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Impact of Modern Analytical Tools In The Standardization of Kharaliya Rasayana (Arogyavardhini Rasa) 现代分析工具对< < < < < < < < < < < < < < < < < < < > > > > >规范化的影响
Pub Date : 2021-11-06 DOI: 10.51648/jac.29
Dr.Yuga Raj Sapkota, B. Patgiri, Dr. V. J. Shukla, P. Prajapati
Background: Arogyavardhini Rasa is a well known Ayurvedic herbo-mineral formulation widely used for a broad spectrum of therapeutic indications mainly in the treatment of Kamala (jaundice) and other Yakrit Vikara (liver disorders). Aim: To standardized Arogyavardhini Rasa prepared with and without Rasavarga Dravya (ingredients of Metallo-mineral origin) by using high-performance thin-layer chromatography (HPTLC)  & computational by principal component analysis (PCA)  as an analytical tool.    Materials & Method: Arogyavardhani Rasa (AVR) was prepared as per classical reference and further modified this preparation by omitting  Rasavarga dravya (ingredients of Metallo-mineral origin) of Arogyavardhani Rasa (MAVR). Formulations were investigated for physicho-chemical parameters, chromatography and using the building block of chemometrics technique such as PCA was applied to discriminate the formulations AVR and MAVR. Result & Discussion: HPTLC study revealed a total of 11 and 8 bands at 254 nm and 366 nm in both AVR & MAVR, with only two similar Rf values in the sample. PCA revealed that both formulations were found similarities & dissimilarities within a batch of AVR and MAVR with its physicho-chemical constant. Conclusion: The analytical tools applied (HPTLC and PCA)  for the study revealed that the classical processing like Bhavana (Lavigation ), Mardana (Trituration) etc. had a significant role in the preparation of Rasaaushadhis (mercurial medicine) and process validate the Indian system of medicinal pharmaceutics.
背景:Arogyavardhini Rasa是一种著名的阿育吠陀草药矿物配方,广泛用于治疗各种适应症,主要用于治疗黄疸和其他肝脏疾病。目的:采用高效薄层色谱法(HPTLC)和主成分计算分析法(PCA)对加和不加金属矿源成分沙乌沙制备的沙乌沙进行标准化。材料与方法:根据经典参考文献制备Arogyavardhani Rasa (AVR),并通过省略Arogyavardhani Rasa (MAVR)中的Rasavarga dravya(金属矿物来源的成分)对该制剂进行进一步修改。对配方进行了理化参数、色谱分析,并利用主成分分析法等化学计量学技术对AVR和MAVR进行了鉴别。结果与讨论:HPTLC研究显示AVR和MAVR在254 nm和366 nm处共有11个和8个波段,样品中只有两个相似的Rf值。主成分分析表明,两种配方在AVR和MAVR的理化常数上存在相似性和差异性。结论:采用HPTLC和PCA等分析工具,揭示了Bhavana (navigation)、Mardana (tritururation)等经典工艺在汞药Rasaaushadhis (mercurial medicine)的制备过程中具有重要作用,工艺验证了印度医药体系。
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引用次数: 0
KANCHNAR TWAK, SHUNTHI CHURNA AND NIMB TAIL NASYA IN HYPOTHYROIDISM- A REVIEW
Pub Date : 2021-11-06 DOI: 10.51648/jac.23
Ajay Kumar Ajay Gupta, Pratima Yadav
Today’s era hypothyroidism is one of the most common and challenging disease in our society. Thyroid is the second most prevailing disorder in daily OPD. In endocrine system thyroid gland does not produce enough thyroid hormone so it’s called Hypothyroidism. Levothyroxine is the most efficacious hormone replacement treatment and this thyroxin therapy starting from 25mcg/day for hypothyroidism. The female-male ratio is approximately 6:1. Ayurveda has not mentioned endocrine disorders, instead for treatment of unspecified syndromes, it emphasizes on careful observation of symptoms and pathophysiology. In Ayurveda it can be co-related with the actions of “AGNI”.  The sign and symptoms of hypothyroidism are similar to those of Kapha vriddhi (increases in kapha), Rasa Dushti, Medas dushti, Medas dhatwagni mandya(slow metabolism at adipose tissue level), and Kapha Avaran janya Dhatwagni Mandya (slow metabolism due to blockage of kapha). In ayurvedic text there is no direct reference of hypothyroidism but Galganda and Gandamala frequently used in the text. According to Charaka a swelling that is caused when a vitiated kapha affects the throat from the outside, and gradually produces swelling, is called galagand. Galgand is explained classically in all the Ayurvedic texts, including Shushruta and Astang hruday, since Galgand is the most untouched topic in Ayurveda and since Hypothyroidism is becoming one of the common problems in day-to-day practice. By using modern medicine many side effects occurs but through ayurwedic drugs hypothyroidism can be managed easily. This article discusses efficacy of Kanchnar twak kwath with shunthi churna and nimb tail Nasya in Hypothyroidism.
当今时代甲状腺功能减退症是我们社会中最常见和最具挑战性的疾病之一。甲状腺是日常门诊第二大常见疾病。在内分泌系统中,甲状腺不能产生足够的甲状腺激素,所以被称为甲状腺功能减退症。左旋甲状腺素是最有效的激素替代治疗,这种甲状腺素治疗从每天25mcg开始治疗甲状腺功能减退。男女比例约为6:1。阿育吠陀没有提到内分泌失调,而是对未指明证候的治疗,强调仔细观察症状和病理生理。在阿育吠陀,它可以与“AGNI”的行动相关。甲状腺功能减退症的体征和症状与Kapha vriddhi (Kapha增加)、Rasa Dushti、Medas Dushti、Medas dhatwagni mandya(脂肪组织水平代谢缓慢)和Kapha Avaran janya dhatwagni mandya(Kapha堵塞导致代谢缓慢)相似。在阿育吠陀文本中没有直接提及甲状腺功能减退症,但伽尔甘达和甘达马拉经常在文本中使用。根据《查拉卡》的说法,当一种变质的卡法从外部影响喉咙并逐渐产生肿胀时,就会引起肿胀,这被称为肿胀。在所有的阿育吠陀文献中都有经典的解释,包括《舒什鲁塔》(Shushruta)和《阿斯坦节》(Astang hrudday),因为伽尔甘是阿育吠陀中最未被触及的话题,而且甲状腺功能减退症正在成为日常实践中的常见问题之一。通过使用现代医学,许多副作用发生,但通过印度草药药物甲状腺功能减退症可以很容易地管理。本文探讨了加用顺提肾、腰尾喉治疗甲状腺功能减退症的疗效。
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引用次数: 0
LITERARY REVIEW ON AGEING PROCESS AND IT'S NATURAL AYURVEDA APPROACH 关于衰老过程的文献综述和自然的阿育吠陀方法
Pub Date : 2021-11-06 DOI: 10.51648/jac.41
Dr. Mithilesh Kumar Sah, B. Singh, P. Singh
In Ayurveda, Ageing is termed as ‘Jara’ for which some rules are given to make it healthy with longevity. This is the phase anticipatory care should be taken so that ageing process can be deferred and old age related diseases can be barred. Jara as natural prodigy of human body takes place in two ways i.e. Kalaja and Akalaja. Body gets affected from various factors like diet pattern, food particles, lifestyle, environment, etc. changes or degenerative changes are the nature of universe. These changes are known as Swabhaav in Ayurveda in which a constant decline may found in Shareera in old age. Ageing starts in different attributes at different period; thus, the ancient classics give a detailed version on the physiological, psychological and biological aspects of ageing including growth, puberty and senility.There are enough matter in relation to the establishment and termination of life which can be understood as theory as Theory of Innate Destruction (Swabhawoparamavada), Theory of Disturbance in Fundamental Principle of Body, Theory related to Kala (Time Factor), Theory Related to Environmental and other Biological Aspect. Jara management can be done via programming of lifestyle in such a way that Akalaj Jara can be avoided and Kalaj Jara can be delayed. For this purpose not only the Rasayana drugs but Ayurvediya Dinacharya, Ritucharya and other regimens in the way of ideal lifestyle is to be followed.
在阿育吠陀中,衰老被称为“哈拉”,为此制定了一些规则,使其健康长寿。在这一阶段,应当采取预先护理,以便延缓老龄化进程,防止与老年有关的疾病。哈拉作为人体的自然奇迹,以两种方式发生,即卡拉贾和阿卡拉贾。人体受到各种因素的影响,如饮食模式、食物颗粒、生活方式、环境等,变化或退化变化是宇宙的本质。这些变化在阿育吠陀中被称为Swabhaav,在老年时,沙雷拉可能会出现持续的衰退。不同属性的老龄化在不同时期开始;因此,古代经典对衰老的生理、心理和生物方面给出了详细的描述,包括生长、青春期和衰老。关于生命的建立和终结,有足够的理论可以理解为先天破坏理论(Swabhawoparamavada),身体基本原理的干扰理论,与Kala(时间因素)有关的理论,与环境和其他生物方面有关的理论。我们可以通过规划生活方式来控制痢疾,这样就可以避免痢疾,也可以推迟痢疾。为了达到这个目的,不仅要遵循罗萨亚那的药物,还要遵循阿育吠陀法、利图查利亚法和其他理想生活方式的养生法。
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引用次数: 0
Ayurveda and post-acute sequelae of SARS-CoV-2 infection (PASC) Management 阿育吠陀与SARS-CoV-2感染急性后后遗症(PASC)的管理
Pub Date : 2021-11-06 DOI: 10.51648/jac.57
Journal of Ayurveda Campus
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first detected in China in December 2019. Coronavirus disease 2019 (COVID‐19) has been one of the major pandemics affecting all the world and human beings. Since then, more than 241 million people worldwide have been infected, and over 4 million people have died from the COVID-19. In Nepal, it is 807 thousand people have been infected, and more than 11 thousand people have been died from the disease till date.1
2019年12月,中国首次发现了严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)。2019冠状病毒病(COVID - 19)已成为影响全球和人类的重大流行病之一。自那时以来,全球已有超过2.41亿人感染,400多万人死于COVID-19。在尼泊尔,已有80.7万人被感染,迄今已有1.1万人死于该病
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引用次数: 4
TRADITIONAL KNOWLEDGE AS A PROTECTED FORM OF INTELLECTUAL PROPERTY RIGHTS IN NEPAL: A LAW AND POLICY ASSESSMENT 尼泊尔作为知识产权保护形式的传统知识:一项法律和政策评估
Pub Date : 2021-11-06 DOI: 10.51648/jac.40
Viajay Prasad Jayswal
A serious discourse is built around the world for proper and better protection of traditional knowledge associated with intellectual property rights. Traditional knowledge was considered as a leftover subject in intellectual property governance since the IP has been a talk of the town. Nepal is rich in terms of traditional knowledge associated with indigenous communities largely used in the medical sectors or what we generally name with “ home-grown medicines”. There is a lack of proper protection and also incentives for these communities and researches have shown that there are also possibilities of conflict over ownership over such knowledge. The traditional knowledge will not only benefit particular stakeholders rather in an extended way, it creates values for the nation and ultimately a global asset in the intellectual property regime across the world. The IP Policy, Law, and Regulations need further incorporation of elements as the subject of traditional knowledge specifically used for medicinal purposes. This paper is based on a theoretical analysis of law, policies, rules, cases, and practices for the protection of traditional knowledge for medicinal in Nepal. This paper has further analyzed the position of existing umbrella clauses as seen in intellectual property laws for the said purpose.
世界各地正在建立一种严肃的论述,要求适当和更好地保护与知识产权有关的传统知识。传统知识在知识产权治理中被认为是一个剩余的主体,因为知识产权已经成为一个话题。尼泊尔拥有丰富的与土著社区有关的传统知识,这些知识主要用于医疗部门,或者我们通常称之为"本土药物"。这些社区缺乏适当的保护和激励措施,研究表明,对这些知识的所有权也有可能发生冲突。传统知识不仅会以一种广泛的方式使特定的利益相关者受益,它还会为国家创造价值,并最终成为世界各地知识产权制度中的全球资产。知识产权政策、法律和条例需要进一步纳入专门用于医疗目的的传统知识的主题。本文基于对尼泊尔传统医药知识保护的法律、政策、规则、案例和实践的理论分析。本文进一步分析了知识产权法中现有保护伞条款的地位。
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引用次数: 0
Management of Polycystic ovarian syndrome (PCOS) with Ayurveda - a case study 阿育吠陀治疗多囊卵巢综合征(PCOS)的案例研究
Pub Date : 2021-11-06 DOI: 10.51648/jac.35
Dr. Kajal Jha, Amulya Dahal, Bijendra Shah, P. Tripathi, Sabbu Thasineku
Polycystic Ovarian Syndrome (PCOS) is one of the most common problems affecting approximately5% of all women.  PCOS can affect menstrual cycle, fertility, and hormone level as well as appearance including acne, facial hair growth and balding, overweight. Some women may suffer from depression. It is also a metabolic problem that affects several body systems. The condition gets its name because there are often an increased number of small painless cysts in the ovaries (polycystic ovaries). It is very difficult to cure in contemporary system and treatment is also very costly. A case of 19 years female suffering from PCOS reported was treated successfully at at Ayurveda Teaching Hospital within 1 month by various ayurveda medicine and panchakarma procedures. The improvement is evident from regularity of menstrual cycle and also from the ultrasonography (USG) reports.
多囊卵巢综合征(PCOS)是影响约5%女性的最常见问题之一。多囊卵巢综合征会影响月经周期、生育能力、激素水平以及外观,包括痤疮、面部毛发生长、秃顶、超重。有些女性可能患有抑郁症。它也是一种代谢问题,影响几个身体系统。这种情况之所以得名,是因为卵巢中经常有越来越多的小的无痛囊肿(多囊卵巢)。在现有的治疗体系中,该病很难治愈,而且治疗费用也非常昂贵。报告一例19岁女性多囊卵巢综合征在阿育吠陀教学医院1个月内通过各种阿育吠陀药物和panchakarma程序成功治疗。从月经周期的规律性和超声(USG)报告中可以明显看出这种改善。
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引用次数: 2
Management of Grahani roga in Ayurveda (irritable bowel syndrome)- A case report 阿育吠陀Grahani roga(肠易激综合征)的治疗- 1例报告
Pub Date : 2021-11-06 DOI: 10.51648/jac.38
Amulya Dahal, Dr. Mahesh Prasad Shah, Dr. Prashant Kumar Singh
Grahani Roga is a common Gastro-intestinal Tract disorder of present era. In Ayurveda, Grahani is considered as the main functional part of Mahasrota which is located in between amashaya & pakwashaya, also known as the 6th kala i.e., Pittadhara Kala where jatharagni resides and its main function is to hold the ahara upto the end of avasthapaka & after completion passes it into pakvasaya. Symptoms like alternate passing of hard & loose stool, abdominal pain, passing of foul-smelling stool, mucus in faecal matter are diagnostic of Grahani Roga. In modern science, above mentioned symptoms can be correlated with IBS (Irritable Bowel Syndrome). In IBS, the wall of the intestine becomes sensitive to even mild stimulus which causes excess abdominal cramps & hence the bowel movement alters along with indigestion. In this case an effort has been made to treat 33 years male suffering from Grahani roga, at Ayurveda Teaching Hospital within 3 months by various ayurveda medicine and panchakarma procedures.
Grahani Roga是当代常见的胃肠道疾病。在阿育吠陀中,Grahani被认为是Mahasrota的主要功能部分,位于amashaya和pakwashaya之间,也被称为第六卡拉,即jatharagni所在的Pittadhara卡拉,其主要功能是将ahara保持到avasasapaka的末端,完成后将其传递到pakvasaya。如硬便和稀便交替排出、腹痛、恶臭粪便排出、粪便中有粘液等症状是格拉哈尼罗加的诊断。在现代科学中,上述症状可能与肠易激综合征(IBS)有关。在肠易激综合征中,肠壁对即使是轻微的刺激也会变得敏感,这会导致腹部过度痉挛,因此排便会随着消化不良而改变。在这种情况下,在阿育吠陀教学医院,通过各种阿育吠陀药物和全身疗法,努力在3个月内治疗患有格拉哈尼罗加病的33岁男性。
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引用次数: 0
LITERARY REVIEW ON CHURNA - AYURVEDA DOSAGE FORM 朱娜-阿育吠陀剂型的文献综述
Pub Date : 2021-11-06 DOI: 10.51648/jac.31
Dr. Prashant Kumar Singh, Mithilesh Kumar Shah, B. Singh
Bhaishajya Kalpana describes various types of dosage forms mainly prepared from herbal ingredients. The term Churna may be applied to the powder prepared by a single drug or a combination of more drugs. It may be considered as modified form of Kalka Kapana. For attaining better therapeutic results, it is advisable to powder all the drugs of formulation separately and then only they are supposed to be mixed together uniformly. It can be used as main medicament in the treatment of many diseases. It has both advantages and disadvantages. It can be used as Prakshepaka Dravya along with quantity & Sevana Vidhi. Hence, the prepared drug is to be stored in Air tight containers  for packaging with maintaining quality parameters.
Bhaishajya Kalpana描述了主要由草药成分制备的各种类型的剂型。术语Churna可用于由单一药物或多种药物的组合制备的粉末。它可以被认为是卡尔卡·卡帕那的改良形式。为了获得更好的治疗效果,建议将配方中所有药物分别粉末,然后均匀混合在一起。它可以作为治疗许多疾病的主要药物。它既有优点也有缺点。它可以作为Prakshepaka Dravya与quantity和Sevana Vidhi一起使用。因此,制备的药物应储存在气密容器中进行包装,以保持质量参数。
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引用次数: 0
A retrospective study of overview of patients visited at Kayachikitsa department’s OPD at TUACTH 在TUACTH Kayachikitsa部门OPD访问的患者概况的回顾性研究
Pub Date : 2021-11-06 DOI: 10.51648/jac.30
Pramod Bhatta, S. Shrestha
Background: Kayachikitsa is one of the most important specialized departments in an Ayurvedic hospital. A number of patients get effective, affordable and safe Ayurvedic services from Out Patient Department (OPD). Objective: the major objective of this study was to find out the treated disease pattern, frequency of patients who got benefits from treatments and services provided in the OPD of Kayachikitsa department. Methods: The study was analytical retrospective in nature where analysis of registered patients’ case record of Kaya Chikitsa OPD during the period of May 15 to November 15 of year 2018 AD. Results: Despite of good number of patients visiting in the OPD of Kayachikitsa department, patients of  different  diseases visited and treated with Ayurvedic medications, due to lack of good publicity and awareness in general population about wide range of treatments available for various diseases in Kayachikitsa department. The follow up cases were also good. Conclusions: The study showed the Kayachikitsa department provided services to various diseases, health services to senior citizens. The follow up cases were also better suggestive of good quality services. Hence improving the services and conducting awareness program can provide better Ayurvedic health services to many needy people.
背景:Kayachikitsa是阿育吠陀医院最重要的专科之一。许多患者从门诊(OPD)获得有效、负担得起和安全的阿育吠陀服务。目的:本研究的主要目的是了解Kayachikitsa科门诊治疗和服务受益的患者的疾病类型和频率。方法:本研究为分析回顾性研究,分析了2018年5月15日至11月15日期间Kaya Chikitsa OPD的注册患者病例记录。结果:尽管到Kayachikitsa科门诊就诊的患者数量较多,但由于公众对Kayachikitsa科各种疾病的广泛治疗方法缺乏良好的宣传和认识,不同疾病的患者就诊并接受了阿育吠陀药物治疗。随访病例也很好。结论:研究表明,Kayachikitsa部门为老年人提供各种疾病和保健服务。随访病例也较好地反映了服务质量。因此,改善服务和开展宣传计划可以为许多有需要的人提供更好的阿育吠陀保健服务。
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引用次数: 0
Prevalence of diarrheageanic E. coli isolated from diarrheal stool from Children under 5 years of age at Kanti Children’s Hospital 从康提儿童医院5岁以下儿童的腹泻粪便中分离出致泻性大肠杆菌的流行情况
Pub Date : 2021-11-06 DOI: 10.51648/jac.28
Dr. Kirtika Gautam
Background: Diarrhea caused by diarrheagenic E.coli are major health problem of developing countries including Nepal.Though precise data on childhood diarrhea by diarrheagenic E.coli in Nepal is not available. It has been estimated that approximately 25% of  child death are associated with diarrhea.This study was thus carried out to evaluate the  incidence of diarrhea by diarrheagenic E.coli in children under 5 years of age. The study was conducted at  Kanti Children’s hospital (KCH), Maharajgunj.  A total of 200 samples were enrolled between March 2018 to August 2018. Methods: All the diarrheal stool samples were cultured on Mac Conkey agar plate. After 24 hours of incubation at 37  degree celcius. If it produce Lactose Fermenting (LF) pink coloured colonies  further confirmatory test was done by different biochemical test. Whether it was E. coli or not.If it was E.coli then further sub cultured on Mac Conkey Sorbitol (MSA) agar to isolate diarrheagenic E. coli. Next day if there seen Non Sorbitol Formenting (NSF) colonies, it was identified as diarrheagenic E. Coli. because most other E.coli strains and other Enterobacteria ferment sorbitol but diarrheagenic E.coli do not ferment Sorbitol and is non sorbitol fermenting colourless colonies. Results: Out of total enrolled cases, 20 (10%) were diarrheagenic E. coli. Gentamycin, Chloramphenicol and third generation Cephalosporin showed 100% efficacy against diarrheagenic  E.coli . Conclusion: The incidence of disease  was more prevalent in children below 2 years. Diarrheagenic E. coli were found to be a significant cause of diarrhea under 5 years of age. Awareness of improving hygiene reduce the episode of diarrhea.
背景:致泻性大肠杆菌引起的腹泻是包括尼泊尔在内的发展中国家的主要卫生问题。尽管在尼泊尔尚无致泻性大肠杆菌引起的儿童腹泻的精确数据。据估计,大约25%的儿童死亡与腹泻有关。因此,本研究旨在评估5岁以下儿童由致泻性大肠杆菌引起腹泻的发生率。这项研究在Maharajgunj的Kanti儿童医院(KCH)进行。在2018年3月至2018年8月期间,共招募了200个样本。方法:采用Mac Conkey琼脂平板培养所有腹泻粪便标本。在37摄氏度下孵育24小时后。如果产生乳糖发酵(LF)粉红色菌落,则通过不同的生化试验进行进一步的验证试验。不管是不是大肠杆菌。如果是大肠杆菌,则进一步在Mac Conkey山梨醇(MSA)琼脂上传代培养,分离致泻性大肠杆菌。第二天如果发现非山梨醇形成(NSF)菌落,则确定为致泻性大肠杆菌。因为大多数其他大肠杆菌菌株和其他肠杆菌都能发酵山梨醇,但致泻性大肠杆菌不发酵山梨醇,而且是非山梨醇发酵的无色菌落。结果:在所有入组病例中,20例(10%)为致泻性大肠杆菌。庆大霉素、氯霉素和第三代头孢菌素对致泻性大肠杆菌的疗效为100%。结论:本病以2岁以下儿童多见。致泻性大肠杆菌被发现是5岁以下儿童腹泻的重要原因。提高卫生意识可减少腹泻的发生。
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引用次数: 0
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