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Proceedings of IEEE Sensors 2003 (IEEE Cat. No.03CH37498)最新文献

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A new method for label-free imaging of biomolecular interactions 生物分子相互作用无标记成像的新方法
Pub Date : 2003-12-01 DOI: 10.1109/ICSENS.2003.1278948
Peter Li, Bo Lin, J. Gerstenmaier, Brian T Cunningham
A new method for producing label-free high-resolution images of biomolecular binding to the surface of a biosensor is demonstrated. The biosensor incorporates a guided mode resonance filter that, when illuminated with white light, is designed to reflect only a narrow band of wavelengths where the reflected wavelength is tuned by the adsorption of biological material onto the sensor surface. In this work, an instrument is used to acquire spatial maps of the resonant reflected wavelength in order to produce images of bound biomolecule patterns as applied by a microarray spotter. The biosensor imaging capability is expected to yield applications in pharmaceutical compound screening, genomics, proteomics, and molecular diagnostics, where there is a need to screen large numbers of biochemical interactions against samples using low volumes of reagents.
一种新的方法来产生无标签的高分辨率图像的生物分子结合到生物传感器的表面。该生物传感器集成了一个引导模式共振滤波器,当被白光照射时,该滤波器被设计成只反射一个窄波段的波长,其中反射波长通过生物材料在传感器表面的吸附而调整。在这项工作中,一种仪器被用来获取共振反射波长的空间图,以便产生结合生物分子模式的图像,应用于微阵列观察者。生物传感器成像能力有望在药物化合物筛选、基因组学、蛋白质组学和分子诊断方面产生应用,这些领域需要使用少量试剂对样品进行大量生化相互作用筛选。
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引用次数: 103
Real-time detection of bacteria spores using a QCM based immunosensor 利用基于QCM的免疫传感器实时检测细菌孢子
Pub Date : 2003-10-22 DOI: 10.1109/ICSENS.2003.1279134
Sang-Hun Lee, D. Stubbs, J. Cairney, W. Hunt
In this paper we present evidence of detection of B. subtilis (non-pathogene models for B. anthracis) spores using a real-time, dual QCM (quartz crystal microbalance) immuno-sensing system. Device sensitivity is achieved through the use of a 10 MHz AT-cut quartz crystal operating in an enclosed flowcell. Specificity is maintained through the use of an immuno-sensing layer consisting of monoclonal antibodies specific to a single Bacillus species. The fidelity of both sensing parameters is ensured by the presence in our system of a reference device coated with an antibody that is not specific for the target antigen. Associating the QCM response signature with the specific binding of a particular species of Bacillus spore to an antibody has implications for future identification of pathogenic endospores such as B. anthracis.
在本文中,我们提出了使用实时、双QCM(石英晶体微天平)免疫传感系统检测枯草芽孢杆菌(炭疽芽孢杆菌的非致病模型)孢子的证据。通过在封闭的液池中使用10mhz at切割石英晶体来实现器件灵敏度。特异性是通过使用由单克隆抗体组成的免疫感应层来维持的,该抗体对单个芽孢杆菌物种具有特异性。这两个传感参数的保真度是通过在我们的系统中存在一个覆盖了对目标抗原不特异性的抗体的参比装置来保证的。将QCM反应特征与特定种类芽孢杆菌孢子与抗体的特异性结合联系起来,对未来鉴定致病性内生孢子(如炭疽芽孢杆菌)具有重要意义。
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引用次数: 8
Orthogonal fluxgate magnetometer utilizing bias switching for stable operation 采用偏置开关的正交磁通门磁强计,工作稳定
Pub Date : 2003-10-22 DOI: 10.1109/ICSENS.2003.1278982
I. Sasada, T. Usui
A new mode of operation is described for an orthogonal fluxgate built with a thin magnetic wire. In this mode, a dc bias is added to the ac excitation and the fundamental component of the induced voltage is a measure of the axially applied magnetic field. A bias switching method for reducing offset and drift is proposed for the orthogonal fluxgate operating in the new mode. Preliminary results on the resolution and the stability are presented.
介绍了用细磁丝构成正交磁通门的一种新的工作方式。在这种模式下,在交流励磁上加一个直流偏置,感应电压的基本分量是对轴向施加磁场的测量。针对工作在新模式下的正交磁通门,提出了一种减小偏置和漂移的偏置开关方法。给出了分辨率和稳定性的初步结果。
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引用次数: 5
Micromechanical device for the measurement of the RMS value of high-frequency voltages 用于测量高频电压均方根值的微机械装置
Pub Date : 2003-10-22 DOI: 10.1109/ICSENS.2003.1279014
S. Beißner, A. Wogersien, S. Buttgenbach, T. Schrader, U. Stumper
In this paper we present a new device for the measurement of the root-mean square (rms) value of high frequency (HF) voltages. The device is realized as a micromachined structure which responds to electrostatic forces caused by applied voltages. The structure has a seesaw-like geometry and is made of silicon. At frequencies much higher than the mechanical resonance frequency the system will not follow the stimulating sinusoidal waveform any more, but it is deflected according to the rms value of the HF voltage. The deflection can be determined by a wheatstone bridge consisting of two on-chip capacitors and two external resistors or by measuring a single capacitor.
本文提出了一种测量高频电压均方根值的新装置。该装置被实现为一个微机械结构,它响应由外加电压引起的静电力。该结构具有类似跷跷板的几何形状,由硅制成。在远高于机械谐振频率的频率下,系统不再遵循激励正弦波形,而是根据高频电压的均方根值发生偏转。挠度可以通过由两个片上电容器和两个外部电阻组成的惠斯通电桥或通过测量单个电容器来确定。
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引用次数: 5
Two-channel inclinometer based on low-coherence fiber-optic Mach-Zehnder interrogation technique 基于低相干光纤马赫-曾德尔讯问技术的双通道测斜仪
Pub Date : 2003-10-22 DOI: 10.1109/ICSENS.2003.1278924
Libo Yuan
A two-channel inclinometer based on the gravity-referenced rotation fiber optic sensing system is demonstrated. It measures the angle variations between a nominally vertical reference line in the civil structure and the direction of gravity. By using low-coherence fiber optic Mach-Zehnder interferometric technique, the rotations sensitivity in the two perpendicular vertical planes can be achieved in the 0.2' with the dynamics range of /spl plusmn/5/spl deg/.
介绍了一种基于重力参考旋转光纤传感系统的双通道测斜仪。它测量土木结构中名义上垂直的参考线与重力方向之间的角度变化。采用低相干光纤Mach-Zehnder干涉技术,可在0.2'范围内实现两个垂直垂直平面内的旋转灵敏度,动态范围为/spl + /5/spl度/。
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引用次数: 0
Chromium doped phosphor based fiber-optic thermometer 基于掺铬磷光体的光纤温度计
Pub Date : 2003-10-22 DOI: 10.1109/ICSENS.2003.1278902
H. Aizawa, E. Toba, T. Katsumata, S. Komuro, T. Morikawa
A variety of chromium (Cr/sup 3+/) doped phosphors has been studied for a sensor head materials in the fiber-optic thermometer, have been studied. Cr doped alumina (Cr:Al/sub 2/O/sub 3/), spinel (Cr:MgAl/sub 2/O/sub 4/) and yttrium ortho-aluminate (Cr:YAlO/sub 3/) crystals are grown using floating zone (FZ) technique. The value and temperature coefficient of photoluminescence (PL) lifetime are evaluated using the fiberoptic thermometer equipment. The value and temperature coefficient of PL lifetime vary greatly with the host materials. Among them, perovskite type Cr:YAlO/sub 3/ crystal shows the longest PL lifetime and the largest temperature coefficient. Cr doped YAlO/sub 3/ crystal is a potentially useful sensor material for fiber-optic thermometer due to long PL lifetime and large temperature coefficient of PL lifetime.
研究了多种铬(Cr/sup 3+/)掺杂荧光粉作为光纤温度计传感器头的材料。采用浮区(FZ)技术制备了Cr掺杂氧化铝(Cr:Al/sub 2/O/sub 3/)、尖晶石(Cr:MgAl/sub 2/O/sub 4/)和正铝酸钇(Cr:YAlO/sub 3/)晶体。利用光纤测温仪测量了光致发光寿命值和温度系数。PL寿命值和温度系数随基体材料的不同变化很大。其中,钙钛矿型Cr:YAlO/sub 3/晶体的PL寿命最长,温度系数最大。Cr掺杂YAlO/sub - 3/晶体具有发光寿命长、发光寿命温度系数大的特点,是一种有潜力的光纤温度计传感器材料。
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引用次数: 0
An optical fiber pH sensor based on the electrostatic self-assembly method 一种基于静电自组装方法的光纤pH传感器
Pub Date : 2003-10-22 DOI: 10.1109/ICSENS.2003.1278907
F. Arregui, I. Latasa, I. Matías, R. Claus
A new type of optical fiber pH sensors has been fabricated using the electrostatic self-assembly (ESA) method. The device is based on the co-deposition of the polymer poly(allylamine hydrochloride) and the colorimetric pH indicator neutral red as the cationic monolayers, and the polymer polyfacrylic acid) that conforms the anionic monolayers. The coatings are built up monolayer by monolayer on the ends of standard communications optical fibers with a thickness of 9 nanometers per bilayer. The final structure of the coating is a homogeneous film that forms a nanoFabry-Perot interferometer. The sensing mechanism of the sensor relies on changes in the spectral response of the coating with the variations of pH. The range of measurement goes from pH 5 to 8.
采用静电自组装(ESA)方法制备了一种新型光纤pH传感器。该装置是基于聚合物聚(盐酸烯丙胺)与比色pH指示剂中性红共沉积为阳离子单层,聚合物聚丙烯酸(聚丙烯酸)为阴离子单层。这种涂层是在标准通信光纤的两端一层一层地建立起来的,每层厚度为9纳米。涂层的最终结构是形成纳米法布里-珀罗干涉仪的均匀薄膜。传感器的传感机理依赖于涂层的光谱响应随pH值变化的变化,测量范围为pH值5 ~ 8。
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引用次数: 14
An innovative approach to gas sensing using carbon nanotubes thin films: sensitivity, selectivity and stability response analysis 一种利用碳纳米管薄膜进行气体传感的创新方法:灵敏度、选择性和稳定性响应分析
Pub Date : 2003-10-22 DOI: 10.1109/ICSENS.2003.1278972
C. Cantalini, L. Valentini, I. Armentano, J. Kenny, L. Lozzi, S. Santucci
We report that carbon nanotubes (CNTs) thin films have been successfully prepared as new NO/sub 2/ and H/sub 2/ gas sensors in the NO/sub 2/ concentration range 7 ppb - 7 ppm and H2 8.5ppm - 850 ppm respectively. 150 nm thick CNTs thin films, have been prepared by rf-PECVD on Si/Si/sub 3/N/sub 4/ substrates, provided with Pt interdigital sputtered electrodes, and post-annealed under controlled conditions. The electrical response has been investigated at different operating temperatures and gases over a period of 6 months. Sensitivity response analysis has demonstrated that CNTs are more responsive to NO/sub 2/ than H/sub 2/. By selecting suitable annealing conditions, the microstructure significantly changes enabling: to adjust the base line resistance of the film (i.e. the resistance in dry air) from 100 Ohms to several mega-Ohms, and to improve gas sensitivity. Selectivity test have highlighted negligible cross sensitivity effects to the detection of NO/sub 2/, when H/sub 2/ is the interfering gas. Long term stability test have shown a neglegible increase of the base line resistance and an improvement of the NO/sub 2/ sensitivity.
在NO/ sub2 /浓度为7ppb ~ 7ppm和H2为8.5ppm ~ 850ppm的条件下,成功制备了新型NO/ sub2 /和H/ sub2 /气体传感器。采用rf-PECVD在Si/Si/sub / 3/N/sub / 4/衬底上制备了150 nm厚的CNTs薄膜,并在控制条件下进行后退火。在6个月的时间里,研究了不同工作温度和气体下的电响应。灵敏度响应分析表明,CNTs对NO/sub 2/的响应比H/sub 2/的响应更灵敏。通过选择合适的退火条件,微观结构发生了显著变化,使薄膜的基线电阻(即干燥空气中的电阻)从100欧姆调整到几兆欧姆,并提高了气体灵敏度。选择性试验表明,当H/sub 2/为干扰气体时,对NO/sub 2/的交叉灵敏度可以忽略不计。长期稳定性试验表明,基线电阻的增加可以忽略不计,而NO/sub 2/灵敏度的提高可以忽略不计。
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引用次数: 9
High sensitivity vertical Hall sensor integrated with SOI CMOS 高灵敏度垂直霍尔传感器集成了SOI CMOS
Pub Date : 2003-10-22 DOI: 10.1109/ICSENS.2003.1278934
A. Peczalski, D. Berndt, D. Sandquist
We present the design and performance of the gated vertical Hall sensor integrated with silicon on insulator (SOI) complementary metal oxide semiconductor (CMOS) integrated circuits. We demonstrated almost a factor of ten improvement in sensitivity over the comparable vertical Hall sensor integrated on bulk CMOS i.e. constant voltage and constant current sensitivity of 1200 V/V*T versus 130 V/V*T and 200mV/A*T versus 23 mV/A*T respectively. The high sensitivity is probably related to the inherent amplification mechanism in the gated structure. We offer our interpretation of the physical principles of the built in gain and its dependence on bias conditions.
本文介绍了一种基于硅绝缘体互补金属氧化物半导体(CMOS)集成电路的门控垂直霍尔传感器的设计和性能。我们展示了与集成在块体CMOS上的同类垂直霍尔传感器相比,灵敏度几乎提高了十倍,即恒压和恒流灵敏度分别为1200 V/V*T和130 V/V*T, 200mV/ a *T和23 mV/ a *T。高灵敏度可能与门控结构固有的放大机制有关。我们对内置增益的物理原理及其对偏置条件的依赖进行了解释。
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引用次数: 1
A new possibility of thick film biosensors substrate properties measurement 厚膜生物传感器衬底特性测量的新可能性
Pub Date : 2003-10-22 DOI: 10.1109/ICSENS.2003.1279019
J. Prásek, J. Krejčí
The aim of our work is to find effective way for study of TFT biosensors electrode substrates properties during biosensors fabrication, which is crucial question for the next development of this perspective technology. A new electrochemical analytical device was developed to ensure a defined mass transport to the electrodes, which is the most limiting process that influences the response quality of the sensor. The device consists of rotating conic vessel for measured sample and the thick film amperometric sensor trenching in. This new electrochemical analytical solution was registered for patenting. The biosensors' substrate responses were tested on basic electrochemical couple of potassium ferrocyanide-ferricyanide. Thick film biosensor's substrate response dependence on the liquid velocity and geometrical arrangement is presented.
我们的工作旨在为生物传感器制造过程中研究TFT生物传感器电极衬底特性找到有效的方法,这是该前景技术下一步发展的关键问题。一种新的电化学分析装置的开发,以确保一定的质量传递到电极,这是最限制的过程,影响传感器的响应质量。该装置由装有被测样品的旋转锥形容器和嵌入其中的厚膜安培传感器组成。该新型电化学分析溶液已申请专利。在氰化铁钾-铁氰化钾碱性电化学偶联上测试了生物传感器的底物响应。介绍了厚膜生物传感器的基底响应随液体速度和几何排列的变化规律。
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引用次数: 8
期刊
Proceedings of IEEE Sensors 2003 (IEEE Cat. No.03CH37498)
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