相反的效果。本综述的目的是总结有关运动对抑郁症患者骨骼健康影响的证据,分为两个部分:(1)哪些骨骼标志物受到抑郁症的影响?(2)运动如何影响抑郁症状患者的骨骼健康?在2020年8月至2022年8月期间,在PubMed和Web of Science上进行了文献检索。根据每个子问题的预定标准纳入研究。关于子问题1,8项研究揭示了以下骨标志物受抑郁影响:P1NP、BAP、CTX、OC、RANKL、OPG、DPD和PYD。关于子问题2,一项研究发现运动人群的抑郁与骨骼健康之间存在相关性,其他研究发现运动干预后骨骼健康(n = 4)和抑郁症状(n = 4)有所改善。目前的综述表明,运动作为一种治疗形式,有可能改善抑郁症患者的骨骼健康。未来的试验需要评估运动干预对抑郁症患者骨骼健康的影响。
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引用次数: 0
Severe Quadriceps Heterotopic Ossification after Knee Revision Arthroplasty in a 42-Year-Old Suffering from Rheumatoid Arthritis: A Case Report 42岁类风湿关节炎患者膝关节置换术后严重股四头肌异位骨化1例
Q4 Medicine Pub Date : 2022-12-07 DOI: 10.3390/osteology2040019
M. Massaro, F. Mela, R. Espósito, Emanuele Maiorano, Guy Laskow
Background: Heterotopic Ossification (HO) of the knee is most commonly formed anteriorly to the distal femoral shaft in the quadriceps expansion. Although the incidence of severe HO with large dimensions affecting the knee and resulting in severe consequences is extremely rare, these cases are extremely difficult to prevent and have severe clinical limitations for the patient. Aim: The purpose of this study was to present and explore HO formation after Total Knee Arthroplasty (TKA). Conclusions: It is crucial to perform a stratification of patients for the risk of HO formation after TKA and to gain a better understanding of the fundamental role of post-operative treatments. In severe HO, surgery should be considered following appropriate investigations and should only be considered when the HO has fully matured. In comparison to Total Hip Arthroplasty (THA), HO formation after TKA is less frequent and underexplored. Therefore, further studies are required. This case report can represent a protocol for the treatment of clinically relevant HO in the knee after TKA.
背景:膝关节异位骨化(HO)最常见于股四头肌扩张时股骨远端前部。虽然大尺寸严重HO影响膝关节并导致严重后果的发生率极低,但这些病例极难预防,对患者具有严重的临床局限性。目的:本研究的目的是探讨全膝关节置换术(TKA)后HO的形成。结论:对TKA后HO形成风险的患者进行分层和更好地了解术后治疗的基本作用是至关重要的。对于严重的HO,应在适当的调查后考虑手术,并且只有在HO完全成熟时才应考虑手术。与全髋关节置换术(THA)相比,全髋关节置换术后HO形成的频率较低且未被充分研究。因此,需要进一步的研究。本病例报告可以代表TKA后临床相关的膝关节HO的治疗方案。
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引用次数: 0
The Remplissage Technique for Hill–Sachs Lesions in Competitive Athletes: A Narrative Review 竞技运动员Hill-Sachs病变的复诊技术:述评
Q4 Medicine Pub Date : 2022-11-17 DOI: 10.3390/osteology2040018
M. Novi, S. Nicoletti
Anterior shoulder instability with Bankart lesion and associated posterior humeral head injury (Hill–Sachs) is common in athletes. Several treatments have been proposed for the management of the Hill–Sachs lesion, from bone grafts or rotation osteotomies to capsulotendinous interposition, such as remplissage. This procedure has been shown to be safe and effective in increasing glenohumeral stability. However, the correct indication concerning the bone defect and its effects in terms of range of motion and function, especially in highly demanding patients, is still debated. This narrative review aims to present the current state-of-the-art of the posterior capsulotenodesis in association with Bankart repair, for treating anterior shoulder instability in competitive athletes.
前肩不稳伴Bankart病变及相关的肱骨后头损伤(Hill-Sachs)在运动员中很常见。已经提出了几种治疗Hill-Sachs病变的方法,从骨移植或旋转截骨到肌腱包膜介入,如穿刺。该手术已被证明在提高肩关节稳定性方面是安全有效的。然而,关于骨缺损的正确适应症及其在活动范围和功能方面的影响,特别是在高要求的患者中,仍然存在争议。这篇叙述性综述的目的是介绍与Bankart修复术相关的后囊膜固定术治疗竞技运动员前肩不稳的最新进展。
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引用次数: 0
Percutaneous Vertebroplasty: A Minimally Invasive Procedure for the Management of Vertebral Compression Fractures 经皮椎体成形术:一种治疗椎体压缩性骨折的微创手术
Q4 Medicine Pub Date : 2022-10-10 DOI: 10.3390/osteology2040017
E. Faiella, G. Pacella, C. Altomare, C. Bernetti, M. Sarli, Laura Cea, F. Russo, G. Vadalà, B. Beomonte Zobel, R. Grasso
A vertebral compression fracture (VCF) is a pathological condition, which can be caused by osteoporotic degeneration or metastatic disease. It represents a socioeconomic burden on healthcare systems, due to increased pain, long-term morbidity, and disability. Vertebroplasty (VP) is an image-guided, minimally invasive, interventional procedure, in which bone cement is injected via a percutaneous approach into the vertebral soma, to provide structural support and to stabilize the weakened structure. The aim of this narrative review is to describe vertebral column biomechanics, as well as indications, contraindications, and techniques to successfully perform VP for the treatment of VCFs. Methods: We performed a narrative literature review on the main online databases regarding VP, and mainly focused on patient selection, preoperative imaging, procedural steps, complications, and outcomes. Results: The most recent evidence in the literature has shown that VP provides significant and sustained clinical benefits for patients with a VCF, and it is indicated in patients with comorbidities that make prolonged bed rest dangerous, patients with fractures that fail to heal, and as palliation in patients with a painful VCF due to metastatic disease. Conclusions: VP is considered to be a safe and effective treatment option for the treatment of osteoporotic and malignant VCFs that are resistant to adequate medical therapy. Patient selection, preprocedural evaluation, and proper technique execution are the key points to obtain the best outcomes and to minimize complications.
椎体压缩性骨折(VCF)是一种病理状态,可由骨质疏松变性或转移性疾病引起。由于疼痛增加、长期发病和残疾,它给医疗保健系统带来了社会经济负担。椎体成形术(VP)是一种图像引导的微创介入性手术,通过经皮入路将骨水泥注入椎体,以提供结构支持并稳定脆弱的结构。这篇叙述性综述的目的是描述脊柱生物力学,以及适应症、禁忌症和成功实施VP治疗vcf的技术。方法:我们对关于VP的主要在线数据库进行了叙述性文献回顾,主要集中在患者选择,术前影像学,手术步骤,并发症和结局。结果:文献中最新的证据表明,VP为VCF患者提供了显著且持续的临床益处,适用于有合并症导致长时间卧床休息危险的患者,骨折无法愈合的患者,以及因转移性疾病引起的疼痛性VCF患者。结论:VP被认为是治疗耐药的骨质疏松性和恶性vcf的一种安全有效的治疗选择。患者选择、术前评估和正确的技术执行是获得最佳结果和减少并发症的关键。
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引用次数: 0
Osteology as a Forum for Research on the ‘Living Mineral’: Bone 作为“活矿物”研究论坛的骨学:骨
Q4 Medicine Pub Date : 2022-08-30 DOI: 10.3390/osteology2030016
S. Braga
About 400 million years ago, the first bone-like material, aspidin, was developed for external protection for the body of invertebrate marine creatures; this mineral shell is now believed to function as a reservoir for phosphorous and calcium [...]
大约4亿年前,人类发明了第一种类似骨头的物质——蜘蛛素,用来保护无脊椎海洋生物的身体;这种矿物外壳现在被认为是磷和钙的储存库[…]
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引用次数: 0
The Glenoid Track Concept: On-Track and Off-Track—A Narrative Review 格伦oid轨道概念:轨道上和偏离轨道-叙述回顾
Q4 Medicine Pub Date : 2022-07-19 DOI: 10.3390/osteology2030015
Antonio Ventura, Claudia Smiraglio, A. Viscomi, S. De Salvatore, B. Bertucci
Shoulder instability is described as a functional deficiency caused by excessive mobility of the humeral head over the glenoid. Various Glenohumeral Instability (GI) types have been described, but the traumatic anteroinferior form is the most frequent. The differences between engaging and non-engaging Hill–Sachs lesions (HSLs) are linked to bone loss assessment. On the contrary, the novel difference between “on-track” and “off-track” lesions is strictly related to surgical techniques. The specific involvement of glenoid and humerus bone defects in recurrent GI was poorly assessed in the literature before the glenoid-track concept (GT). Magnetic Resonance Imaging (MRI) and Arthro-MRI have been widely used to identify and characterize lesions to the ligamentous structures. However, only new technologies (3 Tesla MRI) accurately detect HSLs. On the contrary, Computed Tomography (CT) has been adopted to quantify glenoid bone deficit. The GT concept is a valuable tool for evaluating anterior shoulder instability in patients. Shoulders out of alignment may require more than just an arthroscopic Bankart, and a remplissage or bone transfer may be necessary. Specifically, isolated Bankart repair should be considered in patients with recurrent instability and an on-track lesion with less than 25% glenoid bone loss. In off-track lesions and less than 25% glenoid bone loss, remplissage should be used. Bone transplant surgery is required for patients with a glenoid bone defect of more than 25%. This narrative review aims to report the most updated findings on “on-track” and “off-track” lesions in GI.
肩部不稳定被描述为肩关节上方肱骨头过度活动引起的功能缺陷。各种类型的盂肱部不稳(GI)已被描述,但外伤性前下型是最常见的。累及性和非累及性Hill-Sachs病变(hsl)的差异与骨质流失评估有关。相反,“轨迹内”和“轨迹外”病变之间的新差异与手术技术密切相关。在盂-径概念(GT)出现之前,文献对复发性胃肠道中盂和肱骨骨缺损的具体受累情况评估甚少。磁共振成像(MRI)和关节磁共振成像已被广泛用于识别和表征韧带结构的病变。然而,只有新技术(3特斯拉MRI)才能准确检测高hsl。相反,计算机断层扫描(CT)已被用于量化关节盂骨缺损。GT概念是评估患者前肩不稳的一个有价值的工具。肩部错位可能需要的不仅仅是关节镜下的Bankart,还可能需要复模或骨转移。具体来说,对于复发性不稳定和关节轨迹病变且关节盂骨丢失小于25%的患者,应考虑孤立Bankart修复。对于偏离轨道的病变和小于25%的关节盂骨丢失,应使用复位。关节盂骨缺损超过25%的患者需要进行骨移植手术。这篇叙述性综述的目的是报道胃肠道“顺行”和“偏离”病变的最新发现。
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引用次数: 0
Calcific Shoulder Tendinopathy (CT): Influence of the Biochemical Process of Hydrolysis of HA (Hydroxyapatite) on the Choice of Ultrasound-Guided Percutaneous Treatment (with the Three-Needle Technique) 钙化性肩腱病(CT):羟基磷灰石水解生化过程对超声引导下经皮治疗(三针技术)选择的影响
Q4 Medicine Pub Date : 2022-06-27 DOI: 10.3390/osteology2030013
S. Galletti, M. Miceli, S. M. Stella, F. Vita, D. Bigliardi, Danilo Donati, D. Creta, A. Frizziero
Calcific shoulder tendinopathy (CT) is a common condition involving the central part or insertion of the rotator cuff tendons (RC) or the subacromial-subdeltoid bursa (SASD). The calcific deposits consist of poorly crystallized calcium hydroxyapatite but the mechanism of their formation still remains unclear. CT can be divided into three distinct stages, as reported by Uthhoff et al. Clinically, this condition varies with the extent of the calcification and the phase of the condition. In particular, the disorder is asymptomatic or may cause mild discomfort during the deposition of calcium, while it becomes acutely painful during the resorptive phase. US-PICT (ultrasound-guided percutaneous irrigation of calcific tendinopathy) is indicated in the acute phase (resorptive phase) of CT with significant pain relief and a very low rate of minor complications. The aim of this manuscript is to define the rationale of the ultrasound-guided percutaneous irrigation of calcific tendinopathy, correlating it with the sequence of biochemical processes that lead to the hydrolysis of hydroxyapatite. Furthermore, we will explain the reasons why we prefer using the three-needle technique for the dissolution of calcifications.
钙化性肩腱病(CT)是一种累及肩袖肌腱(RC)或肩峰下-三角下滑囊(ssd)的常见疾病。钙化沉积物由钙羟基磷灰石结晶不良组成,但其形成机制尚不清楚。根据Uthhoff等人的报道,CT可以分为三个不同的阶段。临床上,这种情况随钙化程度和病情的分期而变化。特别是,这种疾病在钙沉积期间无症状或可能引起轻度不适,而在钙吸收期则会出现剧烈疼痛。超声引导下经皮钙化肌腱病变冲洗术US-PICT(超声引导下经皮钙化肌腱病变冲洗术)适用于CT急性期(吸收期),疼痛明显缓解,轻微并发症发生率极低。本文的目的是定义超声引导下经皮冲洗钙化肌腱病的基本原理,并将其与导致羟基磷灰石水解的生化过程序列联系起来。此外,我们将解释为什么我们更喜欢使用三针技术来溶解钙化。
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引用次数: 0
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Clinical Osteology
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