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Indexes Derived From Non-linear ESPVR ForEvaluation Of Ventricular Performance 非线性ESPVR预测心室功能的指标
Pub Date : 2013-04-24 DOI: 10.2495/BIO130121
R. Shoucri
Indexes derived from the non-linear end-systolic pressure-volume relation (ESPVR) are introduced in a way to study the performance of the left ventricle of the heart. The study sheds some light on the problem of heart failure with normal or preserved ejection fraction (HFpEF). It is shown that the ejection fraction (EF) is one index of several indexes that can be derived from the ESPVR in order to assess the performance of the left ventricle. Pressures acting on the left ventricle (ordinates of the ESPVR) as well as areas under the ESPVR (units of energy) can be used in assessing the performance of the left ventricle.
本文介绍了由非线性收缩末期压力-容积关系(ESPVR)导出的指标来研究心脏左心室的功能。该研究揭示了正常或保留射血分数(HFpEF)的心力衰竭问题。结果表明,射血分数(EF)是评价左心室功能的多项指标之一。作用于左心室的压力(ESPVR的坐标)以及ESPVR下的面积(能量单位)可用于评估左心室的性能。
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引用次数: 0
Experimental analysis of particles flow inside the Volumatic ® spacer volatic®隔离器内颗粒流动的实验分析
Pub Date : 2013-04-24 DOI: 10.2495/BIO130031
J. P. M. Costa, J. Teixeira, Luís F. Silva, S. Teixeira
At present there are several studies regarding the performance of many pressurized metered-dose inhalers (pMDIs), more precisely, spacers with special emphasis on the study and analysis of the fluids using (Computational Fluids Dynamics (CFD) software, in this specific case, Fluent™. The Volumatic ® is the most commonly used spacer nowadays, and, therefore, the one that has been studied more. However, and in spite of all the simulations carried out with air and drug particles, there is no confirmation with an actual experimental testing procedure regarding the drug dynamics inside a particular spacer. Therefore, and to validate the simulated studies carried out before in this area, a mechanical system able to duplicate the respiratory system was designed and implemented so that the same conditions inputted to the simulation tools could be tested and compared. In order to collect the data for this analysis, the Laser Doppler Anemometry (LDA) technique was used, which enables the measurement of the velocity of the particles through the center and some frontier regions of the studied spacer. As expected, it was possible to observe areas of recirculation, with a similar tendency to those obtained during simulation. The main difference relied on the absolute values of the velocity, which might be related to the lack of symmetry along the spacer and also probably due to the turbulent flow that probably exists inside the tube included in the mechanism used to simulate the respiratory system.
目前,有几项关于许多加压计量吸入器(pmdi)性能的研究,更准确地说,是使用计算流体动力学(CFD)软件对流体进行研究和分析的间隔器,在这种特殊情况下,使用Fluent™。Volumatic®是目前最常用的隔离剂,因此,研究较多。然而,尽管对空气和药物颗粒进行了所有的模拟,但对于特定间隔内的药物动力学,并没有通过实际的实验测试程序得到证实。因此,为了验证之前在该领域进行的模拟研究,我们设计并实现了一个能够复制呼吸系统的机械系统,以便可以对输入到模拟工具中的相同条件进行测试和比较。为了收集分析所需的数据,采用了激光多普勒测速(LDA)技术,该技术可以测量粒子通过所研究的间隔器中心和一些边界区域的速度。正如预期的那样,有可能观察到再循环区域,其趋势与模拟期间获得的趋势相似。主要的差异取决于速度的绝对值,这可能与沿间隔片缺乏对称性有关,也可能是由于用于模拟呼吸系统的机制中可能存在的管内湍流。
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引用次数: 0
Generation and applications of CT images of the ideal standing position for total knee arthroplasty surgery 全膝关节置换术中理想站立位CT图像的生成及应用
Pub Date : 2013-04-24 DOI: 10.2495/BIO130241
A. Doi, Hiroki Takahashi, T. Mawatari, S. Ichinohe
CT images with body weight loading are desired for preoperative planning on TKA surgery. In our proposed method, we perform stress analysis by the finite element method (FEM) for bone mesh structure by generating CT images, and we estimate an ideal standing position of the loaded state (referred to as deformed CT images of the ideal standing position). We also compare the deformed CT image with CR images, and evaluate the effectiveness in several ways.
术前计划TKA手术需要有体重负荷的CT图像。在我们提出的方法中,我们通过生成CT图像对骨网结构进行有限元法(FEM)应力分析,并估计出加载状态下的理想站立位置(称为理想站立位置的变形CT图像)。我们还比较了变形的CT图像和CR图像,并从几个方面评价了有效性。
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引用次数: 0
Effectiveness of a pesticide protective behavior program in improving and reducing neuromuscular symptoms among rice farmers in Sukhothai province, Thailand. 农药保护行为项目在改善和减少泰国素可泰省稻农神经肌肉症状中的有效性
Pub Date : 2013-04-23 DOI: 10.2495/EHR130051
Phataraphon Markmee, S. Taneepanichskul, R. Chapman
The problem of inappropriate pesticide usage is an important concern for occupational authorities in Thailand. There have been few intervention studies aimed at improving protective behavior and reducing health risk. In this quasiexperimental study, we conducted a pesticide protective behavior intervention program. We assessed the effectiveness of this intervention in improving protective behavior, and reducing neuromuscular symptom prevalence, among 182 rice farmers from December 2011 to June 2012 in Sukhothai province, Thailand. The intervention group comprising 91 rice farmers received a 1-month intervention program. Outcomes were measured before intervention (baseline), and at 1 and 4 months after intervention. The effects of intervention were evaluated with difference-of-difference analysis. The result revealed that all the participants had retention all follow-up time. At baseline, the mean protective behavior score was 50.7 in both the groups. The intervention program improved the protective behavior by a mean score of 8.6 (95%CI 7.4–9.9; p<0.001) one month after the intervention and by a mean score of 6.2 (95%CI 3.9–8.5; p<0.001) 4 months later, and reduced the prevalence of neuromuscular symptoms by 30.3 percent-points (95%CI −42.5 to −18.2; p<0.001) one month after the intervention and by 31.0 percent-points (95%CI −47.4 to −t4.7; p<0.001) 4 months after the intervention. Thus, this program should be considered for implementation to improve the safe use of pesticides in other
农药使用不当的问题是泰国职业当局关注的一个重要问题。很少有旨在改善保护行为和降低健康风险的干预研究。在这个准实验研究中,我们进行了一个农药保护行为干预项目。我们评估了2011年12月至2012年6月期间泰国素可泰省182名稻农在改善保护行为和减少神经肌肉症状患病率方面的干预效果。由91名稻农组成的干预组接受了为期1个月的干预计划。在干预前(基线)以及干预后1个月和4个月测量结果。采用差异分析评价干预效果。结果显示,所有参与者在随访期间都有记忆保留。在基线时,两组的平均保护行为评分均为50.7分。干预方案改善保护行为的平均得分为8.6 (95%CI 7.4-9.9;p<0.001),平均评分为6.2分(95%CI 3.9-8.5;p<0.001),并将神经肌肉症状的患病率降低了30.3% (95%CI为- 42.5 ~ - 18.2;p<0.001),干预后1个月和31.0% (95%CI - 47.4至- t4.7;P <0.001)。因此,应考虑实施该方案,以提高其他地区农药的安全使用
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引用次数: 2
Development of radiation monitoring services for radiation workers in Saudi Arabia. 为沙特阿拉伯的辐射工作人员发展辐射监测服务。
Pub Date : 2013-04-23 DOI: 10.2495/EHR130091
K. Al-Hadyan, S. Binjamaan, F. Mahyoub, G. Alsbeih, B. Moftah
The Biomedical Physics Department at King Faisal Specialist Hospital and Research Centre was established in 1980. This report evaluates the Health Physics Section services for all radiation workers in Saudi Arabia during the period between 2006 and 2012. In 2012, a total of 19,054 Thermoluminescent Dosimeter chips were issued compared to 2,480 TLD chips in 2006. The Secondary Standards Dosimetry Laboratory has calibrated 1,075 survey meters in 2012 compared to 356 in 2006. In 2012, the radiation biodosimetry laboratory has been established and constructed a dose calibration curve. This report shows the improvement of radiation monitoring services in Saudi Arabia.
费萨尔国王专科医院和研究中心的生物医学物理系成立于1980年。本报告评估了2006年至2012年期间卫生物理科为沙特阿拉伯所有辐射工作人员提供的服务。与2006年的2480个TLD芯片相比,2012年共发行了19054个热释光剂量计芯片。二级标准剂量测定实验室从2006年的356个测量仪表校准到2012年的1075个。2012年,辐射生物剂量学实验室建立并构建了剂量校准曲线。这份报告显示了沙特阿拉伯辐射监测服务的改善。
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引用次数: 1
A Walloon spatial simulation model of risks in environment and health 环境与健康风险的瓦隆空间模拟模型
Pub Date : 2013-04-23 DOI: 10.2495/EHR130041
N. Stéphenne, S. Remy, S. Eloy, F. Stassen, J. Defoux
To develop a spatial and quantitative analysis of health problems related to the environment is a challenging exercise combining different factors of risk and many actors. Using geographic information systems (GIS), multi-criteria decision theory and fuzzy logic, our risk simulation model aims to support decision makers to better understand, analyse and manage the health of the population in relation to environmental pollutions. This tool will be used within an exchange platform between the responsible authorities such as data providers and experts in health and environment to set up priorities in managing the complex system of health and environment at the level of the Walloon Region. This paper describes the purpose of this simulation model of risks, its technical development with a first set of simulation data and the proposed way of using this tool by authorities.
对与环境有关的健康问题进行空间和数量分析是一项具有挑战性的工作,它结合了不同的风险因素和许多行为者。利用地理信息系统(GIS)、多准则决策理论和模糊逻辑,我们的风险模拟模型旨在支持决策者更好地理解、分析和管理与环境污染有关的人口健康。该工具将在数据提供者和卫生与环境专家等主管当局之间的交流平台内使用,以确定在瓦隆地区一级管理复杂的卫生与环境系统的优先事项。本文描述了该风险模拟模型的目的、第一组模拟数据的技术发展以及当局使用该工具的建议方法。
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引用次数: 4
Cyperus longus L. as a biological purifier of wastewater for irrigation purposes: removal efficiency and Zn, Cd, Cu, Fe and Mn. 长草作为灌溉废水生物净化器:去除Zn、Cd、Cu、Fe和Mn的效率。
Pub Date : 2013-04-23 DOI: 10.2495/EHR130211
D. A. Ganjo, H. Mirza
The common and cosmopolitan distributed wastewater macrophyte, namely, Cyperus longus L. was tested as a biological wastewater purifier. Indoor experiments were mainly based on conventional wastewater treatment processes, besides the specified design of sand filtration pots, implanted by C. longus L. Untreated and treated wastewater samples were analyzed for their key physicochemical properties and some heavy metals (only the removal efficiency of the heavy metals Zn, Cd, Cu, Fe and Mn by C. longus L. is highlighted in this paper). After 129 days (including 45 days, the time needed for the growth/stabilization of C. longus L. in experiment pots) the C. longus L. was harvested and heavy metals were analyzed in root and shoot systems. The removal efficiency (i.e. uptake/bioaccumulation rate) was then followed up. Results showed that the accumulation rate in the plant roots was much higher than the shoots. Higher metal bioaccumulation per cent was noted in roots; Zn (0.522%), Cu (0.821%), Fe (80.480%), Mn (1.886%) and Cd (0.659%) compared with control (irrigated with clean water); Zn (0.147%), Cu (0.167%), Fe (12.590%), Mn (0.331%) and Cd (0.124%). On the other hand, metal bioaccumulation per cent in shoot system was: Zn (0.412%), Cu (0.458%), Fe (4.540%), Mn (1.719%) and Cd (0.567%) compared with control. Always, the more replicated sand filtration pots the highest removal efficiency of heavy metals was achieved.
对普遍分布的污水大型植物——长草(Cyperus longus L.)作为污水生物净化器进行了试验。室内实验主要以常规废水处理工艺为基础,在指定设计砂滤池的基础上,对未经处理和处理的废水样品进行了主要理化性质和部分重金属的分析(本文仅重点介绍了长叶藻对重金属Zn、Cd、Cu、Fe和Mn的去除效果)。129 d后(其中45 d为试验田长柳枝生长/稳定所需时间),采收长柳枝,分析根、梢系统重金属含量。然后跟踪去除效率(即吸收/生物积累速率)。结果表明,植物根系的积累速率远高于茎部。根中金属生物积累率较高;Zn(0.522%)、Cu(0.821%)、Fe(80.480%)、Mn(1.886%)、Cd(0.659%)高于对照(清水灌溉);锌(0.147%)、铜(0.167%)、铁(12.590%)、锰(0.331%)和Cd(0.124%)。另一方面,与对照相比,金属在茎部系统中的生物累积率分别为:Zn(0.412%)、Cu(0.458%)、Fe(4.540%)、Mn(1.719%)和Cd(0.567%)。砂滤池的重复次数越多,对重金属的去除效果越好。
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引用次数: 2
Place based education in the context of waste-related implications on health and welfare among Bedouin Arab communities in the Israeli Negev. 在废物对以色列内盖夫贝都因阿拉伯社区健康和福利影响的背景下开展基于地方的教育。
Pub Date : 2013-04-23 DOI: 10.2495/EHR130171
O. B. Assaraf, J. Cwike, W. Sedawi, G. Tsofit
Waste and its proper management is a central environmental issue that is currently confronting countries around the world. Uncontrolled waste production and disposal can cause long-term environmental damage to air, water, land, and to the health of humans – most particularly children. Every year, approximately 5.2 million people, including 4 million children, die of waste-related diseases. In Israel, solid urban waste is disposed of primarily in landfills (85%), but the unrecognized Bedouin settlements in the Negev desert do not have access to regular waste disposal. This forces their residents to try and manage their waste themselves by incineration and other unofficial methods such as dumping and use of refuse pits, practices that are proving hazardous to the community’s environment and to its health. Our study is part of an extensive project designed to encourage the use of alternative means of waste disposal and technologies for recycling and generating bio-gas and to provide Bedouin women with the knowledge of this technology along with its health benefits. While an earlier study was focused on the adult patterns and perceptions in dealing with environmental waste, this one focuses on those of the community’s children, who are active participants in the disposal of domestic waste, and who are therefore also exposed to its hazards. The goal of this study is to develop an elementary school curriculum to provide students with the knowledge and cognitive skills to cope with environmental hazards that they are exposed to in their local environment with an emphasis on waste.
废物及其适当管理是世界各国目前面临的一个中心环境问题。不加控制的废物生产和处置会对空气、水、土地和人类健康造成长期的环境损害,尤其是对儿童。每年约有520万人,包括400万儿童,死于与废物有关的疾病。在以色列,城市固体废物主要在垃圾填埋场处理(85%),但内盖夫沙漠中未得到承认的贝都因人定居点无法获得常规废物处理。这迫使他们的居民试图通过焚烧和其他非官方的方法,如倾倒和使用垃圾场,自己管理废物,这些做法已被证明对社区环境和健康有害。我们的研究是一个广泛项目的一部分,该项目旨在鼓励使用废物处理的替代手段和回收和产生生物气体的技术,并向贝都因妇女提供这项技术的知识及其对健康的好处。先前的一项研究侧重于成人处理环境废物的方式和观念,而这项研究侧重于社区儿童的方式和观念,他们积极参与处理家庭废物,因此也受到其危害的影响。本研究的目的是发展一套小学课程,以提供学生知识和认知技能,以应对他们在当地环境中暴露的环境危害,重点是废物。
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引用次数: 0
Micronucleus frequencies in lymphocytes and buccal cells in formaldehyde exposed workers 甲醛暴露工人淋巴细胞和颊细胞微核频率
Pub Date : 2013-04-23 DOI: 10.2495/EHR130081
S. Costa, Fátima Brandão, M. Coelho, C. Costa, P. Coelho, S. Silva, B. Porto, J. Teixeira
Formaldehyde (FA) is a high-volume production chemical produced worldwide with a large range of industrial and medical uses. Listed, since 2004, by IARC as a human carcinogen, FA status was recently revised by the US government who reclassified this compound as known to be a human carcinogen. Both reclassifications are based on sufficient evidence of carcinogenicity from epidemiologic studies, supporting data on mechanisms of carcinogenesis and experimental evidence in animals. The highest level of human exposure to FA occurs in occupational settings. Consistent findings of increased risks of certain types of rare cancers were found among workers with higher measures of exposure to FA (exposure level or duration). The aim of the present study was to assess the genotoxic effects of occupational exposure to FA. A group of pathology and anatomy workers was evaluated for micronuclei in lymphocytes and in exfoliated buccal cells. Genotoxic endpoints are of great interest in the risk assessment of occupational carcinogens because they precede by a long time the potential health effects, thus offering a greater potential for preventive measures. Micronuclei in lymphocytes and in exfoliated buccal cells were significantly higher in the exposed subjects when compared with controls. Air sampling was performed in the workers’ breathing zone for representative working periods and an 8h-time weighted average was assessed. Results
甲醛(FA)是一种在世界范围内大量生产的化学品,具有广泛的工业和医疗用途。自2004年以来,国际癌症研究机构将其列为人类致癌物,最近美国政府修订了FA的地位,将这种化合物重新归类为已知的人类致癌物。这两种重新分类都是基于流行病学研究中关于致癌性的充分证据、支持致癌性机制的数据和动物实验证据。人类接触FA的最高水平发生在职业环境中。在暴露于FA(暴露水平或持续时间)较高的工人中发现了某些类型罕见癌症风险增加的一致发现。本研究的目的是评估职业暴露于FA的遗传毒性效应。一组病理和解剖工作者在淋巴细胞和脱落的颊细胞中进行了微核评估。基因毒性终点在职业致癌物的风险评估中非常重要,因为它们比潜在的健康影响早很长时间,因此提供了更大的预防措施的潜力。与对照组相比,接触者的淋巴细胞和脱落的颊细胞中的微核明显更高。在有代表性的工作期间,在工人的呼吸区进行空气采样,并评估8小时加权平均值。结果
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引用次数: 1
Musculoskeletal disorders caused by physical overload: the situation in Latvia 身体负荷过重引起的肌肉骨骼疾病:拉脱维亚的情况
Pub Date : 2013-04-23 DOI: 10.2495/EHR130071
J. Reste, M. Eglīte, A. Rubine, J. Cīrule, G. Zubkova, T. Zvagule, I. Vanadziņš
For Latvian society musculoskeletal disorders (MSDs) are becoming an urgent problem like in the majority of European countries. Physical overload is one of the most important aetiological factors for development of work-related MSDs. The aim of the study was analysis of occupational MSDs’ incidence tendencies in Latvia during the time period from 1996 till 2011. Data of Latvian State Register of Occupational Diseases about incidence of occupational MSDs according to Latvian official list of occupational disorders were used. The time period between 1996 and 2011 was analysed in detail. This current paper reports a rapid increase in number of occupational MSDs revealed for the first time every year in Latvia. At the same time, a gradual decrease of “classical” occupational diseases, such as respiratory disorders caused by dust and chemical substances was observed during the period of analysis. In most cases, more than one MSD was diagnosed for one patient. The largest part of these MSDs was chronic, disabling and had been acquired for a long time before being revealed. In 94.8% of all patients with firstly revealed occupational diseases in 2011 factor physical overload (i.e. heavy lifting, repetitive or highly differentiated movements or awkward working posture, manual handling) were mentioned as harmful working risk factors. During the last ten years MSDs have taken first place in the occupational morbidity structure of Latvia. Considering the present situation in Latvia, special attention of OH&S specialists should be paid to the early prevention of MSDs and fight against physical overload at work places.
与大多数欧洲国家一样,拉脱维亚社会的肌肉骨骼疾病(MSDs)正在成为一个紧迫的问题。身体负荷过重是诱发职业病的重要原因之一。本研究的目的是分析1996年至2011年期间拉脱维亚职业性MSDs的发病率趋势。根据拉脱维亚官方职业病清单,使用了拉脱维亚国家职业病登记处关于职业性MSDs发病率的数据。详细分析了1996年至2011年这段时间。本文报告了拉脱维亚每年首次披露的职业MSDs数量的快速增长。与此同时,在分析期间,观察到由粉尘和化学物质引起的呼吸系统疾病等"经典"职业病逐渐减少。在大多数情况下,一个病人被诊断出不止一个MSD。这些msd的大部分是慢性的,致残的,在被发现之前已经获得了很长时间。在2011年首次发现职业病的所有患者中,94.8%的人将体力超负荷(即举重、重复或高度分化的动作或尴尬的工作姿势、手工搬运)列为有害的工作危险因素。在过去十年中,MSDs在拉脱维亚的职业发病率结构中占据首位。考虑到拉脱维亚目前的情况,职业健康和安全专家应特别注意早期预防MSDs,并与工作场所的物理超载作斗争。
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引用次数: 2
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WIT Transactions on Biomedicine and Health
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