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EGEA Collection: A Biobank Devoted to Asthma and Asthma-related Phenotypes EGEA集合:一个致力于哮喘和哮喘相关表型的生物库
Q2 Medicine Pub Date : 2017-04-04 DOI: 10.5334/OJB.24
R. Nadif, E. Bouzigon, N. Moual, V. Siroux
The Epidemiological study on the Genetics and Environment of Asthma (EGEA) is a 20-year cohort including cases with asthma (n = 388), their first degree relatives (n = 1244) and population-based controls (n = 415) recruited in the early 90’s from five French cities. Participants were extensively characterized regarding environment and respiratory health, and a specific effort was made to trace and bank biological samples (ISO 9001 certification since 2006). Access to data and samples is opened to researchers wishing to develop new scientific collaborative programs. The survey has already led to more than a hundred papers with almost one third in collaboration with national and international teams.
哮喘遗传与环境流行病学研究(EGEA)是一项20年的队列研究,包括90年代初从法国五个城市招募的哮喘病例(n=388)、其一级亲属(n=1244)和基于人群的对照组(n=415)。参与者被广泛介绍了环境和呼吸系统健康方面的情况,并特别努力追踪和储存生物样本(自2006年以来通过了ISO9001认证)。希望开发新的科学合作项目的研究人员可以获得数据和样本。这项调查已经产生了100多篇论文,其中近三分之一是与国家和国际团队合作撰写的。
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引用次数: 8
The Parelsnoer Institute: A National Network of Standardized Clinical Biobanks in the Netherlands parrelsnoer研究所:荷兰标准化临床生物银行的国家网络
Q2 Medicine Pub Date : 2017-02-17 DOI: 10.5334/OJB.23
J. Manniën, T. Ledderhof, H. Verspaget, R. Snijder, E. Flikkenschild, Nicole P. C. van Scherrenburg, R. Stolk, G. Zielhuis
The Parelsnoer Institute (PSI) is a collaborative biobanking project of all eight University Medical Centers in the Netherlands which was launched in 2007. Basically, PSI consists of three dimensions: participating institutions, disease entities and a central organization. An executive board for operational management instigates collective strategic and tactic policies and a central team of PSI experts and advisors supports the researchers and the board in establishing and implementing standards and procedures. PSI offers researchers an infrastructure and standard procedures for the establishment, expansion and optimisation of clinical biobanks for scientific research. To ensure patient privacy clinical data is pseudomized and carefully stored in a central database. Human biomaterials are collected according to nationally agreed standards. Currently PSI covers fifteen large disease specific cohorts (the so-called ‘Parels’ or ‘Pearls’) and new ‘Pearls’ are being developed. The Parelsnoer Institute currently (December 2016) has stored more than 538,000 biospecimens with annotated clinical data of more than 30,000 patients. All these materials and data are available for anyone with a bona fide research proposal.
Parelsnoer研究所(PSI)是荷兰所有八个大学医学中心的合作生物库项目,于2007年启动。基本上,PSI由三个方面组成:参与机构、疾病实体和一个中央组织。运营管理执行委员会制定集体战略和战术政策,PSI专家和顾问的中央团队支持研究人员和委员会制定和实施标准和程序。PSI为研究人员提供了建立、扩展和优化科学研究临床生物库的基础设施和标准程序。为了确保患者隐私,临床数据被伪造并小心地存储在中央数据库中。人类生物材料是根据国家认可的标准收集的。目前,PSI涵盖了15个大型疾病特异性队列(所谓的“Parels”或“Pearls”),新的“Pearl斯”正在开发中。Parelsnoer研究所目前(2016年12月)已经存储了538000多个生物样本,其中包含30000多名患者的注释临床数据。所有这些材料和数据都可供任何有真正研究建议的人使用。
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引用次数: 24
Biobank of Cells, Tissues and DNA from Patients with Neuromuscular Diseases: An Indispensable link between Clinical Centers and the Scientific Community 神经肌肉疾病患者的细胞、组织和DNA生物库:临床中心和科学界之间不可或缺的联系
Q2 Medicine Pub Date : 2017-02-13 DOI: 10.5334/OJB.29
M. Mora, C. Bragato, S. Gibertini, S. Zanotti, M. Curcio, E. Canioni, F. Salerno, F. Blàsevich, S. Saredi, A. Ruggieri, M. Pasanisi, P. Bernasconi, L. Maggi, R. Mantegazza, F. Andreetta
The Biobank was established in 1986 as part of the routine diagnostic activity of the Division of Neuromuscular Diseases and Neuroimmunology, of the Carlo Besta Neurological Institute. It stores muscle tissue, cells and DNA from patients with neuromuscular diseases. The biobank provides samples as a service to the scientific community conducting research on neuromuscular disorders. Samples are from patients affected by different forms of muscular dystrophy, including the severe congenital and Duchenne muscular dystrophies, as well as limb girdle muscular dystrophies, congenital myopathies, distal and myofibrillar myopathies, inflammatory myopathies, and metabolic myopathies. Different types of biomaterials are frequently available from a single patient. The Biobank is founding partner of the EuroBioBank network, the first operating network of biobanks for rare diseases in Europe, and of the Italian Telethon Network of Genetic Biobanks. The involvement of the biobank into both networks has been instrumental for standardization of procedures and activities, implementation of sample access policies, and compliance with ELSI requirements. The biobank, with about 13000 biospecimens stored in total at the time of writing, constitutes a key source of biological samples for researchers worldwide.
生物库成立于1986年,是卡洛·贝斯塔神经研究所神经肌肉疾病和神经免疫学部门常规诊断活动的一部分。它储存神经肌肉疾病患者的肌肉组织、细胞和DNA。生物库为从事神经肌肉疾病研究的科学界提供样本服务。样本来自受不同形式肌营养不良影响的患者,包括严重的先天性和杜兴肌营养不良,以及肢带肌营养不良、先天性肌病、远端和肌原纤维肌病、炎症性肌病和代谢性肌病。不同类型的生物材料通常可从单个患者获得。生物库是欧洲生物库网络(欧洲第一个罕见病生物库运营网络)和意大利Telethon基因生物库网络的创始合作伙伴。生物库参与这两个网络有助于程序和活动的标准化、样本访问政策的实施以及ELSI要求的遵守。在撰写本文时,该生物库共存储了约13000个生物样本,是全球研究人员生物样本的关键来源。
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引用次数: 3
SDN Biobank: Bioresource of Human Samples Associated with Functional and/or Morphological Bioimaging Results for the Study of Oncological, Cardiological, Neurological, and Metabolic Diseases SDN生物库:与肿瘤、心脏病、神经和代谢疾病研究的功能和/或形态生物成像结果相关的人类样本的生物资源
Q2 Medicine Pub Date : 2017-02-13 DOI: 10.5334/OJB.26
P. Mirabelli, M. Incoronato, L. Coppola, T. Infante, C. Parente, E. Nicolai, A. Soricelli, M. Salvatore
SDN Biobank is a not-for-profit service unit. Initially, it was established by the IRCCS SDN in 2012 as a collection of serum and plasma samples from patients who underwent advanced bioimaging exams, such as those performed with Positron Emission Tomography with integrated Magnetic Resonance Imaging (PET/MRI). In July 2015, SDN Biobank was approved by the local ethics committee to collect human samples from patients affected by oncological, cardiological, neurological, and metabolic diseases when performing diagnostic exams at the IRCCS SDN. All samples are coded and associated with clinical and iconographic documentation related to the performed functional or morphological bioimaging exams. SDN Biobank procedures are carried out according to the ISO 9001 Quality Management System with internal and external audits.
SDN生物银行是一家非营利服务机构。最初,它是由IRCCS SDN于2012年建立的,收集了接受高级生物成像检查的患者的血清和血浆样本,例如使用正电子发射断层扫描和集成磁共振成像(PET/MRI)进行的检查。2015年7月,SDN生物库获得了当地伦理委员会的批准,可以在IRCCS SDN进行诊断检查时,从受肿瘤学、心脏病学、神经和代谢疾病影响的患者身上采集人体样本。所有样本都经过编码,并与所进行的功能或形态生物成像检查相关的临床和影像学文件相关联。SDN生物库程序根据ISO 9001质量管理体系进行内部和外部审计。
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引用次数: 18
The UK ME/CFS Biobank for biomedical research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Multiple Sclerosis. 英国肌痛性脑脊髓炎/慢性疲劳综合症(ME/CFS)和多发性硬化症生物医学研究数据库。
Q2 Medicine Pub Date : 2017-01-01 Epub Date: 2017-02-20 DOI: 10.5334/ojb.28
Eliana M Lacerda, Erinna W Bowman, Jacqueline M Cliff, Caroline C Kingdon, Elizabeth C King, Ji-Sook Lee, Taane G Clark, Hazel M Dockrell, Eleanor M Riley, Hayley Curran, Luis Nacul

The UK ME/CFS Biobank was launched in August 2011 following extensive consultation with professionals and patient representatives. The bioresource aims to enhance research on myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), related to pathophysiology, biomarkers and therapeutic approaches. The cohort includes 18-60 year olds, encompassing 284 clinically-confirmed ME/CFS cases, 60 neurologist-diagnosed multiple sclerosis (MS) cases, and 135 healthy individuals. The Biobank contains blood samples, aliquoted into serum, plasma, peripheral blood mononuclear cells (PBMC), red blood cells/granulocyte pellet, whole blood, and RNA (totalling 29,863 aliquots). Extensive dataset (700 clinical and socio-demographic variables/participant) enables comprehensive phenotyping. Potential reuse is conditional to ethical approval.

英国 ME/CFS 生物库于 2011 年 8 月启动,此前曾广泛征求专业人士和患者代表的意见。该生物库旨在加强对肌痛性脑脊髓炎/慢性疲劳综合征(ME/CFS)的病理生理学、生物标志物和治疗方法的研究。该群组包括 18-60 岁的人群,其中有 284 个经临床确诊的 ME/CFS 病例、60 个经神经科医生确诊的多发性硬化症(MS)病例和 135 个健康人。生物库中的血液样本包括血清、血浆、外周血单核细胞(PBMC)、红细胞/粒细胞颗粒、全血和 RNA(共计 29,863 份等分样本)。广泛的数据集(700 个临床和社会人口变量/参与者)可进行全面的表型分析。再利用的可能性取决于伦理审批。
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引用次数: 0
Biobank Lodz – DNA Based Biobank at the University of Lodz, Poland 罗兹生物库-波兰罗兹大学的DNA生物库
Q2 Medicine Pub Date : 2016-11-30 DOI: 10.5334/OJB.22
D. Strapagiel, M. Sobalska-Kwapis, M. Słomka, B. Marciniak
The Biorepository in Department of Molecular Biophysics of the University of Lodz was established in 2010 as an internal bioresource to collect and store Polish population-based biospecimens. In 2014 biorepository started to act as Biobank Lab of University of Lodz (BLUL/Biobank Lodz). The Biobank Lodz joined the BBMRI_PL (consortium of Polish biobanks) in 2014 and in 2016 BLUL became a member of the BCNet (Biobank and Cohort Building Network) and ESBB (European and Middle Eastern Society for Biopreservation and Biobanking). The BLUL stores over 12.200 samples and their data, including section of formalin fixed paraffin embedded (FFPE) and fluid samples (serum, full blood, saliva). Biobank Lodz is expanding the collections to include some important human diseases as well and is open for the international scientific community for the purpose research projects.
罗兹大学分子生物物理系生物库成立于2010年,作为内部生物资源收集和储存波兰人口生物标本。2014年biorepository开始作为Lodz大学生物库实验室(BLUL/Biobank Lodz)。生物银行Lodz于2014年加入BBMRI_PL(波兰生物银行联盟),并于2016年成为BCNet(生物银行和队列建设网络)和ESBB(欧洲和中东生物保存和生物银行协会)的成员。bll存储了超过12200个样本及其数据,包括福尔马林固定石蜡包埋(FFPE)切片和液体样本(血清、全血、唾液)。罗兹生物库正在扩大其收藏范围,以包括一些重要的人类疾病,并向国际科学界开放,用于研究项目。
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引用次数: 16
The Prostate Cancer Research Consortium Bioresource (Ireland) 前列腺癌研究联盟生物资源(爱尔兰)
Q2 Medicine Pub Date : 2016-11-15 DOI: 10.5334/OJB.12
A. Wekesa, W. Watson
The Prostate Cancer Research Consortium (PCRC) is a co-ordinated group of researchers and clinicians from universities and hospitals in Ireland whose aim is to improve the diagnosis and treatment of prostate cancer by engaging in biomarker discovery and validation research. The PCRC has established a prostate cancer bioresource that collects biological samples and comprehensive clinical information collected at time of recruitment and subsequent follow from prostate cancer patients undergoing Transurethral resection of the prostate (benign disease) or radical prostatectomy (indolent, significant and aggressive, Gleason Score 4–10). This disease based bioresource with potential for reuse has recruited ~900 patients and collected >10000 tissue, serum, plasma, urine, DNA and RNA samples.
前列腺癌研究联盟(PCRC)是一个由来自爱尔兰大学和医院的研究人员和临床医生组成的协调小组,其目的是通过参与生物标志物的发现和验证研究来改善前列腺癌的诊断和治疗。PCRC建立了一个前列腺癌生物资源,收集经尿道前列腺切除术(良性疾病)或根治性前列腺切除术(无痛、显著和侵袭性,Gleason评分4-10)的前列腺癌患者在招募和随访时收集的生物样本和全面的临床信息。这种基于疾病的生物资源具有再利用的潜力,已招募了900名患者,收集了100万份组织、血清、血浆、尿液、DNA和RNA样本。
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引用次数: 0
Biobank Graz: The Hub for Innovative Biomedical Research 格拉茨生物银行:创新生物医学研究中心
Q2 Medicine Pub Date : 2016-07-22 DOI: 10.5334/OJB.20
B. Huppertz, Michaela Bayer, T. Macheiner, K. Sargsyan
Biobank Graz was established in 2007 as publicly funded, non-profit central research facility of Medical University of Graz, Austria. Biobank Graz is ISO 9001:2008 certified and stores about 7.5 million samples and their associated data, including formalin fixed paraffin embedded (FFPE) and fresh frozen tissues plus fluid samples (serum, plasma, full blood, urine and cerebrospinal, follicular and seminal fluids, etc.) covering 30 years of collection. Samples are handled and stored in semi or fully automated systems to optimally maintain sample quality and retrieval rates. With its broad informed consent, Biobank Graz distributes samples worldwide to ethically and scientifically approved research projects from academia, industry, and cooperative studies in biomedical sciences. This is why Biobank Graz can be viewed as a central hub for biomedical research.
格拉茨生物银行成立于2007年,是奥地利格拉茨医科大学公共资助的非营利性中央研究机构。格拉茨生物库通过了ISO 9001:2008认证,存储了约750万份样本及其相关数据,包括福尔马林固定石蜡包埋(FFPE)和新鲜冷冻组织以及液体样本(血清、血浆、全血、尿液和脑脊液、卵泡和精液等),收集时间长达30年。样品处理和存储在半自动或全自动系统,以最佳地保持样品质量和检索率。凭借广泛的知情同意,格拉茨生物银行在全球范围内向学术界、工业界和生物医学科学合作研究的伦理和科学批准的研究项目分发样本。这就是为什么格拉茨生物银行可以被视为生物医学研究的中心枢纽。
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引用次数: 15
The SEARCHBreast portal: a virtual bioresource to facilitate the sharing of surplus animal materials derived from breast cancer studies SEARCHBreast门户网站:一个虚拟生物资源,以促进分享来自乳腺癌研究的剩余动物材料
Q2 Medicine Pub Date : 2016-07-22 DOI: 10.5334/OJB.21
Phil Carter, K. Blyth, I. Holen, L. Jones, Bethny Morrissey, V. Speirs, C. Chelala
The SEARCHBreast portal (https://searchbreast.org/) provides access to a virtual bioresource enabling researchers to access and share material derived from breast cancer related animal studies on a collaborative basis. By registering as members of SEARCHBreast, researchers can browse the SEARCHBreast platform for relevant tissue and models, and request access to these to help answer their specific biological question(s). SEARCHBreast mediates the collaborations formed from requests for these materials. As of July 2016, the virtual bioresource has received 8 requests for tissue and has sent hundreds of tissue samples saving approximately 400 animals. SEARCHBreast is currently developing a bioinformatics pipeline, enabling users to access and mine published data on animal models of breast cancer, potentially helping to reduce experimental redundancy further, prioritising new relevant research.
SEARCHBreast门户网站(https://searchbreast.org/)提供对虚拟生物资源的访问,使研究人员能够在协作的基础上访问和共享来自乳腺癌相关动物研究的材料。通过注册成为SEARCHBreast的会员,研究人员可以浏览SEARCHBreast平台查找相关组织和模型,并请求访问这些组织和模型以帮助回答他们特定的生物学问题。“搜索乳房”协调了对这些材料的请求所形成的合作。截至2016年7月,虚拟生物资源已收到8份组织请求,并发送了数百份组织样本,拯救了大约400只动物。SEARCHBreast目前正在开发一个生物信息学管道,使用户能够访问和挖掘关于乳腺癌动物模型的已发表数据,这可能有助于进一步减少实验冗余,优先考虑新的相关研究。
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引用次数: 0
Biobank of Psychiatric Diseases Mannheim – BioPsy 曼海姆精神疾病生物库-活检
Q2 Medicine Pub Date : 2016-07-08 DOI: 10.5334/OJB.18
S. Witt, H. Dukal, C. Hohmeyer, Slavica Radosavljevic-Bjelic, D. Schendel, J. Frank, M. Lang, F. Streit, J. Strohmaier, J. Treutlein, M. Rietschel
High quality biomaterial from patients and controls is a core prerequisite for research into the biological causes of mental disorder. BioPsy is the biobank of the Department of Genetic Epidemiology in Psychiatry at the Central Institute of Mental Health in Mannheim, Germany, and one of the largest psychiatric disorder biobanks worldwide. Here, ongoing collection is in progress for blood, DNA, mRNA, plasma, serum, saliva, urine, hair, and other biomaterials. Reuse of samples is permitted in a collaboration-based context. BioPsy operates according to German and European quality and data privacy standards.
来自患者和对照组的高质量生物材料是研究精神障碍生物学原因的核心先决条件。活检是德国曼海姆中央精神卫生研究所精神病学遗传流行病学部门的生物库,也是世界上最大的精神疾病生物库之一。在这里,正在收集血液、DNA、mRNA、血浆、血清、唾液、尿液、毛发和其他生物材料。在基于协作的上下文中允许重用样本。活组织检查按照德国和欧洲的质量和数据隐私标准操作。
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引用次数: 10
期刊
Open Journal of Bioresources
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