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Pediatric Robot-Assisted Laparoscopic and Ureteroscopic Ureterolithotomy and Ureteroplasty. 儿童机器人辅助腹腔镜和输尿管镜输尿管取石术和输尿管成形术。
Q4 Medicine Pub Date : 2020-12-29 eCollection Date: 2020-01-01 DOI: 10.1089/cren.2020.0043
Rachel A Locke, Elizabeth P Kwenda, Jeremy Archer, Jeremy Bergamo, Maria Paula Domino, Romano T DeMarco, Christopher E Bayne

Background: Pediatric urolithiasis may coexist with congenital urinary tract abnormalities, complicating conventional methods of stone treatment. Here, we present an effective case of robot-assisted laparoscopy and simultaneous ureteropyeloscopy for the definitive management of pediatric urolithiasis complicated by a congenital ureteral stricture. Case Presentation: A 3-year-old girl presented to clinic with an outside noncontrast CT scan showing two 6-7 mm nonobstructing calculi in a mildly distended upper pole moiety of a duplex left kidney. Ureteral duplication status was unclear. The patient had suffered multiple febrile urinary tract infections throughout her life. Retrograde ureteropyelogram showed a stenotic waist in the upper pole ureter just proximal to the duplex ureteral convergence, and flexible ureteroscopy confirmed a congenital ureteral stricture. Simultaneous robot-assisted laparoscopic and ureteroscopic ureterolithotomy and ureteroplasty were offered and performed using a 3-armed robotic approach. The precise location of the stricture was identified robotically with simultaneous left ureteroscopy. A medial 1.5 cm longitudinal ureterotomy was made through the ureteral stricture to facilitate upper moiety ureterorenoscopy. The calculi were visualized in the upper moiety and retrieved in whole using a stone basket. The calculi were passed via the ureterotomy to the robotic instruments intraperitoneally. The longitudinal ureterotomy was closed transversely. A ureteral stent was placed, and indocyanine green was administered intravenously to confirm good perfusion of the ureteroplasty segment via fluorescence imaging. The stent was removed at 4 weeks. Retrograde ureterography and flexible ureteroscopy revealed complete patency of the anastomosis. At 11 months, the upper pole moiety remained decompressed on ultrasonography. The patient has remained off antibiotic prophylaxis without further infection. Conclusion: Robot-assisted approaches can be primary or adjunct tools in the definitive treatment of pediatric urolithiasis with concomitant urinary tract abnormalities.

背景:儿童尿石症可能与先天性尿路异常并存,使传统的结石治疗方法复杂化。在这里,我们报告了一例机器人辅助腹腔镜和同时输尿管肾盂镜检查对先天性输尿管狭窄患儿尿石症的最终治疗的有效病例。病例介绍:一名3岁女孩就诊时,在左双肾上极轻度扩张处行CT外扫,发现2颗6-7毫米无阻塞结石。输尿管重复状态尚不清楚。患者一生中多次出现发热性尿路感染。逆行输尿管肾盂造影显示在双输尿管汇合处近端输尿管上极有狭窄的腰,输尿管软镜证实为先天性输尿管狭窄。同时提供机器人辅助的腹腔镜和输尿管镜输尿管取石术和输尿管成形术,并使用三臂机器人入路进行。狭窄的精确位置由机器人同时进行左侧输尿管镜检查。经输尿管狭窄行输尿管内侧纵向1.5 cm切开术,方便上段输尿管镜检查。在上半部分可见结石,并使用石筐将其全部取出。结石经输尿管切开术经腹腔输送至机器人器械。纵向输尿管切开术横向闭合。放置输尿管支架,静脉注射吲哚菁绿,通过荧光成像确认输尿管成形术段灌注良好。4周时取出支架。逆行输尿管造影及输尿管软镜显示吻合口完全通畅。11个月时,超声检查显示上极部分减压。患者一直未使用抗生素预防,未发生进一步感染。结论:机器人辅助入路可作为小儿尿石症合并尿路异常的主要或辅助治疗工具。
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引用次数: 2
Endoscopic Closure of a Large Rectovesical Fistula Following Robotic Prostatectomy. 机器人前列腺切除术后大直肠膀胱瘘的内镜闭合。
Q4 Medicine Pub Date : 2020-09-17 eCollection Date: 2020-01-01 DOI: 10.1089/cren.2019.0132
Andrew Watts, Neil J Kocher, Eric Pauli, Jay D Raman

Background: Rectovesical fistulae (RVF) are uncommon complications of pelvic surgeries and are a potential cause of significant morbidity. RVF are not typically closed endoscopically but rather require reoperative surgery of the lower pelvis with closure of tract, interposition of fat or omentum, and possible permanent bowel diversion. We present a unique case of a rectovesical fistula developing after robotic prostatectomy that was managed by multimodal multistage endoscopic therapy as an alternative to conventional operative repair. Case Presentation: A healthy 78-year-old Caucasian man underwent a robot-assisted laparoscopic radical prostatectomy with bilateral pelvic lymph node dissection for high-risk adenocarcinoma of the prostate. The patient's postoperative course was complicated by an unrecognized rectal injury culminating in emergent exploration, abdominal washout, creation of a diverting loop transverse colostomy, and resultant development of a large rectovesical fistula. Given the patient's hostile abdomen and desire for conservative management the fistula was managed through a combined cystoscopic and endoscopic procedure that utilized suturing and clipping to close the fistula. This novel technique was followed by a series of three subsequent endoscopic procedures that enabled us to gradually downsize the fistula over time and ultimately achieve complete closure. The patient's colostomy was eventually reversed with return of bowel continuity. Conclusion: Although uncommon, RVF are significant complications of pelvic surgery. The presence of abdominal/pelvic adhesions from previous surgeries or patient comorbidities can make open surgical repair extremely challenging or impracticable. Therefore, it is important to recognize and consider the use of endoscopic techniques as potential options for closure of rectovesical fistula in certain situations.

背景:直肠膀胱瘘(RVF)是骨盆手术的罕见并发症,是一个潜在的重要原因。裂谷热通常不经内窥镜封闭,而是需要对骨盆下部进行再手术,同时关闭尿路,插入脂肪或网膜,并可能进行永久性肠分流。我们提出了一个独特的病例直肠膀胱瘘发展后,机器人前列腺切除术,是由多模式多阶段的内镜治疗,以替代传统的手术修复。病例介绍:一名健康的78岁白人男性接受了机器人辅助的腹腔镜根治性前列腺切除术,并切除了双侧盆腔淋巴结,以治疗高危前列腺癌。患者的术后过程因未被识别的直肠损伤而复杂化,最终导致紧急探查,腹部冲洗,建立转移环横向结肠造口,并最终形成大的直肠膀胱瘘。考虑到患者的敌对腹部和保守治疗的愿望,我们通过膀胱镜和内窥镜联合手术,利用缝合和夹紧来关闭瘘管。在这项新技术之后,我们进行了一系列的三次内窥镜手术,使我们能够随着时间的推移逐渐缩小瘘管并最终实现完全闭合。患者的结肠造口术最终因肠连续性恢复而逆转。结论:裂谷热虽不常见,但却是骨盆手术的重要并发症。以往手术造成的腹腔/盆腔粘连或患者合并症的存在使得开放式手术修复极具挑战性或不切实际。因此,在某些情况下,认识和考虑使用内窥镜技术作为关闭直肠膀胱瘘的潜在选择是很重要的。
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引用次数: 4
Thermoexpandable Urethral Nickel-Titanium Stent Memokath for Managing Urethral Bulbar Stricture After Failed Urethroplasty. 热扩尿道镍钛支架记忆导管治疗尿道成形术失败后尿道球囊狭窄。
Q4 Medicine Pub Date : 2020-09-17 eCollection Date: 2020-01-01 DOI: 10.1089/cren.2019.0146
Alexey G Martov, Olga Al Plekhanova, Dmitry V Ergakov, Nikolay A Baykov

Introduction: Urethral stenting became popular two decades ago, but nowadays its frequency is slightly decreased because of the rising application of urethroplasty. Today urethral stenting is reserved only for failure after urethral reconstruction or in cases when the plastic surgery is unfavorable. The Memokath stent (Pnn Medical A/S, Kvistgaard, Denmark) is manufactured from a biocompatible alloy of nickel and titanium and known to be the most popular in this field. Case Description: A 38-year-old man with a history of 9 years Memokath urethral stenting was admitted to our clinic with obstructive lower urinary tract symptoms. The indication for Memokath stenting was repeated recurrences after endoscopic and reconstructive operations. The plain radiography showed a normal position of the stent and only the endoscopic examination revealed its total calcification. New superpulse thulium fiber laser has been used to free the stent from the stones and safely remove it without additional urethral injury. Results: The postoperative time was within normal limits, the catheter was removed on the fourth day after operation. Three months follow-up was without stricture recurrence. We continue active surveillance of the patient. Conclusion: The calcification of the stent could be properly diagnosed endoscopically; the Memokath stent could be safely removed in 9 years after implantation; thulium fiber laser is effective and safe in the management of encrusted urethral stent.

导言:尿道支架置入术在二十年前开始流行,但现在由于尿道成形术的应用增加,其频率略有下降。如今,尿道支架置入术仅用于尿道重建失败或不宜进行整形手术的情况。Memokath支架(Pnn Medical A/S, Kvistgaard, Denmark)由镍和钛的生物相容性合金制成,是该领域最受欢迎的支架。病例描述:一名38岁男性,有9年Memokath尿道支架置入术史,因下尿路梗阻性症状入院。Memokath支架植入术的适应症是内镜和重建手术后反复复发。x线平片显示支架位置正常,只有内镜检查显示其完全钙化。新型超脉冲铥光纤激光已被用于将支架从结石中解放出来,并在不增加尿道损伤的情况下安全地将其移除。结果:术后时间均在正常范围内,于术后第4天拔除导管。随访3个月无狭窄复发。我们将继续对病人进行积极监测。结论:内窥镜下支架钙化可以正确诊断;Memokath支架植入后9年内可安全取出;铥光纤激光治疗尿道支架结痂安全有效。
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引用次数: 2
Primary Bladder Neck Obstruction in a Young Woman: A Novel Technique of Bladder Neck Incision Using Holmium Laser. 年轻女性原发性膀胱颈梗阻:钬激光膀胱颈切开新技术。
Q4 Medicine Pub Date : 2020-09-17 eCollection Date: 2020-01-01 DOI: 10.1089/cren.2019.0172
Pankaj Panwar, Devanshu Bansal, Rakhul Lekha Raveendran, Anant Kumar

Background: Management of primary bladder neck obstruction (PBNO) in women is difficult. Surgical treatment in the form of bladder neck incision (BNI) is indicated in many cases. There is no defined consensus on the best surgical technique of BNI in women. We present a novel technique of BNI in such cases using pediatric cystoscope and holmium laser, which is a promising alternative to the existing management techniques. Case Presentation: A 28-year-old lady complained of obstructive lower urinary tract symptoms. Serum biochemistry revealed azotemia. Further investigation utilizing a micturating cystourethrogram showed a closed bladder neck, and urodynamic studies revealed a high bladder outlet obstruction index suggestive of PBNO. BNI was effectively performed using pediatric cystoscope and holmium laser at 3, 9, and 12 o'clock positions. Postoperatively the patient had improving renal function and clinical improvement. Conclusion: Use of pediatric cystoscope with holmium laser for BNI in females is a novel technique that offers the advantage of higher maneuverability in the female urethra, precise incision with protection of external sphincter from thermal damage, and avoidance of the complication of vesicovaginal fistula caused by posterior incisions.

背景:女性原发性膀胱颈梗阻(PBNO)的治疗是困难的。膀胱颈切开(BNI)是许多病例的手术治疗方法。对于女性BNI的最佳手术技术尚无明确的共识。我们提出了一种使用儿童膀胱镜和钬激光治疗此类病例的新技术,这是现有治疗技术的一种有希望的替代方法。病例介绍:一位28岁的女性主诉下尿路梗阻性症状。血清生化显示氮血症。利用排尿膀胱尿道造影进一步检查显示膀胱颈部闭合,尿动力学研究显示膀胱出口阻塞指数高提示PBNO。采用小儿膀胱镜和钬激光在3点、9点和12点位置进行BNI有效。术后患者肾功能改善,临床改善。结论:钬激光儿童膀胱镜治疗女性BNI是一种新颖的技术,在女性尿道内具有较高的可操作性,切口精确,保护外括约肌免受热损伤,避免后切口引起膀胱阴道瘘的并发症。
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引用次数: 0
Deceived by a CT Scan: The Case of the Misrepresented Stone Size. 被CT扫描欺骗:谎报结石大小的案例。
Q4 Medicine Pub Date : 2020-09-17 eCollection Date: 2020-01-01 DOI: 10.1089/cren.2019.0127
Emma Rosenbluth, Ryan Chandhoke, Daniel C Rosen, Jacob N Bamberger, Mantu Gupta

Background: CT has become the gold standard for radiographic evaluation of urolithiasis. CT is highly sensitive for detecting kidney stones and provides valuable information regarding stone size, composition, location, and overall stone burden. Although CT can provide reliable estimations of stone size, we have encountered an instance in which it can be deceiving. Motion artifact in CT images can cause a warping distortion effect that makes renal stones appear larger than they actually are. Case Presentation: We describe a case of a 37-year-old woman with a history of kidney stones and obesity presenting with intermittent flank pain and gross hematuria, found to have a large lower pole renal calculus that appeared deceptively large on CT imaging. Given the apparent size and location of the stone, the patient was counseled and consented for a percutaneous nephrolithotomy (PCNL). Although the stone was initially suspected to be >2 cm based on the preoperative CT scan, intraoperative pyelography revealed a much smaller than expected radio-dense stone. The patient was stone free after PCNL without any immediate postoperative complications. However, her course was later complicated by delayed bleeding causing significant clot hematuria, perinephric hematoma, and reactive pleural effusion. Conclusion: Although CT is especially valuable in preparing for surgery based on its ability to outline collecting system anatomy, it is important to remember that it can be deceiving. Correlation with kidney, ureter, and bladder radiograph and ultrasound is critical to understanding the clinical case and planning the optimal surgical approach.

背景:CT已成为尿石症影像学评价的金标准。CT对肾结石的检测非常敏感,可以提供有关结石大小、组成、位置和总体结石负担的宝贵信息。虽然CT可以提供可靠的结石大小估计,但我们遇到过它可能具有欺骗性的情况。CT图像中的运动伪影会引起扭曲变形,使肾结石看起来比实际大。病例介绍:我们描述了一个37岁的女性,有肾结石和肥胖的病史,表现为间歇性的腹部疼痛和肉眼血尿,发现有一个很大的下极肾结石,在CT成像上看起来很大。鉴于结石的明显大小和位置,建议患者接受经皮肾镜取石术(PCNL)。虽然根据术前CT扫描,最初怀疑结石> 2cm,但术中肾盂造影显示结石比预期的小得多。PCNL术后患者无结石,无术后并发症。然而,她的病程后来因迟发性出血而复杂化,引起明显的血块性血尿、肾周血肿和反应性胸腔积液。结论:尽管CT在准备手术时特别有价值,因为它能够勾勒出收集系统的解剖结构,但重要的是要记住它可能是欺骗性的。与肾脏、输尿管、膀胱x线片和超声的相关性对了解临床病例和计划最佳手术入路至关重要。
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引用次数: 0
Successful Pregnancy Outcomes After Laparoscopic Management of Pheochromocytoma. 腹腔镜治疗嗜铬细胞瘤后妊娠成功的结局。
Q4 Medicine Pub Date : 2020-09-17 eCollection Date: 2020-01-01 DOI: 10.1089/cren.2019.0139
Pradeep Prakash, Vidushi Kulshrestha, Rashmi Ramachandran, Rajeev Kumar

Background: Pheochromocytoma is a rare cause of hypertension in pregnancy, which is often overlooked; especially in late pregnancy because of more prevalent pre-eclampsia. It has been associated with significant morbidity and mortality rates in both mother and fetus, if not diagnosed and treated in time. Minimally invasive surgery has been infrequently used for surgical management of pheochromocytoma in pregnancy, with <20 reported cases in English literature. Case Presentation: A 26-year-old pregnant woman presented at 9 weeks of gestation with complaints of palpitations, sweating, and headache; with past history of first trimester spontaneous abortion caused by accelerated hypertension. She was found to have hypertension and diabetes, but no pedal edema, weight gain, or proteinuria. Ultrasonogram and MRI of abdomen revealed a left adrenal mass and 24 hours urinary catecholamines levels were increased, suggesting a pheochromocytoma. After preoperative optimization in consultations with obstetricians, endocrinologists, and anesthetists, she underwent laparoscopic left adrenalectomy during 15th week of gestation. Perioperative hospital course was uneventful for both mother and the fetus. After adrenalectomy, her diabetes was cured and hypertension was controlled with single antihypertensive. She was readmitted at 31 weeks of gestation with accelerated hypertension and underwent emergency caesarean for impending eclampsia at 32 weeks, and delivered a healthy female baby. 131I-meta-iodobenzylguanidine (MIBG) scan and 68Ga-[1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid]-1-NaI(3)-octreotide positron emission tomography-CT (68Ga-DOTANOC PET-CT) scan was obtained in postpartum period to rule out any extra-adrenal pheochromocytoma, both of which did not reveal any abnormality. At 1 year follow-up, she is normoglycemic and hypertension controlled on single antihypertensive. Conclusion: Pheochromocytoma in pregnancy is a rare but potentially lethal condition, and high index of suspicion is required for early diagnosis. Multidisciplinary coordination is required for effective management of this rare condition. Laparoscopic adrenalectomy is safe in second trimester of pregnancy for both mother and fetus.

背景:嗜铬细胞瘤是妊娠期高血压的罕见病因,常被忽视;尤其是在怀孕后期因为先兆子痫更普遍。如果不及时诊断和治疗,它与母亲和胎儿的显著发病率和死亡率有关。微创手术很少用于妊娠期嗜铬细胞瘤的手术治疗,病例介绍:一位26岁的孕妇在妊娠9周时出现心悸、出汗和头痛的主诉;既往有妊娠早期因高血压加速引起的自然流产史。她被发现有高血压和糖尿病,但没有脚水肿、体重增加或蛋白尿。腹部超声及MRI示左侧肾上腺肿块,24小时尿儿茶酚胺水平增高,提示嗜铬细胞瘤。在与产科医生、内分泌学家和麻醉师进行术前优化咨询后,她在妊娠第15周接受了腹腔镜左肾上腺切除术。围手术期的住院过程对母亲和胎儿都很顺利。肾上腺切除术后,糖尿病治愈,高血压得到控制。她在妊娠31周时因高血压加速再次入院,并在32周时因即将发生子痫而紧急剖腹产,并生下了一个健康的女婴。产后进行131i -间碘苄基胍(MIBG)扫描和68Ga-[1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸]-1- nai(3)-奥曲肽正电子发射断层扫描(68Ga- dotanoc PET-CT)扫描,排除肾上腺外嗜铬细胞瘤,均未发现异常。随访1年,患者血糖正常,单药降压药控制高血压。结论:妊娠期嗜铬细胞瘤是一种罕见但具有潜在致命性的疾病,早期诊断需要高度的怀疑指数。多学科协作是有效治疗这种罕见疾病的必要条件。腹腔镜肾上腺切除术在妊娠中期对母亲和胎儿都是安全的。
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引用次数: 2
Percutaneous Endoscopic Treatment of Complicated Delayed Bleeding Postpercutaneous Nephrolithotomy: A Novel Suggestion. 经皮肾镜取石术后并发迟发性出血的内镜治疗:一项新建议。
Q4 Medicine Pub Date : 2020-09-17 eCollection Date: 2020-01-01 DOI: 10.1089/cren.2019.0091
Akbar Nouralizadeh, Arsalan Aslani, Iman Ghanaat, Milad Bonakdar Hashemi

Background: Delayed bleeding after percutaneous nephrolithotomy (PCNL), which may occur within the first 3 weeks postoperatively, is a life-threatening complication that may result from arteriovenous fistula and arterial pseudoaneurysm. Angioembolization is the standard treatment when these patients develop hemodynamic instability despite conservative measures. Contrast hypersensitivity and renal insufficiency, however, contraindicate angiogram and subsequent embolization; in these patients, alternative methods such as the one described in this study may help in resolving the renal hemorrhage. Case Presentation: In this case series, we report the effective management of post-PCNL hemorrhage with nephroscopy and nephrostomy and drainage and tamponade because angioembolization was not feasible. Conclusion: Delayed bleeding after PCNL may be managed conservatively with nephrostomy drainage and tamponade when angioembolization is not feasible.

背景:经皮肾镜取石术(PCNL)后迟发性出血可能在术后3周内发生,是危及生命的并发症,可能由动静脉瘘和动脉假性动脉瘤引起。当这些患者出现血流动力学不稳定时,血管栓塞是标准的治疗方法,尽管采取了保守措施。然而,造影剂过敏和肾功能不全,禁忌血管造影和随后的栓塞;在这些患者中,本研究中描述的替代方法可能有助于解决肾出血。病例介绍:在本病例系列中,我们报告了由于血管栓塞术不可行的pcnl后出血的有效治疗,肾镜和肾造口术以及引流和填塞。结论:当不能进行血管栓塞术时,可采用肾造口引流和压塞术保守处理PCNL后的迟发性出血。
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引用次数: 3
Endoscopic Treatment of Complete Ureterointestinal Stenosis Without Antegrade Ureteroscopy. 不经顺行输尿管镜的完全性输尿管肠狭窄的内镜治疗。
Q4 Medicine Pub Date : 2020-09-17 eCollection Date: 2020-01-01 DOI: 10.1089/cren.2020.0026
Jorge Panach-Navarrete, Rocío Tonazzi-Zorrilla, José María Martínez-Jabaloyas

Background: Ureterointestinal stenosis is a frequent complication after radical cystectomy, occurring in up to 10%-12% of cases. Endoscopic treatment of complete stenosis has been described through double access, with antegrade flexible ureteroscopy and simultaneous retrograde endoscopy through the intestinal diversion. We present a case of endoscopic treatment without use of antegrade ureteroscopy. Case Presentation: A 52-year-old man underwent surgery for peritoneal carcinomatosis secondary to mucinous adenocarcinoma. Ileocecal resection, omentectomy, sigmoidectomy, rectal resection, cystoprostatectomy, and ileal duct were performed. He had a complicated postoperative period because of enterocutaneous fistulas, peritonitis, and secondary intention wall closure, needing multiple surgeries. Four months later, he was diagnosed with left ureteroinestinal stenosis, for which endoscopic management was the chosen treatment. Intraoperative diagnosis was complete stenosis. To locate the stenosis, methylene blue was instilled using a percutaneous ureteral catheter. With a resectoscope inserted through the ileal duct, the stenosis was observed and opened using cold knife and Collins knife. The stenosis was resolved satisfactorily. Conclusion: Endoscopic management of complete ureterointestinal stenosis is a viable treatment option. Although stenosis localization has previously been described with two endoscopes using transillumination, we demonstrate another localization technique using methylene blue.

背景:输尿管肠狭窄是根治性膀胱切除术后常见的并发症,发生率高达10%-12%。内镜下治疗完全性狭窄已被描述为通过双通道,顺行柔性输尿管镜和同时逆行经肠分流的内镜。我们提出一个病例的内镜治疗不使用顺行输尿管镜。病例介绍:一名52岁男性因黏液腺癌继发腹膜癌接受手术治疗。行回盲切除术、大网膜切除术、乙状结肠切除术、直肠切除术、膀胱前列腺切除术、回肠导管切除术。由于肠皮瘘、腹膜炎和继发性意图壁关闭,他有一个复杂的术后时期,需要多次手术。4个月后,他被诊断为左输尿管狭窄,选择内镜治疗。术中诊断为完全性狭窄。为了定位狭窄,经皮输尿管导管灌注亚甲基蓝。切除镜经回肠导管插入,观察狭窄,用冷刀和柯林斯刀切开。狭窄得到了满意的解决。结论:内镜下治疗完全输尿管狭窄是一种可行的治疗方法。虽然狭窄的定位以前已经描述了两个内窥镜使用透照,我们展示了另一种定位技术,使用亚甲基蓝。
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引用次数: 2
Tamsulosin-Induced Priapism: Report of Two Cases and Review of Literature. 坦索罗辛致阴茎勃起障碍2例报告并文献复习。
Q4 Medicine Pub Date : 2020-09-17 eCollection Date: 2020-01-01 DOI: 10.1089/cren.2019.0157
Usama Khater, Ranjith Ramasamy, Hemendra N Shah

Background: Tamsulosin in a widely used drug in urology practice in treating lower urinary tract symptoms of benign prostatic hyperplasia, distal ureteral stones, and ureteral stent-related symptoms. Ischemic priapism is a rare but serious adverse effect of tamsulosin. We report two cases of tamsulosin-induced priapism and reviewed available literature citing priapism as a complication of tamsulosin. We also reviewed the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS) database to identify reported cases of tamsulosin-induced priapism. Case Presentation: First patient was a 61-year-old African American male with paraplegia of 30-year duration. He developed priapism after taking first dose of tamsulosin for lower urinary tract symptoms. He presented with 18 hours of painful erection and was treated with aspiration and irrigation, followed by phenylephrine injection. The patient maintained potency after treatment. The second patient was a 24-year-old male who received tamsulosin in the emergency department as medical expulsive therapy for 11 mm distal ureteral stone. Since he had intractable pain, he underwent emergency primary ureteroscopy with laser lithotripsy as definitive treatment of his ureteral calculus. He developed intraoperative priapism that subsided postoperatively. However, he was discharged with tamsulosin to reduce stent-related urinary symptoms. He returned back to the emergency department after 3 days with persistent priapism for 3 days and needed penoscrotal corporeal decompression to treat his priapism. At 6 weeks follow-up visit, the patient has lost his potency. Although there were only 4 case reports on review of the literature, we were able to identify 46 cases reported in the U.S. FAERS database. Conclusion: Priapism can be an adverse reaction to tamsulosin. Providers and patients should be aware about this complication to ensure early seeking of management to avoid devastating outcomes, particularly in young patients when tamsulosin is given as medical expulsive therapy for ureteral stone and stent-related symptoms.

背景:坦索罗辛是泌尿外科实践中广泛使用的药物,用于治疗良性前列腺增生、输尿管远端结石和输尿管支架相关症状的下尿路症状。缺血性勃起功能障碍是坦索罗辛罕见但严重的不良反应。我们报告了两例坦索罗辛引起的阴茎勃起障碍,并回顾了坦索罗辛引起阴茎勃起障碍的现有文献。我们还回顾了美国食品和药物管理局不良事件报告系统(FAERS)数据库,以确定坦索罗辛诱发的勃起功能障碍的报告病例。病例介绍:第一位患者为61岁非裔美国男性,截瘫30年。他在服用第一剂坦索罗辛治疗下尿路症状后出现阴茎勃起。患者出现疼痛勃起18小时,接受抽吸和冲洗治疗,随后注射苯肾上腺素。病人经治疗后仍保持效力。第二例患者为24岁男性,因输尿管远端结石11mm,在急诊科接受坦索罗辛医学排出治疗。由于他有顽固性疼痛,他接受了紧急输尿管镜检查和激光碎石作为输尿管结石的最终治疗。术中出现阴茎勃起,术后消退。然而,他出院时使用坦索罗辛以减少支架相关的泌尿系统症状。3天后因持续阴茎勃起3天返回急诊科,需行阴茎减压术治疗其阴茎勃起。随访6周,患者效力丧失。虽然在文献回顾中只有4例病例报告,但我们能够在美国FAERS数据库中确定46例报告。结论:坦索罗辛可能是阴茎勃起的不良反应。提供者和患者应意识到这一并发症,以确保尽早寻求治疗,以避免破坏性后果,特别是在年轻患者中,当输尿管结石和支架相关症状被作为医学排出疗法给予坦索罗辛时。
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引用次数: 5
Endourologic Treatment in Two Cases of Ureteral Valves. 输尿管瓣膜的腔内治疗2例。
Q4 Medicine Pub Date : 2020-09-17 eCollection Date: 2020-01-01 DOI: 10.1089/cren.2019.0186
Beatriz Fernández-Bautista, Jose María Angulo, Rubén Ortiz, Laura Burgos, Javier Ordóñez, Alberto Parente

Introduction: Congenital ureteral valves are a rare cause of ureteral obstruction that may lead to renal function deterioration. We present two clinical cases treated endoscopically by monopolar electrocautery and laser fiber ablation. Presentation of Case: The first case is a 13-year-old male with several episodes of abdominal pain and was found to have severe left hydronephrosis. Ultrasonography showed a dilated ureter and pelvicaliceal system with an obstructive renogram curve. We performed a retrograde pyelogram, finding a dilated ureter 5 cm up from the vesicoureteral junction with ureteral valves in that place. Ablation of the valves was conducted using monopolar electrocautery. The second case is a 2-year-old male with left ureterohydronephrosis shown in abdominal ultrasonography. In the radiologic findings, a high-risk pyelocaliceal dilatation with renal parenchyma thinning and a diameter of 3.3 cm for the left ureter is described, with an obstructive renogram. We performed a cystoscopy, observing the presence of valves in the ureter at 3 cm that conditioned an obstruction. The complete section of the valves was performed through a 270μm holmium laser fiber. Our patients made an uneventful postoperative recovery and continue to remain completely asymptomatic. A significant decrease in renal dilation was observed and renal function recovered in both cases. Conclusion: Ureteral valves are an uncommon cause of ureteral obstruction. Advances in endourologic techniques allow us to give a minimally invasive approach to these diseases, obtaining good long-term results in our small series of patients.

导读:先天性输尿管瓣膜是一种罕见的输尿管梗阻,可能导致肾功能恶化。我们报告两例内镜下单极电灼和激光纤维消融治疗的临床病例。病例表现:第一个病例是一名13岁男性,有几次腹痛,发现有严重的左侧肾积水。超声显示输尿管和盆腔系统扩张,肾图曲线梗阻。我们做了一个逆行肾盂造影,在膀胱输尿管连接处5厘米处发现一个扩张的输尿管,在那个地方有输尿管瓣膜。用单极电灼法对阀门进行烧蚀。第二例为2岁男性,腹部超声显示左侧输尿管积水。影像学表现为左输尿管肾盂局部扩张伴肾实质变薄,直径3.3 cm,伴有梗阻性肾造影。我们进行了膀胱镜检查,观察到输尿管3厘米处存在瓣膜,这是梗阻的条件。通过270μm钬激光光纤对阀门进行完整切片。我们的患者术后恢复顺利,并继续保持完全无症状。两例患者肾脏扩张明显减少,肾功能恢复。结论:输尿管瓣膜是一种罕见的输尿管梗阻原因。泌尿系统技术的进步使我们能够对这些疾病进行微创治疗,在我们的小系列患者中获得良好的长期效果。
{"title":"Endourologic Treatment in Two Cases of Ureteral Valves.","authors":"Beatriz Fernández-Bautista,&nbsp;Jose María Angulo,&nbsp;Rubén Ortiz,&nbsp;Laura Burgos,&nbsp;Javier Ordóñez,&nbsp;Alberto Parente","doi":"10.1089/cren.2019.0186","DOIUrl":"https://doi.org/10.1089/cren.2019.0186","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> Congenital ureteral valves are a rare cause of ureteral obstruction that may lead to renal function deterioration. We present two clinical cases treated endoscopically by monopolar electrocautery and laser fiber ablation. <b><i>Presentation of Case:</i></b> The first case is a 13-year-old male with several episodes of abdominal pain and was found to have severe left hydronephrosis. Ultrasonography showed a dilated ureter and pelvicaliceal system with an obstructive renogram curve. We performed a retrograde pyelogram, finding a dilated ureter 5 cm up from the vesicoureteral junction with ureteral valves in that place. Ablation of the valves was conducted using monopolar electrocautery. The second case is a 2-year-old male with left ureterohydronephrosis shown in abdominal ultrasonography. In the radiologic findings, a high-risk pyelocaliceal dilatation with renal parenchyma thinning and a diameter of 3.3 cm for the left ureter is described, with an obstructive renogram. We performed a cystoscopy, observing the presence of valves in the ureter at 3 cm that conditioned an obstruction. The complete section of the valves was performed through a 270μm holmium laser fiber. Our patients made an uneventful postoperative recovery and continue to remain completely asymptomatic. A significant decrease in renal dilation was observed and renal function recovered in both cases. <b><i>Conclusion:</i></b> Ureteral valves are an uncommon cause of ureteral obstruction. Advances in endourologic techniques allow us to give a minimally invasive approach to these diseases, obtaining good long-term results in our small series of patients.</p>","PeriodicalId":36779,"journal":{"name":"Journal of Endourology Case Reports","volume":"6 3","pages":"213-216"},"PeriodicalIF":0.0,"publicationDate":"2020-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/cren.2019.0186","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38534284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Journal of Endourology Case Reports
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