Subnational governments have become increasingly relevant actors in North America. This article examines international relations between subnational governments and dynamics of governance in the region; specifically, the relations of Canadian provinces with their counterparts in the United States and Mexico. It suggests that factors such as economic globalization, federalism, and decentralization have triggered increased paradiplomatic activities by subnational units. It also shows that international relations between Canadian provinces and subnational units in the United States are more significant than those with Mexico and involve mainly issues of sustainable economic development, the environment, natural resources, security, culture, education, science, and technology. These regional subnational dynamics have been crucial to finding solutions to common global and regional problems through subnational avenues and to advancing new forms of multilateral cooperation.